@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1055: (2016-03-21 )
MVVGDFPEERDTIVIGAGPGGYVAAIRAAQLGQKVTIIEKEYYGGVCLNVGCIPSKALITIGHRFKEAGHSDNMGITADNVNLDFTKAQEWKGGVVNKLTSGVKGLLKKNKVEMLEGEAFFVDDHSLRVIHPDSAQTYTFNNVIIATGSRPIEIPGFKYGKRVLSSTGALALTEVPKKLVVIGGGYIGTELGGAFANLGTELTILEGGPEILPTYEKDMVSLVKRNLKSKNVEMVTKALAKSAEETENGVKVTYEANGETKTIEADYVLVTVGRRPNTDEIGLEQAGVKVTERGLVEVDKQGRSNVSNIFAIGDIVPGVPLAHKASYEAKIAAEAIAGEKSENDYTALPAVVFSDPELATVGLTEKEAKEKGFDVKAAKFPFGGNGRALSLDAPEGFVRLVTRKEDGLVIGAQVAGMNASDIISEIGLAIESGITAEDIALTIHAHPSLGELTMEAAELALGRPIHM
Atome Classification :
(53 SA)
.........10........20........30........40------.-------.-------.......50........60--...--......-70--.-.---..-....-.-80........90........100-.......-110........120..---------.....------130-----------.-------.-.-.-------.-----..140.......150--...-....-160---.------..-.-.....170.-.-.....180.......190.....-..200.......210...-....220....--...-230.........240.......--250..-.--.---.-.---.260.--........270.......280.......290.......300.......310......-.-320........330.......340.--..--......------350.......360.......370...-....380.......390....----...400.......410.....-..420.......430.......440.....---..450.......460.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVVGDFPEER
D
T
I
V
I
GAGPG
G
Y
V
A
A
I
R
A
A
QLG
Q
K
V
T
I
I
E
K-------E-------Y-------YG
G
V
C
L
NVGCIP
S
K
A
L
I
T
---
I
G
H
--
R
F
K
EAG-H---S-D---NM-
G
I
T
A-D-N
V
N
L
D
F
T
K
A
Q
E
WKG
G
V
V
N
K
L
T
S
G
-
V
K
G
L
L
K
K-NK-
V
E
MLEG
E
A
F
F
VDD---------H
S
L
R
V
------IHP-----------D-------S-A-
Q
-------
T
-----
Y
T
FN
N
V
I
I
ATGSR
P
I
--EIP-
G
F
K
Y
-
G
-----
K
------
R
V
-
L
-SSTG
A
L
A
L
T
-E-VP
K
K
L
V
V
IGGG
Y
I
G
T
E
L
G
G
A
F
A
N-LG
T
E
L
T
I
LEGGPEILP
T
Y
-
E
K
D
M
V
S
L
V
K
R
N--LKS-K--
N
V
E
M
V
T
K
A
L
A
K
S
A
E
ETEN
G
--
V
K
V
T
Y
-E--A---N-G---ET--
K
--
T
I
EA
D
Y
V
L
V
TVGRRPNTDEIG
L
E
QAG
V
K
VTER
G
L
V
E
VDKQGRSNVS
N
I
F
A
IGDIVPG-V-P-LAHKASY
E
A
K
I
A
A
E
A
IAGEK--S--EN--DYTAL
P
------
A
V
V
FSDP
E
L
A
T
VGL
T
E
K
E
A
KEKGFDV-K
A
A
KFPFGGNG
R
A
L
S
LDAP
E
G
----
F
V
R
L
VTRKED
G
L
V
I
G
A
Q
VAGM-
N
A
S
D
I
I
S
E
I
G
L
A
I
ESGI
T
A
E
D
I
A
L
T
I
HAHP---S
L
G
E
L
T
M
E
A
A
E
L
ALGRPIHM
21
PsiBlast_CBE
96.32
70%
-97
- C1 -
1EBD
2
DLDH1_GEOSE
B:
[3-455]
--------
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
-------
N
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
---
A
S
H
--
R
Y
E
Q
A
K
-
H
---
S
-
E
---
E
M
-
G
I
K
A
-
E
-
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
G
-
N
K
-
V
E
I
V
K
G
E
A
Y
F
V
D
A
---------
N
T
V
R
V
------
V
N
G
-----------
D
-------
S
-
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
-
N
F
K
F
-
S
-----
N
------
R
I
-
L
-
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
-
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
I
I
K
K
R
--
L
K
K
-
K
--
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
E
D
G
--
V
T
V
T
Y
-
E
--
A
---
N
-
G
---
E
T
--
K
--
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
-
P
-
A
-
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
--
S
--
A
V
--
D
Y
V
A
I
P
------
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
-
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
-
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
G
E
I
A
M
E
A
A
E
V
A
L
------
1
PsiBlast_PDB
95.61
70%
-98
- C1 -
1EBD
2
DLDH1_GEOSE
A:
[3-455]
--------
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
-------
N
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
---
A
S
H
--
R
Y
E
Q
A
K
-
H
---
S
-
E
---
E
M
-
G
I
K
A
-
E
-
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
G
-
N
K
-
V
E
I
V
K
G
E
A
Y
F
V
D
A
---------
N
T
V
R
V
------
V
N
G
-----------
D
-------
S
-
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
-
N
F
K
F
-
S
-----
N
------
R
I
-
L
-
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
-
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
I
I
K
K
R
--
L
K
K
-
K
--
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
E
D
G
--
V
T
V
T
Y
-
E
--
A
---
N
-
G
---
E
T
--
K
--
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
-
P
-
A
-
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
--
S
--
A
V
--
D
Y
V
A
I
P
------
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
-
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
-
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
G
E
I
A
M
E
A
A
E
V
A
L
------
122
HHSearch
95.29
70%
-96
- C1 -
1EBD
2
DLDH1_GEOSE
A:
[2-455]
-------
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
-------
N
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
---
A
S
H
--
R
Y
E
Q
A
K
-
H
---
S
-
E
---
E
M
-
G
I
K
A
-
E
-
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
G
-
N
K
-
V
E
I
V
K
G
E
A
Y
F
V
D
A
---------
N
T
V
R
V
------
V
N
G
-----------
D
-------
S
-
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
-
N
F
K
F
-
S
-----
N
------
R
I
-
L
-
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
-
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
I
I
K
K
R
--
L
K
K
-
K
--
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
E
D
G
--
V
T
V
T
Y
-
E
--
A
---
N
-
G
---
E
T
--
K
--
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
-
P
-
A
-
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
--
S
--
A
V
--
D
Y
V
A
I
P
------
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
-
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
-
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
G
E
I
A
M
E
A
A
E
V
A
L
------
22
PsiBlast_CBE
85.50
43%
-92
- C1 -
4JQ9
19
?
F:
[10-458]
------------
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
Y------
N
-------
T
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
V
A
K
--
V
I
E
E
A
K
-
A
---
L
-
A
---
E
H
-
G
I
V
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
G
-
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
A
---------
N
T
L
E
V
------
E
G
E
-----------
N
-------
G
-
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
-
F
I
P
H
E
D
-----
P
------
R
I
-
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
-
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
-
D
K
D
I
V
K
V
F
T
K
R
--
I
-
S
-
K
--
K
F
N
L
M
L
E
T
K
V
T
A
V
E
A
K
E
D
G
--
I
Y
V
T
M
-
E
--
G
---
K
K
A
---
P
A
--
E
--
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
Q
-
P
-
M
-
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
--
H
--
Y
F
--
D
P
K
V
I
P
------
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
-
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
----
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
-
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
S
V
G
L
A
A
E
V
--------
26
PsiBlast_CBE
84.18
43%
-92
- C1 -
4JQ9
10
?
B:
[10-458]
------------
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
Y------
N
-------
T
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
V
A
K
--
V
I
E
E
A
K
-
A
---
L
-
A
---
E
H
-
G
I
V
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
G
-
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
A
---------
N
T
L
E
V
------
E
G
E
-----------
N
-------
G
-
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
-
F
I
P
H
E
D
-----
P
------
R
I
-
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
-
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
-
D
K
D
I
V
K
V
F
T
K
R
--
I
-
S
-
K
--
K
F
N
L
M
L
E
T
K
V
T
A
V
E
A
K
E
D
G
--
I
Y
V
T
M
-
E
--
G
---
K
K
A
---
P
A
--
E
--
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
Q
-
P
-
M
-
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
--
H
--
Y
F
--
D
P
K
V
I
P
------
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
-
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
----
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
-
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
S
V
G
L
A
A
E
V
--------
34
PsiBlast_CBE
83.79
45%
-86
- C1 -
2EQ9
2
?
G:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------------
G
-
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
-
G
F
P
F
-
G
-----
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
PA
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
13
PsiBlast_PDB
83.55
41%
-89
- C1 -
3URH
3
?
A:
[27-486]
----------
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
-------
R
-------
S
T------
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
A
S
E
--
M
F
H
Q
A
Q
-
H
---
G
L
E
---
A
L
-
G
V
E
V
-
A
-
N
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
-
V
S
F
L
F
K
K
-
N
K
-
I
D
G
F
Q
G
T
G
K
V
L
G
Q
---------
G
K
V
S
V
------
T
N
E
-----------
K
-------
G
-
E
E
Q
-------
V
-----
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
--
G
I
P
-
G
V
E
V
-
A
F
DE--
K
------
T
I
-
V
-
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
-
D
G
E
V
A
K
Q
L
Q
R
M
--
L
T
K
-
Q
--
G
I
D
F
K
L
G
A
K
V
T
G
A
V
K
S
G
D
G
--
A
K
V
T
F
-
E
PV
K
---
G
-
G
---
E
A
--
T
--
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
G
-
P
-
M
-
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
--
G
--
H
V
--
N
Y
D
V
I
P
------
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
-
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
----
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
-
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
---
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
-----
31
PsiBlast_CBE
83.51
45%
-87
- C1 -
2EQ9
2
?
K:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------------
G
-
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
-
G
F
P
F
-
G
-----
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
PA
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
6
PsiBlast_PDB
83.44
45%
-86
- C1 -
2EQ8
2
?
A:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------------
G
-
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
-
G
F
P
F
-
G
-----
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
P
A
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
33
PsiBlast_CBE
83.30
45%
-89
- C1 -
2EQ9
2
?
H:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------------
G
-
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
-
G
F
P
F
-
G
-----
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
PA
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
41
PsiBlast_CBE
83.28
45%
-85
- C1 -
2EQ6
2
?
B:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------------
G
-
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
-
G
F
P
F
-
G
-----
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
PA
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
7
PsiBlast_PDB
83.28
45%
-89
- C1 -
2EQ9
2
?
A:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------------
G
-
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
-
G
F
P
F
-
G
-----
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
P
A
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
37
PsiBlast_CBE
83.13
45%
-87
- C1 -
2EQ9
2
?
B:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------------
G
-
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
-
G
F
P
F
-
G
-----
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
PA
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
40
PsiBlast_CBE
82.85
45%
-85
- C1 -
2EQ8
2
?
B:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------------
G
-
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
-
G
F
P
F
-
G
-----
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
PA
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
38
PsiBlast_CBE
82.80
45%
-86
- C1 -
2EQ8
2
?
E:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------------
G
-
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
-
G
F
P
F
-
G
-----
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
PA
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
2
PsiBlast_PDB
82.79
43%
-90
- C1 -
4JDR
9
DLDH_ECOLI
A:
[10-458]
------------
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
Y------
N
-------
T
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
V
A
K
--
V
I
E
E
A
K
-
A
---
L
-
A
---
E
H
-
G
I
V
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
G
-
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
A
---------
N
T
L
E
V
------
E
G
E
-----------
N
-------
G
-
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
-
F
I
P
H
E
D
-----
P
------
R
I
-
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
-
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
-
D
K
D
I
V
K
V
F
T
K
R
--
I
-
S
-
K
--
K
F
N
L
M
L
E
T
K
V
T
A
V
E
A
K
E
D
G
--
I
Y
V
T
M
-
E
--
G
---
K
K
A
---
P
A
--
E
--
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
Q
-
P
-
M
-
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
--
H
--
Y
F
--
D
P
K
V
I
P
------
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
-
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
----
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
-
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
S
V
G
L
A
A
E
V
--------
27
PsiBlast_CBE
82.60
43%
-89
- C1 -
4JDR
5
DLDH_ECOLI
B:
[10-458]
------------
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
Y------
N
-------
T
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
V
A
K
--
V
I
E
E
A
K
-
A
---
L
-
A
---
E
H
-
G
I
V
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
G
-
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
A
---------
N
T
L
E
V
------
E
G
E
-----------
N
-------
G
-
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
-
F
I
P
H
E
D
-----
P
------
R
I
-
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
-
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
-
D
K
D
I
V
K
V
F
T
K
R
--
I
-
S
-
K
--
K
F
N
L
M
L
E
T
K
V
T
A
V
E
A
K
E
D
G
--
I
Y
V
T
M
-
E
--
G
---
K
K
A
---
P
A
--
E
--
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
Q
-
P
-
M
-
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
--
H
--
Y
F
--
D
P
K
V
I
P
------
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
-
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
----
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
-
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
S
V
G
L
A
A
E
V
--------
25
PsiBlast_CBE
82.54
43%
-91
- C1 -
4JQ9
2
?
C:
[10-458]
------------
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
Y------
N
-------
T
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
V
A
K
--
V
I
E
E
A
K
-
A
---
L
-
A
---
E
H
-
G
I
V
F
-
G
-
E
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
-
L
A
G
M
A
K
G
-
R
K
-
V
K
V
V
N
G
L
G
K
F
T
G
A
---------
N
T
L
E
V
------
E
G
E
-----------
N
-------
G
-
K
-
T
-------
V
-----
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
--
Q
L
P
-
F
I
P
H
E
D
-----
P
------
R
I
-
W
-
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
-
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
-
D
K
D
I
V
K
V
F
T
K
R
--
I
-
S
-
K
--
K
F
N
L
M
L
E
T
K
V
T
A
V
E
A
K
E
D
G
--
I
Y
V
T
M
-
E
--
G
---
K
K
A
---
P
A
--
E
--
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
Q
-
P
-
M
-
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
--
H
--
Y
F
--
D
P
K
V
I
P
------
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
-
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
----
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
-
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
---
T
L
H
E
S
V
G
L
A
A
E
V
--------
32
PsiBlast_CBE
82.50
45%
-87
- C1 -
2EQ9
2
?
J:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------------
G
-
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
-
G
F
P
F
-
G
-----
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
PA
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
5
PsiBlast_PDB
82.38
45%
-85
- C1 -
2EQ6
2
?
A:
[8-461]
----------
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
-
K
-
P
-
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
----------------------------
G
-
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
-
G
F
P
F
-
G
-----
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
PA
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
Q
-
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
131
Fugue
81.48
61%
-91
- C1 -
1EBD
2
DLDH1_GEOSE
A:
[1-455]
------
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
-------
N
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
---
A
S
H
--
R
Y
E
Q
A
K
-
H
-----
S
EEM
G
I
-
K
A
E
----
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
-
V
E
G
L
L
K
G
N
K
--
V
E
I
V
K
-
G
E
A
Y
F
V
-DAN
T
V
R
V
V
N
-------------
G
-----------
D
-------
S
-
A
-
Q
-------
T
-----
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
--
E
L
P
-
N
F
K
F
-
S
------NRILD
S
T
G
-
A
-
L
N
L
G
------
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
-
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
-F
E
K
Q
M
A
A
I
I
K
K
R
--
L
K
K
-
K
--
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
E
-
D
--
G
V
T
V
T
-
Y
--
E
---
A
-
N
G
E
T
-
K
--
T
--
I
D
-
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
--P
A
-
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
-----------
H
P
S
A
V
D
YV
A
I
P
A
V
V
F
S
D
-
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
-----
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
DTD
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
-P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
PT-
L
G
E
I
A
M
E
A
A
E
V
A
L
------
110
HHSearch
81.21
41%
-86
- C1 -
3URH
3
?
A:
[26-486]
---------
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
R------
S
-------
T
-------
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
A
S
E
--
M
F
H
Q
A
Q
-
H
G--
L
-
E
---
A
L
-
G
V
E
V
-
A
-
N
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
-
V
S
F
L
F
K
K
-
N
K
-
I
D
G
F
Q
G
T
G
K
V
L
G
Q
---------
G
K
V
S
V
------
T
N
E
-----------
K
-------
G
E
E
-
Q
-------
V
-----
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
--
G
---
I
P
G
V
-
E
V
A
F
DE
K
------
T
I
-
V
-
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
-
D
G
E
V
A
K
Q
L
Q
R
M
--
L
T
K
-
Q
--
G
I
D
F
K
L
G
A
K
V
T
G
A
V
K
S
G
D
G
--
A
K
V
T
F
-
E
PV
K
---
G
-
G
---
E
A
--
T
--
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
G
-
P
-
M
-
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
--
G
--
H
V
--
N
Y
D
V
I
P
------
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
-
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
----
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
-
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
---
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
-----
121
HHSearch
81.16
42%
-86
- C1 -
2YQU
4
?
A:
[1-455]
--------
M
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
E------
K
-------
A
-------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
---
T
T
E
--
R
I
Y
E
A
K
-
K
-----
G
---
L
L
-
G
A
K
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
K
-
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
E
---------
R
K
V
L
V
------
E
E
T
---------------------
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
-
W
A
Q
V
-
D
Y----
E
------
R
V
-
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
E
R
V
--
F
K
K
-
Q
--
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
--
A
R
V
E
L
----------
E
---
G
G
--
E
--
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
-
M
-
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
--
G
--
H
V
--
D
Y
Q
A
I
P
------
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
-
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
-
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
113
HHSearch
81.05
38%
-81
- C1 -
1V59
4
DLDH_YEAST
A:
[2-478]
-----
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
R------
G
-------
K
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
---
N
S
H
--
L
F
H
Q
M
H
T
E
---
A
-
Q
---
K
R
-
G
I
D
V
N
G
-
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
-
I
E
L
L
F
K
K
-
N
K
-
V
T
Y
Y
K
G
N
G
S
F
E
D
E
---------
T
K
I
R
V
------
T
P
V
-----------
D
GLEGTVK
E
-
D
-
H
-------
I
-----
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
--
P
F
P
-
G
I
E
I
-
D
E----
E
------
K
I
-
V
-
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
Q
K
F
--
L
K
K
-
Q
--
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
K
N
V
V
E
I
V
V
-
E
--
D
TK-
T
-
N
---
K
Q
--
E
--
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
G
-
P
-
M
-
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
--
G
--
H
V
--
N
Y
N
N
I
P
------
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
-
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
-
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
---
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
C
111
HHSearch
80.82
40%
-84
* C1 *
2QAE
2
DLDH_TRYCR
A:
[2-468]
--------
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
R------
G
-------
A
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
A
T
H
--
L
Y
H
D
A
H
-
A
N--
F
-
A
---
R
Y
-
G
L
M
G
G
E
-
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
-
V
E
Y
L
F
K
K
-
N
K
-
V
T
Y
Y
K
G
E
G
S
F
E
T
A
---------
H
S
I
R
V
------
N
G
L
-----------
D
G------
K
-
Q
-
E
-------
M
-----
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
--
E
L
P
-
F
L
P
F
-
D
-----
E
K-----
V
V
-
L
-
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
A
L
V
G
A
--
L
A
K
N
E
--
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
G
D
S
--
V
S
L
E
V
-
E
G-
K
----------
R
--
E
--
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
P
-
M
-
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
--
G
--
H
V
--
N
Y
G
V
I
P
------
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
-
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
-
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
---
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
F
115
HHSearch
80.75
45%
-81
- C1 -
2EQ6
2
?
A:
[4-460]
------
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
---
A
A
E
--
T
L
H
H
L
K
-
V
---
A
-
E
---
G
F
-
G
L
K
A
---
K
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
-
V
G
T
L
L
K
G
-
N
G
-
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
------
G
-----------------------
G
-
E
-------
R
-----
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
--
E
L
K
G
F
P
F
G
-------
E
------
D
V
-
W
-
D
S
T
R
A
L
K
V
E
E
G
-
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
-
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
R
R
A
--
L
E
K
-
E
--
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
H
V
R
L
-
E
PA
E
---
G
-
G
---
E
G
--
E
--
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
-
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
--
A
F
--
D
Y
-
Q
V
P
------
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
-
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
-
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
---
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
-
45
PsiBlast_CBE
80.08
39%
-83
- C1 -
3LAD
2
DLDH_AZOVI
B:
[2-471]
-------
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
YKGKEGK
T
-------
A
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
---
S
S
Y
--
K
F
H
E
A
H
-
E
---
S
-
F
---
K
L
H
G
I
S
T
-
G
-
E
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
-
V
A
S
L
I
K
A
-
N
G
-
V
T
L
F
E
G
H
G
K
L
L
A
G
---------
K
K
V
E
V
------
T
A
A
-----------
D
G------
S
-
S
-
Q
-------
V
-----
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
--
E
I
P
-
P
A
P
V
-
D
-----
Q
------
D
V
-
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
-
D
E
Q
V
A
K
E
A
Q
K
I
--
L
T
K
-
Q
--
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
N
K
Q
--
V
T
V
K
F
V
D
--
A
---
E
-
G
---
E
---
K
--
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
G
-
A
-
M
-
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
--
A
--
Q
M
--
N
Y
D
L
I
P
------
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
-
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
----
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
-
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
---
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
10
PsiBlast_PDB
79.98
41%
-86
- C1 -
2YQU
4
?
A:
[3-455]
----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-------
E
-------
K
A------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
---
T
T
E
--
R
I
Y
E
A
--
K
---
K
-
G
---
L
L
-
G
A
K
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
K
-
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
E
---------
R
--
K
V
------
L
V
E
-----------
E
-------
T
-
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
-
W
A
Q
V
-
D
Y----
E
------
R
V
-
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
E
R
V
--
F
K
K
-
Q
--
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
--
A
R
V
E
L
-
E
--
G
---
G
---------
E
--
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
-
M
-
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
--
G
--
H
V
--
D
Y
Q
A
I
P
------
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
-
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
-
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
12
PsiBlast_PDB
79.64
39%
-82
- C1 -
3LAD
2
DLDH_AZOVI
A:
[2-471]
-------
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
YKGKEGK
T
-------
A
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
---
S
S
Y
--
K
F
H
E
A
H
-
E
---
S
-
F
---
K
L
H
G
I
S
T
-
G
-
E
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
-
V
A
S
L
I
K
A
-
N
G
-
V
T
L
F
E
G
H
G
K
L
L
A
G
---------
K
K
V
E
V
------
T
A
A
-----------
D
G------
S
-
S
-
Q
-------
V
-----
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
--
E
I
P
-
P
A
P
V
-
D
-----
Q
------
D
V
-
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
-
D
E
Q
V
A
K
E
A
Q
K
I
--
L
T
K
-
Q
--
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
N
K
Q
--
V
T
V
K
F
V
D
--
A
---
E
-
G
---
E
---
K
--
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
G
-
A
-
M
-
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
--
A
--
Q
M
--
N
Y
D
L
I
P
------
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
-
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
----
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
-
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
---
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
42
PsiBlast_CBE
79.49
41%
-85
- C1 -
2YQU
6
?
B:
[3-455]
----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-------
E
-------
K
A------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
---
T
T
E
--
R
I
Y
E
A
--
K
---
K
-
G
---
L
L
-
G
A
K
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
K
-
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
E
---------
R
--
K
V
------
L
V
E
-----------
E
-------
T
-
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
-
W
A
Q
V
-
D
Y----
E
------
R
V
-
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
E
R
V
--
F
K
K
-
Q
--
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
--
A
R
V
E
L
-
E
--
G
---
G
---------
E
--
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
-
M
-
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
--
G
--
H
V
--
D
Y
Q
A
I
P
------
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
-
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
-
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
9
PsiBlast_PDB
79.28
41%
-85
- C1 -
2EQ7
3
?
A:
[3-452]
----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-------
E
-------
K
A------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
---
T
T
E
--
R
I
Y
E
A
--
K
---
K
-
G
---
L
L
-
G
A
K
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
K
-
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
E
---------
R
--
K
V
------
L
V
E
-----------
E
-------
T
-
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
-
W
A
Q
V
-
D
Y----
E
------
R
V
-
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
E
R
V
--
F
K
K
-
Q
--
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
--
A
R
V
E
L
-
E
--
G
---
G
---------
E
--
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
-
M
-
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
--
G
--
H
V
--
D
Y
Q
A
I
P
------
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
-
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
-
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
---
114
HHSearch
79.12
39%
-81
- C1 -
3LAD
2
DLDH_AZOVI
A:
[2-470]
-------
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
-------
Y
KGKEGKT
A
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
---
S
S
Y
--
K
F
H
E
A
H
E
S
---
F
-
K
---
L
H
-
G
I
S
T
-
G
-
E
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
-
V
A
S
L
I
K
A
-
N
G
-
V
T
L
F
E
G
H
G
K
L
L
A
G
---------
K
K
V
E
V
------
T
A
A
-----------
D
-------
G
S
S
-
Q
-------
V
-----
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
--
E
I
P
-
P
A
P
V
-
D
Q----
D
------
V
I
-
V
-
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
-
D
E
Q
V
A
K
E
A
Q
K
I
--
L
T
K
-
Q
--
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
N
K
Q
--
V
T
V
K
F
-
V
--
D
---
A
-
E
---
G
E
--
K
--
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
G
-
A
-
M
-
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
--
A
--
Q
M
--
N
Y
D
L
I
P
------
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
-
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
----
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
-
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
---
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
-
112
HHSearch
79.05
42%
-81
- C1 -
1OJT
1
?
A:
[2-474]
----
S
A
D
A
E
Y
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
Y------
K
-------
T
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
N
A
A
--
V
I
D
E
V
R
-
H
---
L
-
A
---
A
N
-
G
I
K
Y
-
P
-
E
P
E
L
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
G
-
L
A
G
M
A
K
S
-
R
K
-
V
D
V
I
Q
G
D
G
Q
F
L
D
P
---------
H
H
L
E
V
------
S
L
T
A
G
DAYE
Q
A
A
P
T
G
-------
E
-
K
-
K
-------
I
-----
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
--
K
L
P
-
F
I
P
E
-
D
-----
P
------
R
I
-
I
-
D
S
S
G
A
L
A
L
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
-
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
G
A
-
D
R
D
L
V
K
V
W
Q
K
Q
--
N
E
Y
-
R
--
F
D
N
I
M
V
N
T
K
T
V
A
V
E
P
K
E
D
G
--
V
Y
V
T
F
-
E
--
G
A
--
N
-
A
---
P
K
--
E
--
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
G
Q
-
P
-
M
-
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
--
A
--
Y
F
--
D
A
R
V
I
P
------
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
-
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
----
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
-
N
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
---
T
L
G
E
S
I
G
M
A
A
E
V
A
L
G
T
C
---
89
PsiBlast_CBE
78.99
36%
-91
- C1 -
3II4
3
DLDH_MYCTU
B:
[7-466]
----------
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-------
K
-------
Y
-------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
--
I
F
T
K
D
A
-
K
---
A
------
F
-
G
I
S
G
-
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
-
V
H
F
L
M
K
K
-
N
K
-
I
T
E
I
H
G
Y
G
T
F
A
D
A
---------
N
T
L
L
V
D-----
L
N
D
-----------
G
-------
G
-
T
-
E
-------
S
-----
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
--
L
V
P
-
G
T
S
L
-
S
-----
A
------
N
V
-
V
-
T
Y
E
E
Q
I
L
S
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
E
K
Q
--
F
K
K
-
L
--
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
G
S
Q
--
V
T
V
T
V
-
T
--
K
---
D
-
G
---
V
A
--
Q
--
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
-
L
-
Q
-
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
--
T
--
L
T
LG
D
H
R
M
L
P
------
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
-
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
---
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
F
80
PsiBlast_CBE
78.92
37%
-76
- C1 -
1V59
3
DLDH_YEAST
B:
[6-477]
---------
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-------
R
G------
K
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
---
N
S
H
--
L
F
H
Q
M
H
T
E
---
A
-
Q
---
K
R
-
G
I
D
V
-
N
G
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
-
I
E
L
L
F
K
K
-
N
K
-
V
T
Y
Y
K
G
N
G
S
F
E
D
E
---------
T
K
I
R
V
------
T
P
V
-----------
D
-------
G
-
L
-
E
GTVKEDH
I
-----
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
--
P
F
P
-
G
I
E
I
-
D
-----
E
E-----
K
I
-
V
-
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
Q
K
F
--
L
K
K
-
Q
GL
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
K
N
V
--
V
E
I
V
V
-
E
--
D
---
T
-
K
---
T
N
--
K
QE
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
G
-
P
-
M
-
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
--
G
--
H
V
--
N
Y
N
N
I
P
------
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
-
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
-
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
---
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
109
HHSearch
78.87
40%
-83
- C1 -
1LVL
2
DLDH1_PSEPU
A:
[2-457]
-----
Q
T
I
Q
T
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-------
Q
-------
A
-------
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
H
---
V
A
E
--
Q
F
H
Q
A
S
-
R
---
F
-
T
E
PS
P
L
-
G
I
S
V
-
A
-
S
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
-
V
A
A
L
L
K
K
-
H
G
-
V
K
V
V
H
G
W
A
K
V
L
D
G
---------
K
Q
V
E
V
------
D
-----------------------
G
-
Q
-------
R
-----
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
--
E
L
P
-
M
L
P
L
-
G
-----
G
------
P
V
-
I
-
S
S
T
E
A
L
A
P
K
-
A
-
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
-
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
T
Y
-
D
S
E
L
T
A
P
V
A
E
S
--
L
K
K
-
L
--
G
I
A
L
H
L
G
H
S
V
E
G
Y
E
N
G
C
------
L
L
A
-
N
--
D
---
G
K
G
---
G
Q
--
L
--
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
-
G
A
A
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
A
G
E
-
P
-
M
-
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
I
A
G
K
A
--
R
--
R
F
--
E
P
A
A
I
A
------
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
-
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
----
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
-
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
---
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
-
81
PsiBlast_CBE
78.73
37%
-78
- C1 -
1V59
4
DLDH_YEAST
A:
[6-477]
---------
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-------
R
G------
K
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
---
N
S
H
--
L
F
H
Q
M
H
T
E
---
A
-
Q
---
K
R
-
G
I
D
V
-
N
G
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
-
I
E
L
L
F
K
K
-
N
K
-
V
T
Y
Y
K
G
N
G
S
F
E
D
E
---------
T
K
I
R
V
------
T
P
V
-----------
D
-------
G
-
L
-
E
GTVK
E
D
H
I
-----
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
--
P
F
P
-
G
I
E
I
-
D
-----
E
E-----
K
I
-
V
-
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
Q
K
F
--
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
K
N
V
--
V
E
I
V
V
-
E
--
D
---
T
-
K
---
T
N
--
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
G
-
P
-
M
-
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
--
G
--
H
V
--
N
Y
N
N
I
P
------
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
-
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
-
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
---
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
43
PsiBlast_CBE
78.21
41%
-85
- C1 -
2EQ7
3
?
B:
[3-452]
----------
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-------
E
-------
K
A------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
---
T
T
E
--
R
I
Y
E
A
--
K
---
K
-
G
---
L
L
-
G
A
K
V
-
K
-
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
-
V
E
F
L
F
K
K
-
N
G
-
I
A
R
H
Q
G
T
A
R
F
L
S
E
---------
R
--
K
V
------
L
V
E
-----------
E
-------
T
-
G
-
E
-------
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
--
I
P
P
-
W
A
Q
V
-
D
Y----
E
------
R
V
-
V
-
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
-
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
E
R
V
--
F
K
K
-
Q
--
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
--
A
R
V
E
L
-
E
--
G
---
G
---------
E
--
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
-
M
-
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
--
G
--
H
V
--
D
Y
Q
A
I
P
------
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
-
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
-
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
---
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
---
11
PsiBlast_PDB
77.43
39%
-83
- C1 -
1LPF
2
DLDH_PSEFL
A:
[2-471]
-------
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-------
Y
-------
I
GKEGKVA
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
---
S
S
Y
--
K
Y
H
E
A
K
-
E
---
A
-
F
---
K
V
H
G
I
E
A
-
K
-
G
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
-
I
A
T
L
F
K
A
-
N
G
-
V
T
S
F
E
G
H
G
K
L
L
A
N
---------
K
Q
V
E
V
------
T
G
L
-----------
D
G------
K
-
T
-
Q
-------
V
-----
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
--
E
I
P
-
P
A
P
L
-
S
-----
D
------
D
I
-
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
-
D
E
Q
I
A
K
E
A
L
K
V
--
L
T
K
-
Q
--
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
--
V
T
V
T
F
T
D
--
A
---
N
-
G
---
E
Q
--
K
--
E
T
-
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
-
A
-
M
-
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
--
A
--
Q
M
--
N
Y
D
L
I
P
------
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
-
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
----
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
-
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
---
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
90
PsiBlast_CBE
77.33
36%
-88
- C1 -
3II4
3
DLDH_MYCTU
A:
[7-466]
----------
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-------
K
-------
Y
-------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
--
I
F
T
K
D
A
-
K
---
A
------
F
-
G
I
S
G
-
E
--
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
-
V
H
F
L
M
K
K
-
N
K
-
I
T
E
I
H
G
Y
G
T
F
A
D
A
---------
N
T
L
L
V
D-----
L
N
D
-----------
G
-------
G
-
T
-
E
-------
S
-----
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
--
L
V
P
-
G
T
S
L
-
S
-----
A
------
N
V
-
V
-
T
Y
E
E
Q
I
L
S
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
E
K
Q
--
F
K
K
-
L
--
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
G
S
Q
--
V
T
V
T
V
-
T
--
K
---
D
-
G
---
V
A
--
Q
--
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
-
L
-
Q
-
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
--
T
--
L
T
LG
D
H
R
M
L
P
------
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
-
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
---
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
F
82
PsiBlast_CBE
77.20
37%
-77
- C1 -
1JEH
2
DLDH_YEAST
B:
[6-477]
---------
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-------
R
G------
K
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
---
N
S
H
--
L
F
H
Q
M
H
T
E
---
A
-
Q
---
K
R
-
G
I
D
V
-
N
G
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
-
I
E
L
L
F
K
K
-
N
K
-
V
T
Y
Y
K
G
N
G
S
F
E
D
E
---------
T
K
I
R
V
------
T
P
V
-----------
D
-------
G
-
L
-
E
GTVKEDH
I
-----
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
--
P
F
P
-
G
I
E
I
-
D
-----
E
E-----
K
I
-
V
-
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
Q
K
F
--
L
K
K
-
Q
GL
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
K
N
V
--
V
E
I
V
V
-
E
--
D
---
T
-
K
---
T
N
--
K
QE
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
G
-
P
-
M
-
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
--
G
--
H
V
--
N
Y
N
N
I
P
------
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
-
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
-
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
---
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
119
HHSearch
76.68
37%
-83
- C1 -
2A8X
3
DLDH_MYCTU
A:
[2-463]
-------
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-------
K
-------
Y
-------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
---
N
A
E
--
L
V
H
I
F
T
K
D
---
A
-
K
---
A
F
-
G
I
S
G
---
E
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
-
V
H
F
L
M
K
K
-
N
K
-
I
T
E
I
H
G
Y
G
T
F
A
D
A
---------
N
T
L
L
V
------
D
L
N
-----------
D
-------
G
G
T
-
E
-------
S
-----
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
--
L
V
P
-
G
T
S
L
-
S
-----
A
------
N
V
-
V
-
T
Y
E
E
Q
I
L
S
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
-
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
E
K
Q
--
F
K
K
-
L
--
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
G
S
Q
--
V
T
V
T
V
-
T
--------
K
---
D
G
V
A
Q
--
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
-
L
-
Q
-
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
--
L
G
--
D
H
R
M
L
P
------
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
-
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
-
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
---
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
-
20
PsiBlast_PDB
76.55
37%
-77
- C1 -
1JEH
2
DLDH_YEAST
A:
[6-477]
---------
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-------
R
G------
K
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
---
N
S
H
--
L
F
H
Q
M
H
T
E
---
A
-
Q
---
K
R
-
G
I
D
V
-
N
G
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
-
I
E
L
L
F
K
K
-
N
K
-
V
T
Y
Y
K
G
N
G
S
F
E
D
E
---------
T
K
I
R
V
------
T
P
V
-----------
D
-------
G
-
L
-
E
GTVK
E
D
H
I
-----
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
--
P
F
P
-
G
I
E
I
-
D
-----
E
E-----
K
I
-
V
-
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
-
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
Q
K
F
--
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
K
N
V
--
V
E
I
V
V
-
E
--
D
---
T
-
K
---
T
N
--
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
G
-
P
-
M
-
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
--
G
--
H
V
--
N
Y
N
N
I
P
------
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
-
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
-
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
---
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
44
PsiBlast_CBE
76.11
39%
-80
- C1 -
1LPF
2
DLDH_PSEFL
B:
[2-471]
-------
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-------
Y
-------
I
GKEGKVA
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
---
S
S
Y
--
K
Y
H
E
A
K
-
E
---
A
-
F
---
K
V
H
G
I
E
A
-
K
-
G
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
-
I
A
T
L
F
K
A
-
N
G
-
V
T
S
F
E
G
H
G
K
L
L
A
N
---------
K
Q
V
E
V
------
T
G
L
-----------
D
G------
K
-
T
-
Q
-------
V
-----
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
--
E
I
P
-
P
A
P
L
-
S
-----
D
------
D
I
-
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
-
D
E
Q
I
A
K
E
A
L
K
V
--
L
T
K
-
Q
--
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
--
V
T
V
T
F
T
D
--
A
---
N
-
G
---
E
Q
--
K
--
E
T
-
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
-
A
-
M
-
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
--
A
--
Q
M
--
N
Y
D
L
I
P
------
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
-
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
----
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
-
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
---
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
8
PsiBlast_PDB
74.75
40%
-81
- C1 -
1LVL
2
DLDH1_PSEPU
A:
[18-458]
---------------------
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-------
Q
-------
A
-------
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
H
---
V
A
E
--
Q
F
H
Q
A
S
-
R
F
T
E
P
-
S
---
P
L
-
G
I
S
V
-
A
-
S
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
-
V
A
A
L
L
K
K
-
H
G
-
V
K
V
V
H
G
W
A
K
V
L
D
G
---------
K
Q
V
E
V
----------------------------
D
-
G
-
Q
-------
R
-----
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
--
E
L
P
-
M
L
P
L
-
G
-----
G
------
P
V
-
I
-
S
S
T
E
A
L
A
P
K
-
A
-
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
-
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
T
Y
-
D
S
E
L
T
A
P
V
A
E
S
--
L
K
K
-
L
--
G
I
A
L
---
H
L
G
H
S
V
E
G
Y
E
N
G
--
C
L
L
A
N
-
D
--
G
---
K
-
G
---
G
Q
--
L
--
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
G
A
A
-
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
A
G
E
-
P
-
M
-
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
I
A
G
K
A
--
R
--
R
F
--
E
P
A
A
I
A
------
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
-
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
----
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
-
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
---
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
I
84
PsiBlast_CBE
73.40
42%
-82
- C1 -
1BHY
1
?
A:
[19-472]
---------------------
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
Y------
K
-------
T
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
N
A
A
--
V
I
D
E
V
R
-
H
---
L
-
A
---
A
N
-
G
I
K
Y
-
P
-
E
P
E
L
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
G
-
L
A
G
M
A
K
S
-
R
K
-
V
D
V
I
Q
G
D
G
Q
F
L
D
P
---------
H
H
L
E
V
S
L
T
A
G
D
A
Y
E
-----------
Q
-------
A
-
A
-
P
-------
T
G
E
K
K
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
--
K
L
P
-
F
I
P
E
-
D
-----
P
------
R
I
-
I
-
D
S
S
G
A
L
A
L
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
-
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
G
A
-
D
R
D
L
V
K
V
W
Q
K
Q
N
E
Y
R
F
-
D
--
N
I
M
V
N
T
K
T
V
A
--
V
E
P
K
E
D
G
--
V
Y
V
T
F
-
E
G
-
A
---
N
-
A
---
P
K
--
E
--
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
G
Q
-
P
-
M
-
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
--
A
--
Y
F
--
D
A
R
V
I
P
------
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
-
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
----
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
-
N
G
G
D
M
I
G
E
V
Y
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
---
T
L
G
E
S
I
G
M
A
A
E
V
A
L
G
-----
83
PsiBlast_CBE
73.14
42%
-82
- C1 -
1OJT
1
?
A:
[19-472]
---------------------
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
Y------
K
-------
T
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
N
A
A
--
V
I
D
E
V
R
-
H
---
L
-
A
---
A
N
-
G
I
K
Y
-
P
-
E
P
E
L
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
G
-
L
A
G
M
A
K
S
-
R
K
-
V
D
V
I
Q
G
D
G
Q
F
L
D
P
---------
H
H
L
E
V
S
L
T
A
G
D
A
Y
E
-----------
Q
-------
A
-
A
-
P
-------
T
G
E
K
K
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
--
K
L
P
-
F
I
P
E
-
D
-----
P
------
R
I
-
I
-
D
S
S
G
A
L
A
L
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
-
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
G
A
-
D
R
D
L
V
K
V
W
Q
K
Q
N
E
Y
R
F
-
D
--
N
I
M
V
N
T
K
T
V
A
--
V
E
P
K
E
D
G
--
V
Y
V
T
F
-
E
G
-
A
---
N
-
A
---
P
K
--
E
--
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
G
Q
-
P
-
M
-
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
--
A
--
Y
F
--
D
A
R
V
I
P
------
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
-
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
----
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
-
N
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
---
T
L
G
E
S
I
G
M
A
A
E
V
A
L
G
-----
19
PsiBlast_PDB
72.76
40%
-76
- C1 -
2QAE
2
DLDH_TRYCR
A:
[17-468]
-----------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
-------
R
G------
A
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
A
T
H
--
L
Y
H
D
A
--
H
---
A
-
N
FA-
R
Y
-
G
L
M
G
G
E
-
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
-
V
E
Y
L
F
K
K
-
N
K
-
V
T
Y
Y
K
G
E
G
S
F
E
T
A
---------
H
S
I
R
V
------
N
G
L
-----------
D
-------
G
-
K
-
Q
E
------
M
-----
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
--
E
L
P
-
F
L
P
F
-
D
-----
E
------
K
V
V
L
-
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
A
L
V
G
A
--
L
-
A
-
K
--
N
E
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
G
--
D
S
V
S
L
-
E
--
V
E
GK-------
R
--
E
--
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
-
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
--
G
--
H
V
--
N
Y
G
V
I
P
------
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
-
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
-
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
---
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
F
79
PsiBlast_CBE
72.69
40%
-76
- C1 -
2QAE
2
DLDH_TRYCR
B:
[17-468]
-----------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
-------
R
G------
A
-------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
---
A
T
H
--
L
Y
H
D
A
--
H
---
A
-
N
FA-
R
Y
-
G
L
M
G
G
E
-
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
-
V
E
Y
L
F
K
K
-
N
K
-
V
T
Y
Y
K
G
E
G
S
F
E
T
A
---------
H
S
I
R
V
------
N
G
L
-----------
D
-------
G
-
K
-
Q
E------
M
-----
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
--
E
L
P
-
F
L
P
F
-
D
-----
E
------
K
V
V
L
-
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
-
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
A
L
V
G
A
--
L
-
A
-
K
--
N
E
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
G
--
D
S
V
S
L
-
E
--
V
EGK-------
R
--
E
--
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
-
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
--
G
--
H
V
--
N
Y
G
V
I
P
------
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
-
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
-
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
---
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
F
95
PsiBlast_CBE
68.21
32%
-81
- C1 -
4K8D
19
MERA_PSEAI
A:
[9-435]
-------------
V
I
G
S
G
G
A
A
M
A
A
A
L
K
A
V
E
Q
G
A
Q
V
T
L
I
E
R
-------
G
-------
T
-------
I
G
G
T
C
V
N
V
G
C
V
P
S
K
I
M
I
R
---
A
A
H
I
A
H
L
R
R
E
S
-
P
---
F
-
D
---
G
--
G
I
A
A
-
T
-
V
P
T
I
D
R
S
K
L
L
A
Q
Q
Q
A
R
V
D
E
L
R
H
A
K
Y
E
G
I
L
G
G
-
N
P
A
I
T
V
V
H
G
E
A
R
F
K
D
D
---------
Q
S
L
T
V
R-----
L
N
E
-----------
G
-------
G
-
E
-
R
-------
V
-----
V
M
F
D
R
C
L
V
A
T
G
A
S
P
A
V
P
P
I
P
-
G
L
K
E
-
S
-----
P
-------
Y
-
W
-
T
S
T
E
A
L
A
S
D
-
T
-
I
P
E
R
L
A
V
I
G
S
S
V
V
A
L
E
L
A
Q
A
F
A
R
-
L
G
S
K
V
T
V
L
A
R
N
-
T
L
F
F
R
E
-
D
P
A
I
G
E
A
V
T
A
A
--
F
R
A
-
E
--
G
I
E
V
L
E
H
T
Q
A
S
Q
V
A
H
M
-
D
G
--
E
F
V
L
T
-
T
--
T
---
H
-
G
---
E
-------
L
R
A
D
K
L
L
V
A
T
G
R
T
P
N
T
R
S
L
A
L
D
A
A
G
V
T
V
N
A
Q
G
A
I
V
I
D
Q
G
M
R
T
S
N
P
N
I
Y
A
A
G
D
C
T
D
Q
-
P
-
Q
-
F
V
Y
V
A
A
A
A
G
T
R
A
A
I
N
M
T
G
G
D
--
A
--
A
L
--
D
L
T
A
M
P
------
A
V
V
F
T
D
P
Q
V
A
T
V
G
Y
S
E
A
E
A
H
H
D
G
I
E
T
-
D
S
R
T
L
T
L
D
N
V
P
R
A
L
A
N
F
D
T
R
G
----
F
I
K
L
V
I
E
E
G
S
H
R
L
I
G
V
Q
A
V
A
P
-
E
A
G
E
L
I
Q
T
A
A
L
A
I
R
N
R
M
T
V
Q
E
L
A
------------------------------
93
PsiBlast_CBE
66.47
31%
-73
- C1 -
2R9Z
7
GASHR_MARGR
B:
[6-442]
----------
D
L
I
A
I
G
G
G
S
G
G
L
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
-------
K
-------
A
-------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
---
A
S
H
--
L
A
E
A
V
R
-
D
---
A
-
P
---
G
F
-
G
V
Q
A
-
S
-
G
-
T
L
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
-
W
D
G
Y
V
E
R
-
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
A
---------
H
T
I
E
V
----------------------------
E
-
G
-
Q
-------
R
-----
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
V
P
R
L
P
-
G
A
E
L
-
G
---------------
I
-
T
S
D
G
F
F
A
L
Q
-
Q
-
Q
P
K
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
-
F
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
-
D
P
L
L
S
A
T
L
A
E
N
--
M
H
A
-
Q
--
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
D
A
Q
G
----
T
T
L
-
V
--
A
---
Q
-
D
---
G
T
--
R
--
L
E
G
F
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
I
T
G
R
-
D
-
Q
-
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
F
D
G
Q
--
S
--
E
R
K
L
D
Y
D
N
I
P
------
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
D
V
L
T
V
Y
E
T
S
F
T
P
M
R
Y
A
L
N
E
H
G
P
K
T
----
A
M
K
L
V
C
A
G
P
E
Q
R
V
V
G
V
H
V
I
G
D
-
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
----------------
94
PsiBlast_CBE
65.44
31%
-74
- C1 -
2R9Z
7
GASHR_MARGR
A:
[6-442]
----------
D
L
I
A
I
G
G
G
S
G
G
L
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
-------
K
-------
A
-------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
---
A
S
H
--
L
A
E
A
V
R
-
D
---
A
-
P
---
G
F
-
G
V
Q
A
-
S
----
L
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
-
W
D
G
Y
V
E
R
-
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
A
---------
H
T
I
E
V
----------------------------
E
-
G
-
Q
-------
R
-----
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
V
P
R
L
P
-
G
A
E
L
-
G
---------------
I
-
T
S
D
G
F
F
A
L
Q
-
Q
-
Q
P
K
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
-
F
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
-
D
P
L
L
S
A
T
L
A
E
N
--
M
H
A
-
Q
--
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
D
A
Q
G
----
T
T
L
-
V
--
A
---
Q
-
D
---
G
T
--
R
--
L
E
G
F
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
I
T
G
R
-
D
-
Q
-
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
F
D
G
Q
--
S
--
E
R
KL
D
Y
D
N
I
P
------
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
D
V
L
T
V
Y
E
T
S
F
T
P
M
R
Y
A
L
N
E
H
G
P
K
T
----
A
M
K
L
V
C
A
G
P
E
Q
R
V
V
G
V
H
V
I
G
D
-
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
----------------
129
HHSearch
65.00
30%
-72
- C1 -
2R9Z
8
GASHR_MARGR
A:
[2-454]
------
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
A
V
A
E
K
A
A
A
F
G
K
R
V
A
L
I
E
S
-------
K
-------
A
-------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
---
A
S
H
--
L
A
E
A
V
R
-
D
---
A
-
P
---
G
F
-
G
V
Q
A
-
S
----
L
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
-
W
D
G
Y
V
E
R
-
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
A
---------
H
T
I
E
V
------
E
-----------------------
G
-
Q
-------
R
-----
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
--
V
P
R
-
L
P
G
A
-
E
------------
L
G
-
I
-
T
S
D
G
F
F
A
L
Q
-
Q
-
Q
P
K
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
S
-
F
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
-
D
P
L
L
S
A
T
L
A
E
N
--
M
H
A
-
Q
--
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
D
A
Q
G
--
T
T
L
V
A
----------
Q
---
D
G
--
T
R
-
L
E
G
F
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
I
T
G
R
-
D
-
Q
-
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
F
D
G
Q
--
S
ER
K
L
--
D
Y
D
N
I
P
------
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
D
V
L
T
V
Y
E
T
S
F
T
P
M
R
Y
A
L
N
E
H
G
P
K
T
----
A
M
K
L
V
C
A
G
P
E
Q
R
V
V
G
V
H
V
I
G
D
-
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
K
E
P
V
R
R
P
----