@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1231: (2016-03-22 )
MATNKKEIIRLLEEIATYMELKGENSFKISAFRKAAQAIELDSRSLSEIDDFTKISGIGKTTGEIIQRYLDSGECPELEELKKEVPAGLVPLLDVPGLGGKKLSRLYHELGVVDKDTLLQEAENGHIEALKGFGKKSAEKMAEAVREMGERPDRYPLNDVLPIIQKVEAYLAEIAPIETFAQAGSLRRLRETVKDLDYVIATEKPEDVQKALLAFPLITDVIGAGETKVSAVLEDNITISVDFRLVEKKAFATTLHHFTGSKDHNIKMRQLAKQSNEKISEYGVEQEDGTVRHFESEKTFFEHFKIPFLPPEVRRDGTEIERVTKDTKFLELSDIRGDLHMHTTWSDGAYAIPEMIEACIAKGYEYMVITDHGKFLRVANGLDEKRLLEQQAEIKKIAAKYPEIDVYSGVEMDILADGSLDFDDETLKQLDFVIASIHSSFQQSEEEIMKRLKTACENPYVRLIAHPTGRIVVKRKPYHVNMKELIQLAKSTGTALELNANPQRLDLNREHLEMAHAAGVPIAINTDAHDTKHLDFMSIGVRAATKAWLGKSAILNTKTAAEFKQFLQNK
Atome Classification :
(20 SA)
.........10........20........30........-40........--50----.-----........60........70........80........90...-.....100.......110.......120......--.130.......140.......150.......160.......-170.......180.......190.......200------.....-------.---...210.......220...-----....230..--------...----..240.......250....---...260.......270.......280-----......-----------.290.......300.......310...-....320-.....--...330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.....-.-.510.......520.......530.......540.......550.......560.......570---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAT
N
K
K
E
I
I
R
L
L
E
E
I
A
T
Y
M
E
LKGENSF
K
I
S
A
F
R
K
A
A
Q
A
I-ELDSR
S
L
S
E
I
--
D
-----
D
-----
F
T
KISGIGK
T
T
G
E
I
I
Q
R
Y
LDSGECP
E
L
E
E
L
K
K
EVPAGLVPLLD-VPGL
G
G
K
K
L
S
R
L
Y
H
E
LGVV
D
K
D
T
L
L
Q
EAENG
H
I
E
--
A
L
K
GF
G
K
K
S
A
E
K
M
A
E
A
V
R
E
MGERPDRYP
L
N
D
V
L
P
I
I
Q
K
V
E
A
-
Y
L
A
E
I
A
P
I
E
T
F
A
QA
G
S
L
R
R
L
R
E
T
V
K
D
L
D
Y
V
I--------ATE
K
P
-------
E
---
D
V
Q
K
A
L
L
A
F
P
L
I
T
D
V
IGAG-----ET
K
V
S
A
V
LE--------D
N
I
----
T
I
S
V
D
F
R
L
V
E
K
K
A
F
A
T
T
L
H
---
H
FTGSKDH
N
I
K
M
R
Q
L
A
K
QSN
E
K
I
S
EY-----GVEQED-----------G
T
V
R
H
FES
E
K
T
F
F
E
HFKIPFL
P
P
E
VRR-DG
T
E
I
E
--
R
V
TKD--T
K
F
L
E
L
SDIRG
D
L
H
M
H
T
TWSDG
A
Y
A
I
P
E
M
I
E
A
C
I
AKG
Y
E
Y
M
V
ITDHG
K
F
L
R
V
ANGL
D
E
K
R
L
L
E
Q
Q
A
E
I
K
K
I
A
A
KYPE
I
D
V
YSGV
E
M
D
I
L
ADGSLDF
D
D
E
T
L
K
Q
L
D
F
V
I
A
S
I
H
S
S
F
Q
Q
S
E
E
E
I
M
K
R
L
K
T
A
CENP
Y
V
R
L
I
AHPT
G
R
I
V
V
KRKPYHV
N
M
K
E
L
I
Q
L
A
K
STG
T
A
L
E
LNANPQRLDL-
N
-
R
E
H
L
E
M
A
HAAGV
P
I
A
I
NTDAHDTKH
L
D
F
M
S
I
G
V
R
A
A
T
K
A
WLGKSAILN
T
K
T
A
A
E
F
K
Q
F
LQNK-----
21
PsiBlast_CBE
95.23
32%
-78
- C2 -
3AUO
4
?
B:
[2-572]
---
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
Y
D
L
D
T
-
P
I
E
E
I
--
A
-----
E
KGKEA
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
S
R
K
V
P
R
G
V
L
E
V
M
E
-
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
L
K
A
A
L
D
R
G
D
L
T
--
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
-
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
---
R
A
V
E
G
F
V
R
L
P
Q
V
K
E
V
Y
A
K
G
-----
K
E
R
A
T
V
F
L
K
--------
N
G
L
------
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
---
Y
L
T
G
S
K
A
H
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
-----------
K
R
I
A
G
-
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
-
D
Q
G
E
V
E
--
A
A
L
E
G
RL
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
-
D
D
L
A
R
M
A
Y
G
M
G
L
W
I
S
L
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
A
R
-----
1
PsiBlast_PDB
95.16
32%
-82
- C2 -
3AU2
9
?
A:
[2-572]
---
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
Y
D
L
D
T
-
P
I
E
E
I
--
A
-----
E
K
G
K
E
A
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
S
R
K
V
P
R
G
V
L
E
V
M
E
-
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
L
K
A
A
L
D
R
G
D
L
T
--
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
-
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
---
R
A
V
E
G
F
V
R
L
P
Q
V
K
E
V
Y
A
K
G
-----
K
E
R
A
T
V
F
L
K
--------
N
G
L
------
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
---
Y
L
T
G
S
K
A
H
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
-----------
K
R
I
A
G
-
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
-
D
Q
G
E
V
E
--
A
A
L
E
G
RL
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
-
D
D
L
A
R
M
A
Y
G
M
G
L
W
I
S
L
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
A
R
-----
23
HHSearch
94.86
33%
-80
- C2 -
3B0X
8
?
A:
[2-571]
---
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
-
Y
D
L
D
T
P
I
E
E
I
--
A
E
K
G
K
E
A
-----
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
S
R
K
V
P
R
G
V
L
E
V
M
E
-
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
L
K
A
A
L
D
R
G
D
L
T
--
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
-
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
---
R
A
V
E
G
F
V
R
L
P
Q
V
K
E
V
Y
A
K
G
-----
K
E
R
A
T
V
F
----------
L
K
N
----
G
L
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
---
Y
L
T
G
S
A
A
H
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
------------
K
R
I
A
G
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
-
D
Q
G
E
V
E
--
A
A
L
E
G
RL
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
-
D
D
L
A
R
M
A
Y
G
M
G
L
W
I
S
L
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
A
------
4
PsiBlast_PDB
94.81
32%
-82
- C2 -
3B0Y
7
?
A:
[2-572]
---
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
Y
D
L
D
T
-
P
I
E
E
I
--
A
-----
E
K
G
K
E
A
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
S
R
K
V
P
R
G
V
L
E
V
M
E
-
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
L
K
A
A
L
D
R
G
D
L
T
--
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
-
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
---
R
A
V
E
G
F
V
R
L
P
Q
V
K
E
V
Y
A
K
G
-----
K
E
R
A
T
V
F
L
K
--------
N
G
L
------
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
---
Y
L
T
G
S
D
A
H
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
-----------
K
R
I
A
G
-
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
-
D
Q
G
E
V
E
--
A
A
L
E
G
RL
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
-
D
D
L
A
R
M
A
Y
G
M
G
L
W
I
S
L
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
A
R
-----
3
PsiBlast_PDB
94.65
32%
-83
- C2 -
3B0X
8
?
A:
[2-572]
---
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
Y
D
L
D
T
-
P
I
E
E
I
--
A
-----
E
K
G
K
E
A
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
S
R
K
V
P
R
G
V
L
E
V
M
E
-
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
L
K
A
A
L
D
R
G
D
L
T
--
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
-
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
---
R
A
V
E
G
F
V
R
L
P
Q
V
K
E
V
Y
A
K
G
-----
K
E
R
A
T
V
F
L
K
--------
N
G
L
------
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
---
Y
L
T
G
S
A
A
H
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
-----------
K
R
I
A
G
-
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
-
D
Q
G
E
V
E
--
A
A
L
E
G
RL
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
-
D
D
L
A
R
M
A
Y
G
M
G
L
W
I
S
L
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
A
R
-----
2
PsiBlast_PDB
93.72
32%
-73
- C2 -
3AUO
4
?
A:
[2-572]
---
R
N
Q
E
L
A
R
I
F
E
E
I
G
L
M
S
E
F
L
G
D
N
P
F
R
V
R
A
Y
H
Q
A
A
R
T
L
Y
D
L
D
T
-
P
I
E
E
I
--
A
-----
E
KG
K
E
A
L
M
E
L
P
G
V
G
P
D
L
A
E
K
I
L
E
F
L
R
T
G
K
V
R
K
H
E
E
L
S
R
K
V
P
R
G
V
L
E
V
M
E
-
V
P
G
V
G
P
K
T
A
R
L
L
Y
E
G
L
G
I
D
S
L
E
K
L
K
A
A
L
D
R
G
D
L
T
--
R
L
K
G
F
G
P
K
R
A
E
R
I
R
E
G
L
A
L
A
Q
A
A
G
K
R
R
P
L
G
A
V
L
S
L
A
R
S
L
L
E
-
A
I
R
A
L
P
G
V
E
R
A
E
L
C
G
S
A
R
R
Y
K
D
T
V
G
D
L
D
F
L
V
--------
A
S
R
E
G
-------
E
---
R
A
V
E
G
F
V
R
L
P
Q
V
K
E
V
Y
A
K
G
-----
K
E
R
A
T
V
F
L
K
--------
N
G
L
------
Q
V
D
L
R
V
V
P
P
E
S
Y
G
A
G
L
Q
---
Y
L
T
G
S
K
A
H
S
I
R
L
R
A
L
A
Q
E
K
G
L
K
L
S
E
Y
-----
G
V
F
R
G
E
-----------
K
R
I
A
G
-
E
T
E
E
E
V
Y
A
A
L
G
L
P
W
I
P
P
P
L
R
E
-
D
Q
G
E
V
E
--
A
A
L
E
G
RL
P
K
L
L
E
L
P
Q
V
K
G
D
L
Q
V
H
S
T
Y
S
D
G
Q
N
T
L
E
E
L
W
E
A
A
K
T
M
G
Y
R
Y
L
A
V
T
D
H
S
P
A
V
R
V
A
G
G
P
S
P
E
E
A
L
K
R
V
G
E
I
R
R
F
N
E
T
H
G
P
P
Y
L
L
A
G
A
E
V
D
I
H
P
D
G
T
L
D
Y
P
D
W
V
L
R
E
L
D
L
V
L
V
S
V
H
S
R
F
N
L
P
K
A
D
Q
T
K
R
L
L
K
A
L
E
N
P
F
V
H
V
L
A
H
P
T
A
R
L
L
G
R
R
A
P
I
E
A
D
W
E
A
V
F
Q
K
A
K
E
K
G
V
A
V
E
I
D
G
Y
Y
D
R
M
D
L
-
P
-
D
D
L
A
R
M
A
Y
G
M
G
L
W
I
S
L
S
T
D
A
H
Q
T
D
H
L
R
F
M
E
L
A
V
G
T
A
Q
R
A
W
I
G
P
E
R
V
L
N
T
L
D
Y
E
D
L
L
S
W
L
K
A
R
-----
22
PsiBlast_CBE
83.94
31%
-61
- C2 -
2W9M
4
?
B:
[7-559]
-
A
P
S
R
H
R
L
V
H
A
L
E
R
T
A
D
L
L
D
I
L
G
G
E
D
F
K
S
R
A
Y
R
S
A
A
R
S
L
-
E
E
L
N
E
E
T
P
E
L
L
A
R
-----
E
-----
F
T
G
I
P
K
V
G
K
G
I
A
A
E
L
S
D
F
A
R
S
G
T
F
A
P
L
E
A
A
A
G
Q
L
P
P
G
L
L
D
L
L
G
-
V
R
G
L
G
P
K
K
I
R
S
L
W
L
A
-
G
I
D
S
L
E
R
L
R
E
A
A
E
S
G
E
L
A
--
G
L
K
G
F
G
A
K
S
A
A
T
I
L
E
N
V
V
F
L
F
E
A
R
Q
R
Q
S
L
R
A
G
L
A
V
A
E
E
L
A
G
-
A
L
T
D
L
S
P
----
A
P
A
G
D
V
R
R
G
L
E
T
V
R
A
A
E
L
T
V
---------
T
G
T
P
-------
D
---
D
V
L
A
R
L
P
E
L
T
V
Q
G
D
G
V
L
S
G
-----
D
Y
---------------
E
G
V
----
P
V
E
I
A
C
A
P
A
E
A
R
G
A
L
D
L
L
R
S
G
E
H
F
A
G
Q
V
Q
A
A
A
Q
A
R
G
F
------
T
L
T
A
G
-----
G
L
S
R
G
D
------------
E
V
L
P
T
P
T
E
A
V
V
F
H
A
L
D
L
P
F
R
P
A
E
Y
R
E
P
E
H
D
D
L
W
--
Q
T
L
P
D
P-
A
E
L
V
T
V
G
D
L
R
G
M
I
H
T
H
S
T
W
S
D
G
G
A
S
I
R
E
M
A
E
A
T
L
T
L
G
H
E
F
L
G
T
A
D
H
S
R
A
A
Y
Y
A
N
G
L
T
I
E
R
L
R
E
Q
L
K
E
I
R
E
L
--
Q
R
A
G
L
P
I
V
A
G
S
E
V
D
I
L
D
D
G
S
L
D
F
P
D
D
V
L
G
E
L
D
Y
V
V
V
S
V
H
S
N
F
T
L
D
A
A
R
Q
T
E
R
L
I
R
A
V
S
H
P
L
V
T
V
L
G
H
A
T
G
R
L
L
L
R
R
P
G
Y
A
L
D
L
D
A
V
L
G
A
C
E
A
N
G
T
V
V
E
I
N
A
N
A
A
R
L
D
L
-
D
W
R
E
A
L
R
W
R
E
R
--
L
K
F
A
I
N
T
D
A
H
V
P
G
G
L
R
D
A
R
Y
G
V
M
Q
A
R
K
A
G
L
T
P
A
H
V
V
N
S
L
G
R
A
E
F
L
D
F
V
A
R
Q
-----
5
PsiBlast_PDB
82.16
31%
-63
- C2 -
2W9M
4
?
A:
[8-559]
--
P
S
R
H
R
L
V
H
A
L
E
R
T
A
D
L
L
D
I
L
---
D
F
K
S
R
A
Y
R
S
A
A
R
S
L
-
E
E
L
N
--------------------
F
T
G
I
P
K
V
G
K
G
I
A
A
E
L
S
D
F
A
R
S
G
T
F
A
P
L
E
A
A
A
G
Q
L
P
P
G
L
L
D
L
L
G
-
V
R
G
L
G
P
K
K
I
R
S
L
W
L
A
-
G
I
D
S
L
E
R
L
R
E
A
A
E
S
G
E
L
A
--
G
L
K
G
F
G
A
K
S
A
A
T
I
L
E
N
V
V
F
L
F
E
A
R
Q
R
Q
S
L
R
A
G
L
A
V
A
E
E
L
A
G
-
A
L
T
D
L
S
P
----
A
P
A
G
D
V
R
R
G
L
E
T
V
R
A
A
E
L
T
V
---------
T
G
T
P
-------
D
---
D
V
L
A
R
L
P
E
L
T
V
Q
---
V
L
S
G
-----
D
Y
---------------
E
G
V
----
P
V
E
I
A
C
A
P
A
E
A
R
G
A
L
D
L
L
R
S
G
E
H
F
A
G
Q
V
Q
A
A
A
Q
A
R
G
F
------
T
L
T
A
G
-----
G
L
S
R
G
D
------------
E
V
L
P
T
P
T
E
A
V
V
F
H
A
L
D
L
P
F
R
P
A
E
Y
R
E
P
E
H
D
D
L
W
--
Q
T
L
P
D
P-
A
E
L
V
T
V
G
D
L
R
G
M
I
H
T
H
S
T
W
S
D
G
G
A
S
I
R
E
M
A
E
A
T
L
T
L
G
H
E
F
L
G
T
A
D
H
S
R
A
A
Y
Y
A
N
G
L
T
I
E
R
L
R
E
Q
L
K
E
I
R
E
L
--
Q
R
A
G
L
P
I
V
A
G
S
E
V
D
I
L
D
D
G
S
L
D
F
P
D
D
V
L
G
E
L
D
Y
V
V
V
S
V
H
S
N
F
T
L
D
A
A
R
Q
T
E
R
L
I
R
A
V
S
H
P
L
V
T
V
L
G
H
A
T
G
R
L
L
L
R
R
P
G
Y
A
L
D
L
D
A
V
L
G
A
C
E
A
N
G
T
V
V
E
I
N
A
N
A
A
R
L
D
L
-
D
W
R
E
A
L
R
W
R
E
R
--
L
K
F
A
I
N
T
D
A
H
V
P
G
G
L
R
D
A
R
Y
G
V
M
Q
A
R
K
A
G
L
T
P
A
H
V
V
N
S
L
G
R
A
E
F
L
D
F
V
A
R
Q
-----
45
Fugue
81.28
30%
-57
- C2 -
2W9M
4
?
A:
[8-564]
--
P
S
R
H
R
L
V
H
A
L
E
R
T
A
D
L
L
D
I
L
D
---
F
K
S
R
A
Y
R
S
A
A
R
S
L
-
E
E
L
---------------
N
-----
F
T
G
I
P
K
V
G
K
G
I
A
A
E
L
S
D
F
A
R
S
G
T
F
A
P
L
E
A
A
A
G
Q
L
P
P
G
L
L
D
L
L
G
-
V
R
G
L
G
P
K
K
I
R
S
L
W
L
A
-
G
I
D
S
L
E
R
L
R
E
A
A
E
S
G
E
L
A
--
G
L
K
G
F
G
A
K
S
A
A
T
I
L
E
N
V
V
F
L
F
E
A
R
Q
R
Q
S
L
R
A
G
L
A
V
A
E
E
L
A
G
-
A
L
T
D
L
S
P
----
A
P
A
G
D
V
R
R
G
L
E
T
V
R
A
A
E
L
T
V
--------
T
G
T
P
D
-------
D
---
V
L
A
R
----
L
P
E
L
T
V
Q
V
L
S
G
-----
D
Y
E
---------------------
G
V
P
V
E
I
A
C
A
P
A
E
-
A
R
G
A
L
D
---
L
L
R
S
G
E
H
F
A
G
Q
V
Q
A
A
A
Q
A
R
G
F
T
L
T
A
G
-----
G
L
S
R
-
G
-----------
D
E
V
L
P
T
P
T
E
A
V
V
F
H
A
L
D
L
P
F
R
P
A
E
Y
R
E
-
P
E
H
D
D
L
WQ
T
L
P
D
P
--
A
E
L
V
T
V
G
D
L
R
G
M
I
H
T
H
S
T
W
S
D
G
G
A
S
I
R
E
M
A
E
A
T
L
T
L
G
H
E
F
L
G
T
A
D
H
S
R
A
A
Y
Y
A
N
G
L
T
I
E
R
L
R
E
Q
L
K
E
I
R
E
L
Q
R
--
A
G
L
P
I
V
A
G
S
E
V
D
I
L
D
D
G
S
L
D
F
P
D
D
V
L
G
E
L
D
Y
V
V
V
S
V
H
S
N
F
T
L
D
A
A
R
Q
T
E
R
L
I
R
A
V
S
H
P
L
V
T
V
L
G
H
A
T
G
R
L
L
L
R
R
P
G
Y
A
L
D
L
D
A
V
L
G
A
C
E
A
N
G
T
V
V
E
I
N
A
N
A
A
R
L
D
L
-
D
-
W
R
E
A
L
R
W
R
E
-
R
L
K
F
A
I
N
T
D
A
H
V
P
G
G
L
R
D
A
R
Y
G
V
M
Q
A
R
K
A
G
L
T
P
A
H
V
V
N
S
L
G
R
A
E
F
L
D
F
V
A
R
Q
R
A
A
R
G
24
HHSearch
81.13
32%
-62
- C2 -
2W9M
4
?
A:
[8-558]
--
P
S
R
H
R
L
V
H
A
L
E
R
T
A
D
L
L
D
I
L
---
D
F
K
S
R
A
Y
R
S
A
A
R
S
L
-
E
E
L
N
--------------------
F
T
G
I
P
K
V
G
K
G
I
A
A
E
L
S
D
F
A
R
S
G
T
F
A
P
L
E
A
A
A
G
Q
L
P
P
G
L
L
D
L
L
G
-
V
R
G
L
G
P
K
K
I
R
S
L
W
L
-
A
G
I
D
S
L
E
R
L
R
E
A
A
E
S
G
E
L
A
--
G
L
K
G
F
G
A
K
S
A
A
T
I
L
E
N
V
V
F
L
F
E
A
R
Q
R
Q
S
L
R
A
G
L
A
V
A
E
E
L
A
G
-
A
L
----
T
D
L
S
P
A
P
A
G
D
V
R
R
G
L
E
T
V
R
A
A
E
L
T
V
--------
T
G
T
P
--------
D
---
D
V
L
A
R
L
P
E
L
T
V
Q
--------------
V
L
S
G
D
-----------
Y
E
----
G
V
P
V
E
I
A
C
A
P
A
E
A
R
G
A
L
D
L
---
L
R
S
-
G
E
H
F
A
G
Q
V
Q
A
A
A
Q
A
R
G
F
T
L
T
A
G
-----
G
L
S
R
G
D
------------
E
V
L
P
T
P
T
E
A
V
V
F
H
A
L
D
L
P
F
R
P
A
E
Y
R
E
-
P
E
H
D
D
L
--
W
Q
T
L
P
DP
A
E
L
V
T
V
G
D
L
R
G
M
I
H
T
H
S
T
W
S
D
G
G
A
S
I
R
E
M
A
E
A
T
L
T
L
G
H
E
F
L
G
T
A
D
H
S
R
A
A
Y
Y
A
N
G
L
T
I
E
R
L
R
E
Q
L
K
E
I
R
E
L
Q
--
R
A
G
L
P
I
V
A
G
S
E
V
D
I
L
D
D
G
S
L
D
F
P
D
D
V
L
G
E
L
D
Y
V
V
V
S
V
H
S
N
F
T
L
D
A
A
R
Q
T
E
R
L
I
R
A
V
S
H
P
L
V
T
V
L
G
H
A
T
G
R
L
L
L
R
R
P
G
Y
A
L
D
L
D
A
V
L
G
A
C
E
A
N
G
T
V
V
E
I
N
A
N
A
A
R
L
D
L
D
W
-
R
E
A
L
R
--
W
R
E
R
L
K
F
A
I
N
T
D
A
H
V
P
G
G
L
R
D
A
R
Y
G
V
M
Q
A
R
K
A
G
L
T
P
A
H
V
V
N
S
L
G
R
A
E
F
L
D
F
V
A
R
------
16
PsiBlast_PDB
55.20
24%
-72
- C2 -
4M2Y
5
DPOLB_HUMAN
A:
[5-323]
-------
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
-
A
K
Y
P
H
K
I
K
S
G
--
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
R
V
S
G
I
G
P
S
A
A
R
K
F
V
D
E
G
I
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
--------
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
--------
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
-----------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
PSDEK--
E
Y
P
----
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
---
Y
F
T
G
S
D
I
F
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
55.04
24%
-67
- C2 -
4PH5
8
DPOLB_HUMAN
A:
[6-324]
-------
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
-
A
K
Y
P
H
K
I
K
S
G
--
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
R
V
S
G
I
G
P
S
A
A
R
K
F
V
D
E
G
I
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
--------
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
--------
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
T
K
Q
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
SKNDEK
E
Y
P
----
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
---
Y
F
T
G
S
D
I
F
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
54.91
24%
-65
- C2 -
4TUS
9
DPOLB_HUMAN
A:
[6-324]
-------
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
-
A
K
Y
P
H
K
I
K
S
G
--
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
R
V
S
G
I
G
P
S
A
A
R
K
F
V
D
E
G
I
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
--------
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
--------
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
T
K
Q
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
S
KNEK-
E
Y
P
----
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
---
Y
F
T
G
S
D
I
F
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
54.87
24%
-71
- C2 -
4MFF
8
DPOLB_HUMAN
A:
[5-323]
-------
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
-
A
K
Y
P
H
K
I
K
S
G
--
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
R
V
S
G
I
G
P
S
A
A
R
K
F
V
D
E
G
I
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
--------
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
--------
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
---
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
SKD
E
K
-
E
Y
P
----
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
---
Y
F
T
G
S
D
I
F
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
54.82
24%
-70
- C2 -
4P2H
8
DPOLB_HUMAN
A:
[6-324]
-------
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
-
A
K
Y
P
H
K
I
K
S
G
--
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
R
V
S
G
I
G
P
S
A
A
R
K
F
V
D
E
G
I
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
--------
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
--------
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
--
Q
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
SKNDEK
E
Y
P
----
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
---
Y
F
T
G
S
D
I
F
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
54.52
24%
-68
- C2 -
4MF2
5
DPOLB_HUMAN
A:
[5-323]
-------
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
-
A
K
Y
P
H
K
I
K
S
G
--
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
R
V
S
G
I
G
P
S
A
A
R
K
F
V
D
E
G
I
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
--------
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
--------
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE----
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
SKND
E
K
E
Y
P
----
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
---
Y
F
T
G
S
D
I
F
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
54.49
24%
-52
- C2 -
2BCQ
9
DPOLL_HUMAN
A:
[12-335]
---
H
N
L
H
I
T
E
K
L
E
V
L
A
K
A
Y
S
V
Q
G
-
D
K
W
R
A
L
G
Y
A
K
A
I
N
A
L
-
K
S
F
H
K
P
V
T
S
Y
--
Q
-----
E
-----
A
C
S
I
P
G
I
G
K
R
M
A
E
K
I
I
E
I
L
E
S
G
H
L
R
K
L
D
H
I
S
E
S
V
P
-
V
L
E
L
F
S
N
-
I
W
G
A
G
T
K
T
A
Q
M
W
Y
Q
-
Q
G
F
R
S
L
E
D
I
R
S
Q
A
S
---------------
L
T
T
Q
Q
A
I
G
L
K
H
Y
S
D
F
L
E
R
M
P
R
E
E
A
T
E
I
E
Q
T
V
Q
K
-
A
A
Q
A
F
N
S
G
L
L
C
V
A
C
G
S
Y
R
R
G
K
A
T
C
G
D
V
D
V
L
I
--------
T
H
P
D
G
RSHRGI
F
S
---
R
L
L
D
S
L
R
Q
E
G
F
L
T
D
D
L
V
S
Q
EENGQ
Q
Q
K
Y
L
G
V
C
R
--------
L
P
G
P
G
R
R
H
R
R
L
D
I
I
V
V
P
Y
S
E
F
A
C
A
L
L
---
Y
F
T
G
S
A
H
F
N
R
S
M
R
A
L
A
K
T
K
G
M
S
L
S
E
H
-----
A
L
S
T
A
V
V
R
N
THGCKVGP
G
R
V
L
P
T
P
T
E
K
D
V
F
R
L
L
G
L
P
Y
R
E
P
A
E
R
D
-
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
54.32
24%
-64
- C2 -
3GDX
10
DPOLB_HUMAN
A:
[6-324]
-------
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
-
A
K
Y
P
H
K
I
K
S
G
--
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
R
V
S
G
I
G
P
S
A
A
R
K
F
V
D
E
G
I
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
--------
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
--------
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
T
K
Q
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
SKNDEK
E
Y
P
----
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
---
Y
F
T
G
S
D
I
F
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
54.08
24%
-64
- C2 -
4TUQ
8
DPOLB_HUMAN
A:
[6-324]
-------
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
-
A
K
Y
P
H
K
I
K
S
G
--
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
R
V
S
G
I
G
P
S
A
A
R
K
F
V
D
E
G
I
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
--------
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
--------
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
T
K
Q
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
S
K
N
DEK
E
Y
P
----
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
---
Y
F
T
G
S
D
I
F
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
54.03
24%
-64
- C2 -
4PHP
8
DPOLB_HUMAN
A:
[6-324]
-------
I
T
D
M
L
T
E
L
A
N
F
E
K
N
V
S
Q
A
I
H
K
Y
N
A
Y
R
K
A
A
S
V
I
-
A
K
Y
P
H
K
I
K
S
G
--
A
-----
E
-----
A
K
K
L
P
G
V
G
T
K
I
A
E
K
I
D
E
F
L
A
T
G
K
L
R
K
L
E
K
I
R
Q
D
D
T
S
S
S
I
N
F
L
T
R
V
S
G
I
G
P
S
A
A
R
K
F
V
D
E
G
I
K
T
L
E
D
L
R
K
N
E
D
K
L
N
H
H
Q
R
I
G
L
K
Y
F
G
D
F
E
K
R
I
P
R
E
E
M
L
Q
M
Q
D
I
--------
V
L
N
E
V
K
K
V
D
S
E
Y
I
A
T
V
--------
C
G
S
F
R
R
G
A
E
S
S
G
D
M
D
V
L
L
T
H
PSFTSE
S
T
K
Q
P
-------
K
L
L
H
Q
V
V
E
Q
L
Q
K
V
H
F
I
T
D
T
L
S
K
G
-----
E
T
K
F
M
G
V
C
Q
L
P
S
K
N
DEK
E
Y
P
----
H
R
R
I
D
I
R
L
I
P
K
D
Q
Y
Y
C
G
V
L
---
Y
F
T
G
S
D
I
F
N
K
N
M
R
A
H
A
L
E
K
G
F
T
I
N
E
Y
T
I
R
P
L
G
V
T
G
V
A
-----------
G
E
P
L
P
V
D
S
E
K
D
I
F
D
Y
I
Q
W
K
Y
R
E
P
K
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------