@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1294: (2016-03-23 )
LSKIPVIVIVGPTAVGKTSLSIELAKKLDGEIISGDSMQVYRGLDIGTAKITPEEMDEIKHYLIDVTDPSEPFTAAKFQTETRKWIETIHQAGKLPIIVGGTGLYIQSVFYDYDFGNVSEDKAYRAELEQLNKTLLWQMLEQQDPESAAQIHENNKRRVIRALEVMHLTGKPFSEYQVHNVLNDTYKPLFLGLDLDRALLYERINQRVNLMFEEGLVTEAKKLYDQHLVDVPAVCGIGYKELFPYFEGKSSLEEAKELIQKNSRHFAKRQLTWFRNRMEIDWIQAGVSTTEAEALNKAETFLSVK
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70.........80........90........100.......110.......120--.-.......---130-----..---.....140.----......150.......160.......170...----------....180...-....190..-.-....200.......210.......220..---..--------.--------.-------.230......------...240.......-----------------250--........260.......270......------.280.-----.....-----.290.......300...-------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LSKI
P
V
I
V
I
VGPTAVGK
T
S
L
S
I
E
L
A
K
KLD
G
E
IISGDS
M
Q
V
Y
R
G
L
DIGTAKI
T
P
E
E
M
D
E
I
K
H
Y
L
I
DVTDPS-EPFTA
A
K
F
Q
T
E
T
R
K
W
I
E
T
I
H
QAGKL
P
I
I
VGGT
G
L
Y
I
Q
S
V
F
YDYDFGNVS
E
D
---
K
-
A
Y
R
A
E
L
E
---
Q
L
N
-----
K
T
---
L
L
W
Q
M
L
E
QQ----D
P
E
S
A
A
Q
I
HEN
N
K
R
R
V
I
R
A
L
E
V
MHLTGKPF
S
E
----------
Y
Q
V
H
N
V
L
NDT-YK
P
L
F
LGLD-
L
-
D
R
A
L
L
Y
E
R
I
N
Q
R
V
N
L
M
F
EEG
L
V
T
E
A
K
K
L
Y
---
D
Q
--------H--------L-------VD--VP
A
V
CG------I
G
Y
K
E
L
F
P
Y
FEGK-----------------
S
-
S
--
L
E
E
A
K
E
L
I
Q
KN
S
R
H
F
A
K
R
Q
L
T
W
F
R
NRM------
E
I
D
W
I
-----QAGVS-----T
T
E
A
E
A
L
N
K
A
E
T
FLSVK-------------------------------------------------------------------------------
6
PsiBlast_PDB
84.44
36%
-86
- C3 -
3EPH
5
MOD5_YEAST
A:
[4-316]
-----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
---
K
-
L
T
R
K
Q
L
D
---
I
L
E
-----
S
T
DPD
V
I
Y
N
T
L
V
K
C
----
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
----------
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
Y
--------
Y
--------
S
-------
Q
N
KF
T
P
E
Q
C
E
NGVWQV
I
G
F
K
E
F
L
P
W
L
T
----------------------V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-
K
M
------
L
I
P
D
I
-----
K
G
D
I
Y
-----
L
L
D
A
T
D
L
S
Q
W
D
T
N
A
S
---------------------------------------------------------------------------------
26
PsiBlast_CBE
83.50
36%
-86
- C3 -
3EPH
4
MOD5_YEAST
B:
[4-316]
-----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
---
K
-
L
T
R
K
Q
L
D
---
I
L
E
-----
S
T
DPD
V
I
Y
N
T
L
V
K
C
----
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
----------
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
Y
--------
Y
--------
S
-------
Q
N
KF
T
P
E
Q
C
E
NGVWQV
I
G
F
K
E
F
L
P
W
L
T
----------------------VK
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-
K
M
------
L
I
P
D
I
-----
K
G
D
I
Y
-----
L
L
D
A
T
D
L
S
Q
W
D
T
N
A
S
---------------------------------------------------------------------------------
24
PsiBlast_CBE
83.25
36%
-87
- C3 -
3EPK
6
MOD5_YEAST
B:
[4-316]
-----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
---
K
-
L
T
R
K
Q
L
D
---
I
L
E
-----
S
T
DPD
V
I
Y
N
T
L
V
K
C
----
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
----------
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
Y
--------
Y
--------
S
-------
Q
N
KF
T
P
E
Q
C
E
NGVWQV
I
G
F
K
E
F
L
P
W
L
T
----------------------VK
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-
K
M
------
L
I
P
D
I
-----
K
G
D
I
Y
-----
L
L
D
A
T
D
L
S
Q
W
D
T
N
A
S
---------------------------------------------------------------------------------
25
PsiBlast_CBE
83.22
36%
-85
- C3 -
3EPJ
3
MOD5_YEAST
B:
[4-316]
-----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
---
K
-
L
T
R
K
Q
L
D
---
I
L
E
-----
S
T
DPD
V
I
Y
N
T
L
V
K
C
----
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
----------
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
Y
--------
Y
--------
S
-------
Q
N
KF
T
P
E
Q
C
E
NGVWQV
I
G
F
K
E
F
L
P
W
L
T
----------------------VK
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-
K
M
------
L
I
P
D
I
-----
K
G
D
I
Y
-----
L
L
D
A
T
D
L
S
Q
W
D
T
N
A
S
---------------------------------------------------------------------------------
8
PsiBlast_PDB
82.91
36%
-85
- C3 -
3EPK
4
MOD5_YEAST
A:
[4-316]
-----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
---
K
-
L
T
R
K
Q
L
D
---
I
L
E
-----
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
----
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
----------
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
Y
--------
Y
--------
S
-------
Q
N
KF
T
P
E
Q
C
E
NGVWQV
I
G
F
K
E
F
L
P
W
L
T
----------------------V
K
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-
K
M
------
L
I
P
D
I
-----
K
G
D
I
Y
-----
L
L
D
A
T
D
L
S
Q
W
D
T
N
A
S
---------------------------------------------------------------------------------
23
PsiBlast_CBE
82.86
36%
-82
- C3 -
3EPL
2
MOD5_YEAST
B:
[4-316]
-----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
---
K
-
L
T
R
K
Q
L
D
---
I
L
E
-----
S
T
DPD
V
I
Y
N
T
L
V
K
C
----
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
----------
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
Y
--------
Y
--------
S
-------
Q
N
KF
T
P
E
Q
C
E
NGVWQV
I
G
F
K
E
F
L
P
W
L
T
----------------------VK
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-
K
M
------
L
I
P
D
I
-----
K
G
D
I
Y
-----
L
L
D
A
T
D
L
S
Q
W
D
T
N
A
S
---------------------------------------------------------------------------------
64
Fugue
82.42
34%
-85
- C3 -
3EPH
6
MOD5_YEAST
A:
[1-409]
--
S
K
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
KLT
R
-
K
Q
L
D
I
L
E
---
S
T
D
-----
P
D
---
V
I
Y
N
T
L
V
K
C
----
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
----------
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
Y
Y
S
QNKFTP
E
--------
Q
-------
C
E
--
N
G
V
W
Q
V
------
I
G
F
K
E
F
L
P
W
L
T
V
--------------------
K
--
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
I
P
D
I
KG
D
I
Y
L
L
D
ATDL
S
Q
W
D
T
-----
N
A
S
Q
R
A
I
A
I
S
N
D
F
I
S
N
R
PIKQERAPKALEELLSKGETTMKKLDDW
T
H
Y
T
CNVCRNADGK
N
V
V
A
I
G
E
K
Y
W
K
I
H
L
G
S
R
R
H
K
S
N
L
K
R
N
T
R
Q
A
D
F
E
K
W
K
I
48
HHSearch
82.27
35%
-89
* C3 *
3EPH
5
MOD5_YEAST
A:
[2-328]
---
K
K
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
--
D
T
K
S
S
---
E
R
K
L
T
R
K
Q
L
D
I
L
E
S
T
D----
P
D
---
V
I
Y
N
T
L
V
K
C
----
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
----------
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
Y
--------
Y
S
QNKFTPE
Q
-------
C
E
--
N
G
V
W
Q
V
------
I
G
F
K
E
F
L
P
W
L
T
--------------------V
K
--
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
K
M
L
I
P
D
I
KG
D
I
Y
L
L
-----
D
A
T
D
L
SQWDT
N
A
S
Q
R
A
I
A
I
S
N
D
F
I
S
---------------------------------------------------------------------------------
7
PsiBlast_PDB
81.67
36%
-83
- C3 -
3EPJ
2
MOD5_YEAST
A:
[4-316]
-----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
---
K
-
L
T
R
K
Q
L
D
---
I
L
E
-----
S
T
DPD
V
I
Y
N
T
L
V
K
C
----
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
----------
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
Y
--------
Y
--------
S
-------
Q
N
KF
T
P
E
Q
C
E
NGVWQV
I
G
F
K
E
F
L
P
W
L
T
----------------------VK
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-
K
M
------
L
I
P
D
I
-----
K
G
D
I
Y
-----
L
L
D
A
T
D
L
S
Q
W
D
T
N
A
S
---------------------------------------------------------------------------------
9
PsiBlast_PDB
81.64
36%
-79
- C3 -
3EPL
1
MOD5_YEAST
A:
[4-316]
-----
V
I
V
I
A
G
T
T
G
V
G
K
S
Q
L
S
I
Q
L
A
Q
K
F
N
G
E
V
I
N
S
D
S
M
Q
V
Y
K
D
I
P
I
I
T
N
K
H
P
L
Q
E
R
E
G
I
P
H
H
V
M
N
H
V
D
W
S
-
E
E
Y
Y
S
H
R
F
E
T
E
C
M
N
A
I
E
D
I
H
R
R
G
K
I
P
I
V
V
G
G
T
H
Y
Y
L
Q
T
L
F
N
K
R
V
D
T
K
S
S
E
R
---
K
-
L
T
R
K
Q
L
D
---
I
L
E
-----
S
T
D
P
D
V
I
Y
N
T
L
V
K
C
----
D
P
D
I
A
T
K
Y
H
P
N
D
Y
R
R
V
Q
R
M
L
E
I
Y
Y
K
T
G
K
K
P
S
E
----------
T
F
N
E
Q
K
I
T
L
K
-
F
D
T
L
F
L
W
L
Y
-
S
-
K
P
E
P
L
F
Q
R
L
D
D
R
V
D
D
M
L
E
R
G
A
L
Q
E
I
K
Q
L
Y
---
E
Y
--------
Y
--------
S
-------
Q
N
KF
T
P
E
Q
C
E
NGVWQV
I
G
F
K
E
F
L
P
W
L
T
----------------------VK
L
E
D
C
I
E
R
M
K
T
R
T
R
Q
Y
A
K
R
Q
V
K
W
I
K
-
K
M
------
L
I
P
D
I
-----
K
G
D
I
Y
-----
L
L
D
A
T
D
L
S
Q
W
D
T
N
A
S
---------------------------------------------------------------------------------
21
PsiBlast_CBE
80.73
36%
-85
- C3 -
3FOZ
2
MIAA_ECOLI
B:
[12-295]
-----
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
-
P
L
P
S
A
D
---
P
-
E
V
R
A
R
I
E
---
Q
Q
A
-----
A
E
---
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
QTSGDALP
Y
Q
V
H
Q
----------
F
A
I
A
P
-
A
-
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
G
D
L
--------
H
----------------
T
D
--
L
P
S
I
R
C
------
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
--
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
W
L
---------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.44
36%
-86
- C3 -
2ZXU
2
MIAA_ECOLI
A:
[12-295]
-----
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
-
P
L
P
S
A
D
---
P
-
E
V
R
A
R
I
E
---
Q
Q
A
-----
A
E
---
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
QTSGDALP
Y
Q
V
H
Q
----------
F
A
I
A
P
-
A
-
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
G
D
L
--------
H
----------------
T
D
--
L
P
S
I
R
C
------
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
--
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
W
L
---------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.77
36%
-84
- C3 -
3FOZ
-
MIAA_ECOLI
A:
[12-295]
-----
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
-
P
L
P
S
A
D
---
P
-
E
V
R
A
R
I
E
---
Q
Q
A
-----
A
E
---
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
QT
S
G
D
A
LP
Y
Q
V
H
Q
----------
F
A
I
A
P
-
A
-
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
G
D
L
--------
H
----------------
T
D
--
L
P
S
I
R
C
------
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
--
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
W
L
---------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.07
36%
-87
- C3 -
2ZM5
-
MIAA_ECOLI
A:
[12-295]
-----
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
-
P
L
P
S
A
D
---
P
-
E
V
R
A
R
I
E
---
Q
Q
A
-----
A
E
---
Q
G
W
E
S
L
H
R
Q
L
Q
E
V
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
QTSGDALP
Y
Q
V
H
Q
----------
F
A
I
A
P
-
A
-
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
RG
D
L
--------
H
----------------
T
D
--
L
P
S
I
R
C
------
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
--
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
W
L
---------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.86
51%
-103
- C3 -
2QGN
1
MIAA_BACHD
A:
[5-286]
-----
L
V
A
I
V
G
P
T
A
V
G
K
T
K
T
S
V
M
L
A
K
R
L
N
G
E
V
I
S
G
D
S
M
Q
V
Y
R
G
M
D
I
G
T
A
K
I
T
A
E
E
M
D
G
V
P
H
H
L
I
D
I
K
D
P
S
-
E
S
F
S
V
A
D
F
Q
D
L
A
T
P
L
I
T
E
I
H
E
R
G
R
L
P
F
L
V
G
G
T
G
L
Y
V
N
A
V
I
H
Q
F
N
L
G
----------------------------------------------------------------------------------------------
E
T
P
S
P
Y
N
L
V
M
I
G
L
T
-
M
-
E
R
D
V
L
Y
D
R
I
N
R
R
V
D
Q
M
V
E
E
G
L
I
D
E
A
K
K
L
Y
---
D
R
--------
G
--------
I
-------
R
D
--
C
Q
S
V
Q
A
------
I
G
Y
K
E
M
Y
D
Y
L
D
G
N
-----------------
V
-
T
--
L
E
E
A
I
D
T
L
K
R
N
S
R
R
Y
A
K
R
Q
L
T
W
F
R
N
K
A
------
N
V
T
W
----------------------------------------------------------------------------------------------------------------
47
HHSearch
78.42
34%
-71
- C3 -
3FOZ
-
MIAA_ECOLI
A:
[8-300]
-
S
L
P
K
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
--
P
L
P
S
A
---
D
-
P
E
V
R
A
R
I
---
E
Q
Q
A
A
E
QG
W
E
---
S
L
H
R
Q
L
Q
E
V
----
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
----------
L
T
Q
T
S
G
D
A
L
P
-
Y
Q
V
H
Q
F
A
I
A
P
A
-
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
---
A
R
--------
G
DL------
H
-------
T
D
--
L
P
S
I
R
C
------
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
--
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
W
L
-----
D
S
E
K
P
-----------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
77.61
36%
-84
- C3 -
2ZXU
2
MIAA_ECOLI
B:
[12-295]
-----
A
I
F
L
M
G
P
T
A
S
G
K
T
A
L
A
I
E
L
R
K
I
L
P
V
E
L
I
S
V
D
S
A
L
I
Y
K
G
M
D
I
G
T
A
K
P
N
A
E
E
L
L
A
A
P
H
R
L
L
D
I
R
D
P
S
-
Q
A
Y
S
A
A
D
F
R
R
D
A
L
A
E
M
A
D
I
T
A
A
G
R
I
P
L
L
V
G
G
T
M
L
Y
F
K
A
L
L
E
G
L
S
-
P
L
P
S
A
D
---
P
-
E
V
R
A
R
I
E
---
Q
Q
A
-----
A
E
---
Q
G
W
E
S
L
H
R
Q
LQEV
D
P
V
A
A
A
R
I
H
P
N
D
P
Q
R
L
S
R
A
L
E
V
F
F
I
S
G
K
T
L
T
E
L
T
QTSGDALP
Y
Q
V
H
Q
----------
F
A
I
A
P
-
A
-
S
R
E
L
L
H
Q
R
I
E
Q
R
F
H
Q
M
L
A
S
G
F
E
A
E
V
R
A
L
F
A
R
G
D
L
--------
H
----------------
T
D
--
L
P
S
I
R
C
------
V
G
Y
R
Q
M
W
S
Y
L
E
G
E
-----------------
I
-
S
--
Y
D
E
M
V
Y
R
G
V
C
A
T
R
Q
L
A
K
R
Q
I
T
W
L
R
G
W
E
------
G
V
H
W
L
---------------------------------------------------------------------------------------------------------------
46
HHSearch
73.50
34%
-79
- C3 -
3CRM
-
MIAA_PSEAE
A:
[3-318]
-
S
L
P
P
A
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
-
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
G
----------------------------------------------------------------------------------------------------
L
P
-
Y
T
V
A
Q
L
A
I
A
-
P
E
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
---
A
R
--------
S
DL------
H
-------
A
G
--
L
P
S
I
R
A
------
V
G
Y
R
Q
V
W
D
Y
L
D
G
K
-----------------
L
-
S
--
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
S
------
H
L
H
W
M
-----
D
S
L
A
G
-----
D
N
L
P
R
A
L
R
Y
L
K
T
------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.21
34%
-84
- C3 -
3CRR
4
MIAA_PSEAE
A:
[6-318]
----
P
A
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
-
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
G
--------------------------------------------------------------------------------------------------
L
P
Y
T
-
V
A
Q
L
A
I
A
P
E
---
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
A
RS
D
L
--------
H
----------------
A
G
--
L
P
S
I
R
A
------
V
G
Y
R
Q
V
W
D
Y
L
D
G
K
-----------------
L
-
S
--
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
S
------
H
L
H
W
M
-----
D
S
L
A
G
-----
D
N
L
P
R
A
L
R
Y
L
K
T
------------------------------------------------------------------------------------
49
HHSearch
72.95
32%
-86
- C3 -
3A8T
2
IPT_HUMLU
A:
[38-294]
-
R
K
E
K
L
L
V
L
M
G
A
T
G
T
G
K
S
R
L
S
I
D
L
A
A
H
F
P
L
E
V
I
N
S
D
K
M
Q
V
Y
K
G
L
D
I
T
T
N
K
I
S
V
P
D
R
G
G
V
P
H
H
L
L
G
E
V
D
P
A
R
G
E
L
T
P
A
D
F
R
S
L
A
G
K
A
V
S
E
I
T
G
R
R
K
L
P
V
L
V
G
G
S
N
S
F
I
H
A
L
L
V
D
R
F
D
--
S
S
-------------------------------------------
G
P
-----------------------------------------------
E
L
R
-
Y
D
C
C
F
L
W
V
D
-
V
-
S
V
K
V
L
T
D
Y
L
A
K
R
V
D
D
M
L
E
L
G
M
F
D
E
L
A
E
F
Y
---
S
P
--------
E
D-------
E
DHDEDSA
T
R
--
T
G
L
R
K
A
------
I
G
V
P
E
F
D
R
Y
F
E
K
F
RPGDVEGEDPGR
D
R
V
R
R
G
-
A
--
F
E
E
A
V
R
A
I
K
E
N
T
C
H
L
A
K
R
Q
I
G
K
I
L
R
L
K
------
G
A
G
W
----------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.32
34%
-83
- C3 -
3CRQ
2
MIAA_PSEAE
A:
[6-318]
----
P
A
I
F
L
M
G
P
T
A
A
G
K
T
D
L
A
M
A
L
A
D
A
L
P
C
E
L
I
S
V
D
S
A
L
I
Y
R
G
M
D
I
G
T
A
K
P
S
R
E
L
L
A
R
Y
P
H
R
L
I
D
I
R
D
P
A
-
E
S
Y
S
A
A
E
F
R
A
D
A
L
A
A
M
A
K
A
T
A
R
G
R
I
P
L
L
V
G
G
T
M
L
Y
Y
K
A
L
L
E
G
--------------------------------------------------------------------------------------------------
L
P
Y
T
-
V
A
Q
L
A
I
A
P
E
---
Q
R
Q
V
L
H
A
R
I
A
Q
R
F
R
Q
M
L
E
Q
G
F
I
A
E
V
E
A
L
H
A
RS
D
L
--------
H
----------------
A
G
--
L
P
S
I
R
A
------
V
G
Y
R
Q
V
W
D
Y
L
D
G
K
-----------------
L
-
S
--
Y
A
E
M
T
E
R
G
I
I
A
T
R
Q
L
A
K
R
Q
F
T
W
L
R
S
W
S
------
H
L
H
W
M
-----
D
S
L
A
G
-----
D
N
L
P
R
A
L
R
Y
L
K
T
------------------------------------------------------------------------------------