@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1166: (2016-03-22 )
MNSFQIKTKVAFGTNSLQVLKEIKNKNVWIICDRFLADGEGLQGLIGQLDASNNVHIFTDVVPDPPISKVAGGVSEAGKIQPQVMIAFGGGSAIDTAKGIYYFAKRLEKINISTFIAIPTTSGTGSEVTAATVITDPTTKIKYPLFLDELIPDMAILDAQLVVTVPPAITANTGMDVLTHAIEAYVSKDASDYTDALGEKSVQLTLRFLTSCYDDGRNLADREKMHNASTMAGMAFNCANLGLNHSIAHQLGAQFHVPHGLANAILLDAVIRFNAFKNRETEQKYAEMARICGIASRSDSNETAVRLLRERIVAMMEHMQMPRTLTDAGVAKEKVYAKMDEIATNALKDACLPTSPTTPTHQELKEILEQII
Atome Classification :
(21 SA)
.........10........20.--.----...------..---..30..---...---...40........50...-...-...60........70........80........90........100--------....------.....-------------110----------....-------------....-----120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270...--....280.......290.......300.--.....--.310.......320---........330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
S
F
Q
I
K
T
K
V
A
FGT
N
S
L
Q
V
L
-
K
--
E
----
I
KN------K
N
---
V
W
I
I
C
D
---
R
FL---ADGE
G
L
Q
G
L
I
GQLD-ASN-
N
V
H
-
I
F
TDVVPDP
P
I
S
K
V
AGGVSEAGKIQ
P
Q
V
M
I
A
FGGGSAIDTA
K
G
I
----------
Y
Y
F
A
------
K
R
L
E
K-------------IN-----------
I
S
T
F
-------------
I
A
I
P-----TTSGTGS
E
V
T
A
A
T
V
ITDPTTKIKY
P
L
F
L
D
E
LIP
D
M
A
ILD
A
Q
L
V
V
TVPPAITANT
G
M
D
V
L
T
H
A
I
E
A
Y
V
SKDAS
D
Y
T
D
A
LGE
K
S
V
Q
L
T
L
R
F
L
T
S
C
Y
DDGRN
L
A
D
R
E
K
MHNA
S
T
M
A
G
M
A
F
N
C
A
NLGL
N
H
S
I
A
H
Q
LGAQFHVP
H
G
L
A
N
A
I
L
L
D
A
V
I
R
F
NA--FKN
R
E
T
E
Q
K
Y
A
E
M
A
R
I
CGIASRSDS
N
E
T
--
A
V
R
L
L
--
R
E
R
I
V
A
M
M
E
H
MQM----PRTLTDAGV
A
K
E
K
V
Y
A
K
M
D
E
I
A
T
N
A
L
K
DACLPTSPTTP
T
H
Q
E
L
K
E
I
L
E
QII
51
HHSearch
97.05
35%
-92
- C2 -
3BFJ
1
DHAT_KLEPN
A:
[7-387]
--
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
-
G
E
-
R
C
Q
L
-
L
G
G
------
K
K
---
A
L
L
V
T
D
---
K
G
L
---
R
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
-
E
V
A
-
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
----------
G
I
A
A
------
T
H
E
G
D
LYQYAGIETLT--
N
P
-----------
L
P
P
I
-------------
V
A
V
N
-----
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
--
I
A
---
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
T
G
L
S
T
L
D
--
A
A
E
K
A
--
I
A
A
I
T
R
L
S
M
D
I
G
I
----
P
Q
H
L
R
D
L
G
V
K
E
----
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
50
HHSearch
95.92
34%
-91
- C2 -
1RRM
4
FUCO_ECOLI
A:
[4-383]
-
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
-
T
D
-
E
V
K
R
-
R
G
Y
------
Q
K
---
A
L
I
V
T
D
---
K
T
L
---
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
-
A
W
A
-
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
----------
G
I
I
S
------
N
N
P
E
F
ADVRSLEGLSPTN
K
P
-----------
S
V
P
I
-------------
L
A
I
P
-----
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
--
D
F
---
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
--
A
R
N
A
A
--
V
E
A
V
F
A
L
N
R
D
V
G
I
----
P
P
H
L
R
D
V
G
V
R
K
----
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
40
PsiBlast_CBE
95.06
32%
-92
- C2 -
2BL4
2
FUCO_ECOLI
B:
[13-387]
-
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
--
E
----
V
K
R
------
R
G
YQK
A
L
I
V
T
D
---
K
T
L
---
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
-
A
A
G
-
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
----------
G
I
I
S
------
N
N
P
E
F
-------------
A
D
-----------
V
R
S
L
EGLSPTNKPSVPI
L
A
I
P
-----
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
--
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
-----
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
--
A
R
N
A
A
--
V
E
A
V
F
A
L
N
R
D
V
G
I
----
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
----
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
-----
41
PsiBlast_CBE
94.51
32%
-95
- C2 -
2BI4
2
FUCO_ECOLI
B:
[13-387]
-
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
--
E
----
V
K
R
------
R
G
YQK
A
L
I
V
T
D
---
K
T
L
---
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
-
A
A
G
-
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
----------
G
I
I
S
------
N
N
P
E
F
-------------
A
D
-----------
V
R
S
L
EGLSPTNKPSVPI
L
A
I
P
-----
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
--
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
-----
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
--
A
R
N
A
A
--
V
E
A
V
F
A
L
N
R
D
V
G
I
----
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
----
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
-----
2
PsiBlast_PDB
94.35
32%
-93
- C2 -
2BI4
3
FUCO_ECOLI
A:
[13-387]
-
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
--
E
----
V
K
R
------
R
G
YQ
K
A
L
I
V
T
D
---
K
T
L
---
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
-
A
A
G
-
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
----------
G
I
I
S
------
N
N
P
E
F
-------------
A
D
-----------
V
R
S
L
EGLSPTNKPSV
P
I
L
A
I
P
-----
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
--
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
-----
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
--
A
R
N
A
A
--
V
E
A
V
F
A
L
N
R
D
V
G
I
----
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
----
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
-----
3
PsiBlast_PDB
94.18
32%
-92
- C2 -
2BL4
3
FUCO_ECOLI
A:
[13-387]
-
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
--
E
----
V
K
R
------
R
G
Y
Q
K
A
L
I
V
T
D
---
K
T
L
---
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
-
A
A
G
-
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
----------
G
I
I
S
------
N
N
P
E
F
-------------
A
D
-----------
V
R
S
L
EGLSPTNKPSV
P
I
L
A
I
P
-----
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
--
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
-----
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
--
A
R
N
A
A
--
V
E
A
V
F
A
L
N
R
D
V
G
I
----
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
----
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
-----
48
HHSearch
87.11
31%
-89
* C2 *
3OX4
2
ADH2_ZYMMO
A:
[5-383]
--
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
-
I
K
D
L
NG--
S
G
F
------
K
N
---
A
L
I
V
S
D
---
A
F
M
---
N
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
-
N
S
A
-
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
----------
A
L
V
A
------
T
N
G
G
E
VKDYEGIDKSK--
K
P
-----------
A
L
P
L
-------------
M
S
I
N
-----
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
--
S
V
---
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
--
G
A
E
A
T
--
I
Q
A
V
R
D
L
A
A
S
I
G
I
----
P
A
N
L
T
E
L
G
A
K
K
----
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
6
PsiBlast_PDB
85.63
32%
-80
- C2 -
4FR2
1
?
A:
[45-396]
--------------------------------------
K
K
---
P
V
I
V
T
D
---
K
F
L
E
N
L
K
N
G
A
V
A
Q
T
L
A
S
L
K
K
-
S
G
V
-
D
Y
V
-
V
Y
N
G
V
E
P
N
P
K
I
H
N
I
K
E
V
K
T
L
Y
E
K
E
D
A
D
S
I
I
T
V
G
G
G
S
A
H
D
T
G
K
G
A
----------
G
I
I
M
------
T
N
G
D
D
-------------
I
T
KLAGIETLKNP
L
P
P
L
-------------
I
A
V
N
-----
T
T
A
G
T
G
S
E
L
T
R
H
A
V
I
T
N
E
E
T
H
L
K
F
V
V
V
S
W
R
N
I
P
L
V
S
F
N
D
P
T
L
M
L
D
I
P
K
G
L
T
A
A
T
G
M
D
A
F
V
Q
A
V
E
P
Y
V
S
V
D
H
N
P
I
T
D
S
Q
C
I
Q
A
I
K
L
I
E
S
S
L
R
E
A
V
A
N
G
H
N
L
Q
A
R
T
K
M
V
E
A
E
M
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Q
Y
D
A
P
H
G
V
C
C
A
L
L
L
P
Y
A
E
E
Y
N
L
--
I
A
D
P
E
---
R
F
A
E
L
A
R
I
M
G
E
N
T
D
G
L
S
T
R
D
--
A
A
E
L
S
--
I
K
A
M
K
Q
L
S
E
D
V
G
I
----
P
H
S
I
K
D
I
G
A
K
P
E
----
D
F
D
L
M
A
E
N
A
L
K
D
G
N
A
F
S
N
P
R
K
G
T
K
E
D
I
V
K
I
F
Q
E
--
36
PsiBlast_CBE
85.41
36%
-77
- C2 -
3BFJ
1
DHAT_KLEPN
E:
[16-385]
-----------
F
G
P
N
A
I
S
V
V
-
G
--
E
RCQL
L
G
G
------
K
K
---
A
L
L
V
T
D
KGL
R
-----
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
-
A
G
I
-
E
V
A
-
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
GIAATHEGDL
Y
Q
Y
A
------
G
I
E
T
L
-------------
T
N
P----------
L
P
P
I
-------------
V
A
V
N
-----
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
--
I
A
N
P
E
---
K
F
A
D
I
A
E
L
M
G
------
E
N
I
T
--
G
L
S
T
L
DA
A
E
K
A
I
A
A
I
T
R
L
S
M
DIGI
P
Q
H
L
R
D
L
G
V
-
K
E
T
D
F
P
Y
M
A
E
M
---
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
--
39
PsiBlast_CBE
84.62
36%
-73
- C2 -
3BFJ
1
DHAT_KLEPN
B:
[16-385]
-----------
F
G
P
N
A
I
S
V
V
-
G
--
E
RCQL
L
G
G
------
K
K
---
A
L
L
V
T
D
KGL
R
-----
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
-
A
G
I
-
E
V
A
-
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
GIAATHEGDL
Y
Q
Y
A
------
G
I
E
T
L
-------------
T
N
P----------
L
P
P
I
-------------
V
A
V
N
-----
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
--
I
A
N
P
E
---
K
F
A
D
I
A
E
L
M
G
------
E
N
I
T
--
G
L
S
T
L
DA
A
E
K
A
I
A
A
I
T
R
L
S
M
DIGI
P
Q
H
L
R
D
L
G
V
-
K
E
T
D
F
P
Y
M
A
E
M
---
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
--
37
PsiBlast_CBE
84.39
36%
-73
- C2 -
3BFJ
1
DHAT_KLEPN
D:
[16-385]
-----------
F
G
P
N
A
I
S
V
V
-
G
--
E
RCQL
L
G
G
------
K
K
---
A
L
L
V
T
D
KGL
R
-----
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
-
A
G
I
-
E
V
A
-
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
GIAATHEGDL
Y
Q
Y
A
------
G
I
E
T
L
-------------
T
N
P----------
L
P
P
I
-------------
V
A
V
N
-----
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
--
I
A
N
P
E
---
K
F
A
D
I
A
E
L
M
G
------
E
N
I
T
--
G
L
S
T
L
DA
A
E
K
A
I
A
A
I
T
R
L
S
M
DIGI
P
Q
H
L
R
D
L
G
V
-
K
E
T
D
F
P
Y
M
A
E
M
---
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
--
38
PsiBlast_CBE
83.82
36%
-73
- C2 -
3BFJ
1
DHAT_KLEPN
C:
[16-385]
-----------
F
G
P
N
A
I
S
V
V
-
G
--
E
RCQL
L
G
G
------
K
K
---
A
L
L
V
T
D
KGL
R
-----
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
-
A
G
I
-
E
V
A
-
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
GIAATHEGDL
Y
Q
Y
A
------
G
I
E
T
L
-------------
T
N
P----------
L
P
P
I
-------------
V
A
V
N
-----
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
--
I
A
N
P
E
---
K
F
A
D
I
A
E
L
M
G
------
E
N
I
T
--
G
L
S
T
L
DA
A
E
K
A
I
A
A
I
T
R
L
S
M
DIGI
P
Q
H
L
R
D
L
G
V
-
K
E
T
D
F
P
Y
M
A
E
M
---
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
--
1
PsiBlast_PDB
83.70
36%
-74
- C2 -
3BFJ
1
DHAT_KLEPN
A:
[16-385]
-----------
F
G
P
N
A
I
S
V
V
-
G
--
E
R
C
Q
L
L
G
G
------
K
K
---
A
L
L
V
T
D
KGL
R
-----
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
-
A
G
I
-
E
V
A
-
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
HEGDL
Y
Q
Y
A
------
G
I
E
T
L
-------------
T
N
P----------
L
P
P
I
-------------
V
A
V
N
-----
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
--
I
A
N
P
E
---
K
F
A
D
I
A
E
L
M
G
------
E
N
I
T
--
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
GI
P
Q
H
L
R
D
L
G
V
-
K
E
T
D
F
P
Y
M
A
E
M
---
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
--
4
PsiBlast_PDB
82.03
33%
-72
- C2 -
3OWO
1
ADH2_ZYMMO
A:
[4-379]
-
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
---
K
--
A
----
I
K
D
L
NGSGF
K
N
---
A
L
I
V
S
D
---
A
F
M
---
N
K
S
G
V
V
K
Q
V
A
D
L
L
K
-
A
Q
G
I
N
S
A
-
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
----------
A
L
V
A
T
NGGEV
K
D
Y
E
G
-------------
I
D
-----------
K
S
K
K
-------------
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
SV
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
--
A
A
S
I
-------
G
I
----
P
A
N
L
T
E
L
G
A
K
K
E
D
V
----
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
----
44
PsiBlast_CBE
81.92
33%
-72
- C2 -
3OX4
2
ADH2_ZYMMO
B:
[4-379]
-
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
---
K
--
A
----
I
K
D
LNGSGF
K
N
---
A
L
I
V
S
D
---
A
F
M
---
N
K
S
G
V
V
K
Q
V
A
D
L
L
K
-
A
Q
G
I
N
S
A
-
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
----------
A
L
V
A
TNGGEV
K
D
Y
E
G
-------------
I
D
-----------
K
S
K
K
-------------
P
A
L
P
LMSIN
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
SV
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
IQ
A
V
R
D
L
--
A
A
S
I
-------
G
I
----
P
A
N
L
T
E
L
G
A
K
K
E
D
V
----
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
----
47
PsiBlast_CBE
81.89
33%
-71
- C2 -
3OWO
1
ADH2_ZYMMO
B:
[4-379]
-
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
---
K
--
A
----
I
K
D
LNGSGF
K
N
---
A
L
I
V
S
D
---
A
F
M
---
N
K
S
G
V
V
K
Q
V
A
D
L
L
K
-
A
Q
G
I
N
S
A
-
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
----------
A
L
V
A
TNGGEV
K
D
Y
E
G
-------------
I
D
-----------
K
S
K
K
-------------
P
A
L
P
LMSIN
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
SV
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
IQ
A
V
R
D
L
--
A
A
S
I
-------
G
I
----
P
A
N
L
T
E
L
G
A
K
K
E
D
V
----
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
----
21
PsiBlast_CBE
81.77
36%
-72
- C2 -
3BFJ
14
DHAT_KLEPN
T:
[16-385]
-----------
F
G
P
N
A
I
S
V
V
-
G
--
E
RCQL
L
G
G
------
K
K
---
A
L
L
V
T
D
KGL
R
-----
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
-
A
G
I
-
E
V
A
-
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
GIAATHEGDL
Y
Q
Y
A
------
G
I
E
T
L
-------------
T
N
P----------
L
P
P
I
-------------
V
A
V
N
-----
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
--
I
A
N
P
E
---
K
F
A
D
I
A
E
L
M
G
------
E
N
I
T
--
G
L
S
T
L
DA
A
E
K
A
I
A
A
I
T
R
L
S
M
DIGI
P
Q
H
L
R
D
L
G
V
-
K
E
T
D
F
P
Y
M
A
E
M
---
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
--
45
PsiBlast_CBE
81.63
33%
-71
- C2 -
3OWO
1
ADH2_ZYMMO
D:
[4-379]
-
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
---
K
--
A
----
I
K
D
LNGSGF
K
N
---
A
L
I
V
S
D
---
A
F
M
---
N
K
S
G
V
V
K
Q
V
A
D
L
L
K
-
A
Q
G
I
N
S
A
-
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
----------
A
L
V
A
TNGGEV
K
D
Y
E
G
-------------
I
D
-----------
K
S
K
K
-------------
P
A
L
P
LMSIN
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
SV
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
IQ
A
V
R
D
L
--
A
A
S
I
-------
G
I
----
P
A
N
L
T
E
L
G
A
K
K
E
D
V
----
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
----
35
PsiBlast_CBE
81.57
36%
-73
- C2 -
3BFJ
1
DHAT_KLEPN
F:
[16-385]
-----------
F
G
P
N
A
I
S
V
V
-
G
--
E
RCQL
L
G
G
------
K
K
---
A
L
L
V
T
D
KGL
R
-----
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
-
A
G
I
-
E
V
A
-
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
GIAATHEGDL
Y
Q
Y
A
------
G
I
E
T
L
-------------
T
N
P----------
L
P
P
I
-------------
V
A
V
N
-----
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
--
I
A
N
P
E
---
K
F
A
D
I
A
E
L
M
G
------
E
N
I
T
--
G
L
S
T
L
DA
A
E
K
A
I
A
A
I
T
R
L
S
M
DIGI
P
Q
H
L
R
D
L
G
V
-
K
E
T
D
F
P
Y
M
A
E
M
---
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
--
43
PsiBlast_CBE
80.91
33%
-69
- C2 -
3OX4
2
ADH2_ZYMMO
C:
[4-379]
-
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
---
K
--
A
----
I
K
D
LNGSGF
K
N
---
A
L
I
V
S
D
---
A
F
M
---
N
K
S
G
V
V
K
Q
V
A
D
L
L
K
-
A
Q
G
I
N
S
A
-
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
----------
A
L
V
A
TNGGEV
K
D
Y
E
G
-------------
I
D
-----------
K
S
K
K
-------------
P
A
L
P
LMSIN
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
SV
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
IQ
A
V
R
D
L
--
A
A
S
I
-------
G
I
----
P
A
N
L
T
E
L
G
A
K
K
E
D
V
----
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
----
7
PsiBlast_PDB
80.31
34%
-74
- C2 -
1RRM
4
FUCO_ECOLI
A:
[64-378]
---------------------------------------------------------------------------------
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
----------
G
I
I
S
------
N
N
P
E
F
-------------
A
D
-----------
V
R
S
L
EGLSPTNKPSV
P
I
L
A
I
P
-----
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
E
E
M
A
L
--
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
-----
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
--
A
R
N
A
A
--
V
E
A
V
F
A
L
N
R
D
V
G
I
----
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
----
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
-----