@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1420: (2016-03-24 )
MNNLQTKFPHIAIKLNEPLSKYTYTKTGGAADVFVMPKTIEEAQEVVAYCHQNKIPLTILGNGSNLIIKDGGIRGVILHLDLLQTIERNNTQIVAMSGAKLIDTAKFALNESLSGLEFACGIPGSIGGALHMNAGAYGGEISDVLEAATVLTQTGELKKLKRSELKAAYRFSTIAEKNYIVLDATFSLALEEKNLIQAKMDELTAAREAKQPLEYPSCGSVFKRPPGHFAGKLIQDSGLQGHIIGGAQVSLKHAGFIVNIGGATATDYMNLIAYVQQTVREKFDVELETEVKIIGEDK
Atome Classification :
(20 SA)
----.........10........20........30........40..--......50........60.......-.---70........80---..-......----.90---.........100........110.......120.......130.......140....-...150.-.-......160.......170-......---...---180.......-----------------190--------------.-------------.--...----..200..-------------..-----------...210..--.--......220...-----------------------..--------------------------.---------.---230.......240.......250.......260.......270.......280.......290......----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MNNLQTKF
P
H
I
A
I
K
LNEPLSK
Y
T
YTKTGGA
A
D
V
F
VMP
K
T
I
E
E
A
--
Q
E
V
V
A
Y
C
H
QNKI
P
L
T
I
LGNG
S
N
L
I
I
-K---DGG
I
R
G
V
I
L
H
L
----
D
L
-
L
Q
T
I
ER----NN----
T
Q
I
V
A
MSG
A
K
-
L
I
D
T
A
K
F
A
L
NESLSGL
E
F
ACGIPGSIGG
A
L
H
MNAGAYG
G
E
I
S
D
V
L
E
-
A
A
T
V
L
-T-Q-T
G
E
L
K
K
L
K
R
S
E
L
K
A
A
Y
R
---
F
STIAE---K
N
Y
---
I
V
L
DA
T
F
S
L
A
-----------------LEE--------------
K
-------------
N
--
L
I
Q
----
A
K
M
D
E
L
T
-------------
A
A
-----------
R
E
AK--QP--L--EYPSC
G
S
V
FKRP-----------------------P
G
--------------------------
H
---------
F
---
A
G
K
L
I
QDSGL
Q
G
H
I
IG
G
A
Q
V
S
L
K
HA
G
F
I
V
NIGGA
T
A
T
D
Y
M
N
L
I
A
Y
V
Q
Q
T
V
R
E
KFD
V
E
L
E
T
E
V
K
I
IGEDK----
33
HHSearch
97.80
100%
-115
- C2 -
3TX1
5
MURB_LISMO
A:
[25-322]
----
M
N
N
L
Q
T
K
F
P
H
I
A
I
K
L
N
E
P
L
S
K
Y
T
Y
T
K
T
G
G
A
A
D
V
F
V
M
P
K
T
I
E
E
A
--
Q
E
V
V
A
Y
C
H
Q
N
K
I
P
L
T
I
L
G
N
G
S
N
L
I
I
-
K
---
D
G
G
I
R
G
V
I
L
H
L
----
D
L
-
L
Q
T
I
E
R
----
N
N
----
T
Q
I
V
A
M
S
G
A
K
-
L
I
D
T
A
K
F
A
L
N
E
S
L
S
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
L
H
M
N
A
G
A
Y
G
G
E
I
S
D
V
L
E
-
A
A
T
V
L
-
T
-
Q
-
T
G
E
L
K
K
L
K
R
S
E
L
K
--
Y
R
----
S
T
I
A
E
---
K
N
Y
---
I
V
L
D
A
T
F
S
L
A
-----------------
L
E
E
--------------
K
-------------
N
--
L
I
Q
----
A
K
M
D
E
L
T
-------------
A
A
-----------
R
E
A
K
--
Q
P
--
L
--
E
Y
P
S
C
G
S
V
F
K
R
P
-----------------------
P
G
--------------------------
H
---------
F
---
A
G
K
L
I
Q
D
S
G
L
Q
G
H
I
I
G
G
A
Q
V
S
L
K
H
A
G
F
I
V
N
I
G
G
A
T
A
T
D
Y
M
N
L
I
A
Y
V
Q
Q
T
V
R
E
K
F
D
V
E
L
E
T
E
V
K
I
I
G
E
D
K
----
1
PsiBlast_PDB
97.80
100%
-115
- C2 -
3TX1
5
MURB_LISMO
A:
[25-322]
----
M
N
N
L
Q
T
K
F
P
H
I
A
I
K
L
N
E
P
L
S
K
Y
T
Y
T
K
T
G
G
A
A
D
V
F
V
M
P
K
T
I
E
E
A
--
Q
E
V
V
A
Y
C
H
Q
N
K
I
P
L
T
I
L
G
N
G
S
N
L
I
I
-
K
---
D
G
G
I
R
G
V
I
L
H
L
----
D
L
-
L
Q
T
I
E
R
----
N
N
----
T
Q
I
V
A
M
S
G
A
K
-
L
I
D
T
A
K
F
A
L
N
E
S
L
S
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
L
H
M
N
A
G
A
Y
G
G
E
I
S
D
V
L
E
-
A
A
T
V
L
-
T
-
Q
-
T
G
E
L
K
K
L
K
R
S
E
L
K
--
Y
R
----
S
T
I
A
E
---
K
N
Y
---
I
V
L
D
A
T
F
S
L
A
-----------------
L
E
E
--------------
K
-------------
N
--
L
I
Q
----
A
K
M
D
E
L
T
-------------
A
A
-----------
R
E
A
K
--
Q
P
--
L
--
E
Y
P
S
C
G
S
V
F
K
R
P
-----------------------
P
G
--------------------------
H
---------
F
---
A
G
K
L
I
Q
D
S
G
L
Q
G
H
I
I
G
G
A
Q
V
S
L
K
H
A
G
F
I
V
N
I
G
G
A
T
A
T
D
Y
M
N
L
I
A
Y
V
Q
Q
T
V
R
E
K
F
D
V
E
L
E
T
E
V
K
I
I
G
E
D
K
----
50
Fugue
89.35
58%
-108
- C2 -
1HSK
1
MURB_STAAU
A:
[15-317]
N
K
D
I
Y
Q
A
L
Q
Q
L
I
P
N
E
K
I
K
V
D
E
P
L
K
R
Y
T
Y
T
K
T
G
G
N
A
D
F
Y
I
T
P
T
K
N
E
E
V
--
Q
A
V
V
K
Y
A
Y
Q
N
E
I
P
V
T
Y
L
G
N
G
S
N
I
I
I
-
R
---
E
G
G
I
R
G
I
V
I
S
L
----
L
S
-
L
D
H
I
E
V
----
S
D
----
D
A
I
I
A
G
S
G
A
A
-
I
I
D
V
S
R
V
A
R
D
Y
A
L
T
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
V
Y
M
N
A
G
A
Y
G
G
E
V
K
D
C
I
D
-
Y
A
L
C
V
-
N
-
E
-
Q
G
S
L
I
K
L
T
T
K
E
L
E
L
D
Y
R
---
N
S
I
I
Q
K
---
E
H
L
---
V
V
L
E
A
A
F
T
L
A
-----------------
P
G
K
--------------
M
-------------
T
--
E
I
Q
----
A
K
M
D
D
L
T
-------------
E
R
-----------
R
E
S
K
--
Q
P
--
L
--
E
Y
P
S
C
G
S
V
F
Q
R
P
-----------------------
P
G
--------------------------
H
---------
F
---
A
G
K
L
I
Q
D
S
N
L
Q
G
H
R
I
G
G
V
E
V
S
T
K
H
A
G
F
M
V
N
V
D
N
G
T
A
T
D
Y
E
N
L
I
H
Y
V
Q
K
T
V
K
E
K
F
G
I
E
L
N
R
E
V
R
I
I
G
E
H
P
K---
2
PsiBlast_PDB
89.23
59%
-112
- C2 -
1HSK
1
MURB_STAAU
A:
[22-314]
-------
L
Q
Q
L
I
P
N
E
K
I
K
V
D
E
P
L
K
R
Y
T
Y
T
K
T
G
G
N
A
D
F
Y
I
T
P
T
K
N
E
E
V
--
Q
A
V
V
K
Y
A
Y
Q
N
E
I
P
V
T
Y
L
G
N
G
S
N
I
I
I
-
R
---
E
G
G
I
R
G
I
V
I
S
L
----
L
S
-
L
D
H
I
E
V
----
S
D
----
D
A
I
I
A
G
S
G
A
A
-
I
I
D
V
S
R
V
A
R
D
Y
A
L
T
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
V
Y
M
N
A
G
A
Y
G
G
E
V
K
D
C
I
D
-
Y
A
L
C
V
-
N
-
E
-
Q
G
S
L
I
K
L
T
T
K
E
L
E
L
D
Y
R
---
N
S
I
I
Q
K
---
E
H
L
---
V
V
L
E
A
A
F
T
L
A
-----------------
P
G
K
--------------
M
-------------
T
--
E
I
Q
----
A
K
M
D
D
L
T
-------------
E
R
-----------
R
E
S
K
--
Q
P
--
L
--
E
Y
P
S
C
G
S
V
F
Q
R
P
-----------------------
P
G
--------------------------
H
---------
F
---
A
G
K
L
I
Q
D
S
N
L
Q
G
H
R
I
G
G
V
E
V
S
T
K
H
A
G
F
M
V
N
V
D
N
G
T
A
T
D
Y
E
N
L
I
H
Y
V
Q
K
T
V
K
E
K
F
G
I
E
L
N
R
E
V
R
I
I
G
E
------
34
HHSearch
89.01
59%
-109
- C2 -
1HSK
1
MURB_STAAU
A:
[21-315]
------
A
L
Q
Q
L
I
P
N
E
K
I
K
V
D
E
P
L
K
R
Y
T
Y
T
K
T
G
G
N
A
D
F
Y
I
T
P
T
K
N
E
E
V
--
Q
A
V
V
K
Y
A
Y
Q
N
E
I
P
V
T
Y
L
G
N
G
S
N
I
I
I
-
R
---
E
G
G
I
R
G
I
V
I
S
L
----
L
S
-
L
D
H
I
E
V
----
S
D
----
D
A
I
I
A
G
S
G
A
A
-
I
I
D
V
S
R
V
A
R
D
Y
A
L
T
G
L
E
F
A
C
G
I
P
G
S
I
G
G
A
V
Y
M
N
A
G
A
Y
G
G
E
V
K
D
C
I
D
-
Y
A
L
C
V
-
N
-
E
-
Q
G
S
L
I
K
L
T
T
K
E
L
E
L
D
Y
R
---
N
S
I
I
Q
K
---
E
H
L
---
V
V
L
E
A
A
F
T
L
A
-----------------
P
G
K
--------------
M
-------------
T
--
E
I
Q
----
A
K
M
D
D
L
T
-------------
E
R
-----------
R
E
S
K
--
Q
P
--
L
--
E
Y
P
S
C
G
S
V
F
Q
R
P
-----------------------
P
G
--------------------------
H
---------
F
---
A
G
K
L
I
Q
D
S
N
L
Q
G
H
R
I
G
G
V
E
V
S
T
K
H
A
G
F
M
V
N
V
D
N
G
T
A
T
D
Y
E
N
L
I
H
Y
V
Q
K
T
V
K
E
K
F
G
I
E
L
N
R
E
V
R
I
I
G
E
H
-----
3
PsiBlast_PDB
80.44
41%
-101
- C2 -
4PYT
4
MURB_BACLD
A:
[19-302]
-------------------
N
E
P
L
A
N
H
T
T
I
K
I
G
G
P
A
D
C
L
V
I
P
K
D
I
Q
A
V
--
R
D
T
M
E
V
V
K
N
H
G
V
Q
W
R
A
I
G
R
G
S
N
L
L
V
-
L
---
D
E
G
I
R
G
V
V
I
K
L
----
G
A
G
L
D
H
M
E
I
----
D
G
----
E
Q
V
T
V
G
G
G
Y
S
-
V
V
R
L
S
T
G
I
S
K
K
G
L
S
G
L
E
F
A
S
G
I
P
G
S
V
G
G
A
V
Y
M
N
A
G
A
H
G
S
D
I
S
R
I
L
V
-
K
A
L
I
L
-
F
-
E
-
D
G
T
M
E
W
L
T
N
E
E
M
E
F
S
Y
R
---
T
S
I
L
Q
N
---
K
R
P
G
--
I
C
L
E
A
V
L
Q
L
E
-----------------
Q
K
E
--------------
R
-------------
D
--
A
I
V
----
A
Q
M
Q
K
N
K
-------------
D
Y
-----------
R
K
E
T
--
Q
P
--
V
--
S
N
P
C
A
G
S
I
F
R
N
P
-----------------------
L
P
--------------------------
D
---------
H
---
A
G
R
L
V
E
Q
A
G
L
K
G
H
R
I
G
G
A
K
V
S
E
M
H
G
N
F
I
V
N
A
G
G
A
T
A
K
D
V
L
D
L
I
A
F
I
Q
K
T
I
K
E
K
Y
D
I
D
M
H
T
E
V
E
I
V
G
E
K
-----
6
PsiBlast_PDB
73.54
28%
-86
- C2 -
3I99
3
MURB_VIBCH
A:
[13-345]
----------------
I
Q
L
G
A
N
L
K
P
Y
H
T
F
G
I
E
Q
L
A
A
Q
L
V
V
A
E
S
I
D
D
L
--
K
A
L
Y
C
S
A
E
W
A
S
L
P
K
L
I
I
G
K
G
S
N
M
L
F
-
T
CHY
T
G
M
I
--
V
V
N
R
L
----
N
G
-
I
E
H
Q
Q
D
----
D
D
----
Y
H
R
L
H
V
A
G
G
E
D
W
P
S
L
V
S
W
C
V
E
Q
G
I
G
G
L
E
N
L
A
L
I
P
G
C
A
G
S
A
P
I
Q
N
I
G
A
Y
G
V
E
F
K
D
V
C
D
-
Y
V
E
Y
L
-
C
L
E
-
T
G
T
V
K
R
L
T
M
E
E
C
Q
F
G
Y
R
---
D
S
I
F
K
H
---
Q
L
Y
QKA
V
V
T
A
V
G
L
K
F
A
-----------------
K
A
W
--------------
Q
-------------
P
--
I
I
Q
Y---
G
P
L
K
D
L
S
SDCA
I
H
D
V
Y
Q
R
V
C
A
T
-----------
R
M
E
K
LP
D
P
--
A
--
V
M
G
N
A
G
S
F
F
K
N
P
V
I
S
Q
Q
A
F
A
R
L
Q
I
E
H
PD
V
V
A
Y
---
P
A
--------------------------
E
Q
G
V
K
V
----
A
---
A
G
W
L
I
D
Q
A
G
L
K
G
H
Q
I
G
G
A
K
V
H
P
K
Q
A
L
V
I
V
N
T
G
D
A
S
A
Q
D
V
L
M
L
A
A
D
I
Q
Q
R
V
F
N
C
Y
G
I
E
L
E
H
E
V
R
F
I
G
E
S
E
----
30
HHSearch
73.25
32%
-89
- C2 -
3I99
3
MURB_VIBCH
A:
[9-344]
------------
T
T
M
Q
I
Q
L
G
A
N
L
K
P
Y
H
T
F
G
I
E
Q
L
A
A
Q
L
V
V
A
E
S
I
D
D
L
--
K
A
L
Y
C
S
A
E
W
A
S
L
P
K
L
I
I
G
K
G
S
N
M
L
F
-
T
---
C
-
H
Y
T
G
M
I
V
V
N
----
R
--
L
N
G
I
E
H
Q
Q
D
D
D
Y
----
H
R
L
H
V
A
G
G
E
D
-
W
P
S
L
V
S
W
C
V
E
Q
G
I
G
G
L
E
N
L
A
L
I
P
G
C
A
G
S
A
P
I
Q
N
I
G
A
Y
G
V
E
F
K
D
V
C
D
-
Y
V
E
Y
L
-
C
-
L
E
T
G
T
V
K
R
L
T
M
E
E
C
Q
F
G
Y
R
---
D
S
I
F
K
H
QLY
Q
K
A
---
V
V
T
A
V
G
L
K
F
A
-----------------
K
A
W
QPIIQYGPLKDLSS
D
-------------
C
--
A
I
H
----
D
V
Y
Q
R
V
C
-------------
A
T
-----------
R
M
E
K
--
L
P
--
D
PA
V
M
G
N
A
G
S
F
F
K
N
P
-----------------------
V
I
S
Q
Q
A
F
A
R
L
Q
I
E
H
PD
V
V
A
Y
P
A
EQ
G
V
K
-
V
---------
A
---
A
G
W
L
I
D
Q
A
G
L
K
G
H
Q
I
G
G
A
K
V
H
P
K
Q
A
L
V
I
V
N
T
G
D
A
S
A
Q
D
V
L
M
L
A
A
D
I
Q
Q
R
V
F
N
C
Y
G
I
E
L
E
H
E
V
R
F
I
G
E
S
-----
31
HHSearch
72.18
28%
-88
- C2 -
1UXY
2
MURB_ECOLI
A:
[1-331]
--------------------
H
S
L
K
P
W
N
T
F
G
I
D
H
N
A
Q
H
I
V
C
A
E
D
E
Q
Q
L
--
L
N
A
W
Q
Y
A
T
A
E
G
Q
P
V
L
I
L
G
E
G
S
N
V
L
F
-
L
---
E
D
-
Y
R
G
T
V
I
I
N
----
R
--
I
K
G
I
E
I
H
D
E
P
D
A
----
W
Y
L
H
V
G
A
G
E
N
-
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
-
Y
V
D
S
V
-
E
-
L
A
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
---
D
S
I
F
K
H
EYQ
D
R
F
---
A
I
V
A
V
G
L
R
L
P
-----------------
K
E
W
--------------
Q
PVLTYGDLTRLDP
T
TV
T
P
Q
----
Q
V
F
N
A
V
C
-------------
H
M
-----------
R
T
T
K
--
L
P
--
D
PK
V
N
G
N
A
G
A
F
F
K
N
P
-----------------------
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
PTA
P
N
Y
P
Q
ADG
S
V
K
L
---------
A
---
A
G
W
L
I
D
Q
C
Q
L
K
G
M
Q
I
G
G
A
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
A
S
G
----
7
PsiBlast_PDB
70.64
25%
-89
- C2 -
4JAY
5
MURB_PSEAE
A:
[3-336]
---------------
S
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
A
L
A
R
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
---
D
--
V
E
A
L
V
L
R
M
A
S
Q
G
R
R
-
I
V
S
D
A
A
----
D
S
----
V
L
V
E
A
E
A
G
E
A
-
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
D
-
S
L
T
A
L
D
R
-
Q
-
D
G
T
L
R
E
F
D
R
Q
A
C
R
F
G
Y
R
---
D
S
L
F
K
Q
---
E
P
D
---
R
W
L
I
L
R
V
R
L
R
L
T
RRERLHLDY
G
P
V
R
Q
R
L
E
E
--------------
E
-------------
G
--
I
A
S
----
P
T
A
R
D
V
S
R
V
I
C
---------
A
I
-----------
R
R
E
K
LP
D
P
--
A
--
V
L
G
N
A
G
S
F
F
K
N
P
L
V
D
A
T
Q
A
E
R
L
R
Q
A
F
PD
L
V
G
Y
P
Q
A
D
G
--------------------------
R
---------
L
K
L
A
A
G
W
L
I
D
K
G
G
W
K
G
F
R
D
G
P
V
G
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
------------
8
PsiBlast_PDB
70.42
25%
-88
- C2 -
4JB1
8
MURB_PSEAE
A:
[4-336]
----------------
L
E
L
Q
E
H
C
S
L
K
P
Y
N
T
F
G
I
D
V
R
A
R
L
L
A
H
A
R
D
E
A
D
V
R
E
A
L
A
L
A
R
E
R
G
L
P
L
L
V
I
G
G
G
S
N
L
L
L
T
R
---
D
--
V
E
A
L
V
L
R
M
A
S
Q
G
R
R
-
I
V
S
D
A
A
----
D
S
----
V
L
V
E
A
E
A
G
E
A
-
W
D
P
F
V
Q
W
S
L
E
R
G
L
A
G
L
E
N
L
S
L
I
P
G
T
V
G
A
A
P
M
Q
N
I
G
A
Y
G
V
E
L
K
D
V
F
D
-
S
L
T
A
L
D
R
-
Q
-
D
G
T
L
R
E
F
D
R
Q
A
C
R
F
G
Y
R
---
D
S
L
F
K
Q
---
E
P
D
---
R
W
L
I
L
R
V
R
L
R
L
T
R
R
E
R
L
H
LDY
G
P
V
R
Q
R
L
E
E
--------------
E
-------------
G
--
I
A
S
----
P
T
A
R
D
V
S
R
V
I
C
---------
A
I
-----------
R
R
E
K
LP
D
P
--
A
--
V
L
G
N
A
G
S
F
F
K
N
P
L
V
D
A
T
Q
A
E
R
L
R
Q
A
F
PD
L
V
G
Y
P
Q
A
D
G
--------------------------
R
---------
L
KLA
A
G
W
L
I
D
K
G
G
W
K
G
F
R
D
G
P
V
G
V
H
A
Q
Q
A
L
V
L
V
N
H
G
G
A
T
G
A
Q
V
R
A
L
A
E
R
I
Q
E
D
V
R
R
R
F
G
V
E
L
E
P
E
------------
9
PsiBlast_PDB
69.80
27%
-89
- C2 -
2Q85
2
MURB_ECOLI
A:
[42-330]
-------------------------------------------------------------
P
V
L
I
L
G
E
G
S
N
V
L
F
-
L
---
E
D
-
Y
R
G
T
V
I
-
I
----
N
R
-
I
K
G
I
E
I
----
H
D
E
PD
A
W
Y
L
H
V
G
A
G
E
N
-
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
-
L
-
A
-
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
DSI
F
K
H
E
Y
Q
---
D
R
F
---
A
I
V
A
V
G
L
R
L
P
-----------------
K
E
W
--------------
Q
-------------
P
--
V
L
T
YGDL
T
R
L
D
P
T
T
-------------
V
T
P
Q
Q
V
F
N
A
V
C
H
M
R
T
T
K
LP
D
P
--
K
--
V
N
G
N
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
PTA------
P
N
--------------------------
Y
P
Q
ADG
S
V
K
L
A
---
A
G
W
L
I
D
Q
C
Q
L
K
G
M
Q
I
G
G
A
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
-------
12
PsiBlast_PDB
69.67
27%
-88
- C2 -
2MBR
2
MURB_ECOLI
A:
[40-328]
-------------------------------------------------------------
P
V
L
I
L
G
E
G
S
N
V
L
F
-
L
---
E
D
-
Y
R
G
T
V
I
-
I
----
N
R
-
I
K
G
I
E
I
----
H
D
E
PD
A
W
Y
L
H
V
G
A
G
E
N
-
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
-
L
-
A
-
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
DSI
F
K
H
E
Y
Q
---
D
R
F
---
A
I
V
A
V
G
L
R
L
P
-----------------
K
E
W
--------------
Q
-------------
P
--
V
L
T
YGDL
T
R
L
D
P
T
T
-------------
V
T
P
Q
Q
V
F
N
A
V
C
H
M
R
T
T
K
LP
D
P
--
K
--
V
N
G
N
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
PTA------
P
N
--------------------------
Y
P
Q
ADG
S
V
K
L
A
---
A
G
W
L
I
D
Q
C
Q
L
K
G
M
Q
I
G
G
A
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
-------
11
PsiBlast_PDB
69.54
27%
-91
- C2 -
1MBT
2
MURB_ECOLI
A:
[42-330]
-------------------------------------------------------------
P
V
L
I
L
G
E
G
S
N
V
L
F
-
L
---
E
D
-
Y
R
G
T
V
I
-
I
----
N
R
-
I
K
G
I
E
I
----
H
D
E
PD
A
W
Y
L
H
V
G
A
G
E
N
-
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
-
L
-
A
-
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
DSI
F
K
H
E
Y
Q
---
D
R
F
---
A
I
V
A
V
G
L
R
L
P
-----------------
K
E
W
--------------
Q
-------------
P
--
V
L
T
YGDL
T
R
L
D
P
T
T
-------------
V
T
P
Q
Q
V
F
N
A
V
C
H
M
R
T
T
K
LP
D
P
--
K
--
V
N
G
N
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
FPTA------
P
N
--------------------------
Y
P
Q
ADG
S
V
K
L
A
---
A
G
W
L
I
D
Q
C
Q
L
K
G
M
Q
I
G
G
A
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
-------
13
PsiBlast_PDB
69.48
26%
-87
- C2 -
1UXY
2
MURB_ECOLI
A:
[40-328]
-------------------------------------------------------------
P
V
L
I
L
G
E
G
S
N
V
L
F
-
L
---
E
D
-
Y
R
G
T
V
I
-
I
----
N
R
-
I
K
G
I
E
I
----
H
D
E
PD
A
W
Y
L
H
V
G
A
G
E
N
-
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
-
L
-
A
-
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
DSI
F
K
H
E
Y
Q
---
D
R
F
---
A
I
V
A
V
G
L
R
L
P
-----------------
K
E
W
--------------
Q
-------------
P
--
V
L
T
YGDL
T
R
L
D
P
T
T
-------------
V
T
P
Q
Q
V
F
N
A
V
C
H
M
R
T
T
K
LP
D
P
--
K
--
V
N
G
N
A
G
A
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
Q
F
PTA------
P
N
--------------------------
Y
P
Q
ADG
S
V
K
L
A
---
A
G
W
L
I
D
Q
C
Q
L
K
G
M
Q
I
G
G
A
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
-------
10
PsiBlast_PDB
69.44
27%
-85
- C2 -
1MBB
2
MURB_ECOLI
A:
[42-330]
-------------------------------------------------------------
P
V
L
I
L
G
E
G
S
N
V
L
F
-
L
---
E
D
-
Y
R
G
T
V
I
-
I
----
N
R
-
I
K
G
I
E
I
----
H
D
E
PD
A
W
Y
L
H
V
G
A
G
E
N
-
W
H
R
L
V
K
Y
T
L
Q
E
G
M
P
G
L
E
N
L
A
L
I
P
G
C
V
G
S
S
P
I
Q
N
I
G
A
Y
G
V
E
L
Q
R
V
C
A
Y
V
D
S
V
E
-
L
-
A
-
T
G
K
Q
V
R
L
T
A
K
E
C
R
F
G
Y
R
DSI
F
K
H
E
Y
Q
---
D
R
F
---
A
I
V
A
V
G
L
R
L
P
-----------------
K
E
W
--------------
Q
-------------
P
--
V
L
T
YGDL
T
R
L
D
P
T
T
-------------
V
T
P
Q
Q
V
F
N
A
V
C
H
M
R
T
T
K
LP
D
P
--
K
--
V
N
G
N
A
G
S
F
F
K
N
P
V
V
S
A
E
T
A
K
A
L
L
S
QFPT
A
------
P
N
--------------------------
Y
P
Q
ADG
S
V
K
L
A
---
A
G
W
L
I
D
Q
C
Q
L
K
G
M
Q
I
G
G
A
A
V
H
R
Q
Q
A
L
V
L
I
N
E
D
N
A
K
S
E
D
V
V
Q
L
A
H
H
V
R
Q
K
V
G
E
K
F
N
V
W
L
E
P
E
V
R
F
I
G
-------
32
HHSearch
69.10
37%
-76
- C2 -
2GQT
2
MURB_THET8
A:
[2-267]
-------------
E
F
M
R
V
E
R
V
L
L
K
D
Y
T
T
L
G
V
G
G
P
A
E
L
W
-
T
V
E
T
R
E
E
L
--
K
R
A
------
T
E
A
P
Y
R
V
L
G
N
G
S
N
L
L
V
-
L
---
D
E
G
V
P
E
R
V
I
R
L
----
A
G
E
F
Q
T
Y
-------
D
----
L
K
G
W
V
G
A
G
T
L
-
L
P
L
L
V
Q
E
A
A
R
A
G
L
S
G
L
E
G
L
L
G
I
P
A
Q
V
G
G
A
V
K
M
N
A
G
T
R
F
G
E
M
A
D
A
L
E
-
A
V
E
V
F
-
H
---
D
G
A
F
H
V
Y
C
P
E
E
L
G
F
G
Y
R
---
K
S
H
L
P
P
----
G
G
---
I
V
T
R
V
R
L
K
L
K
-----------------
E
R
P
--------------
K
-------------
E
--
E
I
L
----
R
R
M
A
E
V
D
-------------
R
A
-----------
R
-
K
G
--
Q
P
-----
K
R
K
S
A
G
C
A
F
K
N
P
-----------------------
P
G
--------------------------
Q
---------
S
---
A
G
R
L
I
D
E
R
G
L
K
G
L
R
V
G
D
A
M
I
S
L
E
H
G
N
F
I
V
N
L
G
Q
A
R
A
K
D
V
L
E
L
V
R
R
V
Q
E
E
----
L
P
L
E
L
E
W
E
V
W
----------
4
PsiBlast_PDB
66.92
36%
-80
- C2 -
2GQT
2
MURB_THET8
A:
[11-255]
----------------------
L
K
D
Y
T
T
L
G
V
G
G
P
A
E
L
W
----
T
V
E
T
R
--
E
E
L
---
K
R
A
T
E
A
P
Y
R
V
L
G
N
G
S
N
L
L
V
-
L
---
D
E
G
V
P
E
R
V
I
R
L
A
---
G
E
-
F
Q
T
Y
D
L
----
K
G
----
W
---
V
G
A
G
T
L
-
L
P
L
L
V
Q
E
A
A
R
A
G
L
S
G
L
E
G
L
L
G
I
P
A
Q
V
G
G
A
V
K
M
N
A
G
T
R
F
G
E
M
A
D
A
L
E
-
A
V
E
V
F
---
H
-
D
G
A
F
H
V
Y
C
P
E
E
L
G
F
G
Y
R
---
K
S
H
L
P
P
---
G
G
----
I
V
T
R
V
R
L
K
L
K
-----------------
E
R
P
--------------
K
-------------
E
--
E
I
L
----
R
R
M
A
E
V
D
-------------
R
A
-----------
R
K
G
---
Q
P
-----
K
R
K
S
A
G
C
A
F
K
N
P
-----------------------
P
G
--------------------------
Q
---------
S
---
A
G
R
L
I
D
E
R
G
L
K
G
L
R
V
G
D
A
M
I
S
L
E
H
G
N
F
I
V
N
L
G
Q
A
R
A
K
D
V
L
E
L
V
R
R
V
Q
--------------------------
5
PsiBlast_PDB
66.64
36%
-80
- C2 -
2GQU
2
MURB_THET8
A:
[11-255]
----------------------
L
K
D
Y
T
T
L
G
V
G
G
P
A
E
L
W
----
T
V
E
T
R
--
E
E
L
---
K
R
A
T
E
A
P
Y
R
V
L
G
N
G
S
N
L
L
V
-
L
---
D
E
G
V
P
E
R
V
I
R
L
A
---
G
E
-
F
Q
T
Y
D
L
----
K
G
----
W
---
V
G
A
G
T
L
-
L
P
L
L
V
Q
E
A
A
R
A
G
L
S
G
L
E
G
L
L
G
I
P
A
Q
V
G
G
A
V
K
M
N
A
G
T
R
F
G
E
M
A
D
A
L
E
-
A
V
E
V
F
---
H
-
D
G
A
F
H
V
Y
C
P
E
E
L
G
F
G
Y
R
---
K
S
H
L
P
P
---
G
G
----
I
V
T
R
V
R
L
K
L
K
-----------------
E
R
P
--------------
K
-------------
E
--
E
I
L
----
R
R
M
A
E
V
D
-------------
R
A
-----------
R
K
G
---
Q
P
-----
K
R
K
S
A
G
C
A
F
K
N
P
-----------------------
P
G
--------------------------
Q
---------
S
---
A
G
R
L
I
D
E
R
G
L
K
G
L
R
V
G
D
A
M
I
S
L
E
H
G
N
F
I
V
N
L
G
Q
A
R
A
K
D
V
L
E
L
V
R
R
V
Q
--------------------------
52
Fugue
55.36
71%
-95
- C2 -
1HSK
1
MURB_STAAU
A:
[209-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
--------------
M
-------------
T
--
E
I
Q
----
A
K
M
D
D
L
T
-------------
E
R
-----------
R
E
S
K
--
Q
P
LE----
Y
P
S
C
G
S
V
F
Q
R
P
-----------------------
P
G
--------------------------
H
---------
F
---
A
G
K
L
I
Q
D
S
N
L
Q
G
H
R
I
G
G
V
E
V
S
T
K
H
A
G
F
M
V
N
V
D
N
G
T
A
T
D
Y
E
N
L
I
H
Y
V
Q
K
T
V
K
E
K
F
G
I
E
L
N
R
E
V
R
I
I
G
---
E
H
P
K