@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1276: (2016-03-23 )
MEKSVNVIGAGLAGSEAVWQLVNRGVKVDLYEMRPVKQTPAHHTDKFAELVCTNSLRANGLTNAVGVIKEEMRMLDSIIIEAADKASVPAGGALAVDRHEFSGYITDKVKNHPLVTVHTEEVTTIPEGPTIIATGPLTSPALADEIKQLTGEEYLYFYDAAAPIIEKDSIDMDKVYLKSRYDKGEAAYLNCPMSEEEFNAFYEALVTAETAALKEFEKEVFFEGCMPIEVMAKRGIKTMLFGPLKPVGLEDPKTGKRPYAVLQLRQDDAAGTLYNMVGFQTHLKWGEQKRVFGMIPGLENAEIVRYGVMHRNTFINSPTVLEPTYQLKTRNDLFFAGQMTGVEGYVESAASGLAAGINAANFIQEKELVVFPTETAIGSLAHYITSASKKSFQPMNVNFGLFPELETKIRAKQERNEKLAERALNAIKKVAEEL
Atome Classification :
(20 SA)
..------.......10........20....--....30....--.-...40------........50.----...-....60........70-.-..-.----.-----.----------...--80.-.---.---.-.----------.-----.--------.--90........100.......110-.---------------......----------------------120---------------------.........130......-.140-------------------.........150.......160.......170.......180..-.....190.-.-.....200.......210.--......220.......230.......240.......250.......260.......270.......280..-.....290.......300.......310.......320.......330.......340-..--......350.......360...---....370.-....-...380.......-----------------------.390.......400.....-..410.......420.......430..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME------K
S
V
N
V
I
GAGLA
G
S
E
A
V
W
Q
L
V
NRG--
V
K
V
D
L
Y
E
MRP--V-KQTPA------H
H
T
D
K
F
A
E
L
V
C----TNS-LRANGL
T
N
A
V
G
V
I
K
E
--
E
-
M
R
-
M
----
L
-----
D
----------
S
I
I
--
I
EA-A---D---K-A----------S-----V--------P--AG
G
A
L
A
V
DRHEFS
G
Y
ITDKVKNH-
P
---------------
L
V
T
V
HT----------------------E-----------------------EVTTIPEG
P
T
I
I
A
TGPLT-S
P
---------------------
A
L
A
D
E
I
K
Q
LTGE
E
Y
L
Y
F
YDAAAPIIEKDSI
D
M
D
K
V
Y
L
K
SRYDKG-
E
A
A
Y
LNCPM-
S
-
E
E
E
F
N
A
F
Y
E
A
L
V
T
A
E
T
A
A
L
--
K
E
F
E
K
E
V
F
FEGCM
P
I
E
V
M
A
KRG
I
K
T
MLFGPLKPVGLEDPKTGKR
P
Y
A
V
L
Q
L
RQDDAA
G
T
L
Y
N
M
VG
F
Q
T
H
LK-WGEQ
K
R
V
F
G
MIPGLE
N
A
E
I
V
R
Y
G
V
M
HRNTFINSPTVLEP
T
Y
Q
L
KTRN
D
L
F
F
AGQMTG--
V
E
--
G
Y
V
E
S
A
A
S
G
L
A
A
G
I
N
A
A
N
F
IQE---K
E
L
V
V
F
-P-T
E
T
A
-
I
G
S
L
A
-
H
Y
I
T
SAS-----------------------KKSFQPMNVNFGLFP
E
L
E
T
-
K
I
R
A
K
Q
E
R
N
E
K
L
A
E
R
A
L
N
A
I
K
K
V
A
E
EL-
30
HHSearch
87.74
53%
-87
- C1 -
3G5S
8
TRMFO_THET8
A:
[1-431]
-
M
------
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
--
V
P
V
R
L
F
E
M
R
P
--
K
-
R
M
T
P
A
------
H
G
T
D
R
F
A
E
I
V
C
----
S
N
S
-
L
G
G
E
G
E
T
N
A
K
G
L
L
Q
A
--
E
-
M
R
-
R
----
A
-----
G
----------
S
L
V
--
M
E
A
-
A
---
D
---
L
-
A
----------
R
-----
V
--------
P
--
A
G
G
A
L
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
G
H
-
P
---------------
L
L
E
V
V
R
----------------------
E
-----------------------
E
V
R
E
I
P
P
G
I
T
V
L
A
T
G
P
L
T
-
S
E
---------------------
A
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
-------
Y
L
N
C
P
M
-
T
-
E
E
E
Y
R
R
F
H
Q
A
L
L
E
A
Q
R
H
T
P
--
H
-------
F
E
A
C
V
P
V
E
E
L
A
R
R
G
Y
Q
T
L
L
F
G
P
M
K
P
V
G
L
V
D
P
R
T
G
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
-
W
P
E
Q
K
R
L
I
Q
M
I
P
G
L
E
N
A
E
I
V
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
A
G
--
V
E
--
G
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
---
L
P
P
V
A
P
-
P
-
E
E
S
M
-
L
G
G
L
V
-
R
Y
L
A
T
A
N
-----------------------
P
E
G
F
Q
P
M
Y
A
N
W
G
L
V
P
P
V
E
G
-
R
-
M
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
S
A
W
L
S
G
L
-
2
PsiBlast_PDB
86.94
54%
-89
- C1 -
3G5R
9
TRMFO_THET8
A:
[1-424]
M
E
------
R
-
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
--
V
P
V
R
L
F
E
M
R
P
--
K
-
R
M
T
P
A
------
H
G
T
D
R
F
A
E
I
V
C
----
S
N
S
-
L
G
G
E
G
E
T
N
A
K
G
L
L
Q
A
--
E
-
M
R
-
R
----
A
-----
G
----------
S
L
V
--
M
E
A
-
A
---
D
---
L
-
A
----------
R
-----
V
--------
P
--
A
G
G
A
L
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
G
H
-
P
---------------
L
L
E
V
V
R
----------------------
E
-----------------------
E
V
R
E
I
P
P
G
I
T
V
L
A
T
G
P
L
T
-
S
E
---------------------
A
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
G
Q
--
S
A
D
Y
L
N
C
P
M
-
T
-
E
E
E
Y
R
R
F
H
Q
A
L
L
E
A
------------------
C
V
P
V
E
E
L
A
R
R
G
Y
Q
T
L
L
F
G
P
M
K
P
V
G
L
V
D
P
R
T
G
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
-
W
P
E
Q
K
R
L
I
Q
M
I
P
G
L
E
N
A
E
I
V
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
A
G
--
V
E
--
G
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
---
L
P
P
V
A
P
-
P
-
E
E
S
M
-
L
G
G
L
V
-
R
Y
L
A
T
A
N
-----------------------
P
E
G
F
Q
P
M
Y
A
N
W
G
L
V
P
P
V
E
G
-
R
M
-
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
--------
1
PsiBlast_PDB
86.65
54%
-87
- C1 -
3G5Q
2
TRMFO_THET8
A:
[1-424]
M
E
------
R
-
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
--
V
P
V
R
L
F
E
M
R
P
--
K
-
R
M
T
P
A
------
H
G
T
D
R
F
A
E
I
V
C
----
S
N
S
-
L
G
G
E
G
E
T
N
A
K
G
L
L
Q
A
--
E
-
M
R
-
R
----
A
-----
G
----------
S
L
V
--
M
E
A
-
A
---
D
---
L
-
A
----------
R
-----
V
--------
P
--
A
G
G
A
L
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
G
H
-
P
---------------
L
L
E
V
V
R
----------------------
E
-----------------------
E
V
R
E
I
P
P
G
I
T
V
L
A
T
G
P
L
T
-
S
E
---------------------
A
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
G
Q
--
S
A
D
Y
L
N
C
P
M
-
T
-
E
E
E
Y
R
R
F
H
Q
A
L
L
E
A
Q
-----------------
C
V
P
V
E
E
L
A
R
R
G
Y
Q
T
L
L
F
G
P
M
K
P
V
G
L
V
D
P
R
T
G
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
-
W
P
E
Q
K
R
L
I
Q
M
I
P
G
L
E
N
A
E
I
V
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
A
G
--
V
E
--
G
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
---
L
P
P
V
A
P
-
P
-
E
E
S
M
-
L
G
G
L
V
-
R
Y
L
A
T
A
N
-----------------------
P
E
G
F
Q
P
M
Y
A
N
W
G
L
V
P
P
V
E
G
-
R
M
-
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
--------
3
PsiBlast_PDB
86.38
52%
-88
- C1 -
3G5S
8
TRMFO_THET8
A:
[2-424]
--------
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
--
V
P
V
R
L
F
E
M
R
P
--
K
-
R
M
T
P
A
------
H
G
T
D
R
F
A
E
I
V
C
----
S
N
S
-
L
G
G
E
G
E
T
N
A
K
G
L
L
Q
A
--
E
-
M
R
-
R
----
A
-----
G
----------
S
L
V
--
M
E
A
-
A
---
D
---
L
-
A
----------
R
-----
V
--------
P
--
A
G
G
A
L
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
G
H
-
P
---------------
L
L
E
V
V
R
----------------------
E
-----------------------
E
V
R
E
I
P
P
G
I
T
V
L
A
T
G
P
L
T
-
S
E
---------------------
A
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
-------
Y
L
N
C
P
M
-
T
-
E
E
E
Y
R
R
F
H
Q
A
L
L
E
A
Q
R
H
T
P
--
H
-------
F
E
A
C
V
P
V
E
E
L
A
R
R
G
Y
Q
T
L
L
F
G
P
M
K
P
V
G
L
V
D
P
R
T
G
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
-
W
P
E
Q
K
R
L
I
Q
M
I
P
G
L
E
N
A
E
I
V
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
A
G
--
V
E
--
G
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
---
L
P
P
V
A
P
-
P
-
E
E
S
M
-
L
G
G
L
V
-
R
Y
L
A
T
A
N
-----------------------
P
E
G
F
Q
P
M
Y
A
N
W
G
L
V
P
P
V
E
G
-
R
M
-
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
--------
33
HHSearch
62.99
24%
-66
- C1 -
3CP8
1
MNMG_CHLTE
A:
[20-487]
H
M
------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
--
L
H
C
L
L
I
T
S
D
L
--
S
-
A
---------------
V
A
R
M
S
C
----
N
P
A
-
I
G
G
V
A
----
K
G
Q
I
T
R
--
E
-
I
D
-
A
----
L
-----
G
GE
M
G
K
A
I
D
A
T
G
I
Q
--
F
R
M
-
L
NRS
K
---
G
-
P
----------
A
-----
M
-----------
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
-
P
---------------
N
I
D
L
L
Q
----------------------
D
T
V
I
G
V
S
A
N
SGKF
S
S
V
T
V
R-----
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
-
N
G
L
I
H
IGM
D
H
F
P
G
GRSTA
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
T
S
V
-
A
N
R
N
L
-
V
S
C
Y
L
T
K
T
T
E
K
T
H
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
C
P
S
I
E
D
------
K
I
S
R
F
-------------
P
D
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
-
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
--
T
S
--
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
---
K
E
L
I
V
L
G
R
-
D
Q
A
Y
-
I
G
V
L
I
-
D
D
L
I
T
K
E
TKEPYRMFTSSAEHRLILRHDNA
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
D
L
H
R
T
E
S
I
I
K
---------------------
32
HHSearch
59.58
22%
-57
- C1 -
3CES
-
MNMG_ECOLI
A:
[5-469]
D
P
------
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
--
Q
Q
T
L
L
L
T
H
N
I
--
D
T
L
G
Q
----------------
M
S
C
----
N
P
A
-
I
G
G
I
G
----
K
G
H
L
V
K
--
E
-
V
D
-
A
----
L
-----
G
GL
M
A
K
A
I
D
Q
A
G
I
Q
--
F
R
I
-
L
---
N
ASK
G
-
P
----------
A
-----
V
-----------
R
A
T
R
A
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
-
P
---------------
N
L
M
I
F
Q
Q
A
V
E
D
L
I
V
E
NDRVV
G
A
V
T
----
Q
-----------------------
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
-
D
G
K
I
H
I
GSI--------------
P
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
A
S
Q
H
-
P
Q
Q
-
V
P
C
Y
I
T
H
T
N
E
K
T
H
D
V
I
R
S
N
L
D
R
S
------
P
S
I
E
D
------
K
V
M
R
F
-------------
A
D
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
-
F
D
V
Q
M
Q
I
V
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
--
T
T
--
G
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
---
K
E
G
W
A
P
-
A
R
S
Q
A
Y
-
L
G
V
L
V
-
D
D
L
C
T
L
G
TKEPYRMFTSRAEYRLMLREDNA
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
R
W
A
R
F
N
E
K
-----------------------
59
Fugue
37.35
15%
-21
- C2 -
4GF7
8
?
A:
[10-379]
K
T
------
R
R
A
E
V
A
G
G
G
F
A
G
L
T
A
A
I
A
L
K
Q
N
G
--
W
D
V
R
L
H
E
K
S
S
--
E
-
L
R
A
F
G
A
G
I
Y
L
W
H
N
G
L
R
V
L
E
G
L
-------
G
-
A
L
D
D
V
L
Q
G
S
H
T
P
P
T
Y
--
E
-
T
W
-
M
----
H
-----
N
----------------
K
S
-
V
---
S
---
K
-
E
----------
T
-----
F
--------
N
--
G
L
P
W
R
I
M
T
R
S
H
L
H
D
A
L
V
N
R
A
R
A
L
G
V
---------------
D
I
S
V
N
S
----------------------
E
-----------------------
A
V
A
A
D
P
V
G
R
L
T
L
Q
T
G
E
V
L
-
E
A
---------------------------
D
L
I
V
G
--------------------
A
D
G
V
G
S
K
V
R
D
S
I
G
-----------
F
-
K
Q
D
R
W
V
S
K
D
G
L
I
R
L
I
V
P
R
M
--
K
K
E
L
G
H
G
E
W
D
N
T
I
D
M
W
N
F
W
P
R
-
V
Q
R
I
L
Y
S
P
C
N
E
---------
N
E
L
Y
L
G
L
M
A
P
A
A
D
P
R
G
S
S
V
P
-
I
D
L
E
V
W
V
E
M
F
P
F
L
E
P
C
L
I
E
A
A
K
L
K
T
A
R
Y
D
K
Y
E
T
T
K
L
D
S
W
--------------
T
R
G
K
V
A
L
V
G
D
A
A
H
A
M
C
P
--
A
L
A
Q
G
A
G
C
A
M
V
N
A
F
S
L
S
Q
D
L
E
E
GSS
V
E
D
A
L
V
-
A
-
W
E
T
R
-
I
R
P
I
T
-
D
R
C
Q
A
L
S
-----------------------
G
D
Y
A
A
N
R
S
L
S
K
G
N
M
F
T
P
A
A
-
L
E
A
A
R
Y
D
P
L
R
R
V
Y
S
W
P
Q
-----------
58
Fugue
36.65
12%
-35
* C2 *
4J33
1
KMO_YEAST
A:
[22-411]
M
S
------
E
S
V
A
I
I
G
A
G
L
V
G
C
L
A
A
L
A
F
S
K
E
G
--
Y
N
V
T
L
Y
D
F
R
Q
DP
R
-
L
D
T
T
K
------
N
K
N
L
K
S
I
N
L
A
I
S
A
R
G
I
D
A
-
L
K
S
I
D
P
D
A
C
E
H
I
L
Q
D
--
M
-
I
P
-
M
----
K
-----
G
----------
R
M
I
H
D
L
K
G
-
R
---
Q
---
E
-
S
----------
Q
-----
L
--------
Y
--
G
E
A
I
N
S
I
N
R
S
V
L
N
N
S
L
L
D
E
L
E
K
S
-
T
---------------
T
E
L
K
F
G
----------------------
H
-----------------------
K
L
V
K
I
E
-----
W
T
D
D
K
Q
I
-
C
H
---------------------
F
A
I
G
T
P
H
T
E
K
Y
D
-
F
V
I
G
C
D
G
A
Y
S
A
T
R
S
Q
M
Q
R
K
V
E
M
D
F
S
Q
E
Y
M
N
L
-
R
Y
I
E
L
Y
I
P
P
-
T
-
E
E
F
K
P
N
Y
G
G
N
F
-
A
I
A
P
D
H
L
--
H
I
W
P
R
H
K
F
M
L
I
A
L
A
---
N
S
D
G
S
F
T
S
T
F
F
G
S
K
D
Q
I
S
D
L
-
I
T
S
K
S
R
V
R
E
F
L
I
E
N
F
P
D
I
--------------------------
I
N
I
M
D
L
D
D
A
V
K
R
F
I
T
Y
P
K
E
S
L
V
C
V
N
C
K
P
Y
D
V
P
---
G
G
K
A
I
L
L
G
D
A
A
H
--
A
M
V
P
F
Y
G
Q
G
M
N
C
G
F
E
D
V
R
I
L
M
A
L
L
K
K
---
H
S
-------------
G
D
R
S
-
R
A
F
T
E
Y
T
-----------------------
Q
T
R
H
K
D
L
V
S
I
T
E
L
A
K
R
N
Y
K
-
E
M
S
H
D
V
T
S
K
R
F
L
L
R
K
-------------
41
HHSearch
35.94
22%
-49
- C1 -
3RP8
1
HPXO_KLEP7
A:
[23-183]
-
H
------
M
K
A
I
V
I
G
A
G
I
G
G
L
S
A
A
V
A
L
K
Q
S
G
--
I
D
C
D
V
Y
E
A
V
K
--
E
-
I
---------------
A
A
I
S
V
W
----
P
N
G
-
V
K
C
---
M
A
H
L
G
M
G
D
I
----
M
E
-
T
F
GGP
L
-----
R
----------
R
M
A
--
Y
R
D
-
F
R--
S
---
G
-
E
----------
N
M
T
Q
--
F
S
L
A
P
L
I
E
R
T
--
G
S
R
P
C
P
V
S
R
A
E
L
Q
R
E
M
L
D
Y
W
G
R
D
-
S
VQFGKRVT
R
C
E
E
D
AD
G
V
T
V
W
F
----------------------
T
-----------------------
D
G
S
S
A
S
G
D
L
L
I
A
A
D
G
S
H
S
-
A
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
35.43
21%
-37
- C1 -
3E1T
1
?
A:
[6-236]
E
V
------
F
D
L
I
V
I
G
G
G
P
G
G
S
T
L
A
S
F
V
A
M
R
G
--
H
R
V
L
L
L
E
R
E
A
--
F
-
P
R
H
Q
I
------------
G
E
S
L
L
----
P
A
T
-
V
H
--
G
I
C
A
M
L
G
L
T
-
D
--
E
-
M
K
-
R
----
A
GFPIK
R
----------
G
G
T
--
F
R
W
G
K
---
E
P
E
-
P
-
W
----------
T
F
G
FTR
H
PDD-----
P
--
Y
G
F
A
Y
Q
V
E
R
A
R
F
D
D
M
L
L
R
N
S
E
R
K
-----------------
G
V
D
V
R
E
----------------------
R
HEVI
D
V
L
F
E
GERAV
G
V
R
Y
R
N
TEG
V
E
L
M
A
H
A
R
F
I
V
D
A
S
G
N
R
T
-
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
35.27
26%
-43
- C1 -
3I3L
1
?
A:
[22-204]
T
R
------
S
K
V
A
I
I
G
G
G
P
A
G
S
V
A
G
L
T
L
H
K
L
G
--
H
D
V
T
I
Y
E
R
S
A
--
F
-
P
R
Y
------------
R
V
G
E
S
L
L
----
P
G
T
-
M
S
I
---
L
N
R
L
G
L
Q
E
---
K
-
I
D
-
A
----
Q
NYVKK
P
----------
S
A
T
--
F
L
W
-
G
---
Q
D--
Q
-
A
P
W
T
F
S
FAAPA
P
-----
W
--------
V
--
F
D
H
A
V
Q
V
K
R
E
E
F
D
K
L
L
L
D
E
A
R
S
R
-----------------
G
I
T
V
H
E
----------------------
E
TPVTDVDLSDPD
R
V
V
L
T
V
R
R
GG-
E
S
V
T
V
E
S
D
F
V
I
D
A
G
G
S
G
G
-
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
34.14
18%
-20
- C1 -
3OZ2
8
GGR_THEAC
A:
[3-163]
E
T
------
Y
D
V
L
V
V
G
G
G
P
G
G
S
T
A
A
R
Y
A
A
K
Y
G
--
L
K
T
L
M
I
E
K
R
P
--
E
-
I
G
S
P
V
------
R
----
C
G
E
G
L
S
----
K
G
I
-
L
N
------
E
A
D
I
K
A
D
RS
F
I
A
N
-
E
----
V
-----
K
----------
G
A
R
--
I
Y
G
-
P
---
S
---
E
-
K
R---------
P
I
I
L
Q
S
E
KA------
G
--
N
E
V
G
Y
V
L
E
R
D
K
F
D
K
H
L
A
A
L
A
A
K
A
-
G
----------------
A
D
V
W
V
KSPAL
G
V
I
K
E
NGKVA
G
A
K
I
R
H
N
N
-----------------------
E
I
V
D
V
R
A
K
M
V
I
A
A
D
G
F
E
S
-
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
34.05
14%
-24
- C2 -
1GCU
-
BIEA_RAT
A:
[1-292]
M
D
AEPKR
K
F
G
V
V
V
V
G
V
G
R
A
G
S
V
R
L
R
D
L
K
D
P
R
--
S
A
-
A
F
L
N
L
I
G
--
F
-
V
S
R
R
E
------
L
G
S
L
D
E
V
R
Q
I
S
----
L
E
D
-
A
L
R
S
Q
E
I
D
V
A
Y
I
C
S
------------------------------------------------------------------------------------------------------
E
---------------
S
S
S
H
E
D
----------------------
Y
-----------------------
I
R
Q
F
L
Q
A
G
K
H
V
L
V
E
Y
P
M
T
L
S
F
---------------------
A
A
A
Q
E
L
W
E
L
A
A
Q
K
G
R
V
L
H
E
E
H
V
E
L
L
M
E
E
F
E
F
L
R
R
E
V
L
G
K
E
L
L
K
G
-
S
L
R
F
T
A
S
P
L
-
E
-
E
E
R
F
---------------------------
G
F
P
A
F
S
G
I
S
R
L
T
W
L
V
S
L
F
G
E
L
S
L
I
S
A
T
L
E
E
R
K
E
D
Q
Y
M
K
M
T
V
Q
L
E
T
Q
N
K
G
---------
L
L
S
-
W
I
E
E
K
-----
G
P
G
L
K
R
N
R
Y
V
N
F
Q
F
T
S
G
S
L
--
E
E
V
P
S
V
G
V
N
K
N
I
F
L
K
D
Q
D
I
F
V
Q
K
L
L
D
--
Q
V
--
S
------------------------------------------------------------------------------------------------
A
E
D
L
A
A
E
K
K
R
I
M
H
C
L
G
L
A
S
D
I
Q
K
L
C
H
39
HHSearch
32.70
16%
-25
- C1 -
2QA2
1
?
A:
[11-168]
S
D
------
A
S
V
I
V
V
G
A
G
P
A
G
L
M
L
A
G
E
L
R
L
G
G
--
V
D
V
M
V
L
E
Q
L
P
--
Q
-
R
T
G
E
-----------
S
R
G
L
G
F
T
----
A
R
T
-
M
---
E
V
F
D
Q
R
G
I
L
P
---
A
-
F
G
-
P
----
V
E
----
T
----------
S
T
Q
--
G
H
F
-
G
-------
G
-
R
----------
P
-----
V
DFGVL---
E
GA
H
Y
G
V
K
A
V
P
Q
S
T
T
E
S
V
L
E
E
W
A
L
G
R
-----------------
G
A
E
L
L
R
----------------------
G
HTVRALTDEGD
H
V
V
V
E
V
E
G
PD--
G
P
R
S
L
T
T
R
Y
V
V
G
C
D
G
G
R
S
-
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
32.42
30%
47
- C1 -
2XDO
2
?
A:
[25-64]
S
D
------
K
N
V
A
I
I
G
G
G
P
V
G
L
T
M
A
K
L
L
Q
Q
N
G
--
I
D
V
S
V
Y
E
R
D
N
--
D
-
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
32.37
21%
-39
- C1 -
3NIX
1
?
A:
[4-170]
E
K
------
V
D
V
L
V
I
G
A
G
P
A
G
T
V
A
A
S
L
V
N
K
S
G
--
F
K
V
K
I
V
E
K
Q
K
--
F
-
P
R
F
------------
V
I
G
E
S
L
L
----
P
R
C
-
M
E
---
H
L
D
E
A
G
F
L
D
---
A
-
V
K
-
A
----
Q
GFQQK
F
----------
G
A
K
--
F
V
R
-
G
---
K
---
E
I
A
----------
D
-----
F
N
FSDQFSN
G
--
W
N
W
T
W
Q
V
P
R
G
N
F
D
K
T
L
A
D
E
A
A
R
Q
-----------------
G
V
D
V
E
Y
----------------------
E
V
G
V
T
D
IKFFGT
D
S
V
T
T
I
E
D
ING-
N
K
R
E
I
E
A
R
F
I
I
D
A
S
G
Y
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
32.35
39%
-59
- C1 -
3CP8
1
MNMG_CHLTE
C:
[327-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
T
S
L
P
-
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
--
T
S
--
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
---
K
E
L
I
V
L
-
G
-
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
-----------------------
K
E
P
Y
R
-------------------------------------------
21
PsiBlast_CBE
32.08
39%
-57
- C1 -
3CP8
1
MNMG_CHLTE
D:
[327-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
T
S
L
P
-
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
--
T
S
--
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
---
K
E
L
I
V
L
-
G
-
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
-----------------------
K
E
P
Y
R
-------------------------------------------
4
PsiBlast_PDB
31.97
39%
-59
- C1 -
3CP8
1
MNMG_CHLTE
A:
[327-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
T
S
L
P
-
E
D
I
Q
I
A
G
L
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
--
T
S
--
G
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
---
K
E
L
I
V
L
-
G
-
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
-----------------------
K
E
P
Y
R
-------------------------------------------
37
HHSearch
31.95
16%
-42
- C1 -
3C4A
1
VIOD_CHRVO
A:
[1-151]
--------
M
K
I
L
V
I
G
A
G
P
A
G
L
V
F
A
S
Q
L
K
Q
A
R
PL
W
A
I
D
I
V
E
K
N
D
--
E
-
Q
E
V
-
L
----------
G
W
G
V
V
L
P
----
G
R
P
G
Q
H
P
A
N
P
L
S
Y
L
D
A
P
E
R
--
L
-
N
P
Q
F
----
L
-----
E
----------
D
F
K
--
L
V
H
-
H
---
N
---
E
-
P
----------
S
-----
L
MS------
T
--
G
V
L
L
C
G
V
E
R
R
G
L
V
H
A
L
R
D
K
C
R
S
Q
-----------------
G
I
A
I
R
F
----------------------
E
S
P
L
L
E
HG----------------
E
L
P
L
A
D
Y
D
L
V
V
L
A
N
G
V
N
H
-
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------