@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1328: (2016-03-23 )
MNGIIPLWKERGMTSHDCVYKLRKILHTKKVGHTGTLDPEVEGVLPICIGRATKLAEYVTDEGKVYVAEITLGKSTTTEDATGETVNTKELAEISAAELQAALTKLTGKITQIPPMFSAVKVNGKKLYEYARAGIEVERPSRQVDIYSLIRLDGDTALNQSNPTFQLEIACGKGTYIRTLAVMIGELLGYPAHMSKLERTRSGFFKKEDCLTLTEIDEMMQASDSSFLYPLEKGIESMAKLVIEEEVYAKVLNGGLLPTSLFAEVENEPRAALIFKDKLTAIYKPHPEKKDLWKPEKVIELNQA
Atome Classification :
(25 SA)
--.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......--150.......160.......170.......180.......190.......200......-.210-.....--------...220------.-------.---------.----------.....230.......240.......250.......260..-----.-----.-----...270..-.----....280.......290.......300..------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MNGII
P
L
W
K
ERGMT
S
H
D
C
V
Y
K
L
R
K
I
L
H
TKKVGHTGTLDPEVE
G
V
L
P
ICIG
R
A
T
K
L
A
E
Y
VTDEG
K
V
Y
V
A
E
I
T
LGKSTTTEDATGETV
N
T
K
E
L
A
E
I
S
A
A
E
L
Q
A
A
L
T
K
LTGKITQIPP
M
F
S
A
V
KVN
G
K
K
L
Y
E
Y
A
RAG
I
E
VERPSRQ
V
D
I
Y
S
L
--
I
RLDGDTALNQSN
P
T
F
Q
L
E
I
ACGKG
T
Y
I
R
T
L
A
V
M
I
G
E
L
LGY
P
A
H
M
S
K
L
E
R
T
R
SGFFKKE-DC-
L
-
T
L
T
E
I
--------
D
E
M
M
Q
-------A-------S---------D----------SSF
L
Y
P
L
E
K
G
I
E
S
M
A
K
L
V
I
E
E
E
V
Y
A
K
V
LNGGLL
P
T
S
L
F
A
E
-----V-----E-----NEP
R
A
A
L
I
-
F
----KDK
L
T
A
IYKPHPEKKDLWKPE
K
V
I
ELNQA------
27
HHSearch
94.58
35%
-78
- C3 -
1K8W
11
TRUB_ECOLI
A:
[24-325]
--
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
-
T
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
--
L
F
I
R
H
E
G
------
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
-
T
L
E
H
L
--------
R
E
L
V
E
-------
Q
-------
A
E
Q
Q
DIP
A
A
E
L
L
---------
D
P
L
L
M
P
M
D
S
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
G
A
P
------------
L
-----
E
G
L
V
R
V
T
E
G
E
----
N
G
K
F
I
G
M
G
E
I
D
D
E
--
G
R
V
A
P
R
R
L
V
V
E
Y
--------
47
Fugue
92.16
34%
-73
- C3 -
1K8W
11
TRUB_ECOLI
A:
[22-324]
M
D
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
-
V
T
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
--
L
F
I
R
H
E
------
G
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
-
T
L
E
H
L
--------
R
E
L
V
E
-------
Q
-------
A
---------
E
Q
Q
DIP
A
A
E
L
L
D
P
L
L
M
P
M
D
S
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
---
N
P
V
R
T
S
G
-----
A
-----
P
-----
L
E
G
L
V
R
V
T
-
E
----
G
E
N
G
K
F
I
G
M
G
E
I
D
D
E
G
R
V
A
P
R
R
L
V
V
E
---------
32
HHSearch
91.81
35%
-124
- C3 -
2AUS
2
TRUB_PYRAB
C:
[45-303]
--
Q
Y
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
R
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
R
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
------------------
D
V
P
E
D
K
I
R
A
V
M
K
E
F
E
G
E
I
I
Q
R
-----------------------------
T
R
K
V
Y
Y
I
--
E
I
L
E
I
D
G
------
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
A
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
V
-
T
L
H
D
L
--------
V
D
Y
Y
H
-------
F
W
KEDGIE
E
---------
Y
I
---------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
I
W
I
K
D
S
A
V
A
A
V
A
H
G
A
N
L
T
V
P
G
I
V
K
L
N
A
GI
K
-----
K
-----
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
A
M
------------------------
9
PsiBlast_PDB
90.62
30%
-124
- C3 -
2AUS
2
TRUB_PYRAB
C:
[47-301]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
R
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
R
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
R
A
V
M
K
E
F
E
G
E
I
I
Q
R
---------------------------
T
R
K
V
Y
Y
I
E
I
--
L
E
I
D
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
A
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
V
T
L
H
D
L
V
D
Y
Y
H
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
I
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
I
W
I
K
D
S
A
V
A
A
V
A
H
G
A
N
L
T
V
P
G
I
V
K
-----
L
N
A
GIK
K
-----
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
48
Fugue
90.48
31%
-82
- C3 -
1R3E
3
TRUB_THEMA
A:
[1-309]
-M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
-
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
--
W
D
------
V
N
I
E
G
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
--------
A
---
P
-------
E
-------
E
---------
I
----------
E
N
R
I
I
P
L
E
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
E
-----
W
-----
D
-----
G
F
K
K
G
E
V
V
-
R
V
F
NE
E
G
R
L
L
A
L
A
E
A
E
R
N
S
S
F
L
E
T
L
R
K
E
R
V
L
T
L
R
KVFNTR
30
HHSearch
90.20
33%
-115
- C3 -
2APO
2
TRUB_METJA
A:
[65-322]
--
K
Y
G
V
V
V
V
D
K
P
R
G
P
T
S
H
E
V
S
T
W
V
K
K
I
L
N
L
D
K
A
G
H
G
G
T
L
D
P
K
V
T
G
V
L
P
V
A
L
E
R
A
T
K
T
I
P
M
W
H
I
P
P
K
E
Y
V
C
L
M
H
L
H
R
------------------
D
A
S
E
E
D
I
L
R
V
F
K
E
F
T
G
R
I
Y
Q
R
----------------------------
R
I
R
K
I
H
E
L
--
E
L
L
D
K
D
G
------
K
D
V
L
F
R
V
K
C
Q
S
G
T
Y
I
R
K
L
C
E
D
I
G
E
A
L
G
T
S
A
H
M
Q
E
L
R
R
T
K
S
G
C
F
E
E
K
-
D
A
-
V
-
Y
L
Q
D
L
--------
L
D
A
Y
V
F
W
K
EDGD
E
-------
E
---------
E
L
---------
R
R
V
I
K
P
M
E
Y
G
L
R
H
L
K
K
V
V
V
K
D
S
A
V
D
A
I
C
H
G
A
D
V
Y
V
R
G
I
A
K
-----
L
S
K
GIG
K
-----
G
E
T
V
L
V
E
T
-
L
----
K
G
E
A
V
A
V
G
K
A
L
------------------------
31
HHSearch
90.17
32%
-106
- C3 -
3U28
-
CBF5_YEAST
A:
[58-318]
--
S
S
G
V
I
N
L
D
K
P
S
N
P
S
S
H
E
V
V
A
W
I
K
R
I
L
R
C
E
K
T
G
H
S
G
T
L
D
P
K
V
T
G
C
L
I
V
C
I
D
R
A
T
R
L
V
K
S
Q
Q
G
A
G
K
E
Y
V
C
I
V
R
L
H
D
A
L
-----------------
K
D
E
K
D
L
G
R
S
L
E
N
L
T
G
A
L
F
Q
R
P
P
-----
K
R
Q
-----------------
L
R
V
R
T
I
Y
E
S
--
N
L
I
E
F
D
N
----
K
R
N
L
G
V
F
W
A
S
C
E
A
G
T
Y
M
R
T
L
C
V
H
L
G
M
L
L
G
V
G
G
H
M
Q
E
L
R
R
V
R
S
G
A
L
S
E
N
D
N
M
-
V
-
T
L
H
D
V
--------
M
D
A
Q
W
-------
V
Y
D
N
TRDE
S
---------
Y
L
---------
R
S
I
I
Q
P
L
E
T
L
L
V
G
Y
K
R
I
V
V
K
D
S
A
V
N
A
V
C
Y
G
A
K
L
M
I
P
G
L
L
R
-----
Y
E
E
GIE
L
-----
Y
D
E
I
V
L
I
T
-
T
----
K
G
E
A
I
A
V
A
I
A
-------------------------
28
HHSearch
89.60
33%
-88
* C3 *
1R3E
3
TRUB_THEMA
A:
[2-286]
--
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
-
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
--
W
D
V
N
I
E
G
------
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
V
F
E
A
--------
A
P
E
E
I
------------------------------------
E
N
R
I
I
P
L
E
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
E
-----
W
DGFK-
K
-----
G
E
V
V
R
V
F
N
-
E
----
E
G
R
L
L
A
L
A
E
A
E
R
-----------------------
14
PsiBlast_PDB
88.13
29%
-118
- C3 -
3LWP
1
TRUB_PYRFU
A:
[47-301]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
----------
L
R
---------------
T
R
K
V
Y
Y
I
E
V
--
L
E
I
E
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
D
Y
Y
Y
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
F
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
G
I
A
K
-----
L
-----
H
A
GIKR
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
13
PsiBlast_PDB
88.08
29%
-116
- C3 -
3LWO
1
TRUB_PYRFU
A:
[47-301]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
----------
L
R
---------------
T
R
K
V
Y
Y
I
E
V
--
L
E
I
E
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
D
Y
Y
Y
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
F
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
G
I
A
K
-----
L
-----
H
A
GIKR
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
17
PsiBlast_PDB
87.38
29%
-117
- C3 -
3LWV
1
TRUB_PYRFU
A:
[47-301]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
----------
L
R
---------------
T
R
K
V
Y
Y
I
E
V
--
L
E
I
E
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
D
Y
Y
Y
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
F
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
G
I
A
K
-----
L
-----
H
A
GIKR
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
16
PsiBlast_PDB
86.72
29%
-117
- C3 -
3LWR
1
TRUB_PYRFU
A:
[47-301]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
----------
L
R
---------------
T
R
K
V
Y
Y
I
E
V
--
L
E
I
E
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
D
Y
Y
Y
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
F
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
G
I
A
K
-----
L
-----
H
A
GIKR
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
11
PsiBlast_PDB
86.44
29%
-113
- C3 -
3HAX
5
TRUB_PYRFU
A:
[47-301]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
R
R
L
R
---------------
T
R
K
V
Y
Y
I
E
V
--
L
E
I
E
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
D
Y
Y
Y
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
F
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
G
I
A
K
-----
L
-----
H
A
GIKR
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
15
PsiBlast_PDB
86.33
29%
-114
- C3 -
3LWQ
1
TRUB_PYRFU
A:
[47-301]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
----------
L
R
---------------
T
R
K
V
Y
Y
I
E
V
--
L
E
I
E
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
D
Y
Y
Y
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
F
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
G
I
A
K
-----
L
-----
H
A
GIKR
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
18
PsiBlast_PDB
86.15
30%
-114
- C3 -
2EY4
-
TRUB_PYRFU
A:
[47-301]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
---
R
R
L
R
------------
T
R
K
V
Y
Y
I
E
V
--
L
E
I
E
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
D
Y
Y
Y
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
F
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
G
I
A
K
-----
L
-----
H
A
GIKR
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
10
PsiBlast_PDB
86.13
29%
-117
- C3 -
2HVY
1
TRUB_PYRFU
A:
[47-301]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
-------
L
R
---------------
T
R
K
V
Y
Y
I
E
V
--
L
E
I
E
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
D
Y
Y
Y
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
F
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
G
I
A
K
-----
L
-----
H
A
GIKR
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
19
PsiBlast_PDB
86.02
29%
-117
- C3 -
3MQK
2
TRUB_PYRFU
A:
[40-294]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
R
R
L
R
---------------
T
R
K
V
Y
Y
I
E
V
--
L
E
I
E
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
D
Y
Y
Y
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
F
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
G
I
A
K
-----
L
-----
H
A
GIKR
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
20
PsiBlast_PDB
85.54
29%
-113
- C3 -
3HJW
2
TRUB_PYRFU
A:
[40-294]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
R
R
L
R
---------------
T
R
K
V
Y
Y
I
E
V
--
L
E
I
E
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
D
Y
Y
Y
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
F
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
G
I
A
K
-----
L
-----
H
A
GIKR
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
7
PsiBlast_PDB
85.10
34%
-77
- C3 -
1ZE2
2
TRUB_THEMA
A:
[3-263]
---
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
-
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
------
W
D
V
N
I
E
G
R
D
V
S
F
R
V
E
V
S
--
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
---
V
--------
F
E
A
A
P
-------
E
-------
E
---------
I
----------
E
N
R
I
I
P
L
E
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
E
------------------------------------------------------------------
12
PsiBlast_PDB
85.05
29%
-107
- C3 -
3HAY
1
TRUB_PYRFU
A:
[47-301]
----
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
------------------
G
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
R
R
L
R
---------------
T
R
K
V
Y
Y
I
E
V
--
L
E
I
E
G
R
D
V
L
--------
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
-
L
I
T
L
H
D
L
V
D
Y
Y
Y
F
W
K
E
D
G
I
E
-------
E
-------
Y
---------
F
----------
R
K
A
I
Q
P
M
E
K
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
G
I
A
K
-----
L
-----
H
A
GIKR
G
D
L
V
A
I
M
T
-
L
----
K
D
E
L
V
A
L
G
K
--------------------------
2
PsiBlast_PDB
84.50
42%
-80
- C3 -
1K8W
8
TRUB_ECOLI
A:
[24-240]
--
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
T
-
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
LF
I
R
H
E
G
N
--------
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
-
T
L
E
H
L
--------
R
E
L
V
E
-------
Q
-------
A
---------
E
--------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.24
42%
-80
- C3 -
1ZL3
3
TRUB_ECOLI
A:
[24-240]
--
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
N
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
T
-
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
LF
I
R
H
E
G
N
--------
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
-
T
L
E
H
L
--------
R
E
L
V
E
-------
Q
-------
A
---------
E
--------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.10
34%
-76
- C3 -
1R3E
3
TRUB_THEMA
A:
[3-259]
---
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
-
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
------
W
D
V
N
I
E
G
R
D
V
S
F
R
V
E
V
S
--
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
---
V
--------
F
E
A
A
P
-------
E
-------
E
---------
I
----------
E
N
R
I
I
P
L
E
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
E
------------------------------------------------------------------
8
PsiBlast_PDB
83.62
34%
-76
- C3 -
2AB4
2
TRUB_THEMA
A:
[3-263]
---
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
F
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
-
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
------
W
D
V
N
I
E
G
R
D
V
S
F
R
V
E
V
S
--
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
---
V
--------
F
E
A
A
P
-------
E
-------
E
---------
I
----------
E
N
R
I
I
P
L
E
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
E
------------------------------------------------------------------
24
PsiBlast_CBE
67.07
34%
-64
- C3 -
1ZE2
2
TRUB_THEMA
B:
[3-274]
---
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
-----------------------------------------
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
------------------
R
V
E
V
S
--
P
G
T
Y
I
R
-------------------
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
-
N
---
V
--------
F
E
A
A
P
-------
E
-------
E
---------
I
----------
E
N
R
I
I
P
L
E
K
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
E
------------------------------------------------------------------