@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1299: (2016-03-23 )
MAKYTKEDIFRFADEQNVKFIRLQFTDILGIIKNVEIPVSQLKKALDNKIMFDGSSIEGFVRIEESDMYLFPDLDTWVVFPWTAEKGKVARMICDIYNPDMTPFAGDPRANLKRVLKEMEELGFTEFNLGPEPEFFLFKLDENRRPTLELNDSGGYFDLAPTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYEDAVTACDSIQTFKLVVKTIARKHGLHATFMPKPLFGVNGSGMHFNMSLFNEKGNAFFDESGELELSQTAYHFLAGMLKHARGYTAVTNPTINSFKRLVPGYEAPCYIAWSGKNRSPLVRVPSSRGLSTRLELRSVDPSANPYLAMAVLLKAGLSGIKDELTPPAPVDRNIYGMNEEEREATGIYDLPESLGHALIELEKDDIIKAGLGEHIFEHFIEAKTIECDMFRTAVHPWEREQYLEIY
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKY
T
K
E
D
I
F
R
FADEQN
V
K
F
I
R
L
Q
F
T
D
I
L
G
I
I
KNVEI
P
V
S
Q
L
K
K
ALDN
K
I
M
FDGSSI
E
G
F
V
R
I
EES
D
M
Y
LFPDLD
T
W
V
V
F
P
WTAEK
G
K
V
A
R
M
I
C
D
IYNPDMTPFAGD
P
R
A
N
L
K
R
V
L
K
E
M
E
E
LGFTEFNLGPEP
E
F
F
L
F
KLDENRRP
T
L
E
LNDSGG
Y
F
DLAPTD
L
G
E
N
C
R
R
D
I
V
L
E
L
E
EM
G
F
E
I
EASHHEVAPGQ
H
E
I
D
F
K
YE
D
A
VTACD
S
I
Q
T
F
K
L
V
V
K
T
I
A
R
KHGLHATFMPKPLFGVNGS
G
M
H
F
N
M
S
L
FNEKGNAFFDESGEL
E
L
S
Q
T
A
Y
H
F
L
A
G
M
L
K
HARGYTAVTNP
T
I
N
S
F
K
R
LVPGYEA
P
C
Y
I
A
WSGKNRS
P
L
V
RVPSSRGL
S
T
R
L
E
L
R
SVDPSA
N
P
Y
L
A
M
A
V
L
L
K
AGLSGIKDELTPPAPVDRNIYGM
N
E
E
E
R
EATGIYD
L
P
E
S
L
G
H
A
L
I
ELEK
D
D
I
I
K
A
G
L
G
E
H
I
F
E
H
F
I
E
AKTI
E
C
D
M
F
R
T
AVH
P
W
E
R
E
Q
Y
LEIY
4
PsiBlast_PDB
99.20
77%
-89
- C4 -
4LNO
4
GLNA_BACSU
A:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
63
PsiBlast_CBE
98.70
77%
-85
- C4 -
4LNI
6
GLNA_BACSU
C:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
33
PsiBlast_CBE
98.57
77%
-88
- C4 -
4LNO
5
GLNA_BACSU
F:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
54
PsiBlast_CBE
98.51
77%
-87
- C4 -
4LNI
28
GLNA_BACSU
L:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
69
PsiBlast_CBE
98.39
77%
-85
- C4 -
4LNF
20
GLNA_BACSU
H:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
36
PsiBlast_CBE
98.37
77%
-89
- C4 -
4LNO
4
GLNA_BACSU
C:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
75
PsiBlast_CBE
98.19
77%
-87
- C4 -
4LNF
4
GLNA_BACSU
B:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
37
PsiBlast_CBE
98.12
77%
-89
- C4 -
4LNO
4
GLNA_BACSU
B:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
55
PsiBlast_CBE
97.90
77%
-86
- C4 -
4LNI
28
GLNA_BACSU
K:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
2
PsiBlast_PDB
97.89
77%
-85
- C4 -
4LNF
5
GLNA_BACSU
A:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
62
PsiBlast_CBE
97.86
77%
-86
- C4 -
4LNI
2
GLNA_BACSU
D:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
64
PsiBlast_CBE
97.64
77%
-87
- C4 -
4LNI
7
GLNA_BACSU
B:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
74
PsiBlast_CBE
97.27
77%
-84
- C4 -
4LNF
6
GLNA_BACSU
C:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
35
PsiBlast_CBE
97.20
77%
-86
- C4 -
4LNO
4
GLNA_BACSU
D:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
52
PsiBlast_CBE
97.14
77%
-88
- C4 -
4LNK
7
GLNA_BACSU
C:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
73
PsiBlast_CBE
97.09
77%
-86
- C4 -
4LNF
2
GLNA_BACSU
D:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
34
PsiBlast_CBE
97.03
77%
-86
- C4 -
4LNO
4
GLNA_BACSU
E:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
49
PsiBlast_CBE
96.82
77%
-85
- C4 -
4LNK
1
GLNA_BACSU
F:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
70
PsiBlast_CBE
96.69
77%
-83
- C4 -
4LNF
20
GLNA_BACSU
G:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
G
Y
E
A
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y
3
PsiBlast_PDB
96.43
77%
-89
- C4 -
4LNN
2
GLNA_BACSU
A:
[1-443]
-
A
K
Y
T
R
E
D
I
E
K
L
V
K
E
E
N
V
K
Y
I
R
L
Q
F
T
D
I
L
G
T
I
K
N
V
E
I
P
V
S
Q
L
G
K
A
L
D
N
K
V
M
F
D
G
S
S
I
E
G
F
V
R
I
E
E
S
D
M
Y
L
Y
P
D
L
N
T
F
V
I
F
P
W
T
A
E
K
G
K
V
A
R
F
I
C
D
I
Y
N
P
D
G
T
P
F
E
G
D
P
R
N
N
L
K
R
I
L
K
E
M
E
D
L
G
F
S
D
F
N
L
G
P
E
P
E
F
F
L
F
K
L
D
E
K
G
E
P
T
L
E
L
N
D
K
G
G
Y
F
D
L
A
P
T
D
L
G
E
N
C
R
R
D
I
V
L
E
L
E
E
M
G
F
E
I
E
A
S
H
H
E
V
A
P
G
Q
H
E
I
D
F
K
Y
A
G
A
V
R
S
C
D
D
I
Q
T
F
K
L
V
V
K
T
I
A
R
K
H
G
L
H
A
T
F
M
P
K
P
L
F
G
V
N
G
S
G
M
H
C
N
L
S
L
F
K
N
G
V
N
A
F
F
D
E
N
A
D
L
Q
L
S
E
T
A
K
H
F
I
A
G
I
V
K
H
A
T
S
F
T
A
V
T
N
P
T
V
N
S
Y
K
R
L
V
P
----
P
C
Y
V
A
W
S
A
Q
N
R
S
P
L
I
R
I
P
A
S
R
G
I
S
T
R
V
E
V
R
S
V
D
P
A
A
N
P
Y
L
A
L
S
V
L
L
A
A
G
L
D
G
I
K
N
K
L
E
A
P
A
P
I
D
R
N
I
Y
V
M
S
K
E
E
R
M
E
N
G
I
V
D
L
P
A
T
L
A
E
A
L
E
E
F
K
S
N
E
V
M
V
K
A
L
G
E
H
L
F
E
H
F
I
E
A
K
E
I
E
W
D
M
F
R
T
Q
V
H
P
W
E
R
E
Q
Y
M
S
Q
Y