@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1403: (2016-03-24 )
MTEYTPMIKQYLEIKDKYQDAFLFFRLGDFYEMFFEDALNASQILEITLTGREGGTKEKIPMCGVPYHSASGYIDTLIEKGYKVAICEQVEDPKTTKGMVKREVVQLISPGTVMDERGLKAKENNYIASLYCYEGKEYGFAYSDLSTGELKSTVIEASEDRLINELTTLSTRELIVSSSEKEVLSDVMKEQLGLTFSVHEEDTIPAENEKLVTRHMSLSEKRAIGKLLHYLKETQKRDLGHLQQAVHYETSNYMKMDYYSKRNLELAESIRGKGRQGTLLWLLDNTQTAMGGRMLKQWIDRPLIDRKKIIERQNDVSELMAHFFERLELVENLKNVYDLERLAGRVAYGNVNARDLIQLRNSLYQIPRIRATLLSMSSESLTELAEQLDPCEELTEKLEEAIMDSAPISIREGGIIKDGYNSQLDTYRDASRNGKTWIAELERKERELTGIKTLKVGFNRVFGYYIEVTRANTHLLPEGRYERKQTLTNAERYITPELKEKEKLILDAEEKSMELEYQLFSEVREMVKDYIERLQKLAKSVSEIDCLQSFADISEKNHFIRPTLSEDGSLHVKQGRHPVVEKVMGAQSYVANDCDLDENREILLITGPNMSGKSTYMRQVALTAICAQVGCFVPAEEAILPIFDQIFTRIGAADDLIAGQSTFMVEMLEARNAIVHATKDSLILFDEIGRGTATYDGMALAQAIIEYIHENVHAKTLFSTHYHELTDLEKELRGLQNIHVSAVEENGKVVFLHKIKEGPADKSYGIHVAELAELPKSLIERASRILEQLENDDKKIIIASVKQPEEVHEEVQLSMFPLEPEKKASSKETKLLKEIASMNIMQMTPMDAMNKLYELQSKIH
Atome Classification :
(28 SA)
.........10........20........30........40........50.......-.60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170......--.--180..-----------------.---------------....190.......200......-.210...--------.----...220........230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
E
Y
T
P
M
I
K
Q
Y
L
E
I
K
D
K
YQ
D
A
F
L
F
F
R
L
G
D
F
Y
E
M
F
F
E
DAL
N
A
S
Q
I
L
E
I
T
L
TGREGGTKE-KIPMCGVPYHSAS
G
Y
I
D
T
L
I
EKG
Y
K
V
A
I
C
EQVEDPKT
T
K
G
M
V
K
R
E
V
V
Q
LISPGTVMDERGLKAKEN
N
Y
I
A
S
L
Y
C
YEGKEY
G
F
A
YSDLST
G
E
L
K
S
T
V
I
EAS
E
D
R
L
I
N
E
L
T
TL
S
T
R
E
L
IVSS--S--
E
K
E
V
L
-----------------
S
---------------
D
V
M
K
E
QLG
L
T
F
S
VHEEDTIPAE
N
-
E
K
L
V
T
R
H
--------M----S
L
S
E
-
K
R
A
I
G
K
L
L
H
Y
L
K
E
T
Q
K
R
D
L
G
H
L
Q
Q
A
V
HYETSN
Y
M
K
M
D
Y
YSKRN
L
E
L
A
E
S
I
RGKGRQ
G
T
L
L
W
L
LDNT
Q
T
A
M
G
G
R
M
L
K
Q
W
IDRPLI
D
R
K
K
I
I
E
R
QN
D
V
S
E
L
M
A
H
F
F
E
R
L
E
L
V
E
N
L
K
N
V
Y
D
L
E
R
L
A
G
R
VAYGNV
N
A
R
D
L
I
Q
L
R
N
S
L
Y
QI
P
R
I
R
A
T
L
L
SM
S
S
E
S
L
T
E
L
A
E
QLD
P
C
E
E
L
T
E
K
L
E
E
A
I
MDSAP
I
S
I
REG
G
I
IKDGYNSQ
L
D
T
YRDASRNG
K
T
W
I
A
E
L
E
R
K
E
R
E
LTG
I
K
T
L
K
V
G
F
N
R
V
F
G
Y
Y
I
E
V
TRANTHLLPEGR
Y
E
R
K
Q
TLTN
A
E
RYITPELK
E
K
E
K
L
I
LDAEEKS
M
E
L
E
Y
Q
L
F
S
E
V
R
E
M
V
K
D
Y
I
E
R
L
Q
K
L
A
K
S
V
S
E
I
D
C
L
Q
S
F
A
D
I
SEKN
H
F
IRPTLSEDG
S
L
H
VKQGR
H
P
V
V
E
K
V
MGAQSYVANDCDLDEN
R
E
I
L
L
I
TGPNMSG
K
S
T
Y
M
R
Q
V
A
L
T
A
I
C
A
Q
VGCFV
P
A
E
E
A
I
L
P
I
F
D
Q
I
F
T
RIGAADDLIAG
Q
S
T
F
M
V
E
M
L
E
AR
N
A
I
V
HATKD
S
L
I
L
F
DEIGRGTATY
D
G
M
A
L
A
Q
A
I
I
E
Y
I
H
ENVH
A
K
T
L
F
S
T
H
Y
H
E
L
T
D
L
E
K
E
L
R
G
L
Q
N
I
H
V
S
A
VEEN
G
K
V
V
F
L
H
KIKEGPADKSYG
I
H
V
A
E
L
A
E
L
P
K
S
L
I
E
R
A
S
R
I
L
E
Q
L
ENDD
K
K
I
I
I
A
SVK
Q
P
E
E
V
H
E
E
V
Q
L
S
MFPLEPEKKAS
S
K
E
T
K
L
L
K
E
I
A
SMN
I
M
QMT
P
M
D
A
M
N
K
L
Y
E
L
Q
SKIH
8
PsiBlast_PDB
97.70
40%
-81
- C2 -
3K0S
3
MUTS_ECOLI
A:
[9-797]
---
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
------------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
N
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
11
PsiBlast_PDB
97.50
39%
-81
- C2 -
1E3M
5
MUTS_ECOLI
A:
[10-798]
---
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
DF
A
--
E
M
S
L
I
-----------------
E
GRRG
L
R
R
R
P
LWEFE
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
5
PsiBlast_PDB
97.06
40%
-81
- C2 -
2WTU
5
MUTS_ECOLI
A:
[10-798]
---
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
A
A
D
--------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
9
PsiBlast_PDB
96.92
40%
-80
- C2 -
1WBB
4
MUTS_ECOLI
A:
[10-798]
---
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
A
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
7
PsiBlast_PDB
96.75
40%
-80
- C2 -
1WBD
4
MUTS_ECOLI
A:
[10-798]
---
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
Q
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
3
PsiBlast_PDB
96.70
40%
-78
- C2 -
1OH7
4
MUTS_ECOLI
A:
[10-798]
---
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
10
PsiBlast_PDB
96.67
40%
-79
- C2 -
1WB9
4
MUTS_ECOLI
A:
[10-798]
---
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
T
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
12
PsiBlast_PDB
96.54
40%
-82
- C2 -
1NNE
7
MUTS_THEAQ
A:
[15-762]
-----
P
L
L
Q
Q
Y
V
E
L
R
D
Q
Y
P
D
Y
L
L
L
F
Q
V
G
D
F
Y
E
C
F
G
E
D
A
E
R
L
A
R
A
L
G
L
V
L
T
H
K
T
--
S
K
D
F
T
T
P
M
A
G
I
P
L
R
A
F
E
A
Y
A
E
R
L
L
K
M
G
F
R
L
A
V
A
D
Q
V
E
P
A
E
E
A
E
G
L
V
R
R
E
V
T
Q
L
L
T
P
G
T
L
L
Q
E
-
S
L
L
P
R
E
A
N
Y
L
A
A
I
A
T
G
D
G
--
W
G
L
A
F
L
D
V
S
T
G
E
F
K
G
T
V
L
K
-
S
K
S
A
L
Y
D
E
L
F
R
H
R
P
A
E
V
L
L
A
P
--
E
L
L
E
N
G
A
F
-----------------
L
---------------
D
E
F
R
K
R
F
P
V
M
L
S
---
E
A
P
F
E
P
E
G
-
E
G
------------------
P
L
A
L
-
R
R
A
R
G
A
L
L
A
Y
A
Q
R
T
Q
G
G
A
L
-
S
L
Q
P
F
R
F
Y
D
P
G
A
F
M
R
L
P
E
A
T
L
R
A
L
E
V
F
E
P
L
R
G
---
Q
D
T
L
F
S
V
L
D
E
T
R
T
A
P
G
R
R
L
L
Q
S
W
L
R
H
P
L
L
D
R
G
P
L
E
A
R
L
D
R
V
E
G
F
V
R
E
G
A
L
R
E
G
V
R
R
L
L
Y
R
L
A
D
L
E
R
L
A
T
R
L
E
L
G
R
A
S
P
K
D
L
G
A
L
R
R
S
L
Q
I
L
P
E
L
R
A
L
L
----
G
E
E
V
G
-----
L
P
D
L
S
P
L
K
E
E
L
E
A
A
L
V
E
D
P
P
L
K
V
S
E
G
G
L
I
R
E
G
Y
D
P
D
L
D
A
L
R
A
A
H
R
E
G
V
A
Y
F
L
E
L
E
E
R
E
R
E
R
T
G
I
P
T
L
K
V
G
Y
N
A
V
F
G
Y
Y
L
E
V
T
R
P
Y
Y
E
R
V
P
K
-
E
Y
R
P
V
Q
T
L
K
D
R
Q
R
Y
T
L
P
E
M
K
E
K
E
R
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
A
A
L
A
E
V
A
V
R
Y
G
Y
V
R
P
R
F
G
D
--
R
L
Q
I
R
A
G
R
H
P
V
V
E
R
---
R
T
E
F
V
P
N
D
L
E
M
--
A
H
E
L
V
L
I
T
G
P
N
M
A
G
K
S
T
F
L
R
Q
T
A
L
I
A
L
L
A
Q
V
G
S
F
V
P
A
E
E
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
------
G
K
S
T
F
M
V
E
M
E
E
V
A
L
I
L
K
E
A
T
E
N
S
L
V
L
L
D
E
V
G
R
G
T
S
S
L
D
G
V
A
I
A
T
A
V
A
E
A
L
H
E
R
-
R
A
Y
T
L
F
A
T
H
Y
F
E
L
T
A
L
--
G
L
P
R
L
K
N
L
H
V
A
A
R
E
E
A
G
G
L
V
F
Y
H
Q
V
L
P
G
P
A
S
K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
A
R
A
R
A
L
L
Q
A
M
-----------------------------------------------------------------------
2
PsiBlast_PDB
96.47
40%
-77
- C2 -
1OH6
4
MUTS_ECOLI
A:
[10-798]
---
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
28
PsiBlast_CBE
96.08
40%
-81
- C2 -
1WBD
2
MUTS_ECOLI
B:
[14-798]
-------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
Q
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
-----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
-------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
31
PsiBlast_CBE
95.89
40%
-82
- C2 -
1WB9
2
MUTS_ECOLI
B:
[14-798]
-------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
T
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
-----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
-------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
37
HHSearch
95.86
40%
-76
- C2 -
1WB9
4
MUTS_ECOLI
A:
[8-798]
-
D
A
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
T
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
-
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
D
-
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
-----------------
L
----------------
I
E
-
G
--
R
R
G
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
GTRDLVG
F
GVEN
A
P
R
G
-
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
-
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
---
T
A
G
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
-
N
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
6
PsiBlast_PDB
95.70
40%
-79
- C2 -
3ZLJ
2
MUTS_ECOLI
A:
[10-798]
---
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
------------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
---------
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
23
PsiBlast_CBE
95.05
40%
-81
- C2 -
1W7A
4
MUTS_ECOLI
B:
[14-798]
-------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
-----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
-------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
A
A
D
D
--
S
G
R
S
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
26
PsiBlast_CBE
94.97
40%
-83
- C2 -
1OH6
2
MUTS_ECOLI
B:
[14-798]
-------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
-----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
-------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
1
PsiBlast_PDB
94.78
40%
-79
- C2 -
1OH5
4
MUTS_ECOLI
A:
[10-798]
---
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
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I
L
A
R
L
A
L
R
T
A
R
P
R
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L
A
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M
R
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A
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Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
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K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
29
PsiBlast_CBE
94.44
40%
-80
- C2 -
3K0S
2
MUTS_ECOLI
B:
[17-797]
-----------
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
-----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
-----------
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
---------
S
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
N
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
13
PsiBlast_PDB
94.43
40%
-79
- C2 -
1FW6
8
MUTS_THEAQ
A:
[15-752]
-----
P
L
L
Q
Q
Y
V
E
L
R
D
Q
Y
P
D
Y
L
L
L
F
Q
V
G
D
F
Y
E
C
F
G
E
D
A
E
R
L
A
R
A
L
G
L
V
L
T
H
K
T
--
S
K
D
F
T
T
P
M
A
G
I
P
L
R
A
F
E
A
Y
A
E
R
L
L
K
M
G
F
R
L
A
V
A
D
Q
V
E
P
A
E
E
A
E
G
L
V
R
R
E
V
T
Q
L
L
T
P
G
T
L
L
Q
E
-
S
L
L
P
R
E
A
N
Y
L
A
A
I
A
T
G
D
G
--
W
G
L
A
F
L
D
V
S
T
G
E
F
K
G
T
V
L
K
-
S
K
S
A
L
Y
D
E
L
F
R
H
R
P
A
E
V
L
L
A
P
--
E
L
L
E
N
G
A
F
-----------------
L
---------------
D
E
F
R
K
R
F
P
V
M
L
S
---
E
A
P
F
E
P
E
G
-
E
G
------------------
P
L
A
L
-
R
R
A
R
G
A
L
L
A
Y
A
Q
R
T
Q
G
G
A
L
-
S
L
Q
P
F
R
F
Y
D
P
G
A
F
M
R
L
P
E
A
T
L
R
A
L
E
V
F
E
P
L
R
G
---
Q
D
T
L
F
S
V
L
D
E
T
R
T
A
P
G
R
R
L
L
Q
S
W
L
R
H
P
L
L
D
R
G
P
L
E
A
R
L
D
R
V
E
G
F
V
R
E
G
A
L
R
E
G
V
R
R
L
L
Y
R
L
A
D
L
E
R
L
A
T
R
L
E
L
G
R
A
S
P
K
D
L
G
A
L
R
R
S
L
Q
I
L
P
E
L
R
A
L
L
----
G
E
E
V
G
-----
L
P
D
L
S
P
L
K
E
E
L
E
A
A
L
V
E
D
P
P
L
K
V
S
E
G
G
L
I
R
E
G
Y
D
P
D
L
D
A
L
R
A
A
H
R
E
G
V
A
Y
F
L
E
L
E
E
R
E
R
E
R
T
G
I
P
T
L
K
V
G
Y
N
A
V
F
G
Y
Y
L
E
V
T
R
P
Y
Y
E
R
V
P
K
-
E
Y
R
P
V
Q
T
L
K
D
R
Q
R
Y
T
L
P
E
M
K
E
K
E
R
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
A
A
L
A
E
V
A
V
R
Y
G
Y
V
R
P
R
F
G
D
--
R
L
Q
I
R
A
G
R
H
P
V
V
E
R
---
R
T
E
F
V
P
N
D
--
L
E
M
A
H
E
L
V
L
I
T
G
P
N
M
A
G
K
S
T
F
L
R
Q
T
A
L
I
A
L
L
A
Q
V
G
S
F
V
P
A
E
E
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
------
G
K
S
T
F
M
V
E
M
E
E
V
A
L
I
L
K
E
A
T
E
N
S
L
V
L
L
D
E
V
G
R
G
T
S
S
L
D
G
V
A
I
A
T
A
V
A
E
A
L
H
E
R
-
R
A
Y
T
L
F
A
T
H
Y
F
E
L
T
A
L
--
G
L
P
R
L
K
N
L
H
V
A
A
R
E
E
A
G
G
L
V
F
Y
H
Q
V
L
P
G
P
A
S
K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
---------------------------------------------------------------------------------
4
PsiBlast_PDB
94.41
40%
-75
- C2 -
1OH8
4
MUTS_ECOLI
A:
[10-798]
---
H
T
P
M
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
-
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
14
PsiBlast_PDB
94.32
40%
-78
- C2 -
1EWQ
6
MUTS_THEAQ
A:
[15-752]
-----
P
L
L
Q
Q
Y
V
E
L
R
D
Q
Y
P
D
Y
L
L
L
F
Q
V
G
D
F
Y
E
C
F
G
E
D
A
E
R
L
A
R
A
L
G
L
V
L
T
H
K
T
--
S
K
D
F
T
T
P
M
A
G
I
P
L
R
A
F
E
A
Y
A
E
R
L
L
K
M
G
F
R
L
A
V
A
D
Q
V
E
P
A
E
E
A
E
G
L
V
R
R
E
V
T
Q
L
L
T
P
G
T
L
L
Q
E
-
S
L
L
P
R
E
A
N
Y
L
A
A
I
A
T
G
D
G
--
W
G
L
A
F
L
D
V
S
T
G
E
F
K
G
T
V
L
K
-
S
K
S
A
L
Y
D
E
L
F
R
H
R
P
A
E
V
L
L
A
P
--
E
L
L
E
N
G
A
F
-----------------
L
---------------
D
E
F
R
K
R
F
P
V
M
L
S
---
E
A
P
F
E
P
E
G
-
E
G
------------------
P
L
A
L
-
R
R
A
R
G
A
L
L
A
Y
A
Q
R
T
Q
G
G
A
L
-
S
L
Q
P
F
R
F
Y
D
P
G
A
F
M
R
L
P
E
A
T
L
R
A
L
E
V
F
E
P
L
R
G
---
Q
D
T
L
F
S
V
L
D
E
T
R
T
A
P
G
R
R
L
L
Q
S
W
L
R
H
P
L
L
D
R
G
P
L
E
A
R
L
D
R
V
E
G
F
V
R
E
G
A
L
R
E
G
V
R
R
L
L
Y
R
L
A
D
L
E
R
L
A
T
R
L
E
L
G
R
A
S
P
K
D
L
G
A
L
R
R
S
L
Q
I
L
P
E
L
R
A
L
L
----
G
E
E
V
G
-----
L
P
D
L
S
P
L
K
E
E
L
E
A
A
L
V
E
D
P
P
L
K
V
S
E
G
G
L
I
R
E
G
Y
D
P
D
L
D
A
L
R
A
A
H
R
E
G
V
A
Y
F
L
E
L
E
E
R
E
R
E
R
T
G
I
P
T
L
K
V
G
Y
N
A
V
F
G
Y
Y
L
E
V
T
R
P
Y
Y
E
R
V
P
K
-
E
Y
R
P
V
Q
T
L
K
D
R
Q
R
Y
T
L
P
E
M
K
E
K
E
R
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
A
A
L
A
E
V
A
V
R
Y
G
Y
V
R
P
R
F
G
D
--
R
L
Q
I
R
A
G
R
H
P
V
V
E
R
---
R
T
E
F
V
P
N
D
--
L
E
M
A
H
E
L
V
L
I
T
G
P
N
M
A
G
K
S
T
F
L
R
Q
T
A
L
I
A
L
L
A
Q
V
G
S
F
V
P
A
E
E
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
------
G
K
S
T
F
M
V
E
M
E
E
V
A
L
I
L
K
E
A
T
E
N
S
L
V
L
L
D
E
V
G
R
G
T
S
S
L
D
G
V
A
I
A
T
A
V
A
E
A
L
H
E
R
-
R
A
Y
T
L
F
A
T
H
Y
F
E
L
T
A
L
--
G
L
P
R
L
K
N
L
H
V
A
A
R
E
E
A
G
G
L
V
F
Y
H
Q
V
L
P
G
P
A
S
K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
---------------------------------------------------------------------------------
25
PsiBlast_CBE
94.24
40%
-81
- C2 -
1OH7
2
MUTS_ECOLI
B:
[14-798]
-------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
-----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
-------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
32
PsiBlast_CBE
93.67
40%
-79
* C2 *
1NNE
8
MUTS_THEAQ
B:
[15-762]
-----
P
L
L
Q
Q
Y
V
E
L
R
D
Q
Y
P
D
Y
L
L
L
F
Q
V
G
D
F
Y
E
C
F
G
E
D
A
E
R
L
A
R
A
L
G
L
V
L
T
H
K
T
--
S
K
D
F
T
T
P
M
A
G
I
P
L
R
A
F
E
A
Y
A
E
R
L
L
K
M
G
F
R
L
A
V
A
D
Q
V
E
P
------
L
V
R
R
E
V
T
Q
L
L
T
P
G
T
L
L
Q
E
-
S
L
L
P
R
E
A
N
Y
L
A
A
I
A
T
G
D
G
--
W
G
L
A
F
L
D
V
S
T
G
E
F
K
G
T
V
L
K
-
S
K
S
A
L
Y
D
E
L
F
R
H
R
P
A
E
V
L
L
A
P
--
E
L
L
E
N
G
A
F
-----------------
L
---------------
D
E
F
R
K
R
F
P
V
M
L
S
---
E
A
P
F
E
P
E
G
-
E
G
------------------
P
L
A
L
-
R
R
A
R
G
A
L
L
A
Y
A
Q
R
T
Q
G
G
A
L
-
S
L
Q
P
F
R
F
Y
D
P
G
A
F
M
R
L
P
E
A
T
L
R
A
L
E
V
F
E
P
L
R
G
---
Q
D
T
L
F
S
V
L
D
E
T
R
T
A
P
G
R
R
L
L
Q
S
W
L
R
H
P
L
L
D
R
G
P
L
E
A
R
L
D
R
V
E
G
F
V
R
E
G
A
L
R
E
G
V
R
R
L
L
Y
R
L
A
D
L
E
R
L
A
T
R
L
E
L
G
R
A
S
P
K
D
L
G
A
L
R
R
S
L
Q
I
L
P
E
L
R
A
L
L
----
G
E
E
V
G
-----
L
P
D
L
S
P
L
K
E
E
L
E
A
A
L
V
E
D
P
P
L
K
V
S
E
G
G
L
I
R
E
G
Y
D
P
D
L
D
A
L
R
A
A
H
R
E
G
V
A
Y
F
L
E
L
E
E
R
E
R
E
R
T
G
I
P
T
L
K
V
G
Y
N
A
V
F
G
Y
Y
L
E
V
T
R
P
Y
Y
E
R
V
P
K
-
E
Y
R
P
V
Q
T
L
K
D
R
Q
R
Y
T
L
P
E
M
K
E
K
E
R
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
A
A
L
A
E
V
A
V
R
Y
G
Y
V
R
P
R
F
G
D
--
R
L
Q
I
R
A
G
R
H
P
V
V
E
R
---
R
T
E
F
V
P
N
D
L
E
M
--
A
H
E
L
V
L
I
T
G
P
N
M
A
G
K
S
T
F
L
R
Q
T
A
L
I
A
L
L
A
Q
V
G
S
F
V
P
A
E
E
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
S
D
D
L
A
G
G
K
S
T
F
M
V
E
M
E
E
V
A
L
I
L
K
E
A
T
E
N
S
L
V
L
L
D
E
V
G
R
G
T
S
S
L
D
G
V
A
I
A
T
A
V
A
E
A
L
H
E
R
-
R
A
Y
T
L
F
A
T
H
Y
F
E
L
T
A
L
--
G
L
P
R
L
K
N
L
H
V
A
A
R
E
E
A
G
G
L
V
F
Y
H
Q
V
L
P
G
P
A
S
K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
A
R
A
R
A
L
L
Q
A
M
-----------------------------------------------------------------------
27
PsiBlast_CBE
93.58
40%
-82
- C2 -
1OH5
2
MUTS_ECOLI
B:
[14-798]
-------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
-----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
-------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
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L
A
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M
R
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A
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Q
Q
L
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E
L
R
A
Q
L
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V
D
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A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
24
PsiBlast_CBE
93.56
40%
-81
- C2 -
1OH8
2
MUTS_ECOLI
B:
[14-798]
-------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
-----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
-------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
40
HHSearch
93.51
41%
-75
- C2 -
1EWQ
6
MUTS_THEAQ
A:
[11-764]
-
G
P
L
P
P
L
L
Q
Q
Y
V
E
L
R
D
Q
Y
P
D
Y
L
L
L
F
Q
V
G
D
F
Y
E
C
F
G
E
D
A
E
R
L
A
R
A
L
G
L
V
L
T
H
K
T
S
K
-
D
F
-
T
T
P
M
A
G
I
P
L
R
A
F
E
A
Y
A
E
R
L
L
K
M
G
F
R
L
A
V
A
D
Q
V
E
P
A
E
E
A
E
G
L
V
R
R
E
V
T
Q
L
L
T
P
G
T
L
L
Q
E
S
L
L
-
P
R
E
A
N
Y
L
A
A
I
A
T
G
--
D
G
W
G
L
A
F
L
D
V
S
T
G
E
F
K
G
T
V
L
K
S
-
K
S
A
L
Y
D
E
L
F
R
H
R
P
A
E
V
L
L
A
P
--
E
--
L
L
E
N
G
-----------------
A
---------------
F
L
D
E
F
R
K
R
F
P
-
V
M
L
S
E
A
P
F
E
P
E
G
------
E
--------------
G
P
L
A
L
R
R
A
R
G
A
L
L
A
Y
A
Q
R
T
Q
G
G
A
-
L
S
L
Q
P
F
R
F
Y
D
P
G
A
F
M
R
L
P
E
A
T
L
R
A
L
E
V
F
E
P
L
R
---
G
Q
D
T
L
F
S
V
L
D
E
T
R
T
A
P
G
R
R
L
L
Q
S
W
L
R
H
P
L
L
D
R
G
P
L
E
A
R
L
D
R
V
E
G
F
V
R
E
G
A
L
R
E
G
V
R
R
L
L
Y
R
L
A
D
L
E
R
L
A
T
R
L
E
L
G
R
A
S
P
K
D
L
G
A
L
R
R
S
L
Q
I
L
P
E
L
R
A
L
L
G
E
E
V
---------
G
L
P
D
L
S
P
L
K
E
E
L
E
A
A
L
V
E
D
P
P
L
K
V
S
E
G
G
L
I
R
E
G
Y
D
P
D
L
D
A
L
R
A
A
H
R
E
G
V
A
Y
F
L
E
L
E
E
R
E
R
E
R
T
G
I
P
T
L
K
V
G
Y
N
A
V
F
G
Y
Y
L
E
V
T
R
P
Y
Y
E
R
V
P
K
E
-
Y
R
P
V
Q
T
L
K
D
R
Q
R
Y
T
L
P
E
M
K
E
K
E
R
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
A
A
L
A
E
V
A
V
R
Y
G
Y
V
R
P
R
F
G
D
--
R
L
Q
I
R
A
G
R
H
P
V
V
E
R
R
---
T
E
F
V
P
N
D
L
E
M
A
--
H
E
L
V
L
I
T
G
P
N
M
A
G
K
S
T
F
L
R
Q
T
A
L
I
A
L
L
A
Q
V
G
S
F
V
P
A
E
E
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
------
G
K
S
T
F
M
V
E
M
E
E
V
A
L
I
L
K
E
A
T
E
N
S
L
V
L
L
D
E
V
G
R
G
T
S
S
L
D
G
V
A
I
A
T
A
V
A
E
A
L
H
E
-
R
R
A
Y
T
L
F
A
T
H
Y
F
E
L
T
A
L
G
--
L
P
R
L
K
N
L
H
V
A
A
R
E
E
A
G
G
L
V
F
Y
H
Q
V
L
P
G
P
A
S
K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
A
R
A
R
A
L
L
Q
A
M
A
A
---------------------------------------------------------------------
30
PsiBlast_CBE
93.40
40%
-82
- C2 -
1WBB
2
MUTS_ECOLI
B:
[14-798]
-------
M
Q
Q
Y
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
A
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
-----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
-------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
-
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
-
D
F
T
A
G
L
Q
P
V
--
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
N
-
E
P
F
I
A
N
P
L
N
L
S
P
Q
R
R
M
L
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
21
PsiBlast_CBE
91.43
40%
-77
- C2 -
3ZLJ
2
MUTS_ECOLI
B:
[26-798]
-------------------
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
---------------------
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
------------
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
-
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
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I
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E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
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I
T
Q
N
L
A
G
-
G
A
E
N
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L
A
S
V
L
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V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
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T
R
V
L
L
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R
Q
Q
T
I
G
A
L
Q
-
D
F
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A
G
L
Q
P
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R
Q
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L
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H
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Y
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I
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R
G
Q
S
H
L
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N
-
Y
M
R
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Q
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K
N
A
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R
Y
I
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P
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L
K
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Y
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L
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K
G
K
A
L
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L
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Q
L
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L
L
L
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L
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L
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V
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N
-
E
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T
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L
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L
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M
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V
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N
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L
D
A
L
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H
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D
T
I
A
F
M
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Q
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A
A
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K
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L
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A
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V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
---------------------------------------------------------------------
22
PsiBlast_CBE
89.59
40%
-77
- C2 -
2WTU
4
MUTS_ECOLI
B:
[36-798]
-----------------------------
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
-------------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
---------------
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
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W
-
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
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R
F
R
L
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E
-
P
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D
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M
A
A
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Q
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T
N
P
A
E
L
L
Y
A
E
--
D
--
F
A
E
M
S
LIEGRRG
L
R
R
R
P
LWEFE
I
---------------
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
----
A
P
R
G
--------
L
----
C
------
A
A
G
C
L
L
Q
Y
A
K
D
T
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R
T
T
L
P
H
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S
---------------------------------------------------------------------