@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1286: (2016-03-23 )
MNRNEYNDDSIQVLEGLEAVRKRPAMYIGSTDVRGLHHLVYEIVDNSVDETLAGFGKKIVVTLHEDGSVSVSDEGRGMPVGMHKTGKSTVEVILTVLHAGGKFGQEGGYKTSGGLHGVGSSVVNALSEWLVVTINRDGATYQQKFKDGGKPDGTLKKIGKSKATGTTIRFKPDPAIFPTTSFNYETLSERLRESAFLLKGMLIELIDERVGMAEAFHFEEGVKNFVEYINEGKDVLHPVASFEGENATIEVEMAFQFNDGYSENILSFVNNVRTRGAGSHESGMKAAMTRIFNDYARRVNLLKEKDKNLEGSDIREGLSAVLSIRVPEKILQFEGQTKEKLGTQEARQAVDAVVAEHLAYFLAENPETSSLLVKKAVKAREAREAARKAREETRNGKKKKRSETLLSGKLTPAQSRNPNKNELYLVEGDSAGGSAKQGRDRRFQAILPLRGKVINTEKAKLQDILKNEEISTIIHTVGAGVGTEFDVEDCNYDKVVIMTDADTDGAHIQVLLLTFFYRYMRPLVEAGKVFIALPPLYKVSRGSGKKEVIEYAWTDEELDSAIQKIGKGYMIQRYKGLGEMNADQLWETTMNPDTRTLIRVRVDDSARAERRVATLMGDKVEPRRQWIEKHVEFSMEDSQNILENENMMVEEAKDI
Atome Classification :
(62 SA)
.........10-........20........30-.-.-......40........50......---..60......--..70........80-..-.-.-..-..90........100.......110--.........120.......130.......140.......150.--......---160.--.--.-----......170.....-.-.180.......190.......200.......210--...---------------....220.......230....--..-.240---.......250.......260.....-...270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNRNEYND
D
S
I
-
Q
V
L
E
G
L
E
A
V
R
KRP
A
M
Y
IGS
T
-
D
-
V
-
R
G
L
H
H
L
V
Y
E
I
V
DN
S
V
D
E
T
L
A
GFG
K
---
K
I
V
V
T
L
HEDG--
S
V
SVSDEGRGMPVG-MH-K-T-G
K
-
S
T
V
E
V
I
L
T
V
L
H
AGGKFGQEGGYK----TSGGLH
G
V
G
S
S
V
V
N
A
L
S
E
W
L
V
V
T
INRDG
A
T
Y
Q
Q
K
F
KDGGKPD
G
--
T
L
K
K
IG---K--S--K--A-----TG
T
T
I
R
FKPDPAIF-P-TTSF
N
Y
E
T
L
S
E
R
L
R
E
S
A
F
L
L
K
G
M
L
I
E
L
I
D
E
RVG
M
--
A
E
A
---------------
F
H
F
E
E
G
V
K
N
F
V
E
Y
I
NE
G
K
D
V
L
--
H
P
-
V
A
SF---EGE
N
A
T
I
E
V
E
M
A
F
Q
FNDG-Y
S
E
N
I
L
-
S
F
V
N
N
V
RTRGAGSHE
S
G
M
K
A
A
M
T
R
I
F
N
D
Y
A
R
R
V
N
L
L
K
E
KDKNLE
G
S
D
I
R
E
G
L
S
A
V
L
SIRV
P
E
K
I
L
Q
FEG
Q
T
K
E
KL
G
T
Q
E
A
R
Q
A
V
D
A
V
V
A
E
H
L
A
Y
F
L
AENPE
T
S
S
L
L
V
K
K
A
V
K
A
R
E
A
R
E
A
A
R
K
A
R
E
E
TRNG
K
K
K
K
RSETLLSGKLTPAQSRNPNK
N
E
L
Y
L
V
EGDSAGGSAKQGRDR
R
F
Q
A
ILPLR
G
K
VIN
T
E
K
A
K
L
Q
D
I
L
KN
E
E
I
S
T
I
I
H
T
VGAGVGTEFDVEDCNY
D
K
V
V
I
M
TDADTDG
A
H
I
Q
V
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
EA
G
K
V
F
I
ALPPL
Y
K
VSRGS
G
K
K
E
V
I
E
Y
AW
T
D
E
E
L
D
S
A
I
Q
K
IGKGY
M
I
Q
R
Y
KGLGEM
N
A
D
Q
L
W
E
TTMNPDT
R
T
L
I
R
V
RVDDS
A
R
A
E
R
R
V
A
T
L
MGDK
V
E
P
R
R
Q
W
I
E
K
HVEFSMED
S
Q
N
I
LENENM
M
V
E
E
AKDI
1
PsiBlast_PDB
91.77
70%
-89
- C4 -
4JUO
4
PARE_STRPN
C:
[47-663]
-------------------
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
---
D
---
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
-------------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
---------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
--
T
L
K
K
I
G
TAP
K
--
S
--
K
--------
T
G
T
K
V
T
F
M
P
D
A
T
I
F
-
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
D
E
--
A
I
E
---------------
F
H
Y
E
--
V
Q
D
F
V
S
Y
L
N
E
D
K
E
I
L
--
T
P
-
V
L
Y
F
---
E
G
E
D
N
G
F
Q
V
E
V
A
L
Q
Y
N
D
G
-
F
S
D
N
I
L
-
S
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
L
K
E
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
E
E
H
L
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
-------------------
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
-
P
P
L
Y
K
-----------
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
-------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
---------------------
111
Fugue
69.66
50%
-61
- C3 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
--
S
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
-
P
-
E
E
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
-
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
-
H
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
--
P
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Fugue
69.24
50%
-58
- C3 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
--
S
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
-
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
-
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
-
H
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
---E-
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
T
N
-
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
68.66
47%
-63
- C3 -
3ZKD
3
GYRB_MYCTU
F:
[15-426]
---
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
------K
V
K
S
R
T
---------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
------
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
68.56
48%
-60
- C3 -
4WUD
4
GYRB_ECOLI
A:
[3-375]
----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
68.50
48%
-71
- C3 -
4ZVI
3
?
A:
[1-361]
-----------------
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
------------------------
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
-
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.44
48%
-60
- C3 -
4XTJ
5
GYRB_ECOLI
A:
[3-375]
----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
68.31
47%
-62
- C3 -
3ZKB
4
GYRB_MYCTU
B:
[15-429]
---
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
--------VK
S
R
T
----------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
68.22
47%
-64
- C3 -
3ZKB
3
GYRB_MYCTU
D:
[14-427]
--
Q
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
Q
-----STAPHK
V
K
S
R
T
----
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
68.10
47%
-66
- C3 -
3ZKD
3
GYRB_MYCTU
G:
[15-425]
---
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
-------PHK
V
K
S
R
T
-------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
----
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.03
48%
-60
- C3 -
4WUB
5
GYRB_ECOLI
A:
[3-375]
----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
67.92
47%
-62
- C3 -
3ZKD
3
GYRB_MYCTU
C:
[17-426]
-----
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
Q
DE---
R
A
A
E
S
T
APHK
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
--
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
67.88
47%
-63
- C3 -
3ZKB
4
GYRB_MYCTU
C:
[16-430]
----
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
-------A
P
H
K
V
K
S
R
T
------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
67.71
48%
-58
- C3 -
4WUC
5
GYRB_ECOLI
A:
[3-375]
----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
67.59
47%
-63
- C3 -
3ZKB
3
GYRB_MYCTU
A:
[16-428]
----
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
--------PHK
V
K
S
R
T
-------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
67.43
49%
-60
- C3 -
1EI1
5
GYRB_ECOLI
A:
[9-375]
----------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
67.41
47%
-62
- C3 -
3ZKD
3
GYRB_MYCTU
E:
[17-427]
-----
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
Q
-----PHKV
K
S
R
T
-------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
--
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
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W
F
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A
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P
T
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A
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V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
67.10
47%
-64
- C3 -
1KIJ
3
?
A:
[7-389]
---------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
-
G
-
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-
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Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
T
---
E
I
L
V
R
L
N
E
D
G
--
S
L
T
V
E
D
N
G
R
G
I
P
V
D
-
L
M
-
P
E
E
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K
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E
V
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Y
N
T
L
H
S
G
G
K
F
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Q
G
-
A
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K
----
V
S
G
G
L
H
G
V
G
A
S
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V
N
A
L
S
E
W
T
V
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E
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F
R
E
G
K
H
H
R
I
A
F
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R
G
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V
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E
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---
L
R
V
V
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EA-
P
--
R
--
G
--
K
-----
T
G
T
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T
F
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P
D
P
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I
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-
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-
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L
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R
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A
Y
L
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A
G
L
K
L
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F
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D
R
Q
H
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K
--
E
E
V
---------------
F
L
D
K
G
G
V
A
S
F
A
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A
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A
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G
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L
--
Y
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---
R
G
T
H
G
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V
E
V
E
V
G
F
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Q
G
-
Y
N
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D
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--
Q
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L
L
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A
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A
A
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A
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A
A
R
K
A
R
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------