@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1207: (2016-03-22 )
LLKTEHISFQYEDGKQALTDVSIDLEKGNIIGLIGANGSGKSTLFMQLLGINKPSDGTVYFEGKPLAYTKKALFALRKKVSIVFQDPDQQIFYSNVRDDVAFALRNLGVSESEVEARVTKVLDIVGAKDFQHKPVQYLSYGQKKRVAIAGALVLDTDWLLLDEPTAGLDPIGKKIMMEIIERLASQGKKILISSHDIDLIYEICDYVYMLKDGSVLTDGETSSVFLEKSNIELAGLVQPWLIKLHQQAGYPLFKKEADFFAHTGKVTN
Atome Classification :
(23 SA)
-.........10-..---.---.---.----...20........30........40........50........60.....-.-..70----------.-......-..80........90......--..100....-...110.......120....-..--.130........140.......150.......160.......170-.......180...-.-...190..-......200.......210.......220.......230.......-----------------------240...---....250.......260......-----------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-LLKT
E
H
I
S
F
Q
Y-ED---G---K---
Q
----
A
L
T
D
V
S
I
D
LEKG
N
I
I
G
L
IGANGSG
K
S
T
L
F
M
Q
L
LGINKPSD
G
T
V
Y
FEGKP
L
-
A
-
Y
T
K
-----------
K
-
A
L
F
A
L
R
-
K
K
V
S
I
V
F
QDPD
Q
Q
I
F
Y
S
N
V
R
--
D
D
V
A
F
A
L
R
N-LGV
S
E
S
E
V
E
A
R
V
T
K
V
L
D
I
VG-AK--DFQ-HKP
V
Q
Y
L
SYGQK
K
R
V
A
I
A
G
A
L
V
LDT
D
W
L
L
LDEPTAGL
D
P
I
G
-
K
K
I
M
M
E
I
I
E
R
L
A
S-Q-G
K
K
I
-
L
I
S-SH
D
I
D
L
I
Y
E
I
C
D
Y
V
Y
M
LKDG
S
V
LTDGET
S
S
V
F
L
EKSN
I
E
L
AG
L
V
Q
P
-----------------------
W
L
I
K
L
H
---QQAGYP
L
F
KKEA
D
F
FAHTGKVTN-----------------------------------------
39
Fugue
86.66
30%
-106
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
H
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
---
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
-
L
S
E
-----------
S
-
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
-
L
S
S
R
T
V
F
--
G
N
V
A
L
P
L
E
L
-
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
-
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLDIPEDYQERLQAEPFTDCV
P
M
L
R
L
E
FTG
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
AQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
2
PsiBlast_PDB
86.14
39%
-108
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-258]
--
I
K
V
E
N
V
S
F
I
Y
-
N
E
---
G
---
T
---
P
YATV
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
-
T
-
D
K
K
-----------
V
-
S
L
K
D
I
R
-
K
Q
V
G
L
V
F
Q
Y
P
E
Y
Q
L
F
E
E
T
V
F
--
K
D
I
A
F
G
P
S
N
-
L
G
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
--
E
L
A
-
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
-
K
Q
E
I
L
N
K
I
K
E
I
H
D
-
K
-
Y
K
M
I
T
I
L
V
-
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
G
L
S
V
P
-----------------------
Q
I
T
S
L
A
---
R
E
--------------------------------------------------------------
57
HHSearch
85.85
41%
-116
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[7-254]
-
I
L
K
V
E
E
L
N
Y
N
Y
-
S
D
---
G
---
T
---
H
----
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
-
D
-
Y
S
R
-----------
K
-
G
I
M
K
L
R
-
E
S
I
G
I
V
F
Q
D
P
D
N
Q
L
F
S
A
S
V
Y
--
Q
D
V
S
F
G
A
V
N
-
M
K
L
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
G
-
I
E
--
H
L
K
-
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
-
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
-
G
I
T
I
-
I
I
A
-
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
K
V
N
L
R
L
P
-----------------------
R
I
G
H
L
M
---
E
I
--------------------------------------------------------------
21
PsiBlast_CBE
85.16
39%
-107
- C1 -
4MKI
4
ECFA2_CALS4
A:
[7-258]
--
I
K
V
E
N
V
S
F
I
Y
-
N
E
---
G
---
T
---
P
YATV
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
-
T
-
D
K
K
-----------
V
-
S
L
K
D
I
R
-
K
Q
V
G
L
V
F
Q
Y
P
E
Y
Q
L
F
E
E
T
V
F
--
K
D
I
A
F
G
P
S
N
-
L
G
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
--
E
L
A
-
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
-
K
Q
E
I
L
N
K
I
K
E
I
H
D
-
K
-
Y
K
M
I
T
I
L
V
-
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
G
L
S
V
P
-----------------------
Q
I
T
S
L
A
---
R
E
--------------------------------------------------------------
1
PsiBlast_PDB
84.76
42%
-113
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[7-248]
-
I
L
K
V
E
E
L
N
Y
N
Y
-
S
D
---
G
---
T
---
H
----
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
-
D
-
Y
S
R
-----------
K
-
G
I
M
K
L
R
-
E
S
I
G
I
V
F
Q
D
P
D
N
Q
L
F
S
A
S
V
Y
--
Q
D
V
S
F
G
A
V
N
-
M
K
L
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
G
-
I
E
--
H
L
K
-
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
-
L
-
G
I
T
I
-
I
I
A
-
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
K
V
N
L
R
L
P
-----------------------
R
I
-----------------------------------------------------------------------
29
PsiBlast_CBE
80.88
32%
-111
- C1 -
3TUI
1
METN_ECOLI
H:
[24-252]
-
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
-----------
S
-
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
-
L
S
S
R
T
V
F
--
G
N
V
A
L
P
L
E
L
-
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
-
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
--------------------------------------------------------------------------------------------------------------
56
HHSearch
80.70
33%
-100
* C1 *
3TUI
1
METN_ECOLI
C:
[24-255]
-
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
GTR
T
---
I
---
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
-
T
L
S
-----------
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
-
L
S
S
R
T
V
F
--
G
N
V
A
L
P
L
E
L
-
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
-
G
L
T
I
-
L
L
I
-
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
-----------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
79.99
32%
-113
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-252]
-
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
-----------
S
-
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
-
L
S
S
R
T
V
F
--
G
N
V
A
L
P
L
E
L
-
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
-
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
--------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
79.85
32%
-114
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-252]
-
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
-----------
S
-
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
-
L
S
S
R
T
V
F
--
G
N
V
A
L
P
L
E
L
-
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
-
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
--------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.28
32%
-109
- C1 -
3TUI
1
METN_ECOLI
C:
[24-252]
-
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
-----------
S
-
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
-
L
S
S
R
T
V
F
--
G
N
V
A
L
P
L
E
L
-
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
-
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
--------------------------------------------------------------------------------------------------------------
67
HHSearch
79.04
31%
-109
- C1 -
1B0U
4
HISP_SALTY
A:
[7-245]
--
L
H
V
I
D
L
H
K
R
Y
-
G
G
-------
H
---
E
----
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
-
N
-
L
V
R
D
KDGQLKVAD
K
N
-
Q
L
R
L
L
R
-
T
R
L
T
M
V
F
Q
H
F
N
L
-
W
S
H
M
T
V
L
--
E
N
V
M
E
A
P
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
-
I
D
--
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
-
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
-
G
K
T
M
-
V
V
V
-
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
----------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
78.89
34%
-104
- C1 -
4HLU
3
ECFA1_THEMA
C:
[12-247]
--
I
E
L
N
S
V
S
F
R
Y
--
N
---
G
---
D
---
Y
----
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
A
-
G
E
I
F
L
D
G
S
P
------------------
A
-
D
P
F
L
L
R
-
K
N
V
G
Y
V
F
Q
N
P
S
S
Q
I
I
G
A
T
V
E
--
E
D
V
A
F
S
L
E
I
-
M
G
L
D
E
S
E
M
R
K
R
I
K
K
V
L
E
L
V
G
-
L
S
--
G
L
A
-
A
A
D
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
-
Q
R
E
I
F
Q
V
L
E
S
L
K
N
-
E
-
G
K
G
I
-
I
L
V
-
T
H
E
L
E
Y
L
D
D
M
-
D
F
I
L
H
I
S
N
G
T
I
D
F
C
G
S
W
E
E
-
F
V
E
R
---
E
F
D
D
V
E
I
P
-----------------------
F
K
W
K
L
W
---
K
K
C
G
------------------------------------------------------------
30
PsiBlast_CBE
78.49
32%
-110
- C1 -
3TUI
1
METN_ECOLI
G:
[24-252]
-
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
-----------
S
-
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
-
L
S
S
R
T
V
F
--
G
N
V
A
L
P
L
E
L
-
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
-
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
--------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.33
32%
-108
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-252]
-
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
-----------
S
-
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
-
L
S
S
R
T
V
F
--
G
N
V
A
L
P
L
E
L
-
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
-
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
--------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.28
31%
-105
- C1 -
1OXV
7
?
A:
[6-241]
----
V
K
N
V
S
K
V
F
-
K
K
---
G
---
K
---
V
V---
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
-
A
-
S
N
G
-----------
K
-
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
---
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
T
N
-
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
-
I
H
--
H
V
L
-
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
-
R
D
S
A
R
A
L
V
K
E
V
Q
S
-
R
L
G
V
T
L
-
L
V
V
-
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
--------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.10
31%
-105
- C1 -
1OXS
19
?
C:
[6-241]
----
V
K
N
V
S
K
V
F
-
K
K
---
G
---
K
---
V
V---
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
-
A
-
S
N
G
-----------
K
-
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
---
T
W
A
L
Y
P
N
L
T
AF
E
N
I
A
F
P
L
T
N
-
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
-
I
H
--
H
V
L
-
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
-
R
D
S
A
R
A
L
V
K
E
V
Q
S
-
R
L
G
V
T
L
-
L
V
V
-
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
--------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
76.80
32%
-111
- C1 -
3TUI
1
METN_ECOLI
D:
[24-252]
-
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
---
T
RTI
Q
----
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-
T
T
L
S
E
-----------
S
-
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
-
L
S
S
R
T
V
F
--
G
N
V
A
L
P
L
E
L
-
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
-
L
G
--
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
-
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
-
L
L
I
-
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
--------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.77
35%
-108
- C1 -
4HUQ
-
ECFA1_LACBA
B:
[5-247]
-
I
I
S
V
D
H
L
T
Y
Q
Y
D
E
N
---
Q
---
A
---
P
----
A
L
T
D
V
S
F
T
V
H
A
G
E
W
L
A
I
V
G
H
N
G
S
G
K
S
T
L
A
K
S
L
D
G
L
L
P
F
T
Q
G
S
V
T
V
G
G
--
I
-
T
-
L
T
P
-----------
E
-
T
V
W
Q
V
R
-
E
Q
I
G
M
I
F
Q
N
P
D
N
Q
F
V
G
A
T
V
E
--
D
D
V
A
F
G
L
E
N
-
R
Q
I
S
R
D
E
M
V
P
R
V
Q
A
A
L
A
Q
V
G
-
M
T
--
S
F
A
-
Q
R
E
P
S
S
L
S
G
G
Q
K
Q
R
V
A
L
A
G
I
V
A
I
A
P
K
I
L
I
L
D
E
A
T
S
M
L
D
P
Q
G
-
R
I
E
M
L
A
I
V
R
Q
L
R
Q
-
Q
-
Q
N
L
T
-
V
I
S
I
T
H
D
I
D
E
A
A
S
-
A
D
R
V
L
V
I
D
D
G
R
L
V
D
E
A
V
P
S
Q
I
F
E
R
G
T
Q
L
V
E
M
G
L
D
L
P
-----------------------
F
T
E
K
L
--------------------------------------------------------------------
4
PsiBlast_PDB
76.74
35%
-97
- C1 -
4HZU
-
ECFA1_LACBA
A:
[5-247]
-
I
I
S
V
D
H
L
T
Y
Q
Y
------
Q
---
A
---
P
----
A
L
T
D
V
S
F
T
V
H
A
G
E
W
L
A
I
V
G
H
N
G
S
G
K
S
T
L
A
K
S
L
D
G
L
L
P
F
T
Q
G
S
V
T
V
G
G
--
I
-
T
-
L
T
P
-----------
E
-
T
V
W
Q
V
R
-
E
Q
I
G
M
I
F
Q
N
P
D
N
Q
F
V
G
A
T
V
E
--
D
D
V
A
F
G
L
E
N
-
R
Q
I
S
R
D
E
M
V
P
R
V
Q
A
A
L
A
Q
V
G
-
M
T
--
S
F
A
-
Q
R
E
P
S
S
L
S
G
G
Q
K
Q
R
V
A
L
A
G
I
V
A
I
A
P
K
I
L
I
L
D
E
A
T
S
M
L
D
P
Q
G
-
R
I
E
M
L
A
I
V
R
Q
L
R
Q
-
Q
-
Q
N
L
T
-
V
I
S
I
T
H
D
I
D
E
A
A
S
-
A
D
R
V
L
V
I
D
D
G
R
L
V
D
E
A
V
P
S
Q
I
F
E
R
G
T
Q
L
V
E
M
G
L
D
L
P
-----------------------
F
T
E
K
L
--------------------------------------------------------------------
14
PsiBlast_PDB
76.68
30%
-107
- C1 -
1OXX
22
?
K:
[6-241]
----
V
K
N
V
S
K
V
F
-
K
K
---
G
---
K
---
V
V---
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
-
A
-
S
N
G
-----------
K
-
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
---
T
W
A
L
Y
P
N
L
T
AF
E
N
I
A
F
P
L
T
N
-
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
-
I
H
--
H
V
L
-
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
-
R
D
S
A
R
A
L
V
K
E
V
Q
S
-
R
L
G
V
T
L
-
L
V
V
-
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
--------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
76.25
37%
-103
- C1 -
4HLU
3
ECFA2_THEMA
B:
[22-230]
----------------------
K
---
K
----
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
-------
R
-----------
K
-
K
G
Y
E
I
R
-
R
N
I
G
I
A
F
Q
Y
P
E
D
Q
F
F
A
E
R
V
F
--
D
E
V
A
F
A
V
K
N
-
F
Y
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
G
-
L
D
FD
S
F
K
-
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
-
K
T
D
L
L
R
I
V
E
K
W
K
T
-
L
-
G
K
T
V
-
I
L
I
-
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
-
T
R
M
E
F
L
E
K
-----------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
76.09
37%
-103
- C1 -
4HLU
2
ECFA2_THEMA
A:
[22-230]
----------------------
K
---
K
----
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
-------
R
-----------
K
-
K
G
Y
E
I
R
-
R
N
I
G
I
A
F
Q
Y
P
E
D
Q
F
F
A
E
R
V
F
--
D
E
V
A
F
A
V
K
N
-
F
Y
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
G
-
L
D
FD
S
F
K
-
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
-
K
T
D
L
L
R
I
V
E
K
W
K
T
-
L
-
G
K
T
V
-
I
L
I
-
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
-
T
R
M
E
F
L
E
K
-----------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
69.60
37%
-112
- C1 -
4ZIR
5
ECFA2_THEMA
A:
[21-229]
----------------------
K
---
K
----
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
---------------------
K
G
Y
E
I
R
-
R
N
I
G
I
A
F
Q
Y
P
E
D
Q
F
F
A
E
R
V
F
--
D
E
V
A
F
A
V
K
N
-
F
Y
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
G
-
L
D
FD
S
F
K
-
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
-
K
T
D
L
L
R
I
V
E
K
W
K
T
-
L
-
G
K
T
V
-
I
L
I
-
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
-
T
R
M
E
F
L
E
K
-----------------------------------------------------------------------------------------------------------