@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0845: (2016-03-19 )
MNQVAPFYADHVGSILRTKGIKDAREKFQSGEITALELRKIENTEIKYIVEKQKEVGLKSITDGEFRRAWWHFDFLENLDGVEGYDAAGGIQFSKVQTKSHSVKITGPIDFTTHPFIEDFIFLKEAVGDNHVAKQTIPSPAMLHYRGDIEYQPYLDDAEKFANDLATAYQKAIQAFYDAGCRYLQLDDTSWSYLCSDEQREVVRQRGFDPETLQETYKNLINEAIKHKPADMVITMHICRGNFRSTWIAEGGYGPVAETLFGKLNIDGFFLEYDNERSGDFAPLKYVTRPDLKIVLGLITSKTGELEDEAAIKARIEEASEIVPLSQLRLSPQCGFASTEEGNILTEEEQWDKLRYVVRLANDIWGE
Atome Classification :
(20 SA)
.........10.......---.---20....-....30........40........50........60........70........80....-----.----------------------.-------------..90........100.--.....-.110-........120.......130.......140-.......-----150---..----.----..----..---..160.......170.......180.......190.......200.......210.......220.......230---..--.-...-...240...---...-----.250.......260....-.....270.......280....--.-.----.-290.......300.......310.......320..-.....330.......340.----...------...350.......360.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNQVA
P
F
Y
A
D
H
V
G
S
I
L
R
T---K---G
I
K
D
A
R
-
E
KFQSG
E
I
T
A
L
E
L
R
KIENT
E
I
K
Y
I
V
E
K
Q
K
EVGLKSITDG
E
F
R
R
A
WWH
F
D
F
L
ENLDGVEGY-----D----------------------A-------------AG
G
I
Q
F
S
K
V
QTKS
H
S
V
--
K
I
T
GP-IDF--TT
H
P
F
I
E
D
F
I
F
L
K
E
AVGDNH
V
A
KQTIPS
P
A
M
-
L
H
YRGDI-----E-----YQ----P----YL----D
D
---
A
E
K
F
A
N
D
L
A
T
A
Y
Q
K
A
I
Q
A
F
Y
D
AG
C
R
Y
L
QLDDTS
W
S
YLC
S
D
E
Q
R
E
V
V
R
QRGF
D
P
E
T
L
Q
E
T
Y
K
N
L
I
N
E
A
I
KHKPA-----
D
M
--
V
-
I
T
M
-
H
I
CRGNFR
S
---
T
W
I-----AEGGY
G
P
V
A
E
T
L
--
F
GKL-NI
D
G
F
F
L
E
YDNERSGDFAP
L
K
Y
--V-T----R-PD
L
K
I
V
L
G
L
ITSKTGEL
E
D
E
A
A
I
K
A
R
I
E
E
A
S
EIV
P
-
L
S
Q
LRLSPQCGFASTEEGN----IL
T
------
E
E
E
Q
W
D
K
L
R
Y
V
V
R
L
A
N
D
IWGE
21
HHSearch
93.01
97%
-105
- C3 -
1YPX
1
?
A:
[2-367]
-
N
Q
V
A
P
F
Y
A
D
H
V
G
S
I
L
R
T
---
K
---
G
I
K
D
A
R
-
E
K
F
Q
S
G
E
I
T
A
L
E
L
R
K
I
E
N
T
E
I
K
Y
I
V
E
K
Q
K
E
V
G
L
K
S
I
T
D
G
E
F
R
R
--
W
H
F
D
F
L
E
N
L
D
G
V
E
G
Y
--------------------------------------------------------
S
V
--
K
I
T
G
P
-
I
D
F
--
T
T
H
P
F
I
E
D
F
I
F
L
K
E
A
V
G
D
N
H
V
A
K
Q
T
I
P
S
P
A
M
-
L
H
Y
R
G
D
I
-----
E
-----
Y
Q
----
P
----
Y
L
----
D
D
---
A
E
K
F
A
N
D
L
A
T
A
Y
Q
K
A
I
Q
A
F
Y
D
A
G
C
R
Y
L
Q
L
D
D
T
S
W
S
Y
L
C
S
D
E
--------
G
F
D
P
E
T
L
Q
E
T
Y
K
N
L
I
N
E
A
I
K
H
K
P
A
-----
D
M
--
V
-
I
T
M
-
H
I
C
R
G
------------------
G
Y
G
P
V
A
E
T
L
--
F
G
K
L
-
N
I
D
G
F
F
L
E
Y
D
N
E
R
---
F
A
P
L
K
Y
--
V
-
T
----
R
P
D
-
L
K
I
V
L
G
L
I
T
S
K
T
G
E
-
E
D
E
A
A
I
K
A
R
I
E
E
A
S
E
I
V
P
-
L
S
Q
L
R
L
S
P
Q
C
G
F
A
------------
T
------
E
E
E
Q
W
D
K
L
R
Y
V
V
R
L
A
N
D
I
W
G
E
1
PsiBlast_PDB
92.55
99%
-104
- C3 -
1YPX
1
?
A:
[2-367]
-
N
Q
V
A
P
F
Y
A
D
H
V
G
S
I
L
R
T
---
K
---
G
I
K
D
A
R
-
E
K
F
Q
S
G
E
I
T
A
L
E
L
R
K
I
E
N
T
E
I
K
Y
I
V
E
K
Q
K
E
V
G
L
K
S
I
T
D
G
E
F
R
R
--
W
H
F
D
F
L
E
N
L
D
G
V
E
G
Y
--------------------------------------------------------
S
V
--
K
I
T
G
P
-
I
D
F
--
T
T
H
P
F
I
E
D
F
I
F
L
K
E
A
V
G
D
N
H
V
A
K
Q
T
I
P
S
P
A
M
-
L
H
Y
R
G
D
I
-----
E
-----
Y
Q
----
P
----
Y
L
----
D
D
---
A
E
K
F
A
N
D
L
A
T
A
Y
Q
K
A
I
Q
A
F
Y
D
A
G
C
R
Y
L
Q
L
D
D
T
S
W
S
Y
L
C
S
D
E
--------
G
F
D
P
E
T
L
Q
E
T
Y
K
N
L
I
N
E
A
I
K
H
K
P
A
-----
D
M
--
V
-
I
T
M
-
H
I
C
R
G
------------------
G
Y
G
P
V
A
E
T
L
--
F
G
K
L
-
N
I
D
G
F
F
L
E
Y
D
N
E
R
---
F
A
P
L
K
Y
--
V
-
T
----
R
-
P
D
L
K
I
V
L
G
L
I
T
S
K
T
G
E
-
E
D
E
A
A
I
K
A
R
I
E
E
A
S
E
I
V
P
-
L
S
Q
L
R
L
S
P
Q
C
G
F
A
------------
T
------
E
E
E
Q
W
D
K
L
R
Y
V
V
R
L
A
N
D
I
W
G
E
34
Fugue
90.16
96%
-94
- C3 -
1YPX
1
?
A:
[2-367]
-
N
Q
V
A
P
F
Y
A
D
H
V
G
S
I
L
R
T
---
K
---
G
I
K
D
A
R
-
E
K
F
Q
S
G
E
I
T
A
L
E
L
R
K
I
E
N
T
E
I
K
Y
I
V
E
K
Q
K
E
V
G
L
K
S
I
T
D
G
E
F
R
--
R
W
H
F
D
F
L
E
N
L
D
G
V
E
G
--------------------------------------------------------
Y
S
V
--
K
I
T
G
P
-
I
D
F
--
T
T
H
P
F
I
E
D
F
I
F
L
K
E
A
V
G
D
N
H
V
A
K
Q
T
I
P
S
P
-
A
M
L
H
Y
R
G
D
I
-----
E
-----
Y
Q
----
P
----
Y
L
----
D
D
---
A
E
K
F
A
N
D
L
A
T
A
Y
Q
K
A
I
Q
A
F
Y
D
A
G
C
R
Y
L
Q
L
D
D
T
S
W
S
Y
L
C
S
D
E
G
F
--------
D
P
E
T
L
Q
E
T
Y
K
N
L
I
N
E
A
I
K
H
K
P
A
-----
D
----
M
V
I
T
M
H
I
C
R
G
G
------------------
Y
G
P
V
A
E
T
L
--
F
G
K
L
-
N
I
D
G
F
F
L
E
Y
D
N
E
R
F
A
---
P
L
K
Y
--
V
-
T
----
R
-
P
D
L
K
I
V
L
G
L
I
T
S
K
T
G
E
-
E
D
E
A
A
I
K
A
R
I
E
E
A
S
E
I
V
P
-
L
S
Q
L
R
L
S
P
Q
C
G
F
A
------------
T
------
E
E
E
Q
W
D
K
L
R
Y
V
V
R
L
A
N
D
I
W
G
E
25
HHSearch
63.11
19%
-66
* C3 *
1T7L
2
METE_THEMA
A:
[433-763]
---
L
P
L
F
P
T
T
T
I
G
S
F
P
Q
T
---
P
---
E
V
R
K
M
R
-
S
K
Y
R
K
G
E
I
S
K
E
E
Y
E
A
F
I
K
E
Q
I
K
K
A
I
E
L
Q
E
E
I
G
L
D
V
L
V
H
G
E
F
E
R
T
D
M
V
E
F
F
A
E
K
L
N
G
I
A
T
T
-----
Q
----------------------
N
-------------
G
W
V
L
S
Y
G
-
S
R
C
Y
-
R
P
P
--
I
I
Y
G
T
-
V
T
R
--
P
E
P
M
T
L
K
E
I
T
Y
A
Q
S
L
T
E
--
K
P
V
K
G
M
L
T
G
P
V
T
-
I
M
S
W
S
Y
Y
------------
R
----
E
----
D
I
-----
P
---
E
R
E
I
A
Y
Q
I
A
L
A
I
N
E
E
V
K
D
L
E
E
A
G
I
K
I
V
Q
I
D
E
P
A
F
R
E
K
A
P
I
K
K
--------
S
K
W
P
E
Y
F
E
W
A
I
N
A
F
N
L
A
A
N
A
R
P
------
E
T
--
Q
-
I
H
A
-
H
M
C
Y
S
D
F
N
------------------
E
I
I
E
Y
I
---
H
Q
L
-
E
F
D
V
I
S
I
E
A
S
R
S
K
G
E
I
I
S
A
F
E
N
--
F
K
G
----
W
-
I
-
K
Q
I
G
V
G
V
W
D
I
H
S
P
A
V
P
S
I
N
E
M
R
E
I
V
E
R
V
L
R
V
L
P
-
K
E
L
I
W
I
N
P
D
C
G
L
K
T
R
N
----------------
W
D
E
V
I
P
S
L
R
N
M
V
A
L
A
K
E
M
R
E
K
26
HHSearch
58.29
18%
-44
- C3 -
2NQ5
-
METE_STRMU
A:
[1-395]
------
L
T
K
V
S
S
L
G
Y
P
R
L
---
G
ENR
E
W
K
K
L
I
-
E
A
Y
W
A
G
K
V
S
K
N
D
L
F
A
G
A
K
E
L
R
L
D
F
L
K
K
Q
L
N
A
G
L
D
L
I
P
V
G
D
F
S
L
Y
D
H
I
L
D
L
S
V
Q
F
N
I
I
P
K
R
-----
F
AKEPID
I
D
L
Y
F
A
I
A
R
GNKENV
A
S
-------------
S
M
K
K
W
F
N
T
N
Y
H
Y
-
I
V
P
--
E
W
S
K
Q
R
P
K
L
--
N
N
N
R
L
L
D
L
Y
L
E
A
R
E
V
V
G
--
D
K
A
K
P
V
I
T
G
P
I
T
-
Y
V
A
L
S
T
-----------------------
G
V
----
E
D
---
F
T
A
A
V
K
S
L
L
P
L
Y
K
Q
V
F
T
E
L
V
K
A
G
A
S
Y
I
Q
V
D
E
P
I
F
V
T
D
E
G
K
--------------
D
Y
L
Q
A
A
K
A
V
Y
A
Y
F
A
K
E
V
P
------
D
A
--
K
-
F
I
F
-
Q
T
Y
F
E
G
L
I
------------------
D
-
S
Q
V
L
---
S
Q
L
-
P
V
D
A
F
G
L
D
F
V
Y
G
L
E
E
N
L
E
A
I
K
T
G-
A
-
F
----
K
-
G
-
K
E
I
F
A
G
V
I
D
G
R
N
I
W
S
S
D
F
V
K
T
S
A
L
L
E
T
I
E
E
Q
---
S
A
A
L
T
I
Q
P
S
C
S
L
L
H
V
P
V
T
T
KNET
D
L
D
P
V
L
R
N
G
L
A
F
A
D
E
K
L
T
E
V
K
R
L
A
E
H
L
D
G
-
27
HHSearch
56.21
17%
-44
- C3 -
1U1J
3
METE1_ARATH
A:
[2-383]
--------
A
S
H
I
V
G
Y
P
R
M
GPK
R
---
E
L
K
F
A
L
-
E
S
F
W
D
G
K
S
T
A
E
D
L
Q
K
V
S
A
D
L
R
S
S
I
W
K
Q
M
S
A
A
G
T
K
F
I
P
S
N
T
F
A
H
Y
D
Q
V
L
D
T
T
A
M
L
G
A
V
P
P
R
YG---
Y
TGGEIG
L
D
V
Y
F
S
M
A
RGNASVP
A
M
-------------
E
M
T
K
W
F
D
T
N
Y
H
Y
-
I
V
P
--
E
L
G
P
E
-
V
N
F
S
Y
A
S
H
K
A
V
N
E
Y
K
E
A
K
A
-
L
G
--
V
D
T
V
P
V
L
V
G
P
V
S
-
Y
L
L
L
S
K
-------------
A
----
A
----
K
G
VDKS
F
E
---
L
L
S
L
L
P
K
I
L
P
I
Y
K
E
V
I
T
E
L
K
A
A
G
A
T
W
I
Q
L
D
E
P
V
L
V
M
D
L
E
G
--------------
Q
K
L
Q
A
F
T
G
A
Y
A
E
L
E
S
T
L
S
------
G
L
--
N
-
V
L
V
-
E
T
Y
F
A
D
I
P
-----------------
A
E
A
Y
K
T
L
---
T
S
L
K
G
V
T
A
F
G
F
D
L
V
R
G
T
-
K
T
L
D
L
V
K
A
G
-
F
-
P
----
E
-
G
-
K
Y
L
F
A
G
V
V
D
G
R
N
I
W
A
N
D
F
A
A
S
L
S
T
L
Q
A
L
E
G
I
V
G
-
K
D
K
L
V
V
S
T
S
C
S
L
L
H
T
A
V
D
L
INET
K
L
D
D
E
I
K
S
W
M
A
F
A
A
Q
K
V
V
E
V
N
A
L
A
K
A
L
A
G
-
24
HHSearch
55.56
15%
-72
- C3 -
1U1J
6
METE1_ARATH
A:
[429-760]
---
L
P
I
L
P
T
T
T
I
G
S
F
P
Q
T
---
V
---
E
L
R
--------------
E
D
Y
V
K
A
I
K
E
E
I
K
K
V
V
D
L
Q
E
E
L
D
I
D
V
L
V
H
G
E
P
E
R
N
D
M
V
E
Y
F
G
E
Q
L
S
G
F
A
F
T
-----
A
----------------------
N
-------------
G
W
V
Q
S
Y
G
S
R
C
-
V
-
K
P
P
--
V
I
Y
G
D
-
V
S
R
--
P
K
A
M
T
V
F
W
S
A
M
A
Q
S
M
T
S
--
R
P
M
K
G
M
L
T
G
P
V
T
-
I
L
N
W
S
F
V
-----------------
R
----
N
D
----
Q
P
---
R
H
E
T
C
Y
Q
I
A
L
A
I
K
D
E
V
E
D
L
E
K
G
G
I
G
V
I
Q
I
D
E
A
A
L
R
E
G
L
P
L
R
--------
K
S
E
H
A
F
Y
L
D
W
A
V
H
S
F
R
I
T
N
C
G
V
Q
D
-----
S
T
--
Q
-
I
H
T
-
H
M
C
Y
S
H
F
N
------------------
D
I
I
H
S
I
---
I
D
M
-
D
A
D
V
I
T
I
E
N
S
R
S
---
D
E
K
L
L
S
V
--
F
-
R
EGVK
Y
-
G
-
A
G
I
G
P
G
V
Y
D
I
H
S
P
R
I
P
S
S
E
E
I
A
D
R
V
N
K
M
L
A
V
L
E
-
Q
N
I
L
W
V
N
P
D
C
G
L
K
T
R
K
----------------
Y
T
E
V
K
P
A
L
K
N
M
V
D
A
A
K
L
I
R
S
Q
28
HHSearch
54.77
16%
-50
- C3 -
1T7L
1
METE_THEMA
A:
[32-383]
------
F
T
K
A
Y
A
F
G
F
P
K
I
GEK
R
---
E
F
K
K
A
L
-
E
D
F
W
K
G
K
I
T
E
E
Q
F
E
E
E
M
N
K
L
R
M
Y
M
V
E
-
N
Y
R
K
N
V
D
V
I
P
S
N
E
L
S
Y
Y
D
F
V
L
D
T
A
V
M
V
G
A
V
P
E
R
FGEYR
G
----------------------
L
S
T
Y
F
D
M
A
RGGKA
L
E
M
T
K
F
F
N
T
N
Y
H
Y
-
L
V
P
--
E
I
E
T
E
E
F
Y
L
--
L
E
N
K
P
L
E
D
Y
L
F
F
K
S
-
K
G
--
I
E
T
A
P
W
V
I
G
P
F
T
-
F
L
Y
L
S
K
R
-----
N
GE---
W
I
----
R
----
R
P
----
N
Q
---
M
E
K
L
L
E
S
L
V
S
V
Y
K
E
V
F
E
K
L
V
E
N
G
C
K
E
I
L
V
N
E
P
A
F
V
C
D
L
E
K
--------------
A
H
W
D
L
I
L
N
V
Y
R
E
L
S
E
----------
F
--
P
-
L
T
V
-
F
T
Y
Y
D
S
V
S
------------------
D
-
Y
E
A
C
---
V
S
L
-
P
V
K
R
L
H
F
D
F
V
S
N
E
-
E
N
L
K
N
L
E
K
HG
F
-
P
----
E
-
D
-
K
K
L
V
A
G
V
I
N
G
R
Q
P
W
K
V
D
L
R
K
V
A
S
L
V
E
K
L
G
-------
A
S
A
I
S
N
S
C
P
L
F
H
L
P
V
T
L
ELEN
N
L
P
GGLKEK
L
A
F
A
K
E
K
L
E
E
L
K
M
L
K
D
F
L
E
G
-
31
HHSearch
45.81
15%
-81
- C3 -
2EJA
1
DCUP_AQUAE
A:
[118-336]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
I
K
R
V
K
E
A
Q
D
-
E
V
P
V
I
G
F
A
G
A
P
F
T
-
L
L
S
Y
L
I
E
GGASK
D
-----
F
K
S
T
K
L
F
----
M
W
----
E
N
P
K
E
Y
K
R
L
M
D
I
L
T
E
T
V
L
A
Y
L
K
E
Q
I
K
A
G
A
D
V
V
Q
I
F
D
S
W
V
N
--------------
N
L
S
L
E
D
Y
G
E
Y
V
Y
P
Y
V
N
Y
L
I
S
E
L
K
D
F
S---
D
T
--
P
-
V
I
Y
-
F
F
R
-
G
S
S
-------------------
S
F
I
D
L
A
---
V
D
Y
-
R
A
D
A
L
S
V
D
W
S
V
----
D
I
P
E
L
F
K
--
I
-
Y
------
D
-
K
-
G
F
Q
G
N
L
E
P
A
V
-
L
Y
A
S
E
E
V
I
E
E
K
T
L
G
L
L
R
R
I
P
V
K
T
R
Y
V
F
N
L
G
H
G
L
A
P
-------------------
D
M
E
L
E
K
V
K
Y
L
V
D
L
V
K
S
F
P
--
3
PsiBlast_PDB
45.53
22%
-45
- C3 -
1T7L
1
METE_THEMA
A:
[436-656]
------
F
P
T
T
T
I
G
S
F
P
Q
T
---
P
---
E
V
R
K
M
R
-
S
K
Y
R
K
G
E
I
S
K
E
E
Y
E
A
F
I
K
E
Q
I
K
K
A
I
E
L
Q
E
E
I
G
L
D
V
L
V
H
G
E
F
E
R
T
D
M
V
E
F
F
A
E
K
L
N
G
I
A
T
T
-----
Q
----------------------
N
-------------
G
W
V
L
S
Y
G
S
R
C
Y
R
P
P
I
I
Y
G
T
V
T
R
P
-
E
P
M
--
T
L
K
E
I
T
Y
A
Q
S
L
T
E
K
P
V
K
G
M
L
T
G
P
V
T
I
M
S
W
S
---
Y
Y
R
E
D
I
-----------------------------
P
---
E
R
E
I
A
Y
Q
I
A
L
A
I
N
E
E
V
K
D
L
E
E
A
G
I
K
I
V
Q
I
D
E
P
A
F
R
------
E
K
A
P
I
K
K
S
K
W
-
P
E
Y
F
-
E
W
A
I
N
A
F
N
L
A
A
N
A
R
P
------
E
T
--
Q
-
I
H
A
-
H
M
C
Y
S
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
45.15
11%
-68
- C3 -
1R3S
1
DCUP_HUMAN
A:
[135-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
A
I
T
L
T
R
Q
R
L
A
G
R
V
P
L
I
G
F
A
G
A
P
W
T
-
L
M
T
Y
M
V
E
-----
G
GGSST
M
A
Q
A
K
R
W
----
L
Y
----
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
-
G
-------------
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
G
L
A
P
V
-
P
M
I
-
I
F
A
K
D
G
-
H
------------------
F
A
L
E
E
L
---
A
Q
A
-
G
Y
E
V
V
G
L
D
W
T
V
----
A
P
K
K
A
R
E
--
C
-
V
----
G
-
K
-
T
V
T
L
Q
G
N
L
D
P
C
A
L
-
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
D
D
F
G
-
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
-------------------
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
-
32
HHSearch
44.70
13%
-73
- C3 -
2INF
-
DCUP_BACSU
A:
[127-345]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
I
K
L
L
V
N
E
Q
L
N
-
V
P
L
I
G
F
S
G
A
P
F
T
-
L
A
S
Y
M
T
E
-----
G
GPSKN
Y
N
----
K
T
K
A
F
M
Y
----
S
M
P
D
A
W
N
L
L
M
S
K
L
A
D
M
I
I
V
Y
V
K
A
Q
I
K
A
G
A
K
A
I
Q
I
F
D
S
W
V
G
--------------
A
L
N
Q
A
D
Y
R
T
Y
I
K
P
V
M
N
R
I
F
S
E
L
A
K
E
----
N
V
--
P
-
L
I
M
-
F
G
V
-
G
A
S
-------------------
H
L
A
G
D
W
---
H
D
L
-
P
L
D
V
V
G
L
D
W
R
L
----
G
I
D
E
A
R
S
--
K
------
G
-
I
-
T
K
T
V
Q
G
N
L
D
P
S
I
L
L
-
A
P
W
E
V
I
E
Q
K
T
K
E
I
L
D
Q
G
M
E
S
D
G
F
I
F
N
L
G
H
G
V
F
P
-------------------
D
V
S
P
E
V
L
K
K
L
T
A
F
V
H
E
Y
S
Q
-
17
PsiBlast_PDB
44.57
22%
-46
- C3 -
1XDJ
3
METE_THEMA
A:
[436-656]
------
F
P
T
T
T
I
G
S
F
P
Q
T
---
P
---
E
V
R
K
M
R
-
S
K
Y
R
K
G
E
I
S
K
E
E
Y
E
A
F
I
K
E
Q
I
K
K
A
I
E
L
Q
E
E
I
G
L
D
V
L
V
H
G
E
F
E
R
T
D
M
V
E
F
F
A
E
K
L
N
G
I
A
T
T
-----
Q
----------------------
N
-------------
G
W
V
L
S
Y
G
S
R
C
Y
R
P
P
I
I
Y
G
T
V
T
R
P
-
E
P
M
--
T
L
K
E
I
T
Y
A
Q
S
L
T
E
K
P
V
K
G
M
L
T
G
P
V
T
I
M
S
W
S
---
Y
Y
R
E
D
I
-----------------------------
P
---
E
R
E
I
A
Y
Q
I
A
L
A
I
N
E
E
V
K
D
L
E
E
A
G
I
K
I
V
Q
I
D
E
P
A
F
R
------
E
K
A
P
I
K
K
S
K
W
-
P
E
Y
F
-
E
W
A
I
N
A
F
N
L
A
A
N
A
R
P
------
E
T
--
Q
-
I
H
A
-
H
M
C
Y
S
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
44.17
22%
-44
- C3 -
3BQ6
1
METE_THEMA
A:
[436-656]
------
F
P
T
T
T
I
G
S
F
P
Q
T
---
P
---
E
V
R
K
M
R
-
S
K
Y
R
K
----
K
E
E
Y
E
A
F
I
K
E
Q
I
K
K
A
I
E
L
Q
E
E
I
G
L
D
V
L
V
H
G
E
F
E
R
T
D
M
V
E
F
F
A
E
K
L
N
G
I
A
T
T
-----
Q
----------------------
N
-------------
G
W
V
L
S
Y
G
S
R
C
Y
R
P
P
I
I
Y
G
T
V
T
R
P
-
E
P
M
--
T
L
K
E
I
T
Y
A
Q
S
L
T
E
K
P
V
K
G
M
L
T
G
P
V
T
I
M
S
W
S
---
Y
Y
R
E
D
I
-----------------------------
P
---
E
R
E
I
A
Y
Q
I
A
L
A
I
N
E
E
V
K
D
L
E
E
A
G
I
K
I
V
Q
I
D
E
P
A
F
R
------
E
K
A
P
I
K
K
S
K
W
-
P
E
Y
F
-
E
W
A
I
N
A
F
N
L
A
A
N
A
R
P
------
E
T
--
Q
-
I
H
A
-
H
M
C
Y
S
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
44.14
14%
-67
- C3 -
1J93
5
DCUP_TOBAC
A:
[131-352]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
L
T
I
L
R
K
E
V
N
N
Q
A
A
V
L
G
F
V
G
A
P
F
T
-
L
A
S
Y
V
V
E
GGSSK
N
-----
F
T
K
I
K
R
L
----
A
F
----
A
E
P
K
V
L
H
A
L
L
Q
K
F
A
T
S
M
A
K
Y
I
R
Y
Q
A
D
S
G
A
Q
A
V
Q
I
F
D
S
W
A
T
--------------
E
L
S
P
V
D
F
E
E
F
S
L
P
Y
L
K
Q
I
V
D
S
V
K
L
T
HP--
N
L
--
P
-
L
I
L
-
Y
A
S
-
G
S
G
-------------------
G
L
L
E
R
L
---
P
L
T
-
G
V
D
V
V
S
L
D
W
T
V
----
D
M
A
D
G
R
R
--
R
-
L
----
G
-
P
-
N
V
A
I
Q
G
N
V
D
P
G
V
L
-
F
G
S
K
E
F
I
T
N
R
I
N
D
T
V
K
K
A
G
-
K
G
K
H
I
L
N
L
G
H
G
I
K
V
-------------------
G
T
P
E
E
N
F
A
H
F
F
E
I
A
K
G
L
R
--
18
PsiBlast_PDB
43.49
22%
-45
- C3 -
1XPG
4
METE_THEMA
A:
[436-656]
------
F
P
T
T
T
I
G
S
F
P
Q
T
---
P
---
E
V
R
K
M
R
-
S
K
Y
R
K
G
E
I
S
K
E
E
Y
E
A
F
I
K
E
Q
I
K
K
A
I
E
L
Q
E
E
I
G
L
D
V
L
V
H
G
E
F
E
R
T
D
M
V
E
F
F
A
E
K
L
N
G
I
A
T
T
-----
Q
----------------------
N
-------------
G
W
V
L
S
Y
G
S
R
C
Y
R
P
P
I
I
Y
G
T
V
T
R
P
-
E
P
M
--
T
L
K
E
I
T
Y
A
Q
S
L
T
E
K
P
V
K
G
M
L
T
G
P
V
T
I
M
S
W
S
---
Y
Y
R
E
D
I
-----------------------------
P
---
E
R
E
I
A
Y
Q
I
A
L
A
I
N
E
E
V
K
D
L
E
E
A
G
I
K
I
V
Q
I
D
E
P
A
F
R
------
E
K
A
P
I
K
K
S
K
W
-
P
E
Y
F
-
E
W
A
I
N
A
F
N
L
A
A
N
A
R
P
------
E
T
--
Q
-
I
H
A
-
H
M
C
Y
S
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
43.39
22%
-44
- C3 -
1XR2
2
METE_THEMA
A:
[436-656]
------
F
P
T
T
T
I
G
S
F
P
Q
T
---
P
---
E
V
R
K
M
R
-
S
K
-----
I
S
K
E
E
Y
E
A
F
I
K
E
Q
I
K
K
A
I
E
L
Q
E
E
I
G
L
D
V
L
V
H
G
E
F
E
R
T
D
M
V
E
F
F
A
E
K
L
N
G
I
A
T
T
-----
Q
----------------------
N
-------------
G
W
V
L
S
Y
G
S
R
C
Y
R
P
P
I
I
Y
G
T
V
T
R
P
-
E
P
M
--
T
L
K
E
I
T
Y
A
Q
S
L
T
E
K
P
V
K
G
M
L
T
G
P
V
T
I
M
S
W
S
---
Y
Y
R
E
D
I
-----------------------------
P
---
E
R
E
I
A
Y
Q
I
A
L
A
I
N
E
E
V
K
D
L
E
E
A
G
I
K
I
V
Q
I
D
E
P
A
F
R
------
E
K
A
P
I
K
K
S
K
W
-
P
E
Y
F
-
E
W
A
I
N
A
F
N
L
A
A
N
A
R
P
------
E
T
--
Q
-
I
H
A
-
H
M
C
Y
S
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
42.69
22%
-49
- C3 -
3BQ5
2
METE_THEMA
A:
[436-656]
------
F
P
T
T
T
I
G
S
F
P
Q
T
---
P
---
E
V
R
K
M
R
-
S
K
-------------
F
I
K
E
Q
I
K
K
A
I
E
L
Q
E
E
I
G
L
D
V
L
V
H
G
E
F
E
R
T
D
M
V
E
F
F
A
E
K
L
N
G
I
A
T
T
-----
Q
----------------------
N
-------------
G
W
V
L
S
Y
G
S
R
C
Y
R
P
P
I
I
Y
G
T
V
T
R
P
-
E
P
M
--
T
L
K
E
I
T
Y
A
Q
S
L
T
E
K
P
V
K
G
M
L
T
G
P
V
T
I
M
S
W
S
---
Y
Y
R
E
D
I
-----------------------------
P
---
E
R
E
I
A
Y
Q
I
A
L
A
I
N
E
E
V
K
D
L
E
E
A
G
I
K
I
V
Q
I
D
E
P
A
F
R
------
E
K
A
P
I
K
K
S
K
W
-
P
E
Y
F
-
E
W
A
I
N
A
F
N
L
A
A
N
A
R
P
------
E
T
--
Q
-
I
H
A
-
H
M
C
Y
S
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
39.26
20%
0
- C- -
3RPD
-
?
A:
[14--6]
--
N
Q
A
L
L
P
T
S
T
A
G
S
L
P
K
P
---
L
---
W
L
A
E
P
E
-
T
L
W
S
P
W
K
L
Q
G
E
E
L
I
T
G
K
H
D
A
L
R
L
S
L
Q
D
Q
Q
L
A
G
I
D
I
V
S
D
G
E
Q
T
R
Q
H
F
V
T
T
F
I
E
H
L
N
G
V
D
F
S
-----
K
----------------------
R
-------------
K
I
V
K
I
R
-
D
R
Y
D
A
-
S
V
P
--
T
V
V
G
P
-
V
S
R
--
Q
K
S
V
F
V
E
D
A
K
F
L
R
K
Q
T
T
--
Q
P
I
K
W
A
L
P
G
P
M
T
-
M
I
D
T
L
Y
-------------
D
----
D
----
H
Y
----
K
S
---
R
E
K
L
A
W
E
F
A
K
I
L
N
E
E
A
K
E
L
E
A
A
G
V
D
I
I
Q
F
D
E
P
A
F
N
V
F
F
D
---------------
E
V
N
D
W
G
I
A
C
L
E
R
A
I
E
G
L
K
-------
C
--
E
-
T
A
V
-
H
I
C
Y
G
Y
G
I
K
A
N
T
D
W
K
K
T
LGS
E
W
R
Q
Y
E
E
V
F
P
K
L
---
Q
K
S
-
N
I
D
I
I
S
L
E
C
H
N
S
H
-
V
P
M
E
L
L
E
L
--
I
-
R
------
G
-
K
K
V
M
V
G
A
I
D
V
A
T
D
T
I
E
T
A
E
E
V
A
D
T
L
R
K
A
L
K
F
V
D
-
A
D
K
L
Y
P
C
T
N
C
G
M
T
P
L
S
----------------
H
Q
V
T
R
G
K
L
N
A
L
S
A
G
A
E
I
V
R
K
E
40
Fugue
33.30
12%
-26
- C2 -
4I1O
3
?
B:
[12-302]
P
L
T
L
L
M
T
S
S
T
S
F
S
E
T
I
N
Q
---
W
---
A
D
I
L
K
T
M
E
K
F
D
S
N
P
I
N
L
L
E
L
V
K
Q
F
N
L
Y
V
D
E
L
A
I
T
C
E
A
N
N
V
----------------
W
A
S
T
P
N
L
F
A
L
Y
-----
D
----------------------
N
-------------
S
G
G
---------------
E
A
I
H
G
-
H
A
F
--
V
P
Y
-
Y
K
E
S
I
V
L
R
R
L
F
T
V
D
P
N
T
--------------
F
N
L
S
-----
R
-----
F
A
----
A
----
F
E
----
G
P
---
C
Q
L
Y
C
A
A
H
A
D
S
A
W
V
K
I
Q
T
L
L
T
L
G
N
G
I
I
N
----
T
L
K
I
I
K
Q
A
Q
A
F
G
I
D
E
A
V
T
E
N
L
K
A
L
K
E
Q
F
I
A
F
Q
L
A
E
A
D
I
K
E
S
-----
L
K
--
A
-
P
S
F
-
A
--
E
P
N
K
E
S
---
E
F
F
---------
Y
P
I
D
E
K
A
L
A
K
M
N
G
Y
-
Q
L
A
T
I
C
L
E
E
L
N
S
P
K
P
S
--------------------
P
L
I
E
R
I
L
S
N
--------
K
K
F
W
K
R
I
N
S
A
F
E
-------------
S
G
V
F
K
G
R
T
D
D
----
P
A
G
------
K
I
A
K
I
R
E
W
H
Q
L
L
Q
I
S
G
-----