@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1477: (2016-03-25 )
MKNNVLVTGGTGFLGMHIIFQLLQQGYQVKTTVRSLKSKEKVIEILQNNGITDFTHLSFVELDLSKDEGWKEAMLDCEYVLSVASPVFFGKFKNEEELISPAIEGITRILQAAKEAKVKRVVMTSNFGAIGFSNADKNSITTEAYWTDELAKGLSAYEKSKLIAEKEAWKFMENETELEFATINPVAIFGPSQSNHVSGSFDLLKNLLNGSMKRVINIPLNVVDARDVADLHIRAMITPEANGERFIASADGEISMADIAHLLQRERPELVDKMPKKTLPNAAIRAAALFSKHAKEGELMINMNRQISNSKARDVLGWKPISTKEEAVLAAVDSLAKYGLLD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.....----...70........80........90........100.......110....---.-..120.......130-.-..-...--.--140-----......--.---.150..-.----.--...160.......170.---......180.......190...-----....200.......210..-..-------....220........230.......240.......250.......260.......270.......280.......290.......300.......310.......320........330.......340-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKN
N
V
L
V
TGG
T
G
F
L
G
M
H
I
I
F
Q
L
L
QQGYQ
V
K
T
T
V
R
S
L
K
S
K
E
K
V
I
E
I
L
QNNGITDF
T
H
L
S
F
V
E
L
DLSK----DE
G
W
K
E
A
ML
D
C
E
Y
V
L
S
VAS
P
V
F
F
GKFK
N
E
E
E
L
I
S
P
A
I
E
G
I
T
R
I
L
Q
A
A
K
E
A---K-
V
K
R
V
V
M
TSNFGAIGF-S-NA-DKN--S--IT------T
E
A
Y
W
T
--
D
---
E
L
A
K
G
L
-
S
----
A
--
Y
E
K
S
K
L
I
A
E
K
E
A
W
K
F
ME---NET
E
L
E
F
A
TIN
P
V
A
I
FGPSQSN-----HVSG
S
F
D
L
L
K
N
L
L
N
G
S
-
M
K
-
R
V
-------
I
NIP
L
-
N
VVDARD
V
A
D
L
H
I
R
A
M
ITPEANG
E
R
F
I
ASADGEI
S
M
A
D
I
A
H
L
L
Q
RE
R
P
E
L
V
D
KMPKKTL
P
N
A
A
I
R
A
A
A
L
F
S
K
HAKEG
E
L
M
I
N
MNRQISNSKARDVLGWKP-IS
T
K
E
E
A
V
L
A
A
V
D
S
L
A
KYGLLD-
172
Fugue
94.50
28%
-85
- C3 -
4QTZ
-
?
A:
[1-321]
L
G
N
V
V
C
V
T
G
A
S
G
Y
I
A
S
W
L
V
R
L
L
L
H
R
G
Y
T
V
K
A
T
V
R
D
P
N
D
P
K
K
V
D
H
L
V
K
L
D
G
A
K
E
R
--
L
Q
L
F
K
A
N
L
L
E
----
E
G
A
F
D
S
V
V
Q
G
C
H
G
V
F
H
T
A
S
P
F
Y
H
D
V
K
D
P
Q
A
E
L
I
D
P
A
L
K
G
T
L
N
V
L
N
S
C
A
K
S
---
P
S
L
K
R
V
V
L
T
S
S
I
A
A
V
A
Y
-
N
-
G
K
-
P
R
T
--
P
DV
V
V
------
D
E
T
W
F
T
D
A
D
---
F
C
A
K
S
N
-
L
----
W
--
Y
V
V
S
K
T
L
A
E
E
A
A
W
K
F
V
K
---
E
N
-
N
I
D
M
V
T
I
N
P
A
M
V
I
G
P
L
L
Q
P
-----
V
L
N
T
S
A
A
A
I
L
N
L
I
N
G
A
--
Q
-
T
F
-------
P
N
A
S
F
-
G
W
V
N
V
K
D
V
A
N
A
H
I
L
A
Y
E
N
A
S
A
S
G
R
H
C
L
V
--
E
R
V
A
H
Y
S
E
V
V
R
I
L
R
E
L
Y
P
S
L
--
Q
L
P
E
K
C
A
D
D
K
P
Y
V
P
I
-----------------
Y
Q
V
S
K
E
K
A
K
S
-
L
G
L
-
E
-
Y
T
P
L
E
V
S
I
K
E
T
V
E
S
L
K
E
K
K
F
A
N
L
3
PsiBlast_PDB
92.12
31%
-92
* C2 *
4PVC
-
GRE2_YEAST
A:
[2-291]
---
S
V
F
V
S
G
A
N
G
F
I
A
Q
H
I
V
D
L
L
L
K
E
D
Y
K
V
I
G
S
A
R
S
Q
E
K
A
E
N
L
T
E
A
F
G
N
N
P
K
F
S
M
E
----
V
V
P
D
I
S
K
LDAF
D
H
V
F
Q
K
H
G
K
D
I
K
I
V
L
H
T
A
S
P
F
C
F
D
I
T
D
S
E
R
D
L
L
I
P
A
V
N
G
V
K
G
I
L
H
S
I
K
K
Y
AAD
S
-
V
E
R
V
V
L
T
S
S
Y
A
A
V
-
F
-
D
-
M
A
-
K
E
N
DK
S
--
L
T
F
N
EESW
N
P
A
T
W
E
--
S
---
C
Q
S
D
P
V
-
N
----
A
--
Y
C
G
S
K
K
F
A
E
K
A
A
W
E
F
L
E
E
N
R
D
S
V
K
F
E
L
T
A
V
N
P
V
Y
V
F
G
P
Q
M
F
D
KDVKK
H
L
N
T
S
C
E
L
V
N
S
L
M
H
L
S
-
P
E
D
K
I
-------
P
E
L
F
G
-
G
Y
I
D
V
R
D
V
A
K
A
H
L
V
A
F
Q
K
R
E
T
I
G
Q
R
L
I
V
S
-
E
A
R
F
T
M
Q
D
V
L
D
I
L
N
E
D
F
P
V
L
K
G
N
I
P
---------------------------------------------------------------------
22
PsiBlast_CBE
91.08
31%
-88
- C2 -
4PVD
1
GRE2_YEAST
B:
[2-291]
---
S
V
F
V
S
G
A
N
G
F
I
A
Q
H
I
V
D
L
L
L
K
E
D
Y
K
V
I
G
S
A
R
S
Q
E
K
A
E
N
L
T
E
A
F
G
N
N
P
K
F
S
M
E
----
V
V
P
D
I
S
K
LDAF
D
H
V
F
Q
K
H
G
K
D
I
K
I
V
L
H
T
A
S
P
F
C
F
D
I
T
D
S
E
R
D
L
L
I
P
A
V
N
G
V
K
G
I
L
H
S
I
K
K
Y
AAD
S
-
V
E
R
V
V
L
T
S
S
Y
A
A
V
-
F
-
D
-
M
A
-
K
E
N
DK
S
--
L
T
F
N
E
E
S
W
N
P
A
T
W
E
--
S
---
C
Q
S
D
P
V
-
N
----
A
--
Y
C
G
S
K
K
F
A
E
K
A
A
W
E
F
L
E
ENR
D
S
V
K
F
E
L
T
A
V
N
P
V
Y
V
F
G
P
Q
M
F
D
K
D
V
K
K
H
L
N
T
S
C
E
L
V
N
S
L
M
H
L
S
-
P
E
D
K
I
-------
P
E
L
F
G
-
G
Y
I
D
V
R
D
V
A
K
A
H
L
V
A
F
Q
K
R
E
T
I
G
Q
R
L
I
V
S
-
E
A
R
F
T
M
Q
D
V
L
D
I
L
N
E
D
F
P
V
L
K
G
N
I
P
---------------------------------------------------------------------
4
PsiBlast_PDB
90.73
31%
-87
- C2 -
4PVD
1
GRE2_YEAST
A:
[2-291]
---
S
V
F
V
S
G
A
N
G
F
I
A
Q
H
I
V
D
L
L
L
K
E
D
Y
K
V
I
G
S
A
R
S
Q
E
K
A
E
N
L
T
E
A
F
G
N
N
P
K
F
S
M
E
----
V
V
P
D
I
S
K
LDAF
D
H
V
F
Q
K
H
G
K
D
I
K
I
V
L
H
T
A
S
P
F
C
F
D
I
T
D
S
E
R
D
L
L
I
P
A
V
N
G
V
K
G
I
L
H
S
I
K
K
Y
AAD
S
-
V
E
R
V
V
L
T
S
S
Y
A
A
V
-
F
-
D
-
M
A
-
K
E
N
DK
S
--
L
T
F
N
EESW
N
P
A
T
W
E
--
S
---
C
Q
S
D
P
V
-
N
----
A
--
Y
C
G
S
K
K
F
A
E
K
A
A
W
E
F
L
E
E
N
R
D
S
V
K
F
E
L
T
A
V
N
P
V
Y
V
F
G
P
Q
M
F
D
KDVKK
H
L
N
T
S
C
E
L
V
N
S
L
M
H
L
S
-
P
E
D
K
I
-------
P
E
L
F
G
-
G
Y
I
D
V
R
D
V
A
K
A
H
L
V
A
F
Q
K
R
E
T
I
G
Q
R
L
I
V
S
-
E
A
R
F
T
M
Q
D
V
L
D
I
L
N
E
D
F
P
V
L
K
G
N
I
P
---------------------------------------------------------------------
31
PsiBlast_CBE
90.01
31%
-91
- C2 -
3BXX
4
DFRA_VITVI
B:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
D
F
E
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
MEF
C
R
A
K
K
M
-
T
----
A
WM
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
155
HHSearch
89.35
29%
-87
- C3 -
2RH8
1
?
A:
[9-336]
-
K
K
T
A
C
V
V
G
G
T
G
F
V
A
S
L
L
V
K
L
L
L
Q
K
G
Y
A
V
N
T
T
V
R
D
P
D
N
Q
K
-
K
V
S
H
L
L
E
L
--
Q
E
L
G
D
L
K
I
F
R
A
D
L
T
D
----
E
L
S
F
E
A
P
I
A
G
C
D
F
V
F
H
V
A
T
P
V
H
F
---------
I
K
P
A
I
Q
G
V
V
N
V
M
K
A
C
T
R
A
K--
S
-
V
K
R
V
I
L
T
S
S
A
A
A
V
T
I
-
N
-
Q
L
D
G
T
G
--
L
--
V
V
------
D
E
K
N
W
T
--
D
---
I
--
P
P
T
-
W
----
G
--
Y
P
A
S
K
T
L
A
E
K
A
A
W
K
F
A
E
---
E
-
N
N
I
D
L
I
T
V
I
P
T
L
M
A
G
S
S
L
T
S
-----
D
V
P
S
S
I
G
L
A
M
S
L
I
T
G
N
E
F
L
-
I
N
G
M
K
G
M
Q
M
L
S
G
S
V
-
S
I
A
H
V
E
D
V
C
R
A
H
I
F
V
A
E
K
E
S
A
-
S
G
R
Y
I
C
-
C
A
A
N
T
S
V
P
E
L
A
K
F
L
S
K
R
Y
P
Q
Y
K
--
V
P
T
D
F
G
-
D
--------
F
P
----
P
-----
K
S
K
L
I
I
S
S
E
K
L
V
K
-
E
G
F
S
F
K
Y
G
I
E
E
-
I
Y
D
E
S
V
E
Y
F
K
A
K
G
L
L
--
23
PsiBlast_CBE
89.23
32%
-99
- C2 -
4R1S
2
?
B:
[13-270]
----
V
C
V
T
G
A
G
G
F
I
A
S
W
L
V
K
I
L
L
E
K
G
Y
T
V
R
G
T
V
R
N
-
P
D
D
P
K
N
G
H
L
R
E
L
E
G
A
K
E
--
R
L
T
L
C
K
A
D
L
L
D
----
Y
Q
S
L
R
E
A
I
N
G
C
D
G
V
F
H
T
A
S
P
V
T
----
D
D
P
E
Q
M
V
E
P
A
V
I
G
T
K
N
V
I
N
A
A
A
E
A
---
N
-
V
R
R
V
V
F
T
S
S
I
G
A
V
Y
M
D
P
-
N
R
-
D
P
E
--
T
--
V
V
------
D
E
T
C
W
S
--
D
P--
D
F
C
K
N
T
K
N
----
W
--
Y
C
Y
G
K
M
V
A
E
Q
A
A
W
E
E
A
K
----
E
K
G
V
D
L
V
V
I
N
P
V
L
V
Q
G
P
L
L
Q
T
-----
T
V
N
A
S
V
L
H
I
L
K
Y
L
T
G
S
-
A
K
-
T
Y
-------
A
N
S
V
Q
-
A
Y
V
D
V
K
D
V
A
L
A
H
I
L
L
Y
E
T
P
E
A
S
G
-
R
Y
L
C
-
A
E
S
V
L
H
R
G
D
V
V
E
I
L
S
K
F
F
P
E
---------------------------------------------------------------------------
30
PsiBlast_CBE
88.36
31%
-85
- C2 -
3BXX
4
DFRA_VITVI
C:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
D
F
E
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
MEF
C
R
A
K
K
M
-
T
----
A
WM
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
28
PsiBlast_CBE
88.18
31%
-84
- C2 -
3BXX
1
DFRA_VITVI
E:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
D
F
E
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
MEF
C
R
A
K
K
M
-
T
----
A
WM
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
27
PsiBlast_CBE
88.08
31%
-89
- C2 -
3BXX
3
DFRA_VITVI
F:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
D
F
E
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
MEF
C
R
A
K
K
M
-
T
----
A
WM
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
32
PsiBlast_CBE
87.73
31%
-92
- C2 -
2NNL
2
DFRA_VITVI
F:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
D
F
E
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
MEF
C
R
A
K
K
M
-
T
----
A
WM
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
8
PsiBlast_PDB
87.72
31%
-90
- C2 -
2NNL
2
DFRA_VITVI
D:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
D
F
E
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
MEF
C
R
A
K
K
M
-
T
----
A
WM
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
34
PsiBlast_CBE
87.63
31%
-87
- C2 -
2IOD
3
DFRA_VITVI
C:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
D
F
E
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
M
E
F
C
R
A
K
K
M
-
T
----
A
W
M
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
25
PsiBlast_CBE
87.63
31%
-87
- C2 -
3C1T
3
DFRA_VITVI
C:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
D
F
E
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
M
E
F
C
R
A
K
K
M
-
T
----
A
W
M
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
12
PsiBlast_PDB
87.38
29%
-112
- C2 -
4R1U
1
?
A:
[30-294]
----
V
C
V
T
G
A
G
G
F
I
A
S
W
L
V
K
L
L
L
E
R
G
Y
T
V
R
G
T
V
R
N
P
E
D
P
-
K
N
G
H
L
K
E
L
E
G
A
R
E
--
R
L
T
L
H
K
V
D
L
L
D
----
L
Q
S
I
Q
S
V
V
H
G
C
H
G
V
F
H
T
A
----------
P
D
E
M
L
E
P
A
V
N
G
T
K
N
V
I
I
A
S
A
E
A
---
K
-
V
R
R
V
V
F
T
S
S
I
G
T
V
Y
M
-
D
P
N
T
-
S
R
D
--
V
--
V
V
------
D
E
S
Y
W
S
--
D
L
--
E
H
C
K
N
T
K
N
----
W
--
Y
C
Y
G
K
T
V
A
E
Q
S
A
W
D
I
A
K
----
E
N
Q
V
D
L
V
V
V
N
P
V
V
V
L
G
P
L
L
Q
P
-----
T
I
N
A
S
T
I
H
I
L
K
Y
L
N
G
A
-
A
K
-
T
Y
-------
V
N
A
T
Q
-
S
Y
V
H
V
K
D
V
A
L
A
H
L
L
V
Y
E
T
N
S
A
S
G
-
R
Y
I
C
-
C
E
T
A
L
H
R
G
E
V
V
E
I
L
A
K
Y
F
P
E
Y
--
P
L
P
T
K
C
------------------------------------------------------------------
36
PsiBlast_CBE
87.37
31%
-89
- C2 -
2C29
2
?
F:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
D
F
E
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
MEF
C
R
A
K
K
M
-
T
----
A
WM
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
35
PsiBlast_CBE
87.23
31%
-89
- C2 -
2IOD
3
DFRA_VITVI
B:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
---
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
M
E
F
C
R
A
K
K
M
-
T
----
A
W
M
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
26
PsiBlast_CBE
87.23
31%
-89
- C2 -
3C1T
3
DFRA_VITVI
B:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
---
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
M
E
F
C
R
A
K
K
M
-
T
----
A
W
M
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
29
PsiBlast_CBE
87.17
31%
-87
- C2 -
3BXX
4
DFRA_VITVI
D:
[7-273]
---
T
V
C
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
E
R
G
Y
T
V
R
A
T
V
R
D
P
T
N
V
K
K
V
K
H
L
L
D
L
P
K
A
E
--
T
H
L
T
L
W
K
A
D
L
A
D
----
E
G
S
F
D
E
A
I
K
G
C
T
G
V
F
H
V
A
T
P
M
D
F
E
S
K
D
P
E
N
E
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
---
K
T
V
R
R
L
V
F
T
S
S
A
G
T
V
N
I
-
Q
-
E
--
H
Q
L
--
P
--
V
Y
------
D
E
S
C
W
S
--
D
MEF
C
R
A
K
K
M
-
T
----
A
WM
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
----
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
-----
S
M
P
P
S
L
I
T
A
L
S
P
I
T
G
N
-
E
A
-
H
Y
-------
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
P
K
A
E
G
-
R
Y
I
C
S
S
H
D
C
I
-
I
L
D
L
A
K
M
L
R
E
K
Y
P
E
---------------------------------------------------------------------------
171
Fugue
87.13
27%
-75
- C3 -
2P4H
-
VESTR_MEDSA
X:
[5-326]
-
K
G
R
V
C
V
T
G
G
T
G
F
L
G
S
W
I
I
K
S
L
L
E
N
G
Y
S
V
N
T
T
I
R
A
D
R
D
V
S
F
L
T
N
L
---
P
G
A
S
E
K
--
L
H
F
F
N
A
D
L
S
N
----
P
D
S
F
A
A
A
I
E
G
C
V
G
I
F
H
T
A
S
P
I
--------
E
I
V
T
K
R
T
V
D
G
A
L
G
I
L
K
A
C
V
N
S
---
K
T
V
K
R
F
I
Y
T
S
S
G
S
A
V
S
F
-
N
-
G
K
-
D
K
D
--
V
--
L
D
------
E
S
D
W
S
D
--
V
---
D
L
L
R
S
V
-
K
PFGW
N
--
Y
A
V
S
K
T
L
A
E
K
A
V
L
E
F
G
E
---
Q
-
N
G
I
D
V
V
T
L
I
L
P
F
I
V
G
R
F
V
C
P
-----
K
L
P
D
S
I
E
K
A
L
V
L
V
L
G
K
-
K
E
-
Q
I
-------
G
V
T
R
F
-
H
M
V
H
V
D
D
V
A
R
A
H
I
Y
L
L
E
N
S
V
P
G
G
-
R
Y
N
C
S
-
P
F
I
V
P
I
E
E
M
S
Q
L
L
S
A
K
Y
P
E
Y
--
Q
I
L
T
V
------------
D
E
L
K
E
I
K
G
A
R
----
L
P
D
L
N
T
K
K
L
V
D
-
A
G
F
D
F
-
K
Y
T
I
E
D
M
F
D
D
A
I
Q
C
C
K
E
K
G
Y
L
--