@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1378: (2016-03-24 )
MTTSPFSLKSRSLKFKWTFGASAAIFLTFFLFSYAIYQGIGQMLLNEEEPEVKELLLATTSTLTNQDLTDNEEIKYLFNNDKTVNRKLQDQVINLYDKDGHFINKYYFSRSQDITSIDFSQYFVSGTDKFIMNKPTIDGQKMMTAQMPIVADDNTTVIGYAQVVNPLTSYNRMMDRLLVTMILLGAVALFISGMLGYLLAQNFLNPLTRLARTMNDIRKNGFQKRIETKTNSRDEIGELTVVFNDMMTRIETSFEQQKQFVEDASHELRTPVQIMEGHLKLLTRWGKDDPAVLDESLNASLTELERMKKLVQEMLDLSRAEQISQTKELQITDVNATVEQVRRNFEVMYENFTFTLKEDDTDLRALIQHNHLEQILIIIMDNAVKYSGDGTEVDMHVYKEQKQIHIDVRDYGEGISQEEIDKIFNRFYRVDKARSREKGGNGLGLAIAKQLVEGYLGTINAVSEPDKGTTIKITLPYIEPKSK
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....-..120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250-----.........260.......270.......280.-...----..------..290....-----...300.--......310.......320---.----..---...----..-----330..--..-...-340..--.....350--...----------......--360-------------.......--.370.......380......-.390------..--......--400.--......410.......420.......430--.......440.......450.......460.......470.......480.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTTSPFSLKSR
S
L
K
F
K
W
TFGA
S
A
A
I
F
L
T
F
F
L
F
S
Y
A
I
Y
Q
G
I
G
Q
M
LLNEEEP
E
V
K
E
L
L
L
A
TTSTLTNQDLTDNE
E
I
K
Y
L
FNND
K
T
V
N
R
K
L
Q
D
Q
V
I
N
L
YDKDG
H
F
I
N
K
YYFSRSQDITSI-
D
F
S
Q
Y
F
VSGTD
K
F
I
MNKPTIDGQ
K
M
M
T
AQM
P
I
V
ADDN
T
T
V
I
G
Y
A
Q
V
V
N
P
L
T
S
Y
N
R
M
M
D
R
L
L
V
T
M
I
L
L
G
A
V
A
L
F
I
S
G
M
L
G
Y
L
L
A
Q
N
F
L
N
P
L
T
R
L
A
R
T
M
N
D
I
R
K
N
G
F
Q
K
R
I
ETKTNSRDEIGE
L
T
V
V
F
N
D
M
M
T
R
I
-------
E
T
S
F
E
Q
Q
K
Q
F
V
E
D
A
S
H
E
LR
T
P
V
Q
I
M
E
G
H
L
K
-
L
L
-
T
R
W----GK------D
D
P
A
V
L
D
E
S-----L
N
A
S
L
T
E
--
L
E
R
M
K
K
L
V
Q
E
M
L
D
L
S
R
A
E
----
Q
----IS---QTK----
E
L
-----
Q
I
TD
V
--
N
A
-
T
V
E
-
Q
V
R
R
N
--
F
E
V
MYE----N
F
T
----------
F
T
LKED--D
T
--------------
D
L
R
A
L
I
Q
--
H
N
H
L
E
Q
I
L
I
I
I
MDN
A
V
K
YSG-DG
T
-------
E
V
--
D
M
H
V
Y
K
--E
Q
K
Q
--
I
H
I
D
V
R
D
YGEGI
S
Q
E
E
I
D
K
I
F
N
R
F
Y
R
V
D
K
--ARSREKGGNG
L
G
L
A
I
A
K
Q
L
V
E
G
Y
L
G
T
INAVSEPDKG
T
T
I
K
I
T
L
PYIEPKSK
2
PsiBlast_PDB
88.11
35%
-85
- C3 -
4U7O
1
?
A:
[35-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
-
A
L
-
S
D
G
----
A
W
------
K
D
P
E
V
A
P
G
F
-----
L
K
V
T
Q
E
E
--
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
----
S
----
G
T
---
T
R
V
----
D
M
-----
E
L
V
N
I
--
N
E
-
M
----------
F
N
Y
V
L
D
----
R
F
D
----------
M
I
L
K
K
D
--
D
N
PA
K
Y
Y
T
I
K
R
E
F
T
K
R
D
L
W
V
E
I
D
--
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
-
D
G
G
-------
V
V
--
T
C
R
L
L
E
--
T
H
N
Q
--
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-------
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
-
E
----
9
PsiBlast_PDB
85.37
29%
-51
- C3 -
4BIV
2
CPXA_ECOLI
A:
[30-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
R
K
L
K
N
A
A
D
E
V
A
Q
G
N
L
R
Q
H
P
E
L
E
A
G
P
Q
E
F
L
A
-
A
G
A
S
F
N
Q
M
V
T
A
L
-------
E
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
-
L
L
-
R
R
R
----
S
G
------
E
S
-----
K
E
-----
L
E
R
I
E
T
E
--
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
----
Q
K
N
A
L
V
S
---
E
T
--------------
I
K
A
--
N
Q
-
L
W
S
-
E
V
L
D
N
A
A
F
E
A
E
Q
M
----
G
K
S
----------
L
T
V
N
F
P
--
P
G
--------------
P
W
P
L
Y
G
N
--
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
-
T
K
I
-------
E
V
--
G
F
A
V
D
K
--
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
--
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
-------
1
PsiBlast_PDB
84.37
35%
-85
- C3 -
4U7N
-
?
A:
[39-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
-
A
L
-
S
D
G
----
A
W
------
K
D
P
E
V
A
P
G
F
-----
L
K
V
T
Q
E
E
--
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
----
S
----
G
T
---
T
R
V
----
D
M
-----
E
L
V
N
I
--
N
E
-
M
----------
F
N
Y
V
L
D
----
R
F
D
----------
M
I
L
K
K
D
--
D
N
Y
Y
T
I
K
R
E
F
T
KR---
D
L
W
V
E
I
D
--
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
-
D
G
G
-------
V
V
--
T
C
R
L
L
E
--
T
H
N
Q
--
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-------------
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
-
E
----
21
PsiBlast_CBE
83.93
35%
-68
- C3 -
4U7O
1
?
B:
[37-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
-
A
L
-
S
D
G
----
A
W
------
K
D
P
E
V
A
P
G
F
-----
L
K
V
T
Q
E
E
--
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
-----------------
T
R
V
----
D
M
-----
E
L
V
N
I
--
N
E
-
M
----------
F
N
Y
V
L
D
----
R
F
D
----------
M
I
L
K
K
D
--
D
N
PAKY
Y
T
I
K
R
E
F
T
K
R
D
L
W
V
E
I
D
--
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
-
D
G
G
-------
V
V
--
T
C
R
L
L
E
--
T
H
N
Q
--
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
--
A
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
-
E
----
10
PsiBlast_PDB
82.94
29%
-55
- C3 -
4CB0
6
CPXA_ECOLI
A:
[57-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
F
L
A
-
A
G
A
S
F
N
Q
M
V
T
A
L
-------
E
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
-
L
L
-
R
R
R
----
S
G
------
E
S
-----
K
E
-----
L
E
R
I
E
T
E
--
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
----
Q
K
N
AL
V
S
---
E
T
--------------
I
K
A
--
N
Q
-
L
W
S
-
E
V
L
D
N
A
A
F
E
A
E
Q
M
----
G
K
S
----------
L
T
V
N
F
P
--
P
G
--------------
P
W
P
L
Y
G
N
--
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
-
T
K
I
-------
E
V
--
G
F
A
V
D
K
--
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
--
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
-------
58
Fugue
82.54
26%
-40
* C4 *
4I5S
-
?
A:
[37-432]
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
---------------------
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
-
T
D
R
S
G
K
------------
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
---------------------------------------------------
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
I
S
G
L
I
A
V
L
H
D
A
-
T
E
Q
-------
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
-
A
L
-
D
D
-----
G
A
------
L
T
E
S
V
A
P
S
F
-----
I
K
V
S
L
D
E
--
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
H
----
L
----------------
D
V
-----
E
L
T
N
F
--
T
A
-
F
M
N
-
Y
I
L
D
R
--
F
D
Q
I
Q
S
----
Q
Q
S
----------
T
E
I
I
R
D
YP
D
K
--------------
S
V
W
I
E
I
D
--
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
-
D
G
G
-------
K
V
--
T
I
T
M
Q
T
--
T
D
T
Q
--
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
--
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
-------
36
HHSearch
80.97
17%
-52
- C3 -
2E0A
2
PDK4_HUMAN
A:
[65-353]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
S
V
Q
L
V
K
S
W
Y
I
Q
S
L
M
D
L
V
E
F
HEKS
P
D
D
Q
K
A
L
S
D
F
V
D
T
L
I
K
V
R
N
R
H
H
N
V
V
P
T
M
A
Q
-
G
I
-
I
E
Y
----
K
D
A
C
T
V
D
P
V
T
N
Q
N
L
Q
Y
F
-----
L
D
R
F
Y
M
N
R
I
S
T
R
M
L
-
M
N
Q
H
I
L
I
F
S
D
S
Q
----
T
----
G
N
PSH
I
G
S
----
I
D
-----
P
N
C
D
V
--
V
A
-
V
V
Q
-
D
A
F
E
C
--
S
R
M
L
C
D
----
Q
Y
Y
L
S
S
P
E
L
K
L
T
Q
V
N
G
K
F
P
--
D
Q
--------------
P
I
H
I
V
Y
V
--
P
S
H
L
H
H
M
L
F
E
L
F
K
N
A
M
R
A
T
V
-
E
H
Q
E
NQP
S
L
T
P
I
--
E
V
I
V
V
L
--
G
K
E
D
--
L
T
I
K
I
S
D
R
G
G
G
V
P
L
R
I
I
D
R
L
F
S
Y
T
Y
S
T
A
P
TP--
N
A
P
L
A
G
F
G
Y
G
L
P
I
S
R
L
Y
A
K
Y
F
Q
G
D
L
N
L
Y
S
L
S
G
Y
G
T
D
A
I
I
Y
L
K
A
L
S
S
E
--
5
PsiBlast_PDB
79.04
28%
-41
- C3 -
4BIW
5
CPXA_ECOLI
A:
[52-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
G
P
Q
E
F
L
A
A
-
G
A
S
F
N
Q
V
V
T
A
L
-------
E
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
-
L
L
-
R
R
R
----
S
G
------
E
S
-----
K
E
-----
L
E
R
I
E
T
E
--
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
----
Q
KN
A
L
V
S
---
E
T
I
----
K
A
NQLW
S
E
V
L
D
N
--
A
A
F
E
A
E
-
Q
M
G
K
S
--
L
T
V
N
F
P
----
P
G
P
----------
W
P
L
Y
G
N
--
P
-------------------------
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
-
T
K
I
-------
E
V
--
G
F
A
V
D
K
--
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
--
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
-------
17
PsiBlast_PDB
78.85
28%
-58
- C3 -
4Q20
-
DIVL_CAUCR
A:
[40-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
D
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
-
L
L
-
E
R
A
DS
E
R
G
R
------
N
H
V
A
----
A
-----
V
R
A
A
A
T
Q
--
L
A
R
S
I
D
D
V
L
D
M
A
Q
I
D
A
G
E
----
M
----
A
L
---
E
I
E
----
D
I
-----
R
V
S
D
L
L
L
N
A
-
Q
-
E
-
R
A
L
K
D
--
A
Q
L
G
G
V
----
T
L
A
----------
V
E
C
E
E
D
--
V
G
--------------
L
I
R
G
--
D
--
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
P
-
P
G
G
-------
R
V
--
T
L
S
A
R
R
--
A
L
G
E
--
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
--------
G
R
D
R
G
G
P
G
L
G
L
A
L
V
K
A
L
V
E
L
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
-------
22
PsiBlast_CBE
78.11
32%
-62
- C3 -
4JAV
6
?
B:
[22-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
-
N
S
L
----
G
E
------
L
D
L
S
T
L
K
E
F
-----
L
E
V
I
I
D
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
KS
L
Q
----
I
N
---
R
E
K
VD
L
C
D
L
-----
V
E
S
A
V
--
N
A
-
I
K
E
F
A
S
S
H
N
--
V
N
V
L
F
E
----
S
N
V
------------------
P
C
--------------
P
V
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
-------
D
K
--
Y
V
K
V
I
L
--
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-------
13
PsiBlast_PDB
77.50
32%
-73
- C3 -
2C2A
2
?
A:
[22-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
-
N
S
L
----
G
E
------
L
D
L
S
T
L
K
E
F
-----
L
E
V
I
I
D
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
KS
L
Q
----
I
N
---
R
E
K
VD
L
C
D
L
-----
V
E
S
A
V
--
N
A
-
I
K
E
F
A
S
S
H
N
--
V
N
V
L
F
E
----
S
N
V
------------------
P
C
--------------
P
V
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
-------
D
K
--
Y
V
K
V
I
L
--
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
-----------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-------
15
PsiBlast_PDB
76.86
32%
-61
- C3 -
4JAV
6
?
A:
[22-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
-
N
S
L
----
G
E
------
L
D
L
S
T
L
K
E
F
-----
L
E
V
I
I
D
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
----
I
N
---
R
E
K
VD
L
C
D
L
-----
V
E
S
A
V
--
N
A
-
I
K
E
F
A
S
S
H
N
--
V
N
V
L
F
E
----
S
N
V
------------------
P
C
--------------
P
V
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
-------
D
K
--
Y
V
K
V
I
L
--
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-------
11
PsiBlast_PDB
76.47
32%
-59
- C3 -
4JAS
2
?
A:
[22-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
-
M
I
Y
N
S
L
----
G
E
------
L
D
L
S
T
L
K
E
F
-----
L
E
T
I
I
E
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
----
I
N
---
R
E
K
VD
L
C
D
L
-----
V
E
S
A
V
--
N
A
-
I
K
E
F
A
S
S
H
N
--
V
N
V
L
F
E
----
S
N
V
------------------
P
C
--------------
P
V
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
-------
D
K
--
Y
V
K
V
I
L
--
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-------
3
PsiBlast_PDB
76.47
35%
-62
- C3 -
4I5S
-
?
A:
[211-432]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
-
A
L
-----------------
D
D
G
A
L
T
E
S
V
A
P
S
F
I
K
V
S
L
D
E
--
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
----------------
S
H
L
----
D
V
-----
E
L
T
N
F
--
T
A
-
F
M
N
-
Y
I
L
D
R
--
F
D
Q
I
Q
S
QQST--------------
E
I
I
R
D
--
Y
P
--------------
D
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
-
D
G
G
-------
K
V
--
T
I
T
M
Q
T
--
T
D
T
Q
--
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
--
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
-------
14
PsiBlast_PDB
76.13
32%
-55
- C3 -
3DGE
3
?
A:
[22-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
-
N
S
L
----
G
E
------
L
D
L
S
T
L
K
E
F
-----
L
E
V
I
I
D
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
KS
L
Q
----
I
N
---
R
E
K
VD
L
C
D
L
-----
V
E
S
A
V
--
N
A
-
I
K
E
F
A
S
S
H
N
--
V
N
V
L
F
E
----
S
N
V
------------------
P
C
--------------
P
V
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
-------
D
K
--
Y
V
K
V
I
L
--
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-------
12
PsiBlast_PDB
75.97
32%
-70
- C3 -
4JAU
1
?
A:
[22-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
-
M
I
Y
N
S
L
----
G
E
------
L
D
L
S
T
L
K
E
F
-----
L
E
T
I
I
E
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
KS
L
Q
----
I
N
---
R
E
K
VD
L
C
D
L
-----
V
E
S
A
V
--
N
A
-
I
K
E
F
A
S
S
H
N
--
V
N
V
L
F
E
----
S
N
V
------------------
P
C
--------------
P
V
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
-------
D
K
--
Y
V
K
V
I
L
--
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
-----------
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-------
23
PsiBlast_CBE
75.64
32%
-56
- C3 -
3DGE
2
?
B:
[22-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
-
N
S
L
----
G
E
------
L
D
L
S
T
L
K
E
F
-----
L
E
V
I
I
D
Q
--
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
RKSL
Q
----
I
N
---
R
E
K
VDLC
D
L
-----
V
E
S
A
V
--
N
A
-
I
K
E
F
A
S
S
H
N
--
V
N
V
L
F
E
----
S
N
V
------------------
P
C
--------------
P
V
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
-------
D
K
--
Y
V
K
V
I
L
--
D
E
K
D
GG
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
-------
8
PsiBlast_PDB
75.35
28%
-45
- C3 -
4BIZ
3
CPXA_ECOLI
A:
[62-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
G
A
S
F
N
Q
M
V
T
A
L
-------
E
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
E
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
-
L
L
-
R
R
R
----
S
G
------
E
S
-----
K
E
-----
L
E
R
I
E
T
E
--
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
----
Q
K
N
AL
V
S
---
E
T
I
----
K
A
NQLW
S
E
V
L
D
N
--
A
A
F
E
A
E
-
Q
M
G
K
S
--
L
T
V
N
F
P
----
P
G
P
----------
W
P
L
Y
G
N
--
P
-------------------------
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
-
T
K
I
-------
E
V
--
G
F
A
V
D
K
--
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
--
A
R
D
R
E
--
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
-------
6
PsiBlast_PDB
74.59
28%
-54
- C3 -
4BIX
3
CPXA_ECOLI
A:
[61-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
-
G
A
S
F
N
Q
V
V
T
A
L
-------
E
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
-
L
L
-
R
R
R
----
S
G
------
E
S
-----
K
E
-----
L
E
R
I
E
T
E
--
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
----
Q
KNAL
V
S
---
E
T
I
----
K
A
NQLW
S
E
V
L
D
N
--
A
A
F
E
A
E
-
Q
M
G
K
S
--
L
T
V
N
F
P
----
P
G
P
----------
W
P
L
Y
G
N
--
P
-------------------------
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
-
T
K
I
-------
E
V
--
G
F
A
V
D
K
--
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
----------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
-------
7
PsiBlast_PDB
73.53
28%
-50
- C3 -
4BIY
3
CPXA_ECOLI
A:
[61-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
-
G
A
S
F
N
Q
V
V
T
A
L
-------
E
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
-
L
L
-
R
R
R
----
S
G
------
E
S
-----
K
E
-----
L
E
R
I
E
T
E
--
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
----
Q
KNAL
V
S
---
E
T
I
----
K
A
NQLW
S
E
V
L
D
N
--
A
A
F
E
A
E
-
Q
M
G
K
S
--
L
T
V
N
F
P
----
P
G
P
----------
W
P
L
Y
G
N
--
P
-------------------------
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
-
T
K
I
-------
E
V
--
G
F
A
V
D
K
--
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
-----------
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
-------
45
HHSearch
69.02
42%
-78
* C3 *
3SL2
2
A:
[3-153]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
I
--
V
R
-
F
M
S
-
L
I
I
D
R
--
F
E
M
T
K
E
Q-----
E
----------
F
I
R
N
L
P
--
D
R
--------------
D
L
Y
V
E
I
D
--
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
-
E
G
G
-------
H
V
--
T
F
S
I
D
V
NE
E
E
E
L
--
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
--------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
E
----
4
PsiBlast_PDB
63.49
48%
-74
- C3 -
3SL2
2
A:
[32-153]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
--------------
D
L
Y
V
E
I
D
--
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
-
E
G
G
-------
H
V
T
F
S
I
D
V
N
E
--
E
E
E
L
--
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
--------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
E
----