@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1100: (2016-03-21 )
MSKASKQTTYRVDGMSCTNCAGKFEKNVKNLEGVTDAKVNFGAGKISVYGETSISQIEKAGAFENLRVTDEKDYSSKPAKKESFLKKNWHLVVSIIFIILAFISQNISGEDSTTTIILYVIAIVVGGFNLFKEGFANLIKLDFTMESLMTIAIIGASIIGEWAEGSIVVILFAFSEVLERYSMDKARQSIRSLMDIAPKEALIRRDDVEQMIAVSDIQIGDIMIIKPGQKIAMDGVVIKGYSAINQSAITGESIPVEKKVDDEVFAGTLNEEGLLEVKVTKHVEDTTISKIIHLVEEAQGERAPAQAFVDKFAKYYTPTIMLIALLVVVVPPLFFGGDWDTWVYQGLSLLVVGCPCSLVISTPVSIVSAIGNSAKNGVLVKGGIYLEEIGGLQAIAFDKTGTLTKGKPVVTDFIPYSEHMDEQNSLSIITALETMSQHPLASAIISKAMIDNVDYKSIEIDNFSSITGKGVKGEVNGITYYIGSSKLFESSLEKSQSISQTYQSLQKQGKTAMLFGTESNILAIIAVADEVRESSKEVIAQLHKLGIAHTIMLTGDNNDTAQFIGKEIGVSDIKAELMPEDKLTYIKELKQTYGKVAMIGDGVNDAPALAASTVGIAMGGAGTDTALETADVALMGDDLKKLPFIVNLSRKTLKIIKQNITFSLGIKLLALLLVLPGWLTLWIAIVADMGATLLVTLNGLRLMKVKK
Atome Classification :
(30 SA)
.........10........20........30........40........50......-..60......---------..70........80........-90........100----.-.-----....-.110.......120...-....130.......140--.......150.----......160------------..----------.-----------------------.---------....170.....-------------..180.......190.......200........210.......--220.......230......--.240-.---.......250.......260---------..-------------......270.......280.......290.......300.......310.......320.----..------....330-----...-----.-.....----340.......350......--.360.......370.......380.......390.......400.......410.......420-----------------.---..--------------.---....430--------------------.-----------------.---.---.----------------....--------------------.440.......-----450--------------------------------------------...------.-----...460-........470----------------------.------..-.----.----.------.--.----.480.......490-.-------.---------.----.....500.......510-------......------------------------.-----.------------------------520-----------------------.........530.......540.......550.......560.......570----------------------------------------.-----------------------------------------------------.-----------------------------------------------------......----------------------.580.......590.......600.......610.......620.......630.......640.......650.......660.-----......670...------...-------.-.680---------.........690.......--700.......-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSKASKQ
T
T
Y
R
VDGMSC
T
N
C
A
G
K
F
E
K
N
V
K
NLEGVTD
A
K
V
NFGA
G
K
I
S
V
Y
GE
T
S
I
S
Q
I
-
E
KAGAFEN
L
R
---------VTDEKDYSSKP
A
K
K
E
S
F
L
K
KN
W
-
H
L
V
V
S
I
I
F
I
I
L
A
F
----
I
-S-----QNIS-GEDS
T
T
T
I
I
L
Y
V
I
A
I
V
V-G
G
F
N
L
F
K
E
G
F
A
N
L
I
K
L
D
--
F
T
M
E
S
L
M
T
I
A
I
----
I
G
A
S
I
I
G
E-------------WA----------E-----------------------G---------
S
I
V
V
I
L
F
A
F
S
E
V
-------------
L
E
R
Y
S
M
D
K
A
R
Q
S
I
R
S
L
M
DIA
P
K
E
A
-
L
I
R
R
D
D
V
E
Q
M
I
A
V
S
D
I
Q
I--G
D
I
M
I
IKPG
Q
K
I
AMD
G
V
V
I
--
K
G
Y--S---AINQSAITGESIPVEKKVD----------D
E
-------------
V
FAGTLNEE
G
L
L
E
V
K
V
TKHVE
D
T
T
I
S
K
I
I
H
L
V
E
E
AQGERA
P
A
Q
A
F
V
D
K
F
A
K
YY
T
P
T
I
M
L
I
----
A
L
------
L
V
V
VV-------
P
P
L
-----F-FGGD
W
----
D
T
W
V
YQG
L
S
L
L
V
VGCP
C
S
L
--
V
IS
T
P
V
S
I
V
S
A
I
GNSAKN
G
V
L
V
KG
G
I
Y
L
EEIGG
L
Q
A
I
A
FDKTGTLTKGKP
V
V
T
DFIP
Y
S
E
HMD------------------E---QN--------------S---L
S
I
I
T
----------------------
A
-----------------
L
---
E
---
T
----------------
M
S
QH--------------------
P
L
A
S
A
I
I
S
K
A
M
-----IDN--------------------------------------------VD
Y
------
K
-----
S
I
E
ID--NFSSITGKG------------------------V------
K
G
-E----V----N------
G
--
I
----
T
Y
Y
IG
S
S
K
L
F
E
S
-
S
-
L
-------
E
---------
K
----
S
Q
S
I
S
Q
T
Y
Q
S
L
Q
KQG
K
T
--------
A
M
L
F
GT------------------------E-----S------------------------
N
-------------------------
I
L
A
I
I
A
V
A
D
E
V
R
E
S
S
K
E
V
I
A
Q
L
H
KLG
I
A
H
T
I
M
L
TGDNN
D
T
A
Q
F
I
G
K
EI
G
V
------------------------------------------
S
-----------------------------------------------------
D
-----------------------------------------------------
I
K
A
ELM----------------------PE
D
K
L
T
Y
I
K
E
L
K
Q
T
YG
K
V
A
M
IGDGVNDA
P
A
L
A
A
S
T
V
G
I
AMGGAGTDTALETA
D
V
A
LMG
D
D
L
K
KL
P
F
I
V
NL
S
R
K
T
L
K
I
I
K
Q
NI
T
F
S
-----
L
G
I
K
L
L
A
-
L
L
L
V------LP
G
-------
W
-
L
T
-----------
L
W
I
A
I
V
A
DMG
A
T
L
L
V
T
LN
G
--
L
--
R
L
M
KVKK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
85.64
33%
-90
- C3 -
3RFU
3
?
A:
[74-736]
--------------------------------------------------------------------------------------
V
S
P
E
Y
L
D
M
R
R
R
F
W
-
I
A
L
M
L
T
I
P
V
V
I
L
E
----
M
-
G
GHGLK
H
F
I
S
-
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
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G
W
Q
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L
K
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--
L
N
M
F
T
L
I
A
M
G
I
----
G
V
A
W
I
Y
S
M
-------------
V
A
----------
V
L
WPGVFPHAFRSQEGVVAVY
F
E
A
A
---------
A
V
I
T
T
L
V
L
L
G
Q
V
-------------
L
E
L
K
A
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----------
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-------------
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----
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-------
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A
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-----
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P
Q
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----
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--
D
D
F
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------------------
E
---
D
N
--------------
A
---
L
A
L
A
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----------------------
A
-----------------
L
---
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---
H
----------------
Q
S
E
H
--------------------
P
L
A
N
A
I
V
H
A
A
K
-----
E
K
G
--------------------------------------------
L
S
L
------
G
-----
S
V
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----
A
F
E
A
P
T
G
K
G
------------------------
V
------
V
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-
Q
----
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----
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------
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--
H
----
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V
A
I
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M
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H
-
G
-------
G
---------
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----
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A
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K
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--------
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------------------------
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-----
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------------------------
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-------------------------
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V
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D
P
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Q
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-
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D
S
K
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T
A
E
A
V
A
G
T
L
G
I
------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
----------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
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D
I
G
I
A
M
G
T
-
G
T
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V
A
I
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S
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T
L
L
H
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D
L
R
G
I
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K
A
R
R
L
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T
M
S
N
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R
Q
N
L
F
F
A
-----
F
I
Y
N
V
L
G
-
V
P
L
A
A
GVLYP
L
T
G
-------
L
L
L
S
-----------
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
--
L
--
R
L
K
R
V
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.56
37%
-95
- C3 -
4UMW
2
?
A:
[124-730]
---------------------------------------------------------------------------------------------
R
L
K
E
N
L
-
P
L
---
I
T
L
I
V
M
M
A
----
I
-
S
-----
W
G
L
E
-
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
-
G
L
Y
P
I
A
R
Q
A
L
-
R
L
I
K
S
G
SY
F
A
I
E
T
L
M
S
V
A
A
----
I
G
A
L
F
I
G
A
-------------
T
A
----------
E
-----------------------
A
---------
A
M
V
L
L
L
F
L
I
G
E
R
-------------
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
-
T
R
L
R
N
G
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R
E
E
V
A
I
N
S
L
R
P
--
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
--
S
P
F
--
A
---
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
-------------
V
P
A
G
A
T
S
V
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R
L
V
T
L
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V
L
S
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P
G
A
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A
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D
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R
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A
V
----
A
L
------
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V
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L
V
-------
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P
L
-----
L
-
F
A
A
S
W
----
Q
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W
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----------------------
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---
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----------------
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H
--------------------
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Q
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R
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A
Q
-----
V
A
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--------------------------------------------
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A
I
------
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A
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----
S
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R
A
L
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G
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G
------------------------
I
------
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----
V
----
N
------
G
--
E
----
R
V
L
I
C
A
-----
A
-
G
-
K
-------
H
---------
P
----
A
D
A
F
A
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L
I
N
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L
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S
A
G
Q
T
--------
V
V
L
V
V
R
------------------------
N
-----
D
------------------------
D
-------------------------
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
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S
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L
N
A
L
G
V
-
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
----------------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
-
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
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M
K
A
A
A
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G
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A
M
-
G
S
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T
D
V
A
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A
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H
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H
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L
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Q
M
I
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L
A
R
A
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A
N
I
R
Q
N
I
T
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A
-----
L
G
L
K
G
I
F
-
L
V
T
T
------
L
L
G
-------
M
-
T
G
-----------
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
--
L
--
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
84.95
32%
-96
- C3 -
4BYG
4
?
A:
[83-734]
-----------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
GGHG
L
-
K
-----
H
F
I
S
-
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
--
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
-------------
W
P
GVFPHAFRSQ
E
-----------------------
G
VVAVY
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
-------------
L
E
L
K
A
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S
A
I
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A
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L
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L
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P
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K
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A
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----
A
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------
L
S
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I
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W
A
L
L
GPQ
P
A
L
-----
S
-
Y
G
----------
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
--
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
V
--
T
D
D
F
V
------------------
E
---
D
N
--------------
A
---
L
A
L
A
A
----------------------
A
-----------------
L
---
E
---
H
----------------
Q
S
E
H
--------------------
P
L
A
N
A
I
V
H
A
A
K
-----
E
K
G
--------------------------------------------
L
S
L
------
G
-----
S
V
E
----
A
F
E
A
P
T
G
K
G
------------------------
V
------
V
G
-
Q
----
V
----
D
------
G
--
H
----
H
V
A
I
G
N
A
R
L
M
Q
E
-
H
-
G
-------
G
---------
D
----
N
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
--------
V
M
F
M
A
V
------------------------
D
-----
G
------------------------
K
-------------------------
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
----------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
------
L
T
G
L------
L
-
L
S
-----------
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
--
L
--
R
L
K
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
84.78
30%
-82
- C3 -
3J09
-
COPA_ARCFU
A:
[15-729]
----
P
M
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
E
T
A
F
I
R
F
D
E
K
R
I
---
D
F
E
T
I
K
R
V
I
E
D
L
-------
G
Y
G
V
V
D
E
Q
A
A
V
S
A
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
---
L
A
H
-----
F
I
S
L
-
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
-
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
--
L
N
M
D
V
M
Y
S
M
G
V
----
G
A
A
F
L
A
S
V
L
STAGVLPREYSF
Y
E
----------
T
-----------------------
S
---------
V
L
L
L
A
F
L
L
L
G
R
T
-------------
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
D
G
K
E
I
A
V
P
V
E
E
V
A
V
--
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
--
E
G
E
--
S
---
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
-------------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
----
A
I
------
S
A
F
I
Y
-------
W
Y
F
-----
I
-
A
H
A
P
L
----
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
--
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
--
G
D
------------------
E
---
R
E
--------------
L
---
L
R
L
A
A
----------------------
I
-----------------
A
---
E
---
R
----------------
R
S
E
H
--------------------
P
I
A
E
A
I
V
K
K
A
L
-----
E
H
G
--------------------------------------------
I
E
L
-------------
G
E
P
E
--
K
V
E
V
I
A
G
E
G
------------------------
V
------
V
A
---------------------
D
----
G
I
L
V
G
N
K
R
L
M
E
D
-
F
G
V
-------
A
---------
V
----
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
--------
A
V
I
V
A
R
------------------------
N
-----
G
------------------------
R
-------------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
----------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
-----
L
I
Y
N
V
I
L
-
I
P
A
A
------
A
G
L
L
Y
P
IFGV
V
-
F
R
-----------
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
--
L
--
L
L
R
N
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
84.74
37%
-77
- C3 -
4UMW
2
?
A:
[124-730]
----------------------
R
L
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
F
N
-----------
H
P
F
G
Q
L
A
F
I
A
---------
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
--------------------------------------------------------------------
F
A
I
E
T
L
M
S
V
A
A
----
I
G
A
L
F
I
G
A
-------------
T
A
----------
E
-----------------------
A
---------
A
M
V
L
L
L
F
L
I
G
E
R
-------------
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
-
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
--
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
--
S
P
F
--
A
---
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
-------------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
----
A
L
------
L
V
T
L
V
-------
P
P
L
-----
L
-
F
A
A
S
W
----
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
--
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
-
A
T
G
I
S
------------------
E
---
S
E
--------------
L
---
L
T
L
A
A
----------------------
A
-----------------
V
---
E
---
Q
----------------
G
A
T
H
--------------------
P
L
A
Q
A
I
V
R
E
A
Q
-----
V
A
E
--------------------------------------------
L
A
I
------
P
-----
T
A
E
----
S
Q
R
A
L
V
G
S
G
------------------------
I
------
E
A
-
Q
----
V
----
N
------
G
--
E
----
R
V
L
I
C
A
A
------
G
-
K
-------
H
---------
P
----
A
D
A
F
A
G
L
I
N
E
L
E
S
A
G
Q
T
--------
V
V
L
V
V
R
------------------------
N
-----
D
------------------------
D
-------------------------
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
-
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
----------------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
-
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
S
-
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
-----
L
G
L
K
G
I
F
-
L
V
T
T
------
L
L
G
-------
M
-
T
G
-----------
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
--
L
--
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.16
32%
-93
- C3 -
3RFU
3
?
A:
[83-734]
-----------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
GHG
L
-
K
-----
H
F
I
S
-
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
--
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
-------------
W
P
GVFPHAFRSQ
E
-----------------------
G
VVAVY
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
-------------
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
--
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
--
E
G
R
--
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
----
A
V
------
L
S
F
I
V
W
A
L
LGPQ
P
A
L
-----
S
-
Y
G
----------
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
--
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
V
--
T
D
D
F
V
------------------
E
---
D
N
--------------
A
---
L
A
L
A
A
----------------------
A
-----------------
L
---
E
---
H
----------------
Q
S
E
H
--------------------
P
L
A
N
A
I
V
H
A
A
K
-----
E
K
G
--------------------------------------------
L
S
L
------
G
-----
S
V
E
----
A
F
E
A
P
T
G
K
G
------------------------
V
------
V
G
-
Q
----
V
----
D
------
G
--
H
----
H
V
A
I
G
N
A
R
L
M
Q
E
-
H
-
G
-------
G
---------
D
----
N
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
--------
V
M
F
M
A
V
------------------------
D
-----
G
------------------------
K
-------------------------
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
----------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
------
L
T
G
L------
L
-
L
S
-----------
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
--
L
--
R
L
K
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
84.07
32%
-95
- C3 -
4BEV
2
?
A:
[83-734]
-----------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
GGHG
L
-
K
-----
H
F
I
S
-
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
--
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
-------------
W
P
GVFPHAFRSQ
E
-----------------------
G
VVAVY
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
-------------
L
E
L
K
A
R
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Q
T
G
S
A
I
R
A
L
L
K
L
V
P
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V
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--
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L
L
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R
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---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
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S
F
V
M
K
A
L
H
V
G
S
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L
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V
S
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R
L
A
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W
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I
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V
----
A
V
------
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W
A
L
L
GPQ
P
A
L
-----
S
-
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G
----------
L
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V
L
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C
P
C
A
L
--
G
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A
L
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V
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T
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V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
V
--
T
D
D
F
V
------------------
E
---
D
N
--------------
A
---
L
A
L
A
A
----------------------
A
-----------------
L
---
E
---
H
----------------
Q
S
E
H
--------------------
P
L
A
N
A
I
V
H
A
A
K
-----
E
K
G
--------------------------------------------
L
S
L
------
G
-----
S
V
E
----
A
F
E
A
P
T
G
K
G
------------------------
V
------
V
G
-
Q
----
V
----
D
------
G
--
H
----
H
V
A
I
G
N
A
R
L
M
Q
E
-
H
-
G
-------
G
---------
D
----
N
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
--------
V
M
F
M
A
V
------------------------
D
-----
G
------------------------
K
-------------------------
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
----------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
------
L
T
G
L------
L
-
L
S
-----------
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
--
L
--
R
L
K
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.84
32%
-93
- C3 -
3RFU
3
?
B:
[83-734]
-----------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
GGHG
L
-
K
-----
H
F
I
S
-
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
--
L
N
M
F
T
L
I
A
M
G
I
GVAW
I
Y
S
M
V
A
V
L
-------------
W
P
GVFPHAFRSQ
E
-----------------------
G
VVAVYFEAA
A
V
I
T
T
L
V
L
L
G
Q
V
-------------
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
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K
E
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S
E
E
E
V
S
L
D
N
V
A
V
--
G
D
L
L
R
V
R
P
G
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K
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D
G
E
V
Q
--
E
G
R
--
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
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M
L
A
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S
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R
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R
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L
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T
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S
G
W
F
V
P
A
V
I
L
V
----
A
V
------
L
S
F
I
V
WALLGPQ
P
A
L
-----
S
-
Y
G
----------
L
I
A
A
V
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V
L
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I
A
C
P
C
A
L
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G
L
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V
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N
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M
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L
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G
H
P
K
L
T
R
I
V
--
T
D
D
F
V
------------------
E
---
D
N
--------------
A
---
L
A
L
A
A
----------------------
A
-----------------
L
---
E
---
H
----------------
Q
S
E
H
--------------------
P
L
A
N
A
I
V
H
A
A
K
-----
E
K
G
--------------------------------------------
L
S
L
------
G
-----
S
V
E
----
A
F
E
A
P
T
G
K
G
------------------------
V
------
V
G
-
Q
----
V
----
D
------
G
--
H
----
H
V
A
I
G
N
A
R
L
M
Q
E
-
H
-
G
-------
G
---------
D
----
N
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
--------
V
M
F
M
A
V
------------------------
D
-----
G
------------------------
K
-------------------------
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
----------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
FIYNV
L
G
V
P
L
A
A
G
V
L
Y
P
------
L
T
G
L------
L
-
L
S
-----------
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
--
L
--
R
L
K
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
83.81
32%
-93
- C3 -
3RFU
3
?
C:
[83-734]
-----------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
GGHG
L
-
K
-----
H
F
I
S
-
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
--
L
N
M
F
T
L
I
A
M
G
I
GVAW
I
Y
S
M
V
A
V
L
-------------
W
P
GVFPHAFRSQ
E
-----------------------
G
VVAVYFEAA
A
V
I
T
T
L
V
L
L
G
Q
V
-------------
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
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L
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V
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--
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L
L
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E
V
Q
--
E
G
R
--
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
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M
V
S
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A
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R
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R
A
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R
L
A
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T
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G
W
F
V
P
A
V
I
L
V
----
A
V
------
L
S
F
I
V
WALLGPQ
P
A
L
-----
S
-
Y
G
----------
L
I
A
A
V
S
V
L
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I
A
C
P
C
A
L
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H
P
K
L
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V
--
T
D
D
F
V
------------------
E
---
D
N
--------------
A
---
L
A
L
A
A
----------------------
A
-----------------
L
---
E
---
H
----------------
Q
S
E
H
--------------------
P
L
A
N
A
I
V
H
A
A
K
-----
E
K
G
--------------------------------------------
L
S
L
------
G
-----
S
V
E
----
A
F
E
A
P
T
G
K
G
------------------------
V
------
V
G
-
Q
----
V
----
D
------
G
--
H
----
H
V
A
I
G
N
A
R
L
M
Q
E
-
H
-
G
-------
G
---------
D
----
N
A
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
--------
V
M
F
M
A
V
------------------------
D
-----
G
------------------------
K
-------------------------
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
-
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
----------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
FIYNV
L
G
V
P
L
A
A
G
V
L
Y
P
------
L
T
G
L------
L
-
L
S
-----------
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
--
L
--
R
L
K
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.77
32%
-93
- C3 -
3RFU
3
?
D:
[83-734]
-----------------------------------------------------------------------------------------------
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
GGHG
L
-
K
-----
H
F
I
S
-
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
--
L
N
M
F
T
L
I
A
M
G
I
GVAW
I
Y
S
M
V
A
V
L
-------------
W
P
GVFPHAFRSQ
E
-----------------------
G
VVAVYFEAA
A
V
I
T
T
L
V
L
L
G
Q
V
-------------
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
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A
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L
D
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--
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L
L
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E
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Q
--
E
G
R
--
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
-------------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
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R
S
R
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Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
----
A
V
------
L
S
F
I
V
WALLGPQ
P
A
L
-----
S
-
Y
G
----------
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
--
G
L
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------------------
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---
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--------------
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---
L
A
L
A
A
----------------------
A
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---
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---
H
----------------
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S
E
H
--------------------
P
L
A
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A
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H
A
A
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-----
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G
--------------------------------------------
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S
L
------
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-----
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----
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A
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G
------------------------
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------
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G
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----
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--
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----
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A
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-------
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----
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A
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L
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K
A
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L
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G
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--------
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M
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M
A
V
------------------------
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-----
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------------------------
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-------------------------
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A
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L
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M
L
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G
D
S
K
R
T
A
E
A
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A
G
T
L
G
I
------------------------------------------
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
----------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
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L
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A
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L
F
F
A
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L
G
V
P
L
A
A
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V
L
Y
P
------
L
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L------
L
-
L
S
-----------
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
--
L
--
R
L
K
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.00
37%
-88
- C3 -
4UMV
2
?
A:
[126-730]
-----------------------------------------------------------------------------------------------
K
E
N
L
-
P
L
---
I
T
L
I
V
M
M
A
----
I
-
S
-----
W
G
L
E
-
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
-
G
L
Y
P
I
A
R
Q
A
L
-
R
L
I
K
S
G
SY
F
A
I
E
T
L
M
S
V
A
A
----
I
G
A
L
F
I
G
A
-------------
T
A
----------
E
-----------------------
A
---------
A
M
V
L
L
L
F
L
I
G
E
R
-------------
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
M
A
L
K
P
E
T
A
-
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
--
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
--
S
P
F
--
A
---
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
-------------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
----
A
L
------
L
V
T
L
V
-------
P
P
L
-----
L
-
F
A
A
S
W
----
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
--
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
A
T
-
G
I
S
------------------
E
---
S
E
--------------
L
---
L
T
L
A
A
----------------------
A
-----------------
V
---
E
---
Q
----------------
G
A
T
H
--------------------
P
L
A
Q
A
I
V
R
E
A
Q
-----
V
A
E
--------------------------------------------
L
A
I
------
P
-----
T
A
E
----
S
Q
R
A
L
V
G
S
G
------------------------
I
------
E
A
-
Q
----
V
----
N
------
G
--
E
----
R
V
L
I
C
A
-----
A
-
G
-
K
-------
H
---------
P
----
A
D
A
F
A
G
L
I
N
E
L
E
S
A
G
Q
T
--------
V
V
L
V
V
R
------------------------
N
-----
D
------------------------
D
-------------------------
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
-
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
----------------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
-
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
-
G
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
-----
L
G
L
K
G
I
F
-
L
V
T
T
------
L
L
G
-------
M
-
T
G
-----------
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
--
L
--
R
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.50
32%
-72
- C3 -
3J09
-
COPA_ARCFU
A:
[17-680]
------
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
-------
E
T
A
F
I
R
F
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
D
L
G
Y
G
V
V
D
E
Q
A
A
V
S
A
E
V
E
H
L
S
R
M
K
R
K
L
-
Y
-
V
A
A
F
A
G
V
L
L
L
F
----
L
-
A
-----
H
F
I
S
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
-
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
--
L
N
M
D
V
M
Y
S
M
G
V
----
G
A
A
F
L
A
S
V
-------------
L
S
----------
T
-----------------------
A
---------
G
V
L
P
R
E
Y
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
D
G
K
E
I
A
V
P
V
E
E
V
A
V
--
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
--
E
G
E
--
S
---
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
-------------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
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K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
----
A
I
S
A
F
I
YW
Y
F
I
A
H
-------
A
P
L
-----
L
-
F
A
--
F
----
T
T
L
I
----
A
V
L
V
V
A
C
P
C
A
F
--
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
--
N
G
D
------------------
E
---
R
E
--------------
L
---
L
R
L
A
A
----------------------
I
-----------------
A
---
E
---
R
----------------
R
S
E
H
--------------------
P
I
A
E
A
I
V
K
K
A
L
-----
E
H
G
--------------------------------------------
I
E
L
------
G
-------
E
P
E
--
K
V
E
V
I
A
G
E
G
------------------------
V
------
V
A
-----------
D
------
G
--
I
------
L
V
G
N
K
R
L
M
E
D
F
G
-
V
-------
A
---------
V
----
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
--------
A
V
I
V
A
R
------------------------
N
-----
G
------------------------
R
-------------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
-
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
----------------------
P
H
Q
K
S
E
E
V
K
K
L
-
Q
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
-----
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
76.06
32%
-82
- C3 -
3J08
-
COPA_ARCFU
A:
[122-729]
----------------------------------------------------------------------------------------------------------------------------------
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
-
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
--
L
N
M
D
V
M
Y
S
M
G
V
----
G
A
A
F
L
A
S
V
L
S
T
A
GVLPREYSF
Y
E
----------
T
-----------------------
S
---------
V
L
L
L
A
F
L
L
L
G
R
T
-------------
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
D
G
K
E
I
A
V
P
V
E
E
V
A
V
--
G
D
I
V
I
V
R
P
G
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K
I
P
V
D
G
V
V
V
--
E
G
E
--
S
---
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
-------------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
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A
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P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
----
A
I
------
S
A
F
I
Y
-------
W
Y
F
-----
I
-
A
H
A
P
L
----
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
--
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
--
G
D
------------------
E
---
R
E
--------------
L
---
L
R
L
A
A
----------------------
I
-----------------
A
---
E
---
R
----------------
R
S
E
H
--------------------
P
I
A
E
A
I
V
K
K
A
L
-----
E
H
G
--------------------------------------------
I
E
L
-------------
G
E
P
E
--
K
V
E
V
I
A
G
E
G
------------------------
V
------
V
A
---------------------
D
----
G
I
L
V
G
N
K
R
L
M
E
D
-
F
G
V
-------
A
---------
V
----
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
--------
A
V
I
V
A
R
------------------------
N
-----
G
------------------------
R
-------------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
----------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
-----
L
I
Y
N
V
I
L
-
I
P
A
A
------
A
G
L
L
Y
P
IFGV
V
-
F
R
-----------
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
--
L
--
L
L
R
N
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.27
33%
-74
- C3 -
3J08
-
COPA_ARCFU
A:
[96-680]
--------------------------------------------------------------------------------------------
S
R
M
K
R
K
L
-
Y
-
V
A
A
F
A
G
V
L
L
L
F
----
L
-
A
-----
H
F
I
S
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
-
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
--
L
N
M
D
V
M
Y
S
M
G
V
----
G
A
A
F
L
A
S
V
-------------
L
S
----------
T
-----------------------
A
---------
G
V
L
P
R
E
Y
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
D
G
K
E
I
A
V
P
V
E
E
V
A
V
--
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
--
E
G
E
--
S
---
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
-------------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
----
A
I
S
A
F
IYW
Y
F
I
A
H
-------
A
P
L
-----
L
-
F
A
--
F
----
T
T
L
I
----
A
V
L
V
V
A
C
P
C
A
F
--
G
L
A
T
P
T
A
L
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V
G
M
G
K
G
A
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L
G
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L
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N
A
D
A
L
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V
A
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V
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K
T
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L
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T
D
L
V
P
L
--
N
G
D
------------------
E
---
R
E
--------------
L
---
L
R
L
A
A
----------------------
I
-----------------
A
---
E
---
R
----------------
R
S
E
H
--------------------
P
I
A
E
A
I
V
K
K
A
L
-----
E
H
G
--------------------------------------------
I
E
L
------
G
-------
E
P
E
--
K
V
E
V
I
A
G
E
G
------------------------
V
------
V
A
-----------
D
------
G
--
I
------
L
V
G
N
K
R
L
M
E
D
F
G
-
V
-------
A
---------
V
----
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
--------
A
V
I
V
A
R
------------------------
N
-----
G
------------------------
R
-------------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
-
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
----------------------
P
H
Q
K
S
E
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K
L
-
Q
A
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-
G
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V
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Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
-----
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
72.05
22%
-65
- C3 -
2ZXE
5
?
A:
[137-793]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----------------------
G
---------
V
V
L
S
T
V
V
I
V
T
G
C
-------------
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
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A
-
L
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--
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A
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C
---
K
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L
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S
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R
S
P
E
FSSENPLETR
N
I
-------------
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
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----
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------
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F
F
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L
-------
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L
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-----
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--
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----
L
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L
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A
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A
DTTENQSGAAFDKTS
A
T
W
---
S
A
--------------
L
---
S
R
I
A
A
----------------------
L
-----------------
C
---
N
---
R
A
V
F
Q
A
GQDNVPILKRS
V
A
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D
--------------------
A
S
E
S
A
L
L
K
C
I
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-----
L
C
C
--------------------------------------------
G
S
V
------
Q
G
M
R
D
R
N
P
K
I
V
--
E
I
P
F
N
S
T
N
K
Y
-----------------------
Q
------
L
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-
I
----
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----
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NEKSSE
S
R
Y
L
----
L
V
M
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G
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I
L
D
-
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-------
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ILLNG
A
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L
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M
K
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A
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N
A
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L
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L
G
G
L
G
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R
--------
V
L
G
F
C
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ALPEDKYNEG
Y
P
F
D
ADEPNFPTT
D
-----
L
------------------------
C
-------------------------
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
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A
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-
V
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M
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A
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A
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G
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G
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------------------------------------------
I
-----------------------------------------------------
S
EGNET
I
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D
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L
NIPIGQVNPRDAK
A
C
V
V
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V
F
A
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----------------------
P
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L
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F
D
N
L
K
K
S
I
A
Y
T
-----
L
T
S
N
I
P
E
-
I
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Fugue
71.48
20%
-66
- C3 -
3B8E
6
AT1A1_PIG
A:
[1-998]
-----
A
K
K
E
R
D
M
D
E
L
K
K
E
V
S
M
D
D
H
K
L
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L
D
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L
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K
Y
G
T
D
L
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-----
L
T
P
A
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A
A
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L
-
A
R
D
G
-----------------
P
N
A
L
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P
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W
V
K
F
C
R
Q
L
-
F
G
G
F
S
M
L
L
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A
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----
L
-
C
-----
F
L
A
Y
-
G
I
Q
A
A
T
E
----------------------------------------------
E
E
P
Q
N
D
N
-------------
L
Y
----------
L
-----------------------
G
---------
V
V
L
S
A
V
V
I
I
T
G
C
-------------
F
S
Y
Y
Q
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K
N
M
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L
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--
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--
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A
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C
---
K
V
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N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
----------
F
T
N
ENPLETRNI---
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
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M
G
R
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L
A
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L
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A
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F
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V
A
V
F
L
----
G
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------
S
F
F
I
--------
L
S
L
-----
I
-
L
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Y
T
W
----
L
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A
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L
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M
W
S
D
N
Q
I
H
E
------------------
A
---
D
T
TENQSGVSFDKTS
A
T
---
W
L
A
L
S
----------------------
R
-----------------
I
---
A
---
G
----------------
L
C
N
R
A
V
F
Q
A
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R
A
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A
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A
S
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S
A
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L
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L
CCGS
V
K
E
--------------------------------------------
M
R
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------
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-----
Y
T
K
I
V
--
E
I
P
F
N
S
T
N
K
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Q
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PNTAEPR
H
L
L
V
-----
M
------
K
G
-
A
----
P
----
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------
R
--
I
L
D
R
C
S
S
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L
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G
K
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Q
P
L
-
D
-
E
-------
E
---------
L
----
K
D
A
F
Q
N
A
Y
L
E
L
G
G
L
G
E
R
--------
V
L
G
F
C
H
------------------------
L
-----
F
L
P
DEQFPEGF
Q
F
D
T
DDVNFPLDN
L
C
-------------------------
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
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C
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A
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E
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IAARLNIPVSQVNPRDAK
A
C
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S
D
L
K
D
MT
S
E
-----------------------------------------------------
Q
-----------------------------------------------------
L
D
D
I
L
K
YHTEIVFARTS-----------
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
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V
A
V
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L
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A
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-----
L
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N
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-
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T
P
F
------
L
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F
-------
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-
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A
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T
V
T
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L
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G
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F
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G
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R
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N
WDDRWINDVEDSYG
Q
Q
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T
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C
H
T
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F
V
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A
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K
I
L
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G
L
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E
T
A
L
A
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L
S
Y
CPGMGVA
L
R
M
Y
P
LKPTWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY
65
Fugue
64.78
22%
-67
- C1 -
1SU4
3
AT2A1_RABIT
A:
[1-994]
M
E
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
----------
G
V
S
E
T
T
G
L
T
P
D
Q
V
---
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
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-
E
G
K
S
L
W
E
L
V
-----------------------------------------------------------------------------------
I
E
Q
F
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L
L
V
R
I
L
L
L
A
--
A
C
I
S
F
V
L
A
W
F
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----
E
G
E
E
T
I
T
A
-------------
F
V
----------
E
-----------------------
P
---------
F
V
I
L
L
I
L
I
A
N
A
I
-------------
V
G
V
W
Q
E
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N
A
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A
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A
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K
E
Y
E
P
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-
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T
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Q
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V
S
V
I
K
H
T
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----------
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V
PDPRAVNQDKKNM
L
F
S
G
T
N
I
A
A
G
K
A
L
G
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V
A
T
T
G
V
S
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A
A
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T
P
L
Q
Q
K
L
D
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F
G
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Q
L
S
K
V
I
S
L
I
----
C
V
------
A
V
W
L
I
-------
N
I
G
HFNDP
V
-
H
G
G
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W
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G
A
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Y
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A
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A
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P
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A
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T
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T
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M
S
V
C
K
M
F
I
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D
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G
------------------
D
---
F
C
--------------
S
---
L
N
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S
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G
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K
P
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Q
-----------------
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---
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---
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----------------
L
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--------------------
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T
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C
A
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-----
L
D
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V
Y
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A
L
T
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L
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M
NVFNTEVRNLSKVERAN
A
C
N
S
V
------
I
-----
R
Q
L
M
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--
K
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L
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S
M
S
V
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N
K
M
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V
------
K
G
-
A
----
P
----
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------
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--
V
I
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R
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-------
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---------
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----
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D
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--------
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R
C
L
A
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------------------------
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-----
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------------------------
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DTPPKREEMVLDDSSR
F
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L
T
F
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V
V
G
M
L
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P
P
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V
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I
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G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
------------------------------------------
F
-----------------------------------------------------
G
ENEEVADRA--------------------------------------------
Y
T
G
R
E
F
D
D
LP
L
A
E
Q
R
E
A
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R
R
ACCFARVE
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V
L
A
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F
S
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I
V
A
A
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G
R
A
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N
M
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Q
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R
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-----
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S
S
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V
G
E
-
V
V
C
I
------
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L
T
-------
A
-
A
L
GLPEALI
P
V
Q
L
L
W
V
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L
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T
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G
L
P
A
T
A
L
G
F
N
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PD
L
--
D
I
M
D
R
P
P
RSPKEPLIS
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
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A
A
A
W
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MYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
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I
W
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D
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L
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L
M
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L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
YLEG--------------
44
HHSearch
63.70
21%
32
- C- -
3IXZ
-
ATP4A_PIG
A:
[140-798]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------
L
-----------------------
A
---------
L
A
L
I
A
V
V
V
V
T
G
C
-------------
F
G
Y
Y
Q
E
F
K
S
T
N
I
I
A
S
F
K
N
L
V
P
Q
Q
A
-
T
V
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D
G
D
K
F
Q
I
N
A
D
Q
L
V
V
--
G
D
L
V
E
M
K
G
G
D
R
V
P
A
D
I
R
I
L
--
Q
A
Q
G-
R
---
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
C
T
H
ESPLETR
N
I
-------------
A
F
F
S
T
M
C
L
E
G
T
A
Q
G
L
V
V
N
T
G
D
R
T
I
I
G
R
I
A
S
L
A
S
G
V
E
N
E
K
T
P
I
A
I
E
I
E
H
F
V
D
I
I
A
G
L
A
I
L
F
----
G
A
------
T
F
F
I
V
-------
A
M
C
-----
I
--
G
Y
T
F
----
L
R
A
M
V
F
F
M
A
I
V
V
A
Y
V
P
E
G
L
--
L
A
T
V
T
V
C
L
S
L
T
A
K
R
L
A
S
K
N
C
V
V
K
N
L
E
A
V
E
T
L
G
S
T
S
V
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
S
H
L
W
F
D
N
H
I
H
S
A
DTTEDQSGQTFDQS---
S
E
T
W
R
A
--------------
L
C
R
V
L
T
L
C
N
----------------------
R
-----------------
A
---
A
F
K
S
G
QDAVPVPK
R
I
------
V
I
G
D
--------------------
A
S
E
T
A
L
L
K
F
S
E
-----
L
T
L
--------------------------------------------
G
N
A
------
M
G
Y
R
E
R
F
P
K
V
C
EI
P
F
N
S
T
N
K
F
Q
------------------------
L
------
S
I
H
T
----
L
EDPR
D
------
P
R
H
V
----
L
V
M
K
G
A
P
E
R
V
L
E
-
R
C
S
-------
S
I
L
I
KGQE
L
P
L
D
E
Q
W
R
E
A
F
Q
T
A
Y
L
S
L
G
G
L
G
E
R
--------
V
L
G
F
C
Q
L
Y
L
S
EKDYPPGYAFDVEAMNFPTS
G
-----
L
------------------------
S
-------------------------
F
A
G
L
V
S
M
I
D
P
P
R
A
T
V
P
D
A
V
L
K
C
R
T
A
G
I
R
-
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
A
S
V
G
I
------------------------------------------
I
SEGS
E
T
V
E
D
I
A
ARLRVPVDQVNRKDAR
A
C
V
I
N
G
M
Q
L
K
D
MD
P
S
E
L
V
E
A
L
R
THPE
M
-----------------------------------------------------
V
F
A
R
T
S
----------------------
P
Q
Q
K
L
V
I
V
E
S
C
Q
R
L
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
A
A
K
N
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
Q
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
-----
L
T
K
N
I
P
E
-
L
T
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.44
24%
-75
- C3 -
1MHS
-
PMA1_NEUCR
A:
[124-713]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
--
F
V
M
E
G
----
A
A
----
V
L
A
A
G
L
E
D
-------------
W
V
----------
D
-----------------------
F
---------
G
V
I
C
G
L
L
L
L
N
A
V
-------------
V
G
F
V
Q
E
F
Q
A
G
S
I
V
D
E
L
K
K
T
L
A
L
K
A
-
V
V
L
R
D
G
T
L
K
E
I
E
A
P
E
V
V
P
--
G
D
I
L
Q
V
E
E
G
T
I
I
P
A
D
G
R
I
V
TD
D
A
F
--
L
---
Q
V
D
Q
S
A
L
T
G
E
S
L
A
V
D
K
H
K
G
----------
D
Q
-------------
V
F
A
S
S
A
V
K
R
G
E
A
F
V
V
I
T
A
T
G
D
N
T
F
V
G
R
A
A
A
L
V
N
A
A
S
G
G
S
G
H
F
T
E
V
L
N
G
I
G
-----
T
I
L
L
I
L
V
I
F
T
L
------
L
I
V
W
V
-------
S
S
F
-----
Y
-
R
S
N
P
I
----
V
Q
I
L
E
F
T
L
A
I
T
I
I
G
V
P
V
G
L
P
A
V
V
T
T
T
M
A
V
G
A
A
Y
--
L
A
K
K
K
A
I
V
Q
K
L
S
A
I
E
S
L
A
G
V
E
I
L
C
S
D
K
T
G
T
L
T
K
N
K
L
S
L
H
D
--
P
Y
T
V
A
G
V
------------------
D
---
P
E
--------------
D
---
L
M
L
T
A
----------------------
C
LAASRKKKGIDA
I
D
K
A
F
L
---
K
---
S
----------------
L
K
Y
Y
--------------------
P
R
A
K
S
V
L
S
K
--------------------------------------------------------
Y
------
K
-----
V
L
Q
F
H
--
P
F
D
P
V
S
K
K
V
------------------------
V
A
V
V
E
S
P
Q
G
-
E
R
I
T
C
V
----
K
------
G
--
A
----
P
L
F
V
--
L
K
T
V
E
E
-
D
-
H
-------
P
---------
I
----
P
E
E
V
D
Q
A
Y
K
N
K
V
A
E
F
A
T
R
G
F
R
S
L
G
V
A
R
K
R
G
E
------------------------
G
-----
S
W
-----------------------
E
-------------------------
I
L
G
I
M
P
C
M
D
P
P
R
H
D
T
Y
K
T
V
C
E
A
K
T
L
G
L
S
-
I
K
M
L
T
G
D
A
V
G
I
A
R
E
T
S
R
Q
L
G
L
GTNIYNAERLGLGGGGDMPGSEV
Y
D
F
V
E
A-------------
A
-----------------------------------------------------
D
-----------------------------------------------------
G
F
A
E
V
F
----------------------
P
Q
H
K
Y
N
V
V
E
I
L
Q
Q
R
G
Y
L
V
A
M
T
G
D
G
V
N
D
A
P
S
L
K
K
A
D
T
G
I
A
V
E
G
S
-
S
D
A
A
R
S
A
A
D
I
V
F
L
A
P
G
L
G
A
I
I
D
A
L
K
T
S
R
Q
I
F
H
R
M
Y
A
Y
V
V
Y
R
----------
I
A
-
L
S
I
H
------
L
E
I
-------
F
-
L
G
-----------
L
W
I
A
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
61.80
23%
-65
- C3 -
1MHS
-
PMA1_NEUCR
A:
[128-702]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
G
A
A
----
V
L
A
A
G
L
E
D
-------------
W
V
----------
D
-----------------------
F
---------
G
V
I
C
G
L
L
L
L
N
A
V
-------------
V
G
F
V
Q
E
F
Q
A
G
S
I
V
D
E
L
K
K
T
L
A
L
K
A
-
V
V
L
R
D
G
T
L
K
E
I
E
A
P
E
V
V
P
--
G
D
I
L
Q
V
E
E
G
T
I
I
P
A
D
G
R
I
V
--
T
D
D
A
F
L
---
Q
V
D
Q
S
A
L
T
G
E
S
L
A
V
D
K
H
K
G
----------
D
Q
-------------
V
F
A
S
S
A
V
K
R
G
E
A
F
V
V
I
T
A
T
G
D
N
T
F
V
G
R
A
A
A
L
V
N
A
A
S
G
G
S
G
H
F
T
E
V
L
N
G
I
G
T
I
L
L
I
L
V
I
F
T
----
L
L
------
I
V
W
V
S
-------
S
F
Y
-----
R
--
S
N
P
I
----
V
Q
I
L
E
F
T
L
A
I
T
I
I
G
V
P
V
G
L
--
P
A
V
V
T
T
T
M
A
V
G
A
A
Y
L
A
K
K
K
A
I
V
Q
K
L
S
A
I
E
S
L
A
G
V
E
I
L
C
S
D
K
T
G
T
L
T
K
N
K
L
S
L
H
D
P
Y
T
V
A
-
G
V
D
------------------
P
---
E
D
--------------
L
---
M
L
T
A
C
----------------------
L
-----------------
A
ASR
K
---
K
----------------
K
G
I
D
--------------------
A
I
D
K
A
F
L
K
S
L
K
-----
Y
Y
P
--------------------------------------------
R
A
K
SVLS
K
Y
K
-----
V
L
Q
F
H
--
P
F
D
P
V
-
S
K
K
------------------------
V
------
V
A
-
V
----
V
----
E
S
PQ---
G
--
E
R
I
--
T
C
V
K
G
A
P
L
F
V
L
K
-
T
V
E
EDHPIP
E
E
---------
V
----
D
Q
A
Y
K
N
K
V
A
E
F
A
T
R
G
F
R
--------
S
L
G
V
A
R
------------------------
K
RGEG
S
W
------------------------
E
-------------------------
I
L
G
I
M
P
C
M
D
P
P
R
H
D
T
Y
K
T
V
C
E
A
K
T
L
G
L
S
-
I
K
M
L
T
G
D
A
V
G
I
A
R
E
T
S
R
Q
L
G
L
------------------------------------------
G
TNIYNAERLGLGGGGDMPGSEV
Y
D
F
V
E
AA------------------------
D
-----------------------------------------------------
G
F
A
E
V
F
----------------------
P
Q
H
K
Y
N
V
V
E
I
L
Q
Q
R
G
Y
L
V
A
M
T
G
D
G
V
N
D
A
P
S
L
K
K
A
D
T
G
I
A
V
E
-
G
S
S
D
A
A
R
S
A
A
D
I
V
F
L
A
P
G
L
G
A
I
I
D
A
L
K
T
S
R
Q
I
F
H
R
M
Y
A
Y
V
V
Y
R
-----
I
A
L
S
I
H
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
58.24
37%
-73
- C3 -
3A1C
1
?
B:
[14-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
--
N
G
D
------------------
E
---
R
E
--------------
L
---
L
R
L
A
A
----------------------
I
-----------------
A
---
E
---
R
----------------
R
S
E
H
--------------------
P
I
A
E
A
I
V
K
K
A
L
-----
E
H
G
--------------------------------------------
I
E
L
------
G
-------
E
P
E
--
K
V
E
V
I
A
G
E
G
------------------------
V
------
V
A
-----------
D
------
G
--
I
------
L
V
G
N
K
R
L
M
E
D
F
G
-
V
-------
A
---------
V
----
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
--------
A
V
I
V
A
R
------------------------
N
-----
G
------------------------
R
-------------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
-
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
----------------------
P
H
Q
K
S
E
E
V
K
K
L
-
Q
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.55
37%
-72
- C3 -
3A1E
2
COPA_ARCFU
A:
[14-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
--
N
G
D
------------------
E
---
R
E
--------------
L
---
L
R
L
A
A
----------------------
I
-----------------
A
---
E
---
R
----------------
R
S
E
Q
--------------------
P
I
A
E
A
I
V
K
K
A
L
-----
E
H
G
--------------------------------------------
I
E
L
------
G
-------
E
P
E
--
K
V
E
V
I
A
G
E
G
------------------------
V
------
V
A
-----------
D
------
G
--
I
------
L
V
G
N
K
R
L
M
E
D
F
G
-
V
-------
A
---------
V
----
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
--------
A
V
I
V
A
R
------------------------
N
-----
G
------------------------
R
-------------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
-
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
----------------------
P
H
Q
K
S
E
E
V
K
K
L
-
Q
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.29
37%
-71
- C3 -
3A1D
2
?
A:
[14-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
--
N
G
D
------------------
E
---
R
E
--------------
L
---
L
R
L
A
A
----------------------
I
-----------------
A
---
E
---
R
----------------
R
S
E
H
--------------------
P
I
A
E
A
I
V
K
K
A
L
-----
E
H
G
--------------------------------------------
I
E
L
------
G
-------
E
P
E
--
K
V
E
V
I
A
G
E
G
------------------------
V
------
V
A
-----------
D
------
G
--
I
------
L
V
G
N
K
R
L
M
E
D
F
G
-
V
-------
A
---------
V
----
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
--------
A
V
I
V
A
R
------------------------
N
-----
G
------------------------
R
-------------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
-
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
----------------------
P
H
Q
K
S
E
E
V
K
K
L
-
Q
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
57.18
38%
-72
- C3 -
3A1C
2
?
A:
[14-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
--
G
D
------------------
E
---
R
E
--------------
L
---
L
R
L
A
A
----------------------
I
-----------------
A
---
E
---
R
----------------
R
S
E
H
--------------------
P
I
A
E
A
I
V
K
K
A
L
-----
E
H
G
--------------------------------------------
I
E
L
-------------
G
E
P
E
--
K
V
E
V
I
A
G
E
G
------------------------
V
------
V
A
---------------------
D
----
G
I
L
V
G
N
K
R
L
M
E
D
-
F
G
V
-------
A
---------
V
----
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
--------
A
V
I
V
A
R
------------------------
N
-----
G
------------------------
R
-------------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
-
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
----------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
57.13
37%
-72
- C3 -
3A1D
2
?
B:
[14-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
--
N
G
D
------------------
E
---
R
E
--------------
L
---
L
R
L
A
A
----------------------
I
-----------------
A
---
E
---
R
----------------
R
S
E
H
--------------------
P
I
A
E
A
I
V
K
K
A
L
-----
E
H
G
--------------------------------------------
I
E
L
------
G
-------
E
P
E
--
K
V
E
V
I
A
G
E
G
------------------------
V
------
V
A
-----------
D
------
G
--
I
------
L
V
G
N
K
R
L
M
E
D
F
G
-
V
-------
A
---------
V
----
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
--------
A
V
I
V
A
R
------------------------
N
-----
G
------------------------
R
-------------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
-
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
----------------------
P
H
Q
K
S
E
E
V
K
K
L
-
Q
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
56.82
37%
-72
- C3 -
3A1E
1
B:
[14-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
--
N
G
D
------------------
E
---
R
E
--------------
L
---
L
R
L
A
A
----------------------
I
-----------------
A
---
E
---
R
----------------
R
S
E
Q
--------------------
P
I
A
E
A
I
V
K
K
A
L
-----
E
H
G
--------------------------------------------
I
E
L
------
G
-------
E
P
E
--
K
V
E
V
I
A
G
E
G
------------------------
V
------
V
A
-----------
D
------
G
--
I
------
L
V
G
N
K
R
L
M
E
D
F
G
-
V
-------
A
---------
V
----
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
--------
A
V
I
V
A
R
------------------------
N
-----
G
------------------------
R
-------------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
-
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
----------------------
P
H
Q
K
S
E
E
V
K
K
L
-
Q
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
56.47
37%
-71
- C3 -
3A1C
2
?
A:
[14-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
--
N
G
D
------------------
E
---
R
E
--------------
L
---
L
R
L
A
A
----------------------
I
-----------------
A
---
E
---
R
----------------
R
S
E
H
--------------------
P
I
A
E
A
I
V
K
K
A
L
-----
E
H
G
--------------------------------------------
I
E
L
------
G
-------
E
P
E
--
K
V
E
V
I
A
G
E
G
------------------------
V
------
V
A
-----------
D
------
G
--
I
------
L
V
G
N
K
R
L
M
E
D
F
G
-
V
-------
A
---------
V
----
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
--------
A
V
I
V
A
R
------------------------
N
-----
G
------------------------
R
-------------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
-
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
------------------------------------------
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
----------------------
P
H
Q
K
S
E
E
V
K
K
L
-
Q
A
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
49.25
33%
-55
- C3 -
2YJ4
1
?
B:
[13-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
T
Q
F
I
G
D
S
L
-----------------------------------------
S
---
L
A
Y
A
A
----------------------
S
-----------------
V
---
E
---
A
----------------
L
S
S
H
--------------------
P
I
A
K
A
I
V
K
Y
A
K
-----
E
Q
G
--------------------------------------------
V
--------
K
-----
I
L
E
V
K
--
D
F
K
E
I
S
G
I
G
------------------------
V
------
R
G
-
K
----
I
------------------------
S
D
K
I
I
E
----------------------------------
V
K
K
A
E
N
N
N
D
I
--------
A
V
Y
I
N
G
------------------------
E
-----
P
---------------------------------------------------
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
-
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
------------------------------------------
Q
-----------------------------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
----------------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
N
-
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
-
N
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
48.07
33%
-61
- C3 -
2YJ5
1
?
B:
[13-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
T
Q
F
I
G
D
S
L
-----------------------------------------
S
---
L
A
Y
A
A
----------------------
S
-----------------
V
---
E
---
A
----------------
L
S
S
H
--------------------
P
I
A
K
A
I
V
K
Y
A
K
-----
E
Q
G
--------------------------------------------
V
--------
K
-----
I
L
E
V
K
--
D
F
K
E
I
S
G
I
G
------------------------
V
------
R
G
-
K
----
I
------------------------
S
D
K
I
I
E
----------------------------------
V
K
K
A
E
N
N
N
D
I
--------
A
V
Y
I
N
G
------------------------
E
-----
P
---------------------------------------------------
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
-
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
------------------------------------------
Q
-----------------------------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
----------------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
N
-
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
-
N
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
47.35
33%
-59
- C3 -
2YJ6
1
?
A:
[13-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
T
Q
F
I
G
D
S
L
-----------------------------------------
S
---
L
A
Y
A
A
----------------------
S
-----------------
V
---
E
---
A
----------------
L
S
S
H
--------------------
P
I
A
K
A
I
V
K
Y
A
K
-----
E
Q
G
--------------------------------------------
V
--------
K
-----
I
L
E
V
K
--
D
F
K
E
I
S
G
I
G
------------------------
V
------
R
G
-
K
----
I
------------------------
S
D
K
I
I
E
----------------------------------
V
K
K
A
E
N
N
N
D
I
--------
A
V
Y
I
N
G
------------------------
E
-----
P
---------------------------------------------------
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
-
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
------------------------------------------
Q
-----------------------------------------------------
E
-----------------------------------------------------
Y
Y
S
N
L
S
----------------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
N
----
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
-
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------