@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1039: (2016-03-21 )
MLRLQFHKKLPFHDLNIDYTFEKPVTAMMGASGSGKSTLFQCVSGLKSIDGGIIEFDGTPWDDSNISLHLPVTERKVGYLFQNLALFPNMNVYENIAFGLKVKKKKKKEQAEIQQQVRKMSDYLQISHLLYSSVQKLSGGEKQRVAMARAMITEPKLLLLDEPFNGLDEETRLICMKLVGQMAKDFHIPVIFVTHYASEAEMMTEEILVMREGRLEKRKS
Atome Classification :
(51 SA)
---------....-.....10.---.......20.---.-.---.....30........40........50........60........70....-....80.--..-.....90........-100--........-----.110.......120...-..-..130...---....140.......150.......160.......170-------.......180.......190.......200.......210.......220------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------
M
L
R
L
-
Q
F
HKKLPF---HDL
N
I
D
Y
TFE---K-P---
V
T
A
M
MGASGS
G
K
S
T
L
F
Q
C
V
S
G
L
K
SIDG
G
I
I
EFDGTPWDDS
N
I
S
L
H
L
PVT
E
R
-
K
V
G
Y
L
F
Q
--
N
L
-ALFPNM
N
V
Y
E
NIAF
G
-
L
----
K
V
K
K
K
K
K
K
-----
E
Q
A
E
I
Q
Q
Q
V
R
K
M
S
D
Y
L
Q
-
I
S
-
H
L
L
Y
S
S
V
Q
---
K
LSGG
E
K
Q
R
V
A
M
A
R
A
MITEP
K
L
L
L
LDEPFNGL
D
E
E
T
R
-------
L
I
C
M
K
L
V
G
Q
M
A
KDFHI
P
V
I
F
V
THYA
S
E
A
E
M
M
T
E
E
I
L
V
M
REGRLEKRKS--------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
89.86
40%
-108
- C1 -
2IT1
-
?
A:
[4-216]
----------
I
K
L
E
N
I
V
K
K
F
G
N
FT-
A
L
N
N
I
N
L
K
I
K
---
D
G
E
---
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
T
E
L
------
P
P
K
D
R
-
N
V
G
L
V
F
Q
--
N
W
-
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
-
L
----
E
L
R
K
A
--------
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
-
I
D
-
K
L
L
N
R
Y
P
W
---
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
-------
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
---------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
86.87
34%
-114
- C1 -
3RLF
3
MALK_ECOLI
A:
[3-217]
---------
S
V
Q
L
Q
N
V
T
K
A
W
G
E
VV-
V
S
K
D
I
N
L
D
I
H
---
E
G
E
---
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
-
G
V
G
M
V
F
Q
--
S
Y
-
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
----
K
L
A
G
A
--------
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
-
H
L
L
D
R
K
P
K
---
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
-------
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
--------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
85.66
36%
-123
- C1 -
2ONK
2
WTPC_ARCFU
F:
[3-205]
----------
L
K
V
-
R
A
E
K
R
L
G
N
---
F
R
L
N
V
D
F
E
M
G
---
R
-
D
---
Y
C
V
L
L
G
P
T
G
A
G
K
S
V
F
L
E
L
I
A
G
I
V
K
P
D
R
G
E
V
R
L
N
G
-----
A
D
I
T
-
P
L
P
P
E
R
R
-
G
I
G
F
V
P
Q
--
D
Y
-
A
L
F
P
H
L
S
V
Y
R
N
I
A
Y
G
-
L
----
R
-----
N
V
-----
E
R
V
E
R
D
R
R
V
R
E
M
A
E
K
L
G
-
I
A
-
H
L
L
D
R
K
P
A
---
R
L
S
G
G
E
R
Q
R
V
A
L
A
R
A
L
V
I
Q
P
R
L
L
L
L
D
E
P
L
S
A
V
D
L
K
T
K
-------
G
V
L
M
E
E
L
R
F
V
Q
R
E
F
D
V
P
I
L
H
V
T
H
D
L
I
E
A
A
M
L
A
D
E
V
A
V
M
L
N
G
R
I
-------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.86
36%
-122
- C1 -
2ONK
2
WTPC_ARCFU
B:
[3-205]
----------
L
K
V
-
R
A
E
K
R
L
G
N
---
F
R
L
N
V
D
F
E
M
G
---
R
-
D
---
Y
C
V
L
L
G
P
T
G
A
G
K
S
V
F
L
E
L
I
A
G
I
V
K
P
D
R
G
E
V
R
L
N
G
-----
A
D
I
T
-
P
L
P
P
E
R
R
-
G
I
G
F
V
P
Q
--
D
Y
-
A
L
F
P
H
L
S
V
Y
R
N
I
A
Y
G
-
L
----
R
-----
N
V
-----
E
R
V
E
R
D
R
R
V
R
E
M
A
E
K
L
G
-
I
A
-
H
L
L
D
R
K
P
A
---
R
L
S
G
G
E
R
Q
R
V
A
L
A
R
A
L
V
I
Q
P
R
L
L
L
L
D
E
P
L
S
A
V
D
L
K
T
K
-------
G
V
L
M
E
E
L
R
F
V
Q
R
E
F
D
V
P
I
L
H
V
T
H
D
L
I
E
A
A
M
L
A
D
E
V
A
V
M
L
N
G
R
I
-------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
84.83
36%
-115
- C1 -
3PUY
3
MALK_ECOLI
A:
[21-214]
--------------------------
D
I
N
L
D
-
I
H
E
---
G
-
E
---
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
-
G
V
G
M
V
F
Q
--
S
Y
-
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
----
K
L
A
G
A
K
K
E
-----
V
---
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
-
H
L
L
D
R
K
P
K
---
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
-------
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-----------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
84.81
36%
-121
- C1 -
3PUX
5
MALK_ECOLI
A:
[21-214]
--------------------------
D
I
N
L
D
-
I
H
E
---
G
-
E
---
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
-
G
V
G
M
V
F
Q
--
S
Y
-
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
----
K
L
A
G
A
K
K
E
-----
V
---
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
-
H
L
L
D
R
K
P
K
---
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
-------
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-----------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
84.69
36%
-109
- C1 -
1V43
-
?
A:
[12-232]
---------
E
V
K
L
E
N
L
T
K
R
F
G
N
FT-
A
V
N
K
L
N
L
T
I
K
---
D
G
E
---
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
L
------
P
P
K
D
R
-
N
I
S
M
V
F
Q
---------
H
M
T
V
Y
E
N
I
A
F
P
-
L
------
K
K
F
--------
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
-
I
E
-
E
L
L
N
R
Y
P
A
---
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
-------
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
--------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
84.61
36%
-118
- C1 -
3PUZ
2
MALK_ECOLI
B:
[21-214]
--------------------------
D
I
N
L
D
-
I
H
E
---
G
-
E
---
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
-
G
V
G
M
V
F
Q
--
S
Y
-
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
----
K
L
A
G
A
K
K
E
-----
V
---
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
-
H
L
L
D
R
K
P
K
---
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
-------
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-----------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
84.47
36%
-100
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-227]
---------
A
L
H
I
G
H
L
S
K
S
F
Q
N
TP-
V
L
N
D
I
S
L
S
L
D
---
P
G
E
---
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
--
N
L
P
V
R
E
R
-
R
L
G
Y
L
V
Q
--
E
G
-
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
----
G
N
G
K
G
--------
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
-
I
S
-
E
L
A
G
R
Y
P
H
---
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
-------
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
--------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.45
36%
-119
- C1 -
2ONK
2
WTPC_ARCFU
A:
[3-205]
----------
L
K
V
-
R
A
E
K
R
L
G
N
---
F
R
L
N
V
D
F
E
M
G
---
R
-
D
---
Y
C
V
L
L
G
P
T
G
A
G
K
S
V
F
L
E
L
I
A
G
I
V
K
P
D
R
G
E
V
R
L
N
G
-----
A
D
I
T
-
P
L
P
P
E
R
R
-
G
I
G
F
V
P
Q
--
D
Y
-
A
L
F
P
H
L
S
V
Y
R
N
I
A
Y
G
-
L
----
R
-----
N
V
-----
E
R
V
E
R
D
R
R
V
R
E
M
A
E
K
L
G
-
I
A
-
H
L
L
D
R
K
P
A
---
R
L
S
G
G
E
R
Q
R
V
A
L
A
R
A
L
V
I
Q
P
R
L
L
L
L
D
E
P
L
S
A
V
D
L
K
T
K
-------
G
V
L
M
E
E
L
R
F
V
Q
R
E
F
D
V
P
I
L
H
V
T
H
D
L
I
E
A
A
M
L
A
D
E
V
A
V
M
L
N
G
R
I
-------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
84.37
36%
-117
- C1 -
3PUV
5
MALK_ECOLI
A:
[21-214]
--------------------------
D
I
N
L
D
-
I
H
E
---
G
-
E
---
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
-
G
V
G
M
V
F
Q
--
S
Y
-
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
----
K
L
A
G
A
K
K
E
-----
V
---
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
-
H
L
L
D
R
K
P
K
---
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
-------
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-----------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
84.08
36%
-116
- C1 -
3PUW
5
MALK_ECOLI
A:
[21-214]
--------------------------
D
I
N
L
D
-
I
H
E
---
G
-
E
---
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
-
G
V
G
M
V
F
Q
--
S
Y
-
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
----
K
L
A
G
A
K
K
E
-----
V
---
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
-
H
L
L
D
R
K
P
K
---
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
-------
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-----------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
84.06
36%
-116
- C1 -
4KI0
4
?
A:
[21-214]
--------------------------
D
I
N
L
D
-
I
H
E
---
G
-
E
---
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
-
G
V
G
M
V
F
Q
--
S
Y
-
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
----
K
L
A
G
A
K
K
E
-----
V
---
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
-
H
L
L
D
R
K
P
K
---
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
-------
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-----------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
84.04
32%
-107
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[7-227]
---------
I
L
K
V
E
E
L
N
Y
N
Y
S
D
GTH
A
L
K
G
I
N
M
N
I
K
---
R
G
E
---
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
D
Y
S
R
K
--
G
I
M
K
L
R
E
-
S
I
G
I
V
F
Q
--
D
P
D
N
Q
L
F
S
A
S
V
Y
Q
D
V
S
F
G
-
A
----
V
N
M
K
L
--------
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
G
-
I
E
-
H
L
K
D
K
P
T
H
---
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
-------
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
--------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.76
36%
-114
- C1 -
3PUZ
2
MALK_ECOLI
A:
[21-214]
--------------------------
D
I
N
L
D
-
I
H
E
---
G
-
E
---
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
-
G
V
G
M
V
F
Q
--
S
Y
-
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
----
K
L
A
G
A
K
K
E
-----
V
---
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
-
H
L
L
D
R
K
P
K
---
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
-------
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-----------------------------------------------------------------------------------------------------------------------------------
108
Fugue
83.60
32%
-109
- C1 -
1OXS
23
?
C:
[1-352]
MVRIIVKNV
S
K
V
F
-
K
K
G
K
V
V
A
L
---
D
N
V
N
I
N
I
E
-
N
---
G
-
E
---
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
S
N
G
-
K
L
I
V
P
P
E
D
R
-
K
I
G
M
V
F
Q
--
T
W
-
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
-
L
----
T
N
M
K
M
S
--------
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
-
I
H
-
H
V
L
N
H
F
P
R
---
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
-------
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
PEDLYDNPVSIQVASLIGEINELEGKVTNEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
34
PsiBlast_CBE
83.55
36%
-109
- C1 -
2AWO
2
MALK_ECOLI
B:
[21-214]
--------------------------
D
I
N
L
D
-
I
H
E
---
G
-
E
---
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
-
G
V
G
M
V
F
Q
--
S
Y
-
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
----
K
L
A
G
A
K
K
E
-----
V
---
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
-
H
L
L
D
R
K
P
K
---
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
-------
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-----------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
83.47
36%
-120
- C1 -
2AWN
2
MALK_ECOLI
B:
[21-214]
--------------------------
D
I
N
L
D
-
I
H
E
---
G
-
E
---
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
-
G
V
G
M
V
F
Q
--
S
Y
-
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
----
K
L
A
G
A
K
K
E
-----
V
---
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
-
L
A
-
H
L
L
D
R
K
P
K
---
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
-------
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-----------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.22
36%
-115
- C1 -
4TQU
-
?
S:
[13-215]
--------------
R
Y
D
K
T
T
V
V
---
H
G
V
S
L
D
I
E
P
G
---
E
-
F
---
V
V
-
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
N
D
------
L
A
P
K
D
R
-
D
V
A
M
V
F
Q
--
N
Y
-
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
-
L
----
R
L
K
R
T
K
K
--------
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
-
L
Q
-
P
L
L
E
R
K
P
S
---
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
-------
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
-----------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.96
36%
-123
- C1 -
2ONK
2
WTPC_ARCFU
G:
[3-205]
----------
L
K
V
-
R
A
E
K
R
L
G
N
---
F
R
L
N
V
D
F
E
M
G
---
R
-
D
---
Y
C
V
L
L
G
P
T
G
A
G
K
S
V
F
L
E
L
I
A
G
I
V
K
P
D
R
G
E
V
R
L
N
G
-----
A
D
I
T
-
P
L
P
P
E
R
R
-
G
I
G
F
V
P
Q
--
D
Y
-
A
L
F
P
H
L
S
V
Y
R
N
I
A
Y
G
-
L
----
R
-----
N
V
-----
E
R
V
E
R
D
R
R
V
R
E
M
A
E
K
L
G
-
I
A
-
H
L
L
D
R
K
P
A
---
R
L
S
G
G
E
R
Q
R
V
A
L
A
R
A
L
V
I
Q
P
R
L
L
L
L
D
E
P
L
S
A
V
D
L
K
T
K
-------
G
V
L
M
E
E
L
R
F
V
Q
R
E
F
D
V
P
I
L
H
V
T
H
D
L
I
E
A
A
M
L
A
D
E
V
A
V
M
L
N
G
R
I
-------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.67
39%
-123
- C1 -
1VCI
1
?
A:
[42-227]
----------------------------------------------
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
-----
D
R
D
V
T
-
Y
L
P
P
K
D
R
-
N
I
S
M
V
F
Q
---------
H
M
T
V
Y
E
N
I
A
F
P
-
L
------
K
K
F
P
K
D
-----
E
---
I
D
K
R
V
R
W
A
A
E
L
L
Q
-
I
E
-
E
L
L
N
R
Y
P
A
---
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
-------
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
-------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
71.33
31%
-103
* C1 *
4MKI
4
ECFA2_CALS4
B:
[27-227]
---------------------
L
---
K
D
I
N
F
S
I
D
D
E
---
E
-
F
---
V
-
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
K
K
V
S
L
K
--
D
I
R
K
-
Q
V
G
L
V
F
Q
YP
E
Y
-
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
--------
P
S
N
L
G
L
-----
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
-
I
S
K
E
L
A
D
K
S
P
F
---
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
-------
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
70.79
31%
-101
- C1 -
4MKI
4
ECFA2_CALS4
A:
[27-227]
---------------------
L
---
K
D
I
N
F
S
I
D
D
E
---
E
-
F
---
V
-
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
K
K
V
S
L
K
--
D
I
R
K
-
Q
V
G
L
V
F
Q
YP
E
Y
-
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
--------
P
S
N
L
G
L
-----
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
-
I
S
K
E
L
A
D
K
S
P
F
---
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
-------
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
69.75
34%
-106
- C1 -
4YMU
2
?
A:
[29-212]
--------------------------------------------
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
I
N
K
--
V
R
Q
-
K
V
G
M
V
F
Q
--
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
----
K
V
K
K
M
N
K
K
-----
E
A
E
E
L
A
------
V
D
L
L
A
-
K
V
-
G
L
L
D
K
K
D
Q
YPI
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
---------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
68.94
33%
-96
- C1 -
3C4J
4
?
B:
[49-235]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
A
K
A
M
--
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
68.89
34%
-101
- C1 -
4YMV
1
?
A:
[29-212]
--------------------------------------------
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
I
N
K
--
V
R
Q
-
K
V
G
M
V
F
Q
--
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
----
K
V
K
K
M
N
K
K
-----
E
A
E
E
L
A
------
V
D
L
L
A
-
K
V
-
G
L
L
D
K
K
D
Q
YPI
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
---------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
68.72
34%
-107
- C1 -
4YMV
1
?
J:
[29-212]
--------------------------------------------
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
I
N
K
--
V
R
Q
-
K
V
G
M
V
F
Q
--
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
----
K
V
K
K
M
N
K
K
-----
E
A
E
E
L
A
------
V
D
L
L
A
-
K
V
-
G
L
L
D
K
K
D
Q
YPI
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
---------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
68.70
34%
-106
- C1 -
4YMU
2
?
J:
[29-212]
--------------------------------------------
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
I
N
K
--
V
R
Q
-
K
V
G
M
V
F
Q
--
H
F
-
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
----
K
V
K
K
M
N
K
K
-----
E
A
E
E
L
A
------
V
D
L
L
A
-
K
V
-
G
L
L
D
K
K
D
Q
YPI
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
---------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
68.69
33%
-90
- C1 -
3C41
3
?
J:
[28-214]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
--
A
K
A
M
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
68.27
33%
-93
- C1 -
2OLJ
4
?
A:
[49-235]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
A
K
A
M
--
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
68.21
33%
-91
- C1 -
2OLK
1
?
D:
[49-235]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
A
K
A
M
--
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
66.98
33%
-91
- C1 -
2OLK
2
?
B:
[49-235]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
A
K
A
M
--
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
66.79
33%
-82
- C1 -
2OLJ
3
?
B:
[49-235]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
A
K
A
M
--
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
66.78
33%
-89
- C1 -
2Q0H
4
?
A:
[49-235]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
A
K
A
M
--
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
66.11
33%
-88
- C1 -
2Q0H
4
?
B:
[49-235]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
A
K
A
M
--
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
66.08
33%
-84
- C1 -
2OLK
1
?
C:
[49-235]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
A
K
A
M
--
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
66.02
37%
-83
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[35-227]
-----------------------------------------------
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
--
N
L
P
V
R
E
R
-
R
L
G
Y
L
V
Q
--
E
G
-
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
----
G
N
G
K
G
R
T
A
-----
Q
E
---
R
Q
R
I
E
A
M
L
E
L
T
G
-
I
S
-
E
L
A
G
R
Y
P
H
---
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
-------
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
--------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
65.86
37%
-78
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[35-222]
-----------------------------------------------
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
--
N
L
P
V
R
E
R
-
R
L
G
Y
L
V
Q
--
E
G
-
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
----
G
N
G
K
G
R
T
A
-----
Q
E
---
R
Q
R
I
E
A
M
L
E
L
T
G
-
I
S
-
E
L
A
G
R
Y
P
H
---
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
RQIREDM
I
A
A
L
R
A
N
G
K
S
A
-------
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
--------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
65.60
33%
-86
- C1 -
3C4J
3
?
A:
[49-235]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
A
K
A
M
--
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
65.07
33%
-85
- C1 -
2OLK
1
?
A:
[49-235]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
A
K
A
M
--
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
65.02
33%
-93
- C1 -
3C41
3
?
K:
[28-214]
----------------------------------
E
---
G
-
E
---
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
--
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
-
P
----
M
K
V
R
K
W
P
R
-----
E
K
A
E
--
A
K
A
M
E
L
L
D
K
V
G
-
L
K
-
D
K
A
H
A
Y
P
D
---
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
---------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
61.61
31%
-98
- C1 -
4U00
3
?
A:
[34-216]
----------------------------------------------
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
A
---
L
R
E
I
R
R
-
E
V
G
M
V
F
Q
--
Q
F
-
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
-
P
----
M
R
V
R
R
W
P
R
-----
E
K
A
E
-----
K
K
A
L
E
L
L
E
-
R
V
-
G
I
L
D
Q
A
R
K
YPA
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
-------
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
-------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
60.15
31%
-92
- C1 -
4P33
6
LPTB_ECOLI
B:
[30-214]
--------------------------------------------
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
--
N
I
I
I
D
D
D
D
I
S
L
L
P
L
H
-
A
R
A
R
R
-
G
I
G
Y
L
P
Q
--
E
A
-
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
-
L
----
Q
I
R
D
D
L
S
A
-----
E
Q
R
E
--
D
R
A
N
E
L
M
E
E
F
H
-
I
E
-
H
L
R
D
S
M
G
Q
---
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
-
P
I
S
-------
V
I
D
I
K
R
I
I
E
H
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
-------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
58.84
31%
-95
- C1 -
4P33
7
LPTB_ECOLI
A:
[30-214]
--------------------------------------------
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
--
N
I
I
I
D
D
D
D
I
S
L
L
P
L
H
-
A
R
A
R
R
-
G
I
G
Y
L
P
Q
--
E
A
-
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
-
L
----
Q
I
R
D
D
L
S
A
-----
E
Q
R
E
--
D
R
A
N
E
L
M
E
E
F
H
-
I
E
-
H
L
R
D
S
M
G
Q
---
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
-
P
I
S
-------
V
I
D
I
K
R
I
I
E
H
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
-------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
47.02
32%
-83
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[393-569]
------------------------------
D
F
S
L
S
---
I
-
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
-----
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
-
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
-
A
DDPS
S
V
T
A
E
E
I
Q
-----
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
-
T
V
V
G
E
K
G
V
---
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
-------
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
45.96
32%
-79
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[362-538]
------------------------------
D
F
S
L
S
---
I
-
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
-----
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
-
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
-
A
DDPS
S
V
T
A
E
E
I
Q
-----
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
-
T
V
V
G
E
K
G
V
---
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
-------
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
45.87
32%
-74
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[362-538]
------------------------------
D
F
S
L
S
---
I
-
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
-----
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
-
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
-
A
DDPS
S
V
T
A
E
E
I
Q
-----
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
-
T
V
V
G
E
K
G
V
---
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
-------
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
40.04
31%
-86
- C1 -
1MV5
1
LMRA_LACLA
C:
[20-187]
------------------------------
D
I
S
F
E
AQP
N
-
S
---
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
I
D
--
N
I
S
L
E
--
N
W
R
S
-
Q
I
G
F
V
S
Q
--
D
S
-
A
I
M
A
G
-
T
I
R
E
N
L
T
Y
G
-
L
----
E
G
D
Y
T
D
E
D
LWQVL
D
L
A
F
A
R
S
F
V
E
N
M
P
D
--
Q
-
L
N
-
T
E
V
G
E
R
G
V
---
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
-------
S
M
V
Q
K
A
L
D
S
L
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
36.59
31%
-74
- C1 -
1MV5
2
D:
[20-187]
------------------------------
D
I
S
F
E
AQP
N
-
S
---
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
I
D
--
N
I
S
L
E
--
N
W
R
S
-
Q
I
G
F
V
S
Q
--
D
S
-
A
I
M
A
G
-
T
I
R
E
N
L
T
Y
G
-
L
----
E
G
D
Y
T
D
E
D
LWQVL
D
L
A
F
A
R
S
F
V
E
N
M
P
D
--
Q
-
L
N
-
T
E
V
G
E
R
G
V
---
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
-------
S
M
V
Q
K
A
L
D
S
L
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
35.12
31%
-77
- C1 -
1MV5
2
LMRA_LACLA
A:
[20-187]
------------------------------
D
I
S
F
E
A
Q
P
N
-
S
---
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
I
D
--
N
I
S
L
E
--
N
W
R
S
-
Q
I
G
F
V
S
Q
--
D
S
-
A
I
M
A
G
-
T
I
R
E
N
L
T
Y
G
-
L
----
E
G
D
Y
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
--
Q
-
L
N
-
T
E
V
G
E
R
G
V
---
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
-------
S
M
V
Q
K
A
L
D
S
L
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
34.97
31%
-55
- C1 -
1MV5
1
LMRA_LACLA
B:
[20-187]
------------------------------
D
I
S
F
E
AQP
N
-
S
---
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
I
D
--
N
I
S
L
E
--
N
W
R
S
-
Q
I
G
F
V
S
Q
--
D
S
-
A
I
M
A
G
-
T
I
R
E
N
L
T
Y
G
-
L
----
E
G
D
Y
T
D
E
D
LWQVL
D
L
A
F
A
R
S
F
V
E
N
M
P
D
--
Q
-
L
N
-
T
E
V
G
E
R
G
V
---
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
-------
S
M
V
Q
K
A
L
D
S
L
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------