@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1297: (2016-03-23 )
MNNIQAMRKKVEVQIADLQNETDEIAEFNQAKVLDAFQENKVSDFHFHPSTGYGYDDEGRDTLEHVYATVFKTEAALVRPQIISGTHAISTVLFGILRPDDELLYITGQPYDTLEEIVGMRNQGQGSLKDFHIGYSSVPLLENGDVDFPLIAEKMTRKTKMIGIQRSRGYADRPSFTIDKIKEMIIFVKNINPEVIVFVDNCYGEFAEYLEPTEVGADIIAGSLIKNPGGGLAKTGGYIAGKEALIDLCGYRLTTPGIGREAGASLYSLLEMYQGFFLAPHVTAQAIKGARFTAAMLAEFGVVADPTWDAPRTDLIQSISFHNKEKMVAFAQAIQAASPVNAHVLPIGAYMPGYEDDVIMAAGTFIQGASLELTADGPIREPYQLYVQGGLTYEHVKIAVTRAIQKTL
Atome Classification :
(20 SA)
.........10....-------....20........30........40........50......---.---.---60........70........80.....---...90........100......-.110..-......120.-..-....130.......140.......150....-.--..160.......170.......180.......190.--.......200.......210......----.220......-.230.......240-..-....------.250---------------------.-..-......260.......270.......-280.......290....--...---300--.-----.---.-.--.------.------.------.--------310----.-------.------.......320.-.-.....330---........340.......350.......360.......370.......380.......390.......400......--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
N
I
Q
A
M
R
K
K
V
E
V
Q
I
-------ADLQNE
T
D
E
I
A
E
F
N
Q
A
K
V
L
D
A
F
Q
ENKVS
D
F
HFHPSTGYGYDD---E---G---
R
D
T
L
E
H
V
Y
A
T
V
F
KTEA
A
L
VRPQIIS
G
T
---
H
A
I
S
T
V
L
F
G
I
LRPDD
E
L
L
Y
I
TG-Q
P
-
Y
D
T
-
L
E
E
I
VGMRNQ-GQ-GSL
K
D
F
HIGYSSVPLLENGDVD
F
P
L
I
A
E
K
M
T-R--KT
K
M
I
G
I
QRSRGYADRPSF
T
I
D
K
I
K
E
M
I
I
F
V
KN-IN--P
E
V
I
V
F
VD
N
C
Y
G
E
F
A
E
YL
E
P
T
EV
G
A
D
----
I
I
A
G
S
L
IKNP-GGGLAKTGGYIA
G
K
-
E
A
-
L
I
D
L------CG-----------------------Y-RL-TTPGI
G
R
E
A
G
A
S
L
Y
S
L
L
E
M
Y
Q
G
FFLA-
P
H
V
T
A
Q
A
IKG
A
R
F
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A
M
--
L
A
E---F-G--V-----V---A-D--P------T------W------D--------A------
P
-------
R
------
T
D
L
I
Q
S
I
SFH
N
-
K
-
E
K
M
V
A
F
A
----
Q
A
I
QAASPVN
A
H
V
L
P
IGAYMPGYED
D
V
I
M
AAG
T
F
IQG
A
S
L
E
L
TADGPIRE
P
Y
Q
L
Y
V
QGG
L
T
Y
E
H
V
K
I
A
V
T
R
A
I
Q
KTL--
1
PsiBlast_PDB
98.95
92%
-100
- C1 -
3JZL
3
?
A:
[5-409]
---
I
Q
A
I
R
K
K
V
E
T
Q
I
-------
D
D
L
Q
N
K
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D
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A
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F
N
Q
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Y
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---
E
---
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---
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L
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Y
A
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F
K
T
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A
A
L
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P
Q
I
I
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G
T
---
H
A
I
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L
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L
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P
D
D
E
L
L
Y
I
T
G
-
Q
P
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V
G
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K
Q
-
G
Q
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K
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--
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G
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Q
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P
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A
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----
I
I
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L
I
K
N
P
-
G
G
G
L
A
K
T
G
G
Y
I
A
G
K
-
E
A
-
L
V
D
L
------
C
G
-----------------------
Y
-
R
L
-
T
T
P
G
I
G
R
E
A
G
A
S
L
Y
S
L
L
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P
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------
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I
Q
S
V
S
F
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N
-
K
-
E
K
M
V
A
F
A
----
Q
A
I
Q
A
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P
V
N
A
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V
L
P
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A
Y
M
P
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D
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A
A
G
T
F
I
Q
G
A
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L
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L
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P
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R
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P
Y
Q
L
Y
V
Q
G
G
L
T
Y
E
H
I
K
I
A
V
T
R
A
I
Q
K
I
V
--
27
HHSearch
98.30
94%
-96
- C1 -
3JZL
3
?
A:
[5-408]
---
I
Q
A
I
R
K
K
V
E
T
Q
I
-------
D
D
L
Q
N
K
T
D
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I
A
E
F
N
Q
A
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V
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D
A
F
Q
E
N
K
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F
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P
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G
Y
G
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D
D
---
E
---
G
---
R
D
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L
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R
V
Y
A
T
V
F
K
T
E
A
A
L
V
R
P
Q
I
I
S
G
T
---
H
A
I
S
T
V
L
F
G
I
L
R
P
D
D
E
L
L
Y
-
I
T
G
Q
P
-
Y
D
T
-
L
E
E
I
V
G
I
R
K
Q
-
G
Q
-
G
S
L
K
D
F
H
I
G
Y
S
S
V
P
L
L
E
N
G
D
V
D
F
P
R
I
A
K
K
M
T
-
P
--
K
T
K
M
I
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I
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R
S
R
G
Y
A
D
R
P
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F
T
I
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K
I
K
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M
I
V
F
V
K
N
-
I
N
--
P
E
V
I
V
F
V
D
N
C
Y
G
E
F
V
E
Y
Q
E
P
P
E
V
G
A
D
----
I
I
A
G
S
L
I
K
N
P
-
G
G
G
L
A
K
T
G
G
Y
I
A
G
K
-
E
A
-
L
V
D
L
------
C
G
-----------------------
Y
-
R
L
-
T
T
P
G
I
G
R
E
A
G
A
S
L
Y
S
L
L
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M
Y
Q
G
F
F
L
A
-
P
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V
T
A
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A
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K
G
A
R
F
T
A
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--
L
A
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---
F
-
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--
V
-----
E
---
A
-
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--
P
------
V
------
W
------
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--------
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------
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-------
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------
T
D
L
I
Q
S
V
S
F
H
N
-
K
-
E
K
M
V
A
F
A
----
Q
A
I
Q
A
A
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P
V
N
A
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V
L
P
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G
A
Y
M
P
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Y
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D
D
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A
A
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F
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Q
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A
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L
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L
T
A
D
G
P
I
R
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P
Y
Q
L
Y
V
Q
G
G
L
T
Y
E
H
I
K
I
A
V
T
R
A
I
Q
K
I
---
2
PsiBlast_PDB
96.02
85%
-99
- C1 -
3FD0
24
?
A:
[5-409]
---
I
Q
T
I
R
K
K
V
E
Q
Q
I
-------
T
S
L
Q
N
E
T
D
E
I
A
E
F
N
Q
A
K
V
L
D
A
F
Q
E
N
K
V
S
D
F
H
F
N
P
S
T
G
Y
G
Y
D
D
---
E
---
G
---
R
D
T
L
E
R
V
Y
A
S
V
F
K
T
E
A
A
L
V
R
P
Q
I
I
S
G
T
---
H
A
I
S
T
V
L
F
G
I
L
R
P
G
D
E
L
L
Y
I
T
G
-
E
P
-
Y
D
T
-
L
E
E
I
V
G
I
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S
E
-
G
Q
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G
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D
F
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Y
D
A
V
P
L
L
P
N
G
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I
D
Y
P
A
V
S
K
K
I
S
-
A
--
N
T
K
M
I
G
I
Q
R
S
R
G
Y
A
D
R
P
S
F
T
I
E
K
I
K
E
M
V
T
F
V
K
N
-
I
N
--
P
N
I
I
V
F
V
D
N
C
Y
G
E
F
V
E
R
I
E
P
T
E
V
G
A
D
----
I
I
A
G
S
L
I
K
N
P
-
G
G
G
L
A
K
T
G
G
Y
I
A
G
R
-
N
T
-
L
V
D
L
------
C
G
-----------------------
Y
-
R
L
-
T
T
P
G
I
G
R
E
A
G
A
S
L
Y
S
L
L
E
M
Y
Q
G
F
F
L
A
-
P
H
V
T
A
Q
A
I
K
G
A
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F
T
A
A
M
--
L
A
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---
F
-
G
--
V
-----
E
---
A
-
D
--
P
------
L
------
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------
D
--------
A
------
K
-------
R
------
T
D
L
I
Q
S
V
S
F
H
S
-
K
-
D
K
M
I
A
F
A
----
Q
A
I
Q
A
A
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P
V
N
A
H
V
L
P
I
G
A
Y
M
P
G
Y
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D
D
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M
A
A
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T
F
I
Q
G
A
S
L
E
L
T
A
D
G
P
I
R
E
P
Y
Q
L
Y
V
Q
G
G
L
T
Y
E
H
V
K
I
A
V
T
R
A
I
E
N
S
L
--
26
HHSearch
85.19
50%
-91
- C1 -
3HVY
7
?
A:
[21-426]
----
L
E
L
Y
E
R
A
L
N
D
V
-------
E
K
E
F
K
Y
Y
D
E
I
R
E
Y
N
Q
L
K
V
L
K
A
F
Q
E
E
R
I
S
E
S
H
F
T
N
S
S
G
Y
G
Y
N
D
---
I
---
G
---
R
D
S
L
D
R
V
Y
A
N
I
F
N
T
E
S
A
F
V
R
P
H
F
V
N
G
T
---
H
A
I
G
A
A
L
F
G
N
L
R
P
N
D
T
M
M
S
-
I
C
-
G
M
P
Y
D
T
-
L
H
D
I
I
G
M
D
D
S
K
K
V
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G
S
L
R
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Y
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K
Y
K
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D
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G
K
V
D
I
N
T
V
K
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E
L
K
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K
D
D
S
I
K
L
I
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I
Q
R
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T
G
Y
G
W
R
K
S
L
R
I
A
E
I
A
E
I
I
K
S
I
R
E
-
V
N
--
E
N
V
I
V
F
V
D
N
C
Y
G
E
F
V
E
E
K
E
P
T
D
V
G
A
D
----
I
I
A
G
S
L
I
K
N
I
-
G
G
G
I
A
T
T
G
G
Y
I
A
G
K
-
E
E
-
Y
V
T
Q
------
A
T
-----------------------
F
-
R
V
-
T
V
P
G
I
G
G
E
C
G
S
T
F
G
V
M
R
S
L
Y
E
G
L
F
M
A
-
P
H
V
T
I
E
A
V
K
G
A
V
F
C
A
R
I
--
M
E
L
---
A
-
G
--
F
-----
D
---
V
-
L
--
P
------
K
------
Y
------
N
--------
D
------
K
-------
R
------
T
D
I
I
Q
A
I
K
F
N
D
-
E
-
K
K
L
I
D
F
I
----
K
G
I
Q
T
A
S
P
V
D
S
F
V
Q
C
----------
K
V
I
M
A
A
G
T
F
V
Q
G
A
S
I
E
L
S
A
D
A
P
I
R
E
P
Y
I
G
Y
L
Q
G
G
L
T
F
D
H
A
K
L
G
V
L
I
A
L
S
K
L
I
--
4
PsiBlast_PDB
84.62
51%
-96
- C1 -
3HVY
5
?
D:
[39-426]
-----------------------------
D
E
I
R
E
Y
N
Q
L
K
V
L
K
A
F
Q
E
E
R
I
S
E
S
H
F
T
N
S
S
G
Y
G
Y
N
D
---
I
---
G
---
R
D
S
L
D
R
V
Y
A
N
I
F
N
T
E
S
A
F
V
R
P
H
F
V
N
G
T
---
H
A
I
G
A
A
L
F
G
N
L
R
P
N
D
T
M
M
S
I
C
G
-
M
P
-
Y
D
T
-
L
H
D
I
I
G
M
D
D
S
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K
K
V
G
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L
R
E
Y
G
V
K
Y
K
M
V
D
-
L
K
D
G
K
V
D
I
N
T
V
K
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L
K
-
K
DD
S
I
K
L
I
H
I
Q
R
S
T
G
Y
G
W
R
K
S
L
R
I
A
E
I
A
E
I
I
K
S
I
R
E
-
V
N
--
E
N
V
I
V
F
V
D
N
C
Y
G
E
F
V
E
E
K
E
P
T
D
V
G
A
D
----
I
I
A
G
S
L
I
K
N
I
-
G
G
G
I
A
T
T
G
G
Y
I
A
G
K
-
E
E
-
Y
V
T
Q
------
A
T
-----------------------
F
-
R
V
-
T
V
P
G
I
G
G
E
C
G
S
T
F
G
V
M
R
S
L
Y
E
G
L
F
M
A
-
P
H
V
T
I
E
A
V
K
G
A
V
F
C
A
R
I
ME
L
A
G
---
F
-
D
--
V
-----
L
--------
P
------
K
------
Y
------
N
--------
D
------
K
-------
R
------
T
D
I
I
Q
A
I
K
F
N
D
-
E
-
K
K
L
I
D
F
I
----
K
G
I
Q
T
A
S
P
V
D
S
F
V
----
Q
C
E
A
W
Y
E
D
K
V
I
M
A
A
G
T
F
V
Q
G
A
S
I
E
L
S
A
D
A
P
I
R
E
P
Y
I
G
Y
L
Q
G
G
L
T
F
D
H
A
K
L
G
V
L
I
A
L
S
K
L
I
--
28
HHSearch
83.04
49%
-92
- C1 -
3I16
10
?
A:
[19-425]
---
V
L
K
L
Y
E
T
A
M
N
D
I
-------
Q
N
Q
F
K
I
L
D
D
I
R
E
F
N
Q
L
K
V
L
N
A
F
Q
E
E
R
I
S
E
A
H
F
T
N
S
S
G
Y
G
Y
G
D
---
I
---
G
---
R
D
S
L
D
A
V
Y
A
R
V
F
N
T
E
S
A
L
V
R
P
H
F
V
N
G
T
---
H
A
L
G
A
A
L
F
G
N
L
R
P
G
N
T
M
L
S
V
C
G
-
E
P
-
Y
D
T
-
L
H
D
V
I
G
I
T
E
N
S
N
M
-
G
S
L
K
E
F
G
I
N
Y
K
Q
V
D
L
K
E
D
G
K
P
N
L
E
E
I
E
K
V
L
K
-
E
D
E
S
I
T
L
V
H
I
Q
R
S
T
G
Y
G
W
R
R
A
L
L
I
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D
I
K
S
I
V
D
C
V
K
N
-
I
R
--
K
D
I
I
C
F
V
D
N
C
Y
G
E
F
M
D
T
K
E
P
T
D
V
G
A
D
----
L
I
A
G
S
L
I
K
N
I
-
G
G
G
I
A
P
T
G
G
Y
L
A
G
T
-
K
D
-
C
I
E
K
------
T
S
-----------------------
Y
-
R
L
-
T
V
P
G
I
G
G
E
C
G
S
T
F
G
V
V
R
S
M
Y
Q
G
L
F
L
A
-
P
H
I
S
M
E
A
L
K
G
A
I
L
C
S
R
I
--
M
E
L
---
A
-
G
--
F
-----
E
---
V
-
M
--
P
------
K
------
Y
------
D
--------
E
------
K
-------
R
------
S
D
I
I
Q
S
I
K
F
N
D
-
K
-
D
K
L
I
E
F
C
----
K
G
I
Q
T
G
S
P
I
D
S
F
V
S
C
E
P
W
D
M
---
T
D
Q
V
I
M
A
A
G
A
F
I
Q
G
S
S
I
E
L
S
A
D
A
P
I
R
E
P
Y
I
A
Y
L
Q
G
G
L
T
F
D
H
A
K
I
G
I
L
I
A
L
S
R
I
---
3
PsiBlast_PDB
74.79
66%
-44
- C1 -
3HT4
-
?
A:
[10-415]
--
K
I
A
P
I
V
K
E
V
E
S
Q
I
-------
T
E
V
H
K
R
A
D
E
V
I
E
S
N
Q
F
R
V
L
E
S
F
G
K
H
K
I
S
D
S
H
F
I
P
T
T
G
Y
G
Y
D
D
---
I
---
G
---
R
D
T
L
E
K
V
Y
A
D
V
F
G
A
E
A
G
L
V
R
P
Q
I
I
S
G
T
---
H
A
I
S
T
A
L
F
G
I
L
R
P
G
D
E
L
L
Y
I
T
G
-
K
P
-
Y
D
T
-
L
E
E
I
V
G
V
R
G
K
-
G
V
-
G
S
F
K
E
Y
N
I
G
Y
N
A
V
P
L
T
E
G
G
L
V
D
F
E
A
V
A
A
A
I
H
-
S
--
N
T
K
M
I
G
I
Q
R
S
K
G
Y
A
T
R
P
S
F
T
I
S
Q
I
K
E
M
I
A
F
V
K
E
-
I
K
--
P
D
V
V
V
F
V
D
N
C
Y
G
E
F
I
E
E
Q
E
P
C
H
V
G
A
D
----
L
M
A
G
S
L
I
K
N
P
-
G
G
G
I
V
K
T
G
G
Y
I
V
G
K
-
E
Q
-
Y
V
E
A
------
C
A
-----------------------
Y
-
R
L
-
T
S
P
G
I
G
A
E
A
G
A
S
L
Y
S
L
Q
E
M
Y
Q
G
F
F
L
A
-
P
H
V
A
G
Q
A
L
K
G
A
I
F
T
A
A
F
--
L
E
K
---
L
-
G
--
M
-----
N
---
T
-
S
--
P
------
A
------
W
------
N
--------
A
------
P
-------
R
------
T
D
L
I
Q
S
V
Q
F
D
D
-
K
-
D
R
M
I
A
F
C
----
Q
A
I
Q
Y
A
S
P
I
N
S
H
F
T
P
Y
A
N
Y
M
P
G
Y
E
D
D
V
I
M
A
A
G
T
F
I
Q
G
A
S
I
E
L
S
A
D
G
P
I
R
P
P
Y
V
A
Y
V
Q
G
G
L
T
Y
S
H
V
K
I
A
I
C
S
A
I
D
E
L
I
--
29
HHSearch
73.90
68%
-39
- C1 -
3HT4
-
?
A:
[13-415]
-----
P
I
V
K
E
V
E
S
Q
I
-------
T
E
V
H
K
R
A
D
E
V
I
E
S
N
Q
F
R
V
L
E
S
F
G
K
H
K
I
S
D
S
H
F
I
P
T
T
G
Y
G
Y
D
D
---
I
---
G
---
R
D
T
L
E
K
V
Y
A
D
V
F
G
A
E
A
G
L
V
R
P
Q
I
I
S
G
T
---
H
A
I
S
T
A
L
F
G
I
L
R
P
G
D
E
L
L
Y
-
I
T
G
K
P
-
Y
D
T
-
L
E
E
I
V
G
V
R
G
K
-
G
V
-
G
S
F
K
E
Y
N
I
G
Y
N
A
V
P
L
T
E
G
G
L
V
D
F
E
A
V
A
A
A
I
H
-
S
--
N
T
K
M
I
G
I
Q
R
S
K
G
Y
A
T
R
P
S
F
T
I
S
Q
I
K
E
M
I
A
F
V
K
E
-
I
K
--
P
D
V
V
V
F
V
D
N
C
Y
G
E
F
I
E
E
Q
E
P
C
H
V
G
A
D
----
L
M
A
G
S
L
I
K
N
P
-
G
G
G
I
V
K
T
G
G
Y
I
V
G
K
-
E
Q
-
Y
V
E
A
------
C
A
-----------------------
Y
-
R
L
-
T
S
P
G
I
G
A
E
A
G
A
S
L
Y
S
L
Q
E
M
Y
Q
G
F
F
L
A
-
P
H
V
A
G
Q
A
L
K
G
A
I
F
T
A
A
F
--
L
E
K
---
L
-
G
--
M
-----
N
---
T
-
S
--
P
------
A
------
W
------
N
--------
A
------
P
-------
R
------
T
D
L
I
Q
S
V
Q
F
D
D
-
K
-
D
R
M
I
A
F
C
----
Q
A
I
Q
Y
A
S
P
I
N
S
H
F
T
P
Y
A
N
Y
M
P
G
Y
E
D
D
V
I
M
A
A
G
T
F
I
Q
G
A
S
I
E
L
S
A
D
G
P
I
R
P
P
Y
V
A
Y
V
Q
G
G
L
T
Y
S
H
V
K
I
A
I
C
S
A
I
D
E
L
I
--
32
HHSearch
62.26
17%
-92
- C1 -
1PFF
18
?
A:
[2-330]
-----------------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
---
T
A
S
G
M
---
G
A
I
A
A
S
V
W
T
F
L
K
A
G
D
H
L
I
S
-
D
D
-
C
L
-
Y
G
C
-
T
H
A
L
F
-------
E
-
H
Q
L
R
K
F
G
V
E
V
D
F
I
D
M
A
-----
V
P
G
N
I
E
K
H
L
K
-
P
--
N
T
R
I
V
Y
F
E
T
P
----
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
Q
K
----
D
I
L
V
I
V
D
N
T
F
A
S
P
I
L
-
T
N
P
L
D
L
G
V
D
----
I
V
V
H
S
A
T
K
Y
I
-
N
G
H
T
D
V
V
A
G
L
V
C
S
R
-
A
D
-
I
I
A
K
------
V
K
-----------------------
S
-
Q
G
-
I
K
D
I
T
G
--
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
-
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
--
L
H
E
---
H
K
A
--
V
-----
K
---
K
-
V
Y
Y
P
------
G
------
L
------
P
--------
D
HPG
H
E
I
A
-------
K
K
Q
MKM-
F
G
S
M
I
A
F
D
V
D
G
-
L
-
E
K
A
K
K
V
L
----
D
N
C
H
------
V
V
S
L
--
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V
---
30
HHSearch
58.48
16%
-83
* C1 *
1QGN
2
?
A:
[105-444]
----------------------------------------------------------
S
F
E
Y
G
R
YGN
P
---
T
---
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
---
M
A
S
G
M
---
C
A
S
T
V
M
L
L
A
L
V
P
A
G
G
H
I
V
T
-
T
T
-
D
C
-
Y
R
K
-
T
R
I
F
I
-------
E
-
T
I
L
P
K
M
G
I
T
A
T
V
I
D
P
A
-----
D
V
G
A
L
E
L
A
L
N
Q
K
--
K
V
N
L
F
F
T
E
S
P
----
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
-
K
----
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
-
Q
K
A
L
A
L
G
A
D
----
L
V
L
H
S
A
T
K
F
L
-
G
G
H
N
D
V
L
A
G
C
I
S
G
P
-
L
K
-
L
V
S
E
------
I
R
-----------------------
N
-
L
H
-
H
I
--
L
G
G
--
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
-
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
--
L
E
A
---
H
P
K
--
V
-----
R
H
--
V
Y
Y
--
P
------
G
LQSHPE
H
------
H
--------
I
------
A
K
K
QMT--
G
------
F
G
G
A
V
S
F
E
V
D
G
-
D
L
L
T
T
A
K
F
V
----
D
A
L
K
I
P
Y
I
A
P
S
--------
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
S
----
36
HHSearch
57.00
19%
-85
- C1 -
2CTZ
1
?
A:
[58-420]
-------------------------------------------------------------------
P
---
T
---
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
---
T
A
S
G
H
---
A
A
Q
F
L
A
L
T
T
L
A
Q
A
G
D
N
I
V
S
-
T
P
-
N
L
-
Y
G
G
-
T
F
N
Q
F
-------
K
-
V
T
L
K
R
L
G
I
E
V
R
F
T
S
R
E
----
E
R
P
E
E
F
L
A
L
T
D
-
E
--
K
T
R
A
W
W
V
E
S
I
----
G
N
P
A
L
N
I
P
D
L
E
A
L
A
Q
A
A
R
E
-
K
----
G
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
----
L
V
T
H
S
L
T
K
W
V
-
G
G
H
G
A
V
I
A
G
A
I
V
D
G
-
G
N
-
F
P
W
E
GGRYPL
L
T
EPQPGYHGLRLTEAFGEL
A
F
I
V
K
A
R
V
D
-
G
L
R
D
Q
G
Q
--
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
-
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
--
L
L
E
---
Q
P
Q
--
V
-----
A
W
--
V
N
Y
--
P
------
G
------
L
PHHPH
H
D
--------
R
------
A
-------
Q
K
Y
FKGK
P
G
A
V
L
T
F
G
L
K
G
G
Y
-
E
A
A
K
R
F
I
----
S
R
L
K
L
I
S
H
L
A
N
--------
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
------
34
HHSearch
54.68
20%
-87
- C1 -
1E5E
5
?
A:
[52-332]
---------------------------------------------------------
S
G
Y
I
Y
T
R
---
L
---
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
---
T
S
S
G
M
---
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
-
D
E
-
C
L
-
Y
G
C
-
T
H
A
L
F
-------
E
-
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
T
A
-----
I
P
G
E
V
K
K
H
M
K
-
P
--
N
T
K
I
V
Y
F
E
T
P
----
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
E
----
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
----
V
V
V
H
S
A
T
K
Y
I
-
N
G
H
T
D
V
V
A
G
L
I
C
G
K
-
A
D
-
L
L
Q
Q
------
I
R
-----------------------
M
-
V
G
-
I
K
D
I
T
G
S
--
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
-
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
--
L
K
S
---
H
-
P
A-
V
-----
E
K
--
V
Y
Y
--
P
------
G
FEDHEG
H
------
D
--------
I
A
K
K
Q
M
-
R
-------
M
------
Y
G
S
M
I
T
F
I
L
K
S
-
G
F
E
G
A
K
K
L
L
----
D
N
L
K
L
--------------------------------------------------------------------------
54
Fugue
54.33
15%
-73
- C1 -
1FG7
1
HIS8_ECOLI
A:
[3-356]
T
V
T
I
T
D
L
A
R
E
N
V
R
N
L
-------
T
P
Y
Q
S
A
R
R
L
--
G
G
N
G
D
V
W
L
N
A
N
E
Y
P
T
A
V
E
F
Q
L
T
Q
Q
T
L
N
R
Y
P
E
---
C
---
Q
---
P
K
A
V
I
E
N
Y
A
Q
Y
A
G
V
K
P
E
Q
V
--
L
V
S
R
G
A
---
D
E
G
I
E
L
L
I
R
A
F
C
E
P
G
K
D
A
I
L
Y
C
-
P
P
-
T
Y
G
M
Y
S
V
S
A
E
T
I
G
------------
V
E
C
R
T
V
P
T
L
D
N
W
Q
L
D
L
Q
G
I
S
D
K
L
D
----
G
V
K
V
V
Y
V
C
S
P
N
----
N
P
T
G
Q
L
I
N
P
Q
D
F
R
T
L
L
E
L
-
T
R
--
G
K
A
I
V
V
A
D
E
A
Y
I
E
F
C
P
Q
A
S
L
A
G
W
L
A
E
YPH
L
A
I
L
R
T
L
S
K
A
F
-
A
L
A
G
L
R
C
G
F
T
L
A
N
E
-
E
V
-
I
N
L
L
--------
M
----------------------
K
-
V
I
-
A
P
Y
P
L
S
T
P
V
A
D
I
A
A
Q
A
L
S
--
P
Q
G
I
V
A
M
R
E
R
V
A
Q
I
I
A
E
R
E
Y
L
I
A
A
--
L
K
E
---
I
-
P
--
C
-----
V
---
E
-
Q
--
V
------
F
-----------------------------
D
-------
S
------
E
T
N
Y
I
L
A
R
F
K
A
---------
S
----
S
A
V
F
K
S
L
W
D
Q
G
I
I
L
R
D
Q
N
K
Q
P
S
L
S
G
C
L
R
I
T
V
G
T
----------------------------
R
E
E
S
Q
R
V
I
D
A
L
R
A
E
Q
V
--
53
Fugue
54.31
15%
-70
- C1 -
1IJI
1
HIS8_ECOLI
A:
[3-356]
T
V
T
I
T
D
L
A
R
E
N
V
R
N
L
-------
T
P
Y
Q
S
A
R
R
L
--
G
G
N
G
D
V
W
L
N
A
N
E
Y
P
T
A
V
E
F
Q
L
T
Q
Q
T
L
N
R
Y
P
E
---
C
---
Q
---
P
K
A
V
I
E
N
Y
A
Q
Y
A
G
V
K
----
P
E
Q
V
L
V
S
R
G
A
D
E
G
I
E
L
L
I
R
A
F
C
E
P
G
K
D
A
I
L
Y
C
P
-
P
T
-
Y
G
M
-
Y
S
V
S
A
E
T
I
G
------------
V
E
C
R
T
V
P
T
L
D
N
W
Q
L
D
L
Q
G
I
S
D
K
L
D
----
G
V
K
V
V
Y
V
C
S
P
----
N
N
P
T
G
Q
L
I
N
P
Q
D
F
R
T
L
L
E
L
-
T
R
--
G
K
A
I
V
V
A
D
E
A
Y
I
E
F
C
P
Q
A
S
L
A
G
W
L
A
E
YPH
L
A
I
L
R
T
L
S
K
A
F
-
A
L
A
G
L
R
C
-
G
F
T
L
A
N
-
E
E
-
V
I
N
L
------
L
M
-----------------------
K
-
V
I
-
A
P
Y
P
L
S
T
P
V
A
D
I
A
A
Q
A
L
S
-
P
Q
G
I
V
A
M
-
R
E
R
V
A
Q
I
I
A
E
R
E
Y
L
I
A
A
--
L
K
E
---
I
-
P
--
C
-----
V
---
E
-
Q
--
V
------
F
-----------------------------
D
-------
S
------
E
T
N
Y
I
L
A
R
F
K
A
-
S
-
S
A
V
F
K
S
L
----
W
D
-------
Q
G
I
I
L
R
D
Q
N
K
Q
P
S
L
S
G
C
L
R
I
T
V
G
T
----------------------------
R
E
E
S
Q
R
V
I
D
A
L
R
A
E
Q
V
--
35
HHSearch
54.26
22%
-90
- C1 -
2RFV
1
?
A:
[56-333]
-----------------------------------------------------------
Y
I
Y
T
R
---
L
GN
P
T
---
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
---
T
A
S
G
I
---
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
-
A
S
-
A
I
-
Y
G
C
-
T
H
A
F
L
-------
S
-
H
S
M
P
K
F
G
I
N
V
R
F
V
D
A
A
-----
K
P
E
E
I
R
A
A
M
R
-
P
--
E
T
K
V
V
Y
I
E
T
P
----
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
----
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
----
I
V
V
H
S
V
T
K
Y
I
-
N
G
H
G
D
V
I
G
G
I
I
V
G
K
-
Q
E
-
F
I
D
Q
------
A
R
-----------------------
F
-
V
G
-
L
K
D
I
T
G
G
--
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
-
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
--
L
E
G
---
H
P
S
--
I
-----
T
R
V
-
Y
-
Y
--
P
GLSSHP
Q
------
Y
------
E
L
G
Q
R
----
Q
------
M
-------
S
L-----
P
G
G
I
I
S
F
E
I
A
G
-
G
L
E
A
G
R
R
M
I
----
N
S
V
E
L
--------------------------------------------------------------------------
49
Fugue
52.66
15%
-62
- C1 -
1CS1
-
METB_ECOLI
A:
[3-386]
-------
R
K
Q
A
T
I
A
V
RSGLNDD
E
Q
Y
--
G
C
V
V
P
P
I
H
L
S
S
T
Y
N
F
T
G
F
--------
N
E
P
R
-
A
H
D
Y
S
R
---
R
---
G
---
N
P
T
R
D
V
V
Q
R
A
L
A
E
L
E
G
G
A
G
A
V
L
T
N
T
G
M
---
S
A
I
H
L
V
T
T
V
F
L
K
P
G
D
L
L
V
A
P
H
D
-
C
Y
-
G
G
S
-
Y
R
L
F
D
S
L
---------
A
K
R
G
C
Y
R
V
L
F
V
D
Q
G
D
E
Q
A
L
R
A
A
L
A
-
E
K
-------
P
K
L
V
L
V
E
----
S
P
S
N
P
L
L
R
V
V
D
I
A
K
I
C
H
L
A
R
E
-
V
----
G
A
V
S
V
V
D
N
T
F
L
S
P
A
-
L
Q
N
P
L
A
L
G
A
D
----
L
V
L
H
S
C
T
K
Y
L
-
N
G
H
S
D
V
V
A
G
V
V
I
A
K
D
P
D
-
V
V
T
E
------
L
A
-----------------------
W
-
W
A
-
N
N
I
G
----
V
T
G
G
A
F
D
S
Y
L
L
L
R
G
L
R
T
L
-
V
P
R
M
E
L
A
Q
R
N
A
Q
A
I
V
K
Y
--
L
Q
T
QPL
V
-
K
--
K
-----
L
---
Y
-
H
--
P
------
S
------
L
------
P
--------
E
------
N
-------
Q
------
G
H
E
I
A
A
R
Q
Q
K
G
-
F
-
G
A
M
L
S
F
E
L
D
G
D
E
Q
T
L
R
R
F
L
G
G
L
S
L
F
T
L
A
E
S
L
G
G
V
E
S
L
I
S
H
A
A
T
M
T
H
A
G
M
A
P
E
A
R
A
A
A
G
I
S
E
T
L
L
R
I
S
T
G
I
E
D
G
E
D
L
I
A
D
L
E
N
G
F
R
A
A
N
KG
43
HHSearch
52.23
19%
-94
- C1 -
3RI6
-
?
A:
[60-356]
-----------------------------------------------------------------------
T
---
V
E
D
L
E
Q
R
L
K
N
L
T
G
A
L
G
V
L
A
---
L
G
S
G
M
---
A
A
I
S
T
A
I
L
T
L
A
R
A
G
D
S
V
V
T
-
T
D
-
R
L
-
F
G
H
-
T
L
S
L
F
-------
Q
-
K
T
L
P
S
F
G
I
E
V
R
F
V
D
V
-----
M
D
S
L
A
V
E
H
A
C
D
-
E
--
T
T
K
L
L
F
L
E
T
I
----
S
N
P
Q
L
Q
V
A
D
L
E
A
L
S
K
V
V
H
A
-
K
----
G
I
P
L
V
V
D
T
T
M
T
P
P
Y
L
-
L
E
A
K
R
L
G
V
D
----
I
E
V
L
S
S
T
K
F
I
-
S
G
G
G
T
S
V
G
G
V
L
I
D
H
-
G
L
--
F
E
W
------
K
S
LPSL
A
P
Y
Y
A
K
AGPM
A
F
L
Y
-----
K
A
R
K
E
V
F
Q
N
L
G
P
--
S
L
S
P
H
N
A
Y
L
Q
S
L
G
L
E
T
M
-
A
L
R
I
E
R
S
C
Q
N
A
Q
E
L
A
H
W
--
L
L
S
---
I
P
Q
--
V
-----
K
---
C
-
V
--
N
------
H
------
P
------
S
LPDSPF
Y
A
I
------
A
K
R
Q
FR--
Y
------
A
G
S
I
L
T
F
E
L
E
S
-
K
-
E
A
S
Y
R
F
M
----
D
A
L
K
L
I
-------------------------------------------------------------------------
33
HHSearch
51.92
23%
-80
- C1 -
1GC0
-
MEGL_PSEPU
A:
[65-334]
-------------------------------------------------------------------
P
---
T
---
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
---
L
A
S
G
M
---
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
-
G
N
-
T
L
-
Y
G
C
-
T
F
A
F
L
-------
H
-
H
G
I
G
E
F
G
V
K
L
R
H
V
D
M
A
-----
D
L
Q
A
L
E
A
A
M
T
-
P
--
A
T
R
V
I
Y
F
E
S
P
----
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
-
H
----
G
A
T
V
V
V
D
N
T
Y
C
T
P
Y
L
-
Q
R
P
L
E
L
G
A
D
----
L
V
V
H
S
A
T
K
Y
L
-
S
G
H
G
D
I
T
A
G
I
V
V
G
S
-
Q
A
-
L
V
D
R
------
I
R
-----------------------
L
-
Q
G
-
L
K
D
M
T
G
A
--
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
-
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
--
L
A
R
---
Q
P
Q
--
V
-----
E
---
L
-
I
HY
P
--------------------------------------------
Q
------
P
G
G
M
I
A
F
E
L
K
G
-
G
I
G
A
G
R
R
F
M
----
N
A
L
Q
L
--------------------------------------------------------------------------
38
HHSearch
51.83
19%
-86
- C1 -
1IBJ
4
METC_ARATH
A:
[123-399]
---------------------------------------------------------
G
P
Y
D
Y
T
R
---
S
---
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
---
F
T
S
G
M
---
A
A
L
S
A
V
T
-
H
L
I
K
N
G
E
E
I
V
A
-
G
D
-
D
V
-
Y
G
G
-
S
D
R
L
L
-------
S
-
Q
V
V
P
R
S
G
V
V
V
K
R
V
N
T
T
-----
K
L
D
E
V
A
A
A
I
G
-
P
--
Q
T
K
L
V
W
L
E
S
P
----
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
A
-
Q
----
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
----
I
V
M
H
S
A
T
K
F
I
-
A
G
H
S
D
V
M
A
G
V
L
A
V
K
-
G
E
K
L
A
K
E
------
V
Y
-----------------------
F
-
L
Q
-
N
S
--
E
G
S
--
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
-
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
--
L
S
S
---
H
P
R
--
V
-----
K
K
--
V
Y
Y
--
A
------
G
------
L
PDHPG
H
H
--------
L
------
H
F
S
Q
A
K--
G
------
A
G
S
V
F
S
F
I
T
G
S
-
V
-
A
L
S
K
H
L
V
----
E
T
T
K
Y
--------------------------------------------------------------------------
37
HHSearch
51.13
21%
-74
- C1 -
1N8P
2
CYS3_YEAST
A:
[45-327]
---------------------------------------------------------
G
T
Y
E
Y
S
R
SQN
P
---
N
---
R
E
N
L
E
R
A
V
A
A
L
E
N
A
Q
Y
G
L
A
---
F
S
S
G
S
---
A
T
T
A
T
I
L
Q
S
-
L
P
Q
G
S
H
A
V
S
-
I
G
-
D
V
-
Y
G
G
-
T
H
R
Y
F
-------
T
-
K
V
A
N
A
H
G
V
E
T
S
F
T
N
D
------
L
L
N
D
L
P
Q
L
I
K
-
E
--
N
T
K
L
V
W
I
E
T
P
----
T
N
P
T
L
K
V
T
D
I
Q
K
V
A
D
L
I
K
K
-
H
A
AG
Q
D
V
I
L
V
V
D
N
T
F
L
S
P
Y
I
-
S
N
P
L
N
F
G
A
D
----
I
V
V
H
S
A
T
K
Y
I
N
G
H
S
D
-
V
V
L
G
V
L
A
T
N
N
K
P
-
L
Y
E
R
------
L
Q
-----------------------
F
-
L
Q
-
N
A
I
G
A
----
I
P
S
P
F
D
A
W
L
T
H
R
G
L
K
T
L
-
H
L
R
V
R
Q
A
A
L
S
A
N
K
I
A
E
F
--
L
A
A
---
D
-
K
EN
V
V
A
V
N
Y
P
GLK
T
-
H
--
P
------
N
------
Y
------
D
--------
V
------
V
L
K
QHRDA
L
------
G
G
G
M
I
S
F
R
I
K
G
-
G
A
E
A
A
S
K
F
A
----
S
S
T
R
---------------------------------------------------------------------------