@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1553: (2016-03-26 )
LQNYSKSEKAFKEAKKVLPGGVNSPVRAFNSVDASPVFMDHGKGAYITDVDGNEYIDYVLSWGPLILGHTDPAVVNAITKAALKGTSFGTPTEIETELAKLVIERVPSIEIVRMVSSGTEATMSAIRLARGYTKREKILKFEGSYHGHGDSLLIKAGSGVATLGLPDSPGVTKGLAADTITVPYNDIEGAKLAFEKYGEEIAAVIVEPVAGNMGVVPPIEGFLEGLRELTTKFGSLLIFDEVMTGFRVDYYSAQGYYVVTPDLTCLGKVIGGGLPVGAYGGKKEIMEQIAPAGSIYQAGTLSGNPLAMNAGFETVRQLTPQHYDVFRTLIKRMEEGLTEISARRQVPLSINKAGSMFGFFFTDQKVINFDTAKTSNLEFFRNYYREMLGQGIFLPPSQFEGVFISTMHTENEIDKTLEAFDTTCKILRG
Atome Classification :
(52 SA)
.........10........20.....---...30........40........50........60........70........80.--.......90........100.......110..--.....120.......130..------.....140.......150.......160.......170..---..---...180.......190.......200.......210.......220.......230.......240....-...250.......260.......270.......280.....--..290--.......300......---.310......--.-320.-.......330.......340....---...350........360.......370.......380.......390.......400.......410.......420.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LQNY
S
K
S
E
K
A
F
K
E
A
K
K
VLPGGVN
S
P
V
---
R
A
FNSVDAS
P
V
F
MDHGK
G
A
Y
I
T
DVDG
N
E
Y
I
D
Y
V
LSWG
P
L
I
LGHT
D
P
A
V
V
N
A
I
T
K
A
A--LKGTSFGT
P
T
E
I
E
T
E
L
A
K
L
V
I
E
RVP
S
I
E
I
V
R
M
--VSSG
T
E
A
T
M
S
A
I
R
L
ARGY
T
K
------
R
E
K
I
L
K
FEGSYHGHG
D
S
L
L
I
KAGS
G
V
A
T
LGLPDSPGVTKG---LA---A
D
T
I
T
V
PYNDIE
G
A
K
L
A
F
E
K
Y
G
E
E
I
A
A
V
I
VEPVAGNMGVVP
P
I
E
G
F
L
E
G
L
R
E
L
T
T
K
FG
S
L
L
I
F
D
E
V
M
TG
F
-
R
V
D
Y
Y
SAQ
G
Y
Y
V
VT
P
D
L
T
C
L
G
K
V
IGGGLPVGAYG
G
K
K
E
I
M
E
--
Q
IAPA--GS
I
Y
Q
AGTLSGN
P
L
A
M---N
A
G
F
E
T
V
R
Q
L--
T
-
P
-
Q
H
-
Y
D
V
F
R
T
L
I
K
R
M
E
E
G
L
T
E
I
S
ARRQV---
P
L
S
IN-KAG
S
M
F
G
F
F
FTD
Q
K
V
I
N
FDTAKTS
N
L
E
F
F
R
N
Y
Y
R
E
M
LGQGIFLPPSQFE
G
V
F
I
S
T
MHT
E
N
E
I
D
K
T
L
E
A
F
D
T
T
C
K
ILRG
1
PsiBlast_PDB
97.15
71%
-92
- C2 -
3BS8
1
GSA_BACSU
A:
[9-427]
M
R
S
Y
E
K
S
K
T
A
F
K
E
A
Q
K
L
M
P
G
G
V
N
S
P
V
---
R
A
F
K
S
V
D
M
D
P
I
F
M
E
R
G
K
G
S
K
I
F
D
I
D
G
N
E
Y
I
D
Y
V
L
S
W
G
P
L
I
L
G
H
T
N
D
R
V
V
E
S
L
K
K
V
A
--
E
Y
G
T
S
F
G
A
P
T
E
V
E
N
E
L
A
K
L
V
I
D
R
V
P
S
V
E
I
V
R
M
--
V
S
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
N
K
I
L
K
F
E
G
C
Y
H
G
H
G
D
S
L
L
I
K
A
G
S
G
V
A
T
L
G
L
P
D
S
P
G
V
P
E
G
---
I
A
---
K
N
T
I
T
V
P
Y
N
D
L
E
S
V
K
L
A
F
Q
Q
F
G
E
D
I
A
G
V
I
V
E
P
V
A
G
N
M
G
V
V
P
P
Q
E
G
F
L
Q
G
L
R
D
I
T
E
Q
Y
G
S
L
L
I
F
D
E
V
M
T
G
F
-
R
V
D
Y
N
C
A
Q
G
Y
F
G
V
T
P
D
L
T
C
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
K
A
E
I
M
E
--
Q
I
A
P
S
--
G
P
I
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
L
E
T
L
K
Q
L
--
T
-
P
-
D
S
-
Y
K
N
F
I
K
K
G
D
R
L
E
E
G
I
S
K
A
A
E
A
H
G
I
---
P
H
T
F
N
-
R
A
G
S
M
I
G
F
F
F
T
N
E
P
V
I
N
Y
E
T
A
K
A
S
D
L
K
L
F
A
S
Y
Y
K
G
M
A
N
E
G
V
F
L
P
P
S
Q
F
E
G
L
F
L
S
T
A
H
T
D
E
D
I
E
N
T
I
Q
A
----------
8
PsiBlast_PDB
88.03
55%
-91
- C2 -
2HOZ
3
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
4
PsiBlast_PDB
86.77
55%
-88
- C2 -
3GSB
3
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
9
PsiBlast_PDB
86.73
55%
-88
- C2 -
2HP1
3
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
25
PsiBlast_CBE
86.61
55%
-87
- C2 -
3FQ7
2
GSA_SYNP6
B:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
11
PsiBlast_PDB
86.54
55%
-89
- C2 -
3FQA
3
GSA_SYNP6
A:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
21
PsiBlast_CBE
86.50
55%
-86
* C2 *
4GSA
2
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
13
PsiBlast_PDB
86.42
55%
-88
- C2 -
3FQ8
2
GSA_SYNP6
A:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
3
PsiBlast_PDB
86.33
55%
-86
- C2 -
4GSA
2
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
23
PsiBlast_CBE
86.28
55%
-87
- C2 -
2GSA
2
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
5
PsiBlast_PDB
86.27
55%
-88
- C2 -
3FQ7
2
GSA_SYNP6
A:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
104
HHSearch
86.20
55%
-87
- C2 -
3FQ8
2
GSA_SYNP6
A:
[3-426]
---
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
--
R
Q
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
---
6
PsiBlast_PDB
86.11
55%
-87
- C2 -
3USF
3
GSA_SYNE7
A:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
31
PsiBlast_CBE
85.81
55%
-88
- C2 -
3FQ8
2
GSA_SYNP6
B:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
28
PsiBlast_CBE
85.77
55%
-90
- C2 -
2HOZ
2
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
-------
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
2
PsiBlast_PDB
85.42
55%
-85
- C2 -
2GSA
2
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
30
PsiBlast_CBE
85.36
55%
-87
- C2 -
3FQA
3
GSA_SYNP6
B:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
10
PsiBlast_PDB
85.20
55%
-91
- C2 -
2HP2
3
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
29
PsiBlast_CBE
85.10
55%
-95
- C2 -
2HOY
2
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
----------------------------------------
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
125
Fugue
84.78
55%
-83
- C2 -
2GSA
2
GSA_SYNP6
A:
[6-432]
-
F
K
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
--
R
Q
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
26
PsiBlast_CBE
84.75
55%
-87
- C2 -
2HP2
3
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
27
PsiBlast_CBE
84.36
55%
-93
- C2 -
2HP1
3
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
-----------------------------------
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
22
PsiBlast_CBE
84.21
55%
-86
- C2 -
3GSB
3
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
103
HHSearch
83.73
50%
-83
- C2 -
2E7U
4
GSA_THET8
A:
[2-424]
--
E
R
P
I
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
---
R
A
F
K
A
V
G
G
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
--
E
R
G
L
T
F
G
A
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
--
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
V
P
S
S
A
G
V
P
E
E
---
Y
A
---
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
A
L
H
E
-
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
--
K
V
A
P
L
--
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
A
A
G
L
A
T
L
E
L
L
--
E
E
N
P
G
Y
-
Y
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
---
P
H
T
V
N
-
R
V
G
S
M
I
T
V
F
F
T
E
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
L
-----
14
PsiBlast_PDB
83.24
50%
-85
- C2 -
2E7U
4
GSA_THET8
A:
[6-420]
------
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
---
R
A
F
K
A
V
G
G
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
--
E
R
G
L
T
F
G
A
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
--
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
V
P
S
S
A
G
V
P
E
E
---
Y
A
---
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
A
L
H
E
-
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
--
K
V
A
P
L
--
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
A
A
G
L
A
T
L
E
L
L
E
E
N
-
P
-
G
Y
-
Y
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
---
P
H
T
V
N
-
R
V
G
S
M
I
T
V
F
F
T
E
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
---------
33
PsiBlast_CBE
82.86
42%
-89
- C2 -
2ZSM
4
GSA_AERPE
B:
[10-433]
----
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
--
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
--
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
---
V
A
---
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
---
A
A
G
L
A
T
L
K
A
L
--
E
-
E
-
E
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
---
P
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
G
24
PsiBlast_CBE
82.29
55%
-94
- C2 -
3USF
3
GSA_SYNE7
B:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
---
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
--
E
K
G
T
S
F
G
A
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
----------------------------
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
A
--
G
P
M
Y
Q
A
G
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
L
L
R
-
Q
-
P
-
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
---
A
A
C
G
G
-
Q
V
S
G
M
F
G
F
F
F
T
E
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
--
32
PsiBlast_CBE
82.00
42%
-87
- C2 -
2ZSM
4
GSA_AERPE
C:
[10-433]
----
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
--
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
--
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
---
V
A
---
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
---
A
A
G
L
A
T
L
K
A
L
--
E
-
E
-
E
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
---
P
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
G
15
PsiBlast_PDB
81.97
42%
-86
- C2 -
2EPJ
1
GSA_AERPE
A:
[9-433]
---
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
--
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
--
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
---
V
A
---
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
---
A
A
G
L
A
T
L
K
A
L
--
E
-
E
-
E
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
---
P
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
G
16
PsiBlast_PDB
81.86
42%
-86
- C2 -
2ZSL
1
GSA_AERPE
A:
[9-433]
---
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
--
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
--
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
---
V
A
---
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
---
A
A
G
L
A
T
L
K
A
L
--
E
-
E
-
E
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
---
P
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
G
17
PsiBlast_PDB
81.82
42%
-84
- C2 -
2ZSM
2
GSA_AERPE
A:
[6-433]
L
A
S
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
--
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
--
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
---
V
A
---
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
---
A
A
G
L
A
T
L
K
A
L
--
E
-
E
-
E
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
---
P
Y
T
I
N
-
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
G
12
PsiBlast_PDB
79.94
56%
-98
- C2 -
2CFB
1
GSA_THEEB
A:
[19-411]
--------------------------------------
P
I
V
F
D
H
V
K
G
A
H
I
W
D
V
D
G
N
Q
Y
I
D
Y
V
G
S
W
G
P
A
I
V
G
H
A
H
P
E
V
I
D
A
L
H
A
A
L
--
E
K
G
T
S
F
G
A
P
C
L
L
E
N
I
L
A
E
M
V
I
A
A
V
P
S
V
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
Q
------
R
E
K
V
I
K
F
E
G
C
Y
H
G
H
A
----------------------------------
A
T
L
T
A
P
Y
N
D
L
E
A
V
S
R
L
F
E
Q
Y
P
N
D
I
A
G
V
I
L
E
P
V
V
G
N
A
G
F
I
P
P
D
A
G
F
L
E
G
L
R
E
L
T
K
Q
Y
G
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
A
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
R
A
E
I
M
K
--
M
V
A
P
A
--
G
P
-----
T
L
S
G
N
P
L
A
M
---
T
A
G
I
K
T
L
E
I
L
--
S
R
P
-
G
S
-
Y
E
H
L
D
R
I
T
G
K
L
V
Q
G
L
L
D
A
A
R
E
F
G
H
---
E
V
C
G
G
-
H
I
S
G
M
F
G
L
F
F
T
A
G
P
V
T
N
Y
E
Q
A
K
Q
S
D
L
K
K
F
A
A
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
A
D
I
E
R
T
I
A
A
A
R
T
V
L
S
Q
L
--
109
HHSearch
74.48
41%
-77
- C2 -
2EPJ
1
GSA_AERPE
A:
[9-432]
---
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
---
R
A
A
V
--
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
--
A
R
G
W
L
Y
G
A
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
--
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
---
V
A
---
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
Q
--
G
K
V
F
N
A
G
T
F
N
A
H
P
I
T
M
---
A
A
G
L
A
T
L
K
A
L
--
E
E
E
-
P
V
-
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
T
I
N
R
V
E
S
M
M
Q
L
F
I
G
V
E
E
V
S
N
A
A
Q
----
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
G
L
R
S
S
L
K
T
V
L
-
40
PsiBlast_CBE
62.69
33%
-74
- C2 -
2YKX
6
?
C:
[62-431]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
--
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
P
T
N
A
P
Y
H
--
V
V
L
G
---
V
-----------
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
---
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
-
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
---
P
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
---------------------------------
41
PsiBlast_CBE
62.38
33%
-75
- C2 -
2YKX
5
?
B:
[62-431]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
--
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
P
T
N
A
P
Y
H
--
V
V
L
G
---
V
-----------
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
---
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
-
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
---
P
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
---------------------------------
37
PsiBlast_CBE
62.31
33%
-75
- C2 -
2YKY
11
?
C:
[62-431]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
--
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
P
T
N
A
P
Y
H
--
V
V
L
G
---
V
-----------
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
---
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
-
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
---
P
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
---------------------------------
45
PsiBlast_CBE
61.38
33%
-74
- C2 -
2YKU
10
?
B:
[62-431]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
--
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
P
T
N
A
P
Y
H
--
V
V
L
G
---
V
-----------
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
---
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
-
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
---
P
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
---------------------------------
38
PsiBlast_CBE
60.68
33%
-74
- C2 -
2YKY
16
?
B:
[62-431]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
--
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
P
T
N
A
P
Y
H
--
V
V
L
G
---
V
-----------
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
---
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
-
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
---
P
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
---------------------------------
44
PsiBlast_CBE
60.65
33%
-72
- C2 -
2YKU
6
?
C:
[62-431]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
--
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
P
T
N
A
P
Y
H
--
V
V
L
G
---
V
-----------
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
---
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
-
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
---
P
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
---------------------------------
20
PsiBlast_PDB
60.40
33%
-73
- C2 -
2YKX
8
?
A:
[62-431]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
--
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
P
T
N
A
P
Y
H
--
V
V
L
G
---
V
-----------
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
---
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
-
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
---
P
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
---------------------------------
39
PsiBlast_CBE
60.27
33%
-73
- C2 -
2YKY
11
?
A:
[62-431]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
--
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
P
T
N
A
P
Y
H
--
V
V
L
G
---
V
-----------
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
---
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
-
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
---
P
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
---------------------------------
18
PsiBlast_PDB
59.42
33%
-73
- C2 -
2YKU
9
?
A:
[62-431]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
LFH
R
P
F
------
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
--
A
V
G
L
N
L
S
T
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
P
T
N
A
P
Y
H
--
V
V
L
G
---
V
-----------
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
A
RD
G
A
F
A
H
A
G
T
F
N
N
N
I
L
T
M
---
S
A
G
H
A
A
L
T
Q
I
Y-
T
-
R
-
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
---
P
L
Q
F
T
-
G
L
G
S
L
G
T
I
H
F
S
R
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
---------------------------------
67
PsiBlast_CBE
52.24
32%
-77
- C2 -
2PB0
5
ARGD_SALTY
A:
[46-358]
--------------------------------------------
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
--
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
--
S
L
F
--------
T
V
S
V
G
G
Q
P
K
Y
S
D
G
---
F
G
PKP
A
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F-------
G
S
T
Y
-----
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
----
T
-
P
-
E
V
-
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
---
F
S
D
I
R
-
G
M
G
L
L
I
G
-----------------------------------------------------------------------
72
PsiBlast_CBE
52.04
32%
-76
- C2 -
4JEZ
12
ARGD_SALTY
B:
[46-358]
--------------------------------------------
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
R
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
--
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
--
S
L
F
--------
T
V
S
V
G
G
Q
P
K
Y
S
D
G
---
F
G
PKP
A
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F-------
G
S
T
Y
-----
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
----
T
-
P
-
E
V
-
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
---
F
S
D
I
R
-
G
M
G
L
L
I
G
-----------------------------------------------------------------------
65
PsiBlast_CBE
51.52
32%
-77
- C2 -
2PB2
6
ARGD_SALTY
A:
[46-358]
--------------------------------------------
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
--
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
--
S
L
F
--------
T
V
S
V
G
G
Q
P
K
Y
S
D
G
---
F
G
PKP
A
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
----
H
--
G
S
T
Y
-----
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
----
T
-
P
-
E
V
-
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
---
F
S
D
I
R
-
G
M
G
L
L
I
G
-----------------------------------------------------------------------
69
PsiBlast_CBE
51.02
32%
-77
- C2 -
4JF1
9
ARGD_SALTY
A:
[46-358]
--------------------------------------------
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
--
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
--
S
L
F
--------
T
V
S
V
G
G
Q
P
K
Y
S
D
G
---
F
G
PKP
A
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F--------
S
T
Y
-----
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
----
T
-
P
-
E
V
-
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
---
F
S
D
I
R
-
G
M
G
L
L
I
G
-----------------------------------------------------------------------
68
PsiBlast_CBE
50.14
32%
-76
- C2 -
4JF1
9
ARGD_SALTY
B:
[46-358]
--------------------------------------------
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
--
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
--
S
L
F
--------
T
V
S
V
G
G
Q
P
K
Y
S
D
G
---
F
G
PKP
A
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
--
G
S
T
Y
-----
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
----
T
-
P
-
E
V
-
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
---
F
S
D
I
R
-
G
M
G
L
L
I
G
-----------------------------------------------------------------------
66
PsiBlast_CBE
49.44
32%
-75
- C2 -
2PB0
5
ARGD_SALTY
B:
[46-358]
--------------------------------------------
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
--
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
--
S
L
F
--------
T
V
S
V
G
G
Q
P
K
Y
S
D
G
---
F
G
PKP
A
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
AF
H
V
G
S
H
--
G
S
T
Y
-----
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
----
T
-
P
-
E
V
-
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
---
F
S
D
I
R
-
G
M
G
L
L
I
G
-----------------------------------------------------------------------
77
PsiBlast_CBE
49.22
32%
-76
- C2 -
4JEY
13
ARGD_SALTY
A:
[46-358]
--------------------------------------------
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
--
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
--
S
L
F
--------
T
V
S
V
G
G
Q
P
K
Y
S
D
G
---
F
G
PKP
A
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F----
H
--
G
S
T
Y
-----
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
----
T
-
P
-
E
V
-
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
---
F
S
D
I
R
-
G
M
G
L
L
I
G
-----------------------------------------------------------------------
76
PsiBlast_CBE
49.13
32%
-77
- C2 -
4JEY
12
ARGD_SALTY
B:
[46-358]
--------------------------------------------
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
--
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
R
--
S
L
F
--------
T
V
S
V
G
G
Q
P
K
Y
S
D
G
---
F
G
PKP
A
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
--
G
S
T
Y
-----
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
----
T
-
P
-
E
V
-
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
---
F
S
D
I
R
-
G
M
G
L
L
I
G
-----------------------------------------------------------------------
50
PsiBlast_CBE
45.10
34%
-64
- C2 -
1VEF
2
ARGD_THET8
B:
[10-301]
--------
R
A
L
L
E
A
E
K
T
L
D
S
G
V
---------
Y
N
K
H
D
---
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
A
ET
L
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
-
E
L
N
R
V
FP
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
G
------
R
K
K
---
F
V
A
A
M
R
G
F
-------
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
FLP
L
V
---
E
P
V
E
F
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
---
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
--
S
M
P
K
G
--
G
---
H
G
T
T
F
G
G
N
P
L
A
M
---
A
A
G
V
A
A
I
R
Y
L
------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
43.26
34%
-57
- C2 -
1WKG
2
ARGD_THET8
B:
[10-301]
--------
R
A
L
L
E
A
E
K
T
L
D
S
G
V
---------
Y
N
K
H
D
---
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
A
ET
L
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
-
E
L
N
R
V
FP
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
G
------
R
K
K
---
F
V
A
A
M
R
G
F
-------
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
FLP
L
V
---
E
P
V
E
F
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
---
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
--
S
M
P
K
G
--
G
---
H
G
T
T
F
G
G
N
P
L
A
M
---
A
A
G
V
A
A
I
R
Y
L
------------------------------------------------------------------------------------------------------------------------