@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1435: (2016-03-24 )
MDLGKVITAMVTPIHPEKDKVCKKRIHHLVNHLIKNGSDGLVIAGTTGESPTLSHDEKIKLFRQVIETNDGRAKLIAGTGSNNTAETIAFTKEVATLGGMDAVLIVAPYYNKPNQDGLYAHFAAVAEASDLPVVIYNIPGRSVVNIEPETIIRLAKLPNIVGVKESSGNLDNISKIIAETSDDFQVYSGDDSLTLPILAVGGNGVISVASHIVGNEMQEMIQAFERGEVQKAAQIHRELLPLMNGLFSVPNPAPTKYLLNQQGISVGPVRLPLVDLNAEQGTKLQAILEGLSK
Atome Classification :
(48 SA)
.........10.......--.20........30........40........50........60........70........80.......---.90........100.......110.......120......-.130.......140.......150...-.-.-..160.......170.......180........190.......200.......210.......220.......230.......240--.......---.250.......260.-......270.......280.......290.-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
L
G
K
V
I
T
A
M
VTPIHP
E
K
--
D
K
V
C
K
K
R
I
H
H
L
V
N
H
L
IKNGSD
G
L
V
I
AGTTGESPTLS
H
D
E
K
I
K
L
F
R
Q
V
I
ETNDG
R
A
K
L
I
A
GTGSNNT
A
E
T
I
---
A
F
T
K
E
V
A
TLGG
M
D
A
V
L
I
VAPYYNKPNQD
G
L
Y
A
H
F
A
A
V
AEA-SDL
P
V
V
I
Y
NIPG
R
S
V
V
NI
E
P
E
T
I
I
R
L
A-K-L-P
N
I
V
G
V
KESSG
N
L
D
N
I
S
K
I
I
AET-SDD
F
Q
V
YSGDD
S
L
T
L
P
I
L
A
VGG
N
G
V
I
S
V
A
S
H
I
V
G
N
E
M
Q
E
M
I
Q
A
F
ERG
E
V
Q
K
A
A
Q
I
H
R
E
L
L
P
---
L
M
N
G
L
FS---VPNPAPT
K
Y
L
L
NQQG-ISVG
P
V
R
L
P
L
V
DLNAEQG
T
K
L
Q
A
I
L
E
G
LSK-
113
HHSearch
97.18
49%
-100
- C6 -
1XKY
2
?
A:
[12-300]
-
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
---
G
N
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
---
D
L
T
K
K
A
T
E
V
-
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
-
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
S
-
E
-
I
-
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
-
A
D
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
---
V
T
D
S
L
F
M
---
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
-
L
D
V
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
P
--
1
PsiBlast_PDB
96.83
49%
-96
- C6 -
1XKY
2
?
A:
[11-301]
I
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
--
N
-
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
---
D
L
T
K
K
-
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
-
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
S
-
E
-
I
-
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
-
A
D
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
---
V
T
D
S
L
F
M
---
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
-
L
D
V
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
P
R
-
21
PsiBlast_CBE
96.36
49%
-94
- C6 -
1XKY
2
?
D:
[11-301]
I
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
--
N
-
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
---
D
L
T
K
K
-
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
-
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
S
-
E
-
I
-
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
-
A
D
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
---
V
T
D
S
L
F
M
---
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
-
L
D
V
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
P
R
-
22
PsiBlast_CBE
95.92
49%
-93
- C6 -
1XKY
3
?
C:
[11-301]
I
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
--
N
-
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
---
D
L
T
K
K
-
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
-
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
S
-
E
-
I
-
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
-
A
D
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
---
V
T
D
S
L
F
M
---
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
-
L
D
V
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
P
R
-
23
PsiBlast_CBE
95.85
49%
-95
- C6 -
1XKY
3
?
B:
[11-301]
I
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
--
N
-
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
---
D
L
T
K
K
-
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
-
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
S
-
E
-
I
-
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
-
A
D
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
---
V
T
D
S
L
F
M
---
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
-
L
D
V
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
P
R
-
2
PsiBlast_PDB
94.71
49%
-93
- C6 -
1XL9
-
?
A:
[2-292]
I
D
F
G
T
I
A
T
A
M
V
T
P
F
D
I
N
G
--
N
-
I
D
F
A
K
T
T
K
L
V
N
Y
L
I
D
N
G
T
T
A
I
V
V
G
G
T
T
G
E
S
P
T
L
T
S
E
E
K
V
A
L
Y
R
H
V
V
S
V
V
D
K
R
V
P
V
I
A
G
T
G
S
N
N
T
H
A
S
I
---
D
L
T
K
K
-
A
T
E
V
G
V
D
A
V
M
L
V
A
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
E
S
-
T
P
L
P
V
M
L
Y
N
V
P
G
R
S
I
V
Q
I
S
V
D
T
V
V
R
L
S
-
E
-
I
-
E
N
I
V
A
I
K
D
A
G
G
D
V
L
T
M
T
E
I
I
E
K
T
-
A
D
D
F
A
V
Y
S
G
D
D
G
L
T
L
P
A
M
A
V
G
A
K
G
I
V
S
V
A
S
H
V
I
G
N
E
M
Q
E
M
I
A
A
F
Q
A
G
E
F
K
K
A
Q
K
L
H
Q
L
L
V
R
---
V
T
D
S
L
F
M
---
A
P
S
P
T
P
V
K
T
A
L
Q
M
V
G
-
L
D
V
G
S
V
R
L
P
L
L
P
L
T
E
E
E
R
V
T
L
Q
S
V
M
Q
S
I
P
R
-
3
PsiBlast_PDB
93.57
50%
-101
- C6 -
3VFL
7
?
A:
[10-279]
----
K
I
I
T
A
F
I
T
P
F
H
-
E
D
--
G
S
I
N
F
D
A
I
P
A
L
I
E
H
L
L
A
H
H
T
D
G
I
L
L
A
G
T
T
A
E
S
P
T
L
T
H
D
E
E
L
E
L
F
A
A
V
Q
K
V
V
N
G
R
V
P
L
I
A
G
V
G
T
N
D
T
R
D
S
I
---
E
F
V
K
E
V
A
E
F
G
G
F
A
A
G
L
A
I
V
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
D
A
-
S
D
L
P
I
I
I
Y
N
I
P
G
R
V
V
V
E
L
T
P
E
T
M
L
R
L
A
-
D
-
H
-
P
N
I
I
G
V
K
E
C
T
-
S
L
A
N
M
A
Y
L
I
E
H
K
-
P
E
E
F
L
I
Y
T
G
E
D
G
D
A
F
H
A
M
N
L
G
A
D
G
V
I
S
V
A
S
H
T
N
G
D
E
M
H
E
M
F
T
A
I
A
E
S
D
M
K
K
A
A
A
I
Q
R
K
F
I
P
---
K
V
N
A
L
F
S
---
Y
P
S
P
A
P
V
K
A
I
L
N
Y
M
G
-
F
E
A
G
P
T
R
L
P
L
V
--------------------
24
PsiBlast_CBE
92.91
50%
-100
- C6 -
3VFL
7
?
B:
[10-281]
----
K
I
I
T
A
F
I
T
P
F
H
-
E
D
--
G
S
I
N
F
D
A
I
P
A
L
I
E
H
L
L
A
H
H
T
D
G
I
L
L
A
G
T
T
A
E
S
P
T
L
T
H
D
E
E
L
E
L
F
A
A
V
Q
K
V
V
N
G
R
V
P
L
I
A
G
V
G
T
N
D
T
R
D
S
I
---
E
F
V
K
E
V
A
E
F
G
G
F
A
A
G
L
A
I
V
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
D
A
-
S
D
L
P
I
I
I
Y
N
I
P
G
R
V
V
V
E
L
T
P
E
T
M
L
R
L
A
-
D
-
H
-
P
N
I
I
G
V
K
E
C
T
-
S
L
A
N
M
A
Y
L
I
E
H
K
-
P
E
E
F
L
I
Y
T
G
E
D
G
D
A
F
H
A
M
N
L
G
A
D
G
V
I
S
V
A
S
H
T
N
G
D
E
M
H
E
M
F
T
A
I
A
E
S
D
M
K
K
A
A
A
I
Q
R
K
F
I
P
---
K
V
N
A
L
F
S
---
Y
P
S
P
A
P
V
K
A
I
L
N
Y
M
G
-
F
E
A
G
P
T
R
L
P
L
V
--------------------
5
PsiBlast_PDB
91.43
44%
-99
- C6 -
2YXG
-
DAPA_METJA
A:
[5-286]
-----
V
Y
P
A
I
I
T
P
F
--
K
N
--
K
E
V
D
F
D
G
L
E
E
N
I
N
F
L
I
E
N
G
V
S
G
I
V
A
V
G
T
T
G
E
S
P
T
L
S
H
E
E
H
K
K
V
I
E
K
V
V
D
V
V
N
G
R
V
Q
V
I
A
G
A
G
S
N
C
T
E
E
A
I
E
L
S
V
F
A
E
D
V
----
G
A
D
A
V
L
S
I
T
P
Y
Y
N
K
P
T
Q
E
G
L
R
K
H
F
G
K
V
A
E
S
-
I
N
L
P
I
V
L
Y
N
V
P
S
R
T
A
V
N
L
E
P
K
T
V
K
L
L
A
-
E
E
Y
-
S
N
I
S
A
V
K
E
A
N
P
N
L
S
Q
V
S
E
L
I
H
D
A
-
K
--
I
T
V
L
S
G
N
D
E
L
T
L
P
I
I
A
L
G
G
K
G
V
I
S
V
V
A
N
I
V
P
K
E
F
V
E
M
V
N
Y
A
L
E
G
D
F
E
K
A
R
E
I
H
Y
K
L
F
P
---
L
M
K
A
M
F
I
---
E
T
N
P
I
P
V
K
T
A
L
N
M
M
G
-
R
P
A
G
E
L
R
L
P
L
C
E
M
S
E
E
H
K
K
I
L
E
N
V
L
K
D
L
---
130
HHSearch
90.30
44%
-94
- C6 -
2YXG
-
DAPA_METJA
A:
[1-287]
-
M
F
K
G
V
Y
P
A
I
I
T
P
F
K
-
N
---
K
E
V
D
F
D
G
L
E
E
N
I
N
F
L
I
E
N
G
V
S
G
I
V
A
V
G
T
T
G
E
S
P
T
L
S
H
E
E
H
K
K
V
I
E
K
V
V
D
V
V
N
G
R
V
Q
V
I
A
G
A
G
S
N
C
T
E
E
A
I
---
E
L
S
V
F
A
E
D
V
-
G
A
D
A
V
L
S
I
T
P
Y
Y
N
K
P
T
Q
E
G
L
R
K
H
F
G
K
V
A
E
S
-
I
N
L
P
I
V
L
Y
N
V
P
S
R
T
A
V
N
L
E
P
K
T
V
K
L
L
A
E
E
-
Y
-
S
N
I
S
A
V
K
E
A
N
P
N
L
S
Q
V
S
E
L
I
H
---
D
A
K
I
T
V
L
S
G
N
D
E
L
T
L
P
I
I
A
L
G
G
K
G
V
I
S
V
V
A
N
I
V
P
K
E
F
V
E
M
V
N
Y
A
L
E
G
D
F
E
K
A
R
E
I
H
Y
K
L
F
P
---
L
M
K
A
M
F
I
---
E
T
N
P
I
P
V
K
T
A
L
N
M
M
G
-
R
P
A
G
E
L
R
L
P
L
C
E
M
S
E
E
H
K
K
I
L
E
N
V
L
K
D
L
G
--
4
PsiBlast_PDB
90.28
44%
-83
- C6 -
1XXX
3
DAPA_MYCTU
A:
[15-300]
--
L
G
T
L
L
T
A
M
V
T
P
F
S
G
D
G
SL
D
T
A
T
A
A
R
---
L
A
N
H
L
V
D
Q
G
C
D
G
L
V
V
S
G
T
T
G
E
S
P
T
T
T
D
G
E
K
I
E
L
L
R
A
V
L
E
A
V
G
D
R
A
R
V
I
A
G
A
G
T
Y
D
T
A
H
S
I
---
R
L
A
K
A
C
A
A
E
G
A
-
H
G
L
L
V
V
T
P
Y
Y
S
K
P
P
Q
R
G
L
Q
A
H
F
T
A
V
A
D
A
-
T
E
L
P
M
L
L
Y
D
I
P
G
R
S
A
V
P
I
E
P
D
T
I
R
A
L
A
-
S
-
H
-
P
N
I
V
G
V
K
D
A
K
A
D
L
H
S
G
A
Q
I
M
A
D
T
-
G
--
L
A
Y
Y
S
G
D
D
A
L
N
L
P
W
L
A
M
G
A
T
G
F
I
S
V
I
A
H
L
A
A
G
Q
L
R
E
L
L
S
A
F
G
S
G
D
I
A
T
A
R
K
I
N
I
A
V
A
P
---
L
C
N
A
M
S
R
---
L
G
G
V
T
L
S
K
A
G
L
R
L
Q
G
-
I
D
V
G
D
P
R
L
P
Q
V
A
A
T
P
E
Q
I
D
A
L
A
A
D
M
R
A
A
S
--
27
PsiBlast_CBE
90.25
44%
-86
- C6 -
1XXX
2
DAPA_MYCTU
F:
[15-300]
--
L
G
T
L
L
T
A
M
V
T
P
F
S
G
D
G
SL
D
T
A
T
A
A
R
---
L
A
N
H
L
V
D
Q
G
C
D
G
L
V
V
S
G
T
T
G
E
S
P
T
T
T
D
G
E
K
I
E
L
L
R
A
V
L
E
A
V
G
D
R
A
R
V
I
A
G
A
G
T
Y
D
T
A
H
S
I
---
R
L
A
K
A
C
A
A
E
G
A
-
H
G
L
L
V
V
T
P
Y
Y
S
K
P
P
Q
R
G
L
Q
A
H
F
T
A
V
A
D
A
-
T
E
L
P
M
L
L
Y
D
I
P
G
R
S
A
V
P
I
E
P
D
T
I
R
A
L
A
-
S
-
H
-
P
N
I
V
G
V
K
D
A
K
A
D
L
H
S
G
A
Q
I
M
A
D
T
-
G
--
L
A
Y
Y
S
G
D
D
A
L
N
L
P
W
L
A
M
G
A
T
G
F
I
S
V
I
A
H
L
A
A
G
Q
L
R
E
L
L
S
A
F
G
S
G
D
I
A
T
A
R
K
I
N
I
A
V
A
P
---
L
C
N
A
M
S
R
---
L
G
G
V
T
L
S
K
A
G
L
R
L
Q
G
-
I
D
V
G
D
P
R
L
P
Q
V
A
A
T
P
E
Q
I
D
A
L
A
A
D
M
R
A
A
S
--
31
PsiBlast_CBE
89.96
44%
-84
- C6 -
1XXX
3
DAPA_MYCTU
B:
[15-300]
--
L
G
T
L
L
T
A
M
V
T
P
F
S
G
D
G
SL
D
T
A
T
A
A
R
---
L
A
N
H
L
V
D
Q
G
C
D
G
L
V
V
S
G
T
T
G
E
S
P
T
T
T
D
G
E
K
I
E
L
L
R
A
V
L
E
A
V
G
D
R
A
R
V
I
A
G
A
G
T
Y
D
T
A
H
S
I
---
R
L
A
K
A
C
A
A
E
G
A
-
H
G
L
L
V
V
T
P
Y
Y
S
K
P
P
Q
R
G
L
Q
A
H
F
T
A
V
A
D
A
-
T
E
L
P
M
L
L
Y
D
I
P
G
R
S
A
V
P
I
E
P
D
T
I
R
A
L
A
-
S
-
H
-
P
N
I
V
G
V
K
D
A
K
A
D
L
H
S
G
A
Q
I
M
A
D
T
-
G
--
L
A
Y
Y
S
G
D
D
A
L
N
L
P
W
L
A
M
G
A
T
G
F
I
S
V
I
A
H
L
A
A
G
Q
L
R
E
L
L
S
A
F
G
S
G
D
I
A
T
A
R
K
I
N
I
A
V
A
P
---
L
C
N
A
M
S
R
---
L
G
G
V
T
L
S
K
A
G
L
R
L
Q
G
-
I
D
V
G
D
P
R
L
P
Q
V
A
A
T
P
E
Q
I
D
A
L
A
A
D
M
R
A
A
S
--
29
PsiBlast_CBE
89.58
44%
-86
- C6 -
1XXX
2
DAPA_MYCTU
D:
[15-300]
--
L
G
T
L
L
T
A
M
V
T
P
F
S
G
D
G
SL
D
T
A
T
A
A
R
---
L
A
N
H
L
V
D
Q
G
C
D
G
L
V
V
S
G
T
T
G
E
S
P
T
T
T
D
G
E
K
I
E
L
L
R
A
V
L
E
A
V
G
D
R
A
R
V
I
A
G
A
G
T
Y
D
T
A
H
S
I
---
R
L
A
K
A
C
A
A
E
G
A
-
H
G
L
L
V
V
T
P
Y
Y
S
K
P
P
Q
R
G
L
Q
A
H
F
T
A
V
A
D
A
-
T
E
L
P
M
L
L
Y
D
I
P
G
R
S
A
V
P
I
E
P
D
T
I
R
A
L
A
-
S
-
H
-
P
N
I
V
G
V
K
D
A
K
A
D
L
H
S
G
A
Q
I
M
A
D
T
-
G
--
L
A
Y
Y
S
G
D
D
A
L
N
L
P
W
L
A
M
G
A
T
G
F
I
S
V
I
A
H
L
A
A
G
Q
L
R
E
L
L
S
A
F
G
S
G
D
I
A
T
A
R
K
I
N
I
A
V
A
P
---
L
C
N
A
M
S
R
---
L
G
G
V
T
L
S
K
A
G
L
R
L
Q
G
-
I
D
V
G
D
P
R
L
P
Q
V
A
A
T
P
E
Q
I
D
A
L
A
A
D
M
R
A
A
S
--
28
PsiBlast_CBE
89.46
44%
-84
- C6 -
1XXX
2
DAPA_MYCTU
E:
[15-300]
--
L
G
T
L
L
T
A
M
V
T
P
F
S
G
D
G
SL
D
T
A
T
A
A
R
---
L
A
N
H
L
V
D
Q
G
C
D
G
L
V
V
S
G
T
T
G
E
S
P
T
T
T
D
G
E
K
I
E
L
L
R
A
V
L
E
A
V
G
D
R
A
R
V
I
A
G
A
G
T
Y
D
T
A
H
S
I
---
R
L
A
K
A
C
A
A
E
G
A
-
H
G
L
L
V
V
T
P
Y
Y
S
K
P
P
Q
R
G
L
Q
A
H
F
T
A
V
A
D
A
-
T
E
L
P
M
L
L
Y
D
I
P
G
R
S
A
V
P
I
E
P
D
T
I
R
A
L
A
-
S
-
H
-
P
N
I
V
G
V
K
D
A
K
A
D
L
H
S
G
A
Q
I
M
A
D
T
-
G
--
L
A
Y
Y
S
G
D
D
A
L
N
L
P
W
L
A
M
G
A
T
G
F
I
S
V
I
A
H
L
A
A
G
Q
L
R
E
L
L
S
A
F
G
S
G
D
I
A
T
A
R
K
I
N
I
A
V
A
P
---
L
C
N
A
M
S
R
---
L
G
G
V
T
L
S
K
A
G
L
R
L
Q
G
-
I
D
V
G
D
P
R
L
P
Q
V
A
A
T
P
E
Q
I
D
A
L
A
A
D
M
R
A
A
S
--
26
PsiBlast_CBE
89.44
44%
-83
- C6 -
1XXX
2
DAPA_MYCTU
G:
[15-300]
--
L
G
T
L
L
T
A
M
V
T
P
F
S
G
D
G
SL
D
T
A
T
A
A
R
---
L
A
N
H
L
V
D
Q
G
C
D
G
L
V
V
S
G
T
T
G
E
S
P
T
T
T
D
G
E
K
I
E
L
L
R
A
V
L
E
A
V
G
D
R
A
R
V
I
A
G
A
G
T
Y
D
T
A
H
S
I
---
R
L
A
K
A
C
A
A
E
G
A
-
H
G
L
L
V
V
T
P
Y
Y
S
K
P
P
Q
R
G
L
Q
A
H
F
T
A
V
A
D
A
-
T
E
L
P
M
L
L
Y
D
I
P
G
R
S
A
V
P
I
E
P
D
T
I
R
A
L
A
-
S
-
H
-
P
N
I
V
G
V
K
D
A
K
A
D
L
H
S
G
A
Q
I
M
A
D
T
-
G
--
L
A
Y
Y
S
G
D
D
A
L
N
L
P
W
L
A
M
G
A
T
G
F
I
S
V
I
A
H
L
A
A
G
Q
L
R
E
L
L
S
A
F
G
S
G
D
I
A
T
A
R
K
I
N
I
A
V
A
P
---
L
C
N
A
M
S
R
---
L
G
G
V
T
L
S
K
A
G
L
R
L
Q
G
-
I
D
V
G
D
P
R
L
P
Q
V
A
A
T
P
E
Q
I
D
A
L
A
A
D
M
R
A
A
S
--
30
PsiBlast_CBE
89.43
44%
-84
- C6 -
1XXX
2
DAPA_MYCTU
C:
[15-300]
--
L
G
T
L
L
T
A
M
V
T
P
F
S
G
D
G
SL
D
T
A
T
A
A
R
---
L
A
N
H
L
V
D
Q
G
C
D
G
L
V
V
S
G
T
T
G
E
S
P
T
T
T
D
G
E
K
I
E
L
L
R
A
V
L
E
A
V
G
D
R
A
R
V
I
A
G
A
G
T
Y
D
T
A
H
S
I
---
R
L
A
K
A
C
A
A
E
G
A
-
H
G
L
L
V
V
T
P
Y
Y
S
K
P
P
Q
R
G
L
Q
A
H
F
T
A
V
A
D
A
-
T
E
L
P
M
L
L
Y
D
I
P
G
R
S
A
V
P
I
E
P
D
T
I
R
A
L
A
-
S
-
H
-
P
N
I
V
G
V
K
D
A
K
A
D
L
H
S
G
A
Q
I
M
A
D
T
-
G
--
L
A
Y
Y
S
G
D
D
A
L
N
L
P
W
L
A
M
G
A
T
G
F
I
S
V
I
A
H
L
A
A
G
Q
L
R
E
L
L
S
A
F
G
S
G
D
I
A
T
A
R
K
I
N
I
A
V
A
P
---
L
C
N
A
M
S
R
---
L
G
G
V
T
L
S
K
A
G
L
R
L
Q
G
-
I
D
V
G
D
P
R
L
P
Q
V
A
A
T
P
E
Q
I
D
A
L
A
A
D
M
R
A
A
S
--
122
HHSearch
89.09
41%
-92
- C6 -
2RFG
2
?
A:
[1-288]
-
M
F
R
G
S
L
I
A
M
I
T
P
F
I
-
N
---
G
Q
V
D
E
K
A
L
A
G
L
V
D
W
Q
I
K
H
G
A
H
G
L
V
P
V
G
T
T
G
E
S
P
T
L
T
E
E
E
H
K
R
V
V
A
L
V
A
E
Q
A
Q
G
R
V
P
V
I
A
G
A
G
S
N
N
P
V
E
A
V
---
R
Y
A
Q
H
A
Q
Q
A
-
G
A
D
A
V
L
C
V
A
G
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
M
V
H
D
A
-
I
D
I
P
I
I
V
Y
N
I
P
P
R
A
V
V
D
I
K
P
E
T
M
A
R
L
A
-
A
-
L
-
P
R
I
V
G
V
K
D
A
T
T
D
L
A
R
I
S
R
E
R
M
L
I
-
N
K
P
F
S
F
L
S
G
D
D
M
T
A
I
A
Y
N
A
S
G
G
Q
G
C
I
S
V
S
A
N
I
A
P
A
L
Y
G
Q
M
Q
T
A
T
L
Q
G
D
F
R
E
A
L
R
I
H
D
L
L
A
P
---
L
H
E
A
L
F
R
---
E
P
S
P
A
G
A
K
Y
A
A
S
L
L
G
-
L
C
N
E
E
C
R
L
P
I
V
P
L
S
E
Q
T
K
S
D
I
K
N
I
I
N
E
L
Y
--
127
HHSearch
88.80
41%
-94
- C6 -
2EHH
1
DAPA_AQUAE
A:
[1-289]
-
M
F
Q
G
S
I
V
A
L
I
T
P
F
K
-
E
---
G
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
A
A
G
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
---
H
L
T
A
H
A
K
E
V
-
G
A
D
G
A
L
V
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
-
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
M
F
K
L
A
S
E
-
C
-
E
N
I
V
A
S
K
E
S
T
P
N
M
D
R
I
S
E
I
V
K
R
L
-
G
E
S
F
S
V
L
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
E
L
I
R
A
A
L
E
G
D
F
R
R
A
R
E
I
H
Y
Y
L
H
D
---
L
F
K
V
L
F
I
---
E
T
N
P
I
P
V
K
T
A
C
W
M
L
G
-
M
C
E
K
E
F
R
L
P
L
T
E
M
S
P
E
N
E
N
K
L
R
E
V
L
K
K
Y
N
--
102
Fugue
88.58
38%
-92
- C6 -
1DHP
1
DAPA_ECOLI
A:
[1-292]
-
M
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
---
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
---
S
L
T
Q
R
F
N
D
S
G
-
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
-
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
V
---
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
118
HHSearch
88.04
40%
-87
- C6 -
3FLU
13
DAPA_NEIMB
A:
[6-295]
T
M
L
Q
G
S
L
V
A
L
I
T
P
M
N
Q
D
---
G
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
K
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
---
A
L
S
Q
A
A
E
K
A
-
G
A
D
Y
T
L
S
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
-
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
I
L
R
L
A
-
E
-
I
-
P
N
I
V
G
V
K
E
A
S
G
N
I
G
S
N
I
E
L
I
N
R
A
-
P
E
G
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
D
M
C
R
A
A
L
Q
G
D
I
A
L
A
R
E
L
N
D
R
L
I
P
---
I
Y
D
T
M
F
C
---
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
-
R
C
E
P
H
V
R
L
P
L
V
P
L
T
E
N
G
Q
A
K
V
R
A
A
L
K
A
S
G
--
36
PsiBlast_CBE
87.33
40%
-93
- C6 -
3I7S
13
DAPA_ECOLI
B:
[6-287]
------
I
V
A
I
V
T
P
M
D
-
E
K
--
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
---
S
L
T
Q
R
F
N
D
-
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
-
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
V
---
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
-----
12
PsiBlast_PDB
87.20
40%
-94
- C6 -
3I7S
10
DAPA_ECOLI
A:
[6-287]
------
I
V
A
I
V
T
P
M
D
-
E
K
--
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
---
S
L
T
Q
R
F
N
D
-
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
-
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
V
---
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
-----
11
PsiBlast_PDB
86.14
40%
-91
- C6 -
3I7R
10
DAPA_ECOLI
A:
[6-287]
------
I
V
A
I
V
T
P
M
D
-
E
K
--
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
---
S
L
T
Q
R
F
N
D
-
S
G
I
V
G
C
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
-
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
-
V
-
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
I
K
E
L
V
-
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
L
M
P
---
L
H
N
K
L
F
V
---
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
L
R
L
P
M
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
-----
62
PsiBlast_CBE
84.30
40%
-91
- C6 -
3S8H
1
DAPA_PSEAE
B:
[6-274]
------
M
V
A
L
V
T
P
F
D
-
A
Q
--
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
---
A
L
T
-
E
A
A
K
S
G
G
A
D
A
C
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
-
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
-
V
-
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
E
R
V
-
G
K
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
L
M
P
---
L
H
K
A
L
F
I
---
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
-
L
I
P
E
G
I
R
L
P
L
T
W
L
S
-----------------
120
HHSearch
84.07
37%
-89
- C6 -
3TAK
3
?
A:
[1-289]
-
T
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
---
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
---
E
L
T
K
A
A
K
D
L
-
G
A
D
A
A
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
-
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
-
I
-
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
L
I
D
A
L
-
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
I
A
N
---
L
H
N
I
L
F
C
---
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
-
L
I
D
T
G
I
R
L
P
L
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
--
71
PsiBlast_CBE
83.84
40%
-97
- C6 -
4ICN
6
?
A:
[12-283]
------
I
V
A
L
I
T
P
L
N
S
D
G
---
T