@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1153: (2016-03-22 )
MKSKRFEELAKRPVNQDGFVKEWIEEGLIAMESPNDPKPSIKIENGKVVEMDSKKLADFDLIDHFIAKYGVDLSRAEEVMQMDSVKLANMLCDPNVPREKIVLLTTAMTPAKIVEVVSQMNVVEMMMSMQKMRSRRTPTTQAHVTNLRDNPVQIAADAAEAAIRGFDEQETTVAVVRYAPFNALSLLVGSQTGRGGVLTQCSLEEATELELGMRGLTCYAETISVYGTEPVFTDGDDTPWSKGILASAYASRGLKMRFTSGTGSEVQMGYAEGKSMLYLESRCIFITKAAGVQGLQNGSISCIGIPGAVPSGIRAVLAENLIAVMLDLEVASGNDQTFSHSDIRRTARLLMQFLPGTDYISSGYSATPNYDNMFAGSNFDADDFDDYNILQRDLKVDGGLTPVTEEEVVAVRNKAARVIQAVFDKLGLPEVTDAEVEAATYARGSKDMPERNMVEDIKAAAEMMDRGVTGLDVVKALSAGGFDDVAESVLNMLKQRVSGDFLHTSAIIDKDWNVISSVNDLNDYAGPGTGYRLEGERWEKLKDIAVAVDANELD
Atome Classification :
(20 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MK
S
K
R
F
E
E
L
A
KRPVNQD
G
F
V
K
E
W
I
EEG
L
I
AMESPNDPKP
S
I
K
IEN
G
K
V
V
EMDSKKLA
D
F
D
L
I
D
H
F
I
A
KYGV
D
L
S
R
A
E
E
V
M
Q
M
D
S
V
K
L
A
N
MLCDPNVPR
E
K
I
V
L
L
TTAM
T
P
A
K
I
V
E
V
V
S
Q
M
N
V
V
E
M
M
M
S
M
Q
K
M
R
SRRTPTTQ
A
H
V
TNLRDN
P
V
Q
I
A
A
D
A
A
E
A
A
I
RGFDEQE
T
T
V
A
V
V
RYA
P
F
N
A
L
S
L
L
VGSQTGRG
G
V
L
T
Q
CSLE
E
A
T
E
L
E
L
GMRG
L
T
C
Y
A
E
T
I
S
VYGTEPVFTDGDDTPWSK
G
I
L
A
S
A
Y
A
SRG
L
K
M
R
FTSGTGS
E
V
Q
M
G
YAEG
K
S
M
L
Y
L
ES
R
C
I
F
I
T
KAAGVQGLQNG
S
I
S
C
I
GIPGAV
P
S
G
I
R
A
V
L
A
E
N
L
I
A
V
M
L
D
L
E
VASGNDQTF
S
H
S
D
I
R
R
T
A
R
L
L
M
Q
FLPGTDYISSGYSATPNYDNMFAGSNFDADDFD
D
Y
N
I
L
Q
R
D
L
KVDGGLTPV
T
E
E
E
V
V
A
V
R
N
K
A
A
R
V
I
Q
A
V
F
D
KLGLPEVTDAE
V
E
A
A
TYARGSKDMP
E
R
N
M
V
E
D
I
K
A
A
A
E
M
M
D
RGV
T
G
L
D
V
V
K
A
L
SAG
G
F
D
D
V
A
E
S
V
L
N
M
L
K
Q
RVSGDFLH
T
S
A
IIDKDW
N
V
I
S
SVND
L
N
DYAGPGTGYRLE
G
E
R
W
E
K
L
K
D
I
A
V
A
VDANELD
8
PsiBlast_PDB
99.21
79%
-61
- C3 -
3AUJ
4
?
A:
[1-552]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
E
--
21
PsiBlast_CBE
99.20
79%
-61
- C3 -
3AUJ
4
?
L:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
23
PsiBlast_CBE
98.63
79%
-59
- C3 -
1UC4
5
?
L:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
24
PsiBlast_CBE
98.61
79%
-61
- C3 -
1IWB
4
?
L:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
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S
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I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
27
PsiBlast_CBE
98.58
79%
-62
- C3 -
1EEX
4
?
L:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
6
PsiBlast_PDB
98.52
79%
-61
- C3 -
1UC4
5
?
A:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
34
HHSearch
98.41
80%
-60
- C3 -
1EEX
4
?
A:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
22
PsiBlast_CBE
98.27
79%
-58
- C3 -
1UC5
5
?
L:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
2
PsiBlast_PDB
98.23
79%
-61
- C3 -
1EGM
3
?
A:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
5
PsiBlast_PDB
98.17
79%
-61
- C3 -
1IWB
4
?
A:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
3
PsiBlast_PDB
98.16
79%
-60
- C3 -
1EEX
4
?
A:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
51
Fugue
98.13
79%
-60
- C3 -
1EEX
4
?
A:
[1-551]
M-
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
7
PsiBlast_PDB
98.13
79%
-59
- C3 -
1UC5
5
?
A:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
4
PsiBlast_PDB
98.10
79%
-61
- C3 -
1EGV
4
?
A:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
28
PsiBlast_CBE
98.08
79%
-59
- C3 -
1DIO
3
?
L:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
26
PsiBlast_CBE
98.05
79%
-60
- C3 -
1EGM
3
?
L:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
25
PsiBlast_CBE
97.94
79%
-60
- C3 -
1EGV
4
?
L:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
50
Fugue
97.93
79%
-58
- C3 -
1DIO
3
?
A:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
1
PsiBlast_PDB
97.93
79%
-58
- C3 -
1DIO
3
?
A:
[1-551]
-
M
R
S
K
R
F
E
A
L
A
K
R
P
V
N
Q
D
G
F
V
K
E
W
I
E
E
G
F
I
A
M
E
S
P
N
D
P
K
P
S
I
K
I
V
N
G
A
V
T
E
L
D
G
K
P
V
S
D
F
D
L
I
D
H
F
I
A
R
Y
G
I
N
L
N
R
A
E
E
V
M
A
M
D
S
V
K
L
A
N
M
L
C
D
P
N
V
K
R
S
E
I
V
P
L
T
T
A
M
T
P
A
K
I
V
E
V
V
S
H
M
N
V
V
E
M
M
M
A
M
Q
K
M
R
A
R
R
T
P
S
Q
Q
A
H
V
T
N
V
K
D
N
P
V
Q
I
A
A
D
A
A
E
G
A
W
R
G
F
D
E
Q
E
T
T
V
A
V
A
R
Y
A
P
F
N
A
I
A
L
L
V
G
S
Q
V
G
R
P
G
V
L
T
Q
C
S
L
E
E
A
T
E
L
K
L
G
M
L
G
H
T
C
Y
A
E
T
I
S
V
Y
G
T
E
P
V
F
T
D
G
D
D
T
P
W
S
K
G
F
L
A
S
S
Y
A
S
R
G
L
K
M
R
F
T
S
G
S
G
S
E
V
Q
M
G
Y
A
E
G
K
S
M
L
Y
L
E
A
R
C
I
Y
I
T
K
A
A
G
V
Q
G
L
Q
N
G
S
V
S
C
I
G
V
P
S
A
V
P
S
G
I
R
A
V
L
A
E
N
L
I
C
S
S
L
D
L
E
C
A
S
S
N
D
Q
T
F
T
H
S
D
M
R
R
T
A
R
L
L
M
Q
F
L
P
G
T
D
F
I
S
S
G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
E
D
A
E
D
F
D
D
Y
N
V
I
Q
R
D
L
K
V
D
G
G
L
R
P
V
R
E
E
D
V
I
A
I
R
N
K
A
A
R
A
L
Q
A
V
F
A
G
M
G
L
P
P
I
T
D
E
E
V
E
A
A
T
Y
A
H
G
S
K
D
M
P
E
R
N
I
V
E
D
I
K
F
A
Q
E
I
I
N
K
N
R
N
G
L
E
V
V
K
A
L
A
Q
G
G
F
T
D
V
A
Q
D
M
L
N
I
Q
K
A
K
L
T
G
D
Y
L
H
T
S
A
I
I
V
G
D
G
Q
V
L
S
A
V
N
D
V
N
D
Y
A
G
P
A
T
G
Y
R
L
Q
G
E
R
W
E
E
I
K
N
I
P
G
A
L
D
P
N
---
9
PsiBlast_PDB
95.18
71%
-56
- C3 -
1IWP
3
?
A:
[3-555]
--
R
S
K
R
F
A
V
L
A
Q
R
P
V
N
Q
D
G
L
I
G
E
W
P
E
E
G
L
I
A
M
D
S
P
F
D
P
V
S
S
V
K
V
D
N
G
L
I
V
E
L
D
G
K
R
R
D
Q
F
D
M
I
D
R
F
I
A
D
Y
A
I
N
V
E
R
T
E
Q
A
M
R
L
E
A
V
E
I
A
R
M
L
V
D
I
H
V
S
R
E
E
I
I
A
I
T
T
A
I
T
P
A
K
A
V
E
V
M
A
Q
M
N
V
V
E
M
M
M
A
L
Q
K
M
R
A
R
R
T
P
S
N
Q
C
H
V
T
N
L
K
D
N
P
V
Q
I
A
A
D
A
A
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A
G
I
R
G
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S
E
Q
E
T
T
V
G
I
A
R
Y
A
P
F
N
A
L
A
L
L
V
G
S
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C
G
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P
G
V
L
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C
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V
E
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A
T
E
L
E
L
G
M
R
G
L
T
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Y
A
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V
Y
G
T
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A
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F
T
D
G
D
D
T
P
W
S
K
A
F
L
A
S
A
Y
A
S
R
G
L
K
M
R
Y
T
S
G
T
G
S
E
A
L
M
G
Y
S
E
S
K
S
M
L
Y
L
E
S
R
C
I
F
I
T
K
G
A
G
V
Q
G
L
Q
N
G
A
V
S
C
I
G
M
T
G
A
V
P
S
G
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R
A
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L
A
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N
L
I
A
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M
L
D
L
E
V
A
S
A
N
D
Q
T
F
S
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S
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I
R
R
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A
R
T
L
M
Q
M
L
P
G
T
D
F
I
F
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G
Y
S
A
V
P
N
Y
D
N
M
F
A
G
S
N
F
D
A
E
D
F
D
D
Y
N
I
L
Q
R
D
L
M
V
D
G
G
L
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P
V
T
E
A
E
T
I
A
I
R
Q
K
A
A
R
A
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Q
A
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F
R
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L
G
L
P
P
I
A
D
E
E
V
E
A
A
T
Y
A
H
G
S
N
E
M
P
P
R
N
V
V
E
D
L
S
A
V
E
E
M
M
K
R
N
I
T
G
L
D
I
V
G
A
L
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R
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G
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A
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N
I
L
N
M
L
R
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R
V
T
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D
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L
Q
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A
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D
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Q
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V
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A
V
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D
I
N
D
Y
Q
G
P
G
T
G
Y
R
I
S
A
E
R
W
A
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K
N
I
P
G
V
V
Q
P
D
T
I
E