@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1156: (2016-03-22 )
MKYIAGIDIGNSTTEVALAMANSSKEAAFVASAITDTTGIKGTKQNLHGIFKALRLALEKVNATTEDLAEIRINEATPVIGDVAMETITETIITESTMIGHNPKTPGGLGMGSGVTVLLDDVTSKSKDADYIVIIPKTVDFEDAAKQINTYVENGYQITAAILQADDGVLVHNRLNHKIPIVDEVGFIDKVPVDMLAAVEVAAPGKVIETISNPYGIATVFHLNSDETKNIIPVARALIGNRSAVVIKTPEGDVKARTIPAGHIELQSGSRTQRVNVAEGSEKIMQAIMSLPKLDNASGEPGTNIGGMLEKVRQTMAGLTDKLPADIFIQDLLAVDTFVPVDVQGGLAGEFSMEQAVGIASMVKSDHLQMAAIASEIEQELQVSVKIGGAEAEAAILGALTTPGTNTPLAILDLGAGSTDASIINGKGEIIATHLAGAGDMVTMIIQSEIGLEDRYLAEDIKKYPLAKVESIFHIRHEDGTVQFFDTPLSPTVFAKVVIVKPDGFVPIPGDVSIEKIKLIRRSAKERVFVTNTIRALKYVSPTGNIRDIPFVVIVGGSALDFEIPQLITDALSHYSLVAGRGNIRGKEGPRNAVATGLILAGGAKA
Atome Classification :
(20 SA)
.........10........20........30........40-........50........60........70........80........90....--....100.......110.......120..--...---..---130........140-.......-----150.......160.......170.......180.......190.......200.......210.---......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320--.......330..--------.....340.......350.......360.......370.......380.......390.......--400---.-------......410.......420...--..--..--430-.-----.--.---......440.......450--------..------------------.-----------.-------------------....460.......470..-.-..--..480.........490.......500.......510.......520--..--......530.......540.......550.......560.......570.......580------..-----..-------------....---.590.......600....---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
Y
I
A
G
I
DIGNST
T
E
V
A
L
A
MANSSKE
A
A
F
V
A
SAITDTTGIK-G
T
K
Q
N
L
H
G
I
F
K
A
L
R
L
A
L
E
K
VNA
T
T
E
D
L
A
E
IRINEATP
V
I
G
D
V
A
M
E
T
I
T
E
T
I
ITE--STMIGHNPKTPGGLGMGS
G
V
T
V
L
L
DDVTS--KSK---DA---
D
-
Y
I
V
I
I
PKTV
D
F
E
-
D
A
A
K
Q
I
N
-----
T
Y
V
EN
G
Y
Q
I
T
A
A
I
L
QADD
G
V
L
V
HNRLNHKIPIVDEVGFIDKV
P
V
D
M
L
A
A
VEVAAP
G
K
V
I
E
TISN---PY
G
I
A
T
V
F
H
LNSDETK
N
I
I
P
V
A
R
A
LIGNR
S
A
V
V
I
KTPEGD
V
K
A
R
TIP
A
G
H
I
E
LQSGSR
T
Q
R
V
NVAE
G
S
E
K
I
M
Q
A
I
M
SLPKLDNASGEPGT
N
I
G
G
M
L
E
K
V
R
Q
T
M
A
G
L
TDK--L
P
A
D
I
F
I
Q
D
L
L
A--------VDTFV
P
V
DVQGGLAGE
F
S
M
E
Q
A
V
G
I
A
S
M
V
K
SD
H
L
Q
M
A
A
I
A
S
E
I
E
Q
E
L
Q
V
S
V
K
IGGAEAE
A
A
I
L
G
A--LTT---P-------GTNT
P
L
A
I
L
D
LGAGSTD
A
S
I
IN--GK--G
E
--
I
---
I
-----
A
--
T
---HLAGAGD
M
V
T
M
I
I
QSEIG---------LE------------------
D
-----------
R
-------------------
Y
L
A
E
D
I
K
KY
P
L
A
K
V
E
S
I
F
H
-
I
-RH--EDG--
T
V
Q
F
FDTPLSP
T
V
F
A
K
V
V
I
VKPDGFVPIPGDV
S
I
E
K
I
K
L
I
R
---
R
S--AK
E
R
V
F
V
T
N
T
I
R
A
L
K
YVSPTGNIRDI
P
F
V
V
I
VGGSALDFE
I
P
Q
L
I
T
D
A
L
S
H
Y
S
L
VAG--------RG-----NI-------------RGKE---GPR
N
A
V
AT
G
L
I
LAGGAKA---------------
13
HHSearch
99.65
70%
-108
- C6 -
2D0O
3
DDRFA_KLEOK
A:
[1-605]
M
R
Y
I
A
G
I
D
I
G
N
S
S
T
E
V
A
L
A
T
L
D
E
A
G
A
L
T
I
T
H
S
A
L
A
E
T
T
G
I
K
-
G
T
L
R
N
V
F
G
I
Q
E
A
L
A
L
V
A
R
G
A
G
I
A
V
S
D
I
S
L
I
R
I
N
E
A
T
P
V
I
G
D
V
A
M
E
T
I
T
E
T
I
I
T
E
--
S
T
M
I
G
H
N
P
K
T
P
G
G
A
G
L
G
T
G
I
T
I
T
P
Q
E
L
L
T
--
R
P
A
---
D
A
---
P
-
Y
I
L
V
V
S
S
A
F
D
F
A
-
D
I
A
S
V
I
N
-----
A
S
L
R
A
G
Y
Q
I
T
G
V
I
L
Q
R
D
D
G
V
L
V
S
N
R
L
E
K
P
L
P
I
V
D
E
V
L
Y
I
D
R
I
P
L
G
M
L
A
A
I
E
V
A
V
P
G
K
V
I
E
T
L
S
N
---
P
Y
G
I
A
T
V
F
N
L
S
P
E
E
T
K
N
I
V
P
M
A
R
A
L
I
G
N
R
S
A
V
V
V
K
T
P
S
G
D
V
K
A
R
A
I
P
A
G
N
L
E
L
L
A
Q
G
R
S
V
R
V
D
V
A
A
G
A
E
A
I
M
K
A
V
D
G
C
G
R
L
D
N
V
T
G
E
S
G
T
N
I
G
G
M
L
E
H
V
R
Q
T
M
A
E
L
T
N
K
--
P
S
S
E
I
F
I
Q
D
L
L
A
--------
V
D
T
S
V
P
V
S
V
T
G
G
L
A
G
E
F
S
L
E
Q
A
V
G
I
A
S
M
V
K
S
D
R
L
Q
M
A
M
I
A
R
E
I
E
Q
K
L
N
I
D
V
Q
I
G
G
A
E
A
E
A
A
I
L
G
A
--
L
T
T
---
P
-------
G
T
T
R
P
L
A
I
L
D
L
G
A
G
S
T
D
A
S
I
I
N
--
P
K
--
G
D
--
I
---
I
-----
A
--
T
---
H
L
A
G
A
G
D
M
V
T
M
I
I
A
R
E
L
G
---------
L
E
------------------
D
-----------
R
-------------------
Y
L
A
E
E
I
K
K
Y
P
L
A
K
V
E
S
L
F
H
-
L
-
R
H
--
E
D
G
--
S
V
Q
F
F
S
T
P
L
P
P
A
V
F
A
R
V
C
V
V
K
A
D
E
L
V
P
L
P
G
D
L
A
L
E
K
V
R
A
I
R
---
R
S
--
A
K
E
R
V
F
V
T
N
A
L
R
A
L
R
Q
V
S
P
T
G
N
I
R
D
I
P
F
V
V
L
V
G
G
S
S
L
D
F
E
V
P
Q
L
V
T
D
A
L
A
H
Y
R
L
V
A
G
--------
R
G
-----
N
I
-------------
R
G
S
E
---
G
P
R
N
A
V
A
T
G
L
I
L
S
W
H
K
E
----------------
1
PsiBlast_PDB
99.34
70%
-109
- C6 -
2D0O
3
DDRFA_KLEOK
A:
[1-601]
M
R
Y
I
A
G
I
D
I
G
N
S
S
T
E
V
A
L
A
T
L
D
E
A
G
A
L
T
I
T
H
S
A
L
A
E
T
T
G
I
K
-
G
T
L
R
N
V
F
G
I
Q
E
A
L
A
L
V
A
R
G
A
G
I
A
V
S
D
I
S
L
I
R
I
N
E
A
T
P
V
I
G
D
V
A
M
E
T
I
T
E
T
I
I
T
E
--
S
T
M
I
G
H
N
P
K
T
P
G
G
A
G
L
G
T
G
I
T
I
T
P
Q
E
L
L
T
--
R
P
A
---
D
A
---
P
-
Y
I
L
V
V
S
S
A
F
D
F
A
-
D
I
A
S
V
I
N
-----
A
S
L
R
A
G
Y
Q
I
T
G
V
I
L
Q
R
D
D
G
V
L
V
S
N
R
L
E
K
P
L
P
I
V
D
E
V
L
Y
I
D
R
I
P
L
G
M
L
A
A
I
E
V
A
V
P
G
K
V
I
E
T
L
S
N
---
P
Y
G
I
A
T
V
F
N
L
S
P
E
E
T
K
N
I
V
P
M
A
R
A
L
I
G
N
R
S
A
V
V
V
K
T
P
S
G
D
V
K
A
R
A
I
P
A
G
N
L
E
L
L
A
Q
G
R
S
V
R
V
D
V
A
A
G
A
E
A
I
M
K
A
V
D
G
C
G
R
L
D
N
V
T
G
E
S
G
T
N
I
G
G
M
L
E
H
V
R
Q
T
M
A
E
L
T
N
K
--
P
S
S
E
I
F
I
Q
D
L
L
A
--------
V
D
T
S
V
P
V
S
V
T
G
G
L
A
G
E
F
S
L
E
Q
A
V
G
I
A
S
M
V
K
S
D
R
L
Q
M
A
M
I
A
R
E
I
E
Q
K
L
N
I
D
V
Q
I
G
G
A
E
A
E
A
A
I
L
G
A
--
L
T
T
---
P
-------
G
T
T
R
P
L
A
I
L
D
L
G
A
G
S
T
D
A
S
I
I
N
--
P
K
--
G
D
--
I
---
I
-----
A
--
T
---
H
L
A
G
A
G
D
M
V
T
M
I
I
A
R
E
L
G
---------
L
E
------------------
D
-----------
R
-------------------
Y
L
A
E
E
I
K
K
Y
P
L
A
K
V
E
S
L
F
H
-
L
-
R
H
--
E
D
G
--
S
V
Q
F
F
S
T
P
L
P
P
A
V
F
A
R
V
C
V
V
K
A
D
E
L
V
P
L
P
G
D
L
A
L
E
K
V
R
A
I
R
---
R
S
--
A
K
E
R
V
F
V
T
N
A
L
R
A
L
R
Q
V
S
P
T
G
N
I
R
D
I
P
F
V
V
L
V
G
G
S
S
L
D
F
E
V
P
Q
L
V
T
D
A
L
A
H
Y
R
L
V
A
G
--------
R
G
-----
N
I
-------------
R
G
S
E
---
G
P
R
N
A
V
A
T
G
L
I
L
S
--------------------
10
PsiBlast_CBE
99.31
70%
-109
- C6 -
2D0O
3
DDRFA_KLEOK
C:
[1-601]
M
R
Y
I
A
G
I
D
I
G
N
S
S
T
E
V
A
L
A
T
L
D
E
A
G
A
L
T
I
T
H
S
A
L
A
E
T
T
G
I
K
-
G
T
L
R
N
V
F
G
I
Q
E
A
L
A
L
V
A
R
G
A
G
I
A
V
S
D
I
S
L
I
R
I
N
E
A
T
P
V
I
G
D
V
A
M
E
T
I
T
E
T
I
I
T
E
--
S
T
M
I
G
H
N
P
K
T
P
G
G
A
G
L
G
T
G
I
T
I
T
P
Q
E
L
L
T
--
R
P
A
---
D
A
---
P
-
Y
I
L
V
V
S
S
A
F
D
F
A
-
D
I
A
S
V
I
N
-----
A
S
L
R
A
G
Y
Q
I
T
G
V
I
L
Q
R
D
D
G
V
L
V
S
N
R
L
E
K
P
L
P
I
V
D
E
V
L
Y
I
D
R
I
P
L
G
M
L
A
A
I
E
V
A
V
P
G
K
V
I
E
T
L
S
N
---
P
Y
G
I
A
T
V
F
N
L
S
P
E
E
T
K
N
I
V
P
M
A
R
A
L
I
G
N
R
S
A
V
V
V
K
T
P
S
G
D
V
K
A
R
A
I
P
A
G
N
L
E
L
L
A
Q
G
R
S
V
R
V
D
V
A
A
G
A
E
A
I
M
K
A
V
D
G
C
G
R
L
D
N
V
T
G
E
S
G
T
N
I
G
G
M
L
E
H
V
R
Q
T
M
A
E
L
T
N
K
--
P
S
S
E
I
F
I
Q
D
L
L
A
--------
V
D
T
S
V
P
V
S
V
T
G
G
L
A
G
E
F
S
L
E
Q
A
V
G
I
A
S
M
V
K
S
D
R
L
Q
M
A
M
I
A
R
E
I
E
Q
K
L
N
I
D
V
Q
I
G
G
A
E
A
E
A
A
I
L
G
A
--
L
T
T
---
P
-------
G
T
T
R
P
L
A
I
L
D
L
G
A
G
S
T
D
A
S
I
I
N
--
P
K
--
G
D
--
I
---
I
-----
A
--
T
---
H
L
A
G
A
G
D
M
V
T
M
I
I
A
R
E
L
G
---------
L
E
------------------
D
-----------
R
-------------------
Y
L
A
E
E
I
K
K
Y
P
L
A
K
V
E
S
L
F
H
-
L
-
R
H
--
E
D
G
--
S
V
Q
F
F
S
T
P
L
P
P
A
V
F
A
R
V
C
V
V
K
A
D
E
L
V
P
L
P
G
D
L
A
L
E
K
V
R
A
I
R
---
R
S
--
A
K
E
R
V
F
V
T
N
A
L
R
A
L
R
Q
V
S
P
T
G
N
I
R
D
I
P
F
V
V
L
V
G
G
S
S
L
D
F
E
V
P
Q
L
V
T
D
A
L
A
H
Y
R
L
V
A
G
--------
R
G
-----
N
I
-------------
R
G
S
E
---
G
P
R
N
A
V
A
T
G
L
I
L
S
--------------------
2
PsiBlast_PDB
97.91
70%
-105
- C6 -
2D0P
4
DDRFA_KLEOK
A:
[1-601]
M
R
Y
I
A
G
I
D
I
G
N
S
S
T
E
V
A
L
A
T
L
D
E
A
G
A
L
T
I
T
H
S
A
L
A
E
T
T
G
I
K
-
G
T
L
R
N
V
F
G
I
Q
E
A
L
A
L
V
A
R
G
A
G
I
A
V
S
D
I
S
L
I
R
I
N
E
A
T
P
V
I
G
D
V
A
M
E
T
I
T
E
T
I
I
T
E
--
S
T
M
I
G
H
N
P
K
T
P
G
G
A
G
L
G
T
G
I
T
I
T
P
Q
E
L
L
T
--
R
P
A
---
D
A
---
P
-
Y
I
L
V
V
S
S
A
F
D
F
A
-
D
I
A
S
V
I
N
-----
A
S
L
R
A
G
Y
Q
I
T
G
V
I
L
Q
R
D
D
G
V
L
V
S
N
R
L
E
K
P
L
P
I
V
D
E
V
L
Y
I
D
R
I
P
L
G
M
L
A
A
I
E
V
A
V
P
G
K
V
I
E
T
L
S
N
---
P
Y
G
I
A
T
V
F
N
L
S
P
E
E
T
K
N
I
V
P
M
A
R
A
L
I
G
N
R
S
A
V
V
V
K
T
P
S
G
D
V
K
A
R
A
I
P
A
G
N
L
E
L
L
A
Q
G
R
S
V
R
V
D
V
A
A
G
A
E
A
I
M
K
A
V
D
G
C
G
R
L
D
N
V
T
G
E
S
G
T
N
I
G
G
M
L
E
H
V
R
Q
T
M
A
E
L
T
N
K
--
P
S
S
E
I
F
I
Q
D
L
L
A
--------
V
D
T
S
V
P
V
S
V
T
G
G
L
A
G
E
F
S
L
E
Q
A
V
G
I
A
S
M
V
K
S
D
R
L
Q
M
A
M
I
A
R
E
I
E
Q
K
L
N
I
D
V
Q
I
G
G
A
E
A
E
A
A
I
L
G
A
--
L
T
T
---
P
-------
G
T
T
R
P
L
A
I
L
D
L
G
A
G
S
T
D
A
S
I
I
N
--
P
K
--
G
D
--
I
---
I
-----
A
--
T
---
H
L
A
G
A
G
D
M
V
T
M
I
I
A
R
E
L
G
---------
L
E
------------------
D
-----------
R
-------------------
Y
L
A
E
E
I
K
K
Y
P
L
A
K
V
E
S
L
F
H
-
L
-
R
H
--
E
D
G
--
S
V
Q
F
F
S
T
P
L
P
P
A
V
F
A
R
V
C
V
V
K
A
D
E
L
V
P
L
P
G
D
L
A
L
E
K
V
R
A
I
R
---
R
S
--
A
K
E
R
V
F
V
T
N
A
L
R
A
L
R
Q
V
S
P
T
G
N
I
R
D
I
P
F
V
V
L
V
G
G
S
S
L
D
F
E
V
P
Q
L
V
T
D
A
L
A
H
Y
R
L
V
A
G
--------
R
G
-----
N
I
-------------
R
G
S
E
---
G
P
R
N
A
V
A
T
G
L
I
L
S
--------------------
9
PsiBlast_CBE
97.18
70%
-106
- C6 -
2D0P
3
DDRFA_KLEOK
C:
[1-601]
M
R
Y
I
A
G
I
D
I
G
N
S
S
T
E
V
A
L
A
T
L
D
E
A
G
A
L
T
I
T
H
S
A
L
A
E
T
T
G
I
K
-
G
T
L
R
N
V
F
G
I
Q
E
A
L
A
L
V
A
R
G
A
G
I
A
V
S
D
I
S
L
I
R
I
N
E
A
T
P
V
I
G
D
V
A
M
E
T
I
T
E
T
I
I
T
E
--
S
T
M
I
G
H
N
P
K
T
P
G
G
A
G
L
G
T
G
I
T
I
T
P
Q
E
L
L
T
--
R
P
A
---
D
A
---
P
-
Y
I
L
V
V
S
S
A
F
D
F
A
-
D
I
A
S
V
I
N
-----
A
S
L
R
A
G
Y
Q
I
T
G
V
I
L
Q
R
D
D
G
V
L
V
S
N
R
L
E
K
P
L
P
I
V
D
E
V
L
Y
I
D
R
I
P
L
G
M
L
A
A
I
E
V
A
V
P
G
K
V
I
E
T
L
S
N
---
P
Y
G
I
A
T
V
F
N
L
S
P
E
E
T
K
N
I
V
P
M
A
R
A
L
I
G
N
R
S
A
V
V
V
K
T
P
S
G
D
V
K
A
R
A
I
P
A
G
N
L
E
L
L
A
Q
G
R
S
V
R
V
D
V
A
A
G
A
E
A
I
M
K
A
V
D
G
C
G
R
L
D
N
V
T
G
E
S
G
T
N
I
G
G
M
L
E
H
V
R
Q
T
M
A
E
L
T
N
K
--
P
S
S
E
I
F
I
Q
D
L
L
A
--------
V
D
T
S
V
P
V
S
V
T
G
G
L
A
G
E
F
S
L
E
Q
A
V
G
I
A
S
M
V
K
S
D
R
L
Q
M
A
M
I
A
R
E
I
E
Q
K
L
N
I
D
V
Q
I
G
G
A
E
A
E
A
A
I
L
G
A
--
L
T
T
---
P
-------
G
T
T
R
P
L
A
I
L
D
L
G
A
G
S
T
D
A
S
I
I
N
--
P
K
--
G
D
--
I
---
I
-----
A
--
T
---
H
L
A
G
A
G
D
M
V
T
M
I
I
A
R
E
L
G
---------
L
E
------------------
D
-----------
R
-------------------
Y
L
A
E
E
I
K
K
Y
P
L
A
K
V
E
S
L
F
H
-
L
-
R
H
--
E
D
G
--
S
V
Q
F
F
S
T
P
L
P
P
A
V
F
A
R
V
C
V
V
K
A
D
E
L
V
P
L
P
G
D
L
A
L
E
K
V
R
A
I
R
---
R
S
--
A
K
E
R
V
F
V
T
N
A
L
R
A
L
R
Q
V
S
P
T
G
N
I
R
D
I
P
F
V
V
L
V
G
G
S
S
L
D
F
E
V
P
Q
L
V
T
D
A
L
A
H
Y
R
L
V
A
G
--------
R
G
-----
N
I
-------------
R
G
S
E
---
G
P
R
N
A
V
A
T
G
L
I
L
S
--------------------
32
Fugue
94.72
60%
-106
- C6 -
1NBW
1
?
A:
[2-607]
-
P
L
I
A
G
I
D
I
G
N
A
T
T
E
V
A
L
A
S
-
D
Y
P
Q
A
R
A
F
V
A
S
G
I
V
A
T
T
G
M
K
-
G
T
R
D
N
I
A
G
T
L
A
A
L
E
Q
A
L
A
K
T
P
W
S
M
S
D
V
S
R
I
Y
L
N
E
A
A
P
V
I
G
D
V
A
M
E
T
I
T
E
T
I
I
T
E
--
S
T
M
I
G
H
N
P
Q
T
P
G
G
V
G
V
G
V
G
T
T
I
A
L
G
R
L
A
T
--
L
P
A
---
A
Q
YAE
G
-
W
I
V
L
I
D
D
A
V
D
F
L
-
D
A
V
W
W
L
N
-----
E
A
L
D
R
G
I
N
V
V
A
A
I
L
K
K
D
D
G
V
L
V
N
N
R
L
R
K
T
L
P
V
V
D
E
V
T
L
L
E
Q
V
P
E
G
V
M
A
A
V
E
V
A
A
P
G
Q
V
V
R
I
L
S
N
---
P
Y
G
I
A
T
F
F
G
L
S
P
E
E
T
Q
A
I
V
P
I
A
R
A
L
I
G
N
R
S
A
V
V
L
K
T
P
Q
G
D
V
Q
S
R
V
I
P
A
G
N
L
Y
I
S
G
E
K
R
R
G
E
A
D
V
A
E
G
A
E
A
I
M
Q
A
M
S
A
C
A
P
V
R
D
I
R
G
E
P
G
T
H
A
G
G
M
L
E
R
V
R
K
V
M
A
S
L
T
G
H
--
E
M
S
A
I
Y
I
Q
D
L
L
A
--------
V
D
T
F
I
P
R
K
V
Q
G
G
M
A
G
E
C
A
M
E
N
A
V
G
M
A
A
M
V
K
A
D
R
L
Q
M
Q
V
I
A
R
E
L
S
A
R
L
Q
T
E
V
V
V
G
G
V
E
A
N
M
A
I
A
G
A
--
L
T
T
---
P
-------
G
C
A
A
P
L
A
I
L
D
L
G
A
G
S
T
D
A
A
I
V
N
--
A
E
--
G
Q
--
I
---
T
-----
A
--
V
---
H
L
A
G
A
G
N
M
V
S
L
L
I
K
T
E
L
G
---------
L
E
------------------
D
-----------
L
-------------------
S
L
A
E
A
I
K
K
Y
P
L
A
K
V
E
S
L
F
S
-
I
-
R
H
--
E
N
G
--
A
V
E
F
F
R
E
A
L
S
P
A
V
F
A
K
V
V
Y
I
K
E
G
E
L
V
P
I
D
N
A
S
P
L
E
K
I
R
L
V
R
---
R
Q
--
A
K
E
K
V
F
V
T
N
C
L
R
A
L
R
Q
V
S
P
G
G
S
I
R
D
I
A
F
V
V
L
V
G
G
S
S
L
D
F
E
I
P
Q
L
I
T
E
A
L
S
H
Y
G
V
V
A
G
--------
Q
G
-----
N
I
-------------
R
G
T
E
---
G
P
R
N
A
V
A
T
G
L
L
L
A
G
Q
A
N
----------------
12
HHSearch
94.19
61%
-108
- C6 -
1NBW
1
?
A:
[2-606]
-
P
L
I
A
G
I
D
I
G
N
A
T
T
E
V
A
L
A
S
D
Y
P
-
Q
A
R
A
F
V
A
S
G
I
V
A
T
T
G
M
K
-
G
T
R
D
N
I
A
G
T
L
A
A
L
E
Q
A
L
A
K
T
P
W
S
M
S
D
V
S
R
I
Y
L
N
E
A
A
P
V
I
G
D
V
A
M
E
T
I
T
E
T
I
I
T
E
--
S
T
M
I
G
H
N
P
Q
T
P
G
G
V
G
V
G
V
G
T
T
I
A
L
G
R
L
A
T
--
L
P
A
AQY
A
E
---
G
-
W
I
V
L
I
D
D
A
V
D
F
L
-
D
A
V
W
W
L
N
-----
E
A
L
D
R
G
I
N
V
V
A
A
I
L
K
K
D
D
G
V
L
V
N
N
R
L
R
K
T
L
P
V
V
D
E
V
T
L
L
E
Q
V
P
E
G
V
M
A
A
V
E
V
A
A
P
G
Q
V
V
R
I
L
S
N
---
P
Y
G
I
A
T
F
F
G
L
S
P
E
E
T
Q
A
I
V
P
I
A
R
A
L
I
G
N
R
S
A
V
V
L
K
T
P
Q
G
D
V
Q
S
R
V
I
P
A
G
N
L
Y
I
S
G
E
K
R
R
G
E
A
D
V
A
E
G
A
E
A
I
M
Q
A
M
S
A
C
A
P
V
R
D
I
R
G
E
P
G
T
H
A
G
G
M
L
E
R
V
R
K
V
M
A
S
L
T
G
H
--
E
M
S
A
I
Y
I
Q
D
L
L
A
--------
V
D
T
F
I
P
R
K
V
Q
G
G
M
A
G
E
C
A
M
E
N
A
V
G
M
A
A
M
V
K
A
D
R
L
Q
M
Q
V
I
A
R
E
L
S
A
R
L
Q
T
E
V
V
V
G
G
V
E
A
N
M
A
I
A
G
A
--
L
T
T
---
P
-------
G
C
A
A
P
L
A
I
L
D
L
G
A
G
S
T
D
A
A
I
V
N
--
A
E
--
G
Q
--
I
---
T
-----
A
--
V
---
H
L
A
G
A
G
N
M
V
S
L
L
I
K
T
E
L
G
---------
L
E
------------------
D
-----------
L
-------------------
S
L
A
E
A
I
K
K
Y
P
L
A
K
V
E
S
L
F
S
-
I
-
R
H
--
E
N
G
--
A
V
E
F
F
R
E
A
L
S
P
A
V
F
A
K
V
V
Y
I
K
E
G
E
L
V
P
I
D
N
A
S
P
L
E
K
I
R
L
V
R
---
R
Q
--
A
K
E
K
V
F
V
T
N
C
L
R
A
L
R
Q
V
S
P
G
G
S
I
R
D
I
A
F
V
V
L
V
G
G
S
S
L
D
F
E
I
P
Q
L
I
T
E
A
L
S
H
Y
G
V
V
A
G
--------
Q
G
-----
N
I
-------------
R
G
T
E
---
G
P
R
N
A
V
A
T
G
L
L
L
A
G
Q
A
-----------------
3
PsiBlast_PDB
94.09
60%
-106
- C6 -
1NBW
1
?
A:
[2-607]
-
P
L
I
A
G
I
D
I
G
N
A
T
T
E
V
A
L
A
-
S
D
Y
P
Q
A
R
A
F
V
A
S
G
I
V
A
T
T
G
M
K
-
G
T
R
D
N
I
A
G
T
L
A
A
L
E
Q
A
L
A
K
T
P
W
S
M
S
D
V
S
R
I
Y
L
N
E
A
A
P
V
I
G
D
V
A
M
E
T
I
T
E
T
I
I
T
E
--
S
T
M
I
G
H
N
P
Q
T
P
G
G
V
G
V
G
V
G
T
T
I
A
L
G
R
L
A
T
LP
A
A
Q
---
Y
A
---
E
G
W
I
V
L
I
D
D
A
V
D
F
L
-
D
A
V
W
W
L
N
-----
E
A
L
D
R
G
I
N
V
V
A
A
I
L
K
K
D
D
G
V
L
V
N
N
R
L
R
K
T
L
P
V
V
D
E
V
T
L
L
E
Q
V
P
E
G
V
M
A
A
V
E
V
A
A
P
G
Q
V
V
R
I
L
S
N
---
P
Y
G
I
A
T
F
F
G
L
S
P
E
E
T
Q
A
I
V
P
I
A
R
A
L
I
G
N
R
S
A
V
V
L
K
T
P
Q
G
D
V
Q
S
R
V
I
P
A
G
N
L
Y
I
S
G
E
K
R
R
G
E
A
D
V
A
E
G
A
E
A
I
M
Q
A
M
S
A
C
A
P
V
R
D
I
R
G
E
P
G
T
H
A
G
G
M
L
E
R
V
R
K
V
M
A
S
L
T
G
H
--
E
M
S
A
I
Y
I
Q
D
L
L
A
--------
V
D
T
F
I
P
R
K
V
Q
G
G
M
A
G
E
C
A
M
E
N
A
V
G
M
A
A
M
V
K
A
D
R
L
Q
M
Q
V
I
A
R
E
L
S
A
R
L
Q
T
E
V
V
V
G
G
V
E
A
N
M
A
I
A
G
A
--
L
T
T
---
P
-------
G
C
A
A
P
L
A
I
L
D
L
G
A
G
S
T
D
A
A
I
V
N
--
A
E
--
G
Q
--
I
---
T
-----
A
--
V
---
H
L
A
G
A
G
N
M
V
S
L
L
I
K
T
E
L
G
---------
L
E
------------------
D
-----------
L
-------------------
S
L
A
E
A
I
K
K
Y
P
L
A
K
V
E
S
L
F
S
-
I
-
R
H
--
E
N
G
--
A
V
E
F
F
R
E
A
L
S
P
A
V
F
A
K
V
V
Y
I
K
E
G
E
L
V
P
I
D
N
A
S
P
L
E
K
I
R
L
V
R
---
R
Q
--
A
K
E
K
V
F
V
T
N
C
L
R
A
L
R
Q
V
S
P
G
G
S
I
R
D
I
A
F
V
V
L
V
G
G
S
S
L
D
F
E
I
P
Q
L
I
T
E
A
L
S
H
Y
G
V
V
A
G
--------
Q
G
-----
N
I
-------------
R
G
T
E
---
G
P
R
N
A
V
A
T
G
L
L
L
A
G
Q
A
N
----------------
11
PsiBlast_CBE
93.94
60%
-109
- C6 -
1NBW
1
?
C:
[3-606]
--
L
I
A
G
I
D
I
G
N
A
T
T
E
V
A
L
A
-
S
D
Y
P
Q
A
R
A
F
V
A
S
G
I
V
A
T
T
G
M
K
-
G
T
R
D
N
I
A
G
T
L
A
A
L
E
Q
A
L
A
K
T
P
W
S
M
S
D
V
S
R
I
Y
L
N
E
A
A
P
V
I
G
D
V
A
M
E
T
I
T
E
T
I
I
T
E
--
S
T
M
I
G
H
N
P
Q
T
P
G
G
V
G
V
G
V
G
T
T
I
A
L
G
R
L
A
T
LP
A
A
Q
---
Y
A
---
E
G
W
I
V
L
I
D
D
A
V
D
F
L
-
D
A
V
W
W
L
N
-----
E
A
L
D
R
G
I
N
V
V
A
A
I
L
K
K
D
D
G
V
L
V
N
N
R
L
R
K
T
L
P
V
V
D
E
V
T
L
L
E
Q
V
P
E
G
V
M
A
A
V
E
V
A
A
P
G
Q
V
V
R
I
L
S
N
---
P
Y
G
I
A
T
F
F
G
L
S
P
E
E
T
Q
A
I
V
P
I
A
R
A
L
I
G
N
R
S
A
V
V
L
K
T
P
Q
G
D
V
Q
S
R
V
I
P
A
G
N
L
Y
I
S
G
E
K
R
R
G
E
A
D
V
A
E
G
A
E
A
I
M
Q
A
M
S
A
C
A
P
V
R
D
I
R
G
E
P
G
T
H
A
G
G
M
L
E
R
V
R
K
V
M
A
S
L
T
G
H
--
E
M
S
A
I
Y
I
Q
D
L
L
A
--------
V
D
T
F
I
P
R
K
V
Q
G
G
M
A
G
E
C
A
M
E
N
A
V
G
M
A
A
M
V
K
A
D
R
L
Q
M
Q
V
I
A
R
E
L
S
A
R
L
Q
T
E
V
V
V
G
G
V
E
A
N
M
A
I
A
G
A
--
L
T
T
---
P
-------
G
C
A
A
P
L
A
I
L
D
L
G
A
G
S
T
D
A
A
I
V
N
--
A
E
--
G
Q
--
I
---
T
-----
A
--
V
---
H
L
A
G
A
G
N
M
V
S
L
L
I
K
T
E
L
G
---------
L
E
------------------
D
-----------
L
-------------------
S
L
A
E
A
I
K
K
Y
P
L
A
K
V
E
S
L
F
S
-
I
-
R
H
--
E
N
G
--
A
V
E
F
F
R
E
A
L
S
P
A
V
F
A
K
V
V
Y
I
K
E
G
E
L
V
P
I
D
N
A
S
P
L
E
K
I
R
L
V
R
---
R
Q
--
A
K
E
K
V
F
V
T
N
C
L
R
A
L
R
Q
V
S
P
G
G
S
I
R
D
I
A
F
V
V
L
V
G
G
S
S
L
D
F
E
I
P
Q
L
I
T
E
A
L
S
H
Y
G
V
V
A
G
--------
Q
G
-----
N
I
-------------
R
G
T
E
---
G
P
R
N
A
V
A
T
G
L
L
L
A
G
Q
A
-----------------
15
HHSearch
42.75
19%
-60
- C6 -
2YCH
3
?
A:
[140-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
Q
V
M
V
A
A
A
R
Q
E
A
V
A
G
V
L
E
A
L
----
R
G
A
G
L
V
P
V
V
L
D
V
K
P
F
A
G
L
Y
P
L
E
A
R
L
A
---
E
-------
E
P
D
R
V
F
L
V
L
D
I
G
A
E
S
T
S
L
V
L
L
R
--
G
D
--
K
P
--
L
---
A
-----
V
--
R
---
V
L
T
L
S
G
K
D
F
T
E
A
I
A
R
S
F
N
---------
L
D
------------------------------
L
-------------------
L
A
A
E
E
V
K
R
T
Y
-------------------------------------------------------
G
R
I
Y
D
A
I
---
R
P
--
V
L
V
E
-
L
T
Q
E
L
R
R
S
L
E
F
F
R
I
Q
L
---
S
P
E
V
G
Y
L
L
G
G
G
S
K
L
R
G
L
A
S
L
L
T
D
T
L
G
-
V
N
L
E
P
V
--------
N
P
-----
W
E
A
V
A
V
D
PKRFE
S
E
Q
L
Q
E
I
---
G
P
E
F
A
V
A
L
G
L
A
L
R
G
V
E
-----------------
21
HHSearch
40.98
19%
-43
- C6 -
3D2F
3
?
A:
[154-388]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
N
I
A
D
A
A
R
-
I
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
--
G
I
F
---
K
TDLPEGE
E
K
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
K
G
--
Q
L
--
K
V
L
G
T
-----
A
--
C
---
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
---------
D
E
F
K
T
K
YKI-----------
D
IREN
P
K
A
Y
N
R
I
L
-------------------
T
A
A
E
K
L
K
K
V
L
S
A
N
T
N
A
P
------------------
F
S
V
E
S
V
M
--
N
D
V
----------
D
V
S
S
Q
L
S
R
E
E
L
E
E
L
V
---
K
P
--
L
L
E
R
-
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
--
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
K
-
P
--------------------
L
-------------
S
T
T
L
---
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
-----------------
40
Fugue
40.83
14%
-35
- C1 -
4XDN
5
SCC4_YEAST
A:
[24-640]
-------
G
D
K
L
S
I
S
Q
V
Y
H
L
A
Q
E
Y
R
D
H
A
Y
S
I
A
N
K
I
G
S
E
E
G
L
K
-
Q
Y
Y
G
L
M
N
M
S
I
Q
M
F
Q
L
L
K
T
K
C
T
L
S
V
L
E
D
S
K
V
T
F
E
M
V
E
L
L
I
Q
E
T
Y
N
F
D
L
A
E
L
Y
I
S
S
L
K
E
R
L
Q
T
H
Q
S
D
T
D
L
V
E
E
I
M
R
C
E
F
L
L
L
H
D
L
P
L
--
M
R
D
---
S
K
---
F
-
H
Y
K
I
A
L
R
N
C
N
---
E
L
V
Q
Y
M
V
-----
N
L
Q
D
E
L
Y
Q
N
W
A
S
V
F
Q
Y
V
G
V
M
L
C
I
K
L
K
Q
H
R
R
V
K
T
S
F
H
G
L
L
S
Q
C
R
E
K
--
S
Q
W
K
W
F
L
N
L
C
Y
V
N
Y
L
L
N
E
RF
P
I
P
E
D
A
L
Q
E
L
R
S
T
E
L
H
T
V
G
P
E
L
Y
A
W
K
L
A
L
E
M
V
I
Q
L
C
K
D
G
N
I
T
D
H
L
N
E
F
K
N
F
F
D
T
N
K
Q
S
L
V
T
N
E
G
K
G
C
V
I
K
I
M
P
R
I
A
L
K
V
E
L
P
M
I
F
H
Y
K
E
L
K
N
I
L
L
L
L
Q
S
V
S
Y
I
V
N
C
Y
D
---
E
K
G
N
F
S
R
K
F
L
P
K
--------
V
Y
S
T
T
Q
K
L
I
K
N
I
A
A
G
G
V
S
M
N
E
L
D
S
R
I
Q
T
Y
K
S
I
L
E
F
C
E
F
Y
K
V
W
E
Q
T
L
L
K
G
A
V
V
L
G
P
S
P
G
Y
V
R
L
L
Q
A
--
M
K
V
---
Q
F
E
GG---
G
A
V
E
E
Y
T
R
L
A
Q
S
G
G
T
S
S
E
V
K
M
I
--
S
L
--
L
N
--
C
---
Y
-----
T
--
V
---
Q
A
A
R
V
S
R
C
S
--------
G
---------
D
K
------------------
Q
-----------
G
-------------------
E
L
V
E
Q
C
N
K
V
-
W
L
Q
V
E
K
L
L
Q
--------
E
T
--
D
L
Q
F
-
N
P
I
W
E
C
T
V
T
I
L
W
L
F
S
H
F
E
P
F
S
W
N
P
L
P
C
S
-
D
K
Q
R
A
E
Y
---
V
S
--
K
L
R
E
F
Y
S
S
N
--
K
F
V
N
R
F
K
L
K
K
A
L
L
L
Q
I
L
V
N
Y
L
G
G
R
M
L
E
H
D
L
G
E
I
Y
A
I
S
A
K
C
F
D
M
C
R
Q
--------
Q
G
-----
G
M
-------------
R
K
V
Q
Y
V
I
G
I
W
H
L
M
N
C
T
V
A
M
R
G
K
D
V
A
L
T
N
A
K
L
E
A
L
V
K
Q
I
T
S
19
HHSearch
40.75
22%
-54
- C6 -
2V7Y
2
DNAK_GEOKA
A:
[125-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
A
T
K
D
A
G
R
-
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
--
G
L
D
---
K
-------
E
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
--
L
G
--
D
G
--
V
---
F
E
V
K
A
T
A
--
G
---
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
---------
N
Q
F
K
Q
E
HGI-----------
D
LSKD
K
M
A
L
Q
R
L
K
-------------------
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
T
Q
------------------
I
S
L
P
F
I
S
A
--
N
------
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
---
A
H
--
L
V
E
R
-
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
--
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
K
-
E
--------------------
P
-------------
H
K
G
V
---
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
------------------
20
HHSearch
40.31
16%
-57
- C6 -
3QFU
3
GRP78_YEAST
A:
[170-393]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
T
K
D
A
G
T
-
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
--
G
L
D
K--
S
-------
D
K
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
--
I
E
--
N
G
--
V
---
F
EVQ
A
T
S
--
G
---
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
---------
K
A
------------------------------
F
K
K
K
HGIDVSDN
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
S
T
------------------
R
I
E
I
D
S
F
V
--
D
G
I
----------
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
---
L
D
--
L
F
K
K
-
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
--
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
K
K
--------------------
A
-------------
S
K
G
I
---
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
----------------
23
HHSearch
39.85
19%
-48
- C6 -
3I33
3
HSP72_HUMAN
A:
[176-399]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
K
D
A
G
T
-
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
--
G
L
D
---
K
KGCA---
G
G
E
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
G
--
I
F
--
E
---
V
-----
K
--
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
---------
E
E
F
K
R
K
HKKDIGPN
K
R
A
V
R
R
L
-----------
R
-------------------
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
-------------
A
--
S
---
I
E
I
D
S
L
Y
--
E
G
----------
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
---
A
D
--
L
F
R
G
-
T
L
E
P
V
E
K
A
L
R
D
A
K
L
--
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
---------------------------------
N
K
S
I
---
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
------------------
34
Fugue
39.77
9%
-53
- C6 -
1E4F
-
?
T:
[7-390]
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
K
R
D
Q
-
E
W
E
A
L
A
F
S
S
V
K
S
R
G
L
D
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
----------
K
S
L
R
S
D
F
V
I
S
F
S
S
V
S
F
E
R
E
--
D
T
V
I
E
R
D
F
G
E
E
K
R
S
I
T
L
D
I
L
S
E
M
Q
S
E
A
L
E
--
K
L
K
---
E
N
---
G
-
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
I
V
F
NPLDM
K
A
S
K
I
A
I
E
Y
T
S
I
V
V
P
L
K
V
Y
E
M
F
Y
N
F
L
Q
D
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
T
A
E
G
V
L
T
T
P
E
K
D
R
G
V
V
V
V
N
L
G
Y
---
N
F
T
G
L
I
A
Y
K
N
G
V
P
I
K
I
S
Y
V
P
V
G
M
K
H
V
I
K
D
V
S
A
V
L
D
T
S
F
E
E
S
E
R
L
I
I
T
H
G
N
A
V
-
Y
N
D
L
K
E
E
E
I
Q
Y
R
G
L
D
G
N
T
I
K
T
T
T
----
A
K
K
L
S
V
I
I
H
A
R
L
R
E
I
M
S
K
S
K
K
F
F
R
E
V
E
A
K
IG
I
P
G
G
V
V
L
T
G
G
G
A
KIPRINEL
A
T
E
V
F
K
S
P
V
R
T
G
C
Y
A
N
S
D
R
P
S
I
I
N
A
D
E
V
A
N
D
P
S
F
A
A
A
F
G
N
V
F
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
39.41
17%
-44
- C6 -
3WT0
1
FTSA_STAAW
A:
[168-390]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
K
V
E
A
G
V
I
A
I
Q
K
S
I
L
I
N
M
I
K
C
V
----
E
A
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
-
S
I
--
L
T
A
---
T
-------
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
E
--
R
G
--
E
L
--
V
---
D
-----
A
--
D
---
S
I
E
M
A
G
R
D
I
T
D
D
I
A
Q
G
L
N
---------
T
S
------------------------------
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
A
S
-------
D
Q
D
--
I
---
F
T
V
E
------
Q
V
------
D
--
S
D
E
T
V
Q
Y
T
Q
K
D
L
S
D
F
I
---
E
A
R
-
V
E
E
--
I
F
F
E
V
F
D
V
L
Q
D
L
G
L
T
---
K
V
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
-
E
K
V
R
I
H
--------
T
P
-----
S
Q
-------------
M
G
I
R
---
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
----------------
28
HHSearch
39.20
19%
-57
* C6 *
2FSJ
1
ACTH_THEAC
A:
[162-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
T
R
L
I
M
R
P
Q
G
V
G
A
A
L
Y
L
--
L
N
Q
---
G
I
I
E
----
Q
Q
P
G
Y
G
V
V
I
D
V
G
S
R
T
T
D
V
L
T
I
N
--
L
M
DM
E
P
VV
E
---
L
-----
S
--
F
---
S
L
Q
I
G
V
G
D
A
I
S
A
L
S
R
K
I
A
---------
K
E
TGFVV-------------
P
-----------
F
-------------------
D
L
A
Q
E
A
L
S
H
P
-----------------------------
V
--
M
F
R
Q
K
--------
Q
V
G
----
G
-
P
E
V
S
G
P
I
L
---
E
D
--
L
A
N
R
-
I
I
E
N
I
R
L
N
L
R
G
E
-----
V
D
R
V
T
S
L
I
P
V
G
G
G
S
N
L
--
I
G
D
R
F
E
E
I
A
P
G
T
L
V
K
--------------------------------
I
K
P
E
---
D
L
Q
F
A
N
A
L
G
Y
R
D
A
A
E
R
-----------------
24
HHSearch
38.69
15%
-56
- C6 -
1K8K
-
ARP3_BOVIN
A:
[121-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
R
E
Y
T
A
E
I
M
F
E
S
F
N
V
P
G
L
Y
I
A
V
Q
A
V
L
A
L
A
A
S
--
W
T
S
RQV
G
-------
E
R
T
L
T
G
T
V
I
D
S
G
D
G
V
T
H
V
I
P
V
A
--
E
G
--
Y
V
--
I
---
G
-----
S
C
I
K
---
H
I
P
I
A
G
R
D
I
T
Y
F
I
Q
Q
L
L
R
D
REVGIPPE
Q
S
------------------------------
L
-------------------
E
T
A
K
A
V
K
E
R
Y
S
Y
V
C
P
D
L
V
K
E
F
N
K
Y
D
-
T
D
G
SK
W
I
K
Q
Y
T
G
I
N
A
I
S
K
K
E
F
S
I
D
V
G
Y
E
R
F
L
------
G
P
E
I
F
F
H
P
E
FAN
P
D
--
F
T
Q
P
-
I
S
E
V
V
D
E
V
I
Q
N
C
P
I
D
V
R
R
P
L
Y
K
N
I
V
L
S
G
G
S
T
M
F
R
D
F
G
R
R
L
Q
R
D
L
K
R
-
T
V
D
A
R
L
K
L
S
E
E
L
S
K
P
K
P
I
D
V
Q
V
-------------
I
T
H
H
---
M
Q
R
Y
A
V
W
F
G
G
S
M
L
A
S
------------------
26
HHSearch
37.42
17%
-47
- C6 -
3DWL
1
ARP3_SCHPO
A:
[139-395]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
N
T
A
E
I
M
F
E
S
F
N
C
A
G
L
Y
I
A
V
Q
A
V
L
A
L
A
A
S
--
W
T
S
---
S
KVT----
D
R
S
L
T
G
T
V
V
D
S
G
D
G
V
T
H
I
I
P
V
A
--
E
G
--
Y
V
--
I
---
G
-----
S
SI
K
---
T
M
P
L
A
G
R
D
V
T
Y
F
V
Q
S
L
L
R
-----------------------------------------
L
-------------------
K
T
A
E
R
I
K
E
E
C
C
Y
V
C
P
D
I
V
K
E
F
S
R
F
DR-------
L
K
Y
A
S
----------
I
D
V
G
F
E
R
F
L
------
A
P
E
I
F
F
N
P
E
---
I
A
SS
D
F
L
T
P
L
P
E
L
V
D
N
V
V
Q
S
S
P
I
D
V
R
K
G
L
Y
K
N
I
V
L
S
G
G
S
T
L
F
K
N
F
G
N
R
L
Q
R
D
L
K
R
I
-
V
D
E
R
G
V
------
D
V
-----
N
V
-------------
I
S
H
K
---
R
Q
R
N
A
V
W
F
G
G
S
L
L
A
Q
------------------