@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1072: (2016-03-21 )
MNRIKKVLVANRGEIAIRVMRACTELKIKTVAIYSQEDTGSFHRYKSDEAYLVGAGKKPIDAYLDIENIIEIAKESGADAIHPGYGFLSENIEFARRCEQEGIIFVGPKSKHLDMFGDKIKAKEQALLADIPVIPGSNGPVAGIKEVEEFGEKNGYPLMIKASLGGGGRGMRVVESKEHVKESFERASSEAKAAFGNDEVYVEKCVMNPKHIEVQILGDTHGNIVHLFERDCSIQRRHQKVVEVAPCNAITSELRNRICDAAVKLMKNVDYINAGTVEFLVEGDDFYFIEVNPRVQVEHTITEMITGIDIVQSQLFIADGYALHDQLVAIPKQEDIHIHGSAIQSRITTEDPLNNFMPDTGRVDTYRSTGGFGVRLDAGNGFQGTVVTPFYDSLLVKLCTWGMTFEQATRKMRRNLIEFRIRGVKTNIPFLLNVVRHPDFASGNYNTSFIDTTPELFKFPHIRDRGTKTLRYIGNVTVNGFPGIKHRDKPVYAEPRLPKIPYGSQISPGTKQILDAKGPEGVVDWVKKQEEVLLTDTTLRDAHQSLLATRVRSKDIFQVADAMAHLLPNMFSFEMWGGATFDVAYRFLNEDPWVRLETLRKQIPNVMFQMLLRGANAVGYKNYPDNVIREFVKQSAQSGVDVFRVFDSLNWIKGMEVSIDAVREAGKVVEAAICYTGDIDDDTRTKYTIDYYKDMAKELVAQGTHILGIKDMAGLLKPQAAYRLIGELKDTVDVPIHLHTHDTSGNGIYTYAAAVSAGVDIVDVASSAMSGATSQPSMTGLYYGLVNGNRQTNLDAQNSQIINHYWEDVRHYYKDFDNALNSPQTEVYIHEMPGGQYTNLQQQAIAVGLGDRWDEVKEMYTVVNQMFGDIVKVTPSSKVVGDLALFMVQNELSEEDVYEKGDTIDFPDSVIEFFMGEIGQPYGGFPEKLQKLVLKGRTPLTDRPGALMEPVNFVDVKAELKEKMGYEPTEKDVISYILYPKVFLDYQDMINKYGDVTVLDTPTFYKGMRLGETIEVELEKGKILLIKLNSIGEPIADGTRVIYFELNGQPREINIQDMNVQSTVIARRKIDTTNPEHVGATMTGSVIQVVVKKGDSVKKGDPLLITEAMKMETTIQAPFDGEVSSIYVSDGDTIESGDLLIEVNRI
Atome Classification :
(63 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.-......140.-.....-.150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280-..--.-.--....290.......300.......310.......320.......330....--....340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.-....--..510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680..-..-...690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
R
I
K
K
V
L
VANR
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
SQEDTGSFHRYKSDE
A
Y
L
VGAGKK
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
ESGADAIHPG
Y
G
F
L
S
EN
I
E
F
A
R
R
CEQE
G
I
I
F
VGPKS
K
H
L
D
MFG
D
K
I
K
A
K
E
Q
A
L
LADIPV-IPGSNGPVA
G
-
I
K
E
V
E
-
E
F
G
EKNG
Y
P
L
M
I
K
A
SLGGGGR
G
M
R
V
V
E
S
K
E
H
V
K
E
S
F
E
R
ASSEAKAAFGND
E
V
Y
V
E
K
CVMNP
K
H
I
E
V
Q
I
L
GDTHG
N
I
V
H
L
FERDC
S
I
Q
R
R
H
Q
K
V
VEVAP
C
N
A
I
T
S
E
L
R
N
R
I
C
D
A
A
V
K
L
M
KNVDYINAG
T
V
E
F
L
V
--EG--D-
D
--
F
Y
F
I
EVNP
R
V
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
L
F
IADG
Y
A
L
H
D
Q
L
VAIP-KQE
D
--
I
H
I
H
G
S
A
I
Q
SRITTED
P
L
N
NFMPDTGRV
D
T
Y
RSTGG
F
G
V
R
LDAGNGFQ
G
T
V
V
T
P
F
Y
D
S
L
L
V
K
LCTWGM
T
F
E
Q
A
T
R
K
M
R
R
N
L
I
E
F
R
IRGVKTN
I
P
F
L
L
N
V
VRHPDFASGNYNTSFIDT
T
P
E
L
FKFPHIRDRG
T
K
T
L
R
Y
I
G
N
V
T
VNGFPGIKHRDKPVYAEPRLPKIPYG-SQIS--PG
T
K
Q
I
LDAKGP
E
G
V
V
D
W
V
K
KQE
E
V
L
LTD
T
T
L
R
D
A
H
Q
S
L
L
A
T
R
VRS
K
D
I
F
Q
V
A
D
A
M
A
H
L
L
P
N
M
F
S
F
E
MWGG
A
T
F
D
V
A
Y
R
F
LNEDPW
V
R
L
E
T
L
R
K
Q
I
P
N
V
M
F
Q
M
L
L
RGANAVGYKNY
P
D
N
V
I
R
E
F
V
K
Q
S
A
QSG
V
D
V
F
R
V
F
D
SLNWIKGME
V
S
I
D
A
V
R
EA
G
K
V
V
E
A
A
I
C
Y
TGDIDDDTR-
T
K
-
Y
T
I
D
Y
Y
K
D
M
A
K
E
L
V
AQG
T
H
I
L
G
I
K
D
M
A
G
LL
K
P
Q
A
A
Y
R
L
I
G
E
LKDTV
D
V
P
I
H
L
H
THDTSGN
G
I
Y
T
Y
A
A
A
VSAGV
D
I
V
D
V
A
S
S
AMSGATSQPS
M
T
G
L
Y
Y
G
LVNGNRQTNLDAQ
N
S
Q
I
I
N
H
Y
W
E
D
V
R
H
Y
Y
K
D
F
D
N
ALNSPQ
T
E
V
Y
I
H
EMPGGQYT
N
L
Q
Q
Q
A
I
AVGLG
D
R
W
D
E
V
K
E
M
Y
T
V
V
N
Q
M
F
G
D
I
V
KVTPSS
K
V
V
G
D
L
A
L
F
M
V
QNELSE
E
D
V
YEKGDTIDF
P
D
S
V
I
E
F
F
M
G
EIGQPYGG
F
P
E
K
L
Q
K
L
V
LKGRTPLTDRPGALMEPVN
F
V
D
V
K
A
E
L
K
E
KMGYEP
T
E
K
D
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
D
M
I
N
KYG
D
V
T
V
LDT
P
T
F
YKGMRLG
E
T
I
E
V
E
LEKG
K
I
L
L
I
K
LNSIGEPIADG
T
R
V
I
Y
F
E
LNGQP
R
E
I
N
I
Q
DMNV
Q
S
T
V
I
A
RRKIDTTNPEHVGATM
T
G
S
V
I
Q
V
V
V
KKGDSVKKGD
P
L
L
I
T
EAM
K
M
E
T
T
IQAPFDGE
V
S
S
I
Y
VSDGDTIESG
D
L
L
I
E
VNRI
23
PsiBlast_CBE
85.57
99%
-94
- C2 -
4QSH
4
?
B:
[3-1147]
M
N
R
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
A
G
K
K
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
-
I
P
----------------------------------------------------------------------
K
C
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
L
F
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
V
A
P
C
N
A
I
T
S
E
L
R
N
R
I
C
D
A
A
V
K
L
M
K
N
V
D
Y
I
N
A
G
T
V
E
F
L
V
--
E
G
--
D
-
D
--
F
Y
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
L
F
I
A
D
G
Y
A
L
H
D
Q
L
V
A
I
P
-
K
Q
E
D
--
I
H
I
H
G
S
A
I
Q
S
R
I
T
T
E
D
P
L
N
N
F
M
P
D
T
G
R
V
D
T
Y
R
S
T
G
G
F
G
V
R
L
D
A
G
N
G
F
Q
G
T
V
V
T
P
F
Y
D
S
L
L
V
K
L
C
T
W
G
M
T
F
E
Q
A
T
R
K
M
R
R
N
L
I
E
F
R
I
R
G
V
K
T
N
I
P
F
L
L
N
V
V
R
H
P
D
F
A
S
G
N
Y
N
T
S
F
I
D
T
T
P
E
L
F
K
F
P
H
I
R
D
R
G
T
K
T
L
R
Y
I
G
N
V
T
V
N
G
F
P
G
I
K
H
R
D
K
P
V
Y
A
E
P
R
L
P
K
I
P
Y
G
-
S
Q
I
S
--
P
G
T
K
Q
I
L
D
A
K
G
P
E
G
V
V
D
W
V
K
K
Q
E
E
V
L
L
T
D
T
T
L
R
D
A
H
Q
S
L
L
A
T
R
V
R
S
K
D
I
F
Q
I
A
D
A
M
A
H
L
L
P
N
M
F
S
F
E
M
W
G
G
A
T
F
D
V
A
Y
R
F
L
N
E
D
P
W
V
R
L
E
T
L
R
K
Q
I
P
N
V
M
F
Q
M
L
L
R
G
A
N
A
V
G
Y
K
N
Y
P
D
N
V
I
R
E
F
V
K
Q
S
A
Q
S
G
V
D
V
F
R
V
F
D
S
L
N
W
I
K
G
M
E
V
S
I
D
A
V
R
E
A
G
K
I
V
E
A
A
I
C
Y
T
G
D
I
D
D
D
T
R
-
T
K
-
Y
T
I
D
Y
Y
K
D
M
A
K
E
L
V
A
Q
G
T
H
I
L
G
I
K
D
M
A
G
L
L
K
P
Q
A
A
Y
R
L
I
G
E
L
K
D
T
V
D
V
P
I
H
L
H
T
H
D
T
S
G
N
G
I
Y
T
Y
A
A
A
V
S
A
G
V
D
I
V
D
V
A
S
S
A
M
S
G
A
T
S
Q
P
S
M
T
G
L
Y
Y
G
L
V
N
G
N
R
Q
T
N
L
D
A
Q
N
S
Q
I
I
N
H
Y
W
E
D
V
R
H
Y
Y
K
D
F
D
N
A
L
N
S
P
Q
T
E
V
Y
I
H
E
M
P
G
G
Q
Y
T
N
L
Q
Q
Q
A
I
A
V
G
L
G
D
R
W
D
E
V
K
E
M
Y
T
V
V
N
Q
M
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
L
A
L
F
M
V
Q
N
E
L
S
E
E
D
V
Y
E
K
G
D
T
I
D
F
P
D
S
V
I
E
F
F
M
G
E
I
G
Q
P
Y
G
G
F
P
E
K
L
Q
K
L
V
L
K
G
R
T
P
L
T
D
R
P
G
A
L
M
E
P
V
N
F
V
E
V
K
A
E
L
K
E
K
M
G
Y
E
P
T
E
K
D
V
I
S
Y
I
L
Y
P
K
V
F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
Q
----
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
S
V
I
Q
V
V
V
K
K
G
D
S
V
K
K
G
D
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
E
V
S
S
I
Y
V
S
D
G
D
T
I
E
S
G
D
L
L
I
E
V
N
R
-
22
PsiBlast_CBE
85.49
99%
-93
- C2 -
4QSH
4
?
C:
[3-1147]
M
N
R
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
A
G
K
K
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
-
I
P
G
S
----------------------------------------------------------------
V
Y
V
E
K
C
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
L
F
E
R
D
C
S
I
Q
R
R
H
Q
K
V
V
E
V
A
P
C
N
A
I
T
S
E
L
R
N
R
I
C
D
A
A
V
K
L
M
K
N
V
D
Y
I
N
A
G
T
V
E
F
L
V
--
E
G
--
D
-
D
--
F
Y
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
I
T
G
I
D
I
V
Q
S
Q
L
F
I
A
D
G
Y
A
L
H
D
Q
L
V
A
I
P
-
K
Q
E
D
--
I
H
I
H
G
S
A
I
Q
S
R
I
T
T
E
D
P
L
N
N
F
M
P
D
T
G
R
V
D
T
Y
R
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S
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P
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Y
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L
Q
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L
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W
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----
A
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L
L
I
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V
N
R
-
1
PsiBlast_PDB
85.37
99%
-94
- C2 -
4QSK
3
?
A:
[2-1146]
M
N
R
I
K
K
V
L
V
A
N
R
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E
I
A
I
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V
M
R
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I
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I
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A
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I
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F
G
D
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A
K
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A
L
L
A
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I
P
V
-
I
P
-----------------------------------------------------------------------
C
V
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V
Q
----
A
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D
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D
T
I
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G
D
L
L
I
E
V
N
R
-
21
PsiBlast_CBE
85.11
99%
-94
- C2 -
4QSK
3
?
B:
[2-1146]
M
N
R
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
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A
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L
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G
A
G
K
K
P
I
D
A
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L
D
I
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N
I
I
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I
A
K
E
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G
A
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A
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P
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Y
G
F
L
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I
E
F
A
R
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C
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Q
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G
I
I
F
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G
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L
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F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
-
I
P
-----------------------------------------------------------------------
C
V
M
N
P
K
H
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L
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D
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G
N
I
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A
L
F
M
V
Q
N
E
L
S
E
E
D
V
Y
E
K
G
D
T
I
D
F
P
D
S
V
I
E
F
F
M
G
E
I
G
Q
P
Y
G
G
F
P
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K
L
Q
K
L
V
L
K
G
R
T
P
L
T
D
R
P
G
A
L
M
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P
V
N
F
V
E
V
K
A
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L
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E
K
M
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Y
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P
T
E
K
D
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I
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Y
I
L
Y
P
K
V
F
L
D
Y
Q
E
M
I
N
K
Y
G
D
V
T
V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
E
V
E
L
E
K
G
K
I
L
L
I
K
L
N
S
I
G
E
P
I
A
D
G
T
R
V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
Q
----
A
R
R
K
I
D
T
T
N
P
E
H
V
G
A
T
M
T
G
S
V
I
Q
V
V
V
K
K
G
D
S
V
K
K
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D
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L
L
I
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E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
E
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S
S
I
Y
V
S
D
G
D
T
I
E
S
G
D
L
L
I
E
V
N
R
-
2
PsiBlast_PDB
85.09
99%
-93
- C2 -
4QSH
4
?
A:
[3-1147]
M
N
R
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
C
T
E
L
K
I
K
T
V
A
I
Y
S
Q
E
D
T
G
S
F
H
R
Y
K
S
D
E
A
Y
L
V
G
A
G
K
K
P
I
D
A
Y
L
D
I
E
N
I
I
E
I
A
K
E
S
G
A
D
A
I
H
P
G
Y
G
F
L
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E
N
I
E
F
A
R
R
C
E
Q
E
G
I
I
F
V
G
P
K
S
K
H
L
D
M
F
G
D
K
I
K
A
K
E
Q
A
L
L
A
D
I
P
V
-
I
-------------------------------------------------------------------------
V
M
N
P
K
H
I
E
V
Q
I
L
G
D
T
H
G
N
I
V
H
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L
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N
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D
Y
I
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L
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--
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--
D
-
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--
F
Y
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-
S
Q
I
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--
P
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V
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K
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E
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A
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L
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A
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L
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M
I
N
K
Y
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D
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V
L
D
T
P
T
F
Y
K
G
M
R
L
G
E
T
I
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V
E
L
E
K
G
K
I
L
L
I
K
L
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I
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I
A
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V
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Y
F
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N
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Q
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I
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M
N
V
Q
----
A
R
R
K
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T
N
P
E
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V
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A
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M
T
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V
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D
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D
T
I
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S
G
D
L
L
I
E
V
N
R
-
3
PsiBlast_PDB
82.85
99%
-93
- C2 -
4QSL
-
?
H:
[1-1060]
M
N
R
I
K
K
V
L
V
A
N
R
G
E
I
A
I
R
V
M
R
A
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I
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A
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I
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P
V
-
I
P
G
S
N
G
P
---------------------------------
R
V
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--
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--
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-
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L
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V
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T
T
P
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L
F
K
F
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T
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N
G
F
P
G
I
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D
K
P
V
Y
A
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R
L
P
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Y
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-
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Q
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--
P
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L
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L
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D
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L
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N
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T
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M
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A
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K
L
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L
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A
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F
V
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A
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K
M
G
Y
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D
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Y
I
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P
K
V
F
L
D
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M
I
N
K
Y
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D
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T
V
L
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T
P
T
F
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M
R
L
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L
E
K
G
K
I
L
L
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L
N
S
I
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A
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V
I
Y
F
E
L
N
G
Q
P
R
E
I
N
I
Q
D
M
N
V
--------------------------------------------------------------------------------------
25
PsiBlast_CBE
82.70
61%
-88
- C2 -
3HO8
4
?
C:
[3-1061]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
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T
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A
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N
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Y
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N
I
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R
I
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D
V
A
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Q
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D
A
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F
L
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Q
F
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R
C
A
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E
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I
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F
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P
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D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
G
T
D
------------------------------------------------------------------
E
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
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R
H
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K
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V
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V
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S
V
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L
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P
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R
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C
D
A
A
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Q
L
M
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N
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K
Y
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N
A
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T
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E
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L
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--
S
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--
D
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A
A
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--
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Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
-
S
K
I
A
S
F
S
G
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Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
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R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
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L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
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N
Y
P
D
N
V
I
H
K
F
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A
K
A
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F
R
I
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L
N
W
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M
K
V
A
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A
V
Q
E
A
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K
I
S
E
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T
I
C
Y
T
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D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
27
PsiBlast_CBE
82.21
61%
-89
- C2 -
3HB9
3
?
D:
[3-1113]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
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N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
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H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
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C
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V
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A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
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F
L
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--
S
G
--
D
-
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--
F
F
F
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P
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T
G
I
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A
A
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A
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F
G
E
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N
M
P
-
Q
Q
K
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--
I
T
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G
F
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L
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N
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Y
E
L
A
S
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V
S
-
S
-
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K
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A
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S
G
T
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P
K
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K
Q
D
D
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L
L
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L
L
A
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I
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A
D
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D
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E
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W
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L
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A
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S
N
I
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F
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M
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A
Y
E
L
I
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K
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A
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D
L
P
I
H
L
H
T
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D
T
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N
G
L
L
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Y
K
Q
A
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A
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D
I
I
D
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A
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M
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A
N
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L
Y
Y
A
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F
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W
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D
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D
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I
Y
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P
G
G
Q
Y
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L
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Q
Q
A
K
S
L
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L
G
E
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F
D
E
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K
D
M
Y
R
R
V
N
F
L
F
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D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
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Q
N
D
L
D
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I
T
D
G
Y
K
L
D
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P
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V
V
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F
F
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G
E
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Q
P
V
N
G
F
N
K
D
L
Q
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V
I
L
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G
Q
E
A
L
T
A
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P
G
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L
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L
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Q
G
P
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D
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I
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Y
V
L
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P
K
V
Y
E
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Y
I
Q
T
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N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
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M
R
N
G
E
T
V
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I
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D
K
G
K
R
L
I
I
K
L
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I
S
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D
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N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
------------------------------------------------
A
M
K
M
-----------------------------------
26
PsiBlast_CBE
81.96
61%
-88
- C2 -
3HO8
4
?
B:
[3-1061]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
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A
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N
E
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A
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Y
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N
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V
A
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A
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Q
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A
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C
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F
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K
V
K
A
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A
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K
A
D
L
P
V
-
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
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V
Q
V
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D
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G
N
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V
H
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I
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D
A
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Y
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L
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--
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--
F
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P
-
Q
Q
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--
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R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
36
PsiBlast_CBE
81.82
61%
-88
- C2 -
4HNU
2
?
D:
[26-1084]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
--
D
-
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
I
N
M
P
-
Q
Q
K
D
--
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
E
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
-
S
K
I
A
SF
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
39
PsiBlast_CBE
81.58
61%
-89
- C2 -
4HNT
2
?
D:
[26-1084]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
--
D
-
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
I
N
M
P
-
Q
Q
K
D
--
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
A
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
-
S
K
I
A
SF
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
E
S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.47
61%
-86
- C2 -
3HO8
3
?
A:
[3-1061]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
G
T
D
-------------------------------------------------------------------
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
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D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
--
D
-
E
--
F
F
F
I
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P
R
V
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V
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I
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A
A
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A
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L
F
G
E
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I
N
M
P
-
Q
Q
K
D
--
I
T
T
L
G
Y
A
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Q
C
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I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
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R
L
D
A
G
D
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Q
G
A
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Y
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L
L
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L
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A
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I
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I
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F
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F
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E
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I
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P
S
L
D
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G
T
K
T
L
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Y
I
G
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V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
-
S
K
I
A
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F
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G
T
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Q
L
L
D
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P
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G
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A
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K
Q
D
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L
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A
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L
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L
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A
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N
A
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Y
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N
Y
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D
N
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A
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A
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W
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A
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A
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T
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C
Y
T
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D
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N
P
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-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
38
PsiBlast_CBE
81.07
61%
-87
- C2 -
4HNU
1
?
B:
[26-1084]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
--
D
-
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
I
N
M
P
-
Q
Q
K
D
--
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
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T
H
A
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F
K
Q
A
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E
E
M
V
R
S
L
R
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M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
-
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
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G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
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N
Y
P
D
N
V
I
H
K
F
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A
K
A
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I
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V
F
R
I
F
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L
N
W
V
D
Q
M
K
V
A
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A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
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D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
41
PsiBlast_CBE
80.45
61%
-88
- C2 -
4HNT
2
?
B:
[26-1084]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
--
D
-
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
I
N
M
P
-
Q
Q
K
D
--
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
A
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
-
S
K
I
A
S
F
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
F
D
V
A
Y
N
F
L
K
E
N
P
W
E
R
L
E
R
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
R
A
S
N
A
V
G
Y
K
N
Y
P
D
N
V
I
H
K
F
V
Q
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S
A
K
A
G
I
D
V
F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
S
G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
S
Q
P
S
A
N
S
L
Y
Y
A
L
N
G
F
P
R
H
L
R
T
D
I
E
G
M
E
S
L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
T
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
24
PsiBlast_CBE
77.20
61%
-83
- C2 -
3HO8
3
?
D:
[3-1061]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
E
R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
------------------------------------------------------------------------
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
--
D
-
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
I
N
M
P
-
Q
Q
K
D
--
I
T
T
L
G
Y
A
I
Q
C
R
I
T
T
E
D
P
L
N
D
F
M
P
D
T
G
T
I
I
A
Y
R
S
S
G
G
F
G
V
R
L
D
A
G
D
G
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
F
K
Q
A
E
E
K
M
V
R
S
L
R
E
M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
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I
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P
S
L
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T
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T
L
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Y
I
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N
V
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F
P
N
V
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K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
-
S
-
S
K
I
A
SF
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
R
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A
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Q
S
L
L
A
T
R
V
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
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A
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N
F
L
K
E
N
P
W
E
R
L
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L
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K
A
I
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L
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M
L
L
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A
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N
A
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Y
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N
Y
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L
N
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A
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A
G
K
I
S
E
G
T
I
C
Y
T
G
D
I
L
N
P
E
R
-
S
N
I
Y
T
L
E
Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
I
K
D
M
A
G
L
L
K
P
K
A
A
Y
E
L
I
G
E
L
K
S
A
V
D
L
P
I
H
L
H
T
H
D
T
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G
N
G
L
L
T
Y
K
Q
A
I
D
A
G
V
D
I
I
D
T
A
V
A
S
M
S
G
L
T
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Q
P
S
A
N
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L
Y
Y
A
L
N
G
F
P
R
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L
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T
D
I
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G
M
E
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L
S
H
Y
W
S
T
V
R
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Y
Y
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D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
-----------
L
G
L
G
E
R
F
D
E
V
K
D
M
------------
K
V
T
P
S
S
K
V
V
--------------------------------
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
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P
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Y
V
L
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Y
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N
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L
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L
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M
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N
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L
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N
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Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
---------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.84
61%
-86
- C2 -
3BG5
5
?
A:
[26-1169]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
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F
R
A
A
A
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L
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F
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V
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A
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T
A
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-
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-
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-
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A
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-------
R
I
V
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E
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L
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A
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A
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A
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Y
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Y
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A
A
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Y
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N
A
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T
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L
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--
S
G
--
D
-
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--
F
F
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F
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E
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D
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L
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Y
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N
Q
Y
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N
L
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L
L
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A
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N
N
G
D
T
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A
T
G
D
L
L
I
E
I
E
--
6
PsiBlast_PDB
76.27
61%
-87
- C2 -
3HBL
3
?
A:
[3-1146]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
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A
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I
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A
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E
V
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Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
V
H
T
N
A
N
V
K
P
K
A
D
K
S
N
P
S
H
I
G
A
Q
M
P
G
S
V
T
E
V
K
V
S
V
G
E
T
V
K
A
N
Q
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
V
I
K
Q
V
T
V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
E
--
109
HHSearch
76.18
61%
-87
- C2 -
3HBL
3
?
A:
[3-1146]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
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L
D
I
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A
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E
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Y
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A
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L
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L
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A
K
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A
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A
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P
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Y
G
F
L
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N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
G
T
D
G
P
I
K
S
-
Y
E
L
A
K
-
E
F
A
E
E
A
G
F
P
L
M
I
K
A
T
S
-------
R
I
V
R
E
E
S
E
L
E
D
A
F
H
R
A
K
S
E
A
E
------
E
V
Y
I
E
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
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H
G
N
I
V
H
L
F
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D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
--
D
-
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
I
N
M
P
-
Q
Q
K
D
--
I
T
T
L
G
Y
A
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C
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T
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D
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L
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D
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Y
Y
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L
L
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L
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A
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A
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M
V
R
S
L
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R
I
R
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K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
V
S
S
S
K
I
A
S
F
--
S
G
T
K
Q
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
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T
T
F
R
D
A
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Q
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L
L
A
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V
R
T
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D
M
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N
I
A
S
K
T
A
D
V
F
K
D
G
F
S
L
E
M
W
G
G
A
T
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A
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N
F
L
K
E
N
P
W
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L
E
R
L
R
K
A
I
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N
V
L
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Q
M
L
L
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A
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N
A
V
G
Y
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Y
P
D
N
V
I
H
K
F
V
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A
K
A
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F
R
I
F
D
S
L
N
W
V
D
Q
M
K
V
A
N
E
A
V
Q
E
A
G
K
I
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E
G
T
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C
Y
T
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D
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L
N
P
E
R
S
N
I
-
Y
T
L
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Y
Y
V
K
L
A
K
E
L
E
R
E
G
F
H
I
L
A
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D
M
A
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L
L
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P
K
A
A
Y
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L
I
G
E
L
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A
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D
L
P
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L
H
T
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G
N
G
L
L
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A
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A
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A
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Y
Y
A
L
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L
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I
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L
S
H
Y
W
S
T
V
R
T
Y
Y
S
D
F
E
S
D
I
K
S
P
N
T
E
I
Y
Q
H
E
M
P
G
G
Q
Y
S
N
L
S
Q
Q
A
K
S
L
G
L
G
E
R
F
D
E
V
K
D
M
Y
R
R
V
N
F
L
F
G
D
I
V
K
V
A
P
S
S
K
V
V
G
D
M
A
L
Y
M
V
Q
N
D
L
D
E
Q
S
V
I
T
D
G
Y
K
L
D
F
P
E
S
V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
K
D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
V
H
T
N
A
N
V
K
P
K
A
D
K
S
N
P
S
H
I
G
A
Q
M
P
G
S
V
T
E
V
K
V
S
V
G
E
T
V
K
A
N
Q
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
V
I
K
Q
V
T
V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
E
--
5
PsiBlast_PDB
75.72
61%
-86
- C2 -
3HB9
4
?
A:
[3-1146]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
R
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
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R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
I
K
A
D
L
P
V
-
I
P
G
T
D
G
P
I
K
S
-
Y
E
L
A
K
-
E
F
A
E
E
A
G
F
P
L
M
I
K
A
T
S
-------
R
I
V
R
E
E
S
E
L
E
D
A
F
H
R
A
K
S
E
A
E
K
----
S
E
V
Y
I
E
R
Y
I
D
N
P
K
H
I
E
V
Q
V
I
G
D
E
H
G
N
I
V
H
L
F
E
R
D
C
S
V
Q
R
R
H
Q
K
V
V
E
V
A
P
S
V
G
L
S
P
T
L
R
Q
R
I
C
D
A
A
I
Q
L
M
E
N
I
K
Y
V
N
A
G
T
V
E
F
L
V
--
S
G
--
D
-
E
--
F
F
F
I
E
V
N
P
R
V
Q
V
E
H
T
I
T
E
M
V
T
G
I
D
I
V
K
T
Q
I
L
V
A
A
G
A
D
L
F
G
E
E
I
N
M
P
-
Q
Q
K
D
--
I
T
T
L
G
Y
A
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Q
C
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I
T
T
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D
P
L
N
D
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M
P
D
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T
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I
A
Y
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S
G
G
F
G
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R
L
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A
G
D
G
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G
A
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Y
Y
D
S
L
L
V
K
L
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A
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F
K
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A
E
E
K
M
V
R
S
L
R
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M
R
I
R
G
V
K
T
N
I
P
F
L
I
N
V
M
K
N
K
K
F
T
S
G
D
Y
T
T
K
F
I
E
E
T
P
E
L
F
D
I
Q
P
S
L
D
R
G
T
K
T
L
E
Y
I
G
N
V
T
I
N
G
F
P
N
V
E
K
R
P
K
P
D
Y
E
L
A
S
I
P
T
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S
-
S
-
S
K
I
A
S
F
S
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T
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Q
L
L
D
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V
G
P
K
G
V
A
E
W
V
K
K
Q
D
D
V
L
L
T
D
T
T
F
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A
H
Q
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L
L
A
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R
V
R
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D
M
I
N
I
A
S
K
T
A
D
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F
K
D
G
F
S
L
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M
W
G
G
T
T
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D
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A
Y
N
F
L
K
E
N
P
W
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L
E
R
L
R
K
A
I
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N
V
L
F
Q
M
L
L
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A
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N
A
V
G
Y
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N
Y
P
D
N
V
I
H
K
F
V
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A
K
A
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I
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F
R
I
F
D
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L
N
W
V
D
Q
M
K
V
A
N
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A
V
Q
E
A
G
K
I
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E
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T
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C
Y
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N
P
E
R
-
S
N
I
Y
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L
E
Y
Y
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K
L
A
K
E
L
E
R
E
G
F
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I
L
A
I
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D
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A
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L
L
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A
A
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L
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Y
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L
S
H
Y
W
S
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R
T
Y
Y
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D
F
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D
I
K
S
P
N
T
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I
Y
Q
H
E
M
P
G
G
Q
Y
S
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L
S
Q
Q
A
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L
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L
G
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D
M
Y
R
R
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F
L
F
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D
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K
V
V
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D
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A
L
Y
M
V
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L
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Q
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I
T
D
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Y
K
L
D
F
P
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V
V
S
F
F
K
G
E
I
G
Q
P
V
N
G
F
N
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D
L
Q
A
V
I
L
K
G
Q
E
A
L
T
A
R
P
G
E
Y
L
E
P
V
D
F
E
K
V
R
E
L
L
E
E
E
Q
Q
G
P
V
T
E
Q
D
I
I
S
Y
V
L
Y
P
K
V
Y
E
Q
Y
I
Q
T
R
N
Q
Y
G
N
L
S
L
L
D
T
P
T
F
F
F
G
M
R
N
G
E
T
V
E
I
E
I
D
K
G
K
R
L
I
I
K
L
E
T
I
S
E
P
D
E
N
G
N
R
T
I
Y
Y
A
M
N
G
Q
A
R
R
I
Y
I
K
D
E
N
V
H
T
N
A
N
V
K
P
K
A
D
K
S
N
P
S
H
I
G
A
Q
M
P
G
S
V
T
E
V
K
V
S
V
G
E
T
V
K
A
N
Q
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
V
I
K
Q
V
T
V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
E
--
10
PsiBlast_PDB
75.64
61%
-85
- C2 -
4HNV
5
?
A:
[26-1169]
--
Q
I
K
K
L
L
V
A
N
R
G
E
I
A
I
R
I
F
E
A
A
A
E
L
D
I
S
T
V
A
I
Y
S
N
E
D
K
S
S
L
H
R
Y
K
A
D
E
S
Y
L
V
G
S
D
L
G
P
A
E
S
Y
L
N
I
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R
I
I
D
V
A
K
Q
A
N
V
D
A
I
H
P
G
Y
G
F
L
S
E
N
E
Q
F
A
R
R
C
A
E
E
G
I
K
F
I
G
P
H
L
E
H
L
D
M
F
G
D
K
V
K
A
R
T
T
A
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K
A
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L
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-
I
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G
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-
Y
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L
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-
E
F
A
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E
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F
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L
M
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A
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-------
R
I
V
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E
E
S
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L
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A
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H
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A
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S
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A
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K
----
S
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--
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-
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E
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R
P
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A
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-
S
-
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-
S
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I
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D
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K
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L
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N
G
N
R
T
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Y
Y
A
M
N
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Q
A
R
R
I
Y
I
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D
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N
V
H
T
N
A
N
V
K
P
K
A
D
K
S
N
P
S
H
I
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A
Q
M
P
G
S
V
T
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V
K
V
S
V
G
E
T
V
K
A
N
Q
P
L
L
I
T
E
A
M
K
M
E
T
T
I
Q
A
P
F
D
G
V
I
K
Q
V
T
V
N
N
G
D
T
I
A
T
G
D
L
L
I
E
I
E
--
121
HHSearch
59.80
42%
-72
- C2 -
3OUZ
15
?
A:
[3-446]
A
M
E
I
K
S
I
L
I
A
N
R
G
E
I
A
L
R
A
L
R
T
I
K
E
M
G
K
K
A
I
C
V
Y
S
E
A
D
K
D
A
L
Y
L
K
Y
A
D
A
S
I
C
I
G
K
A
R
S
-
S
E
S
Y
L
N
I
P
A
I
I
A
A
A
E
I
A
E
A
D
A
I
F
P
G
Y
G
F
L
S
E
N
Q
N
F
V
E
I
C
A
K
H
N
I
K
F
I
G
P
S
V
E
A
M
N
L
M
S
D
K
S
K
A
K
Q
V
M
Q
R
A
G
V
P
V
-
I
P
G
S
D
G
A
L
A
G
-
A
E
A
A
K
-
K
L
A
K
E
I
G
Y
P
V
I
L
K
A
A
A
G
G
G
G
R
G
M
R
V
V
E
N
E
K
D
L
E
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A
Y
W
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A
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S
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A
M
T
A
F
G
D
G
T
M
Y
M
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K
Y
I
Q
N
P
R
H
I
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V
Q
V
I
G
D
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F
G
N
V
I
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V
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E
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D
C
S
M
Q
R
R
H
Q
K
L
I
E
E
S
P
A
I
L
L
D
E
K
T
R
T
R
L
H
E
T
A
I
K
A
A
K
A
I
G
Y
E
G
A
G
T
F
E
F
L
V
--
D
K
--
N
L
D
--
F
Y
F
I
E
M
N
T
R
L
Q
V
E
H
C
V
S
E
M
V
S
G
I
D
I
I
E
Q
M
I
K
V
A
E
G
Y
A
L
P
S
Q
--------
E
S
--
I
K
L
N
G
H
S
I
E
C
R
I
T
A
E
D
S
K
-
T
F
L
P
S
P
G
K
I
T
K
Y
I
P
P
A
G
R
N
V
R
M
E
S
-
H
C
Y
Q
D
Y
S
V
P
A
Y
Y
D
S
M
I
G
K
L
V
V
W
A
E
D
R
N
K
A
I
A
K
M
K
V
A
L
D
E
L
L
I
S
G
I
K
T
T
K
D
F
H
L
S
M
M
E
N
P
D
F
I
N
N
N
Y
D
T
N
Y
L
A
R
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
58.88
45%
-75
- C2 -
3JZF
1
ACCC_ECOLI
B:
[23-462]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
58.70
45%
-76
- C2 -
2V5A
2
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
58.65
45%
-75
- C2 -
2W6Z
2
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
58.54
45%
-76
- C2 -
2W6P
1
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
58.54
45%
-75
- C2 -
3JZI
1
ACCC_ECOLI
B:
[23-462]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
58.30
45%
-76
- C2 -
2W6N
2
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
58.27
45%
-75
- C2 -
2V58
2
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
58.25
45%
-75
- C2 -
2W6Q
2
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
58.02
45%
-76
- C2 -
2W70
2
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
57.97
45%
-78
- C2 -
2VR1
2
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
--
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
57.92
45%
-74
- C2 -
2W6M
2
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
57.92
45%
-75
- C2 -
2W71
2
ACCC_ECOLI
C:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
57.88
45%
-76
- C2 -
2W71
2
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
57.84
45%
-73
- C2 -
2VPQ
4
?
B:
[2-442]
----
K
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
V
G
P
T
L
S
K
-
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
-
V
P
G
S
D
G
L
M
K
D
-
V
S
E
A
K
-
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
E
M
G
N
A
A
V
R
A
A
K
A
V
N
Y
E
N
A
G
T
I
E
F
I
Y
--
D
L
--
N
-
D
NK
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
V
L
-------
P
Y
K
Q
E
D
--
I
K
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
F
M
P
S
P
G
K
I
E
Q
Y
L
A
P
G
G
Y
G
V
R
I
E
S
A
-
C
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
H
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
57.79
45%
-72
- C2 -
2V58
2
ACCC_ECOLI
B:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
57.74
45%
-73
- C2 -
2W6N
2
ACCC_ECOLI
B:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
57.70
45%
-75
- C2 -
2V59
1
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
57.69
45%
-76
- C2 -
2W6M
2
ACCC_ECOLI
B:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
57.66
44%
-76
- C2 -
3G8D
3
ACCC_ECOLI
B:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
A
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
57.61
44%
-76
- C2 -
3RV4
10
ACCC_ECOLI
A:
[5-444]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
E
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
57.57
45%
-77
- C2 -
2W6O
2
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
57.57
45%
-75
- C2 -
2W6Q
2
ACCC_ECOLI
B:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
57.54
45%
-78
- C2 -
2W6O
2
ACCC_ECOLI
C:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
57.39
45%
-75
- C2 -
3RUP
6
ACCC_ECOLI
B:
[5-444]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
57.37
45%
-72
- C2 -
3JZI
1
ACCC_ECOLI
A:
[23-462]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
57.30
45%
-69
- C2 -
2VPQ
4
?
A:
[2-445]
----
K
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
V
G
P
T
-
L
S
K
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
-
V
P
G
S
D
G
L
M
K
D
-
V
S
E
A
K
-
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
E
M
G
N
A
A
V
R
A
A
K
A
V
N
Y
E
N
A
G
T
I
E
F
I
Y
--
D
L
ND
N
-
K
--
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
V
L
P
Y
K
-------
Q
E
D
--
I
K
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
F
M
P
S
P
G
K
I
E
Q
Y
L
A
P
G
G
Y
G
V
R
I
E
S
-
A
C
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
H
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
Q
N
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
57.30
45%
-73
- C2 -
3G8C
4
ACCC_ECOLI
B:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
57.24
45%
-74
- C2 -
2V59
1
ACCC_ECOLI
B:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
57.22
45%
-74
- C2 -
2W70
2
ACCC_ECOLI
B:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
57.22
45%
-70
- C2 -
2VPQ
4
?
A:
[2-442]
----
K
K
V
L
I
A
N
R
G
E
I
A
V
R
I
I
R
A
C
R
D
L
G
I
Q
T
V
A
I
Y
S
E
G
D
K
D
A
L
H
T
Q
I
A
D
E
A
Y
C
V
G
P
T
L
S
K
-
D
S
Y
L
N
I
P
N
I
L
S
I
A
T
S
T
G
C
D
G
V
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
L
C
E
A
C
Q
L
K
F
I
G
P
S
Y
Q
S
I
Q
K
M
G
I
K
D
V
A
K
A
E
M
I
K
A
N
V
P
V
-
V
P
G
S
D
G
L
M
K
D
-
V
S
E
A
K
-
K
I
A
K
K
I
G
Y
P
V
I
I
K
A
T
A
G
G
G
G
K
G
I
R
V
A
R
D
E
K
E
L
E
T
G
F
R
M
T
E
Q
E
A
Q
T
A
F
G
N
G
G
L
Y
M
E
K
F
I
E
N
F
R
H
I
E
I
Q
I
V
G
D
S
Y
G
N
V
I
H
L
G
E
R
D
C
T
I
Q
R
R
M
Q
K
L
V
E
E
A
P
S
P
I
L
D
D
E
T
R
R
E
M
G
N
A
A
V
R
A
A
K
A
V
N
Y
E
N
A
G
T
I
E
F
I
Y
--
D
L
--
N
-
D
N
K
F
Y
F
M
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
V
T
G
I
D
L
V
K
L
Q
L
Q
V
A
M
G
D
V
L
-------
P
Y
K
Q
E
D
--
I
K
L
T
G
H
A
I
E
F
R
I
N
A
E
N
P
Y
K
N
F
M
P
S
P
G
K
I
E
Q
Y
L
A
P
G
G
Y
G
V
R
I
E
S
A
-
C
Y
T
N
Y
T
I
P
P
Y
Y
D
S
M
V
A
K
L
I
I
H
E
P
T
R
D
E
A
I
M
A
G
I
R
A
L
S
E
F
V
V
L
G
I
D
T
T
I
P
F
H
I
K
L
L
N
N
D
I
F
R
S
G
K
F
N
T
N
F
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
57.05
44%
-74
- C2 -
1DV2
1
ACCC_ECOLI
B:
[5-444]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
K
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
56.95
45%
-75
- C2 -
2J9G
3
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
--
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
56.90
45%
-73
- C2 -
3RUP
5
ACCC_ECOLI
A:
[5-444]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
56.76
44%
-67
- C2 -
2VQD
3
ACCC_PSEAE
A:
[2-441]
---
L
E
K
V
L
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
E
L
M
H
L
S
L
A
D
E
S
V
C
I
G
P
A
P
A
-
T
Q
S
Y
L
Q
I
P
A
I
I
A
A
A
E
V
T
G
A
T
A
I
H
P
G
Y
G
F
L
A
E
N
A
D
F
A
E
Q
I
E
R
S
G
F
T
F
V
G
P
T
A
E
V
I
R
L
M
G
D
K
V
S
A
K
D
A
M
K
R
A
G
V
P
T
-
V
P
G
S
D
G
P
L
P
E
-
D
E
E
T
A
L
A
I
A
R
E
V
G
Y
P
V
I
I
K
A
A
G
G
G
G
G
R
G
M
R
V
V
Y
D
E
S
E
L
I
K
S
A
K
L
T
R
T
E
A
G
A
A
F
G
N
P
M
V
Y
L
E
K
F
L
T
N
P
R
H
V
E
V
Q
V
L
S
D
G
Q
G
N
A
I
H
L
G
D
R
D
C
S
L
Q
R
R
H
Q
K
V
I
E
E
A
P
A
P
G
I
D
E
K
A
R
Q
E
V
F
A
R
C
V
Q
A
C
I
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
N
--
G
-
R
--
F
Y
F
I
E
M
N
T
R
V
Q
V
E
H
P
V
S
E
M
V
T
G
V
D
I
V
K
E
M
L
R
I
A
S
G
E
K
L
S
------
I
-
R
Q
E
D
--
V
V
I
R
G
H
A
L
E
C
R
I
N
A
E
D
P
-
K
T
F
M
P
S
P
G
K
V
K
H
F
H
A
P
G
G
N
G
V
R
V
D
S
-
H
L
Y
S
G
Y
S
V
P
P
N
Y
D
S
L
V
G
K
V
I
T
Y
G
A
D
R
D
E
A
L
A
R
M
R
N
A
L
D
E
L
I
V
D
G
I
K
T
N
T
E
L
H
K
D
L
V
R
D
A
A
F
C
K
G
G
V
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
56.76
45%
-76
- C2 -
3RV3
3
ACCC_ECOLI
B:
[5-444]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
56.66
44%
-75
- C2 -
1DV2
1
ACCC_ECOLI
A:
[5-444]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
K
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
56.65
45%
-76
- C2 -
3RV3
3
ACCC_ECOLI
A:
[5-444]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
56.32
45%
-76
- C2 -
2J9G
3
ACCC_ECOLI
B:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
--
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
---
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
55.82
45%
-73
- C2 -
3G8C
4
ACCC_ECOLI
A:
[2-441]
---
L
D
K
I
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
S
A
D
R
D
L
K
H
V
L
L
A
D
E
T
V
C
I
G
P
A
P
S
-
V
K
S
Y
L
N
I
P
A
I
I
S
A
A
E
I
T
G
A
V
A
I
H
P
G
Y
G
F
L
S
E
N
A
N
F
A
E
Q
V
E
R
S
G
F
I
F
I
G
P
K
A
E
T
I
R
L
M
G
D
K
V
S
A
I
A
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
L
G
D
D
M
D
K
N
R
-
A
I
A
K
R
I
G
Y
P
V
I
I
K
A
S
G
G
G
G
G
R
G
M
R
V
V
R
G
D
A
E
L
A
Q
S
I
S
M
T
R
A
E
A
K
A
A
F
S
N
D
M
V
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
G
Q
G
N
A
I
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
P
E
L
R
R
Y
I
G
E
R
C
A
K
A
C
V
D
I
G
Y
R
G
A
G
T
F
E
F
L
F
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
I
K
E
Q
L
R
I
A
A
G
-----
Q
P
L
S
I
--
K
Q
E
E
--
V
H
V
R
G
H
A
V
E
C
R
I
N
A
E
D
P
-
N
T
F
L
P
S
P
G
K
I
T
R
F
H
A
P
G
G
F
G
V
R
W
E
S
-
H
I
Y
A
G
Y
T
V
P
P
Y
Y
D
S
M
I
G
K
L
I
C
Y
G
E
N
R
D
V
A
I
A
R
M
K
N
A
L
Q
E
L
I
I
D
G
I
K
T
N
V
D
L
Q
I
R
I
M
N
D
E
N
F
Q
H
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
55.34
48%
-77
- C2 -
4RZQ
2
ACCC_HAEIN
A:
[22-461]
---
L
E
K
V
V
I
A
N
R
G
E
I
A
L
R
I
L
R
A
C
K
E
L
G
I
K
T
V
A
V
H
S
T
A
D
R
D
L
K
H
V
L
L
A
D
E
T
I
C
I
G
P
A
P
S
A
-
K
S
Y
L
N
I
P
A
I
I
A
A
A
E
V
T
G
A
D
A
I
H
P
G
Y
G
F
L
S
E
N
A
D
F
A
E
Q
V
E
R
S
G
F
T
F
I
G
P
T
A
D
V
I
R
L
M
G
D
K
V
S
A
I
K
A
M
K
K
A
G
V
P
C
-
V
P
G
S
D
G
P
-----
A
K
N
K
-
E
I
A
K
R
I
G
Y
P
I
I
I
K
----------
R
V
V
R
S
E
D
A
L
E
E
S
I
A
M
T
K
A
E
----------
Y
M
E
K
Y
L
E
N
P
R
H
V
E
I
Q
V
L
A
D
T
H
G
N
A
V
Y
L
A
E
R
D
C
S
M
Q
R
R
H
Q
K
V
V
E
E
A
P
A
P
G
I
T
E
E
V
R
R
D
I
G
S
R
C
A
N
A
C
V
E
I
G
Y
R
G
A
G
T
F
E
F
L
Y
--
E
N
--
G
-
E
--
F
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
T
E
M
I
T
G
V
D
L
V
K
E
Q
L
R
I
A
A
G
L
P
I
S
F
-------
K
Q
E
D
--
I
K
V
K
G
H
A
M
E
C
R
I
N
A
E
D
P
-
K
T
F
L
P
S
P
G
K
V
N
H
L
H
S
P
G
G
L
G
V
R
W
D
S
-
H
V
Y
G
G
Y
T
V
P
P
H
Y
D
S
M
I
A
K
L
I
T
Y
G
D
T
R
E
V
A
I
R
R
M
Q
N
A
L
S
E
T
I
I
D
G
I
K
T
N
I
P
L
H
E
L
I
L
E
D
E
N
F
Q
K
G
G
T
N
I
H
Y
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
50.11
37%
-69
- C2 -
3VA7
6
?
A:
[28-500]
K
K
P
F
E
T
V
L
I
A
N
R
G
E
I
A
V
R
I
M
K
T
L
K
R
M
G
I
K
S
V
A
V
Y
S
D
P
D
K
Y
S
Q
H
V
T
D
A
D
F
S
V
A
L
H
G
R
-
T
A
A
E
T
Y
L
D
I
D
K
I
I
N
A
A
K
K
T
G
A
Q
A
I
I
P
G
Y
G
F
L
S
E
N
A
D
F
S
D
R
C
S
Q
E
N
I
V
F
V
G
P
S
G
D
A
I
R
K
L
G
L
K
H
S
A
R
E
I
A
E
R
A
K
V
P
L
V
P
---------------------------------------------------------------------------
N
A
R
H
V
E
I
Q
M
M
G
D
G
F
G
K
A
I
A
I
G
E
R
D
C
S
L
Q
R
R
N
Q
K
V
I
E
E
T
P
A
P
N
L
P
E
A
T
R
A
K
M
R
A
A
S
E
R
L
G
S
L
L
K
Y
K
C
A
G
T
V
E
F
I
Y
--
D
E
QR
D
-
E
--
F
Y
F
L
E
V
N
A
R
L
Q
V
E
H
P
I
T
E
M
V
T
G
L
D
L
V
E
W
M
L
R
I
A
A
N
D
S
P
D
F
D
-------
N
T
K
--
I
E
V
S
G
A
S
I
E
A
R
L
Y
A
E
N
P
V
K
D
F
R
P
S
P
G
Q
L
T
S
V
S
F
P
S
W
--
A
R
V
D
T
-
W
V
K
K
G
T
N
V
S
A
E
Y
D
P
T
L
A
K
I
I
V
H
G
K
D
R
N
D
A
I
M
K
L
N
Q
A
L
N
E
T
A
V
Y
G
C
I
T
N
I
D
Y
L
R
S
I
A
S
S
K
M
F
K
E
A
K
V
A
T
K
V
L
D
S
----
F
D
Y
K
---
P
C
A
F
E
V
L
A
P
G
A
N
T
S
V
Q
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
49.76
38%
-72
- C2 -
3VA7
5
?
A:
[34-478]
------
V
L
I
A
N
R
G
E
I
A
V
R
I
M
K
T
L
K
R
M
G
I
K
S
V
A
V
Y
S
D
P
D
K
Y
S
Q
H
V
T
D
A
D
F
S
V
A
L
-
H
G
R
T
A
A
E
T
Y
L
D
I
D
K
I
I
N
A
A
K
K
T
G
A
Q
A
I
I
P
G
Y
G
F
L
S
E
N
A
D
F
S
D
R
C
S
Q
E
N
I
V
F
V
G
P
S
G
D
A
I
R
K
L
G
L
K
H
S
A
R
E
I
A
E
R
A
K
V
P
L
-
V
P
--------------------------------------------------------------------------
N
A
R
H
V
E
I
Q
M
M
G
D
G
F
G
K
A
I
A
I
G
E
R
D
C
S
L
Q
R
R
N
Q
K
V
I
E
E
T
P
A
P
N
L
P
E
A
T
R
A
K
M
R
A
A
S
E
R
L
G
S
L
L
K
Y
K
C
A
G
T
V
E
F
I
Y
DE
Q
R
--
D
-
E
--
F
Y
F
L
E
V
N
A
R
L
Q
V
E
H
P
I
T
E
M
V
T
G
L
D
L
V
E
W
M
L
R
I
A
A
N
D
S
--------
P
-
D
F
D
N
T
K
I
E
V
S
G
A
S
I
E
A
R
L
Y
A
E
N
P
V
K
D
F
R
P
S
P
G
Q
L
T
S
V
S
F
P
S
--
W
A
R
V
D
T
W
V
K
-
K
G
T
N
V
S
A
E
Y
D
P
T
L
A
K
I
I
V
H
G
K
D
R
N
D
A
I
M
K
L
N
Q
A
L
N
E
T
A
V
Y
G
C
I
T
N
I
D
Y
L
R
S
I
A
S
S
K
M
F
K
E
A
K
V
A
T
K
V
L
D
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------