@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1286: (2016-03-23 )
MNRNEYNDDSIQVLEGLEAVRKRPAMYIGSTDVRGLHHLVYEIVDNSVDETLAGFGKKIVVTLHEDGSVSVSDEGRGMPVGMHKTGKSTVEVILTVLHAGGKFGQEGGYKTSGGLHGVGSSVVNALSEWLVVTINRDGATYQQKFKDGGKPDGTLKKIGKSKATGTTIRFKPDPAIFPTTSFNYETLSERLRESAFLLKGMLIELIDERVGMAEAFHFEEGVKNFVEYINEGKDVLHPVASFEGENATIEVEMAFQFNDGYSENILSFVNNVRTRGAGSHESGMKAAMTRIFNDYARRVNLLKEKDKNLEGSDIREGLSAVLSIRVPEKILQFEGQTKEKLGTQEARQAVDAVVAEHLAYFLAENPETSSLLVKKAVKAREAREAARKAREETRNGKKKKRSETLLSGKLTPAQSRNPNKNELYLVEGDSAGGSAKQGRDRRFQAILPLRGKVINTEKAKLQDILKNEEISTIIHTVGAGVGTEFDVEDCNYDKVVIMTDADTDGAHIQVLLLTFFYRYMRPLVEAGKVFIALPPLYKVSRGSGKKEVIEYAWTDEELDSAIQKIGKGYMIQRYKGLGEMNADQLWETTMNPDTRTLIRVRVDDSARAERRVATLMGDKVEPRRQWIEKHVEFSMEDSQNILENENMMVEEAKDI
Atome Classification :
(62 SA)
.........10-........20........30-.-.-......40........50......---..60......--..70........80-..-.-.-..-..90........100.......110--.........120.......130.......140.......150.--......---160.--.--.-----......170.....-.-.180.......190.......200.......210--...---------------....220.......230....--..-.240---.......250.......260.....-...270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNRNEYND
D
S
I
-
Q
V
L
E
G
L
E
A
V
R
KRP
A
M
Y
IGS
T
-
D
-
V
-
R
G
L
H
H
L
V
Y
E
I
V
DN
S
V
D
E
T
L
A
GFG
K
---
K
I
V
V
T
L
HEDG--
S
V
SVSDEGRGMPVG-MH-K-T-G
K
-
S
T
V
E
V
I
L
T
V
L
H
AGGKFGQEGGYK----TSGGLH
G
V
G
S
S
V
V
N
A
L
S
E
W
L
V
V
T
INRDG
A
T
Y
Q
Q
K
F
KDGGKPD
G
--
T
L
K
K
IG---K--S--K--A-----TG
T
T
I
R
FKPDPAIF-P-TTSF
N
Y
E
T
L
S
E
R
L
R
E
S
A
F
L
L
K
G
M
L
I
E
L
I
D
E
RVG
M
--
A
E
A
---------------
F
H
F
E
E
G
V
K
N
F
V
E
Y
I
NE
G
K
D
V
L
--
H
P
-
V
A
SF---EGE
N
A
T
I
E
V
E
M
A
F
Q
FNDG-Y
S
E
N
I
L
-
S
F
V
N
N
V
RTRGAGSHE
S
G
M
K
A
A
M
T
R
I
F
N
D
Y
A
R
R
V
N
L
L
K
E
KDKNLE
G
S
D
I
R
E
G
L
S
A
V
L
SIRV
P
E
K
I
L
Q
FEG
Q
T
K
E
KL
G
T
Q
E
A
R
Q
A
V
D
A
V
V
A
E
H
L
A
Y
F
L
AENPE
T
S
S
L
L
V
K
K
A
V
K
A
R
E
A
R
E
A
A
R
K
A
R
E
E
TRNG
K
K
K
K
RSETLLSGKLTPAQSRNPNK
N
E
L
Y
L
V
EGDSAGGSAKQGRDR
R
F
Q
A
ILPLR
G
K
VIN
T
E
K
A
K
L
Q
D
I
L
KN
E
E
I
S
T
I
I
H
T
VGAGVGTEFDVEDCNY
D
K
V
V
I
M
TDADTDG
A
H
I
Q
V
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
EA
G
K
V
F
I
ALPPL
Y
K
VSRGS
G
K
K
E
V
I
E
Y
AW
T
D
E
E
L
D
S
A
I
Q
K
IGKGY
M
I
Q
R
Y
KGLGEM
N
A
D
Q
L
W
E
TTMNPDT
R
T
L
I
R
V
RVDDS
A
R
A
E
R
R
V
A
T
L
MGDK
V
E
P
R
R
Q
W
I
E
K
HVEFSMED
S
Q
N
I
LENENM
M
V
E
E
AKDI
1
PsiBlast_PDB
91.77
70%
-89
- C4 -
4JUO
4
PARE_STRPN
C:
[47-663]
-------------------
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
---
D
---
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
-------------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
---------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
--
T
L
K
K
I
G
TAP
K
--
S
--
K
--------
T
G
T
K
V
T
F
M
P
D
A
T
I
F
-
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
D
E
--
A
I
E
---------------
F
H
Y
E
--
V
Q
D
F
V
S
Y
L
N
E
D
K
E
I
L
--
T
P
-
V
L
Y
F
---
E
G
E
D
N
G
F
Q
V
E
V
A
L
Q
Y
N
D
G
-
F
S
D
N
I
L
-
S
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
L
K
E
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
E
E
H
L
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
-------------------
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
-
P
P
L
Y
K
-----------
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
-------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
---------------------
111
Fugue
69.66
50%
-61
- C3 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
--
S
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
-
P
-
E
E
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
-
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
-
H
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
--
P
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Fugue
69.24
50%
-58
- C3 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
--
S
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
-
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
-
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
-
H
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
---E-
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
T
N
-
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
68.66
47%
-63
- C3 -
3ZKD
3
GYRB_MYCTU
F:
[15-426]
---
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
------K
V
K
S
R
T
---------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
------
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
68.56
48%
-60
- C3 -
4WUD
4
GYRB_ECOLI
A:
[3-375]
----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
68.50
48%
-71
- C3 -
4ZVI
3
?
A:
[1-361]
-----------------
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
------------------------
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
-
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.44
48%
-60
- C3 -
4XTJ
5
GYRB_ECOLI
A:
[3-375]
----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
68.31
47%
-62
- C3 -
3ZKB
4
GYRB_MYCTU
B:
[15-429]
---
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
--------VK
S
R
T
----------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
68.22
47%
-64
- C3 -
3ZKB
3
GYRB_MYCTU
D:
[14-427]
--
Q
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
Q
-----STAPHK
V
K
S
R
T
----
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
68.10
47%
-66
- C3 -
3ZKD
3
GYRB_MYCTU
G:
[15-425]
---
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
-------PHK
V
K
S
R
T
-------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
----
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.03
48%
-60
- C3 -
4WUB
5
GYRB_ECOLI
A:
[3-375]
----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
67.92
47%
-62
- C3 -
3ZKD
3
GYRB_MYCTU
C:
[17-426]
-----
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
Q
DE---
R
A
A
E
S
T
APHK
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
--
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
67.88
47%
-63
- C3 -
3ZKB
4
GYRB_MYCTU
C:
[16-430]
----
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
-------A
P
H
K
V
K
S
R
T
------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
67.71
48%
-58
- C3 -
4WUC
5
GYRB_ECOLI
A:
[3-375]
----
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
67.59
47%
-63
- C3 -
3ZKB
3
GYRB_MYCTU
A:
[16-428]
----
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
--------PHK
V
K
S
R
T
-------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
67.43
49%
-60
- C3 -
1EI1
5
GYRB_ECOLI
A:
[9-375]
----------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
67.41
47%
-62
- C3 -
3ZKD
3
GYRB_MYCTU
E:
[17-427]
-----
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
T
Q
-----PHKV
K
S
R
T
-------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
--
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
67.10
47%
-64
- C3 -
1KIJ
3
?
A:
[7-389]
---------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
-
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
T
---
E
I
L
V
R
L
N
E
D
G
--
S
L
T
V
E
D
N
G
R
G
I
P
V
D
-
L
M
-
P
E
E
-
G
K
-
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
-
A
Y
K
----
V
S
G
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
S
R
G
E
V
T
E
P
---
L
R
V
V
G
EA-
P
--
R
--
G
--
K
-----
T
G
T
R
V
T
F
K
P
D
P
E
I
F
-
G
-
N
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
H
G
K
--
E
E
V
---------------
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
--
Y
E
K
P
F
L
I
---
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
-
Y
N
A
E
I
L
-
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
A
L
R
A
A
Q
A
R
E
A
A
R
K
A
R
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
67.06
49%
-59
- C3 -
1EI1
6
GYRB_ECOLI
B:
[9-375]
----------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.83
47%
-62
- C3 -
3ZKD
3
GYRB_MYCTU
A:
[17-429]
-----
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
G
--
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
-
S
-
G
I
-
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
-
Y
A
----
I
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
-
E
P
L
G
---
L
K
Q
G
A
---
P
--
T
--
K
--
K
-----
T
G
S
T
V
R
F
W
A
D
P
A
V
F
-
E
-
T
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
--------HKVK
S
R
T
--------
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
N
A
I
--
H
S
S
I
V
D
F
---
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
-
Y
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
-----
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
66.62
45%
-59
- C3 -
1KIJ
3
?
B:
[7-372]
---------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
-
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
T
---
E
I
L
V
R
L
N
E
D
G
--
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
-
E
-
E
-
G
K
-
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
-
E
Q
G
A
Y
K
----
V
S
G
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
S
R
G
E
V
T
E
---
P
L
R
V
V
G
---
E
--
A
--
P
RG
K
-----
T
G
T
R
V
T
F
K
P
D
P
E
I
F
-
G
-
N
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
H
G
K
--
E
E
V
---------------
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
--
Y
E
-
K
P
F
L
I--
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
-
Y
N
A
E
I
L
-
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
66.10
45%
-64
- C3 -
1KIJ
3
?
A:
[7-372]
---------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
-
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
T
---
E
I
L
V
R
L
N
E
D
G
--
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
-
E
-
E
-
G
K
-
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
-
E
Q
G
A
Y
K
----
V
S
G
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
S
R
G
E
V
T
E
---
P
L
R
V
V
G
---
E
--
A
--
P
RG
K
-----
T
G
T
R
V
T
F
K
P
D
P
E
I
F
-
G
-
N
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
H
G
K
--
E
E
V
---------------
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
D
L
L
--
Y
E
-
K
P
F
L
I
--
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
-
Y
N
A
E
I
L
-
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
63.73
36%
-61
- C3 -
1S16
4
PARE_ECOLI
A:
[4-383]
----
T
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
T
------
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
---
R
V
D
V
I
L
H
A
D
Q
--
S
L
E
V
I
D
D
G
R
G
M
P
V
D
-
I
H
-
P
E
E
-
G
V
-
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
-
N
Y
Q
----
F
S
G
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
Q
D
---
L
Q
V
V
G
---
T
CG
K
--
R
--
N
-----
T
G
T
S
V
H
F
W
P
D
E
T
F
F
-
D
-
S
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
N
T
--
E
Q
R
---------------
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
P
T
L
--
P
E
K
P
F
I
G
---
N
F
A
G
D
T
E
A
V
D
W
A
L
L
W
L
P
E
G
G
E
L
L
T
E
-
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
-
G
V
K
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
--
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
63.67
35%
-58
- C3 -
1S16
4
PARE_ECOLI
A:
[5-383]
-----
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
---
T
-
D
-
T
-
T
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
---
R
V
D
V
I
L
H
A
D
Q
--
S
L
E
V
I
D
D
G
R
G
M
P
V
D
-
I
H
P
E
-
E
-
G
V
-
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
-
N
Y
Q
----
F
S
G
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
Q
---
D
L
Q
V
V
G
---
T
--
C
GK
R
--
N
-----
T
G
T
S
V
H
F
W
P
D
E
T
F
F
-
D
-
S
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
N
T
--
E
Q
R
---------------
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
P
T
L
PE
K
P
F
I
G
N
F
---
A
G
D
T
E
A
V
D
W
A
L
L
W
-
L
P
E
G
-
G
E
L
L
T
E
-
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
G
V
K
-
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
63.55
38%
-63
- C3 -
4HYM
1
?
A:
[7-377]
--------
K
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
-
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
S
---
K
I
N
I
T
L
Y
E
D
N
--
S
I
E
V
A
D
D
G
R
G
M
P
V
D
-
I
H
-
P
-
E
-
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
N
-----------
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
E
D
G
F
K
T
K
D
LE
I
I
D
N
V
G
---
K
-----
K
--
N
-----
T
G
T
K
I
R
F
W
P
N
K
K
Y
F
-
D
-
D
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
E
I
K
K
E
--
K
L
T
---------------
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
L
E
A
E
T
L
----
P
-
A
E
P
F
IID
N
F
S
N
G
D
S
Y
L
D
A
V
F
C
W
C
E
D
-
P
S
E
S
I
K
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
E
K
-
N
S
----
N
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
V
A
Q
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
63.40
38%
-68
- C3 -
4KQV
7
?
A:
[7-378]
--------
K
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
-
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
S
---
K
I
N
I
T
L
Y
E
D
N
--
S
I
E
V
A
D
D
G
R
G
M
P
V
D
-
I
H
-
P
-
E
-
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
N
---------------
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
E
D
G
F
K
T
K
D
LE
I
I
D
N
V
G
---
K
-----
K
--
N
-----
T
G
T
K
I
R
F
W
P
N
K
K
Y
F
-
D
-
D
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
E
I
K
K
E
--
K
L
T
---------------
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
-----
L
----
P
-
A
E
P
F
IID
N
F
S
N
G
D
S
Y
L
D
A
V
F
C
W
C
-----
E
S
I
K
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
E
K
-
N
S
L
S
V
K
N
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
V
A
Q
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
62.86
35%
-58
- C3 -
1S16
4
PARE_ECOLI
B:
[5-383]
-----
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
---
T
-
D
-
T
-
T
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
---
R
V
D
V
I
L
H
A
D
Q
--
S
L
E
V
I
D
D
G
R
G
M
P
V
D
-
I
H
P
E
-
E
-
G
V
-
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
-
N
Y
Q
----
F
S
G
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
Q
---
D
L
Q
V
V
G
---
T
--
C
GK
R
--
N
-----
T
G
T
S
V
H
F
W
P
D
E
T
F
F
-
D
-
S
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
N
T
--
E
Q
R
---------------
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
P
T
L
PE
K
P
F
I
G
N
F
---
A
G
D
T
E
A
V
D
W
A
L
L
W
-
L
P
E
G
-
G
E
L
L
T
E
-
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
G
V
K
-
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
62.56
38%
-67
- C3 -
4HXZ
1
?
A:
[8-378]
---------
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
-
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
S
---
K
I
N
I
T
L
Y
E
D
N
--
S
I
E
V
A
D
D
G
R
G
M
P
V
D
-
I
H
-
P
-
E
-
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
---------------
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
E
D
G
F
K
T
K
D
LE
I
I
D
N
V
G
---
K
-----
K
--
N
-----
T
G
T
K
I
R
F
W
P
N
K
K
Y
F
-
D
-
D
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
E
I
K
K
E
--
K
L
T
---------------
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
L
E
A
E
T
L
----
P
-
A
E
P
F
IID
N
F
S
N
G
D
S
Y
L
D
A
V
F
C
W
C
E
D
-
P
S
E
S
I
K
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
E
K
-
N
S
L
S
V
K
N
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
V
A
Q
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
55.35
68%
-72
- C3 -
5BOD
1
?
A:
[17-225]
------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
-
M
-
G
I
-
P
T
V
E
V
I
F
T
I
L
H
A
G
-----------------------
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
--
T
L
K
K
I
G
TAL
K
--
S
--
K
--------
T
G
T
K
V
T
F
M
P
D
A
T
I
F
-
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
D
E
--
A
I
E
---------------
F
H
Y
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
55.34
68%
-71
- C3 -
4MOT
1
?
A:
[17-225]
------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
-
M
-
G
I
-
P
T
V
E
V
I
F
T
I
L
H
A
----------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
--
T
L
K
K
I
G
TAL
K
--
S
--
K
--------
T
G
T
K
V
T
F
M
P
D
A
T
I
F
-
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
D
E
--
A
I
E
---------------
F
H
Y
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
54.82
68%
-70
- C3 -
4EM7
1
?
A:
[17-225]
------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
-
M
-
G
I
-
P
T
V
E
V
I
F
T
I
L
H
A
----------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
--
T
L
K
K
I
G
TAL
K
--
S
--
K
--------
T
G
T
K
V
T
F
M
P
D
A
T
I
F
-
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
D
E
--
A
I
E
---------------
F
H
Y
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
54.76
68%
-68
- C3 -
4MB9
2
?
A:
[17-225]
------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
-
M
-
G
I
-
P
T
V
E
V
I
F
T
I
L
H
A
G
-----------------
G
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
--
T
L
K
K
I
G
TAL
K
--
S
--
K
--------
T
G
T
K
V
T
F
M
P
D
A
T
I
F
-
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
D
E
--
A
I
E
---------------
F
H
Y
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
54.42
68%
-69
- C3 -
4LPB
1
?
A:
[17-225]
------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
-
M
-
G
I
-
P
T
V
E
V
I
F
T
I
L
H
A
----------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
--
T
L
K
K
I
G
TAL
K
--
S
--
K
--------
T
G
T
K
V
T
F
M
P
D
A
T
I
F
-
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
D
E
--
A
I
E
---------------
F
H
Y
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
53.79
68%
-68
- C3 -
4MBC
1
?
A:
[17-225]
------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
G
--
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
-
M
-
G
I
-
P
T
V
E
V
I
F
T
I
L
H
A
----------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
--
T
L
K
K
I
G
TAL
K
--
S
--
K
--------
T
G
T
K
V
T
F
M
P
D
A
T
I
F
-
S
-
T
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
D
E
--
A
I
E
---------------
F
H
Y
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
53.09
54%
-60
- C3 -
3G7E
1
GYRB_ECOLI
A:
[1-203]
----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
52.01
59%
-56
- C3 -
4URM
1
?
A:
[25-217]
-----------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
N
---
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
-
I
Q
E
K
-
M
-
G
R
-
P
A
V
E
V
I
L
T
V
L
H
A
G
G
K
------------------
G
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
-
G
V
P
Q
F
--
D
L
K
E
V
G
---
T
--
T
--
D
--
K
-----
T
G
T
V
I
R
F
K
A
D
G
E
I
F
-
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
51.98
69%
-64
- C3 -
4URN
1
?
C:
[19-224]
----------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
K
-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
N
---
E
I
D
V
T
I
N
K
D
G
--
S
I
S
I
E
D
N
G
R
G
M
P
T
G
-
I
H
-
K
-
S
-
G
K
-
P
T
V
E
V
I
F
T
V
L
-------------------------
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
G
N
I
Y
H
Q
S
F
K
N
G
G
S
P
S
S
--
G
L
V
K
K
G
---
K
--
T
--
K
--
K
-----
T
G
T
K
V
T
F
K
P
D
D
T
I
F
K
A
-
S
T
S
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R
S
G
K
E
R
Q
E
H
---------------
Y
H
Y
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
51.93
59%
-59
- C3 -
4URM
1
?
B:
[25-217]
-----------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
N
---
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
-
I
Q
E
K
-
M
-
G
R
-
P
A
V
E
V
I
L
T
V
L
H
A
G
G
K
F
G
-----------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
-
G
V
P
Q
F
--
D
L
K
E
V
G
---
T
--
T
--
D
--
K
-----
T
G
T
V
I
R
F
K
A
D
G
E
I
F
-
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
51.86
53%
-63
- C3 -
1AJ6
1
GYRB_ECOLI
A:
[11-216]
-------------
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
-------
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
------------
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
H
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
51.64
54%
-65
- C3 -
4HYP
2
GYRB_ECOLI
D:
[2-205]
----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
-------
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
------
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
51.38
54%
-66
- C3 -
4HYP
2
GYRB_ECOLI
A:
[2-205]
----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
-------
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
------
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
50.89
53%
-57
- C3 -
4DUH
1
GYRB_ECOLI
A:
[15-217]
----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-
D
D
N
S
------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
50.86
54%
-64
- C3 -
4HYP
2
GYRB_ECOLI
C:
[2-205]
----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
-------
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
------
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
50.79
69%
-67
- C3 -
4URN
1
?
A:
[17-223]
--------------
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
K
-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
N
---
E
I
D
V
T
I
N
K
D
G
--
S
I
S
I
E
D
N
G
R
G
M
P
T
G
-
I
H
-
K
-
S
-
G
K
-
P
T
V
E
V
I
F
T
V
L
------------------------
V
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
G
N
I
Y
H
Q
S
F
K
N
G
G
S
P
S
S
--
G
L
V
K
K
G
---
K
--
T
--
K
--
K
-----
T
G
T
K
V
T
F
K
P
D
D
T
I
F
K
A
-
S
T
S
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R
S
G
K
E
R
Q
E
H
---------------
Y
H
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
50.49
53%
-61
- C3 -
4DUH
1
GYRB_ECOLI
B:
[12-217]
-------------
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
-
E
-
G
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
50.26
54%
-60
- C3 -
4KFG
3
GYRB_ECOLI
A:
[2-206]
----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
-------
V
-
S
A
A
E
V
I
M
T
V
L
------------
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
50.04
54%
-64
- C3 -
4HYP
2
GYRB_ECOLI
B:
[2-205]
----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
-------
V
-
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
------
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
49.98
54%
-60
- C3 -
4KFG
3
GYRB_ECOLI
B:
[2-205]
----------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
N
--
S
V
S
V
Q
D
D
G
R
G
I
P
T
---------
G
V
-
S
A
A
E
V
I
M
T
V
L
--------
D
N
S
Y
K
----
V
S
G
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
-
G
V
P
Q
A
--
P
L
A
V
T
G
---
E
--
T
--
E
--
K
-----
T
G
T
M
V
R
F
W
P
S
L
E
T
F
-
T
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
G
K
--
E
D
H
---------------
F
H
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
49.65
59%
-68
- C3 -
4BAE
2
GYRB_MYCSM
B:
[4-203]
----------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
F
A
T
---
R
V
D
V
K
I
H
A
D
G
--
S
V
E
V
R
D
D
G
R
G
I
P
V
E
-
M
H
-
A
-
T
-
G
M
-
P
T
I
D
V
V
M
T
Q
L
-----------------------
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
T
V
L
R
D
G
Y
E
W
F
Q
-
Y
Y
D
R
S
V
P
-
G
--
K
L
K
Q
G
G
---
E
--
T
--
K
--
E
-----
T
G
T
T
I
R
F
W
A
D
P
E
I
F
-
E
-
T
T
D
Y
N
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
E
L
T
D
E
R
D
G
K
--
H
R
V
---------------
F
H
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
49.20
59%
-57
- C3 -
4URO
1
GYRB_STAAU
B:
[26-217]
------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
N
---
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
-
I
Q
E
K
-
M
-
G
R
-
P
A
V
E
V
I
L
T
V
-------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
-
G
V
P
Q
F
--
D
L
K
E
V
G
---
T
--
T
--
D
--
K
-----
T
G
T
V
I
R
F
K
A
D
G
E
I
F
-
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
49.05
59%
-58
- C3 -
4URO
1
GYRB_STAAU
C:
[25-217]
-----------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
N
---
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
-
I
Q
E
K
-
M
-
G
R
-
P
A
V
E
V
I
L
T
--------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
-
G
V
P
Q
F
--
D
L
K
E
V
G
---
T
--
T
--
D
--
K
-----
T
G
T
V
I
R
F
K
A
D
G
E
I
F
-
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
49.01
69%
-58
- C3 -
4URN
2
?
B:
[32-223]
-----------------------------
G
S
T
-
D
-
K
-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
N
---
E
I
D
V
T
I
N
K
D
G
--
S
I
S
I
E
D
N
G
R
G
M
P
T
G
-
I
H
-
K
-
S
-
G
K
-
P
T
V
E
V
I
F
T
V
L
-----------------------
G
V
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
G
N
I
Y
H
Q
S
F
K
N
G
G
S
P
S
S
--
G
L
V
K
K
G
---
K
--
T
--
K
--
K
-----
T
G
T
K
V
T
F
K
P
D
D
T
I
F
K
A
-
S
T
S
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R
S
G
K
E
R
Q
E
H
---------------
Y
H
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
48.15
38%
-71
- C3 -
4HY1
1
?
B:
[8-271]
---------
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
-
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
S
---
K
I
N
I
T
L
Y
E
D
N
--
S
I
E
V
A
D
D
G
R
G
M
P
V
D
-
I
H
-
P
-
E
-
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
-----------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
E
D
G
F
K
T
K
D
LE
I
I
D
N
V
G
---
K
-----
K
--
N
-----
T
G
T
K
I
R
F
W
P
N
K
K
Y
F
-
D
-
D
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
E
I
K
K
E
--
K
L
T
---------------
W
H
F
E
T
G
L
K
G
Y
L
D
H
K
L
-
A
E
T
L
----
P
-
A
E
------------------------
P
S
E
S
I
K
N
S
Y
V
N
L
I
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
48.13
59%
-55
- C3 -
4URM
1
?
D:
[26-217]
------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
N
---
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
-
I
Q
E
K
-
M
-
G
R
-
P
A
V
E
V
I
L
T
V
L
H
A
G
---------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
-
G
V
P
Q
F
--
D
L
K
E
V
G
---
T
--
T
--
D
--
K
-----
T
G
T
V
I
R
F
K
A
D
G
E
I
F
-
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
48.12
59%
-68
- C3 -
4URO
2
GYRB_STAAU
D:
[25-217]
-----------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
N
---
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
-
I
---------
P
A
V
E
V
I
L
T
V
-------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
-
G
V
P
Q
F
--
D
L
K
E
V
G
---
T
--
T
--
D
--
K
-----
T
G
T
V
I
R
F
K
A
D
G
E
I
F
-
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
47.98
46%
-64
* C3 *
3FV5
1
PARE_ECOLI
A:
[1-201]
----------------
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
T
------
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
---
R
V
D
V
I
L
H
A
D
Q
--
S
L
E
V
I
D
D
G
R
G
M
P
V
D
-
I
H
-
P
E
E
-
G
V
-
P
A
V
E
L
I
L
C
R
L
--------------------------
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
Q
D
---
L
Q
V
V
G
---
T
C
G
K
--
R
--
N
-----
T
G
T
S
V
H
F
W
P
D
E
T
F
F
-
D
-
S
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
N
T
--
E
Q
R
---------------
W
C
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
47.56
59%
-59
- C3 -
4URM
2
?
C:
[25-217]
-----------------
L
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
N
---
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
-
I
Q
E
K
-
M
-
G
R
-
P
A
V
E
V
I
L
T
V
L
H
A
G
---------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
-
G
V
P
Q
F
--
D
L
K
E
V
G
---
T
--
T
--
D
--
K
-----
T
G
T
V
I
R
F
K
A
D
G
E
I
F
-
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
47.53
38%
-67
- C3 -
4KQV
2
?
B:
[8-217]
---------
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
---
T
-
N
-
I
-
E
N
P
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
S
---
K
I
N
I
T
L
Y
E
D
N
--
S
I
E
V
A
D
D
G
R
G
M
P
V
D
-
I
H
-
P
-
E
-
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
-------------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
G
N
V
Y
H
I
V
F
E
D
G
F
K
T
K
D
LE
I
I
D
N
V
G
---
K
-----
K
--
N
-----
T
G
T
K
I
R
F
W
P
N
K
K
Y
F
-
D
-
D
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
E
I
K
K
E
--
K
L
T
---------------
W
H
F
E
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
46.86
59%
-59
- C3 -
4URO
1
GYRB_STAAU
A:
[26-217]
------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
N
---
Q
I
E
V
V
I
E
K
D
N
--
W
I
K
V
T
D
N
G
R
G
I
P
V
D
-
I
Q
E
K
-
M
-
G
R
-
P
A
V
E
V
I
L
T
V
------------------------
G
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
-
G
V
P
Q
F
--
D
L
K
E
V
G
---
T
--
T
--
D
--
K
-----
T
G
T
V
I
R
F
K
A
D
G
E
I
F
-
T
E
T
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
43.77
52%
-63
- C3 -
4B6C
3
GYRB_MYCSM
B:
[30-194]
-------------------------------
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
F
A
T
---
R
V
D
V
K
I
H
A
D
G
--
S
V
E
V
R
D
D
G
R
G
I
P
V
E
-
M
H
-
A
-
T
-
G
M
-
P
T
I
D
V
V
M
T
-------------------------
Q
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
T
V
L
R
D
G
Y
E
W
F
Q
-
Y
Y
D
R
S
V
P
-
G
--
K
L
K
Q
G
G
---
E
--
T
--
K
--
E
-----
T
G
T
T
I
R
F
W
A
D
P
E
I
F
-
E
-
T
T
D
Y
N
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
E
L
T
D
E
R
D
G
K
--
H
R
V
---------------
F
H
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Fugue
41.01
45%
-54
- C3 -
1KIJ
2
?
A:
[7-218]
---------
A
I
R
-
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
-
G
--
V
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
---YAT
E
I
L
V
R
L
N
E
--DG
S
L
T
V
E
D
N
G
R
G
I
P
V
D
-
L
M
P
E
-
E
-
G
K
-
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
-----G
A
Y
K
V
S
G
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
--
G
K
H
H
R
I
A
F
S
--
R
G
E
--
V
T
E
P
L
R
---
V
--
V
--
G
--
E
APRG
K
T
G
T
R
V
T
F
K
P
---
D
P
-
E
-
I
F
G
-------
N
-
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
--
K
L
V
---------------
F
Q
D
-
R
Q
H
--
G
K
E
E
V
F
L
D
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Fugue
40.64
45%
-39
- C3 -
1EI1
1
GYRB_ECOLI
A:
[220-391]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
--
H
P
N
I
F
Y
F
---
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
-
F
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------