@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1473: (2016-03-25 )
MSKIIGIDLGTTNSAVAVLEGGEAKIIPNPEGARTTPSVVGFKNGERQVGEVAKRAAITNPNTISSIKRHMGTNYKETIEGKDYSPQEISAIILQYLKSYAEDYLGETVDKAVITVPAYFNDAQRQATKDAGKIAGLEVERIINEPTAAALAYGMDKTETDQTILVFDLGGGTFDVSILELGDGVFEVHSTAGDNELGGDDFDKKIIDYLVAEFKKDNGIDLSQDKMALQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLEVTLTRAKFDELTHDLVERTIAPTRQALKDANLSASDIDQVILVGGSTRIPAVQETIKKELGKEPHKGVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVMTTLIERNTTIPTSKSQTFSTAADNQPAVDIHVLQGERPMAKDNKTLGRFQLADIPPAPRGIPQIEVSFDIDKNGIVTVRAKDLGTGKEQNIVIKSSSGLTDEEIEKMVQDAEANAEEDKKNKENAELRNNADQLVFTVDKTLKELEGKVEEEEVKKAEAARDELQEALKGEDFDAIKEKTESLNEIVQNLSVKLYEQAAAEQQAAGGAEGQEAPQNDDVVDAEFEEVNDDDKENK
Atome Classification :
(90 SA)
...--......10........20........30........40.-.--......50........60-.-.......70.....-..---------------------------.---------------------------80---..---------------------------......90........100.......110.......120.......130.......140.......150....--.-.------.160........170.......180---.......--.190.......200.......210.......220.......230.......240....-...250.......260.......270.......280.-......290.......300.......310.......320.....-.-.330.......340.......350...----....360.......370...----....380.......390.......400......-.410.......420.......430.....-..440.......450.......----460.......470.-...-...480.......490.......500.......510.......520-.......530.......540.......550--.........560.......570.......580.......590.......600.......610.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
K
--
I
I
G
I
D
LGTTN
S
A
V
A
V
L
EGG
E
A
K
I
I
PNPEGARTTP
S
V
VGF-K--NG
E
R
Q
V
G
E
V
A
K
R
AAITNP-
N
-
T
I
S
S
I
K
R
H
MGT
N
Y
K
-
E
T---------------------------I---------------------------EG---KD---------------------------Y
S
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
T
VD
K
A
V
I
T
VPAYF
N
D
A
Q
R
Q
A
T
KDAGKIAGL
E
V
E
R
I
INEP
T
A
A
A
L
AYGMD--K-T------ET-D
Q
T
I
L
V
F
DLGG
G
T
F
D
V
S
I
L
EL----GD
G
V
F
E
V
--HSTAGDNELGG
D
D
F
D
K
K
I
I
D
Y
L
V
A
E
FKKDNGIDL
S
Q
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
D
LSGV-TST
Q
I
S
L
P
F
I
TAGEAG
P
L
H
L
E
V
T
L
T
R
A
K
F
D
E
L
T
H
D
L
V
-
E
R
T
I
A
P
T
R
Q
A
L
K
DANL
S
A
S
DI
D
Q
V
I
L
VGGSTRI
P
A
V
Q
E
T
I
K
K
E
L-G-KEPHKGV
N
P
D
E
V
V
A
MGAAIQG
G
V
I
TGD----V
K
D
V
V
L
L
DVT
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
ERNTTIPTSKSQTFSTAADNQP
A
V
D
I
-
H
V
LQGERPMAKDNKTLG
R
F
QLADIPPAPR-GI
P
Q
I
E
V
S
F
D
IDKN
G
I
V
T
V
R
A
K----DLGTGKEQ
N
I
V
I
KS-SSG-L
T
D
E
E
I
E
K
M
V
Q
D
AEANAEEDKKNKEN
A
E
LRNNA
D
Q
L
V
F
T
V
D
K
T
L
K
E
-
L
EGKV
E
E
E
E
V
K
K
A
E
A
A
R
D
E
L
Q
E
A
LKGE
D
----
F
D
A
I
K
E
K
T
E
S
L
N
E
I
V
Q
N
L
S
V
K
L
Y
E
Q
A
A
A
E
Q
QAAGGAEGQEAPQNDDVVD
A
E
F
E
EVNDDDKENK
6
PsiBlast_PDB
91.82
56%
-70
- C2 -
4B9Q
1
DNAK_ECOLI
A:
[3-598]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
C
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
-
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
E
---
V
---------------------------
K
G
---
Q
K
---------------------------
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
--
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------------
22
PsiBlast_CBE
91.40
56%
-66
- C2 -
4JN4
12
DNAK_ECOLI
B:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
-
D
E
EVQRDVSIMPFKIIAADNGDAWVE---
V
---------------------------
K
G
---
Q
K
---------------------------
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
K
T
F
E
V
--
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------------
3
PsiBlast_PDB
91.20
57%
-71
- C3 -
2KHO
-
DNAK_ECOLI
A:
[4-598]
-----
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
-
D
E
E
V
Q
R
D
V
S
IMP
F
K
I
I
A
A
DNG
D
A
W
V
E
---
V
---------------------------
K
G
---
Q
K
---------------------------
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
EVD
G
E
K
T
F
E
V
--
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
D
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------------
21
PsiBlast_CBE
91.10
56%
-63
- C2 -
4JNE
11
DNAK_ECOLI
B:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
-
D
E
EVQRDVSIMPFKIIAADNGDAWVE---
V
---------------------------
K
G
---
Q
K
---------------------------
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
K
T
F
E
V
--
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------------
4
PsiBlast_PDB
91.01
56%
-66
- C2 -
4JN4
12
DNAK_ECOLI
A:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
-
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
E
---
V
---------------------------
K
G
---
Q
K
---------------------------
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
--
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------------
112
HHSearch
90.91
83%
-69
- C2 -
2V7Y
2
DNAK_GEOKA
A:
[1-504]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
--
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
-
T
I
I
S
I
K
R
H
M
G
T
D
Y
K
-
V
E
---------------------------
I
---------------------------
E
G
---
K
Q
---------------------------
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-
E
-------
E
-
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
--
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
-
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
----
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
-----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.89
83%
-70
- C3 -
4ANI
-
DNAK_GEOKA
C:
[1-509]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
--
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
-
T
I
I
S
I
K
R
H
M
G
T
D
Y
K
-
V
E
---------------------------
I
---------------------------
E
G
---
K
Q
---------------------------
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-
E
------
E
--
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
--
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
-
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
----
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
D
------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.81
83%
-69
- C2 -
2V7Y
2
DNAK_GEOKA
A:
[1-504]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
--
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
-
T
I
I
S
I
K
R
H
M
G
T
D
Y
K
-
V
E
---------------------------
I
---------------------------
E
G
---
K
Q
---------------------------
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-
E
------
E
--
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
--
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
-
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
----
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
-----------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
90.20
56%
-64
- C2 -
4JNE
12
DNAK_ECOLI
A:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
-
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
-
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
E
---
V
---------------------------
K
G
---
Q
K
---------------------------
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
--
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
---------------------------------------------
8
PsiBlast_PDB
84.18
49%
-64
- C2 -
1YUW
-
HSP7C_BOVIN
A:
[1-553]
M
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
----
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
-
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
----
D
K
S
T
G
K
E
N
K
I
T
I
T
N
-
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
--------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
84.01
49%
-69
- C2 -
3C7N
9
HSP7C_BOVIN
B:
[3-547]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
MKHWP
F
M
V
V
N
DAG
R
P
K
V
Q
V
EYKG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-----
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
----
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
-
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
----
D
K
S
T
G
K
E
N
K
I
T
I
T
N
-
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
--------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
74.53
46%
-77
- C2 -
3CQX
1
HSP7C_MOUSE
B:
[10-386]
---P-
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
74.39
46%
-79
- C2 -
3LDQ
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Fugue
74.29
61%
-77
- C2 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
-
T
QD-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
-
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
-
D
E
---------------------------
E
VQRDVSIMPFKIIAADNGDAWVEVKG------
Q
K
---------------------------
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---------
T
G
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
----
D
E
K
T
F
E
V
LA--
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
-A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N-
R
S
I
E
L
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G--
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
74.26
46%
-78
- C2 -
3FZM
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
EYKG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
74.20
49%
-71
- C2 -
3GL1
6
HSP75_YEAST
A:
[13-387]
------
I
G
I
D
L
G
T
T
Y
S
C
V
A
T
Y
E
S
-
S
V
E
I
I
A
N
E
Q
G
N
R
V
T
P
S
F
V
A
F
-
T
--
P
E
E
R
L
I
G
D
A
A
K
N
Q
A
A
L
N
P
R
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
E
S
---------------------------
V
Q
K
D
M
K
T
WP
F
K
V
I
D
V
DG
N
P
V
I
E
V
Q
Y
LE-
E
T
---
K
T
---------------------------
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
A
K
I
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
A
I
S
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
AG
K
-
S
------
E
K
-
E
R
H
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
H
I
----
A
G
G
V
Y
T
V
--
K
S
T
S
G
N
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
H
F
K
A
E
F
K
K
K
T
G
L
D
I
S
D
D
A
R
A
L
R
R
L
R
T
A
A
E
R
A
K
R
T
L
S
S
V
-
T
Q
T
T
V
E
V
D
S
L
F
D
G
E
----
D
F
E
S
S
L
T
R
A
R
F
E
D
L
N
A
A
L
F
-
K
S
T
L
E
P
V
E
Q
V
L
K
D
A
K
I
S
K
S
Q
I
D
E
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
S
D
F
F
D
G
-
K
Q
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
G
A
I
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
73.95
47%
-75
- C2 -
1BA1
4
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
K
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
73.95
47%
-75
- C2 -
1HPM
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
73.87
49%
-70
- C2 -
3GL1
7
HSP75_YEAST
B:
[13-387]
------
I
G
I
D
L
G
T
T
Y
S
C
V
A
T
Y
E
S
-
S
V
E
I
I
A
N
E
Q
G
N
R
V
T
P
S
F
V
A
F
-
T
--
P
E
E
R
L
I
G
D
A
A
K
N
Q
A
A
L
N
P
R
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
E
S
---------------------------
V
Q
K
D
M
K
T
WP
F
K
V
I
D
V
DG
N
P
V
I
E
V
Q
Y
LE-
E
T
---
K
T
---------------------------
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
A
K
I
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
A
I
S
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
AG
K
-
S
------
E
K
-
E
R
H
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
H
I
----
A
G
G
V
Y
T
V
--
K
S
T
S
G
N
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
H
F
K
A
E
F
K
K
K
T
G
L
D
I
S
D
D
A
R
A
L
R
R
L
R
T
A
A
E
R
A
K
R
T
L
S
S
V
-
T
Q
T
T
V
E
V
D
S
L
F
D
G
E
----
D
F
E
S
S
L
T
R
A
R
F
E
D
L
N
A
A
L
F
-
K
S
T
L
E
P
V
E
Q
V
L
K
D
A
K
I
S
K
S
Q
I
D
E
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
S
D
F
F
D
G
-
K
Q
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
G
A
I
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
73.81
27%
-51
- C2 -
3D2F
4
?
A:
[2-634]
-
S
T
--
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
A
R
N
R
G
I
D
I
V
V
N
E
V
S
N
R
S
T
P
S
V
V
G
F
-
G
--
P
K
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
N
-
T
V
A
N
L
K
R
I
I
G
L
D
Y
H
-
H
P
D
F
E
Q
E
S
K
H
FT
S
K
L
V
E
L
DDK
K
T
G
A
E
---
V
R
F
AG-----------------------
E
K
---
H
V
---------------------------
F
S
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
--
K
-
T
DLPEGE
E
K
-
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
----
K
K
G
Q
L
K
V
--
L
G
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
T
K
Y
K
I
D
I
R
E
N
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
S
A
N
-
T
N
A
P
F
S
V
E
S
V
M
N
D
----
V
D
V
S
S
Q
L
S
R
E
E
L
E
E
L
V
K
P
L
L
-
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
-
G
-
K
P
L
S
T
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
P
T
LR--
V
R
P
F
K
F
E
D
I
H
P
Y
S
V
S
Y
S
W
D
K
QVED
E
D
H
M
E
V
F
P
A
G
S
S
F
P
S
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
T
D
I
T
Q
L
P
---
P
N
T
P
E
Q
I
A
N
W
E
I
T
G
V
Q
L
P
E
G
Q
D
S
V
P
V
K
L
K
L
R
C
D
P
S
G
L
H
T
I
E
E
A
Y
T
I
E
D
T
K
T
V
K
K
D
D
L
T
I
V
A
H
T
F
G
-
L
D
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
E
E
Y
A
P
F
A
S
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
D
E
G
FDSI
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
-------------------------------
74
PsiBlast_CBE
73.73
46%
-76
- C2 -
3FZH
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
MKHWP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
73.69
46%
-74
- C2 -
1ATS
2
HSP7C_BOVIN
A:
[2-383]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K-
K
-
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
E
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
73.62
47%
-75
- C2 -
1NGI
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
73.60
46%
-73
- C2 -
1NGF
1
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K-
K
-
V
------
G
A
-
E
R
N
V
L
I
F
N
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
73.51
46%
-76
- C2 -
1KAZ
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
E
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
73.41
46%
-73
- C2 -
2QWQ
5
HSP7C_BOVIN
A:
[4-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
73.33
46%
-74
- C2 -
1BUP
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
S
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
73.32
46%
-74
- C2 -
1NGE
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
MKHWP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K-
K
-
V
------
G
A
-
E
R
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
73.24
46%
-74
- C2 -
1NGB
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
Q
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
73.16
47%
-74
- C2 -
3A8Y
1
HS71A_HUMAN
A:
[11-387]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
G
-
D
P
---------------------------
V
V
Q
S
D
MKHWP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
E
T
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
T
G-----
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
73.16
46%
-72
- C2 -
2QWR
4
HSP7C_BOVIN
A:
[4-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
73.15
46%
-73
- C2 -
2QWN
5
HSP7C_BOVIN
A:
[3-385]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
73.14
46%
-76
- C2 -
1KAY
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
A
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
73.13
46%
-71
- C2 -
1QQM
5
HSP7C_BOVIN
A:
[4-378]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
A
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
A
V
------
G
A
-
E
R
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
A
H
A
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
73.06
46%
-75
- C2 -
2BUP
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
G
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
73.03
46%
-72
- C2 -
1QQO
4
HSP7C_BOVIN
A:
[4-378]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
D
--
K
A
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
73.03
46%
-78
- C2 -
3FZK
3
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
73.03
46%
-75
- C2 -
3M3Z
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
MKHWP
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
73.00
46%
-75
- C2 -
1NGH
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
N
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
72.91
46%
-71
- C2 -
1ATR
3
HSP7C_BOVIN
A:
[2-383]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K-
K
-
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
V
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
72.91
46%
-72
- C2 -
4H5T
3
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
72.87
46%
-74
- C2 -
1NGG
1
HSP7C_BOVIN
A:
[3-381]
--
K
G
P
A
V
G
I
S
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
72.86
47%
-72
- C2 -
3HSC
5
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
72.78
46%
-77
- C2 -
3FZF
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
72.72
47%
-73
- C2 -
1HJO
2
HS71A_HUMAN
A:
[5-380]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
G
-
D
P
---------------------------
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
E
T
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
T
G-----
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
72.71
46%
-72
- C2 -
2QWL
4
HSP7C_BOVIN
B:
[4-384]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
VQSDMKHWPFMVVNDAGRPKVQVEYKG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
72.70
54%
-68
* C2 *
3QFU
3
GRP78_YEAST
A:
[18-393]
-
G
T
--
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
--
D
D
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
-
T
I
F
D
I
K
R
L
I
G
L
K
Y
N
-
D
R
S
V
Q
K
D
I
K
H
LP
F
N
V
V
N
K
DG
K
P
A
V
E
V
S
V
K
G
---------------------------
E
K
---
K
V
---------------------------
F
T
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
-
S
------
D
K
-
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
----
E
N
G
V
F
E
V
--
Q
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
-
M
S
T
R
I
E
I
D
S
F
V
D
G
----
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
-
D
G
K
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
72.63
46%
-72
- C2 -
2QWM
5
HSP7C_BOVIN
B:
[4-384]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
VQSDMKHWPFMVVNDAGRPKVQVEYKG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.59
46%
-71
- C2 -
2QWM
5
HSP7C_BOVIN
A:
[4-384]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
72.57
47%
-71
- C2 -
1NGJ
2
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
72.55
46%
-74
- C2 -
1NGA
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
72.48
46%
-75
- C2 -
2QWP
7
HSP7C_BOVIN
A:
[4-389]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
72.47
47%
-69
- C2 -
3ATV
3
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
G
-
D
P
---------------------------
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
E
T
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
T
G-----
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
72.36
46%
-74
- C2 -
1KAX
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
M
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
72.33
46%
-73
- C2 -
1NGC
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K-
K
-
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
72.32
46%
-75
- C2 -
1NGD
3
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K-
K
-
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
N
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
72.32
46%
-71
- C2 -
2QWO
7
HSP7C_BOVIN
A:
[4-390]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
72.26
46%
-74
- C2 -
3FZL
2
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
72.25
47%
-71
- C2 -
4J8F
14
F10A1_RAT (first)
A:
[14-389]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
G
-
D
P
---------------------------
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
E
T
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
T
G-----
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
72.18
51%
-71
- C2 -
3I33
3
HSP72_HUMAN
A:
[23-402]
-
M
P
--
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
I
F
D
A
K
R
L
I
G
R
K
F
E
-
D
A
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
Q
V
E
Y
K
G
---------------------------
E
T
---
K
T
---------------------------
F
F
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
-
K
GCA---
G
G
-
E
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.13
46%
-71
- C2 -
2QWL
4
HSP7C_BOVIN
A:
[4-384]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
72.02
46%
-69
- C2 -
4H5V
9
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
72.00
47%
-70
- C2 -
4IO8
1
HS71A_HUMAN
A:
[7-379]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
G
-
D
P
---------------------------
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
D
T
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
T
G-----
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
71.99
47%
-71
- C2 -
2E8A
2
HS71A_HUMAN
A:
[10-385]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
G
-
D
P
---------------------------
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
E
T
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
T
G-----
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
71.86
47%
-68
- C2 -
3ATU
4
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
G
-
D
P
---------------------------
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
E
T
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
T
G-----
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
71.85
48%
-74
- C2 -
3LDP
1
GRP78_HUMAN
A:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
N
-
D
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
V
D
--
I
---------------------------
G
G
G
Q
T
K
T
---------------------------
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
-
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
--
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
71.82
46%
-71
- C2 -
1QQN
6
HSP7C_BOVIN
A:
[4-378]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
A
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
A
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
A
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
A
H
A
K
D
I
S
E
N
K
R
A
V
R
R
L
A
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
71.72
47%
-70
- C2 -
3AY9
5
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
G
-
D
P
---------------------------
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
E
T
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
T
G-----
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
71.72
48%
-73
- C2 -
3IUC
2
GRP78_HUMAN
A:
[28-404]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
N
-
D
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
V
D
--
I
---------------------------
G
G
G
Q
T
K
T
---------------------------
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
-
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
--
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
71.70
46%
-69
- C2 -
4H5W
5
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
71.69
46%
-75
- C2 -
1BA0
5
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K-
K
-
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
K
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
71.65
46%
-73
- C2 -
1HX1
1
HSP7C_BOVIN
A:
[26-400]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
71.58
46%
-67
- C2 -
4H5R
10
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
71.45
46%
-67
- C2 -
4H5R
8
HSP7C_HUMAN
B:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
VQSDMKHWPFMVVNDAGRPKVQVEYKG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
71.34
47%
-71
- C2 -
1S3X
5
HS71A_HUMAN
A:
[7-382]
------
I
G
I
D
L
G
T
T
Y
S
C
I
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
G
-
D
P
---------------------------
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
E
T
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
T
G-----
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.29
50%
-68
- C2 -
3QFU
3
GRP78_YEAST
A:
[20-394]
-----
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
--
D
D
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
-
T
I
F
D
I
K
R
L
I
G
L
K
Y
N
-
D
R
---------------------------
S
---------------------------
V
Q
---
K
D
I
K
H
LP
F
N
V
V
N
K
DG
K
P
A
V
E
V
S
V
KG
E
K
K
V
F
T
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
-
S
------
D
K
-
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
----
E
N
G
V
F
E
V
--
Q
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
-
M
S
T
R
I
E
I
D
S
F
V
D
G
----
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
-
K
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.23
47%
-69
- C2 -
3JXU
2
HS71A_HUMAN
A:
[29-403]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
G
-
D
P
---------------------------
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
E
T
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
T
G-----
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
70.89
48%
-65
- C2 -
3FE1
4
HSP76_HUMAN
B:
[23-403]
M
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
A
-
D
T
---------------------------
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
R
V
C
Y
RG
E
D
---
K
T
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
R
------
G
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
70.84
48%
-73
- C2 -
3LDL
2
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
N
-
D
P
SVQQDIKFLPFKVVEKKTKPYIQVD--
I
---------------------------
G
G
GQT
K
T
---------------------------
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
-
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
--
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
70.80
47%
-70
- C2 -
3A8Y
1
HS71A_HUMAN
B:
[11-385]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
G
-
D
P
---------------------------
V
V
Q
S
D
M
K
HWP
F
Q
V
I
N
D
GD
K
P
K
V
Q
V
S
Y
KG
E
T
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
T
G--------
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
70.72
46%
-66
- C2 -
4H5N
9
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
V
E
Y
KG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
70.67
46%
-70
- C2 -
4H5W
4
HSP7C_HUMAN
B:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
-
T
V
F
D
A
K
R
L
I
G
R
R
F
D
-
D
A
---------------------------
V
VQSDMKHWPFMVVNDAGRPKVQVEYKG
E
T
---
K
S
---------------------------
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
K
V
------
G
A
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
--
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
70.57
47%
-69
- C2 -
3GDQ
3
HS71L_HUMAN
A:
[31-406]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
Q
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
N
-
D
P
---------------------------
V
V
Q
A
D
M
K
L
WP
F
Q
V
I
N
E
GG
K
P
K
V
L
V
S
Y
KG
E
N
---
K
A
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
T
K
L
K
E
T
A
E
A
F
L
G
H
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
G----------
E
R
H
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
S
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
N
L
E
I
D
S
L
Y
E
G
--
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
M
D
K
A
K
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
R
L
L
Q
D
Y
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
70.00
48%
-71
- C2 -
3IUC
3
GRP78_HUMAN
C:
[28-406]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
N
-
D
P
SVQQDIKFLPFKVVEKKTKPYIQVD--
I
---------------------------
G
G
GQT
K
T
---------------------------
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---------
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
--
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
69.98
48%
-67
- C2 -
3FE1
2
HSP76_HUMAN
A:
[23-403]
M
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
A
-
D
T
---------------------------
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
R
V
C
Y
RG
E
D
---
K
T
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
R
------
G
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
69.91
48%
-67
- C2 -
3FE1
2
HSP76_HUMAN
C:
[24-402]
-
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
-
T
V
F
D
A
K
R
L
I
G
R
K
F
A
-
D
T
---------------------------
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
R
V
C
Y
RG
E
D
---
K
T
---------------------------
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
-
R
------
G
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
--
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
---
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
--
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
69.74
48%
-69
- C2 -
3LDL
1
GRP78_HUMAN
A:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
N
-
D
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
V
D--
I
---------------------------
G
G
G
Q
T
K
T
---------------------------
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
-
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
--
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.73
48%
-68
- C2 -
3LDO
1
GRP78_HUMAN
A:
[7-384]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
N
-
D
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
V
D
--
I
---------------------------
G
G
G
Q
T
K
T
---------------------------
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
-
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
--
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
69.40
48%
-68
- C2 -
3LDO
1
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
N
-
D
P
SVQQDIKFLPFKVVEKKTKPYIQVD--
I
---------------------------
G
G
GQT
K
T
---------------------------
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
-
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
--
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
69.39
48%
-67
- C2 -
3LDP
1
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
-
T
V
F
D
A
K
R
L
I
G
R
T
W
N
-
D
P
SVQQDIKFLPFKVVEKKTKPYIQVD--
I
---------------------------
G
G
GQT
K
T
---------------------------
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
-
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
--
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------