@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0866: (2016-03-19 )
LTKFSEFGLDEKIVKSVNRMGFEEATPIQEKTIPLGLEGKDLIGQAQTGTGKTAAFGLPMIHKIDQKSNNVQALIIAPTRELAIQVSEELYKLSYDKHVRVLAVYGGSDISRQIRSLKKNPQIVVGTPGRILDHINRRTLKLDHVETLVLDEADEMLNMGFIDDIETILKEVPAERQTLLFSATMPDPIRRIGERFMHSPELIRIKAKEMTALLIEQFFVKVHEKEKFDVLSRLLDVQAPELAIVFGRTKRRVDELSRALDMRGYVAEGIHGDLTQAKRMSVLRKFKEGKIDVLVATDVAARGLDISGVTHVYNYDIPQDPESYVHRIGRTGRAGKEGMAITFVQPREMGYLRIVEETTKKRMQPLQAPTWDEAFAGQLRVATEKIQEAITEENLADYKTFANELLEKYDATDIAAAMLKMLAKEPDKTPVHITEERPLPSRGGGGYKGKNGKGGKGGGYRGGSGKGGSYRDRNNSGKGRRSGGGSGGGSGSGGGGNRDRRGGGEQRSGGNKGNYSQKSK
Atome Classification :
(65 SA)
.........10........20........30...--...--.--.--40.........50........-60--.-...---.-----..------------------.-----.70--.---------.----.----------------......80....---....90..-----.-..-----...---100.......110..--..-...-120........130----....-..-.-.--140-.......150.....---..-160.......---.170-.----.----..--.----...180.......190.......200......-.-----------210......----.220-...-.-...230....-...240........250.......260--........270.......280.......290.......300.......310......------.------320.......330.......340......-.350.......360.......370.........380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LT
K
F
S
EFGL
D
E
K
I
V
K
S
V
N
RMGFEEATPIQEKTIP--LGL--E--G--
K
-
D
LIGQAQTGTGKTAAFG
L
P
-
M
---
I
-
H
K
I---D-----QK------------------S-----NN---
V
---------
Q
----
A
----------------
L
I
IAPT
R
E
L
A
I
Q
---
V
S
E
E
L
Y
K
L-----S-YD-----
K
H
V
---
R
V
L
A
V
YGG
S
D
I
S
R
Q
I
--
R
S
-LKK-N-P
Q
I
V
VGT
P
G
R
I
-----
L
D
H
I-NR-R-
T
--
L
K
L
-
D
H
V
E
T
L
V
LD
E
A
D
E
M
L
---NM-G-
F
I
D
D
I
E
T
I
---
L
K
E--V----P----AE--R----
Q
T
L
L
F
SATM
P
D
P
I
R
R
I
G
E
R
FMHSP
E
L
I
R
I
K
A
K
-
E
-----------
M
T
A
L
L
I
E
Q
F
----
F
V
K
V-H
E
K
-
E
-
K
F
D
V
L
S
R
L
L
D-VQAP
E
-
L
A
I
V
FGR
T
K
R
R
V
D
E
L
S
R
A
L
D
---
M
R
G
Y
V
A
EGIH
G
D
L
T
Q
A
K
R
M
S
V
L
R
K
F
KEG
K
I
D
V
L
V
AT
D
V
AARGLDISG
V
T
H
V
Y
NYDIP------Q------D
P
E
S
Y
V
H
R
IGRTGRAGKE
G
M
A
I
T
F
VQPRE-MG
Y
L
R
I
V
E
E
T
T
K
KRMQPLQAPT--W
D
E
A
F
A
G
Q
L
R
V
A
T
E
K
I
Q
E
A
I
T
E
E
N
L
A
D
Y
K
T
F
A
N
E
L
L
E
KYD
A
T
D
I
A
A
A
M
L
K
M
L
AKEPDKT
P
V
H
I
TEERPLPSRGGGGYKGKNGKGGKGGGYRGGSGKGGSYRDRNNSGKGRRSGGGSGGGSGSGGGGNRDRRGGGEQRSGGNKGNYSQKSK
110
HHSearch
90.91
47%
-101
- C4 -
1HV8
5
H669_METJA
A:
[6-362]
-
M
N
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
--
L
F
L
--
N
--
D
E-
Y
-
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
-
L
---
I
-
E
L
V
---
N
-----
E
-------------------
N
-----
N
G
---
I
---------
E
----
A
----------------
I
I
L
T
P
T
R
E
L
A
I
Q
---
V
A
D
E
I
E
S
L
-----
K
-
G
N
-----
K
N
L
---
K
I
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
---
K
-
A
L
K
-
N
-
A
N
I
V
V
G
T
P
G
R
I
-----
L
D
H
I
-
N
R
-
G
-
T
--
L
N
L
-
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
---
N
M
-
G
-
F
I
K
D
V
E
K
I
---
L
N
A
--
C
----
N
----
K
D
--
K
----
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
K
A
K
----------------
I
N
A
N
I
E
Q
S
----
Y
V
E
V
-
N
E
N
-
E
-
R
F
E
A
L
C
R
L
L
K
--
N
K
E
F
-
Y
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
---
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
------
Q
------
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
E
-
Y
K
K
L
R
Y
I
E
R
A
M
K
L
K
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.82
46%
-110
- C4 -
1HV8
5
H669_METJA
A:
[8-354]
---
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
--
L
F
L
--
N
--
D
--
E
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
-
L
---
I
-
E
L
V
---
N
-----
E
-------------------
N
-----
N
G
---
I
---------
E
----
A
----------------
I
I
L
T
P
T
R
E
L
A
I
Q
---
V
A
D
E
I
E
S
L
-----
K
-
G
N
-----
K
N
L
---
K
I
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
--
K
A
-
L
K
--
N
-
A
N
I
V
V
G
T
P
G
R
I
-----
L
D
H
I
-
N
R
-
G
-
T
--
L
N
L
-
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
---
N
M
-
G
-
F
I
K
D
V
E
K
I
---
L
N
A
--
C
----
N
----
K
D
--
K
----
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
K
A
K
I
N
-
A
-----------
N
----
I
E
Q
S
----
Y
V
E
V
-
N
E
N
-
E
-
R
F
E
A
L
C
R
L
L
K
--
N
K
E
F
-
Y
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
---
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
------
Q
------
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
E
-
Y
K
K
L
R
Y
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
90.44
44%
-96
- C4 -
4KBG
4
?
B:
[2-362]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
APS
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
D
-
E
-------------
P
V
T
Y
E
E
E
----
A
V
P
A
-
P
V
R
-
G
-
R
L
E
V
L
S
D
L
L
Y
-
V
A
S
P
D
-
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
---
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
89.27
44%
-102
- C4 -
4KBF
1
?
B:
[2-362]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
APS
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
D
-
E
-------------
P
V
T
Y
E
E
E
----
A
V
P
A
-
P
V
R
-
G
-
R
L
E
V
L
S
D
L
L
Y
-
V
A
S
P
D
-
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
---
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
89.25
44%
-92
- C4 -
4KBF
3
?
A:
[2-362]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
APS
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
D
-
E
-------------
P
V
T
Y
E
E
E
----
A
V
P
A
-
P
V
R
-
G
-
R
L
E
V
L
S
D
L
L
Y
-
V
A
S
P
D
-
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
---
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
87.36
39%
-89
- C4 -
4PXA
6
DDX3X_HUMAN
A:
[64-460]
I
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
-
I
---
L
-
S
Q
I
Y
S
-
D
-----
G
P
------------------
G
-----
E
A
---
L
---------
R
----
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
-----
S
-
Y
R
-----
S
R
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
--
R
D
-
L
E
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
-
K
--
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
V
M
-
G
-
F
E
P
Q
I
R
R
I
---
V
E
Q
DT
M
----
P
----
P
K
GV
R
----
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
-
G
-----------
S
T
S
E
N
I
T
Q
K
----
V
V
W
V
-
E
E
S
-
D
-
K
R
S
F
L
L
D
L
L
N
-
A
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
N
-
I
N
I
T
K
D
L
L
D
L
L
V
E
A
K
Q
--
E
V
P
S
--
W
L
E
N
M
A
------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
86.88
43%
-105
- C4 -
2I4I
1
DDX3X_HUMAN
A:
[16-388]
--
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
-
I
---
L
-
S
Q
I
---
Y
-----
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
-----
Q
Y
---
P
---------
I
----
S
----------------
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
-----
S
-
Y
R
-----
S
R
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
--
R
D
-
L
E
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
-
K
--
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
R
I
---
V
E
Q
--
D
TMPP
K
----
G
V
--
R
----
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
----------------
T
S
E
N
I
T
Q
K
----
V
V
W
V
-
E
E
S
-
D
-
K
R
S
F
L
L
D
L
L
N
A
T
G
K
D
S
-
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
-
I
N
I
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
86.83
39%
-102
- C4 -
2I4I
1
DDX3X_HUMAN
A:
[14-410]
I
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
-
I
---
L
-
S
Q
I
Y
S
-
D
-----
G
P
------------------
G
-----
E
A
---
L
---------
R
----
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
-----
S
-
Y
R
-----
S
R
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
--
R
D
-
L
E
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
-
K
--
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
R
I
---
V
E
Q
DT
M
----
P
----
P
K
GV
R
----
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
----------------
T
S
E
N
I
T
Q
K
----
V
V
W
V
-
E
E
S
-
D
-
K
R
S
F
L
L
D
L
L
N
-
A
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
-
I
N
I
T
K
D
L
L
D
L
L
V
E
A
K
Q
--
E
V
P
S
--
W
L
E
N
M
A
------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
86.62
35%
-102
- C4 -
4CT4
2
DDX6_HUMAN
D:
[6-369]
--
E
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
--
I
A
L
--
S
--
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
-
L
---
L
-
E
R
L
---
D
-----
L
K
------------------
K
-----
D
N
---
I
---------
Q
----
A
----------------
M
V
I
V
P
T
R
E
L
A
L
Q
---
V
S
Q
I
C
I
Q
V
-----
S
--------
K
H
M
G
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
--
M
R
-
L
D
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
-----
L
D
L
I
-
K
K
-
G
-
V
--
A
K
V
-
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
---
S
Q
-
D
-
F
V
Q
I
M
E
D
I
---
I
L
T
--
L
----
P
----
K
N
--
R
----
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
-
M
E
-
E
-----------
L
T
L
K
G
V
T
Q
Y
----
Y
A
Y
V
-
T
E
R
-
Q
-
K
V
H
C
L
N
T
L
F
S
-
R
L
Q
I
N
-
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
---
Q
L
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
----
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
-
R
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
P
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
86.12
35%
-104
- C4 -
4CT4
3
DDX6_HUMAN
B:
[6-369]
--
E
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
--
I
A
L
--
S
--
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
-
L
---
L
-
E
R
L
---
D
-----
L
K
------------------
K
-----
D
N
---
I
---------
Q
----
A
----------------
M
V
I
V
P
T
R
E
L
A
L
Q
---
V
S
Q
I
C
I
Q
V
-----
S
--------
K
H
M
GGA
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
--
M
R
-
L
D
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
-----
L
D
L
I
-
K
K
-
G
-
V
--
A
K
V
-
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
---
S
Q
-
D
-
F
V
Q
I
M
E
D
I
---
I
L
T
--
L
----
P
----
K
N
--
R
----
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
-
M
E
-
E
-----------
L
T
L
K
G
V
T
Q
Y
----
Y
A
Y
V
-
T
E
R
-
Q
-
K
V
H
C
L
N
T
L
F
S
-
R
L
Q
I
N
-
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
---
Q
L
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
-
R
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
P
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.85
41%
-101
- C4 -
2J0S
3
IF4A3_HUMAN
A:
[39-393]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
-
V
---
L
-
Q
C
L
---
D
-----
I
Q
------------------
V
-----
R
E
---
T
---------
Q
----
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
-----
G
-
D
Y
-----
M
N
V
---
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
--
R
K
-
L
D
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
-----
F
D
M
I
-
R
R
-
R
-
S
--
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
D
V
---
Y
R
Y
--
L
----
P
----
P
A
--
T
----
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
-
E
-----------
L
T
L
E
G
I
K
Q
F
----
F
V
A
V
-
E
R
E
-
E
W
K
F
D
T
L
C
D
L
Y
D
-
T
L
T
I
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
---
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
R
I
L
R
D
I
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
85.31
40%
-85
- C4 -
2DB3
3
VASA1_DROME
A:
[56-408]
-
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
--
V
I
S
--
S
--
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
-
I
---
L
-
S
K
L
---
L
-----
E
D
------------------
P
H
E
L
E
L
G
R
---
P
---------
Q
----
V
----------------
V
I
V
S
P
T
R
E
L
A
I
Q
---
I
F
N
E
A
R
K
F
-----
A
-
F
E
-----
S
Y
L
---
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
--
E
C
-
I
T
R
-
G
-
C
H
V
V
I
A
T
P
G
R
L
-----
L
D
F
V
-
D
R
-
T
-
F
--
I
T
F
-
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
S
E
D
M
R
R
I
---
M
T
H
--
V
----
T
MR--
P
E
--
H
----
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
-
G
-----------
G
A
C
S
D
V
K
Q
T
----
I
Y
E
V
-
N
K
Y
-
A
-
K
R
S
K
L
I
E
I
L
S
--
E
Q
A
D
-
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
---
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.11
41%
-98
- C4 -
3EX7
4
IF4A3_HUMAN
C:
[40-394]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
-
V
---
L
-
Q
C
L
---
D
-----
I
Q
------------------
V
-----
R
E
---
T
---------
Q
----
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
-----
G
-
D
Y
-----
M
N
V
---
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
--
R
K
-
L
D
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
-----
F
D
M
I
-
R
R
-
R
-
S
--
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
D
V
---
Y
R
Y
--
L
----
P
----
P
A
--
T
----
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
-
E
-----------
L
T
L
E
G
I
K
Q
F
----
F
V
A
V
-
E
R
E
-
E
W
K
F
D
T
L
C
D
L
Y
D
-
T
L
T
I
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
---
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
R
I
L
R
D
I
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.05
41%
-98
- C4 -
2HYI
3
IF4A3_HUMAN
C:
[40-394]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
-
V
---
L
-
Q
C
L
---
D
-----
I
Q
------------------
V
-----
R
E
---
T
---------
Q
----
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
-----
G
-
D
Y
-----
M
N
V
---
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
--
R
K
-
L
D
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
-----
F
D
M
I
-
R
R
-
R
-
S
--
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
D
V
---
Y
R
Y
--
L
----
P
----
P
A
--
T
----
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
-
E
-----------
L
T
L
E
G
I
K
Q
F
----
F
V
A
V
-
E
R
E
-
E
W
K
F
D
T
L
C
D
L
Y
D
-
T
L
T
I
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
---
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
R
I
L
R
D
I
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.80
41%
-98
- C4 -
2HYI
3
IF4A3_HUMAN
I:
[40-394]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
-
V
---
L
-
Q
C
L
---
D
-----
I
Q
------------------
V
-----
R
E
---
T
---------
Q
----
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
-----
G
-
D
Y
-----
M
N
V
---
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
--
R
K
-
L
D
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
-----
F
D
M
I
-
R
R
-
R
-
S
--
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
D
V
---
Y
R
Y
--
L
----
P
----
P
A
--
T
----
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
-
E
-----------
L
T
L
E
G
I
K
Q
F
----
F
V
A
V
-
E
R
E
-
E
W
K
F
D
T
L
C
D
L
Y
D
-
T
L
T
I
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
---
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
R
I
L
R
D
I
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
84.68
35%
-101
- C4 -
3EWS
1
DD19B_HUMAN
A:
[64-442]
---
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
--
L
M
L
--
A
EP
P
--
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
-
M
---
L
-
S
Q
V
---
E
-----
P
A
------------------
N
-----
K
Y
---
P
---------
Q
----
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
-------
Y
P
-----
E
L
K
---
L
A
Y
A
V
R
G
----
N
K
L
E
--
R
G
-
Q
K
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
L
K
-
F
--
I
D
P
-
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A--
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
---
Q
R
M
--
L
----
P
----
R
N
--
C
----
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
-
E
-----------
E
T
L
D
T
I
K
Q
Y
----
Y
V
L
C
-
S
S
R
D
E
-
K
F
Q
A
L
C
N
L
Y
G
-
A
I
T
I
A
-
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
D
KDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
T
D
D
--
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
84.52
39%
-89
- C4 -
2DB3
3
VASA1_DROME
C:
[55-406]
I
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
--
V
I
S
--
S
--
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
-
I
---
L
-
S
K
L
---
L
-----
E
D
------------------
P
-----
H
E
---
L
ELGRP----
Q
----
V
----------------
V
I
V
S
P
T
R
E
L
A
I
Q
---
I
F
N
E
A
R
K
F
-----
A
-
F
E
-----
S
Y
L
---
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
--
E
C
-
I
T
R
-
G
-
C
H
V
V
I
A
T
P
G
R
L
-----
L
D
F
V
-
D
R
-
T
-
F
--
I
T
F
-
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
S
E
D
M
R
R
I
---
M
T
H
--
V
----
T
MR--
P
E
--
H
----
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
-
G
-----------
G
A
C
S
D
V
K
Q
T
----
I
Y
E
V
-
N
K
Y
-
A
-
K
R
S
K
L
I
E
I
L
S
-
E
Q
A
-
D
-
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
---
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.52
41%
-98
- C4 -
2XB2
4
IF4A3_HUMAN
A:
[40-394]
---
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
--
Q
I
I
--
K
--
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
-
V
---
L
-
Q
C
L
---
D
-----
I
Q
------------------
V
-----
R
E
---
T
---------
Q
----
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
---
I
Q
K
G
L
L
A
L
-----
G
-
D
Y
-----
M
N
V
---
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
--
R
K
-
L
D
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
-----
F
D
M
I
-
R
R
-
R
-
S
--
L
R
T
-
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
---
N
K
-
G
-
F
K
E
Q
I
Y
D
V
---
Y
R
Y
--
L
----
P
----
P
A
--
T
----
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
-
E
-----------
L
T
L
E
G
I
K
Q
F
----
F
V
A
V
-
E
R
E
-
E
W
K
F
D
T
L
C
D
L
Y
D
-
T
L
T
I
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
---
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
R
I
L
R
D
I
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
84.49
39%
-87
- C4 -
2DB3
3
VASA1_DROME
A:
[55-406]
I
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
--
V
I
S
--
S
--
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
-
I
---
L
-
S
K
L
---
L
-----
E
D
------------------
P
-----
H
E
---
L
E
L
GRP----
Q
----
V
----------------
V
I
V
S
P
T
R
E
L
A
I
Q
---
I
F
N
E
A
R
K
F
-----
A
-
F
E
-----
S
Y
L
---
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
--
E
C
-
I
T
R
-
G
-
C
H
V
V
I
A
T
P
G
R
L
-----
L
D
F
V
-
D
R
-
T
-
F
--
I
T
F
-
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
S
E
D
M
R
R
I
---
M
T
H
--
V
----
T
MR--
P
E
--
H
----
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
-
G
-----------
G
A
C
S
D
V
K
Q
T
----
I
Y
E
V
-
N
K
Y
-
A
-
K
R
S
K
L
I
E
I
L
S
-
E
Q
A
-
D
-
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
---
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
84.33
39%
-88
- C4 -
2DB3
3
VASA1_DROME
D:
[55-406]
I
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
--
V
I
S
--
S
--
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
-
I
---
L
-
S
K
L
---
L
-----
E
D
------------------
P
-----
H
E
---
L
ELGRP----
Q
----
V
----------------
V
I
V
S
P
T
R
E
L
A
I
Q
---
I
F
N
E
A
R
K
F
-----
A
-
F
E
-----
S
Y
L
---
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
--
E
C
-
I
T
R
-
G
-
C
H
V
V
I
A
T
P
G
R
L
-----
L
D
F
V
-
D
R
-
T
-
F
--
I
T
F
-
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
S
E
D
M
R
R
I
---
M
T
H
--
V
----
T
MR--
P
E
--
H
----
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
-
G
-----------
G
A
C
S
D
V
K
Q
T
----
I
Y
E
V
-
N
K
Y
-
A
-
K
R
S
K
L
I
E
I
L
S
-
E
Q
A
-
D
-
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
---
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
83.47
39%
-115
- C4 -
2VSO
1
IF4A_YEAST
B:
[23-386]
--
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
--
P
I
I
--
E
--
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
-
A
---
L
-
Q
R
I
---
D
-----
T
S
------------------
V
-----
K
A
---
P
---------
Q
----
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
---
I
Q
K
V
V
M
A
L
-----
A
-
F
H
-----
M
D
I
---
K
V
H
A
C
I
G
-------------
L
R
--
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
-
R
-
R
--
F
R
T
-
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
---
F
T
L
--
L
----
P
----
P
T
--
T
----
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
-
E
-----------
L
T
L
E
G
I
K
Q
F
----
Y
V
N
V
-
E
E
E
-
E
Y
K
Y
E
C
L
T
D
L
Y
D
-
S
I
S
V
T
-
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.35
39%
-113
- C4 -
2VSX
1
IF4A_YEAST
B:
[23-386]
--
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
--
P
I
I
--
E
--
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
-
A
---
L
-
Q
R
I
---
D
-----
T
S
------------------
V
-----
K
A
---
P
---------
Q
----
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
---
I
Q
K
V
V
M
A
L
-----
A
-
F
H
-----
M
D
I
---
K
V
H
A
C
I
G
-------------
L
R
--
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
-
R
-
R
--
F
R
T
-
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
---
F
T
L
--
L
----
P
----
P
T
--
T
----
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
-
E
-----------
L
T
L
E
G
I
K
Q
F
----
Y
V
N
V
-
E
E
E
-
E
Y
K
Y
E
C
L
T
D
L
Y
D
-
S
I
S
V
T
-
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
83.31
39%
-113
- C4 -
2VSO
1
IF4A_YEAST
A:
[23-386]
--
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
--
P
I
I
--
E
--
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
-
A
---
L
-
Q
R
I
---
D
-----
T
S
------------------
V
-----
K
A
---
P
---------
Q
----
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
---
I
Q
K
V
V
M
A
L
-----
A
-
F
H
-----
M
D
I
---
K
V
H
A
C
I
G
-------------
L
R
--
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
-
R
-
R
--
F
R
T
-
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
---
F
T
L
--
L
----
P
----
P
T
--
T
----
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
-
E
-----------
L
T
L
E
G
I
K
Q
F
----
Y
V
N
V
-
E
E
E
-
E
Y
K
Y
E
C
L
T
D
L
Y
D
-
S
I
S
V
T
-
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
82.94
39%
-113
- C4 -
2VSX
1
IF4A_YEAST
A:
[23-386]
--
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
--
P
I
I
--
E
--
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
-
A
---
L
-
Q
R
I
---
D
-----
T
S
------------------
V
-----
K
A
---
P
---------
Q
----
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
---
I
Q
K
V
V
M
A
L
-----
A
-
F
H
-----
M
D
I
---
K
V
H
A
C
I
G
-------------
L
R
--
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
-
R
-
R
--
F
R
T
-
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
---
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
---
F
T
L
--
L
----
P
----
P
T
--
T
----
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
-
E
-----------
L
T
L
E
G
I
K
Q
F
----
Y
V
N
V
-
E
E
E
-
E
Y
K
Y
E
C
L
T
D
L
Y
D
-
S
I
S
V
T
-
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
82.42
35%
-95
- C4 -
3FHT
6
DD19B_HUMAN
B:
[27-400]
---
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
--
L
M
L
--
A
EP
P
--
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
-
M
---
L
-
S
Q
V
---
E
-----
P
A
------------------
N
-----
K
Y
---
P
---------
Q
----
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
-------
Y
P
-----
E
L
K
---
L
A
Y
A
V
R
G
----
N
---------
K
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
L
K
-
F
--
I
D
P
-
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A--
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
---
Q
R
M
--
L
----
P
----
R
N
--
C
----
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
-
E
-----------
E
T
L
D
T
I
K
Q
Y
----
Y
V
L
C
-
S
S
R
D
E
-
K
F
Q
A
L
C
N
L
Y
G
-
A
I
T
I
A
-
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
82.38
35%
-92
- C4 -
3G0H
4
DD19B_HUMAN
A:
[43-416]
---
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
--
L
M
L
--
A
EP
P
--
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
-
M
---
L
-
S
Q
V
---
E
-----
P
A
------------------
N
-----
K
Y
---
P
---------
Q
----
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
-------
Y
P
-----
E
L
K
---
L
A
Y
A
V
R
G
----
N
K
L
E
--
R
G
-
Q
K
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
L
K
-
F
--
I
D
P
-
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A--
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
---
Q
R
M
--
L
----
P
----
R
N
--
C
----
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
-
E
-----------
E
T
L
D
T
I
K
Q
Y
----
Y
V
L
C
-
S
S
R
D
E
-
K
F
Q
A
L
C
N
L
Y
G
-
A
I
T
I
A
-
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
82.32
35%
-94
- C4 -
3FHT
4
DD19B_HUMAN
A:
[27-399]
---
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
--
L
M
L
--
A
EP
P
--
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
-
M
---
L
-
S
Q
V
---
E
-----
P
A
------------------
N
-----
K
Y
---
P
---------
Q
----
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
-------
Y
P
-----
E
L
K
---
L
A
Y
A
V
R
G
----
N
K
L
E
--
R
G
-
Q
K
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
L
K
-
F
--
I
D
P
-
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A--
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
---
Q
R
M
--
L
----
P
----
R
N
--
C
----
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
-
E
-----------
E
T
L
D
T
I
K
Q
Y
----
Y
V
L
C
-
S
S
R
D
E
-
K
F
Q
A
L
C
N
L
Y
G
-
A
I
T
I
A
-
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
81.98
34%
-93
- C4 -
3PEW
10
DBP5_YEAST
A:
[7-385]
---
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
--
L
L
L
--
H
--
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
-
M
---
L
-
T
R
V
---
N
-----
P
E
------------------
D
-----
A
S
---
P
---------
Q
----
A
----------------
I
C
L
A
P
S
R
E
L
A
R
Q
---
T
L
E
V
V
Q
E
M
G
----
K
-
F
T
-----
K
I
T
---
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
---------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
-
K
-
L
--
M
Q
L
-
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
---
K
R
F
--
L
----
P
----
K
D
--
T
----
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
-
E
-----------
V
N
V
D
A
I
K
Q
L
----
Y
M
D
C
K
N
E
A
-
D
-
K
F
D
V
L
T
E
L
Y
G
-
V
M
T
I
G
-
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
DD
W
D
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
81.87
37%
-90
- C4 -
4D25
4
?
A:
[49-404]
I
E
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
--
I
I
M
--
S
--
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
-
I
---
I
-
N
M
L
---
L
-----
Q
D
------------------
P
-----
K
D
---
L
I
S
E
NG
C
A
Q
P
Q
----
V
----------------
I
I
V
S
P
T
R
E
L
T
L
Q
---
I
F
N
E
A
R
K
F
-----
S
-
Y
G
-----
S
V
L
---
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
--
D
N
-
I
A
R
-
G
-
C
H
I
L
V
A
T
P
G
R
L
-----
H
D
F
V
-
E
R
-
N
-
R
--
V
S
F
-
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
---
D
M
-
G
-
F
M
P
S
I
E
K
M
---
M
L
H
--
P
----
T
MVET
T
K
--
R
----
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
-
G
-----------
G
A
S
T
D
V
E
Q
I
----
F
I
E
V
-
T
K
Y
-
E
-
K
R
N
S
L
K
Q
L
I
E
-
E
N
D
G
K
-
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
---
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
81.83
34%
-92
- C4 -
3PEY
11
DBP5_YEAST
A:
[7-385]
---
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
--
L
L
L
--
H
--
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
-
M
---
L
-
T
R
V
---
N
-----
P
E
------------------
D
-----
A
S
---
P
---------
Q
----
A
----------------
I
C
L
A
P
S
R
E
L
A
R
Q
---
T
L
E
V
V
Q
E
M
G
----
K
-
F
T
-----
K
I
T
---
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
---------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
-
K
-
L
--
M
Q
L
-
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
---
K
R
F
--
L
----
P
----
K
D
--
T
----
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
-
E
-----------
V
N
V
D
A
I
K
Q
L
----
Y
M
D
C
K
N
E
A
-
D
-
K
F
D
V
L
T
E
L
Y
G
-
L
M
T
I
G
-
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
DD
W
D
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
81.24
37%
-88
- C4 -
4D26
4
?
A:
[49-404]
I
E
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
--
I
I
M
--
S
--
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
-
I
---
I
-
N
M
L
---
L
-----
Q
D
------------------
P
-----
K
D
---
L
I
S
E
NG
C
A
Q
P
Q
----
V
----------------
I
I
V
S
P
T
R
E
L
T
L
Q
---
I
F
N
E
A
R
K
F
-----
S
-
Y
G
-----
S
V
L
---
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
--
D
N
-
I
A
R
-
G
-
C
H
I
L
V
A
T
P
G
R
L
-----
H
D
F
V
-
E
R
-
N
-
R
--
V
S
F
-
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
---
D
M
-
G
-
F
M
P
S
I
E
K
M
---
M
L
H
--
P
----
T
MVET
T
K
--
R
----
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
-
G
-----------
G
A
S
T
D
V
E
Q
I
----
F
I
E
V
-
T
K
Y
-
E
-
K
R
N
S
L
K
Q
L
I
E
-
E
N
D
G
K
-
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
---
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
80.96
34%
-94
- C4 -
3RRN
2
DBP5_YEAST
A:
[7-385]
---
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
--
L
L
L
--
H
--
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
-
M
---
L
-
T
R
V
---
N
-----
P
E
------------------
D
-----
A
S
---
P
---------
Q
----
A
----------------
I
C
L
A
P
S
R
E
L
A
R
Q
---
T
L
E
V
V
Q
E
M
G
----
K
-
F
T
-----
K
I
T
---
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
---------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
-
K
-
L
--
M
Q
L
-
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
---
K
R
F
--
L
----
P
----
K
D
--
T
----
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
------------------
D
A
I
K
Q
L
----
Y
M
D
C
K
N
E
A
-
D
-
K
F
D
V
L
T
E
L
Y
G
-
V
M
T
I
G
-
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
DD
W
D
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
78.86
35%
-106
- C4 -
1XTI
4
DX39B_HUMAN
A:
[9-358]
--
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
--
Q
A
I
--
L
--
G
--
M
-
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
-
T
---
L
-
Q
Q
L
---
E
-----
P
V
------------------
T
-----
G
Q
---
V
---------
S
----
V
----------------
L
V
M
C
H
T
R
E
L
A
F
Q
---
I
S
K
E
Y
E
R
F
-----
S
-
K
Y
M----
P
N
V
---
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
--
E
V
L
K
K
N
-
C
-
P
H
I
V
V
G
T
P
G
R
I
-----
L
A
L
A
-
R
N
-
K
-
S
--
L
N
L
-
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
---
E
Q
L
D
-
M
R
R
D
V
Q
E
I
---
F
R
M
--
T
----
P
----
H
E
--
K
----
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
E
T
K
-----------
L
T
L
H
G
L
Q
Q
Y
----
Y
V
K
L
-
K
D
N
-
E
-
K
N
R
K
L
F
D
L
L
D
-
V
L
E
F
N
-
Q
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
---
E
Q
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
------
E
------
D
S
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
S
D
E
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
78.33
34%
-95
- C4 -
3RRM
1
DBP5_YEAST
A:
[11-385]
-------
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
--
L
L
L
--
H
--
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
-
M
---
L
-
T
R
V
---
N
-----
P
E
------------------
D
-----
A
S
---
P
---------
Q
----
A
----------------
I
C
L
A
P
S
R
E
L
A
R
Q
---
T
L
E
V
V
Q
E
M
G
----
K
-
F
T
-----
K
I
T
---
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
---------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
-
K
-
L
--
M
Q
L
-
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
---
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
---
K
R
F
--
L
----
P
----
K
D
--
T
----
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
----------------
V
N
V
D
A
I
K
Q
L
----
Y
M
D
C
K
N
E
A
-
D
-
K
F
D
V
L
T
E
L
Y
G
-
V
M
T
I
G
-
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
------
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
DD
W
D
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
77.80
34%
-87
- C4 -
3SQX
3
MS116_YEAST
A:
[28-408]
--------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
-
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
-
I
---
F
Q
H
L
I
---
N
-----
T
K
------------------
F
-----
D
S
QYM
V
---------
K
----
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
---
I
E
A
E
V
K
K
I
-------
H
D
M
NYGL
K
K
Y
---
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
--
N
K
-
M
N
K
L
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
-
S
--
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
L
N
E
--
K
----
N
----
S
K
--
S
ADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
-
D
KNEPEAHERID
Q
S
V
V
I
S
E
K
F
A
N
S
I
F
A
A
V
-
E
H
I
-
K
-
K
-----
Q
I
K
E
-
R
D
S
N
Y
-
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
P
F
V
R
E
L
E
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
77.67
34%
-87
- C4 -
3SQW
3
MS116_YEAST
A:
[28-408]
--------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
-
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
-
I
---
F
Q
H
L
I
---
N
-----
T
K
------------------
F
-----
D
S
QYM
V
---------
K
----
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
---
I
E
A
E
V
K
K
I
-------
H
D
M
NYGL
K
K
Y
---
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
--
N
K
-
M
N
K
L
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
-
S
--
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
L
N
E
--
K
----
N
----
S
K
--
S
ADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
-
D
KNEPEAHERID
Q
S
V
V
I
S
E
K
F
A
N
S
I
F
A
A
V
-
E
H
I
-
K
-
K
-----
Q
I
K
E
-
R
D
S
N
Y
-
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
P
F
V
R
E
L
E
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.64
36%
-102
- C4 -
4BRW
2
DHH1_YEAST
A:
[3-355]
---
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
--
V
A
I
--
T
--
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
-
T
---
L
-
E
K
V
---
K
-----
P
K
------------------
L
-----
N
K
---
I
---------
Q
----
A
----------------
L
I
M
V
P
T
R
E
L
A
L
Q
---
T
S
Q
V
V
R
T
L
-----
G
-
K
H
-----
C
G
I
---
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
--
L
R
-
L
N
E
-
T
-
V
H
I
L
V
G
T
P
G
R
V
-----
L
D
L
A
-
S
R
-
K
-
V
--
A
D
L
-
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
---
S
R
-
D
-
F
K
T
I
I
E
Q
I
---
L
S
F
--
L
----
P
----
P
T
--
H
----
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
-
M
E
-
E
-----------
L
T
L
K
G
I
T
Q
Y
----
Y
A
F
V
-
E
E
R
-
Q
-
K
L
H
C
L
N
T
L
F
S
-
K
L
Q
I
N
-
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
---
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
-
R
F
N
L
Y
K
I
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
77.59
34%
-87
- C4 -
3I62
4
MS116_YEAST
A:
[79-459]
--------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
-
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
-
I
---
F
Q
H
L
I
---
N
-----
T
K
------------------
F
-----
D
S
QYM
V
---------
K
----
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
---
I
E
A
E
V
K
K
I
-------
H
D
M
NYGL
K
K
Y
---
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
--
N
K
-
M
N
K
L
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
-
S
--
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
L
N
E
--
K
----
N
----
S
K
--
S
ADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
-
D
KNEPEAHERID
Q
S
V
V
I
S
E
K
F
A
N
S
I
F
A
A
V
-
E
H
I
-
K
-
K
-----
Q
I
K
E
-
R
D
S
N
Y
-
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
P
F
V
R
E
L
E
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
77.41
34%
-88
- C4 -
3I61
4
MS116_YEAST
A:
[79-459]
--------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
-
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
-
I
---
F
Q
H
L
I
---
N
-----
T
K
------------------
F
-----
D
S
QYM
V
---------
K
----
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
---
I
E
A
E
V
K
K
I
-------
H
D
M
NYGL
K
K
Y
---
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
--
N
K
-
M
N
K
L
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
-
S
--
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
L
N
E
--
K
----
N
----
S
K
--
S
ADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
-
D
KNEPEAHERID
Q
S
V
V
I
S
E
K
F
A
N
S
I
F
A
A
V
-
E
H
I
-
K
-
K
-----
Q
I
K
E
-
R
D
S
N
Y
-
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
P
F
V
R
E
L
E
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
77.36
34%
-88
- C4 -
3I5X
3
MS116_YEAST
A:
[79-459]
--------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
-
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
-
I
---
F
Q
H
L
I
---
N
-----
T
K
------------------
F
-----
D
S
QYM
V
---------
K
----
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
---
I
E
A
E
V
K
K
I
-------
H
D
M
NYGL
K
K
Y
---
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
--
N
K
-
M
N
K
L
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
-
S
--
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
L
N
E
--
K
----
N
----
S
K
--
S
ADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
-
D
KNEPEAHERID
Q
S
V
V
I
S
E
K
F
A
N
S
I
F
A
A
V
-
E
H
I
-
K
-
K
-----
Q
I
K
E
-
R
D
S
N
Y
-
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
P
F
V
R
E
L
E
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
76.55
34%
-87
- C4 -
3I5Y
3
MS116_YEAST
A:
[79-459]
--------
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
--
E
--
D
--
H
-
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
-
I
---
F
Q
H
L
I
---
N
-----
T
K
------------------
F
-----
D
S
QYM
V
---------
K
----
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
---
I
E
A
E
V
K
K
I
-------
H
D
M
NYGL
K
K
Y
---
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
--
N
K
-
M
N
K
L
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
-
S
--
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
---
E
I
-
G
-
F
R
D
D
L
E
T
I
S
G
I
L
N
E
--
K
----
N
----
S
K
--
S
ADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
-
D
KNEPEAHERID
Q
S
V
V
I
S
E
K
F
A
N
S
I
F
A
A
V
-
E
H
I
-
K
-
K
-----
Q
I
K
E
-
R
D
S
N
Y
-
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
P
F
V
R
E
L
E
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
65.17
46%
-105
- C4 -
2GXQ
2
?
A:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
APS
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
64.34
46%
-102
- C4 -
2GXS
4
?
B:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
APS
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
64.31
46%
-106
- C4 -
2GXS
3
?
A:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
APS
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
63.95
46%
-106
- C4 -
3NBF
4
?
C:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
APS
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
63.67
46%
-110
- C4 -
3MWL
2
?
B:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
APS
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
63.62
46%
-99
- C4 -
3NBF
2
?
A:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
APS
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
62.99
46%
-105
- C4 -
3MWK
2
?
B:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
APS
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
62.98
46%
-107
- C4 -
3NBF
2
?
D:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
APS
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
62.67
46%
-96
- C4 -
3NBF
2
?
B:
[2-205]
--
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
--
L
A
L
--
E
--
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
-
I
---
A
-
E
R
L
A
P
S
Q
-----
E
R
------------------
G
-----
R
K
---
P
---------
R
----
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
---
V
A
S
E
L
T
A
V
-----
A
--------
P
H
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
--
E
A
-
L
L
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
-
V
--
L
D
L
-
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
---
S
M
-
G
-
F
E
E
E
V
E
A
L
---
L
S
A
--
T
----
P
----
P
S
--
R
----
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
61.62
39%
-108
- C4 -
4PX9
1
DDX3X_HUMAN
B:
[64-282]
I
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
-
I
---
L
-
S
Q
I
Y
S
-
D
-----
G
P
------------------
G
-----
E
A
---
L
---------
R
----
A
MKENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
-----
S
-
Y
R
-----
S
R
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
--
R
D
-
L
E
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
-
K
--
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
R
I
---
V
E
Q
DT
M
----
P
----
P
K
GV
R
----
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
61.53
39%
-108
- C4 -
4PX9
1
DDX3X_HUMAN
A:
[64-282]
I
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
-
I
---
L
-
S
Q
I
Y
S
-
D
-----
G
P
------------------
G
-----
E
A
---
L
---------
R
----
A
MKENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
-----
S
-
Y
R
-----
S
R
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
--
R
D
-
L
E
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
-
K
--
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
R
I
---
V
E
Q
DT
M
----
P
----
P
K
GV
R
----
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
61.30
39%
-108
- C4 -
4PX9
1
DDX3X_HUMAN
C:
[64-282]
I
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
--
I
I
K
--
E
--
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
-
I
---
L
-
S
Q
I
YS-
D
-----
G
P
------------------
G
-----
E
A
---
L
---------
R
----
A
MKENGRYGRRKQYPIS
L
V
L
A
P
T
R
E
L
A
V
Q
---
I
Y
E
E
A
R
K
F
-----
S
-
Y
R
-----
S
R
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
--
R
D
-
L
E
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
-
K
--
I
G
L
-
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
R
I
---
V
E
Q
DT
M
----
P
----
P
K
GV
R
----
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
59.18
37%
-100
- C4 -
1T6N
1
DX39B_HUMAN
A:
[16-215]
---
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
--
Q
A
I
--
L
--
G
--
M
-
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
-
T
---
L
-
Q
Q
L
---
E
-----
P
V
------------------
T
-----
G
Q
---
V
---------
S
----
V
----------------
L
V
M
C
H
T
R
E
L
A
F
Q
---
I
S
K
E
Y
E
R
F
-----
S
K
Y
M
-----
P
N
V
---
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
--
E
V
-
L
K
K
-
N
C
P
H
I
V
V
G
T
P
G
R
I
-----
L
A
L
A
-
R
N
-
K
-
S
--
L
N
L
-
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
--
Q
L
-
D
-
M
R
R
D
V
Q
E
I
---
F
R
M
--
T
----
P
----
H
E
--
K
----
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
58.96
37%
-103
- C4 -
1T6N
1
DX39B_HUMAN
B:
[16-215]
---
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
--
Q
A
I
--
L
--
G
--
M
-
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
-
T
---
L
-
Q
Q
L
---
E
-----
P
V
------------------
T
-----
G
Q
---
V
---------
S
----
V
----------------
L
V
M
C
H
T
R
E
L
A
F
Q
---
I
S
K
E
Y
E
R
F
-----
S
K
Y
M
-----
P
N
V
---
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
--
E
V
-
L
K
K
-
N
C
P
H
I
V
V
G
T
P
G
R
I
-----
L
A
L
A
-
R
N
-
K
-
S
--
L
N
L
-
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E--
Q
L
-
D
-
M
R
R
D
V
Q
E
I
---
F
R
M
--
T
----
P
----
H
E
--
K
----
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
58.89
36%
-95
- C4 -
3FE2
3
DDX5_HUMAN
A:
[30-239]
--
N
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
--
V
A
L
--
S
--
G
--
L
-
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
-
A
---
I
-
V
H
I
---
N
H
Q
PFL
E
R
------------------
G
-----
D
G
---
P
---------
I
----
C
----------------
L
V
L
A
P
T
R
E
L
A
Q
Q
---
V
Q
Q
V
A
A
E
Y
-----
C
-
R
A
-----
C
R
L
---
K
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
--
R
D
-
L
E
R
-
G
-
V
E
I
C
I
A
T
P
G
R
L
-----
I
D
F
L
-
E
C
-
G
-
K
--
T
N
L
-
R
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
K
I
---
V
D
Q
--
I
----
R
----
P
D
--
R
----
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
N
I
G
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
58.73
36%
-95
- C4 -
3FE2
4
DDX5_HUMAN
B:
[30-239]
--
N
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
--
V
A
L
--
S
--
G
--
L
-
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
-
A
---
I
-
V
H
I
---
N
HQPFL
E
R
------------------
G
-----
D
G
---
P
---------
I
----
C
----------------
L
V
L
A
P
T
R
E
L
A
Q
Q
---
V
Q
Q
V
A
A
E
Y
-----
C
-
R
A
-----
C
R
L
---
K
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
--
R
D
-
L
E
R
-
G
-
V
E
I
C
I
A
T
P
G
R
L
-----
I
D
F
L
-
E
C
-
G
-
K
--
T
N
L
-
R
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
---
D
M
-
G
-
F
E
P
Q
I
R
K
I
---
V
D
Q
--
I
----
R
----
P
D
--
R
----
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
N
I
G
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
58.61
38%
-95
- C4 -
3BER
4
DDX47_HUMAN
A:
[45-242]
---
F
K
D
L
G
V
T
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
--
L
A
L
--
Q
--
G
--
R
-
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
-
I
---
L
-
N
A
L
---
L
-----
E
T
------------------
P
-----
Q
R
---
L
---------
F
----
A
----------------
L
V
L
T
P
T
R
E
L
A
F
Q
---
I
S
E
Q
F
E
A
L
-----
G
-
S
S
-----
I
G
V
---
Q
S
A
V
I
V
G
G
I
D
S
M
S
Q
S
--
L
A
-
L
A
K
-
K
-
P
H
I
I
I
A
T
P
G
R
L
-----
I
D
H
L
E
N
T
-
K
-
G
--
F
N
L
-
R
A
L
K
Y
L
V
M
D
E
A
D
R
I
L
---
N
M
-
D
-
F
E
T
E
V
D
K
I
---
L
K
V
--
I
----
P
----
R
D
--
R
----
K
T
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
55.64
35%
-93
- C4 -
3FMO
1
DD19B_HUMAN
B:
[94-298]
---
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
--
L
M
L
AE
P
--
P
--
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
-
M
---
L
-
S
Q
V
---
E
-----
P
A
------------------
N
-----
K
Y
---
P
---------
Q
----
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
-------
Y
P
-----
E
L
K
---
L
A
Y
A
V
R
G
----
N
K
L
E
--
R
G
-
Q
K
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
L
K
-
F
--
I
D
P
-
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
--
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
---
Q
R
M
--
L
----
P
----
R
N
--
C
----
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
55.21
38%
-114
- C4 -
3IUY
2
DDX53_HUMAN
A:
[31-228]
------------
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
--
I
I
L
--
Q
--
G
--
I
-
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
---
I
-
H
L
D
---------------------------------------------------NGPG
M
----------------
L
V
L
T
P
T
R
E
L
A
L
H
---
V
E
A
E
C
S
K
Y
-----
S
-
Y
------
K
G
L
---
K
S
I
C
I
Y
G
------
Q
I
--
E
D
-
I
S
K
-
G
-
V
D
I
I
I
A
T
P
G
R
L
-----
N
D
L
Q
-
M
N
-
N
-
S
--
V
N
L
-
R
S
I
T
Y
L
V
I
D
E
A
D
K
M
L
---
D
M
-
E
-
F
E
P
Q
I
R
K
I
---
L
L
D
--
V
----
R
----
P
D
--
R
----
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
M
I
V
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
54.65
36%
-94
- C4 -
2PL3
6
DDX10_HUMAN
A:
[24-234]
I
T
R
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
--
L
A
L
--
Q
--
G
--
K
-
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
-
V
L
E
A
L
-
Y
R
L
---
Q
-----
W
T
------------------
S
-----
T
D
G--
L
---------
G
----
V
----------------
L
I
I
S
P
T
R
E
L
A
Y
Q
---
T
F
E
V
L
R
K
V
-----
G
-
K
N
-----
H
D
F
---
S
A
G
L
I
I
G
G
--
L
K
H
E
A
--
E
R
-
I
-
N
-
N
-
I
N
I
L
V
C
T
P
G
R
L
-----
L
Q
H
M
-
D
E
-
T
V
S
--
F
H
A
-
T
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
---
D
M
-
G
-
F
A
D
T
M
N
A
V
---
I
E
N
--
L
----
P
----
K
K
--
R
----
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
E
Y
V
W
V
H
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
54.48
38%
-111
- C4 -
3IUY
2
DDX53_HUMAN
B:
[31-228]
------------
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
--
I
I
L
--
Q
--
G
--
I
-
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
---
I
-
H
L
D
---
S
-----------------------------------------------NGPG
M
----------------
L
V
L
T
P
T
R
E
L
A
L
H
---
V
E
A
E
C
S
K
Y
-----
S
-
Y
------
K
G
L
---
K
S
I
C
I
Y
G
-------------------
V
D
I
I
I
A
T
P
G
R
L
-----
N
D
L
Q
-
M
N
-
N
-
S
--
V
N
L
-
R
S
I
T
Y
L
V
I
D
E
A
D
K
M
L
---
D
M
-
E
-
F
E
P
Q
I
R
K
I
---
L
L
D
--
V
----
R
----
P
D
--
R
----
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
M
I
V
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
54.45
34%
-101
- C4 -
2OXC
1
DDX20_HUMAN
B:
[26-228]
---
F
E
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
--
L
G
R
--
C
--
G
--
L
-
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
-
A
---
L
-
D
S
L
---
V
-----
L
E
------------------
N
-----
L
S
---
T
---------
Q
----
I
----------------
L
I
L
A
P
T
R
E
I
A
V
Q
---
I
H
S
V
I
T
A
I
GIKME
G
-
L
E
-----
C
H
V
---
F
I
----
G
G
T
P
L
S
Q
D
K
--
T
R
-
L
K
K
-
C
--
H
I
A
V
G
S
P
G
R
I
KQLIE
L
D
Y
L
-
N
P
-
G
-
S
--
I
R
L
------
F
I
L
D
E
A
D
K
L
L
---
E
E
-
G
S
F
Q
E
Q
I
N
W
I
---
Y
S
S
--
L
----
P
----
A
S
--
K
----
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
53.93
34%
-96
- C4 -
2OXC
1
DDX20_HUMAN
A:
[26-228]
---
F
E
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
--
L
G
R
--
C
--
G
--
L
-
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
-
A
---
L
-
D
S
L
---
V
-----
L
E
------------------
N
-----
L
S
---
T
---------
Q
----
I
----------------
L
I
L
A
P
T
R
E
I
A
V
Q
---
I
H
S
V
I
T
A
I
G
I
KME
G
-
L
E
-----
C
H
V
---
F
I
----
G
G
T
P
L
S
Q
D
K
--
T
R
-
L
K
K
-
C
--
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
D
Y
L
-
N
P
-
G
-
S
--
I
R
L
------
F
I
L
D
E
A
D
K
L
L
---
E
E
-
G
S
F
Q
E
Q
I
N
W
I
---
Y
S
S
--
L
----
P
----
A
S
--
K
----
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
46.20
33%
-87
- C4 -
3DKP
4
DDX52_HUMAN
A:
[33-220]
-----
E
Y
K
I
N
S
R
L
L
Q
N
I
L
D
A
G
F
Q
M
P
T
P
I
Q
M
Q
A
I
P
--
V
M
L
--
H
--
G
--
R
-
E
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
I
P
-
I
---
L
-
M
Q
L
---
K
-----
Q
P
------------------
A
-----
N
K
G--
F
---------
R
----
A
----------------
L
I
I
S
P
T
R
E
L
A
S
Q
---
I
H
R
E
L
I
K
I
-----
S
-
E
G
-----
T
G
F
---
R
I
H
M
I
H
K
A
A
V
A
A
K
K
F
GP
K
S
-
S
K
K
-
F
--
D
I
L
V
T
T
P
N
R
L
-----
I
Y
L
L
-
K
Q
-
D
-
P
PG
I
D
L
-
A
S
V
E
W
L
V
V
D
E
S
D
K
L
F
E
D
G---
G
-
F
R
D
Q
L
A
S
I
---
F
L
A
--
C
----
T
----
S
H
--
K
V
---
R
R
A
M
F
S
A
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------