@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1538: (2016-03-25 )
MEKKYILALDQGTTSSRAMIIDEEGEVIGVAQEEFDQIFPKPGWVEHNANEIWASILAVIAGVLLKTNISSKEIAGIGITNQRETTVIWDKESGNPIYNAIVWQSRQTEDICKQLRKDGYEDTIRSKTGLLIDPYFAGTKARWILDHVDGAQERAEKGELLFGTIDTWLVWKLTGGRAHITDYSNASRTLLYNIYDLEWDDELLKMLNIPKAMLPEVRPSSEVYADTVPYHFFGEEVPVAGIAGDQQAALFGQGCFEKGMAKNTYGTGCFLLMNTGEKAVRSENGLLTTLAWGIDGKVEYALEGSIFVAGSAIQWLRDGLRMVRQSSDSENYASRIESSDGVYVVPAFVGLGAPYWDSDVRGAVFGLTRGTEKEQFIRATLESLAYQTRDVLYAMEQDSGISLKTLRVDGGASANNFLMQFQSDILGVPVERPENKETTVLGAAFLAGLAVGVWKDKNEIKKHWKLDKRFEVEMKEEQREDLYEGWHKAVKAAQAFK
Atome Classification :
(40 SA)
.........10........20........30........40........50........60-..-......70........80........90........100.......110.......120.......130.......140.......150.......160.......170.....---..180.......190.......200.......210........220----.......230.......240.......250.......260.......270.......280.......290..--.-....300.......310.......320..-.....330.......340.......350.......360.......370.......380.......390.......400-.......410.......420.......430.......440.......450.......460....-...470.......480.......490.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEK
K
Y
I
L
A
LDQGTTSS
R
A
M
I
IDEEG
E
V
I
G
V
A
Q
E
E
F
D
Q
IFPKPGWVEH
N
A
N
E
I
W
A
S
I
L
A
V
I
A
-
G
V
-
L
L
KTNISSK
E
I
A
G
I
GITNQR
E
T
T
V
I
W
DKESGNP
I
Y
N
A
I
VWQSR
Q
T
E
D
I
C
K
Q
L
R
KDGY
E
D
T
I
RSKT
G
L
L
IDPYFAGT
K
A
R
W
I
L
DHVD
G
A
Q
E
R
A
EKG
E
L
L
F
G
TID
T
W
L
V
W
K
LTGG
R
---
A
H
I
TDYSNA
S
R
T
L
L
Y
N
I
YDLEW
D
D
E
L
L
K
M
LNI
P
K
-
A
MLPEVRPSSE----VYADTV
P
Y
H
FFGEEVPVAGIAGD
Q
Q
A
A
L
F
G
Q
G
C
F
EKGMAKNTYG
T
G
C
F
L
L
MNTG
E
K
A
VRSEN
G
L
L
T
T
L
A
WGI--D-G
K
V
E
Y
A
LEG
S
I
F
V
A
G
S
A
I
Q
W
L
R
D
G
L
R
M
V
R
-QSSDS
E
N
Y
A
S
RIESSD
G
V
Y
V
V
P
A
F
VGLGAPYWDSDVRG
A
V
F
GLTRGT
E
K
E
Q
F
I
R
A
T
L
E
S
L
A
Y
Q
T
R
D
V
L
Y
A
MEQDSG
I
S
-
L
K
T
L
R
VDGGAS
A
N
N
F
L
M
Q
F
Q
S
DILGVPVERPENKETT
V
L
G
A
A
F
L
A
G
L
A
VGVWK
D
K
N
E
I
K
K
H
WKL-DK
R
F
E
V
E
M
K
E
E
Q
R
E
D
L
Y
E
G
W
H
K
A
V
K
A
A
QAFK
73
HHSearch
97.94
70%
-85
- C1 -
3G25
9
GLPK_STAAC
A:
[3-498]
A
M
E
K
Y
I
L
S
I
D
Q
G
T
T
S
S
R
A
I
L
F
N
Q
K
G
E
I
A
G
V
A
Q
R
E
F
K
Q
Y
F
P
Q
S
G
W
V
E
H
D
A
N
E
I
W
T
S
V
L
A
V
M
T
-
E
V
-
I
N
E
N
D
V
R
A
D
Q
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
H
T
G
R
P
I
Y
H
A
I
V
W
Q
S
R
Q
T
Q
S
I
C
S
E
L
K
Q
Q
G
Y
E
Q
T
F
R
D
K
T
G
L
L
L
D
P
Y
F
A
G
T
K
V
K
W
I
L
D
N
V
E
G
A
R
E
K
A
E
N
G
D
L
L
F
G
T
I
D
T
W
L
V
W
K
L
S
G
K
A
---
A
H
I
T
D
Y
S
N
A
S
R
T
L
M
F
N
I
H
D
L
E
W
D
D
E
L
L
E
L
L
T
V
P
K
-
N
M
L
P
E
V
K
A
S
S
E
----
V
Y
G
K
T
I
D
Y
H
F
Y
G
Q
E
V
P
I
A
G
V
A
G
D
Q
Q
A
A
L
F
G
Q
A
C
F
E
R
G
D
V
K
N
T
Y
G
T
G
G
F
M
L
M
N
T
G
D
K
A
V
K
S
E
S
G
L
L
T
T
I
A
Y
G
I
--
D
-
G
K
V
N
Y
A
L
E
G
S
I
F
V
S
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
N
-
S
A
P
Q
S
E
S
Y
A
T
R
V
D
S
T
E
G
V
Y
V
V
P
A
F
V
G
L
G
T
P
Y
W
D
S
E
A
R
G
A
I
F
G
L
T
R
G
T
E
K
E
H
F
I
R
A
T
L
E
S
L
C
Y
Q
T
R
D
V
M
E
A
M
S
K
D
S
G
I
D
-
V
Q
S
L
R
V
D
G
G
A
V
K
N
N
F
I
M
Q
F
Q
A
D
I
V
N
T
S
V
E
R
P
E
I
Q
E
T
T
A
L
G
A
A
F
L
A
G
L
A
V
G
F
W
E
S
K
D
D
I
A
K
N
W
K
L
-
E
E
K
F
D
P
K
M
D
E
G
E
R
E
K
L
Y
R
G
W
K
K
A
V
E
A
T
Q
V
F
-
1
PsiBlast_PDB
97.15
68%
-85
- C1 -
3G25
9
GLPK_STAAC
A:
[5-499]
--
E
K
Y
I
L
S
I
D
Q
G
T
T
S
S
R
A
I
L
F
N
Q
K
G
E
I
A
G
V
A
Q
R
E
F
K
Q
Y
F
P
Q
S
G
W
V
E
H
D
A
N
E
I
W
T
S
V
L
A
V
M
T
-
E
V
-
I
N
E
N
D
V
R
A
D
Q
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
H
T
G
R
P
I
Y
H
A
I
V
W
Q
S
R
Q
T
Q
S
I
C
S
E
L
K
Q
Q
G
Y
E
Q
T
F
R
D
K
T
G
L
L
L
D
P
Y
F
A
G
T
K
V
K
W
I
L
D
N
V
E
G
A
R
E
K
A
E
N
G
D
L
L
F
G
T
I
D
T
W
L
V
W
K
L
S
G
K
A
---
A
H
I
T
D
Y
S
N
A
S
R
T
L
M
F
N
I
H
D
L
E
W
D
D
E
L
L
E
L
L
T
V
P
K
-
N
M
L
P
E
V
K
A
S
S
E
----
V
Y
G
K
T
I
D
Y
H
F
Y
G
Q
E
V
P
I
A
G
V
A
G
D
Q
Q
A
A
L
F
G
Q
A
C
F
E
R
G
D
V
K
N
T
Y
G
T
G
G
F
M
L
M
N
T
G
D
K
A
V
K
S
E
S
G
L
L
T
T
I
A
Y
G
I
--
D
-
G
K
V
N
Y
A
L
E
G
S
I
F
V
S
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
N
-
S
A
P
Q
S
E
S
Y
A
T
R
V
D
S
T
E
G
V
Y
V
V
P
A
F
V
G
L
G
T
P
Y
W
D
S
E
A
R
G
A
I
F
G
L
T
R
G
T
E
K
E
H
F
I
R
A
T
L
E
S
L
C
Y
Q
T
R
D
V
M
E
A
M
S
K
D
S
G
I
D
-
V
Q
S
L
R
V
D
G
G
A
V
K
N
N
F
I
M
Q
F
Q
A
D
I
V
N
T
S
V
E
R
P
E
I
Q
E
T
T
A
L
G
A
A
F
L
A
G
L
A
V
G
F
W
E
S
K
D
D
I
A
K
N
W
K
L
-
E
E
K
F
D
P
K
M
D
E
G
E
R
E
K
L
Y
R
G
W
K
K
A
V
E
A
T
Q
V
F
K
36
PsiBlast_CBE
96.58
64%
-80
- C1 -
3H46
3
GLPK_ENTCA
O:
[3-498]
-
E
K
N
Y
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
P
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
W
N
S
V
Q
S
V
I
A
-
G
A
-
F
I
E
S
G
I
R
P
E
A
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
F
G
T
I
D
S
W
L
V
W
K
L
T
D
G
Q
---
V
H
V
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
S
-
S
M
L
P
E
V
K
S
N
S
E
----
V
Y
G
H
T
R
S
Y
E
F
Y
G
S
E
V
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
-
G
K
V
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
E
-
T
S
P
Q
S
E
E
L
A
A
K
A
K
G
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
K
K
D
S
G
I
D
-
I
P
L
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
G
L
A
V
G
F
W
K
D
L
D
E
L
K
S
M
A
E
E
-
G
Q
M
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
16
PsiBlast_PDB
96.58
64%
-80
- C1 -
3H46
3
GLPK_ENTCA
X:
[3-498]
-
E
K
N
Y
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
P
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
W
N
S
V
Q
S
V
I
A
-
G
A
-
F
I
E
S
G
I
R
P
E
A
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
F
G
T
I
D
S
W
L
V
W
K
L
T
D
G
Q
---
V
H
V
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
S
-
S
M
L
P
E
V
K
S
N
S
E
----
V
Y
G
H
T
R
S
Y
E
F
Y
G
S
E
V
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
-
G
K
V
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
E
-
T
S
P
Q
S
E
E
L
A
A
K
A
K
G
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
K
K
D
S
G
I
D
-
I
P
L
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
G
L
A
V
G
F
W
K
D
L
D
E
L
K
S
M
A
E
E
-
G
Q
M
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
43
PsiBlast_CBE
96.50
64%
-79
- C1 -
3H3N
6
GLPK_ENTCA
O:
[3-498]
-
E
K
N
Y
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
P
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
W
N
S
V
Q
S
V
I
A
-
G
A
-
F
I
E
S
G
I
R
P
E
A
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
F
G
T
I
D
S
W
L
V
W
K
L
T
D
G
Q
---
V
H
V
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
S
-
S
M
L
P
E
V
K
S
N
S
E
----
V
Y
G
H
T
R
S
Y
R
F
Y
G
S
E
V
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
-
G
K
V
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
E
-
T
S
P
Q
S
E
E
L
A
A
K
A
K
G
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
K
K
D
S
G
I
D
-
I
P
L
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
G
L
A
V
G
F
W
K
D
L
D
E
L
K
S
M
A
E
E
-
G
Q
M
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
39
PsiBlast_CBE
96.49
64%
-83
- C1 -
3H45
2
GLPK_ENTCA
C:
[3-498]
-
E
K
N
Y
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
P
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
W
N
S
V
Q
S
V
I
A
-
G
A
-
F
I
E
S
G
I
R
P
E
A
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
F
G
T
I
D
S
W
L
V
W
K
L
T
D
G
Q
---
V
H
V
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
S
-
S
M
L
P
E
V
K
S
N
S
E
----
V
Y
G
H
T
R
S
Y
E
F
Y
G
S
E
V
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
-
G
K
V
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
E
-
T
S
P
Q
S
E
E
L
A
A
K
A
K
G
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
K
K
D
S
G
I
D
-
I
P
L
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
G
L
A
V
G
F
W
K
D
L
D
E
L
K
S
M
A
E
E
-
G
Q
M
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
15
PsiBlast_PDB
96.49
64%
-83
- C1 -
3H45
5
GLPK_ENTCA
X:
[3-498]
-
E
K
N
Y
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
P
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
W
N
S
V
Q
S
V
I
A
-
G
A
-
F
I
E
S
G
I
R
P
E
A
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
F
G
T
I
D
S
W
L
V
W
K
L
T
D
G
Q
---
V
H
V
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
S
-
S
M
L
P
E
V
K
S
N
S
E
----
V
Y
G
H
T
R
S
Y
E
F
Y
G
S
E
V
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
-
G
K
V
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
E
-
T
S
P
Q
S
E
E
L
A
A
K
A
K
G
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
K
K
D
S
G
I
D
-
I
P
L
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
G
L
A
V
G
F
W
K
D
L
D
E
L
K
S
M
A
E
E
-
G
Q
M
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
42
PsiBlast_CBE
96.36
64%
-81
- C1 -
3H3O
4
GLPK_ENTCA
B:
[3-498]
-
E
K
N
Y
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
P
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
W
N
S
V
Q
S
V
I
A
-
G
A
-
F
I
E
S
G
I
R
P
E
A
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
F
G
T
I
D
S
W
L
V
W
K
L
T
D
G
Q
---
V
H
V
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
S
-
S
M
L
P
E
V
K
S
N
S
E
----
V
Y
G
H
T
R
S
Y
R
F
Y
G
S
E
V
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
-
G
K
V
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
E
-
T
S
P
Q
S
E
E
L
A
A
K
A
K
G
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
K
K
D
S
G
I
D
-
I
P
L
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
G
L
A
V
G
F
W
K
D
L
D
E
L
K
S
M
A
E
E
-
G
Q
M
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
40
PsiBlast_CBE
96.36
64%
-81
- C1 -
3H3O
7
GLPK_ENTCA
X:
[3-498]
-
E
K
N
Y
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
P
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
W
N
S
V
Q
S
V
I
A
-
G
A
-
F
I
E
S
G
I
R
P
E
A
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
F
G
T
I
D
S
W
L
V
W
K
L
T
D
G
Q
---
V
H
V
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
S
-
S
M
L
P
E
V
K
S
N
S
E
----
V
Y
G
H
T
R
S
Y
R
F
Y
G
S
E
V
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
-
G
K
V
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
E
-
T
S
P
Q
S
E
E
L
A
A
K
A
K
G
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
K
K
D
S
G
I
D
-
I
P
L
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
G
L
A
V
G
F
W
K
D
L
D
E
L
K
S
M
A
E
E
-
G
Q
M
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K
77
HHSearch
96.25
64%
-79
- C1 -
3H3N
5
GLPK_ENTCA
X:
[2-497]
A
E
K
N
Y
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
P
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
W
N
S
V
Q
S
V
I
A
-
G
A
-
F
I
E
S
G
I
R
P
E
A
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
F
G
T
I
D
S
W
L
V
W
K
L
T
D
G
Q
---
V
H
V
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
S
-
S
M
L
P
E
V
K
S
N
S
E
----
V
Y
G
H
T
R
S
Y
R
F
Y
G
S
E
V
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
-
G
K
V
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
E
-
T
S
P
Q
S
E
E
L
A
A
K
A
K
G
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
K
K
D
S
G
I
D
-
I
P
L
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
G
L
A
V
G
F
W
K
D
L
D
E
L
K
S
M
A
E
E
-
G
Q
M
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
-
2
PsiBlast_PDB
96.18
68%
-83
- C1 -
3GE1
6
GLPK_STAAC
A:
[5-499]
--
E
K
Y
I
L
S
I
D
Q
G
T
T
S
S
R
A
I
L
F
N
Q
K
G
E
I
A
G
V
A
Q
R
E
F
K
Q
Y
F
P
Q
S
G
W
V
E
H
D
A
N
E
I
W
T
S
V
L
A
V
M
T
-
E
V
-
I
N
E
N
D
V
R
A
D
Q
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
H
T
G
R
P
I
Y
H
A
I
V
W
Q
S
R
Q
T
Q
S
I
C
S
E
L
K
Q
Q
G
Y
E
Q
T
F
R
D
K
T
G
L
L
L
D
P
Y
F
A
G
T
K
V
K
W
I
L
D
N
V
E
G
A
R
E
K
A
E
N
G
D
L
L
F
G
T
I
D
T
W
L
V
W
K
L
S
G
K
A
---
A
H
I
T
D
Y
S
N
A
S
R
T
L
M
F
N
I
H
D
L
E
W
D
D
E
L
L
E
L
L
T
V
P
K
-
N
M
L
P
E
V
K
A
S
S
E
----
V
Y
G
K
T
I
D
Y
H
F
Y
G
Q
E
V
P
I
A
G
V
A
G
D
Q
Q
A
A
L
F
G
Q
A
C
F
E
R
G
D
V
K
N
T
Y
G
T
G
G
F
M
L
M
N
T
G
D
K
A
V
K
S
E
S
G
L
L
T
T
I
A
Y
G
I
--
D
-
G
K
V
N
Y
A
L
E
G
S
I
F
V
S
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
N
-
S
A
P
Q
S
E
S
Y
A
T
R
V
D
S
T
E
G
V
Y
V
V
P
A
F
V
G
L
G
T
P
Y
W
D
S
E
A
R
G
A
I
F
G
L
T
R
G
T
E
K
E
H
F
I
R
A
T
L
E
S
L
C
Y
Q
T
R
D
V
M
E
A
M
S
K
D
S
G
I
D
-
V
Q
S
L
R
V
D
G
G
A
V
K
N
N
F
I
M
Q
F
Q
A
D
I
V
N
T
S
V
E
R
P
E
I
Q
E
T
T
A
L
G
A
A
F
L
A
G
L
A
V
G
F
W
E
S
K
D
D
I
A
K
N
W
K
L
-
E
E
K
F
D
P
K
M
D
E
G
E
R
E
K
L
Y
R
G
W
K
K
A
V
E
A
T
Q
V
F
K
37
PsiBlast_CBE
95.94
64%
-81
- C1 -
3H45
3
GLPK_ENTCA
O:
[3-498]
-
E
K
N
Y
V
M
A
I
D
Q
G
T
T
S
S
R
A
I
I
F
D
R
N
G
K
K
I
G
S
S
Q
K
E
F
P
Q
Y
F
P
K
S
G
W
V
E
H
N
A
N
E
I
W
N
S
V
Q
S
V
I
A
-
G
A
-
F
I
E
S
G
I
R
P
E
A
I
A
G
I
G
I
T
N
Q
R
E
T
T
V
V
W
D
K
T
T
G
Q
P
I
A
N
A
I
V
W
Q
S
R
Q
S
S
P
I
A
D
Q
L
K
V
D
G
H
T
E
M
I
H
E
K
T
G
L
V
I
D
A
Y
F
S
A
T
K
V
R
W
L
L
D
N
I
E
G
A
Q
E
K
A
D
N
G
E
L
L
F
G
T
I
D
S
W
L
V
W
K
L
T
D
G
Q
---
V
H
V
T
D
Y
S
N
A
S
R
T
M
L
Y
N
I
H
K
L
E
W
D
Q
E
I
L
D
L
L
N
I
P
S
-
S
M
L
P
E
V
K
S
N
S
E
----
V
Y
G
H
T
R
S
Y
E
F
Y
G
S
E
V
P
I
A
G
M
A
G
D
Q
Q
A
A
L
F
G
Q
M
A
F
E
K
G
M
I
K
N
T
Y
G
T
G
A
F
I
V
M
N
T
G
E
E
P
Q
L
S
D
N
D
L
L
T
T
I
G
Y
G
I
--
N
-
G
K
V
Y
Y
A
L
E
G
S
I
F
V
A
G
S
A
I
Q
W
L
R
D
G
L
R
M
I
E
-
T
S
P
Q
S
E
E
L
A
A
K
A
K
G
D
N
E
V
Y
V
V
P
A
F
T
G
L
G
A
P
Y
W
D
S
E
A
R
G
A
V
F
G
L
T
R
G
T
T
K
E
D
F
V
R
A
T
L
Q
A
V
A
Y
Q
S
K
D
V
I
D
T
M
K
K
D
S
G
I
D
-
I
P
L
L
K
V
D
G
G
A
A
K
N
D
L
L
M
Q
F
Q
A
D
I
L
D
I
D
V
Q
R
A
A
N
L
E
T
T
A
L
G
A
A
Y
L
A
G
L
A
V
G
F
W
K
D
L
D
E
L
K
S
M
A
E
E
-
G
Q
M
F
T
P
E
M
P
A
E
E
R
D
N
L
Y
E
G
W
K
Q
A
V
A
A
T
Q
T
F
K