@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0859: (2016-03-19 )
MKIRKIAIAALSVVVAGSLLTACGGGNSKSDDNGKTKVTFWAAPNPTQVKYWDEMAKAYEKENPDVTIEVSQMKESPSSEATIQSAIASKTAPTMSENINRSFAAQLADSKAIVPLNDVKGLDDVVKERNMSETMDSWKFSDGNQYVLPVYSNPILFAWRLDTLKELGYDAPPKTYSEALEVGKKLKAKYPDKVLWAKGDLSDPTAWMRWFDFFPLYDAASKGNAFVEDGKLVADDKAGTELLTFMSELQKNKLLLASKATDPFETGTSIMADNGPWTFPNWDEKFPELKYNENYAITAPLVPDSMVNEENVATYADSKGVVMYAQATDKEKEAAMDFLKFVYNDDKNDLKFLETTNLIPARDDATENETFTAFFKENPELEVYAANVPYSIPAMDDAKYNDIQQIIGEEAWNPIVRGEKKPTKAWSDMKKAEDGVLQE
Atome Classification :
(20 SA)
.........10........20........30--........40...--..-.-..50........60----........70....-.-...80........-90.........100........110-.......120.--..-....130.----.....-.140.......150........160.......170.......180.......190.--......200.......210.......220.---..----..-.---.-------230--.-----........240.......-----------------250---.-....-----.---------.-----------260----.......270..----.....280.....-..290.......300.......310.......320.....--..330.......340........350......-.360...-....-370...-....380.....-.---.---390........400.........410.....----.--.-420.......430.......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
R
K
I
A
I
A
A
L
S
V
V
V
A
G
S
L
L
T
ACGGGNSKSD--DNG
K
T
K
V
T
F
W
AAP--NP-
T
-
Q
V
K
Y
W
D
E
M
A
K
A
Y
EK----ENP
D
V
T
I
E
V
S
Q
MKE-S-PSS
E
A
T
I
Q
S
A
I
AS-K-TAP
T
M
S
E
NI
N
R
-
S
F
A
A
Q
LADSK
A
-
I
V
P
L
N
DVK
G
L
D
--
D
V
-
V
K
ER
N
M
S
E
----
T
M
D
SW-KFSDG
N
Q
Y
V
L
P
VY-SN
P
I
L
F
A
W
R
L
D
T
L
K
E
LGYDAP
P
K
T
Y
S
E
A
L
E
V
G
K
K
L
K
AKYPD
K
--
V
L
WAKGDLS
D
P
T
A
W
M
R
W
F
D
FFPLYDAASKG---N
A
----
F
V-E---D-------G----
K
-----
L
V
ADDKA
G
T
E
L
L
T
F
M
S
E
L-----------------QKN---
K
-
L
L
L
A-----S---------K-----------ATD----PFETGTSIMADN----GPWTFP
N
W
D
EKFP-ELKYNE
N
Y
A
I
TAPLVPDSMVNE
E
N
V
ATYADSK
G
V
V
M
Y
AQA--TD
K
E
K
E
A
A
M
D
F
L
K
-
F
V
YNDDKN
D
L
K
F
L
ETTNL-IPARDDA-TENE-
T
F
T
A
FF-KENP
E
L
E
V
Y
AAN-V---P---Y-SIPAMDDA
K
Y
--
N
D
I
Q
Q
I
I
G
E
EAWNPIVR----G--E-KKP
T
K
A
W
S
D
M
K
K
AEDGVLQE---
1
PsiBlast_PDB
94.53
96%
-65
- C1 -
4GQO
-
?
A:
[29-432]
------------------------------------
K
T
K
V
T
F
W
A
A
P
--
N
P
-
T
-
Q
V
K
Y
W
D
E
M
A
K
A
Y
E
K
----
E
N
P
D
V
T
I
E
V
S
Q
M
K
E
-
S
-
P
S
S
E
A
T
I
Q
S
A
I
A
S
-
K
-
T
A
P
T
M
S
E
N
I
N
R
-
S
F
A
A
Q
L
A
D
S
K
A
-
I
V
P
L
N
D
V
K
G
L
D
--
D
V
-
V
K
E
R
N
M
S
E
----
T
M
D
S
W
-
K
F
S
D
G
N
Q
Y
V
L
P
V
Y
-
S
N
P
I
L
F
A
W
R
L
D
T
L
K
E
L
G
Y
D
A
P
P
K
T
Y
S
E
A
L
E
V
G
K
K
L
K
A
K
Y
P
D
K
--
V
L
W
A
K
G
D
L
S
D
P
T
A
W
M
R
W
F
D
F
F
P
L
Y
D
A
A
S
K
G
---
N
A
----
F
V
-
E
---
D
-------
G
----
K
-----
L
V
A
D
D
K
A
G
T
E
L
L
T
F
M
S
E
L
-----------------
Q
K
N
---
K
-
L
L
L
A
-----
S
---------
K
-----------
A
T
D
----
P
F
E
T
G
T
S
I
M
A
D
N
----
G
P
W
T
F
P
N
W
D
E
K
F
P
-
E
L
K
Y
N
E
N
Y
A
I
T
A
P
L
V
P
D
S
M
V
N
E
E
N
V
A
T
Y
A
D
S
K
G
V
V
M
Y
A
Q
A
--
T
D
K
E
K
E
A
A
M
D
F
L
K
-
F
V
Y
N
D
D
K
N
D
L
K
F
L
E
T
T
N
L
-
I
P
A
R
D
D
A
-
T
E
N
E
-
T
F
T
A
F
F
-
K
E
N
P
E
L
E
V
Y
A
A
N
-
V
---
P
---
Y
-
S
I
P
A
M
D
D
A
K
Y
--
N
D
I
Q
Q
I
I
G
E
E
A
W
N
P
I
V
R
----
G
--
E
-
K
K
P
T
K
A
W
S
D
M
K
K
A
E
D
G
V
L
Q
----
118
HHSearch
61.57
19%
-42
- C1 -
3K01
1
?
A:
[24-410]
---------------------------------
V
E
L
S
G
T
V
T
F
W
D
T
S
--
N
E
-
A
-
E
K
A
T
Y
Q
A
L
A
E
G
F
E
K
----
E
H
P
K
V
D
V
K
Y
V
N
V
P
F
---
G
E
A
N
A
K
F
K
N
A
A
G
G
-
N
S
G
A
P
D
V
M
R
-
T
E
V
-
A
W
V
A
D
F
A
S
I
G
Y
-
L
A
P
L
D
G
T
P
A
L
D
--
D
---
G
S
D
H
L
P
Q
----
A
A
A
S
T
-
R
Y
-
E
G
K
T
Y
A
V
P
Q
V
-
I
D
T
L
A
L
F
Y
N
K
E
L
L
T
K
A
G
V
E
-
V
P
G
S
V
A
E
L
K
T
A
A
A
E
I
T
E
K
T
G
A
-----
T
G
L
Y
L
R
G
D
D
P
Y
---
W
--
F
L
-
P
Y
L
Y
G
E
G
G
----
D
----
L
V
-
D
E--
K
N------
K
----
T
-----
V
T
V
D
D
E
A
G
V
R
A
Y
R
V
I
K
D
L
-----------------
V
D
S
---
K
-
A
A
I
T
-----
D
ASD
G
W
N
---
N
-----------
M
Q
N
----
A
F
K
S
G
K
V
A
M
M
V
N
----
G
P
W
A
I
E
D
V
K
A
G
A
R
-
F
K
-
D
A
G
N
L
G
V
A
P
V
P
A
G
S
A
G
Q
-----
G
S
P
Q
G
G
W
N
L
S
V
Y
A
G
S
--
K
N
--
L
D
A
S
Y
A
F
V
K
-
Y
M
S
S
A
K
-
V
Q
Q
Q
T
T
E
K
L
S
L
-
L
P
T
R
T
S
V
-
Y
E
V
P
-
S
V
A
D
-----
N
E
M
V
K
F
F
K
P
A
-
V
---
D
---
K
-
A
V
E
R
P
W
I
A
E
G
--
N
A
L
F
E
P
I
R
L
-
Q
M
A
N
V
L
S
----
G
--
E
-
T
S
P
D
E
A
A
A
N
T
G
D
A
Y
R
K
L
L
K
D
---
117
HHSearch
60.92
17%
-43
- C1 -
3UOR
-
?
A:
[27-412]
------------------------------------
K
T
T
V
R
F
W
A
M
G
--
K
----
E
A
E
V
V
A
E
L
V
A
D
F
E
K
----
Q
N
P
T
I
H
V
D
V
Q
N
I
P
M
---
T
A
A
H
E
K
L
L
T
A
F
A
A
-
D
-
G
L
P
D
V
C
Q
-
L
G
N
-
T
W
L
P
E
F
A
L
L
D
T
-
L
E
P
M
Q
P
Y
V
A
R
S
--
K
I
V
D
P
A
D
Y
F
P
G
----
V
W
D
T
N
-
L
V
-
D
G
T
L
Y
G
V
P
W
Y
-
V
D
T
R
L
L
F
Y
R
K
D
L
L
R
E
A
G
Y
S
Q
M
P
K
T
W
A
E
M
E
Q
V
M
A
A
I
K
R
K
V
G
P
---
D
R
Y
A
I
L
M
P
L
N
-
E
F
-
E
---
Q
Q
L
S
-
F
A
L
Q
Q
D
D
---
R
L
----
L
R
-
D
H--
D
-------
N
----
Y
-----
G
N
F
R
G
A
G
F
R
K
A
L
G
F
Y
D
N
M
-----------------
Y
Q
Q
---
G
-
W
A
P
K
-----
V
SETQVS---
N
-----------
V
W
Y
----
E
F
F
N
G
Y
Y
A
F
Y
L
S
----
G
P
W
N
V
R
E
F
K
L
R
Q
P
P
G
M
E
--
G
N
W
G
T
A
P
L
P
G
P
N
G
L
-----
G
A
G
I
A
G
G
S
S
L
V
I
F
K
S
S
--
Q
H
--
K
D
A
S
W
K
L
I
E
-
Y
L
S
Q
P
Q
-
V
Q
A
R
F
H
A
I
I
G
D
-
L
P
P
R
R
S
T
-
W
K
L
P
-
S
L
A
N
-----
D
A
L
A
H
A
F
G
D
Q
-
L
---
E
---
R
-
V
K
A
T
P
K
V
L
E
W
--
E
R
I
V
Q
E
M
R
L
-
V
T
E
R
V
V
R
----
G
--
G
-
Q
S
H
D
A
A
V
Q
E
L
D
Q
R
V
D
E
I
L
A
----
119
HHSearch
59.68
20%
-39
- C1 -
1EU8
9
MALE_THELN
A:
[3-406]
------------------------------------
E
G
K
I
V
F
A
V
G
G
--
A
P
-
N
-
E
I
E
Y
W
K
G
V
I
A
E
F
E
K
----
K
Y
P
G
V
T
V
E
L
K
R
Q
A
T
-
D
T
E
Q
R
R
L
D
L
V
N
A
L
R
G
K
S
-
S
D
P
D
V
F
L
-
M
D
V
-
A
W
L
G
Q
F
I
A
S
G
W
-
L
E
P
L
D
D
Y
V
Q
K
D
--
N
Y
-
D
L
S
V
F
F
Q
S
----
V
I
N
L
A
D
K
Q
-
G
G
K
L
Y
A
L
P
V
Y
-
I
D
A
G
L
L
Y
Y
R
K
D
L
L
E
K
Y
G
Y
S
K
P
P
E
T
W
Q
E
L
V
E
M
A
Q
K
I
Q
S
G
E
R
E
T
NP
N
F
W
G
F
V
W
Q
G
K
Q
-
Y
E
G
L
V
C
D
F
V
-
E
Y
V
Y
S
N
G
G
---
S
L
----
G
E
F
K
---
D
-------
G
K
W
--
V
-----
P
T
L
N
K
P
E
N
V
E
A
L
Q
F
M
V
D
L
-----------------
I
H
K
---
Y
-
K
I
S
P
P----
N
TYTEMTE
E
-
P
-----------
V
R
L
----
M
F
Q
Q
G
N
A
A
F
E
R
N
----
W
P
Y
A
W
G
L
H
N
A
D
D
S
-
P
V
K
--
G
K
V
G
V
A
P
L
P
H
F
P
G
H
K
----
S
A
A
T
L
G
G
W
H
I
G
I
S
K
Y
S
--
D
N
--
K
A
L
A
W
E
F
V
K
-
F
V
E
S
Y
S
-
V
Q
K
G
F
A
M
N
L
G
W
-
N
P
G
R
V
D
V
-
Y
D
D
P
-
A
V
V
----
S
K
S
P
H
L
K
E
L
R
A
V
-
F
---
E
---
N
-
A
V
P
R
P
I
V
P
Y
Y
--
P
Q
L
S
E
I
I
Q
K
-
Y
V
N
S
A
L
A
----
G
--
K
-
I
S
P
Q
E
A
L
D
K
A
Q
K
E
A
E
E
L
V
K
----
122
HHSearch
56.80
19%
-46
- C1 -
3QUF
3
?
A:
[27-411]
----------------------------------
G
G
K
T
K
I
S
F
Y
S
Y
F
--
K
-----
D
N
Q
I
G
E
V
V
K
G
F
E
K
----
K
N
P
D
I
T
L
D
V
Q
Y
G
Q
D
-
P
-
A
Q
Y
I
S
T
L
Q
T
R
L
A
G
-
G
-
K
P
P
T
I
F
N
-
L
T
M
-
D
N
R
T
D
V
M
K
S
G
A
-
A
L
D
I
S
G
E
D
F
L
D
--
G
------
I
D
D
T
----
N
F
A
L
F
-
Q
Q
-
D
G
K
T
Y
G
M
P
V
S
-
A
W
V
G
A
F
F
Y
N
K
D
I
L
K
K
A
G
Y
D
K
F
P
K
T
W
D
E
F
I
E
M
G
K
K
I
N
S
N
G
S
T
----
A
F
L
E
D
F
--
N
T
Q
I
A
G
S
F
T
G
L
L
A
S
Y
Y
G
E
Q
G
K
S--
G
D
----
L
D
-
A
D
I
W
S
-------
G
----
K
-----
S
T
F
T
K
D
-
W
T
P
V
F
K
R
W
E
A
A
-----------------
A
K
A
---
G
-
V
I
P
Q
-----
K
SVGLS
A
D
--
Q
-----------
V
K
Q
----
E
F
V
S
G
N
L
G
V
M
R
S
----
G
P
W
D
L
P
D
L
Q
K
S
-----
D
--
I
D
F
G
V
A
P
F
P
A
Y
S
K
E
D
--
G
Q
W
I
N
G
G
P
D
Q
G
F
A
I
A
S
R
A
S
D
K
E
--
K
A
A
A
K
K
F
L
A
-
Y
L
N
S
E
E
-
G
L
E
A
F
T
S
A
A
G
T
-
L
S
L
S
S
K
Y
-
N
A
E
P
-
P
--
A
E
L
---
K
D
V
V
D
N
Y
F
K
Q
-
N
---
K
---
F
Y
W
V
N
W
P
K
S
P
T
----
V
M
S
T
E
G
I
A
-
Q
Q
Q
K
I
V
Q
----
G
--
Q
-
I
S
A
K
D
A
A
K
A
L
D
A
K
W
A
T
L
------
124
HHSearch
56.39
18%
-38
- C1 -
2GH9
1
?
A:
[2-379]
--------------------------------------
K
I
T
V
W
T
H
F
--
G
G
-
P
-
E
L
E
W
L
K
E
Q
A
R
T
F
E
R
-----
T
S
G
T
K
V
E
V
V
E
V
P
F
---
A
E
I
K
Q
K
F
I
L
G
A
P
Q
-
G
-
Q
A
A
D
L
V
V
T
V
P
H
-
D
W
V
G
E
M
A
Q
A
G
V
-
L
E
P
V
G
K
Y
V
T
Q
---
A
--
Y
L
A
D
L
Q
G
V
----
A
V
E
A
F
-
T
F
-
G
G
R
L
M
G
L
P
A
F
-
A
E
S
V
A
L
I
Y
N
K
K
Y
V
K
E
-----
P
P
R
T
W
E
E
F
L
A
L
A
Q
K
L
T
T
G
A
T
------
F
G
F
L
Y
N
I
G
D
P
Y
F
--
N
F
----
G
F
F
K
A
F
G
A
---
E
N
----
V
F
-
A
K
--
D
A
K
G
N
L
D
P
T
----
K
-----
L
L
I
G
G
E
V
G
E
K
A
L
Q
F
I
K
D
L
-----------------
R
F
K
---
Y
N
L
V
P
E
-----
G
VD
Y
G
-----
V
-----------
A
D
G
----
A
F
K
D
G
A
L
A
M
I
L
N
----
G
P
W
A
L
G
D
Y
K
K
A
-----
K
--
V
D
F
G
I
A
P
F
P
V
P
P
G
A
K
--
N
P
W
G
P
F
L
G
V
Q
G
V
V
V
N
A
Y
S
--
K
N
--
K
T
Q
A
V
N
F
A
K
-
T
L
V
T
G
R
-
N
L
V
A
F
N
Q
A
G
G
R
-
I
P
V
S
K
S
A
-
V
K
Q
L
-
E
-------
K
D
P
V
V
A
G
F
S
K
V
-
F
---
P
---
L
-
G
A
P
M
P
N
I
P
E
M
--
G
K
V
W
G
P
W
G
N
-
A
I
S
L
A
I
Q
----
R
--
P
D
S
N
V
K
K
I
V
E
D
M
V
A
E
I
K
K
A
I
G
----
116
HHSearch
53.41
19%
-38
- C1 -
3VXB
4
?
A:
[38-434]
--------------------------------------
T
I
T
A
M
V
Y
G
--
D
D
---
A
V
K
V
Q
D
K
A
A
S
R
F
N
A
S
A
E
A
K
K
A
N
A
K
V
K
M
E
R
I
P
A
---
S
D
Y
P
A
K
L
R
T
A
M
G
S
-
P
-
N
A
P
D
I
F
F
N
W
G
G
-
G
S
I
K
A
Y
K
E
A
G
Q
-
L
V
D
L
T
D
V
I
K
S
D
--
E
V
-
L
S
T
G
F
L
P
S
----
V
V
A
A
G
-
S
L
-
D
G
H
E
Y
G
I
P
M
R
G
M
Q
P
V
L
L
F
Y
N
K
S
V
F
A
E
H
K
L
T
-
P
P
T
T
W
D
Q
L
L
D
N
V
A
K
L
K
K
A
G
V
T
----
P
F
A
L
G
--
G
V
E
I
W
P
E
-
L
-
M
W
L
E
Y
L
V
D
R
I
G
G
---
P
Q
----
V
F
-
D
K
I
R
N
-------
G
----
D
A----
S
G
W
G
D
P
A
V
L
K
A
A
Q
T
V
K
Q
L
-----------------
V
D
E
---
G
-
A
F
G
K
-----
G
FSSVSYNNG
G
-----------
A
P
A
----
L
L
A
K
G
K
A
G
M
H
L
M
----
G
S
W
E
Y
S
T
Q
L
G
K
F
P
-
D
F
A
-
K
K
D
L
G
W
C
A
F
P
S
F
E
G
G
A
G
D
I
R
N
V
V
G
N
P
C
N
Y
W
S
V
N
A
R
T
--
G
N
--
K
D
G
A
I
A
F
L
R
-
D
C
A
S
E
A
-
Y
T
K
D
L
I
-
D
N
G
D
-
V
P
T
T
T
I
A
-
E
N
M
L
-
D
S
S
-----
P
N
P
E
F
A
K
F
Q
Y
Q
L
V
Q
K
A
P
---
N
-
F
T
L
S
W
D
Q
A
V
D
--
P
D
W
Q
Q
P
M
L
T
-
E
I
N
K
L
F
V
----
G
--
K
-
S
S
P
E
Q
F
V
S
A
L
K
G
-----------
121
HHSearch
53.37
13%
-37
- C1 -
2UVJ
1
?
A:
[5-404]
------------------------------------
E
V
N
L
R
M
S
W
W
G
--
G
N
-
G
-
R
H
Q
V
T
L
K
A
L
E
E
F
H
K
----
Q
H
P
N
I
N
V
K
A
E
Y
T
G
W
---
D
G
H
L
S
R
L
T
T
Q
I
A
G
-
G
-
T
E
P
D
V
M
Q
-
T
N
W
-
N
W
L
P
I
F
S
K
D
G
T
G
F
Y
N
L
F
S
V
K
E
Q
----
L
-
D
L
A
Q
F
D
P
K
----
E
L
Q
Q
T
-
T
V
-
N
G
K
L
N
G
I
P
I
S
-
V
T
A
R
I
F
Y
F
N
D
A
T
W
A
K
A
G
L
E
-
Y
P
K
T
W
D
E
L
L
A
A
G
K
V
F
K
E
K
L
G
D
---
Q
Y
Y
P
V
V
L
E
H
Q
D
-
T
L
A
L
---
I
R
S
Y
M
T
Q
K
Y
N
I
---
P
T
----
I
D
-
E
---
A
N------
K
----
K
-----
F
A
Y
S
P
E
Q
W
V
E
F
F
T
M
Y
K
T
M
-----------------
V
D
N
---
H
-
V
M
P
S
-----
T
---------
K
Y
Y
A
S
F
GKSNMY
E
M
K
----
P
W
I
N
G
E
W
A
G
T
Y
M
----
W
N
S
T
I
T
K
Y
S
D
N
L
--
T
K
P
--
A
K
L
V
L
G
P
Y
P
M
L
P
G
A
K
--
D
A
G
L
F
F
K
P
A
Q
M
L
S
I
G
K
S
T
--
K
H
--
P
Q
E
S
A
M
L
I
N
-
F
L
L
N
S
K
E
G
V
E
A
L
G
L
E
-
R
G
-
V
P
L
S
A
T
A
-
V
T
Q
L
-
R
A
S
G
V
I
K
D
E
D
P
S
V
A
G
L
N
M
A
-
L
---
E
---
L
-
P
H
K
M
T
T
S
P
Y
F
DD
P
Q
I
V
S
L
F
G
D
-
A
I
Q
Y
I
D
Y
----
G
--
Q
-
K
T
V
Q
E
T
A
E
Y
F
N
K
Q
G
D
R
I
L
K
----
128
HHSearch
53.04
17%
-30
* C1 *
2GHA
1
?
A:
[3-374]
-------------------------------------
P
K
L
T
I
W
C
S
E
-----
K
-
Q
V
D
I
L
Q
K
L
G
E
E
F
K
A
----
K
Y
-
G
V
E
V
E
V
Q
Y
V
N
F
---
Q
D
I
K
S
K
F
L
T
A
A
P
E
-
G
-
Q
G
A
D
I
I
V
-
G
A
H
-
D
W
V
G
E
L
A
V
N
G
L
-
I
E
P
I
P
N
F
S
D
L
K
--
N
------
F
Y
E
T
----
A
L
N
A
F
-
S
Y
-
G
G
K
L
Y
G
I
P
Y
A
-
M
E
A
I
A
L
I
Y
N
K
D
Y
V
P
E
-----
P
P
K
T
M
D
E
L
I
E
I
A
K
Q
I
D
E
E
F
G
G
---
E
V
R
G
F
I
T
S
A
A
-
E
F
---
Y
-
Y
I
-
A
P
F
I
F
G
Y
G
G
---
Y
V
----
F
K
-
Q
---
T
EKGLDV-
N
----
D
-----
I
G
L
A
N
E
G
A
I
K
G
V
K
L
L
K
R
L
-----------------
V
D
E
---
G
-
I
L
D
P
-----
S
DN
Y
Q
-----
I
-----------
M
D
S
----
M
F
R
E
G
Q
A
A
M
I
I
N
----
G
P
W
A
I
K
A
Y
K
D
A
-----
G
--
I
D
Y
G
V
A
P
I
P
D
L
E
P
G
V
---
P
A
R
P
F
V
G
V
Q
G
F
M
V
N
A
K
S
--
P
N
--
K
L
L
A
I
E
F
L
T
-
S
F
I
A
K
K
E
T
M
Y
R
I
Y
L
G
D
P
R
-
L
P
S
R
K
D
V
-
L
E
L
V
---
K
D
-----
N
P
D
V
V
G
F
T
L
S
-
A
---
A
---
N
-
G
I
P
M
P
N
V
P
Q
M
--
A
A
V
W
A
A
M
N
D
-
A
L
N
L
V
V
N
----
G
--
K
-
A
T
V
E
E
A
L
K
N
A
V
E
R
I
K
A
Q
I
Q
----
120
HHSearch
52.62
15%
-32
- C1 -
2ZYO
1
?
A:
[13-393]
-------------------------------KS
E
G
K
P
D
K
L
V
V
W
E
N
A
--
D
D
G
V
-
Q
L
N
N
T
K
K
W
A
G
E
F
T
K
----
K
-
T
G
I
Q
V
E
V
V
P
V
A
L
---
L
K
Q
Q
E
K
L
T
L
D
G
P
A
-
G
-
K
G
A
D
L
V
T
-
W
P
H
-
D
R
L
G
E
A
V
T
K
G
L
-
L
Q
P
I
Q
V
D
N
S
V
K
-------
N
Q
F
D
D
V
----
A
M
K
A
L
-
T
Y
-
G
G
K
L
Y
G
L
P
K
A
-
I
E
S
V
A
L
I
Y
N
K
K
L
M
G
Q
-----
V
P
A
T
Y
D
E
L
F
Q
Y
A
K
A
N
N
K
P
D
E
Q
----
K
Y
G
V
L
F
E
A
N
-
N
F
Y
--
Y
T
---
Y
F
L
F
A
A
K
G
A
---
A
V
----
F
K
-
E
Q--
D
GTLDP--
N
----
E
-----
I
G
L
N
S
P
E
A
V
Q
G
M
N
E
V
Q
K
W
-----------------
F
T
E
---
A
-
R
L
P
Q
-----
S
LK
A
D
-----
T
-----------
V
N
G
----
L
F
K
S
G
K
V
A
A
V
I
N
----
G
P
W
A
I
K
D
Y
Q
A
A
-----
G
--
I
N
V
G
V
A
P
L
P
K
I
D
G
K
D
----
A
Q
T
F
I
G
V
K
G
W
Y
L
S
A
Y
S
--
K
Y
--
P
K
Y
A
T
E
L
M
Q
-
F
L
T
S
K
E
-
A
L
A
S
R
F
K
E
T
G
E
-
I
P
P
Q
K
E
L
-
L
N
D
P
-
M
I
K
-----
N
N
P
V
V
N
G
F
A
K
Q
-
A
---
S
---
K
-
G
V
P
M
P
S
I
P
E
M
--
G
V
V
W
E
P
I
N
N
-
A
H
T
F
V
A
Q
----
G
--
K
-
Q
T
P
E
Q
A
L
N
D
A
V
K
I
M
K
E
K
I
Q
----
125
HHSearch
52.12
21%
-36
- C1 -
3WOA
1
MALE_ECOLI (first)
A:
[24-416]
E
K
K
K
N
E
L
G
L
S
Q
-
E
S
V
A
D
K
M
G
M
G
Q
S
G
S
G
M
-----
K
I
E
E
G
K
L
V
I
W
I
N
G
--
D
K
---
G
Y
N
G
L
A
E
V
G
K
K
F
E
K
----
D
-
T
G
I
K
V
T
V
E
H
P
-----
D
K
L
E
E
K
F
P
Q
V
A
A
T
-
G
-
D
G
P
D
I
I
F
-
W
A
H
-
D
R
F
G
G
Y
A
Q
S
G
L
-
L
A
E
I
T
P
D
K
A
F
-------
Q
D
K
L
Y
P
F
----
T
W
D
A
V
-
R
Y
-
N
G
K
L
I
A
Y
P
I
A
-
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
-----
P
P
K
T
W
E
E
I
P
A
L
D
K
E
L
K
A
K
G
K
S
----
A
L
M
F
N
--
L
Q
E
P
Y
F
--
T
---
W
P
-
L
I
A
A
D
G
G
---
Y
A
----
F
K
-
Y
E--
N
-------
G
----
K
YDIKD
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
-----------------
I
K
N
---
K
-
H
M
N
A
-----
D
TD
Y
S
-----
I
-----------
A
E
A
----
A
F
N
K
G
E
T
A
M
T
I
N
----
G
P
W
A
W
S
N
I
D
T
S
-----
K
--
V
N
Y
G
V
T
V
L
P
T
F
K
G
Q
P
----
S
K
P
F
V
G
V
L
S
A
G
I
N
A
A
S
--
P
N
--
K
E
L
A
K
E
F
L
E
N
Y
L
L
T
D
E
-
G
L
E
A
V
N
K
D
K
P
L
G
A
V
A
L
K
S
Y
-
E
-
E
E
--
L
-----
A
K
D
P
R
I
A
A
T
M
E
N
-
A
---
Q
---
K
-
G
E
I
M
P
N
I
P
Q
M
--
S
A
F
W
Y
A
V
R
T
-
A
V
I
N
A
A
S
----
G
--
R
-
Q
T
V
D
E
A
L
K
D
A
Q
T
-----------
133
HHSearch
52.07
20%
-34
- C1 -
3DM0
2
GBLPA_ARATH (first)
A:
[3-389]
-----------------------------------
E
E
G
K
L
V
I
W
I
N
G
--
D
--
K
-
G
Y
N
G
L
A
E
V
G
K
K
F
E
K
----
D
-
T
G
I
K
V
T
V
E
H
P
-----
D
K
L
E
E
K
F
P
Q
V
A
A
T
-
G
-
D
G
P
D
I
I
F
-
W
A
H
-
D
R
F
G
G
Y
A
Q
S
G
L
-
L
A
E
I
T
P
A
A
A
F
-------
Q
D
K
L
Y
P
F
----
T
W
D
A
V
-
R
Y
-
N
G
K
L
I
A
Y
P
I
A
-
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
-----
P
P
K
T
W
E
E
I
P
A
L
D
K
E
L
K
A
K
G
K
S
----
A
L
M
F
N
--
L
Q
E
P
Y
F
-
T
W
-----
P
L
I
A
A
D
G
G
---
Y
A
----
F
K
-
Y
E--
N
GKYDI--
K
----
D
-----
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
-----------------
I
K
N
---
K
-
H
M
N
A
-----
D
TD
Y
S
-----
I
-----------
A
E
A
----
A
F
N
K
G
E
T
A
M
T
I
N
----
G
P
W
A
W
S
N
I
D
T
S
-----
A
--
V
N
Y
G
V
T
V
L
P
T
F
K
G
Q
P
----
S
K
P
F
V
G
V
L
S
A
G
I
N
A
A
S
--
P
N
--
K
E
L
A
K
E
F
L
E
N
Y
L
L
T
D
E
-
G
L
E
A
V
N
K
D
K
P
L
-
G
A
V
A
L
K
S
-
Y
E
E
E
-
L
------
A
K
D
P
R
I
A
A
T
M
E
N
-
A
---
Q
---
K
-
G
E
I
M
P
N
I
P
Q
M
--
S
A
F
W
Y
A
V
R
T
-
A
V
I
N
A
A
S
----
G
--
R
-
Q
T
V
D
A
A
L
A
A
A
Q
T
N
A
A
A
G
L
V
----
115
Fugue
51.84
20%
-35
- C1 -
4R2F
1
?
A:
[38-431]
-------------------------------------
G
A
I
K
F
W
D
M
P
WA
T
P
-
A
-
Y
N
D
A
A
K
K
I
A
E
G
F
S
G
----
A
N
S
K
A
T
Y
Q
I
I
Q
W
N
-----
N
F
Y
Q
T
F
S
S
A
I
A
S
-
K
-
T
G
P
A
V
S
-
T
G
G
G
-
F
Q
A
F
Q
F
E
E
Q
G
Q
-
I
A
Y
A
D
K
V
--
I
E
--
K
L
-
K
S
N
G
Q
F
D
D
FLPG
V
V
E
P
F
-
K
T
S
K
G
-
Y
V
A
V
P
W
Q
-
L
D
I
R
P
L
W
Y
R
K
S
L
F
E
K
A
G
V
G
V
P
T
-
D
W
A
S
L
L
E
A
G
K
K
L
K
G
V
G
A
----
V
G
F
A
T
G
S
G
A
G
N
N
I
G
N
H
L
M
I
M
M
M
L
N
---
N
G
G
---
G
V
----
F
T
-
K
---
D
-------
G
----
E
-----
L
D
V
L
N
D
R
N
V
E
A
V
E
F
L
L
E
L
-----------------
V
S
N
---
G
-
V
I
D
P
-----
A
---------
A
-----------
V
S
Y
----
T
T
D
N
L
N
A
Q
W
K
D
S
KAA
Y
G
M
L
T
L
-----
G
V
P
-
E
R
V
G
D
T
S
G
D
I
V
V
A
S
P
I
A
G
P
H
G
D
K
A
A
L
I
F
P
N
N
--
I
M
M
Y
T
N
T
--
P
S
--
Q
E
A
S
E
E
F
V
V
-
Y
-
Y
L
G
K
L
K
E
L
W
Q
Q
K
L
M
N
A
-
L
P
V
F
K
S
I
-
T
E
M
P
-
E
F
T
A
D
--
P
N
N
V
K
I
V
N
E
Y
V
P
-
I
---
A
---
K
-
T
F
A
S
Q
G
T
A
L
S
--
A
N
L
A
A
L
D
G
G
Q
A
L
N
Q
F
T
Q
T
V
L
T
G
--
K
-
T
D
A
K
S
A
L
T
A
F
D
T
G
L
K
S
V
L
K
K
---
5
PsiBlast_PDB
51.52
25%
-46
* C2 *
3QUF
2
?
A:
[27-324]
----------------------------------
G
G
K
T
K
I
S
F
Y
S
Y
F
--
K
D
-
N
-
Q
I
---
G
E
V
V
K
G
F
E
K
----
K
N
P
D
I
T
L
D
V
Q
Y
G
Q
D
-
P
-
A
Q
Y
I
S
T
L
Q
T
R
L
A
G
-
G
-
K
P
P
T
I
F
-
N
L
T
M
-
D
N
R
T
D
V
M
K
S
G
A
-
A
L
---
D
I
S
G
E
D
FL
D
G
-
I
D
D
T
N
F
A
L
----
F
Q
------
Q
D
G
K
T
Y
G
M
P
V
S
-
A
W
V
G
A
F
F
Y
N
K
D
I
L
K
K
A
G
Y
D
K
F
P
K
T
W
D
E
F
I
E
M
G
K
K
I
N
S
---------------
N
G
S
T
A
F
L
E
--
D
F
N
T
Q
I
A
G
S
F
T
G
L
L
A
S
Y
----
Y
G
-
E
---
Q
-------
G
----
K
SGD--
L
D
A
D
I
W
S
G
K
S
--
T
F
T
K
D
W
T
P
V
F
K
R
W
E
A
A
A
K
A
GVIP
Q
K
S
---
V
-
G
L
S
A
-----
D
---------
Q
-----------
V
K
Q
----
E
F
V
S
G
N
L
G
V
M
R
S
----
G
P
W
D
L
P
D
L
Q
-------
K
S
D
I
D
F
G
V
-
A
P
F
P
A
Y
S
K
E
D
G
Q
W
I
N
G
G
P
D
-
Q
G
F
A
I
A
S
R
A
--
S
D
K
E
K
A
A
A
K
K
F
L
A
-
Y
L
-------------------------------------------------------------------------------------------------------------------------
127
HHSearch
50.15
17%
-36
- C1 -
1ELJ
4
MALE_PYRFU
A:
[4-380]
-----------------------------------
E
E
G
K
V
V
I
W
H
A
M
--
Q
P
-
N
-
E
L
E
V
F
Q
S
L
A
E
E
Y
M
A
----
L
C
P
E
V
E
I
V
F
E
Q
K
P
-----
N
L
E
D
A
L
K
A
A
I
P
T
-
G
-
Q
G
P
D
L
F
I
-
W
A
H
-
D
W
I
G
K
F
A
E
A
G
L
-
L
E
P
I
D
E
Y
V
T
E
---
D
--
L
L
N
E
F
A
P
M
----
A
Q
D
A
M
-
Q
Y
-
K
G
H
Y
Y
A
L
P
F
A
-
A
E
T
V
A
I
I
Y
N
K
E
M
V
S
E
-----
P
P
K
T
F
D
E
M
K
A
I
M
E
K
Y
Y
D
P
A
N
E
----
K
Y
G
I
A
W
P
I
N
--
A
---
Y
--
F
I
S
A
I
A
-
Q
A
F
G
---
G
Y
----
Y
F
-
D
D--
K
T------
E
----
Q
-----
P
G
L
D
K
P
E
T
I
E
G
F
K
F
F
F
T
E
-----------------
I
W
P
---
Y
-
M
A
P
T
G
D
Y
--
N
---------
T
-----------
Q
Q
S
----
I
F
L
E
G
R
A
P
M
M
V
N
----
G
P
W
S
I
N
D
V
K
K
A
-----
G
--
I
N
F
G
V
V
P
L
P
P
I
I
K
D
G
K
E
Y
W
P
R
P
Y
G
G
V
K
L
I
Y
F
A
A
G
I
--
K
N
--
K
D
A
A
W
K
F
A
K
-
W
L
T
T
S
E
E
S
I
K
T
L
A
L
E
L
G
Y
-
I
P
V
L
T
K
V
-
L
D
D
P
-
E
I
K
N
-----
D
P
V
I
Y
G
F
G
Q
A
-
V
---
Q
---
H
-
A
Y
L
M
P
K
S
P
K
M
--
S
A
V
W
G
G
V
D
G
-
A
I
N
E
I
L
Q
----
D
PQ
N
-
A
D
I
E
G
I
L
K
K
Y
Q
Q
E
I
L
N
N
M
Q
----
123
HHSearch
49.24
13%
-30
- C1 -
2Z8F
6
?
A:
[12-404]
---------------------------------
D
G
G
V
V
N
I
T
Y
M
H
R
L
--
P
D
-
S
E
G
M
T
L
V
N
D
I
V
A
K
W
N
K
----
Q
H
P
D
I
Q
V
K
A
T
K
F
D
G
K
A
-
S
D
M
I
K
K
L
E
T
D
V
K
S
-
G
-
E
A
P
D
L
A
Q
-
V
G
Y
-
A
E
L
P
E
V
F
T
K
G
L
-
L
Q
D
V
T
Q
Y
A
E
----
Q
Y
--
K
N
D
F
A
S
G
----
P
Y
S
L
V
-
Q
V
-
G
G
K
A
Y
G
L
P
Q
D
-
T
G
P
L
V
Y
F
Y
N
K
A
E
F
E
K
L
G
I
T
E
I
P
Q
T
A
D
E
F
I
A
A
A
K
T
A
A
A
A
G
K
------
Y
I
M
S
Y
Q
P
D
E
A
G
--
N
M
---
I
S
G
L
A
-
G
A
S
G
---
G
W
----
Y
K
-
V
K--
G
-------
D
----
S
W
V
---
V
N
T
E
T
D
G
S
K
A
T
A
D
F
Y
Q
Q
L
-----------------
L
D
A
---
K
-
A
A
T
T
-----
N
PRWD-----
P
S
----------
F
D
A
----
S
I
K
D
G
S
L
I
G
T
V
A
----
A
A
W
E
A
P
L
F
M
T
S
S
G
-
G
T
-
G
S
G
E
W
Q
V
A
Q
L
G
D
W
F
G
N
A
---
G
K
T
G
P
D
G
G
S
A
V
A
V
L
K
N
S
--
K
H
--
P
K
E
A
M
E
F
L
D
-
W
F
N
T
Q
V
-
P
D
---
L
V
S
Q
G
L
-
V
P
A
A
T
T
E
D
A
E
T
P
S
E
W
S
T
F
F
-
G
G
Q
D
I
M
K
E
F
K
T
A
-
N
---
N
---
N
-
M
G
D
F
T
Y
M
P
G
F
--
S
A
V
A
A
K
M
N
E
-
T
A
A
K
A
T
D
----
G
--
S
-
G
K
V
A
D
I
F
S
D
A
Q
T
T
S
V
D
T
L
K
----
135
HHSearch
48.48
15%
-29
- C1 -
2XD3
3
MALX_STRPN
A:
[36-410]
--------------------------------------
E
L
T
V
Y
V
D
E
--
G
----
Y
K
S
Y
I
E
E
V
A
K
A
Y
E
K
----
E
-
A
G
V
K
V
T
L
K
T
G
D
A
---
L
G
G
L
D
K
L
S
L
D
N
Q
N
-
G
-
N
V
P
D
V
M
M
-
A
P
Y
-
D
R
V
G
S
L
G
S
D
G
Q
-
L
S
E
V
K
L
S
D
G
A
---
K
--
T
-
D
D
T
T
K
S
----
L
V
--
T
-
A
A
-
N
G
K
V
Y
G
A
P
A
V
-
I
E
S
L
V
M
Y
Y
N
K
D
L
V
K
D
-----
A
P
K
T
F
A
D
L
E
N
L
A
K
D
S
K
Y
A
F
A
G
E
DG
K
T
T
A
F
L
--
A
--
D
W
-
T
N
F
Y
Y
T
-
Y
G
L
L
A
G
-
N
G
---
A
Y
----
V
F
-
G
Q--
N
-------
G
KDAK
D
-----
I
G
L
A
N
D
G
S
I
V
G
I
N
Y
A
K
S
W
-----------------
Y
E
K
WPK
G
-
M
Q
D
T
EG
A
G
-
N
---------
L
-----------
I
Q
T
----
Q
F
Q
E
G
K
T
A
A
I
I
D
----
G
P
W
K
A
Q
A
F
K
D
A
-----
K
--
V
N
Y
G
V
A
T
I
P
T
L
P
N
G
K
---
E
Y
A
A
F
G
G
G
K
A
W
V
I
P
Q
A
V
--
K
N
--
L
E
A
S
Q
K
F
V
D
-
F
L
V
A
T
E
-
Q
Q
K
V
L
Y
D
K
T
N
E
-
I
P
A
N
T
E
A
-
R
S
Y
A
-
E
G
K
-----
N
D
E
L
T
T
A
V
I
K
Q
-
F
---
K
---
N
-
T
Q
P
L
P
N
I
S
Q
M
--
S
A
V
W
D
P
A
K
N
-
M
L
F
D
A
V
S
----
G
--
Q
-
K
D
A
K
T
A
A
N
D
A
V
T
L
I
K
E
T
L
-----
126
HHSearch
48.47
14%
-48
- C- -
1URS
1
?
A:
[30-396]
-------------------------------------
Q
T
I
T
V
W
S
W
Q
--
T
G
-
P
-
E
L
Q
D
V
K
Q
I
A
A
Q
W
A
K
----
A
H
G
-
D
K
V
I
V
V
D
Q
S
S
-
N
-
P
K
G
F
Q
F
Y
A
T
A
A
R
T
-
G
-
K
G
P
D
V
V
F
G
M
P
H
-
D
N
N
G
V
F
A
E
E
G
L
-
M
A
P
V
P
S
G
V
L
N
-------
T
G
L
Y
A
P
N
----
T
I
D
A
I
-
K
V
-
N
G
T
M
Y
S
V
P
V
S
-
V
Q
V
A
A
I
Y
Y
N
K
K
L
V
P
Q
-----
P
P
Q
T
W
A
E
F
V
K
D
A
N
A
H
G
F
----------
M
Y
D
--
Q
A
-
N
L
---
Y
F
D
Y
--
A
I
I
G
G
Y
G
G
---
Y
V
----
F
K
-
D
N--
N
GTLDP--
N
----
N
-----
I
G
L
D
T
P
G
A
V
Q
A
Y
T
L
M
R
D
M
-----------------
V
S
K
---
Y
-
H
W
M
T
PSTN
G
S
---------
I
-----------
A
K
A
----
E
F
L
A
G
K
I
G
M
Y
V
S
----
G
P
W
D
T
A
D
I
E
K
A
-----
K
--
I
D
F
G
V
T
P
W
P
T
L
P
N
G
K
---
H
A
T
P
F
L
G
V
I
T
A
F
V
N
K
E
S
--
K
T
--
Q
A
A
D
W
S
L
V
Q
-
A
L
T
S
A
Q
-
A
Q
Q
M
Y
F
R
D
S
Q
Q
-
I
P
A
L
L
S
V
-
Q
R
S
S
-
A
V
Q
-----
S
S
P
T
F
K
A
F
V
E
Q
-
L
---
R
---
Y
-
A
V
P
M
P
N
I
P
Q
M
--
Q
A
V
W
Q
A
M
-
S
-
I
L
Q
N
I
I
A
----
G
--
K
-
V
S
P
E
Q
G
A
K
D
F
V
Q
N
I
Q
K
G
------
130
HHSearch
46.99
15%
-50
- C1 -
2HEU
2
?
A:
[16-338]
----------------------------------
S
S
T
V
T
I
E
Y
F
N
Q
K
--
K
E
---
M
T
K
T
L
E
E
I
T
R
D
F
E
K
----
E
N
P
K
I
-
V
K
V
V
N
V
P
N
-----
A
G
E
V
L
K
T
R
V
L
A
-
G
-
D
V
P
D
V
V
N
I
Y
P
Q
S
I
E
L
Q
E
W
A
K
A
G
V
-
F
E
D
L
S
N
K
D
Y
L
K
--
R
V
------
K
N
G
----
Y
A
E
K
Y
-
A
V
-
N
E
K
V
Y
N
V
P
F
T
-
A
N
A
Y
G
I
Y
Y
N
K
D
K
F
E
E
L
G
L
K
-
V
P
E
T
W
D
E
F
E
Q
L
V
K
D
I
V
A
K
G
Q
T
----
P
F
G
I
A
--
G
A
D
A
W
T
L
N
G
Y
N
Q
-
L
A
F
A
T
A
T
G
G
---
G
K
E
A
N
Q
Y
L
-
R
YSQ
P
-------
N
----
A
-----
I
K
L
S
D
P
I
M
K
D
D
I
K
V
M
D
I
L
-----------------
R
I
N
---
G
-
S
K
Q
K
-----
N
WEGAG
Y
T
--
D
-----------
V
I
G
----
A
F
A
R
G
D
V
L
M
T
P
N
----
G
S
W
A
I
T
A
I
N
E
Q
K
P
---
N
--
F
K
I
G
T
F
M
I
P
G
K
E
K
G
Q
---
S
L
T
V
G
A
G
D
L
A
W
S
I
S
A
T
T
--
K
H
--
P
K
E
A
N
A
F
V
E
-
Y
M
T
R
P
E
-
V
M
Q
K
Y
Y
D
V
D
G
S
-
P
T
A
I
E
G
V
-
K
-----------------------------------------------------------------------------------------------
108
Fugue
46.70
12%
-29
- C1 -
2UVH
2
?
A:
[5-408]
----------------------------------
E
V
N
L
R
M
S
W
W
G
----
G
N
-
G
-
R
H
Q
V
T
L
K
A
L
E
E
F
H
K
----
Q
H
P
N
I
N
V
K
A
E
Y
T
G
--
W
-
D
G
H
L
S
R
L
T
T
Q
I
A
G
-
G
-
T
E
P
D
V
M
-
Q
T
N
W
-
N
W
L
P
I
F
S
K
D
G
T
-
G
F
Y
N
--
L
F
S
V
K
--
E
Q
-
L
D
L
A
Q
F
D
P
----
K
E
L
Q
Q
-
T
T
V
N
G
K
L
N
G
I
P
I
S
-
V
T
A
R
I
F
Y
F
N
D
A
T
W
A
K
A
G
L
E
-
Y
P
K
T
W
D
E
L
L
A
A
G
K
V
F
K
E
K
L
G
D
Q
--
Y
Y
P
----
V
V
L
E
H
Q
D
T
L
A
L
I
R
S
Y
M
T
Q
K
Y
N
I
P
---
T
I
----
D
E
-
A
---
N
-------
K
----
K
-----
F
A
Y
S
P
E
Q
W
V
E
F
F
T
M
Y
K
T
M
-----------------
V
D
N
---
H
-
V
M
P
S
-----
T
---------
K
-----------
Y
Y
A
SFGK
S
N
M
Y
E
M
K
P
W
I
N
G
----
E
W
A
G
T
Y
M
W
N
S
T
I
T
-
K
Y
S
D
N
L
T
K
P
A
K
L
V
L
G
P
Y
P
M
L
P
G
A
K
D
A
G
L
F
F
K
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A
Q
M
L
S
I
G
K
--
S
T
K
H
P
Q
E
S
A
M
L
I
N
-
F
L
L
N
S
-
K
E
G
V
E
A
L
G
L
E
R
G
-
V
P
L
S
A
T
A
-
V
T
Q
L
-
R
A
S
G
V
I
-
K
D
E
D
P
S
V
A
G
L
N
M
-
A
---
L
E
LP
H
-
K
M
T
T
S
P
Y
F
D
D
--
P
Q
I
V
S
L
F
-
G
D
A
I
Q
Y
I
D
Y
----
G
--
Q
-
K
T
V
Q
E
T
A
E
Y
F
N
K
Q
G
D
R
I
L
K
R
A
M
R