@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1537: (2016-03-25 )
MFVDQVKIYVKAGNGGDGMVAFRREKFVPNGGPAGGDGGKGADVVFVVDEGLRTLVDFRFKRIFKAEHGEHGMSKSMHGRGAEDLVVKVPQGTIVKDIDTGEIIADLVAHGQRAVIAKAGRGGRGNKRFATPANPAPELSENGEPGQERNVQLELKVLADVGLVGFPSVGKSTLLSVVSAARPKIAAYHFTTIVPNLGMVDAGDGRSFVMADLPGLIEGASQGVGLGHQFLRHIERTRVIVHVIDMSGSEGRVPYEDYMAINNELEQYNLRLMERPQIIVANKMDMPDAEENLNEFKTKIAEDIPVFPISAVTKTGLRELLLAIADKLETTPEFPLNEILEQEDEDTVLYKYVAEEPDFEISREPDGTFVLSGAKIERLFTMTNFERDASISRFARQLRAMGVDEALRKRGAKDGDIVRLLDYEFEFMD
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170...-----....180.-.-.....190.....--..200...--------------------....210------------------.......--------..220---...--....230---........240..------.....250.......260......--.---------------------------------------------------------270...--....-280...---...---.---290---.----.---..----....300--------.-.---.-......310.......320...----...-.330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
F
V
D
Q
V
K
I
Y
V
K
AGNGGDG
M
V
A
F
R
REKFVPNGGPAGGDGGKG
A
D
V
V
F
V
V
D
E
G
L
R
T
L
V
D
F
R
F
K
R
I
F
K
A
EHGEHGMSKSMHGRGAE
D
L
V
V
KVPQG
T
I
V
K
DID
T
G
E
I
I
A
D
L
V
AHG
Q
R
A
V
I
A
KAGRGGRGNKRFATPANPAPELSENGEPGQER
N
V
Q
L
E
L
K
V
L
A
DVGLVGFPSV
G
K
S
T
L
L
-----
S
V
V
S
AARP-
K
-
I
A
A
Y
H
F
T
T
IVPNL--G
M
V
DAGDG--------------------
R
S
F
V
M
--------------------
A
DL
P
G
L
I
--------
E
GASQ---G
V
G
--
L
G
H
Q
F
L
----
R
H
I
E
R
T
R
V
I
V
H
V
I
------DMSGSEGRV
P
Y
E
D
Y
M
A
I
N
N
E
L
E
Q
Y
--
N
---------------------------------------------------------
L
R
LMER--P
Q
I
I
-
V
A
NKMD---MP
D
---
A
---
E
E
----
N
----
L
---
N
E
----
F
K
T
K
I
----------A-E---D-IPVF
P
I
S
A
V
T
K
T
G
L
R
E
L
L
L
A
I
A
----
D
K
L-ETTPEF
P
L
N
E
I
L
EQEDED
T
V
L
Y
K
YVAEEPDF
E
I
SREPDG
T
F
V
LSG
A
K
I
E
R
L
F
T
MTNFERD
A
S
I
S
R
F
A
R
Q
L
R
AM
G
V
D
E
A
L
R
KRGAKDG
D
I
V
R
L
L
D
Y
E
F
EFMD--
28
HHSearch
85.09
79%
-84
- C2 -
1LNZ
2
OBG_BACSU
A:
[1-334]
M
F
V
D
Q
V
K
V
Y
V
K
G
G
D
G
G
N
G
M
V
A
F
R
R
E
K
Y
V
P
K
G
G
P
A
G
G
D
G
G
K
G
G
D
V
V
F
E
V
D
E
G
L
R
T
L
M
D
F
R
Y
K
K
H
F
K
A
I
R
G
E
H
G
M
S
K
N
Q
H
G
R
N
A
D
D
M
V
I
K
V
P
P
G
T
V
V
T
D
D
D
T
K
Q
V
I
A
D
L
T
E
H
G
Q
R
A
V
I
A
R
G
G
R
G
G
R
G
N
S
R
F
A
T
P
A
N
P
A
P
Q
L
S
E
N
G
E
P
G
K
E
R
Y
I
V
L
E
L
K
V
L
A
D
V
G
L
V
G
F
P
S
V
G
K
S
T
L
L
-----
S
V
V
S
S
A
K
P
-
K
-
I
A
D
Y
H
F
T
T
L
V
P
N
L
--
G
M
V
E
T
D
D
G
--------------------
R
S
F
V
M
--------------------
A
D
L
P
G
L
I
--------
E
G
A
H
Q
---
G
V
G
--
L
G
H
Q
F
L
----
R
H
I
E
R
T
R
V
I
V
H
V
I
------
D
M
S
G
L
E
G
R
D
P
Y
D
D
Y
L
T
I
N
Q
E
L
S
E
Y
--
N
---------------------------------------------------------
L
R
L
T
E
R
--
P
Q
I
I
-
V
A
N
K
M
D
---
M
P
E
---
A
---
A
E
----
N
----
L
---
E
A
----
F
K
E
K
L
----------
T
-
D
---
D
-
Y
P
V
F
P
I
S
A
V
T
R
E
G
L
R
E
L
L
F
E
V
A
----
N
Q
L
-
E
N
T
P
E
F
-------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.96
76%
-82
- C2 -
1LNZ
2
OBG_BACSU
A:
[2-336]
-
F
V
D
Q
V
K
V
Y
V
K
G
G
D
G
G
N
G
M
V
A
F
R
R
E
K
Y
V
P
K
G
G
P
A
G
G
D
G
G
K
G
G
D
V
V
F
E
V
D
E
G
L
R
T
L
M
D
F
R
Y
K
K
H
F
K
A
I
R
G
E
H
G
M
S
K
N
Q
H
G
R
N
A
D
D
M
V
I
K
V
P
P
G
T
V
V
T
D
D
D
T
K
Q
V
I
A
D
L
T
E
H
G
Q
R
A
V
I
A
R
G
G
R
G
G
R
G
N
S
R
F
A
T
P
A
N
P
A
P
Q
L
S
E
N
G
E
P
G
K
E
R
Y
I
V
L
E
L
K
V
L
A
D
V
G
L
V
G
F
P
S
V
G
K
S
T
L
L
-----
S
V
V
S
S
A
K
P
-
K
-
I
A
D
Y
H
F
T
T
L
V
P
N
L
--
G
M
V
E
T
D
D
G
--------------------
R
S
F
V
M
--------------------
A
D
L
P
G
L
I
--------
E
G
A
H
Q
---
G
V
G
--
L
G
H
Q
F
L
----
R
H
I
E
R
T
R
V
I
V
H
V
I
------
D
M
S
G
L
E
G
R
D
P
Y
D
D
Y
L
T
I
N
Q
E
L
S
E
Y
--
N
---------------------------------------------------------
L
R
L
T
E
R
--
P
Q
I
I
-
V
A
N
K
M
D
---
M
P
E
---
A
---
A
E
----
N
----
L
---
E
A
----
F
K
E
K
L
----------
T
-
D
---
D
-
Y
P
V
F
P
I
S
A
V
T
R
E
G
L
R
E
L
L
F
E
V
A
----
N
Q
L
-
E
N
T
P
E
F
P
L
-----------------------------------------------------------------------------------------------
27
HHSearch
83.04
42%
-72
- C2 -
1UDX
3
OBG_THET8
A:
[1-414]
M
F
Q
D
V
L
V
I
T
V
A
A
G
R
G
G
D
G
A
V
S
F
R
R
E
K
F
V
P
K
G
G
P
D
G
G
D
G
G
R
G
G
S
V
Y
L
R
A
R
G
S
V
D
S
L
S
R
L
S
-
K
R
T
Y
K
A
E
D
G
E
H
G
R
G
S
Q
Q
H
G
R
G
G
E
D
L
V
I
E
V
P
R
G
T
R
V
F
D
A
D
T
G
E
L
L
A
D
L
T
E
E
G
Q
T
V
L
V
A
R
G
G
A
G
G
R
G
N
M
H
F
V
S
P
T
R
Q
A
P
R
F
A
E
A
G
E
E
G
E
K
R
R
L
R
L
E
L
M
L
I
A
D
V
G
L
V
G
Y
P
N
A
G
K
S
S
L
L
-----
A
A
M
T
R
A
H
P
-
K
-
I
A
P
Y
P
F
T
T
L
S
P
N
L
--
G
V
V
E
V
S
E
E
--------------------
E
R
F
T
L
--------------------
A
D
I
P
G
I
I
--------
E
G
A
S
E
---
G
K
G
--
L
G
L
E
F
L
----
R
H
I
A
R
T
R
V
L
L
Y
V
L
------
D
A
A
D
----
E
P
L
K
T
L
E
T
L
R
K
E
V
G
A
Y
--
D
---------------------------------------------------------
P
A
L
L
R
R
--
P
S
L
V
-
A
L
N
K
V
D
---
L
L
E
---
E
---
E
A
---------
V
---
K
A
----
L
A
D
A
L
A
---------
R
-
E
---
G
-
L
A
V
L
P
V
S
A
L
T
G
A
G
L
P
A
L
K
E
A
L
H
----
A
L
V
-
R
S
T
P
P
P
E
M
P
K
P
V
----
P
----------
Q
A
G
V
E
V
V
P
V
A
E
G
V
Y
E
V
R
A
P
E
V
E
R
Y
L
A
R
I
K
G
D
L
M
E
A
A
G
Y
L
Q
E
V
F
R
R
Q
G
V
E
A
A
L
R
A
K
G
V
R
A
G
D
L
V
R
I
G
G
L
E
F
E
Y
I
P
--
2
PsiBlast_PDB
82.71
41%
-73
- C2 -
1UDX
3
OBG_THET8
A:
[1-413]
M
F
Q
D
V
L
V
I
T
V
A
A
G
R
G
G
D
G
A
V
S
F
R
R
E
K
F
V
P
K
G
G
P
D
G
G
D
G
G
R
G
G
S
V
Y
L
R
A
R
G
S
V
D
S
L
S
R
L
S
-
K
R
T
Y
K
A
E
D
G
E
H
G
R
G
S
Q
Q
H
G
R
G
G
E
D
L
V
I
E
V
P
R
G
T
R
V
F
D
A
D
T
G
E
L
L
A
D
L
T
E
E
G
Q
T
V
L
V
A
R
G
G
A
G
G
R
G
N
M
H
F
V
S
P
T
R
Q
A
P
R
F
A
E
A
G
E
E
G
E
K
R
R
L
R
L
E
L
M
L
I
A
D
V
G
L
V
G
Y
P
N
A
G
K
S
S
L
L
-----
A
A
M
T
R
A
H
P
-
K
-
I
A
P
Y
P
F
T
T
L
S
P
N
L
--
G
V
V
E
V
S
E
E
--------------------
E
R
F
T
L
--------------------
A
D
I
P
G
I
I
--------
E
G
A
S
E
---
G
K
G
--
L
G
L
E
F
L
----
R
H
I
A
R
T
R
V
L
L
Y
V
L
------
D
A
A
D
E
----
P
L
K
T
L
E
T
L
R
K
E
V
G
A
Y
--
D
---------------------------------------------------------
P
A
L
L
R
R
--
P
S
L
V
-
A
L
N
K
V
D
---
L
L
E
-------
E
E
----
A
----
V
---
K
A
----
L
A
D
A
L
----------
A
R
E
---
G
-
L
A
V
L
P
V
S
A
L
T
G
A
G
L
P
A
L
K
E
A
L
H
----
A
L
V
-
R
S
T
P
P
P
E
M
P
K
P
V
P
--------------
Q
A
G
V
E
V
V
P
V
A
E
G
V
Y
E
V
R
A
P
E
V
E
R
Y
L
A
R
I
K
G
D
L
M
E
A
A
G
Y
L
Q
E
V
F
R
R
Q
G
V
E
A
A
L
R
A
K
G
V
R
A
G
D
L
V
R
I
G
G
L
E
F
E
Y
I
---
49
Fugue
82.21
42%
-68
- C2 -
1UDX
3
OBG_THET8
A:
[1-416]
M
F
Q
D
V
L
V
I
T
V
A
A
G
R
G
G
D
G
A
V
S
F
R
R
E
K
F
V
P
K
G
G
P
D
G
G
D
G
G
R
G
G
S
V
Y
L
R
A
R
G
S
V
D
S
L
S
R
L
S
-
K
R
T
Y
K
A
E
D
G
E
H
G
R
G
S
Q
Q
H
G
R
G
G
E
D
L
V
I
E
V
P
R
G
T
R
V
F
D
A
D
T
G
E
L
L
A
D
L
T
E
E
G
Q
T
V
L
V
A
R
G
G
A
G
G
R
G
N
M
H
F
V
S
P
T
R
Q
A
P
R
F
A
E
A
G
E
E
G
E
K
R
R
L
R
L
E
L
M
L
I
A
D
V
G
L
V
G
Y
P
N
A
G
K
S
S
L
L
-----
A
A
M
T
R
A
H
P
-
K
-
I
A
P
Y
P
F
T
T
L
S
P
N
L
--
G
V
V
E
V
S
E
E
--------------------
E
R
F
T
L
--------------------
A
D
I
P
G
I
I
--------
E
G
A
S
E
---
G
K
G
--
L
G
L
E
F
L
----
R
H
I
A
R
T
R
V
L
L
Y
V
L
------
D
A
A
D
E
----
P
L
K
T
L
E
T
L
R
K
E
V
G
A
Y
--
D
---------------------------------------------------------
P
A
L
L
R
R
--
P
S
L
V
-
A
L
N
K
V
D
---
L
L
E
---
E
---
E
A
----
V
----
K
---
A
L
----
A
D
A
L
A
----------
R
-
E
---
G
-
L
A
V
L
P
V
S
A
L
T
G
A
G
L
P
A
L
K
E
A
L
H
----
A
L
V
-
R
S
T
P
P
P
E
M
P
K
--------------
P
V
P
Q
A
G
V
E
V
V
P
V
A
E
G
V
Y
E
V
R
A
P
E
V
E
R
Y
L
A
R
I
K
G
D
L
M
E
A
A
G
Y
L
Q
E
V
F
R
R
Q
G
V
E
A
A
L
R
A
K
G
V
R
A
G
D
L
V
R
I
G
G
L
E
F
E
Y
I
P
EV
10
PsiBlast_PDB
52.59
31%
-88
- C2 -
3R9W
6
ERA_AQUAE
A:
[12-187]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
-
K
-
A
G
----
T
T
R
M
R
V
L
--
G
V
K
N
I
P
N
E
--------------------
A
Q
I
I
F
--------------------
L
D
T
P
G
I
Y
--------
E
P
K
K
S
---
D
V
---
L
G
H
S
M
V
E
I
A
K
Q
S
L
E
E
A
D
V
I
L
F
M
I
------
D
--
A
T
E
G
W
R
P
R
D
E
------
E
I
Y
Q
N
--
F
---------------------------------------------------------
I
K
P
L
N
K
--
P
V
I
V
-
V
I
N
K
I
D
---
K
I
G
---
P
---
A
K
----
N
V
L
P
L
I
---
D
E
----
I
H
K
K
H
----------
P
-
E
---
L
-
T
E
I
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
I
L
----
K
Y
L
P
E
G
E
P
L
F
P
------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
52.58
30%
-97
- C2 -
2DYK
1
?
A:
[4-160]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
R
P
N
V
G
K
S
S
L
F
-----
N
R
L
L
K
K
R
S
--------------
D
L
K
E
G
V
V
E
T
D
R
G
--------------------
R
-
F
L
L
--------------------
V
D
T
G
G
L
W
--------
S
G
D
K
W
---
E
K
K
--
I
Q
E
K
V
D
----
R
A
L
E
D
A
E
V
V
L
F
A
V
------
D
-----
G
R
A
---
E
L
T
Q
A
D
Y
E
V
A
E
Y
------------------------------------------------------------
L
R
R
K
G
K
--
P
V
I
L
-
V
A
T
K
V
D
---
D
P
K
---
H
---
E
L
----
Y
----
L
---
G
P
----
L
Y
G
L
G
----------
F
-
G
---
D
--
P
I
-
P
T
S
S
E
H
A
R
G
L
E
E
L
L
E
A
I
W
----
E
R
L
--------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
52.52
23%
-125
- C2 -
2WJI
3
FEOB_METJA
A:
[5-160]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
-----
N
A
L
T
G
E
N
V
-
Y
-
I
G
-----
T
V
E
K
K
E
--
G
E
F
E
Y
-
N
G
--------------------
E
K
F
K
V
--------------------
V
D
L
P
G
V
Y
--------
S
L
T
A
N
---
S
I
D
E
I
I
A
R
D
Y
I
----
I
N
-
E
K
P
D
L
V
V
N
I
V
------
D
A
T
A
L
E
R
N
L
----
Y
L
T
--------------------------------------------------------------------
L
Q
L
M
E
M
GA
N
L
L
L
-
A
L
N
K
M
D
---
L
A
K
---
S
L
GI
E
I
----
D
----
V
---
D
K
----
L
E
K
I
L
----------
G
-------
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
---------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
52.06
31%
-86
- C2 -
3IEV
2
ERA_AQUAE
A:
[13-188]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
-
K
-
A
G
----
T
T
R
M
R
V
L
--
G
V
K
N
I
P
N
E
--------------------
A
Q
I
I
F
--------------------
L
D
T
P
G
I
Y
--------
E
P
K
K
S
---
D
V
---
L
G
H
S
M
V
E
I
A
K
Q
S
L
E
E
A
D
V
I
L
F
M
I
------
D
--
A
T
E
G
W
R
P
R
D
E
------
E
I
Y
Q
N
--
F
---------------------------------------------------------
I
K
P
L
N
K
--
P
V
I
V
-
V
I
N
K
I
D
---
K
I
G
---
P
---
A
K
----
N
V
L
P
L
I
---
D
E
----
I
H
K
K
H
----------
P
-
E
---
L
-
T
E
I
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
I
L
----
K
Y
L
P
E
G
E
P
L
F
P
------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
51.12
31%
-82
- C2 -
3R9X
4
ERA_AQUAE
A:
[12-187]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
-
K
-
A
G
----
T
T
R
M
R
V
L
--
G
V
K
N
I
P
N
E
--------------------
A
Q
I
I
F
--------------------
L
D
T
P
G
I
Y
--------
E
P
K
K
S
---
D
V
---
L
G
H
S
M
V
E
I
A
K
Q
S
L
E
E
A
D
V
I
L
F
M
I
------
D
--
A
T
E
G
W
R
P
R
D
E
------
E
I
Y
Q
N
--
F
---------------------------------------------------------
I
K
P
L
N
K
--
P
V
I
V
-
V
I
N
K
I
D
---
K
I
G
---
P
---
A
K
----
N
V
L
P
L
I
---
D
E
----
I
H
K
K
H
----------
P
-
E
---
L
-
T
E
I
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
I
L
----
K
Y
L
P
E
G
E
P
L
F
P
------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.79
31%
-88
- C2 -
2E87
1
?
A:
[170-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
A
G
H
P
N
V
G
K
S
T
L
L
-----
K
A
L
T
T
A
K
P
-
E
-
I
A
S
Y
P
F
T
T
R
G
I
N
V
--
G
Q
F
E
D
G
Y
F
--------------------
R
-
Y
Q
I
--------------------
I
D
T
P
G
L
L
DRPISERN
E
I
E
K
Q
---
A
I
---
L
A
L
R
Y
L
----
G
N
L
-----
I
I
Y
I
F
------
D
P
S
E
H
C
G
-
F
P
L
E
E
Q
I
H
L
---
F
E
E
V
--
H
---------------------------------------------------------
G
E
F
K
D
L
--
P
F
L
V
-
V
I
N
K
I
D
---
V
A
D
-------
E
E
----
N
----
I
---
K
R
----
L
E
K
F
V
----------
K
-
E
---
K
G
L
N
P
I
K
I
S
A
L
K
G
T
G
I
-----------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
50.55
22%
-119
- C2 -
2WJJ
1
FEOB_METJA
A:
[6-161]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
-----
N
A
L
T
G
E
N
V
-
Y
-
I
G
N
W
P
G
V
T
V
E
K
K
E
--
G
E
F
E
Y
-
N
G
--------------------
E
K
F
K
V
--------------------
V
D
L
P
G
V
Y
--------
S
L
T
A
N
---
S
I
D
E
I
I
A
R
D
Y
I
----
I
N
-
E
K
P
D
L
V
V
N
I
V
------
D
A
T
A
L
E
R
N
L
----
Y
L
T
L
--
Q
L
M
E
M
--
G
---------------------------------------------------------
A
N
L
L
-------
L
-
A
L
N
K
M
D
---
L
A
K
---
S
L
GI
E
I
----
D
----
V
---
D
K
----
L
E
K
I
L
----------
G
-------
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
---------------------------------------------------------------------------------------------------------------
32
HHSearch
50.51
34%
-64
- C2 -
2DBY
3
?
A:
[2-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
V
G
I
V
G
L
P
N
V
G
K
S
T
L
F
-----
N
A
L
T
R
A
N
A
-
L
-
A
A
N
Y
P
F
A
T
I
D
K
N
V
--
G
V
V
P
L
E
D
E
R
L
Y
A
L
Q
R
T
F
AKGE
R
V
P
P
V
V
P
T
H
V
E
F
--------------------
V
D
I
A
G
L
V
--------
K
G
A
H
K
---
G
E
G
--
L
G
N
Q
F
L
----
A
H
I
R
E
V
A
A
I
A
H
V
L
------
R
C
F
P
D
P
----
L
E
D
A
E
V
V
E
T
E
L
L
L
A
--
D
L
A
T
L
E
R
R
L
E
R
L
R
K
E
A
R
A
D
RER
L
P
L
L
E
A
A
E
G
L
Y
V
H
L
Q
E
GKPARTFPPS
E
A
V
A
R
F
L
K
E
T
P
L
L
T
A
K
--
P
V
I
Y
-
V
A
N
V
A
E
---
E
D
L
---
P
---
D
G
RGN
P
Q
----
V
---
E
A
----
V
R
R
K
A
L
---------
E
-
E
---
G
-
A
E
V
V
V
V
S
A
R
L
E
A
E
L
A
E
L
S
G
E
E
----------------------------------------------------------------------------------------------------------------
34
HHSearch
50.46
27%
-87
- C2 -
3IEV
2
ERA_AQUAE
A:
[11-186]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
-----
N
N
L
L
G
T
K
V
-
S
I
I
S
P
K
A
G
T
T
R
M
R
V
L
--
G
V
K
N
I
P
N
E
--------------------
A
Q
I
I
F
--------------------
L
D
T
P
G
I
Y
--------
E
P
K
K
S
D
V
L
G
H
S
--
M
V
E
I
A
K
----
Q
S
L
E
E
A
D
V
I
L
F
M
I
------
D
A
T
E
---
G
W
R
P
R
D
E
E
I
Y
Q
N
F
I
K
----------------------------------------------------------------
P
L
N
K
--
P
V
I
V
-
V
I
N
K
I
D
---
K
I
G
---
P
---
A
K
----
N
----
V
---
L
P
L
I
D
E
I
H
K
K
H
----------
P
-
E
---
L
-
T
E
I
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
I
L
----
K
Y
L
-
P
E
G
E
P
L
-------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
49.77
25%
-104
- C2 -
3K53
-
?
A:
[2-175]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
T
V
A
L
V
G
N
P
N
V
G
K
T
T
I
F
-----
N
A
L
T
G
L
R
Q
-
H
-
V
G
N
W
P
G
V
T
V
E
K
K
E
--
G
I
M
E
Y
R
E
---------------------
K
E
F
L
V
--------------------
V
D
L
P
G
I
Y
--------
S
L
T
A
H
---
S
I
D
E
L
I
A
R
N
F
I
----
L
D
-
G
N
A
D
V
I
V
D
I
V
------
D
S
T
C
-----------
L
M
R
N
L
F
L
T
L
--
E
---------------------------------------------------------
L
F
E
M
E
V
--
K
N
I
I
L
V
L
N
K
F
D
---
L
L
K
K
K
G
A
---
K
I
----
D
----
I
---
K
K
----
M
R
K
E
L
----------
G
-------
V
P
V
I
P
T
N
A
K
K
G
E
G
V
E
E
L
K
R
M
I
A
L
M
A
E
G
K
V
-
T
T
N
P
I
I
P
------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
49.08
23%
-125
- C2 -
2WJH
3
FEOB_METJA
A:
[5-160]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
-----
N
A
L
T
G
E
N
V
-
Y
-
I
G
N
W
P
G
V
T
V
E
K
K
E
--
G
E
F
E
Y
-
N
G
--------------------
E
K
F
K
V
--------------------
V
D
L
P
G
V
Y
--------
S
L
T
A
N
---
S
I
D
E
I
I
A
R
D
Y
I
----
I
N
-
E
K
P
D
L
V
V
N
I
V
------
D
A
T
A
L
E
R
N
L
----
Y
L
T
--------------------------------------------------------------------
L
Q
L
M
E
M
GA
N
L
L
L
-
A
L
N
K
M
D
---
L
A
K
---
S
L
G
I
E
I
----
D
----
V
---
D
K
----
L
E
K
I
L
----------
G
-------
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
---------------------------------------------------------------------------------------------------------------
40
HHSearch
48.84
20%
-82
- C2 -
3B1V
3
?
A:
[3-164]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
E
I
A
L
I
G
N
P
N
S
G
K
T
S
L
F
-----
N
L
I
T
G
H
N
Q
-
R
-
V
G
N
W
P
G
V
T
V
E
R
K
S
--
G
L
V
K
--
K
N
--------------------
K
D
L
E
I
--------------------
Q
D
L
P
G
I
Y
--------
S
M
S
P
Y
S
P
-
E
A
K
--
V
A
R
D
Y
L
-----
L
S
Q
R
A
D
S
I
L
N
V
V
------
D
A
T
N
---
L
E
R
---
N
L
Y
L
T
T
Q
L
I
E
----------------------------------------------------------------
T
G
I
--
P
V
T
I
-
A
L
N
M
I
D
---
V
L
D
---
G
---
Q
G
----
K
----
K
IN
V
D
K
----
L
S
Y
H
-------------
L
---
G
-
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
----
H
T
T
-
T
S
-----------------------------------------------------------------------------------------------------
55
Fugue
48.56
16%
-88
- C2 -
1PUI
4
ENGB_ECOLI
A:
[11-198]
----------------------------------------------------------------------------------------------------------------------------------------------
F
V
M
S
A
P
D
I
R
H
L
P
S
D
T
G
I
E
V
A
F
A
G
R
S
N
A
G
K
S
S
A
L
-----
N
T
L
T
N
Q
Q
L
------
I
N
L
F
E
V
A
D
G
K
--
R
L
V
D
---------------------------------------------------
L
P
G
Y
G
--------
E
M
K
R
K
---
W
Q
R
--
A
L
G
E
Y
L
----
E
K
R
Q
S
L
Q
G
L
V
V
L
M
------
D
I
R
----
H
P
L
K
D
L
D
Q
Q
M
I
E
W
A
V
D
S
--
N
---------------------------------------------------------
I
-------
A
V
L
V
-
L
L
T
K
A
D
KLA
S
G
A
---
R
---
K
A
----
Q
----
L
---
N
M
----
V
R
E
A
V
----------
L
-
A
F
NG
D
-
V
Q
V
E
T
F
S
S
L
K
K
Q
G
V
D
K
L
R
Q
K
L
D
----
T
W
F
-
S
------------------------------------------------------------------------------------------------------
52
Fugue
48.42
23%
-82
- C2 -
1M2O
2
SAR1_YEAST
B:
[24-190]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
L
F
L
G
L
D
N
A
G
K
T
T
L
L
-----
H
M
L
K
N
D
R
L
-
A
----
T
L
Q
P
T
W
H
P
T
S
--
E
E
L
A
I
G
-
N
--------------------
I
K
F
T
T
--------------------
F
D
L
G
G
------------------
H
I
Q
--
A
R
R
L
W
K
----
D
Y
F
P
E
V
N
G
I
V
F
L
V
------
D
A
A
------
D
P
E
R
F
D
E
A
R
V
E
L
D
A
L
F
N
I
---------------------------------------------------------
A
E
L
K
D
V
--
P
F
V
I
-
L
G
N
K
I
D
---
A
P
N
---
A
---
V
-----
S
----
E
---
A
E
----
L
R
S
A
L
GLLNTTGIEG
Q
-
R
---
P
-
V
E
V
F
M
C
S
V
V
M
R
N
G
Y
L
E
A
F
Q
W
L
S
----
Q
Y
I
--------------------------------------------------------------------------------------------------------
35
HHSearch
48.12
24%
-87
- C2 -
1WF3
4
ERA_THET8
A:
[7-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
F
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
-----
N
N
L
L
G
V
K
V
A
P
-
I
S
P
R
P
Q
T
T
R
K
R
L
R
--
G
I
L
T
E
G
-
R
--------------------
R
Q
I
V
F
--------------------
V
D
T
P
G
L
H
--------
K
P
M
D
A
L
--
G
E
F
--
M
D
Q
E
V
Y
----
E
A
L
A
D
V
N
A
V
V
W
V
V
------
D
L
R
H
---
P
P
T
P
E
D
-
E
L
V
A
R
A
L
K
P
L
--
V
------------------------------------------------------------
G
K
V
--
P
I
L
L
-
V
G
N
K
L
D
---
A
A
K
---
Y
---
P
E
----
E
----
A
M
--
K
A
----
Y
H
E
L
-----------
L
-
P
---
E
-
A
E
P
R
M
L
S
A
L
D
E
R
Q
V
A
E
L
K
A
D
L
L
----
A
L
M
-
P
E
G
P
---------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
33.80
35%
-76
- C2 -
2DBY
3
?
A:
[4-145]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
I
V
G
L
P
N
V
G
K
S
T
L
F
-----
N
A
L
T
R
A
N
A
-
L
-
A
A
N
Y
P
F
A
T
I
D
K
N
V
--
G
V
V
P
L
E
D
E
--------------------
R
L
Y
A
L
Q
R
T
F
AKGE
R
V
P
P
V
V
P
T
H
V
E
F
V
D
I
A
G
L
V
--------
K
G
A
H
K
---
G
E
G
--
L
G
N
Q
F
L
----
A
H
I
R
E
V
A
A
I
A
H
V
L
R
CFPD
P
----------
L
E
D
A
E
V
V
E
T
E
L
L
L
A
--
D
---------------------------------------------------------
L
A
T
L
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------