@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1322: (2016-03-23 )
MSTELLDALHVLEHDKGISREVLVEAIEAALTSAYKRNFKDAQNVRVDLNMENGSIRVLARKEAVEQVFDSRLEISMEEAHKLNPVYQPGDVVELEVTPKDFGRIAAQTAKQVVTQRVREAERGIIYDEFIDREDDIMTGIVERQDSRFIYVNLGKIEAILSQNEQMPNETYHAHDRIKVYLTKVEKTTKGPQIFVSRTHPGLLKRLFEMEVPEIYDGVVEIKSVAREAGDRSKISVYTANEEVDPVGACVGPKGARVQTIVNELKGEKIDIVEWSEDPFTFVANALSPSKVLDVIVNEADQATTVIVPDYQLSLAIGKRGQNARLAAKLTGWKIDIKSETVATELGIYPRNGVEAPEVEEAESETFTEDEE
Atome Classification :
(20 SA)
----------------------------------.........10.......-.20........30........40........-50........60........70........80.........90.......-.100.......110.......120.......130.......140.....----.-----.150..---.----...---.160.-....------.----------------.--170-.....-..180.......190------.........200.---......210.......220.......230-.--------------......240-------------........250.......260.......--270.......280....---...290....----------....-300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------M
S
T
E
L
L
D
A
L
H
V
L
E
HDKGI-
S
R
E
V
L
V
E
A
I
E
A
A
L
T
S
A
Y
K
RNFKDA
Q
N
V
R
V
D
L
-
N
MENG
S
I
R
V
L
A
R
K
E
A
V
E
Q
V
F
D
S
R
L
E
I
S
M
E
E
A-HKLNPVYQPG
D
V
V
E
L
E
V
T
-
P
K
D
F
G
R
I
A
A
Q
T
A
K
Q
V
V
T
Q
R
V
R
E
A
ERGI
I
Y
D
E
FIDRE
D
D
I
M
T
G
I
V
ERQDS----
R
-----
F
I
Y
V
N
L
---
G
----
K
I
E
---
A
I
L
S
Q-NEQM------P----------------N--ETY-HAH
D
R
-
I
K
V
Y
L
T
K
V
EKTTK--------G
P
Q
I
F
V
SRT
H
P
G
L
---
L
K
R
L
F
EME
V
P
E
I
Y
D
G
V
V
E
I
K
S
V
A
R
EAGDR-
S
--------------
K
I
S
V
Y
TAN--------------EEVDPVGACVGPKG
A
R
V
Q
T
I
V
N
E
LKG
E
K
--
I
D
I
V
EWSED
P
F
T
F
V
A
NA---L
S
P
S
K
-
V
L
D
V
----------
I
VNE-ADQ
A
T
T
V
I
VPD
Y
Q
L
S
L
A
IGKRGQN
A
R
L
A
A
K
L
T
G
W
K
I
D
IKSETV
A
T
ELGIYPRNGVEAPE
V
E
EAESETFTEDEE
21
HHSearch
92.41
47%
-73
- C6 -
1HH2
-
?
P:
[1-341]
----------------------------------
M
N
I
G
L
L
E
A
L
D
Q
L
E
E
E
K
G
I
-
S
K
E
E
V
I
P
I
L
E
K
A
L
V
S
A
Y
R
K
N
F
G
N
S
K
N
V
E
V
V
I
-
D
R
N
T
G
N
I
K
V
Y
Q
L
L
E
V
V
E
E
V
E
D
P
A
T
Q
I
S
L
E
E
A
-
K
K
I
D
P
L
A
E
V
G
S
I
V
K
K
E
L
N
-
V
K
N
F
G
R
I
A
A
Q
T
A
K
Q
V
L
I
Q
R
I
R
E
L
E
K
E
K
Q
F
E
K
Y
S
E
L
K
G
T
V
T
T
A
E
V
I
R
V
M
G
----
E
-----
W
A
D
I
R
I
---
G
----
K
L
E
---
T
R
L
P
K
-
K
E
W
I
------
P
----------------
G
--
E
E
I
-
K
A
G
D
L
-
V
K
V
Y
I
I
D
V
V
K
T
T
K
--------
G
P
K
I
L
V
S
R
R
V
P
E
F
---
V
I
G
L
M
K
L
E
I
P
E
V
E
N
G
I
V
E
I
K
A
I
A
R
E
P
G
V
R
-
T
--------------
K
V
A
V
A
S
N
D
--------------
P
N
V
D
P
I
G
A
C
I
G
E
G
G
S
R
I
A
A
I
L
K
E
L
K
G
E
K
--
L
D
V
L
K
W
S
D
D
P
K
Q
L
I
A
N
A
---
L
A
P
A
T
-
V
I
E
V
----------
E
I
L
D
K
E
N
K
A
A
R
V
L
V
P
P
T
Q
L
S
L
A
I
G
K
G
G
Q
N
A
R
L
A
A
K
L
T
G
W
K
I
D
I
K
P
I
--------------------------------
43
Fugue
91.54
46%
-73
- C6 -
1HH2
-
?
P:
[1-344]
----------------------------------
M
N
I
G
L
L
E
A
L
D
Q
L
E
E
E
K
G
I
-
S
K
E
E
V
I
P
I
L
E
K
A
L
V
S
A
Y
R
K
N
F
G
N
S
K
N
V
E
V
V
I
-
D
R
N
T
G
N
I
K
V
Y
Q
L
L
E
V
V
E
E
V
E
D
P
A
T
Q
I
S
L
E
E
A
-
K
K
I
D
P
L
A
E
V
G
S
I
V
K
K
E
L
N
-
V
K
N
F
G
R
I
A
A
Q
T
A
K
Q
V
L
I
Q
R
I
R
E
L
E
K
E
K
Q
F
E
K
Y
S
E
L
K
G
T
V
T
T
A
E
V
I
R
V
M
G
----
E
-----
W
A
D
I
R
I
---
G
----
K
L
E
---
T
R
L
P
K
-
K
E
W
I
------
P
----------------
G
--
E
E
I
-
K
A
G
D
L
-
V
K
V
Y
I
I
D
V
V
K
T
T
K
--------
G
P
K
I
L
V
S
R
R
V
P
E
F
---
V
I
G
L
M
K
L
E
I
P
E
V
E
N
G
I
V
E
I
K
A
I
A
R
E
P
G
V
R
-
T
--------------
K
V
A
V
A
S
N
D
--------------
P
N
V
D
P
I
G
A
C
I
G
E
G
G
S
R
I
A
A
I
L
K
E
L
K
G
E
K
--
L
D
V
L
K
W
S
D
D
P
K
Q
L
I
A
N
A
---
L
A
P
A
T
-
V
I
E
V
E---------
I
L
D
K
-
E
N
K
A
A
R
V
L
V
P
P
T
Q
L
S
L
A
I
G
K
G
G
Q
N
A
R
L
A
A
K
L
T
G
W
K
I
D
I
K
P
I
M
N
L
-----------------------------
1
PsiBlast_PDB
91.29
47%
-75
- C6 -
1HH2
-
?
P:
[1-339]
----------------------------------
M
N
I
G
L
L
E
A
L
D
Q
L
E
E
E
K
G
I
-
S
K
E
E
V
I
P
I
L
E
K
A
L
V
S
A
Y
R
K
N
F
G
N
S
K
N
V
E
V
V
I
-
D
R
N
T
G
N
I
K
V
Y
Q
L
L
E
V
V
E
E
V
E
D
P
A
T
Q
I
S
L
E
E
A
-
K
K
I
D
P
L
A
E
V
G
S
I
V
K
K
E
L
N
-
V
K
N
F
G
R
I
A
A
Q
T
A
K
Q
V
L
I
Q
R
I
R
E
L
E
K
E
K
Q
F
E
K
Y
S
E
L
K
G
T
V
T
T
A
E
V
I
R
V
M
G
----
E
-----
W
A
D
I
R
I
---
G
----
K
L
E
---
T
R
L
P
K
-
K
E
W
I
------
P
----------------
G
--
E
E
I
-
K
A
G
D
L
-
V
K
V
Y
I
I
D
V
V
K
T
T
K
--------
G
P
K
I
L
V
S
R
R
V
P
E
F
---
V
I
G
L
M
K
L
E
I
P
E
V
E
N
G
I
V
E
I
K
A
I
A
R
E
P
G
V
R
-
T
--------------
K
V
A
V
A
S
N
D
--------------
P
N
V
D
P
I
G
A
C
I
G
E
G
G
S
R
I
A
A
I
L
K
E
L
K
G
E
K
--
L
D
V
L
K
W
S
D
D
P
K
Q
L
I
A
N
A
---
L
A
P
A
T
-
V
I
E
V
E---------
I
L
D
K
-
E
N
K
A
A
R
V
L
V
P
P
T
Q
L
S
L
A
I
G
K
G
G
Q
N
A
R
L
A
A
K
L
T
G
W
K
I
D
I
K
----------------------------------
3
PsiBlast_PDB
83.54
39%
-92
- C6 -
4MTN
2
?
A:
[11-314]
--------------------------------------
I
V
D
S
I
H
---
R
D
K
S
I
-
D
K
E
I
V
F
E
G
V
E
Q
A
I
L
S
A
A
R
K
H
F
G
E
E
E
V
I
E
V
H
I
-
D
R
T
S
G
Q
P
M
V
K
T
N
G
R
----------
E
I
D
R
D
E
L
----------
G
D
I
----------
L
G
R
I
S
A
Q
T
-
K
Q
V
M
I
Q
K
I
R
E
A
E
R
D
T
L
F
D
E
Y
A
Q
L
R
G
Q
I
V
S
G
T
V
T
R
N
E
G
----
S
-----
A
I
T
V
N
I
---
G
----
K
A
E
---
A
I
L
P
R
-
S
E
M
I
------
P
----------------
G
--
E
S
H
-
R
P
N
E
R
-
I
R
A
V
V
L
E
V
K
K
M
G
P
--------
R
V
R
V
V
L
S
R
A
H
P
D
F
---
V
R
R
L
L
E
L
E
I
P
E
V
N
E
R
I
I
E
I
R
S
L
A
R
E
A
G
Y
R
-
T
--------------
K
V
A
V
S
C
A
D
--------------
S
N
I
D
P
V
G
A
C
V
G
V
R
G
A
R
I
R
N
V
G
E
E
L
G
G
E
R
--
I
E
V
V
R
W
N
D
S
L
Q
V
L
V
P
N
A
---
M
Q
P
S
E
-
V
E
D
V
----------
I
L
C
P
-
M
L
G
R
V
L
V
L
V
R
D
D
Q
L
S
L
A
I
G
K
R
G
Q
N
V
R
L
A
S
K
L
V
G
W
D
I
D
V
M
T
---------------------------------
20
PsiBlast_CBE
79.68
48%
-84
- C6 -
2ATW
1
NUSA_MYCTU
C:
[2-223]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
S
T
R
E
G
E
I
V
A
G
V
I
Q
R
-
D
S
----
R
ANARG
L
V
V
V
R
I
---
G
TETK
A
S
E
---
G
V
I
P
A
-
A
E
Q
V
------
P
----------------
G
--
E
S
Y
-
E
H
G
N
R
-
L
R
C
Y
V
V
G
V
T
R
G
A
R
--------
E
P
L
I
T
L
S
R
T
H
P
N
L
---
V
R
K
L
F
S
L
E
V
P
E
I
A
D
G
S
V
E
I
V
A
V
A
R
E
A
G
H
R
-
S
--------------
K
I
A
V
R
S
N
V
--------------
A
G
L
N
A
K
G
A
C
I
G
P
M
G
Q
R
V
R
N
V
M
S
E
L
S
G
E
K
--
I
D
I
I
D
Y
D
D
D
P
A
R
F
V
A
N
A
---
L
S
P
A
K
-
V
V
S
V
S---------
V
I
D
Q
-
T
A
R
A
A
R
V
V
V
P
D
F
Q
L
S
L
A
I
G
K
E
G
Q
N
A
R
L
A
A
R
L
T
G
W
R
I
D
I
R
G
D
A
-------------------------------
23
HHSearch
78.04
49%
-80
- C6 -
2ASB
1
NUSA_MYCTU
A:
[4-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
R
E
G
E
I
V
A
G
V
I
Q
R
D
S
R
A
N
A
R
G
-----
L
V
V
V
R
I
---
G
T
E
T
K
A
S
E
---
G
V
I
P
A
-
A
E
Q
V
------
P
----------------
G
--
E
S
Y
-
E
H
G
N
R
-
L
R
C
Y
V
V
G
V
T
R
G
A
R
--------
E
P
L
I
T
L
S
R
T
H
P
N
L
---
V
R
K
L
F
S
L
E
V
P
E
I
A
D
G
S
V
E
I
V
A
V
A
R
E
A
G
H
R
-
S
--------------
K
I
A
V
R
S
N
V
--------------
A
G
L
N
A
K
G
A
C
I
G
P
M
G
Q
R
V
R
N
V
M
S
E
L
S
G
E
K
--
I
D
I
I
D
Y
D
D
D
P
A
R
F
V
A
N
A
---
L
S
P
A
K
-
V
V
S
V
----------
S
V
I
D
Q
T
A
R
A
A
R
V
V
V
P
D
F
Q
L
S
L
A
I
G
K
E
G
Q
N
A
R
L
A
A
R
L
T
G
W
R
I
D
I
R
G
D
A
P
P
P
P
P
G
-------------------------
4
PsiBlast_PDB
77.99
48%
-82
- C6 -
2ASB
1
NUSA_MYCTU
A:
[4-223]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
R
E
G
E
I
V
A
G
V
I
Q
R
-
D
S
----
R
A
N
A
R
G
L
V
V
V
R
I
---
G
T
E
T
K
A
S
E
---
G
V
I
P
A
-
A
E
Q
V
------
P
----------------
G
--
E
S
Y
-
E
H
G
N
R
-
L
R
C
Y
V
V
G
V
T
R
G
A
R
--------
E
P
L
I
T
L
S
R
T
H
P
N
L
---
V
R
K
L
F
S
L
E
V
P
E
I
A
D
G
S
V
E
I
V
A
V
A
R
E
A
G
H
R
-
S
--------------
K
I
A
V
R
S
N
V
--------------
A
G
L
N
A
K
G
A
C
I
G
P
M
G
Q
R
V
R
N
V
M
S
E
L
S
G
E
K
--
I
D
I
I
D
Y
D
D
D
P
A
R
F
V
A
N
A
---
L
S
P
A
K
-
V
V
S
V
S---------
V
I
D
Q
-
T
A
R
A
A
R
V
V
V
P
D
F
Q
L
S
L
A
I
G
K
E
G
Q
N
A
R
L
A
A
R
L
T
G
W
R
I
D
I
R
G
D
A
-------------------------------
5
PsiBlast_PDB
76.76
48%
-79
- C6 -
2ATW
1
NUSA_MYCTU
A:
[3-223]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
T
R
E
G
E
I
V
A
G
V
I
Q
R
-
D
S
----
R
A
N
A
R
G
L
V
V
V
R
I
---
G
T
ET
K
A
S
E
---
G
V
I
P
A
-
A
E
Q
V
------
P
----------------
G
--
E
S
Y
-
E
H
G
N
R
-
L
R
C
Y
V
V
G
V
T
R
G
A
R
--------
E
P
L
I
T
L
S
R
T
H
P
N
L
---
V
R
K
L
F
S
L
E
V
P
E
I
A
D
G
S
V
E
I
V
A
V
A
R
E
A
G
H
R
-
S
--------------
K
I
A
V
R
S
N
V
--------------
A
G
L
N
A
K
G
A
C
I
G
P
M
G
Q
R
V
R
N
V
M
S
E
L
S
G
E
K
--
I
D
I
I
D
Y
D
D
D
P
A
R
F
V
A
N
A
---
L
S
P
A
K
-
V
V
S
V
S
---------
V
I
D
Q
-
T
A
R
A
A
R
V
V
V
P
D
F
Q
L
S
L
A
I
G
K
E
G
Q
N
A
R
L
A
A
R
L
T
G
W
R
I
D
I
R
G
D
A
-------------------------------
2
PsiBlast_PDB
72.59
47%
-14
- C6 -
1L2F
-
?
A:
[5-339]
--------------------------------------
L
L
E
A
L
D
Q
L
E
E
E
K
G
I
-
S
K
E
E
V
I
P
I
L
E
K
A
L
V
S
A
Y
R
K
N
F
G
N
S
K
N
V
E
V
V
I
-
D
R
N
T
G
N
I
K
V
Y
Q
L
L
E
V
V
E
E
V
E
D
P
A
T
Q
I
S
L
E
E
A
-
K
K
I
D
P
L
A
E
V
G
S
I
V
K
K
E
L
N
-
V
K
N
F
G
R
I
A
A
Q
T
A
K
Q
V
L
I
Q
R
I
R
E
L
E
K
E
K
Q
F
E
K
Y
S
E
L
K
G
T
V
T
T
A
E
V
I
R
V
M
G
----
E
-----
W
A
D
I
R
I
---
G
----
K
L
E
---
T
R
L
P
K
-
K
E
W
I
------
P
----------------
G
--
E
E
I
-
K
A
G
D
L
-
V
K
V
Y
I
I
D
V
V
K
T
T
K
--------
G
P
K
I
L
V
S
R
R
V
P
E
F
---
V
I
G
L
M
K
L
E
I
P
E
V
E
N
G
I
V
E
I
K
A
I
A
R
E
P
G
V
R
-
T
--------------
K
V
A
V
A
S
N
D
--------------
P
N
V
D
P
I
G
A
C
I
G
E
G
G
S
R
I
A
A
I
L
K
E
L
K
G
E
K
--
L
D
V
L
K
W
S
D
D
P
K
Q
L
I
A
N
A
---
L
A
P
A
T
-
V
I
E
V
E---------
I
L
D
K
-
E
N
K
A
A
R
V
L
V
P
P
T
Q
L
S
L
A
I
G
K
G
G
Q
N
A
R
L
A
A
K
L
T
G
W
K
I
D
I
K
----------------------------------
6
PsiBlast_PDB
51.12
34%
-39
- C6 -
2KWP
-
NUSA_ECOLI
A:
[1-126]
----------------------------------
M
N
K
E
I
L
A
V
V
E
A
V
S
N
E
K
A
L
-
P
R
E
K
I
F
E
A
L
E
S
A
L
A
T
A
T
K
K
K
Y
E
Q
E
I
D
V
R
V
Q
I
-
D
R
K
S
G
D
F
D
T
F
R
R
W
L
V
V
D
E
V
T
Q
P
T
K
E
I
T
L
E
A
A
-
R
Y
E
D
E
S
L
N
L
G
D
Y
V
E
D
Q
I
E
-
S
V
T
F
D
R
I
T
T
Q
T
A
K
Q
V
I
V
Q
K
V
R
E
A
E
R
A
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
50.73
34%
-40
- C6 -
2KWP
-
NUSA_ECOLI
A:
[1-128]
----------------------------------
M
N
K
E
I
L
A
V
V
E
A
V
S
N
E
K
A
L
-
P
R
E
K
I
F
E
A
L
E
S
A
L
A
T
A
T
K
K
K
Y
E
Q
E
I
D
V
R
V
Q
I
-
D
R
K
S
G
D
F
D
T
F
R
R
W
L
V
V
D
E
V
T
Q
P
T
K
E
I
T
L
E
A
A
-
R
Y
E
D
E
S
L
N
L
G
D
Y
V
E
D
Q
I
E
-
S
V
T
F
D
R
I
T
T
Q
T
A
K
Q
V
I
V
Q
K
V
R
E
A
E
R
A
M
L
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
49.76
21%
-71
- C6 -
2A19
-
IF2A_YEAST
A:
[8-89]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
N
K
Y
P
E
I
D
D
I
V
M
V
N
V
Q
Q
I
A
E
----
M
-----
G
A
Y
V
K
L
---
L
EYD-
N
I
E
---
G
M
I
L
L
-
S
----------S
I
--------------
Q
--
K
L
I
-
R
V
G
K
N
-
D
V
A
V
V
L
R
V
D
K
E
----------
K
G
Y
I
D
L
S
K
R
R
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
43.78
20%
-42
- C6 -
1KL9
1
IF2A_HUMAN
A:
[13-90]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
E
D
V
V
M
V
N
V
R
S
I
A
E
----
M
-----
G
A
Y
V
S
L
LEY
N
----
N
I
E
---
G
M
I
L
L
-
S
E
L
-------------------------------
R
I
G
R
N
-
E
C
V
V
V
I
R
V
D
K
E
----------
K
G
Y
I
D
L
S
K
R
R
V
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
42.85
12%
-42
- C6 -
1Y14
-
RPB7_YEAST
B:
[78-166]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
K
P
F
K
G
E
V
V
D
G
T
V
V
S
C
S
Q
----
H
-----
G
F
E
V
Q
V
---
G
----
P
M
K
---
V
F
V
T
K
-
H
L
M
P
------
Q
D
L
T
F
N
AS
Y
Q
S
S-----
E
--
D
V
I
-
T
I
K
S
R
-
I
R
V
K
I
E
G
C
I
S
Q
V
S
--------
S
I
H
A
I
G
S
I
K
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
42.59
19%
-48
- C6 -
2K4K
-
GS13_BACSU
A:
[6-80]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
G
S
V
Y
T
G
K
V
T
G
L
Q
A
----
Y
-----
G
A
F
V
A
L
D--
E
----
E
T
Q
---
G
L
V
H
I
-
S
E
V
T
HGFVKD
I
----------------
N
--
E
H
L
-
S
V
G
D
E
-
V
Q
V
K
V
L
A
V
D
E
E
----------
K
G
K
I
S
L
S
I
R
A
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
42.09
19%
1
- C1 -
4L8N
3
?
A:
[6-457]
N
T
S
I
C
R
L
G
F
T
Y
D
ISQSKNWGNNKPVIK
S
I
I
P
YS
S
A
E
Q
A
G
I
K
K
Y
D
V
I
E
E
I
N
G
V
P
V
T
E
V
S
V
D
E
I
P
Q
L
L
N
P
A
G
R
N
------
D
V
L
L
T
I
S
N
L
S
S
P
S
K
Q
V
L
V
K
K
D
C
K
K
S
N
A
I
T
E
D
Q
L
A
S
A
Y
A
M
Y
S
L
E
T
T
N
E
Q
E
F
V
C
P
F
K
T
T
V
T
S
D
G
V
D
F
G
N
F
K
T
F
A
F
S
T
I
D
E
N
N
R
K
L
E
T
V
I
N
E
C
I
E
N
E
L
T
K
K
G
L
T
V
D
I
A
K
P
----
D
-----
L
L
I
Q
T
F
---
Y
----
F
F
D
K
N
P
N
Y
L
G
A
-
N
E
K
E
------
P
----------------
T
--
Y
R
Y
N
F
S
H
S
K
M
E
K
F
P
F
L
N
Y
A
A
A
E
A
E
AE
Y
L
L
Q
F
G
I
R
I
I
D
Q
K
D
I
P
G
-----
R
V
L
W
E
C
E
A
N
E
L
L
E
D
S
Y
R
L
D
E
Y
A
R
V
H
V
P
L
M
C
M
QYPYTKYG
R
N
V
P
F
K
V
S
K
K
T
Y
N
Y
TG
I
S
Y
D
IDKLDQV
V
D
V
D
R
N
S
P
A
Y
A
A
-
G
I
R
P
R
D
I
I
E
K
I
G
R
H
K
MD
H
S
A
E
E
F
S
S
A
Y
K
R
F
I
T
N
T
M
QY
R
D
P
K
T
M
F
T
D
A
NGFK
Y
C
M
F
W
D
V
F
K
Y
-
P
Q
I
A
D
A
S
Q
S
S
D
Y
L
P
A
F
S
Y
L
Y
Y
F
A
P
Y
I
N
P
S
G
N
N
A
C
T
F
N
I
K
R
G
K
T
K
L
E
V
I
I
R
P
----------
T
I
R
S
E
V
T
V
E
I
K
-
37
HHSearch
41.77
15%
-13
* C6 *
2CQO
-
NO40_HUMAN
A:
[13-91]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
L
Y
T
I
F
Q
G
E
V
A
M
V
T
D
----
Y
-----
G
A
F
I
K
I
P--
G
C---
R
K
Q
---
G
L
V
H
R
-
T
H
M
S
SCRVDK
P
----------------
S
--
E
I
V
-
D
V
G
D
K
-
V
W
V
K
L
I
G
R
E
M
K
N
D
--------
R
I
K
V
S
L
S
M
K
V
V
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
41.63
18%
-42
- C6 -
2K52
-
A:
[4-73]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
G
K
F
Y
K
G
V
V
T
R
I
E
K
----
Y
-----
G
A
F
I
N
L
N--
E
----
Q
V
R
---
G
L
L
R
P
-
R
D
M
I
------
S
----------------
L
RL
E
N
L
-
N
V
G
D
E
-
I
I
V
Q
A
I
D
V
R
P
E
----------
K
R
E
I
D
F
K
Y
I
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
41.46
13%
-44
- C6 -
2B8K
-
RPB7_YEAST
G:
[79-171]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
P
F
K
G
E
V
V
D
G
T
V
V
S
C
S
Q
----
H
-----
G
F
E
V
Q
V
---
G
----
P
M
K
---
V
F
V
T
K
-
H
L
M
P
------
Q
D
L
T
F
N
AGSNP
P
S
Y
Q
S
S
E
--
D
V
I
-
T
I
K
S
R
-
I
R
V
K
I
E
G
C
I
S
Q
V
S
--------
S
I
H
A
I
G
S
I
K
E
D
Y
L
GAI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
40.38
20%
-20
- C6 -
1JJG
-
?
A:
[30-100]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
G
S
V
H
E
G
I
V
Y
-
F
K
D
----
G
-----
I
F
K
V
R
L
---
L
GYE-
G
H
E
---
C
I
L
L
D
Y
L
N
Y
R
------
Q
D
T
L
D
R
L
----------
K
--
E
R
L
--
V
G
R
V
-
I
K
T
R
V
V
R
A
D
G
L
------------
Y
V
D
L
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------