@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1317: (2016-03-23 )
MKKIILLGATGSIGTQTLAIIRENPEKFQVVALSFGRNMERGRAIIKEFKPKMVAVWHTRDRVTLEAEFPNVKFFNGLEGLREVATYLDGDVLLNAVMGSVGLLPTLDAIEAGKAIAIANKETLVTAGHLVMRAAKEKNISLLPVDSEHSAILQALNGENTERIEKIILTASGGSFRDKTREQLSAVTVKEALKHPNWNMGNKLTIDSATMFNKGLEVMEAHWLFGVDYDDIEVVIQRESIIHSMVQFVDGSFIAQLGTPDMRMPIQYALTYPDRLYIPYEKEFRITDFSALHFEKVDYERFPALKLAYNAGKIGGTMPTVLNAANEIAVAGFLNGQVAFYNIEALVENAMNRHTSISNPDLDTILQVDQETRAYVKTLL
Atome Classification :
(70 SA)
.........10........20.....---...30.....----...40........50........60----........--70---......-----...80........90........100.......110.......120.......130....-...140.......150....---------------...160--------.........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......---290.......300.......310.......320.......330.......340.......350......-.360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
I
I
L
LGATGSIG
T
Q
T
L
A
I
IRENPE---
K
F
Q
V
V
A
LSFG----RN
M
E
R
G
R
A
I
I
K
EFKP
K
M
V
A
V
W
HTR
D
----
R
V
T
L
E
AEF--P----N
V
K
F
F
N
-----
G
L
E
G
L
R
E
V
A
T
YLD
G
D
V
L
L
N
A
V
M
GSVGLLP
T
L
D
A
IEAG
K
A
I
A
IANKE
T
L
V
T
A
G
H
L
V
M
R
A
AK-EKN
I
S
L
L
PVDS
E
H
S
A
I
L
Q
A
L---------------NGE
N
----------
T
E
R
I
E
K
I
I
L
TASGGSF
R
D
K
T
R
E
Q
L
S
A
V
T
V
K
E
A
LKHPNWNMG
N
K
L
T
ID
S
A
T
M
F
N
K
G
L
E
V
M
E
A
H
W
L
F
GV
D
Y
D
D
I
E
V
V
I
Q
R
E
S
I
I
H
S
M
V
Q
FV
D
G
S
F
I
A
QLGTPDMR
M
P
I
Q
Y
A
LTYP
D
R
L
Y
IPYEK
E
F
RITDF---
S
A
L
H
F
EKV
D
Y
E
RF
P
A
L
K
L
A
YNAGKIGGT
M
P
T
V
L
NAAN
E
I
A
V
A
G
FLNG
Q
V
A
F
Y
N
I
E
A
L
V
E
N
A
M
NRHTSIS-NP
D
L
D
T
I
L
Q
V
D
Q
E
T
R
A
Y
V
K
T
LL
30
PsiBlast_CBE
94.09
42%
-104
- C2 -
3R0I
2
DXR_ECOLI
B:
[13-398]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
AKLL
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
-----
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
10
PsiBlast_PDB
93.41
42%
-103
- C2 -
3R0I
2
DXR_ECOLI
A:
[13-398]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
-----
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
15
PsiBlast_PDB
93.23
41%
-95
- C2 -
1T1R
2
DXR_ECOLI
A:
[2-386]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
101
HHSearch
93.21
43%
-94
- C2 -
1Q0Q
2
DXR_ECOLI
A:
[9-401]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
----
A
K
L
L
K
T
M
L
--
Q
Q
Q
GS
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
---------------
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
-
G
V
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
16
PsiBlast_PDB
92.95
41%
-97
- C2 -
1T1S
3
DXR_ECOLI
A:
[2-386]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
33
PsiBlast_CBE
92.92
41%
-97
- C2 -
3ANL
2
DXR_ECOLI
B:
[12-396]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
AKLL
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
13
PsiBlast_PDB
92.85
41%
-97
- C2 -
3ANN
2
DXR_ECOLI
A:
[12-396]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
26
PsiBlast_CBE
92.82
41%
-103
- C2 -
1R0K
1
DXR_ZYMMO
B:
[5-383]
-
R
T
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
R
N
L
D
---
R
Y
Q
V
I
A
L
T
A
N
----
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
----
Y
N
D
L
K
E
A
L
AG
S
----
S
V
E
A
A
A
-----
G
A
D
A
L
V
E
A
A
-
M
M
G
A
D
W
T
M
A
A
I
I
G
C
A
G
L
K
A
T
L
A
A
I
R
K
G
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
G
L
M
I
D
A
V
R
-
E
H
G
T
T
L
L
P
V
D
S
E
H
N
A
I
F
Q
C
F
---------------
P
H
H
N
----------
R
D
Y
V
R
R
I
I
I
T
A
S
G
G
P
F
R
T
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
H
P
--
S
M
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
A
W
P
K
R
M
E
T
P
A
E
S
-
L
D
F
T
K
L
---
R
Q
M
D
F
E
A
P
D
Y
E
R
F
P
A
L
T
L
A
M
E
S
I
K
S
G
G
A
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
-
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
A
A
L
M
36
PsiBlast_CBE
92.68
41%
-97
- C2 -
1T1R
2
DXR_ECOLI
B:
[2-386]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
AKLL
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
27
PsiBlast_CBE
92.67
42%
-97
- C2 -
1Q0Q
2
DXR_ECOLI
B:
[9-394]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
AKLL
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
32
PsiBlast_CBE
92.63
41%
-96
- C2 -
3ANM
2
DXR_ECOLI
B:
[12-396]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
AKLL
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
9
PsiBlast_PDB
92.57
42%
-96
- C2 -
1Q0Q
2
DXR_ECOLI
A:
[9-394]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
34
PsiBlast_CBE
92.47
41%
-95
- C2 -
2EGH
3
DXR_ECOLI
B:
[12-396]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
AKLL
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
14
PsiBlast_PDB
92.41
41%
-97
- C2 -
2EGH
3
DXR_ECOLI
A:
[12-396]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
11
PsiBlast_PDB
92.40
41%
-97
- C2 -
3ANL
2
DXR_ECOLI
A:
[12-396]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
35
PsiBlast_CBE
92.35
41%
-96
- C2 -
1T1S
2
DXR_ECOLI
B:
[2-386]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
AKLL
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
25
PsiBlast_CBE
92.31
41%
-103
- C2 -
1R0K
1
DXR_ZYMMO
D:
[5-383]
-
R
T
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
R
N
L
D
---
R
Y
Q
V
I
A
L
T
A
N
----
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
----
Y
N
D
L
K
E
A
L
AG
S
----
S
V
E
A
A
A
-----
G
A
D
A
L
V
E
A
A
-
M
M
G
A
D
W
T
M
A
A
I
I
G
C
A
G
L
K
A
T
L
A
A
I
R
K
G
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
G
L
M
I
D
A
V
R
-
E
H
G
T
T
L
L
P
V
D
S
E
H
N
A
I
F
Q
C
F
---------------
P
H
H
N
----------
R
D
Y
V
R
R
I
I
I
T
A
S
G
G
P
F
R
T
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
H
P
---
M
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
A
W
P
K
R
M
E
T
P
A
E
S
-
L
D
F
T
K
L
---
R
Q
M
D
F
E
A
P
D
Y
E
R
F
P
A
L
T
L
A
M
E
S
I
K
S
G
G
A
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
-
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
A
A
L
M
12
PsiBlast_PDB
92.26
41%
-96
- C2 -
3ANM
2
DXR_ECOLI
A:
[12-396]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
5
PsiBlast_PDB
92.09
42%
-98
- C2 -
1ONN
-
DXR_ECOLI
A:
[1-386]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
--------
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
6
PsiBlast_PDB
91.64
42%
-99
- C2 -
1ONO
1
DXR_ECOLI
A:
[1-386]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
--------
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
7
PsiBlast_PDB
91.55
42%
-98
- C2 -
1ONP
2
DXR_ECOLI
A:
[1-386]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
31
PsiBlast_CBE
91.46
41%
-97
- C2 -
3ANN
2
DXR_ECOLI
B:
[12-396]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
AKLL
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
8
PsiBlast_PDB
91.19
42%
-94
- C2 -
1Q0L
2
DXR_ECOLI
A:
[9-394]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
28
PsiBlast_CBE
89.93
42%
-96
- C2 -
1ONP
2
DXR_ECOLI
B:
[1-386]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
---
H
F
R
V
V
A
L
V
A
G
----
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
AKLL
K
T
M
L
Q
Q
Q
G
--
S
----
R
T
E
V
L
S
-----
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLEQ
N
G
---------------
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
-
K
P
L
D
F
C
K
L
---
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
-------
42
PsiBlast_CBE
88.78
40%
-102
- C2 -
4Y67
2
DXR_PLAF7
B:
[14-387]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
IEN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PIILC
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
DNNKVLKTKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
41
PsiBlast_CBE
88.45
40%
-103
- C2 -
4Y6P
4
DXR_PLAF7
B:
[14-387]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
IEN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PIILC
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
DNNKVLKTKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
39
PsiBlast_CBE
88.26
40%
-104
- C2 -
4Y6S
2
DXR_PLAF7
A:
[14-387]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PI
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
L
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
38
PsiBlast_CBE
88.20
40%
-100
- C2 -
4Y6S
2
DXR_PLAF7
B:
[14-387]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
IEN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PIILC
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
DNNKVLKTKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
20
PsiBlast_PDB
88.19
40%
-100
- C2 -
4Y6R
3
DXR_PLAF7
A:
[14-387]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PI
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
L
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
55
PsiBlast_CBE
88.15
40%
-100
- C2 -
4GAE
8
DXR_PLAFX
B:
[18-391]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
I
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
44
PsiBlast_CBE
88.01
40%
-101
- C2 -
3WQR
5
DXR_PLAFX
B:
[80-453]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
IEN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PIILC
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
DNNKVLKTKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
40
PsiBlast_CBE
88.00
40%
-102
- C2 -
4Y6R
3
DXR_PLAF7
B:
[14-387]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
IEN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PIILC
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
DNNKVLKTKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
54
PsiBlast_CBE
87.87
40%
-103
- C2 -
4KP7
3
DXR_PLAFX
A:
[19-392]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PI
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
L
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
19
PsiBlast_PDB
87.83
40%
-99
- C2 -
4Y6P
3
DXR_PLAF7
A:
[14-387]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PI
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
L
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
46
PsiBlast_CBE
87.62
40%
-102
- C2 -
3WQQ
5
DXR_PLAFX
B:
[80-453]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
IEN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PIILC
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
DNNKVLKTKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
18
PsiBlast_PDB
87.38
40%
-103
- C2 -
4Y67
2
DXR_PLAF7
A:
[14-387]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PI
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
L
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
50
PsiBlast_CBE
87.32
40%
-100
- C2 -
3AU9
5
DXR_PLAFX
B:
[80-453]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
IEN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PIILC
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
DNNKVLKTKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
48
PsiBlast_CBE
87.31
40%
-100
- C2 -
3AUA
5
DXR_PLAFX
B:
[80-453]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
IEN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PIILC
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
DNNKVLKTKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
51
PsiBlast_CBE
87.13
40%
-99
- C2 -
3AU9
4
DXR_PLAFX
A:
[80-453]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PI
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
L
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
45
PsiBlast_CBE
87.01
40%
-97
- C2 -
3WQR
4
DXR_PLAFX
A:
[80-453]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PI
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
L
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
56
PsiBlast_CBE
86.73
40%
-100
- C2 -
4GAE
7
DXR_PLAFX
A:
[18-391]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PI
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
I
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
53
PsiBlast_CBE
86.59
40%
-104
- C2 -
4KP7
2
DXR_PLAFX
B:
[19-392]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PI
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
L
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
------
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
49
PsiBlast_CBE
86.58
40%
-96
- C2 -
3AUA
4
DXR_PLAFX
A:
[80-453]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PI
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
L
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
47
PsiBlast_CBE
86.47
40%
-98
- C2 -
3WQQ
4
DXR_PLAFX
A:
[80-453]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
EN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PI
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
N
N
K
V
L
K
TKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
43
PsiBlast_CBE
86.40
40%
-98
- C2 -
3WQS
3
DXR_PLAFX
B:
[80-453]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
IEN
V
F
N
V
K
A
L
Y
V
N
----
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
----
Y
E
E
L
K
E
L
V
--
K
----
N
I
K
D
Y
K
PIILC
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
DNNKVLKTKCLQD--
N
F
S
K
----------
I
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
-
K
P
L
D
L
A
Q
V
---
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
-------------------------
104
HHSearch
83.59
37%
-96
- C2 -
3A06
4
DXR_THEMA
A:
[3-368]
E
R
T
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
K
K
V
K
----
G
I
R
L
I
G
I
S
F
H
----
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
G
D
V
E
----
F
E
D
S
-----------
S
I
N
V
W
K
-----
G
S
H
S
I
E
E
M
L
E
A
L
K
P
D
I
T
M
V
A
V
S
G
F
S
G
L
R
A
V
L
A
S
L
E
H
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
F
L
V
K
K
K
L
K
-
E
K
G
T
E
L
I
P
V
D
S
E
H
S
A
I
F
Q
V
M
---------------
E
P
--------------
E
V
E
K
V
V
L
T
A
S
G
G
A
L
R
D
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
H
P
V
W
N
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
P
R
R
V
A
L
---
E
P
-
F
F
L
R
T
---
I
S
L
S
F
E
D
P
D
P
E
K
Y
P
A
F
F
L
L
K
E
I
K
D
-
S
Y
A
L
R
T
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
Y
P
Q
P
R
T
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
E
R
V
T
95
PsiBlast_CBE
83.51
42%
-95
- C2 -
2JCX
3
DXR_MYCTU
A:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
80
PsiBlast_CBE
83.44
43%
-96
- C2 -
2JCV
3
DXR_MYCTU
A:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
61
PsiBlast_CBE
83.34
43%
-96
- C2 -
4A03
3
DXR_MYCTU
B:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAHL
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
HTA
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
100
PsiBlast_CBE
83.30
43%
-95
- C2 -
4OOF
3
DXR_MYCTU
B:
[28-370]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAHL
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
F
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
HTA
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
82
PsiBlast_CBE
83.19
43%
-101
- C2 -
3ZI0
1
DXR_MYCTU
A:
[22-364]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
------------------
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
--------
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
87
PsiBlast_CBE
83.08
43%
-97
- C2 -
3ZHX
2
DXR_MYCTU
A:
[22-364]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
-------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
72
PsiBlast_CBE
82.90
43%
-102
- C2 -
2Y1D
2
DXR_MYCTU
A:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
-----------------
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
----------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
78
PsiBlast_CBE
82.80
43%
-93
- C2 -
2JD1
4
DXR_MYCTU
A:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
64
PsiBlast_CBE
82.79
43%
-98
- C2 -
3RAS
4
DXR_MYCTU
A:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
68
PsiBlast_CBE
82.72
43%
-98
- C2 -
2Y1F
4
DXR_MYCTU
A:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
------
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
85
PsiBlast_CBE
82.63
43%
-98
- C2 -
3ZHY
3
DXR_MYCTU
A:
[22-364]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
66
PsiBlast_CBE
82.58
43%
-97
- C2 -
2Y1G
4
DXR_MYCTU
A:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
79
PsiBlast_CBE
82.41
43%
-96
- C2 -
2JCV
2
DXR_MYCTU
B:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAHL
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
HTA
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
89
PsiBlast_CBE
82.34
43%
-96
- C2 -
4RCV
4
?
A:
[29-371]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
--------
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
84
PsiBlast_CBE
82.31
43%
-96
- C2 -
3ZHY
3
DXR_MYCTU
B:
[22-364]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
--------
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
62
PsiBlast_CBE
82.20
43%
-96
- C2 -
4A03
4
DXR_MYCTU
A:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
59
PsiBlast_CBE
82.13
43%
-96
- C2 -
4AIC
3
DXR_MYCTU
B:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAHL
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
HTA
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
60
PsiBlast_CBE
82.12
43%
-95
- C2 -
4AIC
4
DXR_MYCTU
A:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
88
PsiBlast_CBE
82.05
43%
-96
- C2 -
4RCV
3
?
B:
[29-371]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
--
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
94
PsiBlast_CBE
81.69
42%
-97
- C2 -
2JCX
2
DXR_MYCTU
B:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAHL
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
HTA
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
63
PsiBlast_CBE
81.40
43%
-96
- C2 -
3RAS
5
DXR_MYCTU
B:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAHL
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
HTA
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
83
PsiBlast_CBE
81.15
43%
-100
- C2 -
3ZHZ
1
DXR_MYCTU
A:
[22-364]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
--------------
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
-------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
91
PsiBlast_CBE
80.74
42%
-95
- C2 -
2JD0
3
DXR_MYCTU
A:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------
67
PsiBlast_CBE
80.50
43%
-94
- C2 -
2Y1F
3
DXR_MYCTU
B:
[23-365]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
---
R
F
E
V
V
G
L
A
A
G
GAH
L
D
T
L
L
R
Q
R
A
Q
T
G
-
V
T
N
I
A
V
A
D
E
H
A
A
Q
----
R
V
---
G
D
I
--
P
--------
Y
H
-----
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
Q
I
--
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
---------------
R
G
G
T
----------
P
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
----
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
-----------------------------