@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0982: (2016-03-20 )
LSYEPNTKETMQKIKELTSIPSPTGNTGKIIEKLAKDLDASKIPYRLNNKGGLIVTLPGKDETKHRMLTAHVDTLGAMVKEIKADGRLLLTLIGGYRFNAIEGEYCTIETSAGDLYSGTILMHQTSVHVYKDAGTAERNDKNMEVRLDVKALDADKVRALGIEVGDFVSFDPRVQIINDEYIKSRHLDDKASVAILLQLINHIHENNLELPHTTHFLISNNEEIGYGGNSNIPAETVEYLAVDMGALGDGQTSDEYTVSICAKDGSGPYHLGLRKHLVELAKKNNIDYKVDIYPFYASDASAAINAGNDIIHGLIGPGIDASHAYERTHRDSLYHTEKLVYAYLFSNILK
Atome Classification :
(20 SA)
.........10........20....---...-.30------.........40---.....--...--------.--------50----.........60-.-.......-.70.........80........90........100.......110.---......120.......130-.-.-.....140.------...---...150.......160.......170.-.....-.180..------..-.----...190.......200......--.210....-...220.......-----.230--....---.------...---.240.......--------250-.---------------------------------------.---------------..-----.----------------...-------.---260--------------------------------------------------------...----...----.270--.------.......280.......290.-.-.....300.......310.......320..-.....330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LSYEP
N
T
K
E
T
M
Q
K
I
K
E
L
TSIPSPTG---
N
T
G
-
K
I
-------
I
E
K
L
A
K
DLDA----SKI
P
Y
--
R
LN--------N--------K-----G
G
L
I
V
TLPGK--D-ETK
H
R
M
L
-
T
A
-
H
V
D
T
L
G
A
M
V
K
E
I
KAD
G
R
L
L
L
T
L
IGG
Y
R
FNAIEG
E
Y
C
T
I
ETSAG---D
L
Y
S
G
T
I
L
M
H
Q
T
S
V
H
V
Y
KD-A-G-TAERNDK
N
M
------
E
V
R
---
L
D
V
K
ALDADK
V
R
A
L
GIEVGDFVSFDP
R
-
V
Q
I
I
N
-
D
E
-
Y
I
K
------SR-H----LD
D
K
A
S
V
A
I
L
L
Q
L
I
N
H
I
H
ENNL--ELPHT
T
H
F
-
L
ISN-NEEIGYGG-----NS----NI
P
A
---
E
------
T
V
E
---
Y
L
A
V
D
MGALGD--------G---Q---------------------------------------T---------------SD-----
E
----------------
Y
T
V
-------
S
---
I
C
A--------------------------------------------------------KDG----SGP----
Y
H
L---
G
------
L
R
K
H
L
V
E
L
A
K
KNNI
D
Y
K
V
D
I
Y
-
P
-
F
YASDASAAINAG
N
D
I
I
H
G
LIGPGI
D
A
S
H
A
-
Y
E
R
THRDS
L
Y
H
T
E
K
L
V
Y
A
Y
L
F
S
N
ILK
1
PsiBlast_PDB
98.95
69%
-101
- C2 -
2GRE
1
?
A:
[4-348]
-----
H
T
K
E
T
M
E
L
I
K
E
L
V
S
I
P
S
P
S
G
---
N
T
A
-
K
I
-------
I
N
F
I
E
N
Y
V
S
E
----
W
N
V
E
T
--
K
R
N
--------
N
--------
K
-----
G
A
L
I
L
T
V
K
G
K
--
N
-
D
A
Q
H
R
L
L
-
T
A
-
H
V
D
T
L
G
A
M
V
K
E
I
K
P
D
G
R
L
S
L
S
M
I
G
G
F
R
W
N
S
V
E
G
E
Y
C
E
I
E
T
S
S
G
---
K
T
Y
T
G
T
I
L
M
H
----------------------
I
------
E
V
R
---
I
D
E
R
V
F
S
A
D
E
V
R
E
L
G
I
E
V
G
D
F
V
S
F
D
P
R
-
V
Q
I
T
E
-
S
G
-
Y
I
K
------
S
R
-
H
----
L
D
D
K
V
S
V
A
I
L
L
K
L
I
K
R
L
Q
D
E
N
V
--
T
L
P
Y
T
T
H
F
-
L
I
S
N
-
N
E
----
G
G
-----
N
S
----
N
I
P
E
---
E
------
T
V
E
---
Y
L
A
V
D
M
G
A
L
G
D
--------
G
-----------------------------------------------------------
S
D
-----
E
----------------
Y
T
V
-------
S
---
I
C
A
--------------------------------------------------------
K
D
S
----
S
G
P
----
Y
H
Y
---
A
------
L
R
K
H
L
V
E
L
A
K
T
N
H
I
E
Y
K
V
D
I
Y
-
P
-
Y
Y
--------
R
A
G
F
D
V
K
H
A
L
I
G
A
G
I
D
S
S
H
A
-
F
E
R
T
H
E
S
S
I
A
H
T
E
A
L
V
Y
A
Y
V
M
S
N
L
I
E
21
HHSearch
98.65
70%
-97
- C2 -
2GRE
1
?
A:
[3-346]
----
H
H
T
K
E
T
M
E
L
I
K
E
L
V
S
I
P
S
P
S
G
---
N
T
A
-
K
I
-------
I
N
F
I
E
N
Y
V
S
E
----
W
N
V
E
T
--
K
R
N
--------
N
--------
K
-----
G
A
L
I
L
T
V
K
G
K
--
N
-
D
A
Q
H
R
L
L
-
T
A
-
H
V
D
T
L
G
A
M
V
K
E
I
K
P
D
G
R
L
S
L
S
M
I
G
G
F
R
W
N
S
V
E
G
E
Y
C
E
I
E
T
S
S
G
---
K
T
Y
T
G
T
I
L
M
H
--------------------
I
E
--------
V
R
---
I
D
E
R
V
F
S
A
D
E
V
R
E
L
G
I
E
V
G
D
F
V
S
F
D
P
R
-
V
Q
I
T
E
-
S
G
-
Y
I
K
------
S
R
-
H
----
L
D
D
K
V
S
V
A
I
L
L
K
L
I
K
R
L
Q
D
E
N
V
--
T
L
P
Y
T
T
H
F
-
L
I
S
N
-
N
E
----
G
G
-----
N
S
----
N
I
P
E
---
E
------
T
V
E
---
Y
L
A
V
D
M
G
A
L
G
D
--------
G
-----------------------------------------------------------
S
D
-----
E
----------------
Y
T
V
-------
S
---
I
C
A
--------------------------------------------------------
K
D
S
----
S
G
P
----
Y
H
Y
---
A
------
L
R
K
H
L
V
E
L
A
K
T
N
H
I
E
Y
K
V
D
I
Y
-
P
-
Y
Y
--------
R
A
G
F
D
V
K
H
A
L
I
G
A
G
I
D
S
S
H
A
-
F
E
R
T
H
E
S
S
I
A
H
T
E
A
L
V
Y
A
Y
V
M
S
N
L
--
23
HHSearch
67.91
19%
-71
- C2 -
1YLO
2
?
A:
[3-338]
-------
A
M
D
L
S
L
L
K
A
L
S
E
A
D
A
I
A
S
---
S
E
Q
-
E
V
-------
R
Q
I
L
L
E
E
A
A
R
----
L
Q
K
E
V
--
R
F
D
--------
G
--------
L
-----
G
S
V
L
I
R
L
N
E
S
----
T
G
P
K
V
M
I
-
C
A
-
H
M
D
E
V
G
F
M
V
R
S
I
S
R
E
G
A
I
D
V
L
P
V
G
N
V
R
M
A
A
R
Q
L
Q
P
V
R
I
T
T
R
E
E
---
C
K
I
P
G
L
L
D
G
-------------
D
-
R
Q
G
N
D
V
S
A
M
------
R
-----
V
D
I
G
A
R
T
Y
D
E
V
M
Q
A
G
I
R
P
G
D
R
V
T
F
D
T
T
-
F
Q
V
L
P
-
H
Q
-
R
V
M
------
G
K
-
A
----
F
D
D
R
L
S
C
Y
L
L
V
T
L
L
R
E
L
H
D
A
----
E
L
P
A
E
V
W
L
-
V
A
S
S
-
S
E
E
V
G
L
R
G
-----
G
Q
----
T
A
T
R
A
V
-
S
------
P
D
V
---
A
I
V
L
D
T
A
C
W
A
K
--------
N
---
F
DYGAANH--------------------------------
R
---------------
Q
I
-----
G
----------------
N
G
P
-------
M
---
L
V
L
--------------------------------------------------------
S
D
K
----
S
L
I
----
A
P
P
---
K
------
L
T
A
W
I
E
T
V
A
A
E
I
G
V
P
L
Q
A
D
M
F
-
S
-
N
G
G
T
D
G
G
A
V
H
L
T
G
T
G
V
P
T
L
V
M
G
P
A
T
R
H
G
H
C
A
A
S
I
A
D
C
R
D
I
L
Q
M
E
Q
L
L
S
A
L
I
Q
R
L
T
R
-
29
HHSearch
64.30
24%
-66
- C2 -
2WYR
2
?
A:
[2-332]
-------
M
S
M
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
---
Y
E
E
-
R
I
-------
R
E
E
I
I
R
E
I
K
D
----
F
A
-
D
Y
--
K
V
D
--------
A
--------
I
-----
G
N
L
I
V
E
L
G
E
-----
G
E
E
R
I
L
F
-
M
A
-
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
----
I
L
D
G
V
I
G
A
--
T
P
P
H
L
--------
K
S
V
I
P
W
Y
D
L
------
V
-----
I
D
I
G
A
E
S
K
E
E
A
L
E
-
L
V
K
P
L
D
F
A
V
F
K
K
H
-
F
S
V
L
N
-
G
K
-
Y
V
S
------
T
R
-
G
----
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
V
D
H
----
E
L
E
G
K
V
I
F
-
A
F
T
V
-
Q
E
E
V
G
L
K
G
-----
A
K
----
F
L
A
N
H
Y
-
Y
------
P
Q
Y
---
A
F
A
I
D
S
F
A
C
C
S
--------
P
LTG
D
---------------------------------------
V
---------------
K
L
-----
G
----------------
K
G
P
-------
V
---
I
R
A
--------------------------------------------------------
V
D
N
----
S
A
I
----
Y
S
R
---
D
------
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
G
V
T
---
G
G
G
T
D
A
S
A
F
Q
D
---
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
E
A
L
A
F
E
L
---
24
HHSearch
63.82
20%
-80
- C2 -
2FVG
3
?
A:
[2-335]
-----------
M
Y
L
K
E
L
S
M
M
P
G
V
S
G
---
D
E
G
-
K
V
-------
R
D
F
I
K
S
K
I
E
G
----
L
V
D
N
L
--
Y
T
D
--------
V
--------
L
-----
G
N
L
I
A
L
K
R
G
R
--
D
-
S
S
K
K
L
L
V
-
S
A
-
H
M
D
E
V
G
F
V
V
S
K
I
E
K
D
G
K
V
S
F
L
P
V
G
G
V
D
P
R
I
L
P
G
K
V
V
Q
V
K
N
--------
L
K
G
V
I
G
Y
--
R
--------------
P
P
R
F
E
N
L
------
R
-----
I
D
F
G
F
S
S
A
D
E
A
K
K
-
Y
V
S
I
G
D
Y
V
S
F
V
S
D
-
Y
I
E
-
K
-
N
G
-
R
A
V
------
G
K
-
A
----
F
D
D
R
A
G
C
S
V
L
I
D
V
L
E
S
G
V
S
------
P
A
Y
D
T
Y
F
-
V
F
T
V
-
Q
E
E
----------
S
A
----
V
V
V
E
Q
L
-
K
------
P
T
C
---
A
I
V
V
E
T
T
T
A
G
D
--------
N
---
P
ELEERKWA-------------------------------
T
---------------
H
L
-----
G
----------------
D
G
P
-------
A
---
I
T
F
--------------------------------------------------------
Y
H
R
----
G
Y
V
----
I
P
K
---
E
------
I
F
Q
T
I
V
D
T
A
K
N
N
D
I
P
F
Q
M
K
R
R
-
T
--------------
Y
G
V
P
A
G
V
I
S
T
P
A
R
Y
I
H
S
P
N
S
I
I
D
L
N
D
Y
E
N
T
K
K
L
I
K
V
L
V
E
E
G
K
I
-
13
PsiBlast_PDB
63.38
23%
-66
- C2 -
3KL9
2
?
A:
[6-340]
----------
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
---
H
E
A
-
P
V
-------
R
A
Y
L
R
E
K
L
T
P
----
H
V
D
E
V
--
V
T
D
--------
G
--------
L
-----
G
G
I
F
G
I
K
H
S
E
--
A
-
V
D
A
P
R
V
L
-
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
------------------------
P
A
I
A
------
D
I
V
---
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
-
E
K
-
N
I
I
------
S
K
-
A
----
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
K
L
GN
E
L
-----
Y
-
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
---
T
S
----
T
T
K
F
---
D
------
P
E
V
---
F
L
A
V
D
C
S
P
A
G
D
VYGGQ---
G
---
K
---------------------------------------
I
---------------
G
D
-----
G
----------------
T
L
I
-------
R
---
F
Y
D
-----------------------------------------------------------------
P
----
G
H
L
L
L
P
G
------
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
-------
Y
Y
C
G
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
-
Y
I
H
S
H
Q
-
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
-
28
HHSearch
62.34
21%
-61
- C2 -
1VHE
1
YSDC_BACSU
A:
[5-354]
-----
K
L
D
E
T
L
T
M
L
K
D
L
T
D
A
K
G
I
P
G
---
N
E
R
-
E
V
-------
R
Q
V
M
K
S
Y
I
E
P
----
F
A
D
E
V
--
T
T
D
--------
R
--------
L
-----
G
S
L
I
A
K
K
T
G
A
--
E
-
N
G
P
K
I
M
I
-
A
G
-
H
L
D
E
V
G
F
M
V
T
Q
I
T
D
K
G
F
I
R
F
Q
T
V
G
G
W
W
A
Q
V
M
L
A
Q
R
V
T
I
V
T
K
K
----
G
E
I
T
G
V
I
G
S
--
K
P
P
H
I
L
S
P
-
E
A
R
-
K
K
S
V
E
I
K
D
M
------
F
-----
I
D
I
G
A
S
S
R
E
E
A
L
E
W
G
V
L
P
G
D
M
I
V
P
H
F
E
-
F
T
V
M
N
N
E
K
-
F
L
L
------
A
K
-
A
----
W
D
N
R
I
G
C
A
I
A
I
D
V
L
R
N
L
Q
N
T
----
D
H
P
N
I
V
Y
G
-
V
G
T
V
-
Q
E
E
V
G
L
R
G
-----
A
K
----
T
A
A
H
T
I
-
Q
------
P
D
I
---
A
F
G
V
D
V
G
I
A
G
D
--------
T
---
P
GISEKEAQ-------------------------------
S
---------------
K
M
-----
G
----------------
K
G
P
-------
Q
---
I
I
V
--------------------------------------------------------
Y
D
A
----
S
M
V
----
S
H
K
---
G
------
L
R
D
A
V
V
A
T
A
E
E
A
G
I
P
Y
Q
F
D
A
I
-
A
-
G
G
G
T
D
S
G
A
I
H
L
T
A
N
G
V
P
A
L
S
I
T
I
A
T
R
Y
I
H
T
H
A
A
M
L
H
R
D
D
Y
E
N
A
V
K
L
I
T
E
V
I
K
K
L
D
R
-
22
HHSearch
61.74
20%
-57
* C2 *
3KL9
2
?
A:
[2-346]
------
M
T
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
---
H
E
A
-
P
V
-------
R
A
Y
L
R
E
K
L
T
P
----
H
V
D
E
V
--
V
T
D
--------
G
--------
L
-----
G
G
I
F
G
I
K
H
S
E
--
A
V
D
A
P
R
V
L
V
-
A
S
-
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
---
H
E
I
P
V
I
S
G
-------------------
P
A
I
A
D
I
------
V
-----
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
-
A
I
L
T
A
N
E
K
-
N
I
I
------
S
K
-
A
----
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
----
K
L
G
N
E
L
Y
L
-
G
S
N
V
-
Q
E
E
V
G
L
R
G
-----
A
H
----
T
S
T
T
K
F
-
D
------
P
E
V
---
F
L
A
V
D
C
S
P
A
G
D
--------
V
---
Y
GGQ------------------------------------
G
---------------
K
I
-----
G
----------------
D
G
T
-------
L
---
I
R
F
--------------------------------------------------------
Y
D
P
----
G
H
L
----
L
L
P
---
G
------
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
G
---
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
-
25
HHSearch
61.45
19%
-70
- C2 -
2WZN
6
?
A:
[8-349]
------
S
M
V
D
W
K
L
M
Q
E
I
I
E
A
P
G
V
S
G
---
Y
E
H
L
G
I
-------
R
D
I
V
V
D
V
L
K
E
----
V
A
D
E
V
--
K
V
D
--------
K
--------
L
-----
G
N
V
I
A
H
F
K
G
S
-----
S
P
R
I
M
V
-
A
A
-
H
M
D
K
I
G
V
M
V
N
H
I
D
K
D
G
Y
L
H
I
V
P
I
G
G
V
L
P
E
T
L
V
A
Q
R
I
R
F
F
T
E
K
----
G
E
R
Y
G
V
V
G
V
--
L
P
P
H
L
R
----------
I
D
W
D
Q
I
------
V
-----
V
D
V
G
A
S
S
K
E
E
A
E
E
M
G
F
R
V
G
T
V
G
E
F
A
P
N
-
F
T
R
L
N
-
E
H
-
R
F
A
------
T
P
-
Y
----
L
D
D
R
I
C
L
Y
A
M
I
E
A
A
R
Q
L
G
D
------
H
E
A
D
I
Y
I
-
V
G
S
V
-
Q
E
E
V
G
L
R
G
-----
A
R
----
V
A
S
Y
A
I
-
N
------
P
E
V
---
G
I
A
M
D
V
T
F
A
K
Q
--------
P
---
H
DKGKIV---------------------------------
P
---------------
E
L
-----
G
----------------
K
G
P
-------
V
---
M
D
V
--------------------------------------------------------
G
-------
P
N
----
I
N
P
---
K
------
L
R
A
F
A
D
E
V
A
K
K
Y
E
I
P
L
Q
V
E
P
S
P
R
-
P
T
G
T
D
A
N
V
M
Q
I
N
K
E
G
V
A
T
A
V
L
S
I
P
I
R
Y
M
H
S
Q
V
E
L
A
D
A
R
D
V
D
N
T
I
K
L
A
K
A
L
L
E
E
L
K
P
-
26
HHSearch
60.30
20%
-76
- C2 -
3ISX
3
?
A:
[11-342]
-------
H
H
M
K
E
L
I
R
K
L
T
E
A
F
G
P
S
G
---
R
E
E
-
E
V
-------
R
S
I
I
L
E
E
L
E
G
----
H
I
D
G
H
--
R
I
D
--------
G
--------
L
-----
G
N
L
I
V
W
K
G
S
-----
G
E
K
K
V
I
L
-
D
A
-
H
I
D
E
I
G
V
V
V
T
N
V
D
D
K
G
F
L
T
I
E
P
V
G
G
V
S
P
Y
M
L
L
G
K
R
I
R
F
E
N
G
-------
T
I
G
V
V
G
M
--
E
G
E
T
T
E
E
R
Q
E
-
N
-
V
R
K
L
S
F
D
K
L
------
F
-----
I
D
I
G
A
N
S
R
E
E
A
Q
K
-
M
C
P
I
G
S
F
G
V
Y
D
S
G
-
F
V
E
V
--
S
G
-
K
Y
V
------
S
K
-
A
----
M
D
D
R
I
G
C
A
V
I
V
E
V
F
K
R
I
K
-------
P
A
V
T
L
Y
G
-
V
F
S
V
-
Q
E
E
V
G
L
V
G
-----
A
S
----
V
A
G
Y
GV-
P
------
A
D
E
---
A
I
A
I
D
V
T
D
S
A
D
--------
T
---
P
KAIKRHA--------------------------------
M
---------------
R
L
-----
S
----------------
G
G
P
-------
A
---
L
K
V
--------------------------------------------------------
K
D
R
----
A
S
I
----
S
S
K
---
R
------
I
L
E
N
L
I
E
I
A
E
K
F
D
I
K
Y
Q
M
E
V
L
-
T
-
F
G
G
T
N
A
M
G
Y
Q
R
T
R
E
G
I
P
S
A
T
V
S
I
P
T
R
Y
V
H
S
P
S
E
M
I
A
P
D
D
V
E
A
T
V
D
L
L
I
R
Y
L
G
-----
6
PsiBlast_PDB
58.46
21%
-77
- C2 -
1VHE
1
YSDC_BACSU
A:
[8-306]
--------
E
T
L
T
M
L
K
D
L
T
D
A
K
G
I
P
G
---
N
E
R
-
E
V
R
Q
V
M
K
S
Y
I
E
P
F
A
D
E
V
T
T
----
D
R
L
------------------------------
G
S
L
I
A
K
K
T
G
A
--
E
-
N
G
P
K
I
M
I
-
A
G
-
H
L
D
E
V
G
F
M
V
T
Q
I
T
D
K
G
F
I
R
F
Q
T
V
G
G
W
W
A
Q
V
M
L
A
Q
R
V
T
I
V
T
K
K
G
---
E
I
---
T
G
V
I
G
S
K
P
P
H
I
L
-------
S
P
E
A
R
K
K
S
V
------
E
I
K
D
M
F
I
D
I
G
A
S
S
R
E
E
A
L
E
W
G
V
L
P
G
D
M
I
V
P
H
F
E
-
F
T
V
M
N
-
N
E
K
F
L
L
------
A
K
-
A
----
W
D
N
R
I
G
C
A
I
A
I
D
V
L
R
N
L
Q
--
N
T
--
D
H
P
N
I
V
Y
G
-
V
G
T
V
-
Q
E
E
V
G
L
R
G
------
A
----
K
T
A
A
---
H
------
T
I
Q
PD
I
A
F
G
V
D
V
G
I
A
G
D
TPGISEKE
A
---
Q
---------------------------------------
S
---------------
K
M
-----
G
----------------
K
G
P
-------
Q
---
I
I
V
--------------------------------------------------------
Y
D
A
----
S
M
V
----
S
H
K
---
G
------
L
R
D
A
V
V
A
T
A
E
E
A
G
I
P
Y
Q
F
D
A
I
-
A
-
G
G
G
T
D
S
G
A
-------------------------------------------------
12
PsiBlast_PDB
57.87
22%
-93
- C2 -
3ISX
3
?
A:
[17-296]
-------------
I
R
K
L
T
E
A
F
G
P
S
G
---
R
E
E
-
E
V
-------
R
S
I
I
L
E
E
L
E
G
----
H
I
D
G
H
--
R
I
D
--------
G
--------
L
-----
G
N
L
I
V
-
W
K
G
S
--
G
-
E
-
K
K
V
I
L
-
D
A
-
H
I
D
E
I
G
V
V
V
T
N
V
D
D
K
G
F
L
T
I
E
P
V
G
G
V
S
P
Y
M
L
L
G
K
R
I
R
F
E
----------
N
G
T
I
G
V
------
V
G
M
E
-
G
-
E
-
T
T
E
E
R
Q
E
N
V
R
K
LSFD
K
L
F
---
I
D
I
G
A
N
S
R
E
E
A
Q
K
M
-
C
P
I
G
S
F
G
V
Y
D
S
G
-
F
V
E
V
S
-
G
K
-
Y
V
-------
S
K
-
A
----
M
D
D
R
I
G
C
A
V
I
V
E
V
F
K
R
I
K
--------
P
A
V
T
L
Y
G
V
F
S
V
-
Q
E
E
V
G
L
V
G
-----
A
S
VAGY
G
V
P
A
---
D
--------
E
---
A
I
A
I
D
V
T
D
S
A
D
--------
T
---
P
---------------------------------------
K
---------------
A
I
-----
K
----------------
R
H
A
MRLSG
G
P
A
---
L
K
V
--------------------------------------------------------
K
D
R
----
A
S
I
----
S
S
K
---
R
------
I
L
E
N
L
I
E
I
A
E
K
F
D
I
K
Y
Q
M
E
V
L
-
T
-
F
G
G
T
N
A
---------------------------------------------------
9
PsiBlast_PDB
56.84
22%
-85
- C2 -
4P6Y
-
?
A:
[5-284]
-------------
I
R
K
L
T
E
A
F
G
P
S
G
---
R
E
E
-
E
V
-------
R
S
I
I
L
E
E
L
E
G
----
H
I
D
G
H
--
R
I
D
--------
G
--------
L
-----
G
N
L
I
V
-
W
K
G
S
--
G
-
E
-
K
K
V
I
L
-
D
A
-
H
I
D
E
I
G
V
V
V
T
N
V
D
D
K
G
F
L
T
I
E
P
V
G
G
V
S
P
Y
M
L
L
G
K
R
I
R
F
E
----------
N
G
T
I
G
V
------
V
G
M
E
-
G
-
E
-
T
T
E
E
R
Q
E
N
V
R
KLSFD
K
L
F
---
I
D
I
G
A
N
S
R
E
E
A
Q
K
M
-
C
P
I
G
S
F
G
V
Y
D
S
G
-
F
V
E
V
S
-
G
K
-
Y
V
-------
S
K
-
A
----
M
D
D
R
I
G
C
A
V
I
V
E
V
F
K
R
I
K
--------
P
A
V
T
L
Y
G
V
F
S
V
-
Q
E
E
V
G
L
V
G
-----
A
S
V
A
GY
G
V
P
A
---
D
--------
E
---
A
I
A
I
D
V
T
D
S
A
D
--------
T
---
P
---------------------------------------
K
---------------
A
I
-----
K
----------------
R
H
A
MRLSG
G
P
A
---
L
K
V
--------------------------------------------------------
K
D
R
----
A
S
I
----
S
S
K
---
R
------
I
L
E
N
L
I
E
I
A
E
K
F
D
I
K
Y
Q
M
E
V
L
-
T
-
F
G
G
T
N
A
---------------------------------------------------
32
HHSearch
54.81
21%
-68
- C2 -
3CPX
10
?
A:
[13-321]
---
E
N
L
Y
F
Q
G
M
Q
L
L
K
E
L
C
S
I
H
A
P
S
G
---
N
E
E
-
P
L
-------
K
D
F
I
L
E
Y
I
R
S
N
A
GS
W
S
Y
Q
P
V
I
Y
A
D
N-------
D
--------
L
-----
Q
D
C
I
V
L
V
F
G
------
N
P
R
T
A
V
-
F
A
-
H
M
D
S
I
G
F
T
V
S
Y
N
N
-----
H
L
H
P
I
G
S
P
S
A
--
K
E
G
Y
R
L
V
G
K
D
S
N
G
----
D
I
E
G
V
L
K
I
--
V
D
E
E
W
------------------------------------
M
L
E
T
-
D
R
L
I
D
R
G
T
E
V
T
F
K
P
D
-
F
R
E
E
--
G
D
-
F
I
L
------
T
P
-
Y
----
L
D
D
R
L
G
V
W
T
A
L
E
L
A
K
T
L
E
H
----------
G
I
I
-
A
F
T
C
-
W
E
E
H
G
G
G
S
-----
V
A
----
Y
L
A
R
---
W
I
Y
E
T
FH
V
K
Q
---
S
L
I
C
D
I
T
W
V
T
E
--------
G
-------------------------------------------
V
---------------
E
A
-----
G
----------------
K
G
V
-------
A
---
I
S
M
--------------------------------------------------------
R
D
R
-----
M
I
----
P
R
K
---
K
------
Y
V
N
R
I
I
E
L
A
R
Q
T
D
I
P
F
Q
L
E
V
E
-
G
-
A
G
A
S
D
G
R
E
L
Q
L
S
P
Y
P
W
D
W
C
F
I
G
A
P
E
K
D
A
H
T
P
N
E
C
V
H
K
K
D
I
E
S
M
V
G
L
Y
K
Y
L
M
E
K
L
---
37
HHSearch
54.36
23%
-45
- C2 -
3RZA
10
?
A:
[19-394]
--
G
M
I
N
E
Q
R
L
L
N
T
F
L
E
L
V
Q
I
D
S
E
T
G
---
N
E
S
-
T
I
-------
Q
P
I
L
K
E
K
F
I
A
----
L
G
L
D
V
--
K
E
D
--------
E
AAKHPKLG
A
-----
N
N
L
V
C
T
M
N
S
T
IE---
V
P
K
L
Y
L
-
T
S
-
H
M
D
T
V
V
P
-----------------
A
I
N
V
K
P
I
------------------------------------------------------------------------------------------
V
K
D
-
D
G
-
Y
I
Y
------
S
D
G
T
TILG
A
D
D
K
A
G
L
A
A
M
L
E
V
L
Q
V
I
K
E
Q
Q
---
I
P
H
G
Q
I
Q
F
-
V
I
T
V
-
G
E
E
S
G
L
I
G
-----
A
K
----
E
L
N
S
ELL
D
------
A
D
F
---
G
Y
A
I
D
A
S
A
D
V
G
--------
T
---
T
V
V
G
A
P
T
Q
M
L
I
S
A
K
I
I
G
K
T
A
HAST----------------
P
KE
G
V
S
A
I
N
I
A
A
K
A
I
S
R
M
-----
K
LGQVDEI
T
T
A
N
IG
K
F
H
G
G
S
-------
A
---
T
N
I
VAD
E
V
I
L
E
A
E
A
R
S
HD
P
E
R
I
K
T
Q
V
K
H
M
T
D
V
F
E
T
T
A
S
E
L
G
G
K
A
E
V
T
V
-----------
E
Q
S
Y
P
G
F
K
I
N
----
D
N
E
---
A
------
V
V
K
I
A
Q
E
S
A
R
N
L
G
L
S
A
N
T
I
I
--
S
-
G
G
G
S
D
G
S
I
I
N
T
--
F
G
I
P
S
V
I
L
G
V
G
Y
E
K
I
H
T
T
N
E
R
M
P
I
K
S
L
N
L
L
A
S
Q
V
L
E
I
I
K
I
V
A
R
Q
3
PsiBlast_PDB
54.32
23%
-70
- C2 -
2FVG
3
?
A:
[4-287]
-------------
L
K
E
L
S
M
M
P
G
V
S
G
---
D
E
G
-
K
V
------------
R
D
F
I
K
----
S
K
I
E
G
--
L
V
D
--------
N
--------
L
Y
T
D
VL
G
N
L
I
A
L
K
R
G
R
--
D
-
S
S
K
K
L
L
V
-
S
A
-
H
M
D
E
V
G
F
V
V
S
K
I
E
K
D
G
K
V
S
F
L
P
V
G
G
V
D
P
R
I
L
P
G
K
V
V
Q
V
K
N
L
K
G
----------
V
I
G
Y
R
--------------
P
P
R
F
E
N
L
--------
R
---
I
D
F
G
F
S
S
A
D
E
A
K
K
Y
-
V
S
I
G
D
Y
V
S
F
-------
V
S
-
D
--
Y
I
E
K
NG
R
A
V
G
K
-
A
----
F
D
D
R
A
G
C
S
V
L
I
D
V
L
----
E
S
G
V
--
S
P
A
Y
D
T
Y
F
-
V
F
T
V
-
Q
E
E
----------
S
A
----
V
V
V
E
---
Q
------
L
K
P
---
T
C
A
I
V
V
E
T
T
T
A
--------
G
---
D
---------------------------------------
N
---------------
P
E
-----
L
----------------
E
E
R
-------
K
---
W
A
T
--------------------------------------------------------
H
L
G
----
D
G
P
A
I
T
F
Y
H
R
---
G
YVIP
K
E
I
F
Q
T
I
V
D
T
A
K
N
N
D
I
P
F
Q
----------------------------------------------------------------
38
HHSearch
54.08
23%
-51
- C2 -
3GB0
7
?
A:
[3-372]
----
I
N
Q
E
R
L
V
N
E
F
M
E
L
V
Q
V
D
S
E
T
K
---
F
E
A
-
E
I
-------
C
K
V
L
T
K
K
F
T
D
----
L
G
V
E
V
--
F
E
D
DTMAVTGH
G
--------
A
-----
G
N
L
I
C
T
L
P
A
T
--
K
D
G
V
D
T
I
Y
F
-
T
S
-
H
M
D
T
V
V
P
G
------
N
---------
G
I
-----
K
P
----------------------------------------------------------------------------------------
S
I
K
-
D
G
-
Y
I
V
------
S
D
G
T
TILG
A
D
D
K
A
G
L
A
S
M
F
E
A
I
R
V
L
K
E
K
N
---
I
P
H
G
T
I
E
F
-
I
I
T
V
-
G
E
E
S
G
L
V
G
-----
A
K
----
A
L
D
R
---
E
RIT---
A
K
Y
---
G
Y
A
L
D
S
D
G
K
V
G
--------
E
---
I
VV
A
A
P
T
Q
A
K
V
N
A
I
I
R
G
K
T
A
HAGVAPEK
G
V
S
A
I
T
I
A
A
K
A
I
A
---------------
K
M
PLGRI
D
----------------
S
E
T
-------
T
---
A
N
I
G
R
F
E
G
G
T
Q
TNIVCD
H
V
Q
I
F
A
E
A
R
S
LI
N
E
K
M
E
A
Q
V
A
K
M
K
E
A
F
E
T
T
A
K
E
M
G
G
H
A
D
V
E
V
N
V
M
Y
P
G
F
K
F
A
----
D
G
D
---
H
------
V
V
E
V
A
K
R
A
A
E
K
I
G
R
T
P
S
L
H
Q
--
S
-
G
G
G
S
D
A
N
V
I
A
G
--
H
G
I
P
T
V
N
L
A
V
G
Y
E
E
I
H
T
T
N
E
K
I
P
V
E
E
L
A
K
T
A
E
L
V
V
A
I
I
E
E
V
A
--
7
PsiBlast_PDB
53.83
25%
-58
- C2 -
2CF4
2
?
A:
[5-289]
----------
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
YE
E
R
I
R
-
E
E
-------
I
I
R
E
I
K
D
F
--------
A
D
Y
--
K
V
D
--------
A
--------
I
-----
G
N
L
I
V
E
L
-----
G
-
E
G
E
E
R
I
L
F
M
A
-
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
---
I
L
-
D
G
V
I
G
A
T
P
P
H
L
S
L
E
R
D
-
K
-
S
-
V
I
P
W
Y
D
L
V
I
------
D
I
G
---
A
E
S
K
E
E
A
L
E
L
V
K
P
L
-----
D
F
A
V
F
K
K
H
-
F
S
V
L
N
-
G
K
-
Y
V
S
------
T
R
-
G
----
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
V
D
H
E
L
--
E
--
G
K
V
I
F
-
A
F
T
V
-
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
----
Y
Y
P
Q
---
Y
------
A
------
F
A
I
D
S
F
A
C
C
S
--------
P
---
L
---------------------------------------
T
---------------
G
D
-----
V
----------------
K
L
G
-------
K
GPV
I
R
A
--------------------------------------------------------
V
D
N
----
S
A
I
----
Y
S
R
---
D
------
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
G
V
T
-
G
--
G
G
T
D
A
S
A
-------------------------------------------------
5
PsiBlast_PDB
51.32
25%
-62
- C2 -
2WYR
2
?
A:
[5-289]
----------
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
YE
E
R
I
R
-
E
E
-------
I
I
R
E
I
K
D
F
--------
A
D
Y
--
K
V
D
--------
A
--------
I
-----
G
N
L
I
V
E
L
-----
G
-
E
G
E
E
R
I
L
F
M
A
-
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
---
I
L
-
D
G
V
I
G
A
T
P
P
H
L
------
K
-
S
-
V
I
P
W
Y
D
L
V
I
------
D
I
G
---
A
E
S
K
E
E
A
L
E
L
V
K
P
L
-----
D
F
A
V
F
K
K
H
-
F
S
V
L
N
-
G
K
-
Y
V
S
------
T
R
-
G
----
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
V
D
H
E
L
--
E
--
G
K
V
I
F
-
A
F
T
V
-
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
----
Y
Y
P
Q
---
Y
------
A
------
F
A
I
D
S
F
A
C
C
S
--------
P
---
L
---------------------------------------
T
---------------
G
D
-----
V
----------------
K
L
G
-------
K
GPV
I
R
A
--------------------------------------------------------
V
D
N
----
S
A
I
----
Y
S
R
---
D
------
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
G
V
T
-
G
--
G
G
T
D
A
S
A
-------------------------------------------------
31
HHSearch
50.45
18%
-66
- C2 -
1VHO
4
?
A:
[5-335]
-------
M
E
T
G
K
L
L
M
E
L
S
N
L
D
G
P
S
G
---
Y
E
T
-
N
V
-------
V
S
Y
I
K
S
V
I
E
P
----
F
V
D
E
A
--
K
T
T
--------
R
--------
H
-----
G
S
L
I
G
Y
K
K
G
K
--
G
--
I
G
K
L
A
F
-
F
A
-
H
V
D
E
I
G
F
V
V
S
K
V
E
-
G
Q
F
A
R
L
E
P
V
--------
Y
A
S
K
V
R
I
Y
T
K
N
G
----
I
E
R
G
V
I
G
M
--
L
A
P
H
L
Q
D
S
-
E
-
S
R
K
K
V
P
T
Y
D
E
I
------
F
-----
V
D
L
S
L
------
C
E
R
G
V
R
V
G
D
I
A
V
I
D
Q
T
-
A
F
E
T
N
--
G
-
K
V
V
------
G
K
-
A
----
L
D
N
R
A
S
C
G
V
L
V
K
V
L
E
F
L
K
R
Y
----
D
H
P
W
D
V
Y
V
-
V
F
S
V
-
Q
E
E
T
G
C
L
G
-----
A
L
----
T
G
A
Y
EI-
N
------
P
D
A
---
A
I
V
M
D
V
T
F
A
S
E
--------
P
---
P
F
S
D
H
-----------------------------------
I
---------------
E
L
-----
G
----------------
K
G
P
-------
V
---
I
G
L
--------------------------------------------------------
G
P
-------
V
----
V
D
R
---
N
------
L
V
Q
K
I
I
E
I
A
K
K
H
N
V
S
L
Q
E
E
A
V
-
G
G
R
----
T
D
F
V
Q
L
V
R
N
G
V
R
T
S
L
I
S
I
P
L
K
Y
M
H
T
P
V
E
M
V
D
P
R
D
V
E
E
L
A
R
L
L
S
L
V
A
V
E
L
E
--