@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1433: (2016-03-24 )
VAKFTYDVVIIGSGASGTTVAFEAQAAGLKVAIVEERNWGGTCVLRGCDPKKVLIGAREARNLSTRLRGKGIKQAATISWTDLMAFKETFVENVPESRLASFQEAGIETFFGAASFQDSHSLQVGDDLIYAEKIVIATGATPSTLKVEGKEYIQTSDDFLSLEKLPDSVVFIGGGYISFEFASIALAAGRDVHIIHHNSEPLKKFDPDFVAALVANIKDEGIHFHFDTDITKIENDGGKLHIKGKDSFSLQTDLIIGATGRMPNIAHLSLENASIDYTKKGIVVNEKLQTPNNPHIYACGDVAATKGAPLTPVVSLEAALVAKNVIGVNEKITYPAIPSVVFTSPKLASIGISTEEAKANPEKYQIKNHDTTSWYTYKRTNEQIALAKIIEDRESGQIKGAHFLSEEADYMINYIAILMKANLTLADLQSVIFAYPSPASDLTALN
Atome Classification :
(20 SA)
.........10........20......-..30......-.---------.40........50....-..------..60....-..-..70.---.-.--....-.80........90........100...-....110.......120..--.--.----.-----.---------...130.......140....---.-...150.------........160.-......170.......180..---...---..190.......200.......210.......-220.......230.-.-...-..240-.---..-----.--..------..-250-.......260.......270.......280........290.......300....-...310.......320....-...--330..--......340.......350.......360-----------.-.-..-.....370.-......380.......390.......400.......410.......420.......430.......440....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
VA
K
F
T
Y
D
V
V
I
I
GSGASG
T
T
V
A
F
E
AQAA-
G
L
K
V
A
I
V
E
ER-N---------WG
G
T
C
V
LRGC
D
P
K
K
V
L
I
-G
A
------
R
E
A
R
N
L
S
T
-
R
L
-RGKGI---K-
Q
--
A
A
T
I
-
S
W
T
D
L
M
A
F
K
E
T
F
V
E
NV
P
E
S
R
L
A
S
F
Q
E
A-G
I
E
T
F
FGAASFQDSH--SL--Q--V----G-----D---------D
L
I
Y
A
E
K
I
V
I
ATGA-TP
S
T
L
---
K
-VE
G
K
--
E
------YIQTS
D
D
F
L
S
L
E
-KLPD
S
V
V
F
IGG
G
Y
I
S
F
E
F
A
S
I
---
A
LA---AG
R
D
V
H
I
I
HHNSE
P
L
K
KF
D
P
D
F
V
A
A
L
V
A
NIKD-E
G
I
H
F
H
FDTD
I
T
K
I-E-NDG-
G
K
L
H
--
I
---KG-----K--DS------F
S
-
L
QT-
D
L
I
I
GATGRMP
N
I
A
H
L
S
LENASIDYTKK
G
-
I
V
V
N
E
KLQTPNN
P
H
I
Y
ACGDVAATK-GAPLTP
V
V
S
L
E
A
A
L
V
A
K
N
VI-GVN--E-KIT--YPAIPS
V
V
FTSP
K
L
A
SIGIS
T
E
EAKAN-------------P-E-
K
Y
-
Q
I
KNHDTT
S
-
W
Y
T
Y
KRTN
E
Q
I
A
L
A
K
I
I
E
DRESGQIKGAHFLSEE
A
D
Y
M
I
N
Y
I
A
I
L
M
KAN
L
T
L
A
D
L
Q
S
V
I
FAYPSPASDLTALN
23
HHSearch
96.55
31%
-95
- C1 -
3O0H
4
?
A:
[24-469]
--
S
F
D
F
D
L
F
V
I
G
S
G
S
G
G
V
R
A
A
R
L
A
G
A
L
-
G
K
R
V
A
I
A
E
E
Y
-
R
---------
I
G
G
T
C
V
I
R
G
C
V
P
K
K
L
Y
F
-
Y
A
------
S
Q
Y
A
Q
E
F
S
-
K
S
-
I
G
F
G
W
---
K
-
Y
A-
D
P
I
F
-
N
W
E
K
L
V
A
A
K
N
K
E
I
S
R
L
E
G
L
Y
R
E
G
L
Q
N
S
-
N
V
H
I
Y
E
S
R
A
V
F
V
D
E
H
--
T
L
E
L
S
--
V
----
T
-----
G
---------
E
R
I
S
A
E
K
I
L
I
A
T
G
A
-
K
I
V
S
N
-----
I
K
G
S
--
D
------
L
C
L
T
S
N
E
I
F
D
L
E
-
K
L
P
K
S
I
V
I
V
G
G
G
Y
I
G
V
E
F
A
N
I
---
F
H
G
---
L
G
V
K
T
T
L
L
H
R
G
D
L
I
L
R
N
F
D
Y
D
L
R
Q
L
L
N
D
A
M
V
A
-
K
G
I
S
I
I
Y
E
A
T
V
S
Q
V
-
Q
-
S
T
E
-
N
C
Y
N
--
V
---
V
L
-----
T
--
N
G
------
Q
T
-
I
C
A
-
D
R
V
M
L
A
T
G
R
V
P
N
T
T
G
L
G
L
E
R
A
G
V
K
V
N
E
F
G
A
V
V
V
D
E
K
M
T
-
T
N
V
S
H
I
W
A
V
G
D
V
T
--
G
-
H
I
Q
L
T
P
V
A
I
H
D
A
M
C
F
V
K
N
A
F
-
E
-----T
T
P
D
--
Y
D
L
I
T
T
A
V
F
S
Q
P
E
I
G
T
V
G
L
S
E
E
D
A
L
H
R
-------------
Y
-
K
-
R
V
-
E
I
Y
R
T
V
F
R
P
-
M
R
N
V
L
S
G
S
P
E
K
M
F
M
K
L
V
V
D
G
E
S
R
I
V
V
G
A
H
V
L
G
E
N
A
G
E
I
A
Q
L
I
G
I
S
L
K
G
K
L
T
K
D
I
F
D
K
T
M
A
V
H
P
T
M
S
E
E
L
V
T
M
-
2
PsiBlast_PDB
93.66
31%
-89
- C1 -
3O0H
4
?
A:
[24-469]
--
S
F
D
F
D
L
F
V
I
G
S
G
S
G
G
V
R
A
A
R
L
A
G
A
L
-
G
K
R
V
A
I
A
E
E
Y
-
R
---------
I
G
G
T
C
V
I
R
G
C
V
P
K
K
L
Y
F
-
Y
A
------
S
Q
Y
A
Q
E
F
S
-
K
S
-
I
G
F
G
W
---
K
-
Y
--
A
D
P
I
F
N
W
E
K
L
V
A
A
K
N
K
E
I
S
R
L
E
G
L
Y
R
E
G
L
Q
N
S
-
N
V
H
I
Y
E
S
R
A
V
F
V
D
E
H
--
T
L
--
E
L
S
V
----
T
-----
G
---------
E
R
I
S
A
E
K
I
L
I
A
T
G
A
K
I
V
S
N
------
I
K
G
S
--
D
------
L
C
L
T
S
N
E
I
F
D
L
E
-
K
L
P
K
S
I
V
I
V
G
G
G
Y
I
G
V
E
F
A
N
I
---
F
H
G
---
L
G
V
K
T
T
L
L
H
R
G
D
L
I
L
R
N
F
D
Y
D
L
R
Q
L
L
N
D
A
M
V
A
-
K
G
I
S
I
I
Y
E
A
T
V
S
Q
V
-
Q
-
S
T
E
-
N
C
Y
N
--
V
---
V
L
-----
T
--
N
G
------
Q
T
-
I
C
A
-
D
R
V
M
L
A
T
G
R
V
P
N
T
T
G
L
G
L
E
R
A
G
V
K
V
N
E
F
G
-
A
V
V
V
D
E
K
M
T
T
N
V
S
H
I
W
A
V
G
D
V
--
T
G
-
H
I
Q
L
T
P
V
A
I
H
D
A
M
C
F
V
K
N
A
F
-
E
-------
T
T
PD
Y
D
L
I
T
T
A
V
F
S
Q
P
E
I
G
T
V
G
L
S
E
E
D
A
L
H
R
-------------
Y
-
K
-
R
V
-
E
I
Y
R
T
V
F
R
P
-
M
R
N
V
L
S
G
S
P
E
K
M
F
M
K
L
V
V
D
G
E
S
R
I
V
V
G
A
H
V
L
G
E
N
A
G
E
I
A
Q
L
I
G
I
S
L
K
G
K
L
T
K
D
I
F
D
K
T
M
A
V
H
P
T
M
S
E
E
L
V
T
M
-
22
HHSearch
92.74
29%
-86
- C1 -
1GES
2
GSHR_ECOLI
A:
[3-449]
---
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
I
E
A
K
-
E
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
-
H
A
------
A
Q
I
R
E
A
I
H
-
M
Y
G
P
D
Y
G
F
---
D
-
T
T-
I
N
K
F
-
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
L
G
K
N
-
N
V
D
V
I
K
G
F
A
R
F
V
D
A
K
--
T
L
--
E
--
V
----
N
-----
G
---------
E
T
I
T
A
D
H
I
L
I
A
T
G
G
-
R
P
S
H
P
---
D
-
I
P
G
V
--
E
------
Y
G
I
D
S
D
G
F
F
A
L
P
-
A
L
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
---
I
N
G
---
L
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
-
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
-
V
-
K
N
T
D
G
S
L
T
--
L
---
E
L
-----
E
--
D
G
------
R
S
-
E
T
V
-
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
N
E
K
G
Y
I
V
V
D
K
Y
Q
N
-
T
N
I
E
G
I
Y
A
V
G
D
N
T
--
G
-
A
V
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
-
N
N
K
PD
E
-
H
L
D
--
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y------------
G
D
D
-
Q
V
-
K
V
Y
K
S
S
F
T
A
-
M
Y
T
A
V
T
T
H
R
Q
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
-
39
HHSearch
90.10
28%
-88
- C1 -
2YQU
4
?
A:
[1-444]
----
M
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
-
G
M
K
V
G
V
V
E
K
E
K
A
---------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
-
E
T
------
T
E
R
I
Y
E
A
K
K
G
L
-
L
G
A
K
V
---
K
----
G
V
E
L
-
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
-
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
--
K
V
--
L
--
V
EE--
T
-----
G
---------
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
-
A
P
L
I
P
---
P
-
W
A
Q
V
--
D
YER---
V
-
V
T
S
T
E
A
L
S
F
P
-
E
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
---
W
H
R
---
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
-
V
-
P
E
A
-
K
G
A
R
--
V
---
E
L
-----
E
--
G
G
------
E
V
-
L
E
A
-
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
-
T
R
V
P
H
I
Y
A
I
G
D
V
V
--
R
-
G
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
-
R
G
F
--
G
-
H
V
D
--
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
-------------
G
-
I
-
P
Y
-
K
V
G
K
F
P
Y
S
A
-
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
-
31
HHSearch
89.72
29%
-89
- C1 -
3URH
3
?
A:
[26-480]
-----
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
-
G
M
K
V
A
V
V
E
K
R
S
T
---------
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
A
------
S
E
M
F
H
Q
A
Q
H
G
L
-
E
A
L
G
V
---
E
-
V
A
-
N
P
K
L
-
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
N
-
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
--
K
V
--
S
--
V
----
T
N
EKG
E
E
---------
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
-
D
V
A
G
------
I
P
G
V
--
E
V
A
F
DEK
T
I
V
S
S
T
G
A
L
A
L
E
-
K
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
---
W
A
R
---
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
G
A
-
V
-
K
S
G
-
D
G
A
K
--
V
---
T
F
E
PV--
K
G
G
E
A
------
T
T
-
L
D
A
-
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
-
T
S
I
A
G
V
Y
A
I
G
D
V
V
--
R
-
G
P
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
-
G
Q
A
--
G
-
H
V
N
--
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
-------------
G
-
V
-
A
Y
-
K
I
G
K
F
P
F
T
A
-
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
-
37
HHSearch
87.27
27%
-85
- C1 -
3DK9
4
GSHR_HUMAN
A:
[17-477]
-
A
V
A
S
Y
D
Y
L
V
I
G
G
G
S
G
G
L
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
S
H
-
K
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
-
N
T
------
A
V
H
S
E
F
M
H
-
D
H
-
A
D
Y
G
F
---
P
-
S
C-
E
G
K
F
-
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
L
T
K
S
-
H
I
E
I
I
R
G
H
A
A
F
T
S
D
P
K
P
T
I
--
E
--
V
----
S
-----
G
---------
K
K
Y
T
A
P
H
I
L
I
A
T
G
G
-
M
P
S
T
P
H
ES
Q
-
I
P
G
A
--
S
------
L
G
I
T
S
D
G
F
F
Q
L
E
-
E
L
P
G
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
---
L
S
A
---
L
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
-
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
-
K
-
K
T
L
-
S
G
L
E
--
V
S
M
V
T
A
-----
V
--
P
G
R
L
P
V
M
T
M
I
-
P
D
V
-
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
D
D
K
G
H
I
I
V
D
E
F
Q
N
-
T
N
V
K
G
I
Y
A
V
G
D
V
C
--
G
-
K
A
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
-
E
Y
K
ED
S
-
K
L
D
--
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y------------
G
-
I
E
N
V
-
K
T
Y
S
T
S
F
T
P
-
M
Y
H
A
V
T
K
R
K
T
K
C
V
M
K
M
V
C
A
N
K
E
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
-
26
HHSearch
86.13
28%
-85
* C1 *
2EQ6
2
?
A:
[4-450]
--
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
-
G
L
K
V
L
A
V
E
A
G
-
E
---------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
-
H
A
------
A
E
T
L
H
H
L
K
-
V
A
-
E
G
F
G
L
---
K
-
A
--
K
P
E
L
-
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
-
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
--
E
V
--
E
--
V
----
G
-----
G
---------
E
R
Y
G
A
K
S
L
I
L
A
T
G
S
-
E
P
L
E
L
---
K
G
F
P
F
G
E-
D
------
V
-
W
D
S
T
R
A
L
K
V
E
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
---
Y
R
R
---
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
-
E
-
K
K
K
-
D
G
L
H
--
V
---
R
L
E
PAEG
G
--
E
G
------
E
E
-
V
V
V
-
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
-
T
S
V
P
G
V
Y
A
I
G
D
A
A
--
R
-
P
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
-
G
K
D
--
S
-
A
F
D
--
Y
-
Q
V
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
-------------
G
-
Y
-
K
V
-
K
V
G
K
F
P
L
A
A
-
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
-
34
HHSearch
86.10
27%
-89
- C1 -
1EBD
2
DLDH1_GEOSE
A:
[2-450]
---
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
-
G
Q
K
V
T
I
V
E
K
G
-
N
---------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
-
S
A
------
S
H
R
Y
E
Q
A
K
-
H
S
-
E
E
M
G
I
---
K
-
A
E
-
N
V
T
I
-
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
-
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
--
T
V
--
R
--
V
V
N
GD
S
-----
A
---------
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
-
R
P
I
E
L
---
P
-
N
F
K
F
SN
R
------
I
-
L
D
S
T
G
A
L
N
L
G
-
E
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
---
Y
A
N
---
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
-
E
-
E
R
E
-
D
G
V
T
--
V
---
T
Y
E
----
A
--
N
G
E
T
----
K
T
-
I
D
A
-
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
-
T
S
V
P
N
I
F
A
I
G
D
I
V
--
P
-
G
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
-
G
H
P
--
S
-
A
V
D
--
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
-------------
G
-
I
-
D
V
-
I
A
A
K
F
P
F
A
A
-
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
-
40
HHSearch
85.69
30%
-80
- C1 -
2R9Z
8
GASHR_MARGR
A:
[2-447]
--
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
A
V
A
E
K
A
A
A
F
-
G
K
R
V
A
L
I
E
S
K
-
A
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
-
Y
A
------
S
H
L
A
E
A
V
R
-
D
A
-
P
G
F
G
V
---
Q
-
A
S----
L
-
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
V
E
R
L
-
G
I
T
R
V
D
G
H
A
R
F
V
D
A
H
--
T
I
--
E
--
V
----
E
-----
G
---------
Q
R
L
S
A
D
H
I
V
I
A
T
G
G
-
R
P
I
V
P
---
R
-
L
P
G
A
--
E
------
L
G
I
T
S
D
G
F
F
A
L
Q
-
Q
Q
P
K
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
---
L
R
S
---
F
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
-
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
-
E
-
R
D
A
-
Q
G
T
T
--
L
---
V
A
-----
Q
--
D
G
------
T
R
L
E
G
F
-
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
M
V
P
T
D
A
Y
Q
N
-
T
N
V
P
G
V
Y
A
L
G
D
I
T
--
G
-
R
D
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
F
-
D
G
Q
SE
R
-
K
L
D
--
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
-------------
L
-
G
-
D
V
L
T
V
Y
E
T
S
F
T
P
-
M
R
Y
A
L
N
E
H
G
P
K
T
A
M
K
L
V
C
A
G
P
E
Q
R
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
G
S
A
E
E
L
V
T
L
-
16
PsiBlast_PDB
85.39
27%
-89
- C1 -
2WOW
5
?
A:
[8-474]
-----
F
D
L
V
V
I
G
A
G
S
G
G
L
E
A
G
W
N
A
A
T
L
Y
G
K
R
V
A
V
V
D
V
Q
-
T
S
H
G
P
PFYAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
H
L
R
E
S
A
G
F
G
W
-
E
F
-
D
G
S
S
V
---
K
-
A
-------
N
W
K
K
L
I
A
A
K
N
E
A
V
L
D
I
N
K
S
Y
E
G
M
F
N
D
T
E
G
L
D
F
F
L
G
W
G
S
L
E
S
K
N
--
V
V
--
V
--
V
----
R
-----
E
TADPKSAVK
E
R
L
Q
A
D
H
I
L
L
A
T
G
S
-
W
P
Q
M
P
---
A
-
I
P
G
I
--
E
------
H
C
I
S
S
N
E
A
F
Y
L
P
-
E
P
P
R
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
---
F
N
A
Y
KP
P
G
G
K
V
T
L
C
Y
R
N
N
L
I
L
R
G
F
D
E
T
I
R
E
E
V
T
K
Q
L
T
A
-
N
G
I
E
I
M
T
N
E
N
P
A
K
V
-
S
L
N
T
D
-
G
S
K
H
--
V
---
T
F
-----
E
--
S
G
------
K
T
-
L
D
V
-
D
V
V
M
M
A
I
G
R
I
P
R
T
N
D
L
Q
L
G
N
V
G
V
K
L
T
P
K
G
-
G
V
Q
V
D
E
F
S
R
T
N
V
P
N
I
Y
A
I
G
D
I
--
T
D
-
R
L
M
L
T
P
V
A
I
N
E
G
A
A
L
V
D
T
V
F
-
G
N
K
--
P
-
R
K
T
D
-
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
A
K
E
-------------
F
-
E
-
K
V
-
A
V
Y
M
S
S
F
T
P
L
M
H
N
I
S
G
S
K
Y
K
K
F
V
A
K
I
V
T
N
H
S
D
G
T
V
L
G
V
H
L
L
G
D
G
A
P
E
I
I
Q
A
V
G
V
C
L
R
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
-
8
PsiBlast_PDB
84.95
28%
-82
- C1 -
2W0H
6
?
A:
[25-491]
-----
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
-
A
THGPPLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
-
T
G
------
A
Q
Y
M
D
L
I
R
-
E
S
-
G
G
F
G
W
EMD
R
-
E
--
S
L
C
P
-
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
E
G
L
S
F
H
M
G
F
G
A
L
Q
D
A
H
--
T
V
--
V
--
V
----
R
-----
K
SEDPHSDVL
E
T
L
D
T
E
Y
I
L
I
A
T
G
S
-
W
P
T
R
L
---
G
-
V
P
G
D
--
E
------
F
C
I
T
S
N
E
A
F
Y
L
E
-
D
A
P
K
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
K
P
---
C
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
-
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
-
N
E
D
-
G
S
N
H
--
V
---
H
F
-----
N
--
D
G
------
T
E
-
E
D
Y
-
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
-
A
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
V
--
T
N
-
R
V
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
F
-
G
G
K
--
P
-
R
A
T
D-
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
-------------
Y
-
E
-
T
V
-
A
V
Y
A
S
S
F
T
P
L
M
H
N
I
S
G
S
K
H
K
E
F
M
I
R
I
I
T
N
E
S
N
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
-
15
PsiBlast_PDB
84.77
27%
-89
- C1 -
2WOV
4
?
A:
[8-474]
-----
F
D
L
V
V
I
G
A
G
S
G
G
L
E
A
G
W
N
A
A
T
L
Y
G
K
R
V
A
V
V
D
V
Q
-
T
SHGPPFYAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
H
L
R
E
S
A
G
F
G
W
-
E
F
-
D
G
S
S
V
---
K
-
A
-------
N
W
K
K
L
I
A
A
K
N
E
A
V
L
D
I
N
K
S
Y
E
G
M
F
N
D
T
E
G
L
D
F
F
L
G
W
G
S
L
E
S
K
N
--
V
V
--
V
--
V
----
R
-----
E
TADPKSAVK
E
R
L
Q
A
D
H
I
L
L
A
T
G
S
-
W
P
Q
M
P
---
A
-
I
P
G
I
--
E
------
H
C
I
S
S
N
E
A
F
Y
L
P
-
E
P
P
R
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
---
F
N
A
Y
KP
P
G
G
K
V
T
L
C
Y
R
N
N
L
I
L
R
G
F
D
E
T
I
R
E
E
V
T
K
Q
L
T
A
-
N
G
I
E
I
M
T
N
E
N
P
A
K
V
-
S
L
N
T
D
-
G
S
K
H
--
V
---
T
F
-----
E
--
S
G
------
K
T
-
L
D
V
-
D
V
V
M
M
A
I
G
R
I
P
R
T
N
D
L
Q
L
G
N
V
G
V
K
L
T
P
K
G
-
G
V
Q
V
D
E
F
S
R
T
N
V
P
N
I
Y
A
I
G
D
I
--
T
D
-
R
L
M
L
T
P
V
A
I
N
E
G
A
A
L
V
D
T
V
F
-
G
N
K
--
P
-
R
K
T
D
-
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
A
K
E
-------------
F
-
E
-
K
V
-
A
V
Y
M
S
S
F
T
P
L
M
H
N
I
S
G
S
K
Y
K
K
F
V
A
K
I
V
T
N
H
S
D
G
T
V
L
G
V
H
L
L
G
D
G
A
P
E
I
I
Q
A
V
G
V
C
L
R
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
-
12
PsiBlast_PDB
84.49
28%
-84
- C1 -
2X50
8
?
A:
[25-491]
-----
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
-
A
T
H
G
P
PLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
-
T
G
------
A
Q
Y
M
D
L
I
R
-
E
S
-
G
G
F
G
W
EMD
R
-
E
--
S
L
C
P
-
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
E
G
L
S
F
H
M
G
F
G
A
L
Q
D
A
H
--
T
V
--
V
--
V
----
R
-----
K
SEDPHSDVL
E
T
L
D
T
E
Y
I
L
I
A
T
G
S
-
W
P
T
R
L
---
G
-
V
P
G
D
--
E
------
F
C
I
T
S
N
E
A
F
Y
L
E
-
D
A
P
K
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
K
P
---
C
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
-
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
-
N
E
D
-
G
S
N
H
--
V
---
H
F
-----
N
--
D
G
------
T
E
-
E
D
Y
-
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
-
A
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
V
--
T
N
-
R
V
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
F
-
G
G
K
--
P
-
R
A
T
D
-
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
-------------
Y
-
E
-
T
V
-
A
V
Y
A
S
S
F
T
P
L
M
H
N
I
S
G
S
K
H
K
E
F
M
I
R
I
I
T
N
E
S
N
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
-
9
PsiBlast_PDB
84.40
28%
-85
- C1 -
2YAU
9
?
A:
[25-491]
-----
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
-
A
THGPPLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
-
T
G
------
A
Q
Y
M
D
L
I
R
-
E
S
-
G
G
F
G
W
EMD
R
-
E
--
S
L
C
P
-
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
E
G
L
S
F
H
M
G
F
G
A
L
Q
D
A
H
--
T
V
--
V
--
V
----
R
-----
K
SEDPHSDVL
E
T
L
D
T
E
Y
I
L
I
A
T
G
S
-
W
P
T
R
L
---
G
-
V
P
G
D
--
E
------
F
C
I
T
S
N
E
A
F
Y
L
E
-
D
A
P
K
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
K
P
---
C
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
-
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
-
N
E
D
-
G
S
N
H
--
V
---
H
F
-----
N
--
D
G
------
T
E
-
E
D
Y
-
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
-
A
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
V
--
T
N
-
R
V
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
F
-
G
G
K
--
P
-
R
A
T
D
-
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
-------------
Y
-
E
-
T
V
-
A
V
Y
A
S
S
F
T
P
L
M
H
N
I
S
G
S
K
H
K
E
F
M
I
R
I
I
T
N
E
S
N
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
-
1
PsiBlast_PDB
84.32
30%
-82
- C1 -
2R9Z
8
GASHR_MARGR
A:
[5-448]
-----
F
D
L
I
A
I
G
G
G
S
G
G
L
A
V
A
E
K
A
A
A
F
-
G
K
R
V
A
L
I
E
S
K
-
A
---------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
-
Y
A
------
S
H
L
A
E
A
V
R
-
D
A
-
P
G
F
G
V
---
Q
A
S
-----
L
-
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
V
E
R
L
-
G
I
T
R
V
D
G
H
A
R
F
V
D
A
H
--
T
I
--
E
--
V
----
E
-----
G
---------
Q
R
L
S
A
D
H
I
V
I
A
T
G
G
-
R
P
I
V
P
---
R
-
L
P
G
A
--
E
------
L
G
I
T
S
D
G
F
F
A
L
Q
-
Q
Q
P
K
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
---
L
R
S
---
F
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
-
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
-
E
-
R
D
A
-
Q
G
T
T
--
L
---
V
A
-----
Q
--
D
G
------
T
R
-
L
E
G
F
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
Q
S
N
G
-
M
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
I
--
T
G
-
R
D
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
F
D
G
Q
S
--
E
R
K
L
D
--
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
LGDV
L
T
V
Y
E
T
S
F
T
P
-
M
-
R
Y
-
A
L
N
E
H
------------
G
P
K
T
A
M
K
L
V
C
A
G
P
E
Q
-
R
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
G
S
A
E
E
L
V
T
L
K
14
PsiBlast_PDB
84.25
27%
-86
- C1 -
2WOI
5
?
A:
[8-474]
-----
F
D
L
V
V
I
G
A
G
S
G
G
L
E
A
G
W
N
A
A
T
L
Y
G
K
R
V
A
V
V
D
V
Q
-
T
SHGPPFYAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
H
L
R
E
S
A
G
F
G
W
-
E
F
-
D
G
S
S
V
---
K
-
A
-------
N
W
K
K
L
I
A
A
K
N
E
A
V
L
D
I
N
K
S
Y
E
G
M
F
N
D
T
E
G
L
D
F
F
L
G
W
G
S
L
E
S
K
N
--
V
V
--
V
--
V
----
R
-----
E
TADPKSAVK
E
R
L
Q
A
D
H
I
L
L
A
T
G
S
-
W
P
Q
M
P
---
A
-
I
P
G
I
--
E
------
H
C
I
S
S
N
E
A
F
Y
L
P
-
E
P
P
R
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
---
F
N
A
Y
KP
P
G
G
K
V
T
L
C
Y
R
N
N
L
I
L
R
G
F
D
E
T
I
R
E
E
V
T
K
Q
L
T
A
-
N
G
I
E
I
M
T
N
E
N
P
A
K
V
-
S
L
N
T
D
-
G
S
K
H
--
V
---
T
F
-----
E
--
S
G
------
K
T
-
L
D
V
-
D
V
V
M
M
A
I
G
R
I
P
R
T
N
D
L
Q
L
G
N
V
G
V
K
L
T
P
K
G
-
G
V
Q
V
D
E
F
S
R
T
N
V
P
N
I
Y
A
I
G
D
I
--
T
D
-
R
L
M
L
T
P
V
A
I
N
E
G
A
A
L
V
D
T
V
F
-
G
N
K
--
P
-
R
K
T
D
-
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
A
K
E
-------------
F
-
E
-
K
V
-
A
V
Y
M
S
S
F
T
P
L
M
H
N
I
S
G
S
K
Y
K
K
F
V
A
K
I
V
T
N
H
S
D
G
T
V
L
G
V
H
L
L
G
D
G
A
P
E
I
I
Q
A
V
G
V
C
L
R
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
-
24
HHSearch
83.96
26%
-88
- C1 -
2QAE
2
DLDH_TRYCR
A:
[1-457]
---
N
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
-
G
M
K
T
A
C
V
E
K
R
G
A
---------
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
-
H
A
------
T
H
L
Y
H
D
A
H
A
N
F
-
A
R
Y
G
L
---
M
-
G
GE
G
V
T
M
-
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
N
-
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
--
S
I
--
R
--
V
----
N
GLDG
K
Q
---------
E
M
L
E
T
K
K
T
I
I
A
T
G
S
-
E
P
T
E
L
---
P
-
F
L
P
F
--
D
EK----
V
V
L
S
S
T
G
A
L
A
L
P
-
R
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
---
W
A
R
---
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
E
K
M
K
F
M
T
S
T
K
V
V
G
G
-
T
-
N
N
G
-
D
S
V
S
L
E
V
---
E
G
-----
K
----
R
-----
E
T
-
V
T
C
-
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
-
T
S
I
P
D
V
Y
A
I
G
D
V
V
--
D
K
G
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
-
G
K
P
--
G
-
H
V
N
--
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
-------------
G
-
V
-
A
Y
-
K
V
G
K
F
P
F
N
A
-
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
-
20
PsiBlast_PDB
83.93
27%
-86
- C1 -
2WPE
9
?
A:
[8-474]
-----
F
D
L
V
V
I
G
A
G
S
G
G
L
E
A
G
W
N
A
A
T
L
Y
G
K
R
V
A
V
V
D
V
Q
-
T
S
H
G
P
PFYAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
H
L
R
E
S
A
G
F
G
W
-
E
F
-
D
G
S
S
V
---
K
-
A
-------
N
W
K
K
L
I
A
A
K
N
E
A
V
L
D
I
N
K
S
Y
E
G
M
F
N
D
T
E
G
L
D
F
F
L
G
W
G
S
L
E
S
K
N
--
V
V
--
V
--
V
----
R
-----
E
TADPKSAVK
E
R
L
Q
A
D
H
I
L
L
A
T
G
S
-
W
P
Q
M
P
---
A
-
I
P
G
I
--
E
------
H
C
I
S
S
N
E
A
F
Y
L
P
-
E
P
P
R
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
---
F
N
A
Y
KP
P
G
G
K
V
T
L
C
Y
R
N
N
L
I
L
R
G
F
D
E
T
I
R
E
E
V
T
K
Q
L
T
A
-
N
G
I
E
I
M
T
N
E
N
P
A
K
V
-
S
L
N
T
D
-
G
S
K
H
--
V
---
T
F
-----
E
--
S
G
------
K
T
-
L
D
V
-
D
V
V
M
M
A
I
G
R
I
P
R
T
N
D
L
Q
L
G
N
V
G
V
K
L
T
P
K
G
-
G
V
Q
V
D
E
F
S
R
T
N
V
P
N
I
Y
A
I
G
D
I
--
T
D
-
R
L
M
L
T
P
V
A
I
N
E
G
A
A
L
V
D
T
V
F
-
G
N
K
--
P
-
R
K
T
D
-
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
A
K
E
-------------
F
-
E
-
K
V
-
A
V
Y
M
S
S
F
T
P
L
M
H
N
I
S
G
S
K
Y
K
K
F
V
A
K
I
V
T
N
H
S
D
G
T
V
L
G
V
H
L
L
G
D
G
A
P
E
I
I
Q
A
V
G
V
C
L
R
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
-
11
PsiBlast_PDB
83.54
28%
-84
- C1 -
4APN
7
?
A:
[25-491]
-----
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
K
K
K
V
A
V
V
D
V
Q
-
A
T
H
G
P
PLFAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
-
T
G
------
A
Q
Y
M
D
L
I
R
-
E
S
-
G
G
F
G
W
E
M
D
R
-
E
--
S
L
C
P
-
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
F
A
D
T
E
G
L
S
F
H
M
G
F
G
A
L
Q
D
A
H
--
T
V
--
V
--
V
----
R
-----
K
SEDPHSDVL
E
T
L
D
T
E
Y
I
L
I
A
T
G
S
-
W
P
T
R
L
---
G
-
V
P
G
D
--
E
------
F
C
I
T
S
N
E
A
F
Y
L
E
-
D
A
P
K
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
K
P
---
C
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
-
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
-
N
E
D
-
G
S
N
H
--
V
---
H
F
-----
N
--
D
G
------
T
E
-
E
D
Y
-
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
G
K
N
G
-
A
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
V
--
T
N
-
R
V
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
F
-
G
G
K
--
P
-
R
A
T
D-
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
-------------
Y
-
E
-
T
V
-
A
V
Y
A
S
S
F
T
P
L
M
H
N
I
S
G
S
K
H
K
E
F
M
I
R
I
I
T
N
E
S
N
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
-
19
PsiBlast_PDB
83.45
27%
-87
- C1 -
2WPC
8
?
A:
[8-474]
-----
F
D
L
V
V
I
G
A
G
S
G
G
L
E
A
G
W
N
A
A
T
L
Y
G
K
R
V
A
V
V
D
V
Q
-
T
S
H
G
P
PFYAA
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
H
L
R
E
S
A
G
F
G
W
-
E
F
-
D
G
S
S
V
---
K
-
A
-------
N
W
K
K
L
I
A
A
K
N
E
A
V
L
D
I
N
K
S
Y
E
G
M
F
N
D
T
E
G
L
D
F
F
L
G
W
G
S
L
E
S
K
N
--
V
V
--
V
--
V
----
R
-----
E
TADPKSAVK
E
R
L
Q
A
D
H
I
L
L
A
T
G
S
-
W
P
Q
M
P
---
A
-
I
P
G
I
--
E
------
H
C
I
S
S
N
E
A
F
Y
L
P
-
E
P
P
R
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
---
F
N
A
Y
KP
P
G
G
K
V
T
L
C
Y
R
N
N
L
I
L
R
G
F
D
E
T
I
R
E
E
V
T
K
Q
L
T
A
-
N
G
I
E
I
M
T
N
E
N
P
A
K
V
-
S
L
N
T
D
-
G
S
K
H
--
V
---
T
F
-----
E
--
S
G
------
K
T
-
L
D
V
-
D
V
V
M
M
A
I
G
R
I
P
R
T
N
D
L
Q
L
G
N
V
G
V
K
L
T
P
K
G
-
G
V
Q
V
D
E
F
S
R
T
N
V
P
N
I
Y
A
I
G
D
I
--
T
D
-
R
L
M
L
T
P
V
A
I
N
E
G
A
A
L
V
D
T
V
F
-
G
N
K
--
P
-
R
K
T
D
-
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
A
K
E
-------------
F
-
E
-
K
V
-
A
V
Y
M
S
S
F
T
P
L
M
H
N
I
S
G
S
K
Y
K
K
F
V
A
K
I
V
T
N
H
S
D
G
T
V
L
G
V
H
L
L
G
D
G
A
P
E
I
I
Q
A
V
G
V
C
L
R
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
-