@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1179: (2016-03-22 )
VALEDKDLRSIQEVRNLIESANKAQKELAAMSQQQIDTIVKAIADAGYGAREKLAKMAHEETGFGIWQDKVIKNVFASKHVYNYIKDMKTIGMLKEDNEKKVMEVAVPLGVVAGLIPSTNPTSTVIYKTLISIKAGNSIVFSPHPNALKAILETVRIISEAAEKAGCPKGAISCMTVPTIQGTDQLMKHKDTAVILATGGSAMVKAAYSSGTPAIGVGPGNGPAFIERSANIPRAVKHILDSKTFDNGTICASEQSVVVERVNKEAVIAEFRKQGAHFLSDAEAVQLGKFILRPNGSMNPAIVGKSVQHIANLAGLTVPADARVLIAEETKVGAKIPYSREKLAPILAFYTAETWQEACELSMDILYHEGAGHTLIIHSEDKEIIREFALKKPVSRLLVNTPGALGGIGATTNLVPALTLGCGAVGGSSSSDNIGPENLFNIRRIATGVLELEDIRKEENQATSELPVDADALIQSLVEKVLAELK
Atome Classification :
(20 SA)
----......----------...10........20.....--...30........40........50........60..--......70.--.......80......-.-.--90..---.--.--.------...--------.100....-...110.......120-........130.......140.......150..-.....160.......170.......---180.......190.......200...-----..----.------.----------210------.......220.......230...--....240.......250.......260-.......270...---------------.----------------.----------------..280--------------.......290.......300-.......310.......320.-------......330.....-.-.------------.340..-.....350.--......360.......370.......380-.---........--390.......400.......410...--....420.-......430.-.......440.......450.......460.......470.......480....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----VAL
E
D
K
----------
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
--
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
DAGY
G
A
R
E
K
L
A
K
M
AHEETG--FG
I
W
Q
D
K
V
I
--
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
-
M
-
K
--
T
-IG---M--L--K------EDN--------E
K
K
V
M
E
V
A
-
V
P
L
G
V
V
A
G
LIPSTNP--
T
S
T
V
I
Y
K
T
L
I
S
I
KAG
N
S
I
V
FSPH
P
N
A
L
K
A
I
L
E
T
-
V
R
I
I
S
E
A
A
E
KAGCPKG
A
I
S
C
M
T
VPT---IQ
G
T
D
Q
L
M
KHKD
T
A
V
I
L
ATGGS
A
M
V
K
-----
A
A----Y------S----------SGT------P
A
I
G
VGPGN
G
P
A
F
I
ERSAN
I
P
R
A
--
V
K
H
I
LDSKTFDN
G
T
I
CAS
E
Q
S
V
V
V
E
RV-
N
K
E
A
V
I
A
E
F
R
K
QG---------------A----------------H----------------FLS
D
A
--------------
E
A
V
Q
L
G
K
F
I
LRPNGSM
N
P
A
I
-
V
G
K
S
V
Q
H
I
A
N
L
AGLTVPAD
A
R
-------
V
L
I
A
EET-KVGAKI-P-Y------------
S
R
E
K
L
A
-
P
I
L
A
F
Y
T
A
E
--
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
HEGAG
H
T
L
I
I
HSE---
D
---
K
E
I
I
R
E
F
A
--
L
KK
P
V
S
R
L
LVNTPGALGGIGATTNL
V
--
P
A
L
T
LGCG-AVGGSSS-SD-NI
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
K
E
ENQATSELPV
D
A
D
A
L
I
Q
S
L
V
E
K
V
L
A
ELK
21
PsiBlast_CBE
99.24
99%
-93
- C3 -
3K9D
2
?
C:
[4-457]
-------
E
D
K
----------
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
--
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
--
F
G
I
W
Q
D
K
V
I
--
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
-
M
-
K
--
T
-
I
G
---
M
--
L
--
K
------
E
D
N
--------
E
K
K
V
M
E
V
A
-
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
--
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
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T
-
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
---
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
-----
A
A
----
Y
------
S
----------
S
G
T
------
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
--
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
-
N
K
E
A
V
I
A
E
F
R
K
Q
G
---------------
A
----------------
H
----------------
F
L
S
D
A
--------------
E
A
V
Q
L
G
K
F
I
L
R
P
N
G
S
M
N
P
A
I
-
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
-------
V
L
I
A
E
E
T
-
K
V
G
A
K
I
-
P
-
Y
------------
S
R
E
K
L
A
-
P
I
L
A
F
Y
T
A
E
--
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
---
D
---
K
E
I
I
R
E
F
A
--
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
L
V
--
P
A
L
T
L
G
C
G
-
A
V
G
G
S
S
S
-
S
D
-
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
E
-----------------------------
43
Fugue
98.08
100%
-90
- C3 -
3K9D
1
?
A:
[3-456]
------
L
E
D
K
----------
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
--
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
--
F
G
I
W
Q
D
K
V
I
--
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
-
M
-
K
--
T
-
I
G
---
M
--
L
--
K
------
E
D
N
--------
E
K
K
V
M
E
V
A
-
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
--
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
-
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
---
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
-----
A
A
----
Y
------
S
----------
S
G
T
------
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
--
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
-
N
K
E
A
V
I
A
E
F
R
K
Q
G
---------------
A
----------------
H
----------------
F
L
S
D
A
--------------
E
A
V
Q
L
G
K
F
I
L
R
P
N
G
S
M
N
P
A
I
-
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
-------
V
L
I
A
E
E
T
-
K
V
G
A
K
I
-
P
-
Y
------------
S
R
E
K
L
A
-
P
I
L
A
F
Y
T
A
E
--
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
---
D
---
K
E
I
I
R
E
F
A
--
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
L
V
--
P
A
L
T
L
G
C
G
-
A
V
G
G
S
S
S
-
S
D
-
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
------------------------------
1
PsiBlast_PDB
97.86
99%
-90
- C3 -
3K9D
1
?
A:
[3-456]
------
L
E
D
K
----------
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
--
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
--
F
G
I
W
Q
D
K
V
I
--
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
-
M
-
K
--
T
-
I
G
---
M
--
L
--
K
------
E
D
N
--------
E
K
K
V
M
E
V
A
-
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
--
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
-
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
---
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
-----
A
A
----
Y
------
S
----------
S
G
T
------
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
--
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
-
N
K
E
A
V
I
A
E
F
R
K
Q
G
---------------
A
----------------
H
----------------
F
L
S
D
A
--------------
E
A
V
Q
L
G
K
F
I
L
R
P
N
G
S
M
N
P
A
I
-
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
-------
V
L
I
A
E
E
T
-
K
V
G
A
K
I
-
P
-
Y
------------
S
R
E
K
L
A
-
P
I
L
A
F
Y
T
A
E
--
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
---
D
---
K
E
I
I
R
E
F
A
--
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
L
V
--
P
A
L
T
L
G
C
G
-
A
V
G
G
S
S
S
-
S
D
-
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
------------------------------
22
PsiBlast_CBE
97.26
99%
-91
- C3 -
3K9D
1
?
B:
[3-456]
------
L
E
D
K
----------
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
--
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
--
F
G
I
W
Q
D
K
V
I
--
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
-
M
-
K
--
T
-
I
G
---
M
--
L
--
K
------
E
D
N
--------
E
K
K
V
M
E
V
A
-
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
--
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
-
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
---
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
-----
A
A
----
Y
------
S
----------
S
G
T
------
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
--
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
-
N
K
E
A
V
I
A
E
F
R
K
Q
G
---------------
A
----------------
H
----------------
F
L
S
D
A
--------------
E
A
V
Q
L
G
K
F
I
L
R
P
N
G
S
M
N
P
A
I
-
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
-------
V
L
I
A
E
E
T
-
K
V
G
A
K
I
-
P
-
Y
------------
S
R
E
K
L
A
-
P
I
L
A
F
Y
T
A
E
--
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
---
D
---
K
E
I
I
R
E
F
A
--
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
L
V
--
P
A
L
T
L
G
C
G
-
A
V
G
G
S
S
S
-
S
D
-
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
------------------------------
24
HHSearch
91.07
94%
-85
- C3 -
3K9D
1
?
A:
[3-451]
------
L
E
D
K
----------
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
--
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
--
F
G
I
W
Q
D
K
V
I
--
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
-
M
-
K
--
T
-
I
G
---
M
--
L
--
K
------
E
D
N
--------
E
K
K
V
M
E
V
A
-
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
--
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
-
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
---
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
-----
A
A
----
Y
------
S
----------
S
G
T
------
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
--
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
-
N
K
E
A
V
I
A
E
F
R
K
Q
G
---------------
A
----------------
H
----------------
F
L
S
D
A
--------------
E
A
V
Q
L
G
K
F
I
L
R
P
N
G
S
M
N
P
A
I
-
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
-------
V
L
I
A
E
E
T
-
K
V
G
A
K
I
-
P
-
Y
------------
S
R
E
K
L
A
-
P
I
L
A
F
Y
T
A
E
--
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
---
D
---
K
E
I
I
R
E
F
A
--
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
L
V
PA
L
T
L
G
C
G
A
V
G
G
S
S
S
S
D
N
-
I
G
-
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
--------------------------------------
2
PsiBlast_PDB
72.75
43%
-85
- C3 -
3MY7
1
?
A:
[8-446]
--------------------------
E
L
D
A
M
I
A
R
V
K
K
A
Q
E
--
E
F
A
T
Y
S
Q
E
Q
V
D
K
I
F
R
A
A
S
L
A
A
N
Q
A
R
I
P
L
A
Q
Q
A
V
E
E
S
G
--
M
G
I
V
E
D
K
V
I
--
K
N
H
F
A
S
E
F
I
Y
N
K
Y
K
D
-
E
-
Q
--
T
-
C
G
---
I
--
L
-----------------------
T
M
T
I
A
-
E
P
V
G
I
I
C
G
I
V
P
T
T
N
P
--
T
S
T
A
I
F
K
S
L
I
S
L
K
T
R
N
G
I
I
F
S
P
H
P
R
A
K
N
S
T
N
D
A
-
A
K
L
V
L
D
A
A
V
A
A
G
A
P
K
D
I
I
G
W
I
D
Q
P
S
---
V
E
L
S
N
A
L
M
K
H
D
D
I
A
L
I
L
A
T
G
G
P
G
M
V
K
-----
A
A
----
Y
------
S
----------
S
G
K
------
P
A
I
G
V
G
--
N
V
P
V
V
I
D
E
T
A
D
I
K
R
A
--
V
A
S
V
L
M
S
K
T
F
D
N
G
V
V
C
A
S
E
Q
A
V
I
V
V
D
E
-
V
Y
D
E
V
K
E
R
F
A
S
H
K
---------------
A
----------------
H
----------------
V
L
S
K
T
--------------
D
A
D
K
V
R
K
V
L
L
I
-
D
G
A
L
N
A
K
I
-
V
G
Q
P
A
T
A
I
A
E
M
A
G
V
K
V
P
A
D
T
K
-------
V
L
I
G
E
G
L
G
K
V
S
Y
D
D
-
A
-
F
------------
A
H
E
K
L
S
-
P
T
L
G
M
F
R
A
D
--
N
F
E
D
A
V
A
Q
A
V
T
M
V
E
I
G
G
I
G
H
T
S
G
L
Y
T
N
QDV
N
---
A
D
R
I
R
Y
F
G
--
D
K
M
K
T
A
R
I
L
I
N
I
P
T
T
------------------------------
S
E
-
N
V
G
P
K
H
L
I
N
K
K
T
V
A
----------------------------------------
40
HHSearch
64.88
41%
-71
- C3 -
3MY7
1
?
A:
[2-449]
--------------------
P
V
T
N
M
A
E
L
D
A
M
I
A
R
V
K
K
A
Q
E
--
E
F
A
T
Y
S
Q
E
Q
V
D
K
I
F
R
A
A
S
L
A
A
N
Q
A
R
I
P
L
A
Q
Q
A
V
E
E
S
G
--
M
G
I
V
E
D
K
V
I
--
K
N
H
F
A
S
E
F
I
Y
N
K
Y
K
D
-
E
-
Q
--
T
-
C
G
---
I
--
L
-----------------------
T
M
T
I
A
-
E
P
V
G
I
I
C
G
I
V
P
T
T
N
P
--
T
S
T
A
I
F
K
S
L
I
S
L
K
T
R
N
G
I
I
F
S
P
H
P
R
A
K
N
S
T
N
D
A
-
A
K
L
V
L
D
A
A
V
A
A
G
A
P
K
D
I
I
G
W
I
D
Q
P
S
---
V
E
L
S
N
A
L
M
K
H
D
D
I
A
L
I
L
A
T
G
G
P
G
M
V
K
-----
A
A
----
Y
------
S
----------
S
G
K
------
P
A
I
G
V
G
--
N
V
P
V
V
I
D
E
T
A
D
I
K
R
A
--
V
A
S
V
L
M
S
K
T
F
D
N
G
V
V
C
A
S
E
Q
A
V
I
V
V
D
E
-
V
Y
D
E
V
K
E
R
F
A
S
H
K
---------------
A
----------------
H
----------------
V
L
S
K
T
D
A
D
K
V
R
K
V
L
L
IDGA
L
N
A
K
I
V
G
Q
P
A
T
A
I
A
--------
E
M
A
G
V
K
V
P
A
D
T
K
V
L
I
G
E
G
----------
L
----
G
-
K
V
S
Y
D
D
-
A
-
F
------------
A
H
E
K
L
S
-
P
T
L
G
M
F
R
A
D
--
N
F
E
D
A
V
A
Q
A
V
T
M
V
E
I
G
G
I
G
H
T
S
G
L
Y
T
N
---
Q
DVN
A
D
R
I
R
Y
F
G
--
D
K
M
K
T
A
R
I
L
I
N
I
P
T
T
------------------------------
S
E
-
N
V
G
P
K
H
L
I
N
K
K
T
V
A
K
R
A
-------------------------------------
25
HHSearch
54.59
19%
-56
- C3 -
3I44
1
?
A:
[54-496]
------
C
A
V
I
----------
S
L
G
S
T
R
D
A
D
K
A
I
N
A
A
K
K
A
F
Q
--
T
W
K
T
T
S
P
H
E
R
L
G
F
V
E
K
I
L
E
I
Y
E
K
R
S
S
D
M
A
K
T
I
S
M
E
M
G
--
A
P
I
D
M
A
L
N
A
--
Q
T
A
T
G
S
S
H
I
R
N
F
I
K
A
-
Y
-
K
E
F
S
-
F
Q
---
E
--
A
--
L
------
I
E
G
--------
N
E
Q
A
I
L
H
Y
-
D
A
I
G
V
V
G
L
I
T
P
W
N
W
P
--
M
N
Q
V
T
L
K
V
I
P
A
L
L
A
G
C
T
M
V
L
K
P
S
E
I
A
P
L
S
A
M
L
F
-
A
E
I
L
----
D
E
A
A
L
P
S
G
V
F
N
L
I
N
G
D
G
---
A
N
V
G
S
Y
L
S
A
H
P
D
L
E
M
I
S
F
T
G
S
T
R
A
G
K
-----
D
I
----
S
K
N
A
S--
N
----------
T
L
K
------
R
V
C
L
E
L
G
G
K
G
A
N
I
I
F
A
D
A
D
I
D
A
L
--
Q
-
R
G
V
R
H
C
F
Y
N
S
G
Q
S
C
N
A
P
T
R
M
L
V
E
Q
A
-
I
Y
D
K
A
I
K
T
A
K
D
I
A
E
K
T
Q
V
G
P
GHQTGN
H
I
G
----------------
P
----------------
V
V
S
K
E
--------------
Q
Y
D
K
I
Q
D
L
I
Q
S
G
I
D
E
G
A
T
L
V
-
T
G
G
T
G
L
P
M
G
M
E
R
G
Y
Y
V
R
P
T
----------
V
F
---
A
-
D
V
K
P
H
M
-
R
I
F
------------
R
E
E
I
F
G
-
P
V
L
S
L
L
P
F
N
--
T
E
D
E
A
V
T
L
A
N
D
----
T
E
Y
G
L
T
N
Y
I
Q
S
Q
---
D
---
R
S
K
C
R
R
I
A
--
A
Q
V
R
S
G
M
V
E
V
N
G
H
E
L
----------
P
--
G
G
S
Y
F
G
G
V
K
F
S
G
R
A
R
E
-
G
G
-
L
W
G
I
K
E
F
L
D
T
K
A
I
S
Y
---------------------------------------
34
HHSearch
52.08
16%
-54
- C3 -
2J6L
4
AL7A1_HUMAN
A:
[50-498]
------
I
A
R
V
----------
R
Q
A
S
V
A
D
Y
E
E
T
V
K
K
A
R
E
A
W
K
--
I
W
A
D
I
P
A
P
K
R
G
E
I
V
R
Q
I
G
D
A
L
R
E
K
I
Q
V
L
G
S
L
V
S
L
E
M
G
--
K
I
L
V
E
G
V
-
G
--
E
V
Q
E
Y
V
D
I
C
D
Y
A
V
G
L
-
S
-
R
M
-
I
-
G
G
---
P
I-
L
--
P
S-----
E
R
S
--------
G
H
A
L
I
E
Q
W
-
N
P
V
G
L
V
G
I
I
T
A
F
N
F
P
--
V
A
V
Y
G
W
N
N
A
I
A
M
I
C
G
N
V
C
L
W
K
G
A
P
T
T
S
L
I
S
V
A
V
-
T
K
I
I
A
K
V
L
E
D
N
K
L
P
G
A
I
C
S
L
T
C
G
G
----
A
D
I
G
T
A
M
A
K
D
E
R
V
N
L
L
S
F
T
G
S
T
Q
V
G
K
-----
Q
V
----
G
L
M
V
Q
--
E
----------
R
F
G
------
R
S
L
L
E
L
G
G
N
N
A
I
I
A
F
E
D
A
D
L
S
L
V
--
V
P
S
A
L
F
A
A
V
G
T
A
G
Q
R
C
T
T
A
R
R
L
F
I
H
E
S
-
I
H
D
E
V
V
N
R
L
K
K
A
Y
---------------
A
Q
IRVGNPWDPNVL
Y
G
-
P
----------------
L
H
T
K
Q
--------------
A
V
S
M
F
L
G
A
V
E
E
A
K
K
E
-
G
G
T
V
V
Y
G
G
K
V
---
M
D
R
P
G
N
Y
V
E
P
T
----------
I
V
---
T
-
G
L
G
H
D
A
-
S
I
A
------------
H
T
E
T
F
A
-
P
I
L
Y
V
F
K
F
Q
--
N
E
E
E
V
F
A
W
N
N
E
----
V
K
Q
G
L
S
S
S
I
F
T
K
---
D
---
L
G
R
I
F
R
W
L
GP
K
G
S
D
C
G
I
V
N
V
N
I
P
T
S
G
--------
A
E
--
I
G
G
A
F
G
G
E
K
H
T
G
G
G
R
E
-
S
G
-
S
D
A
W
K
Q
Y
M
R
R
S
T
C
T
I
N
--------------------------------------
45
Fugue
51.70
15%
-52
- C3 -
1EZ0
1
ALDH_VIBHA
A:
[5-508]
TD
N
V
F
Y
A
T
N
A
FTG
E
A
L
P
L
AF
P
V
H
T
E
V
E
V
N
Q
A
A
T
A
A
A
K
V
A
R
--
D
F
R
R
L
N
N
S
K
R
A
S
L
L
R
T
I
A
S
E
L
E
A
R
S
D
D
I
I
A
R
A
H
L
E
T
A
LP
E
V
R
L
T
G
E
I
A
--
R
T
A
N
Q
L
R
L
F
A
D
V
V
N
S
-
G
-
S
--
Y
-
H
Q
---
A
--
I
--
L
------
D
T
P
N
PTRAP
L
P
K
P
D
I
R
R
Q
Q
-
I
A
L
G
P
V
A
V
F
G
A
S
N
F
P
LA
F
S
A
A
G
G
D
T
A
S
A
L
A
A
G
C
P
V
I
V
K
G
H
T
A
H
P
G
T
S
Q
I
V
-
A
E
C
I
E
Q
A
L
K
Q
E
Q
L
P
Q
A
I
F
T
L
L
Q
G
N
Q
---
R
A
L
G
Q
A
L
V
S
H
P
E
I
K
A
V
G
F
T
G
S
V
G
G
G
R
-----
A
L
----
F
------
N
----------
L
A
H
E
RP
E
P
I
P
F
Y
G
E
L
G
A
I
N
P
T
F
I
F
P
S
A
M
R
A
K
A
D
L
A
D
Q
F
V
A
S
M
T
M
G
C
G
Q
F
C
T
K
P
G
V
V
F
A
L
----
N
T
P
E
T
Q
A
F
I
E
T
A
---------------
Q
----------------
S
----------------
L
I
R
Q
Q
--------------
S
P
S
T
L
-------
L
T
P
G
I
R
D
S
-
Y
Q
S
Q
V
V
S
R
G
S
D
D
G
I
D
V
T
F
S
Q
A
ESP
C
V
A
S
A
L
F
V
T
S
S
-
E
N
W
R
K
H
-
P
-
A
------------
W
E
E
E
I
F
G
P
Q
S
L
I
V
V
C
E
--
N
V
A
D
M
L
S
L
S
E
M
L
A
G
--
S
L
T
A
T
I
H
A
T
E
E
---
D
---
Y
P
Q
V
S
Q
L
I
P
R
L
E
E
I
A
G
R
L
V
F
N
G
W
P
T
G
V
E
V
G
Y
A
M
V
H
--------------
G
G
P
Y
P
-
A
S
-
T
H
S
A
S
T
S
V
G
A
E
A
I
H
R
W
L
R
P
V
A
Y
Q
A
L
P
E
S
L
L
P
D
S
L
K
A
E
N
P
L
E
I
A
R
A
V
D
G
K
A
A
---
27
HHSearch
51.61
17%
-56
- C3 -
1UZB
5
?
A:
[65-514]
------
V
G
T
T
----------
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
F
K
--
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
--
K
N
W
V
E
A
S
-
A
--
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
-
A
-
L
R
-
Y
-
R
Y
PA
V
E
--
V
--
V
------
P
Y
P
--------
G
E
D
N
E
S
F
Y
-
V
P
L
G
A
G
V
V
I
A
P
W
N
F
P
--
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
-
F
E
I
F
----
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
---
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
-----
K
I
----
Y
------
E
A
A
G
RLAPGQT
W
F
K
------
R
A
Y
V
E
T
G
G
K
N
A
I
I
V
D
E
T
A
D
F
D
L
A
--
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
-
A
Y
E
P
V
L
E
R
V
L
K
R
A
---------------
E
R
LSVGPAEENPDLG--
P
----------------
V
V
S
A
E
--------------
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
-
G
Q
L
V
-
L
G
G
K
R
---
L
E
G
E
G
Y
F
I
A
P
T
----------
V
F
---
T
-
E
V
P
P
K
A
-
R
I
A
------------
Q
E
E
I
F
G
-
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
----
T
P
Y
G
L
T
G
G
V
Y
S
R
---
K
---
R
E
H
L
E
W
A
R
--
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
-------
L
V
--
G
V
Q
P
F
G
G
F
K
L
S
G
T
N
A
K
-
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
---------------------------------------
17
PsiBlast_PDB
51.48
22%
-58
- C3 -
4DNG
-
ALDY_BACSU
A:
[44-449]
-------------------------
K
Q
L
E
D
A
F
D
I
A
Q
K
A
Q
K
--
E
W
A
K
S
T
T
E
D
R
K
A
V
L
Q
K
A
R
G
Y
L
H
E
N
R
D
D
I
I
M
M
I
A
R
E
T
G
--
G
T
I
I
K
S
T
I
E
L
E
Q
T
I
A
I
L
D
E
A
M
T
Y
T
G
E
-
L
-
G
--
G
-
V
K
---
E
--
V
--
P
------
S
D
I
--------
E
G
K
T
N
K
I
Y
R
L
P
L
G
V
I
S
S
I
S
P
F
N
F
P
--
M
N
L
S
M
R
S
I
A
P
A
I
A
L
G
N
S
V
V
H
K
P
D
---
I
Q
T
A
I
S
G
-
G
T
I
I
A
K
A
F
E
H
A
G
L
P
A
G
V
L
N
V
M
L
T
D
V
---
K
E
I
G
D
G
M
L
T
N
P
I
P
R
L
I
S
F
T
G
S
T
A
V
G
R
H
I
G
E
I
A
G
----
R
------
A
----------
F
K
R
------
M
A
L
E
L
G
-
G
N
N
P
F
A
V
L
S
D
A
D
V
D
R
A
--
V
D
A
A
I
F
G
K
F
I
H
Q
----
M
I
I
N
R
I
I
V
H
-----
Q
D
V
Y
D
E
F
V
E
K
--------------------------------------------------
F
T
A
R
V
--------------
K
Q
L
P
Y
G
D
-
Q
T
D
P
K
T
V
V
G
P
L
I
-
N
E
R
Q
I
E
K
A
L
E
I
I
E
-
Q
A
K
T
D
G
I
-------
E
L
A
V
E
G
K
-
R
V
G
N
V
L
T
P
-
Y
V
F
V
GADNNSKIA
Q
T
E
L
F
A
-
P
I
A
T
I
I
K
A
G
--
S
D
Q
E
A
I
D
M
A
N
D
T
E
Y
----
G
L
S
S
A
V
F
T
S
---
D
---
L
E
K
G
E
K
F
A
--
L
Q
----------------------------------------------------------------------------------------------------
35
HHSearch
50.91
18%
-56
- C3 -
3PQA
2
LADH_METJA
A:
[25-464]
------
I
K
K
I
----------
P
A
L
S
R
E
E
A
K
E
A
I
D
T
A
E
K
Y
K
E
--
V
M
K
N
L
P
I
T
K
R
Y
N
I
L
M
N
I
A
K
Q
I
K
E
K
K
E
E
L
A
K
I
L
A
I
D
A
G
--
K
P
I
K
Q
A
R
V
---
E
V
E
R
S
I
G
T
F
K
L
A
A
F
Y
V
K
-
E
--
H
-
R
D
---
E
--
V
--
I
------
P
S
D
--------
D
R
L
I
F
T
R
R
-
E
P
V
G
I
V
G
A
I
T
P
F
N
F
P
--
L
N
L
S
A
H
K
I
A
P
A
I
A
T
G
N
V
I
V
H
H
P
S
S
K
A
P
L
V
C
I
E
L
-
A
K
I
I
E
N
A
L
K
K
Y
N
V
P
L
G
V
Y
N
L
L
T
G
A
G
---
E
V
V
G
D
E
I
V
V
N
E
K
V
N
M
I
S
F
T
G
S
S
K
V
G
E
-----
L
I
----
T
------
K
K
A--------
G
F
K
------
K
I
A
L
E
L
G
G
V
N
P
N
I
V
L
K
D
A
D
L
N
K
A
--
V
N
A
L
I
K
G
S
F
I
Y
A
G
Q
V
C
I
S
V
G
M
I
L
V
D
E
S
-
I
A
D
K
F
I
E
M
F
V
N
K
A
---------------
K
V
LNVGNPLDEKTD
V
G
-
P
----------------
L
I
S
V
E
--------------
H
A
E
W
V
E
K
V
V
E
K
A
I
D
E
G
G
K
L
L
-
L
G
G
K
R
------
D
K
A
L
F
Y
P
T
----------
I
L
-----
E
V
D
R
D
N
-
I
L
C
------------
K
T
E
T
F
A
-
P
V
I
P
I
I
R
T
---
N
E
E
E
M
I
D
I
A
N
S
----
T
E
Y
G
L
H
S
A
I
F
T
N
---
D
---
I
N
K
S
L
K
F
A
--
E
N
L
E
F
G
G
V
V
I
N
D
S
S
L
F
--------
R
Q
--
D
N
M
P
F
G
G
V
K
K
S
G
L
G
R
E
-
G
V
-
K
Y
A
M
E
E
M
S
N
I
K
T
I
I
I
S
K
-------------------------------------
37
HHSearch
50.84
17%
-48
- C3 -
3JU8
14
ASTD_PSEAE
A:
[33-489]
------
V
W
S
G
----------
R
G
A
D
A
T
Q
V
D
A
A
V
C
A
A
R
E
A
F
P
--
A
W
A
R
R
P
L
E
Q
R
I
E
L
L
E
R
F
A
A
T
L
K
S
R
A
D
E
L
A
R
V
I
G
E
E
T
G
--
K
P
L
W
E
S
A
T
---
E
V
T
S
M
V
N
K
V
A
I
S
V
Q
A
-
F
-
R
--
E
R
T
G
---
E
--
K
S
-
G
------
P
L
A
--------
D
A
T
A
V
L
R
H
-
K
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
--
G
H
L
P
N
G
H
I
V
P
A
L
L
A
G
N
C
V
V
F
K
P
S
E
L
T
P
K
V
A
E
L
T
-
L
K
A
W
----
I
Q
A
G
L
P
A
G
V
L
N
L
V
Q
G
G
----
R
E
T
G
V
A
L
A
A
H
R
G
L
D
G
L
F
F
T
G
S
S
R
T
G
N
-----
L
L
----
H
------
S
Q
F
GGQ-----
P
Q
K
------
I
L
A
L
E
M
G
G
N
N
P
L
V
V
E
E
V
A
D
L
D
A
A
--
V
Y
T
I
I
Q
S
A
F
I
S
A
G
Q
R
C
T
C
A
R
R
L
L
V
P
Q
G
A
W
G
D
A
L
L
A
R
L
V
A
V
S
---------------
A
----------------
T
L
R
V
G
R
FDEQPAPF
M
G
A
V
I
S
L
S
--------------
A
A
E
H
L
L
K
A
Q
E
H
L
I
G
K
G
A
Q
P
L
-
L
A
M
T
Q
---
P
I
D
G
A
A
L
L
T
P
G
----------
I
L
-----
D
V
S
A
V
A
-
E
R
P
------------
D
E
E
F
F
G
-
P
L
L
Q
V
I
R
Y
S
--
D
F
A
A
A
I
R
E
A
N
A
----
T
Q
Y
G
L
A
A
G
L
L
S
D
---
S
---
R
E
R
F
E
Q
F
L
--
V
E
S
R
A
G
I
V
N
W
N
K
Q
L
T
G
--------
A
A
--
S
S
A
P
F
G
G
I
G
A
S
G
N
H
R
P
-
S
A
-
Y
Y
A
A
D
Y
C
A
Y
P
V
A
S
L
E
S
P
S
V
S
L
P
A
T
L
T
P
G
I
-------------------------
23
HHSearch
50.49
18%
-52
- C3 -
3U4J
-
?
A:
[52-506]
------
V
G
T
W
----------
P
E
A
S
A
D
D
V
R
K
A
V
A
A
A
R
K
A
F
D
AG
P
W
P
R
M
S
G
A
E
R
S
R
L
M
F
K
V
A
D
L
I
L
A
R
Q
E
E
L
A
L
I
E
S
L
E
V
G
--
K
P
I
A
Q
A
R
G
---
E
I
G
F
C
A
D
L
W
S
Y
A
A
G
Q
-
A
R
A
--
L
-
E
G
---
Q
T
-
H
N-
N
------
I
G
D
--------
D
R
L
G
L
V
L
R
-
E
P
V
G
V
V
G
I
I
T
P
W
N
F
P
--
F
I
I
A
S
E
R
V
P
W
A
I
G
S
G
C
T
V
V
L
K
P
S
E
F
T
S
G
T
S
I
R
L
-
A
E
L
A
----
R
E
A
G
I
P
D
G
V
F
N
V
V
T
G
Y
G
---
D
P
A
G
Q
V
L
A
E
D
P
N
V
D
M
V
A
F
T
G
S
V
R
V
G
T
-----
K
L
G
E
I
A
A
------
R
----------
T
V
K
------
R
V
G
L
E
L
G
G
K
G
P
Q
I
V
F
A
D
A
D
L
D
A
A
--
A
D
G
I
A
Y
G
V
Y
H
N
A
G
Q
C
C
I
S
G
S
R
L
L
V
Q
E
G
-
I
R
D
A
L
M
E
R
L
L
D
I
S
---------------
R
K
V
A
F
G
DPLNERTK
I
G
-
A
----------------
M
I
S
E
A
--------------
H
A
E
K
V
H
S
Y
V
T
A
G
I
T
S
G
A
E
L
L
-
L
G
G
E
R
--
I
G
R
E
A
G
L
Y
Y
A
P
T
----------
V
F
---
A
-
G
V
T
P
D
M
-
S
I
A
------------
R
E
E
I
F
G
-
P
V
L
S
T
L
T
F
K
--
T
A
D
E
A
V
A
L
A
N
A
----
T
E
F
G
L
S
A
S
V
W
S
T
---
N
---
L
E
T
A
L
Q
T
I
--
R
R
I
R
A
G
R
C
W
I
N
S
V
I
D
G
---------
T
--
P
E
L
P
I
G
G
Y
K
K
S
G
L
G
R
E
-
L
G
-
R
Y
G
F
D
E
Y
S
Q
F
K
G
V
H
V
T
L
G
R
P
A
P
W
F
T
-----------------------------
26
HHSearch
50.22
16%
-51
- C3 -
3EK1
2
?
A:
[61-502]
------
I
G
T
V
----------
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
A
K
A
L
S
--
G
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
--
K
P
L
A
E
A
R
G
---
E
V
L
Y
A
A
S
F
I
E
W
F
A
E
E
-
A
K
R
--
V
-
Y
G
---
D
T
-
I
--
P
A-----
P
Q
N
--------
G
Q
R
L
T
V
I
R
-
Q
P
V
G
V
T
A
A
I
T
P
W
N
F
P
--
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
A
L
A
L
-
G
V
L
A
----
E
K
A
G
I
P
A
G
V
L
Q
I
V
T
G
K
A
---
R
E
I
G
A
E
L
T
S
N
D
T
V
R
K
L
S
F
T
G
S
T
E
V
G
R
-----
L
L
----
M
A
Q
C
A--
P
----------
T
I
K
------
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
--
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
-
V
Y
D
K
F
A
E
K
L
A
A
K
V
---------------
K
E
LKVGNGTEPGVVIG-
P
----------------
M
I
E
E
K
--------------
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
-
G
A
K
L
I
T
G
G
K
E
-----
L
G
G
L
F
F
E
P
G
----------
I
L
---
T
-
G
V
T
S
D
M
-
L
V
A
------------
K
E
E
T
F
G
-
P
L
A
P
L
F
A
F
D
--
T
E
E
E
V
I
A
Q
A
N
D
----
T
I
F
G
L
A
A
Y
F
Y
T
E
---
N
---
F
S
R
A
I
R
V
S
--
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
---------
S
N
--
E
V
A
P
F
G
G
V
K
Q
S
G
L
G
R
E
-
G
S
-
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
-------------------------------------
33
HHSearch
49.52
15%
-60
- C3 -
3HAZ
6
?
A:
[542-988]
-------
K
P
I
----------
A
D
A
T
P
D
Q
A
H
A
A
V
A
A
A
R
A
G
F
A
--
G
W
S
R
T
P
A
G
I
R
A
A
A
L
E
Q
A
A
H
L
L
E
S
R
S
A
H
F
I
A
L
L
Q
R
E
G
G
--
K
T
L
D
D
A
L
-
S
--
E
L
R
E
A
A
D
F
C
R
Y
Y
A
A
Q
-
G
R
K
--
L
-
F
G
S
--
E
T
A
M
--
P
------
G
P
T
--------
G
E
S
N
A
L
T
M
-
R
G
R
G
V
F
V
A
I
S
P
W
N
F
P
--
L
A
I
F
L
G
Q
V
T
A
A
L
M
A
G
N
S
V
V
A
K
P
A
E
Q
T
P
R
I
A
R
E
A
-
V
A
L
L
----
H
E
A
G
I
P
K
S
A
L
Y
L
V
T
G
D
G
----
R
I
G
A
A
L
T
A
H
P
D
I
A
G
V
V
F
T
G
S
T
E
V
A
R
-----
S
I
----
N
------
R
A
L
A
A
KDG---
P
I
V
------
P
L
I
A
E
T
G
G
I
N
A
M
I
A
D
A
T
A
L
P
E
Q
V
--
A
D
D
V
V
T
S
A
F
R
S
A
G
Q
R
C
S
A
L
R
L
L
F
V
Q
E
D
-
V
A
D
R
M
I
E
M
V
A
G
A
A
---------------
R
E
LKIGDPSDVATH
V
G
-
P
----------------
V
I
D
V
E
--------------
A
K
Q
R
L
D
A
H
I
A
R
M
K
T
-
E
A
R
L
H
-
F
A
G
P
-----
A
P
E
G
C
F
V
A
P
H
----------
I
F
---
E
--
L
T
E
A
G
-
Q
-
L
------------
T
E
E
V
F
G
-
P
I
L
H
V
V
R
Y
R
PE
N
L
E
R
V
L
R
A
I
E
R
----
T
G
Y
G
L
T
L
G
V
H
S
R
---
I
---
D
D
S
I
E
A
I
I
--
D
R
V
Q
V
G
N
I
Y
V
N
R
N
M
I
G
A
-------
V
V
--
G
V
Q
P
F
G
G
N
G
L
S
G
T
G
P
K
A
G
G
-
P
H
Y
L
A
R
F
A
T
E
Q
T
V
T
I
N
T
A
------------------------------------
30
HHSearch
49.50
18%
-57
* C3 *
3PRL
1
?
A:
[40-483]
------
L
G
S
I
----------
P
A
L
S
Q
E
E
V
N
D
A
I
Q
G
A
K
D
A
Q
K
--
I
W
K
I
R
P
I
H
E
R
V
D
L
L
Y
A
W
A
D
L
L
E
E
R
K
E
I
I
G
E
L
I
M
H
E
V
A
--
K
P
K
K
S
A
I
-
G
--
E
V
S
R
T
A
D
I
I
R
H
T
A
D
E
-
A
L
R
--
L
-
N
G
---
E
--
T
L
-
K
GDQFKG
G
S
S
--------
K
K
I
A
L
V
E
R
-
E
P
L
G
V
V
L
A
I
S
P
F
N
Y
P
--
V
N
L
A
A
A
K
I
A
P
A
L
V
T
G
N
T
V
V
F
K
P
A
T
Q
G
S
L
S
G
I
K
M
-
V
E
A
L
----
A
D
A
G
A
P
E
G
I
I
Q
V
V
T
G
R
G
---
S
V
I
G
D
H
L
V
E
H
P
G
I
D
M
I
T
F
T
G
G
T
T
T
G
E
-----
R
I
----
S
------
E
K
A--------
K
M
I
------
P
V
V
L
E
L
G
G
K
D
P
A
I
V
L
D
D
A
D
L
K
L
T
--
A
S
Q
I
V
S
G
A
F
S
Y
S
G
Q
R
C
T
A
I
K
R
V
F
V
Q
D
S
-
V
A
D
Q
L
V
A
N
I
K
E
L
V
---------------
E
Q
L
T
V
G
S
PEDDADIT--
P
----------------
V
I
D
E
K
--------------
S
A
A
F
I
Q
G
L
I
D
D
A
L
E
-
N
G
A
T
L
L
S
G
N
K
------
R
Q
G
N
L
L
S
P
T
----------
L
L
---
D
-
D
V
T
P
A
M
-
R
V
A
------------
W
E
E
P
F
G
-
P
V
L
P
I
I
R
V
K
--
D
A
N
E
A
I
S
L
S
N
Q
----
S
D
Y
G
L
Q
A
S
I
F
T
K
---
D
---
T
D
R
A
I
N
I
G
--
K
H
L
E
V
G
T
V
H
I
N
A
K
T
E
R
--------
G
P
--
D
H
F
P
F
L
G
V
K
K
S
G
L
G
V
Q
-
G
I
-
K
P
S
L
L
S
M
T
R
E
R
V
T
V
L
N
L
-------------------------------------
28
HHSearch
49.23
20%
-55
- C3 -
3R64
-
?
A:
[41-486]
------
I
A
E
S
----------
K
Q
A
S
I
A
D
V
D
A
A
Y
E
A
A
K
K
A
Q
A
--
E
W
A
A
T
P
A
A
E
R
S
A
I
I
Y
R
A
A
E
L
L
E
E
H
R
E
E
I
V
E
W
L
I
K
E
S
G
--
S
T
R
S
K
A
N
L
---
E
I
T
L
A
G
N
I
T
K
E
S
A
S
F
-
P
G
R
--
V
-
H
G
---
R
--
I
SP
S
------
N
T
P
--------
G
K
E
N
R
V
Y
R
-
V
A
K
G
V
V
G
V
I
S
P
W
N
F
P
--
L
N
L
S
I
R
S
V
A
P
A
L
A
V
G
N
A
V
V
I
K
P
A
S
D
T
P
V
T
G
G
V
I
P
A
R
I
F
----
E
E
A
G
V
P
A
G
V
I
S
T
V
A
G
A
G
---
S
E
I
G
D
H
F
V
T
H
A
V
P
K
L
I
S
F
T
G
S
T
P
V
G
R
-----
R
V
----
G
E
L
A
I
N
G
G
----------
P
M
K
------
T
V
A
L
E
L
G
G
N
A
P
F
V
V
L
A
D
A
D
I
D
A
A
--
A
Q
A
A
A
V
G
A
F
L
H
Q
G
Q
I
C
M
S
I
N
R
V
I
V
D
A
A
-
V
H
D
E
F
L
E
K
F
V
E
A
V
---------------
K
N
I
P
T
G
D
PSAEGTL
V
G
-
P
----------------
V
I
N
D
S
--------------
Q
L
S
G
L
K
E
K
I
E
L
A
K
K
E
-
G
A
T
V
Q
V
E
G
P
------
I
E
G
R
L
V
H
P
H
----------
V
F
---
S
-
D
V
T
S
D
M
-
E
I
A
------------
R
E
E
I
F
G
-
P
L
I
S
V
L
K
A
D
--
D
E
A
H
A
A
E
L
A
N
A
----
S
D
F
G
L
S
A
A
V
W
S
K
---
D
---
I
D
R
A
A
Q
F
A
--
L
Q
I
D
S
G
M
V
H
I
N
D
------------------------------
R
F
-
N
G
-
D
W
A
I
E
E
F
T
T
D
R
W
I
G
I
K
R
S
------------------------------------
42
HHSearch
48.98
16%
-53
- C3 -
2W8N
6
SSDH_HUMAN
A:
[39-485]
------
L
G
M
V
----------
A
D
C
G
V
R
E
A
R
A
A
V
R
A
A
Y
E
A
F
C
--
R
W
R
E
V
S
A
K
E
R
S
S
L
L
R
K
W
Y
N
L
M
I
Q
N
K
D
D
L
A
R
I
I
T
A
E
S
G
--
K
P
L
K
E
A
H
G
---
E
I
L
Y
S
A
F
F
L
E
W
F
S
E
E
-
A
R
R
--
V
-
Y
G
---
D
I
-
I
H
-
T
------
P
A
K
--------
D
R
R
A
L
V
L
K
-
Q
P
I
G
V
A
A
V
I
T
P
W
N
F
P
--
S
A
M
I
T
R
K
V
G
A
A
L
A
A
G
C
T
V
V
V
K
P
A
E
D
T
P
F
S
A
L
A
L
-
A
E
L
A
----
S
Q
A
G
I
P
S
G
V
Y
N
V
I
P
C
S
R
KN
A
K
E
V
G
E
A
I
C
T
D
P
L
V
S
K
I
S
F
T
G
S
T
T
T
G
K
-----
I
L
----
L
H
H
A
A
--
N
----------
S
V
K
------
R
V
S
M
E
L
G
G
L
A
P
F
I
V
F
D
S
A
N
V
D
Q
A
--
V
A
G
A
M
A
S
K
F
R
N
T
G
Q
T
C
V
C
S
N
Q
F
L
V
Q
R
G
-
I
H
D
A
F
V
K
A
F
A
E
A
M
---------------
K
K
NLRVGNGFEEGTT
Q
G
P
----------------
L
I
N
E
K
--------------
A
V
E
K
V
E
K
Q
V
N
D
A
V
S
K
G
A
T
V
V
-
T
G
G
K
R
H
---
Q
L
G
K
N
F
F
E
P
T
----------
L
L
---
C
-
N
V
T
Q
D
M
-
L
C
T
------------
H
E
E
T
F
G
-
P
L
A
P
V
I
K
F
D
--
T
E
E
E
A
I
A
I
A
N
A
----
A
D
V
G
L
A
G
Y
F
Y
S
Q
---
D
---
P
A
Q
I
W
R
V
A
--
E
Q
L
E
V
G
M
V
G
V
N
E
G
L
I
S
---------
S
--
V
E
C
P
F
G
G
V
K
Q
S
G
L
G
R
E
-
G
S
-
K
Y
G
I
D
E
Y
L
E
L
K
Y
V
C
Y
G
--------------------------------------