@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1554: (2016-03-26 )
MKNQFDRHRRLRKTKTMRDLVRETVLHTDDLIYPIFVKDGKEPKTEVVSMPGVFQYPLHELEEEMRVVESLGIKAVILFGIPAEKDAVGTQAYHDHGIIQEATRLIKKSFPKILVVADTCLCEFTDHGHCGVIENGEILNDESLELLKQTAVSQAAAGADIIAPSNMMDGFVQVIREGLDEAGFYDIPIMSYAVKYASAFYGPFRDAAGSAPQFGDRKSYQMDPANREEALREAKSDEQEGADFLIVKPSLSYLDIMRDVKNNTNLPVVAYNVSGEYAMVKAAAQNGWIDEEKIVIEMLTSMKRAGATLIITYFAKDVSKYLNK
Atome Classification :
(36 SA)
.........10........20-........30........40........50........60........70........80--.--.---..--....-.90........100.......110.......120.......130.-.-.-....140.......150.......160.......170.......180..-.-.-...190.......200.......210..--.--....220.......230.......240.......250.......260-.-.-.....270.......280.......290.......300.......310.......320..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKN
Q
F
D
R
H
R
R
L
R
K
T
K
T
M
R
D
L
V
-
R
E
T
VLHTDD
L
I
Y
P
I
F
VKDGKEPKT
E
V
VSMP
G
V
F
QY
P
L
H
E
L
E
E
E
M
R
V
V
E
SLG
I
K
A
V
I
L
F
G---I--P---AE--KDAV-GT
Q
A
YHDH
G
I
I
Q
E
A
T
R
L
I
K
KSFP
K
I
L
V
V
A
DT
C
L
C
EFTDHGHCGVI-E-N-GEIL
N
D
E
S
L
E
L
L
K
Q
T
A
V
S
Q
AAAGADIIAP
S
N
M
M
D
G
F
V
Q
V
I
R
EGLDEAGF-Y-D-I
P
I
M
S
Y
A
V
K
Y
A
S
A
FYGPFRDAAGSAPQF--G--DRKSYQMDPA
N
R
E
E
A
L
R
E
AKSDEQEGA
D
F
L
I
VKPS
L
S
Y
L
D
I
M
R
D
VKN-N-T-NL
P
V
V
A
Y
NVSG
E
Y
A
M
V
K
A
AAQNGWI
D
E
E
K
I
V
I
E
M
L
T
S
M
K
RAG
A
T
L
I
I
T
Y
F
A
K
D
V
S
K
Y
LNK
7
PsiBlast_PDB
95.27
48%
-106
- C5 -
1W5P
11
HEM2_PSEAE
A:
[12-335]
----
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
T-
P
---
V
E
--
K
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
C
L
C
E
F
T
T
H
G
Q
C
G
I
L
-
D
-
D
D
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
D
A
V
-----------
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
-
F
-
R
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
-
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
13
PsiBlast_PDB
94.68
47%
-105
- C5 -
2WOQ
10
HEM2_PSEAE
A:
[12-333]
----
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
T-
P
---
V
E
--
K
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
A
L
D
P
F
T
T
H
G
Q
D
G
I
L
-
D
-
D
D
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
I
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
D
A
V
G
S
A
S
N
L
GK
G
--
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
-
F
-
R
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
-
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
--
48
HHSearch
94.62
52%
-103
* C5 *
1W1Z
2
HEM2_CHLP8
A:
[10-328]
----
V
H
R
P
R
R
L
R
R
T
A
A
L
R
N
L
V
-
Q
E
N
T
L
T
V
N
D
L
V
F
P
L
F
V
M
P
G
T
N
A
V
E
E
V
S
S
M
P
G
S
F
R
F
T
I
D
R
A
V
E
E
C
K
E
L
Y
D
L
G
I
Q
G
I
D
L
F
G
---
I
--
P
---
E
Q
--
K
T
E
D
-
G
S
E
A
Y
N
D
N
G
I
L
Q
Q
A
I
R
A
I
K
K
A
V
P
E
L
C
I
M
T
D
V
A
L
D
P
F
T
P
F
G
H
D
G
L
V
-
K
-
D
-
G
I
I
L
N
D
E
T
V
E
V
L
Q
K
M
A
V
S
H
A
E
A
G
A
D
F
V
S
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
D
E
T
D
H
-
S
-
D
-
V
G
I
L
S
Y
A
A
K
Y
A
S
S
F
Y
G
P
F
R
D
A
L
H
S
A
P
Q
F
--
G
--
D
K
S
T
Y
Q
M
N
P
A
N
T
E
E
A
M
K
E
V
E
L
D
I
V
E
G
A
D
I
V
M
V
K
P
G
L
A
Y
L
D
I
V
W
R
T
K
E
-
R
-
F
-
D
V
P
V
A
I
Y
H
V
S
G
E
Y
A
M
V
K
A
A
A
A
K
G
W
I
D
E
D
R
V
M
M
E
S
L
L
C
M
K
R
A
G
A
D
I
I
F
T
Y
Y
A
K
E
A
A
K
K
L
R
-
10
PsiBlast_PDB
94.12
47%
-105
- C5 -
1W56
4
HEM2_PSEAE
A:
[12-335]
----
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
T-
P
---
V
E
--
K
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
C
L
C
P
F
T
T
H
G
Q
D
G
I
L
-
D
-
D
D
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
D
A
V
G
S
A
S
N
L
GK
G
--
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
-
F
-
R
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
-
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
24
PsiBlast_CBE
94.02
48%
-110
- C5 -
1W5Q
5
HEM2_PSEAE
B:
[12-335]
----
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
T-
P
---
V
E
--
K
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
C
L
C
E
F
T
T
H
G
Q
C
G
I
L
-
D
-
D
D
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
--------------
N
R
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
-
F
-
R
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
-
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
25
PsiBlast_CBE
93.98
48%
-108
- C5 -
1W5P
14
HEM2_PSEAE
B:
[12-335]
----
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
T-
P
---
V
E
--
K
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
C
L
C
E
F
T
T
H
G
Q
C
G
I
L
-
D
-
D
D
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
D
A
V
-----------
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
-
F
-
R
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
-
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
9
PsiBlast_PDB
93.97
47%
-109
- C5 -
1W5N
5
HEM2_PSEAE
A:
[12-335]
----
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
T-
P
---
V
E
--
K
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
A
L
C
P
F
T
T
H
G
Q
C
G
I
L
-
D
-
D
D
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
D
A
V
G
S
---------
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
-
F
-
R
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
-
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
11
PsiBlast_PDB
93.87
47%
-104
- C5 -
1W5M
5
HEM2_PSEAE
A:
[12-335]
----
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
T-
P
---
V
E
--
K
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
C
L
D
P
F
T
T
H
G
Q
C
G
I
L
-
D
-
D
D
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
D
A
V
G
S
A
S
N
L
GK
G
--
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
-
F
-
R
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
-
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
12
PsiBlast_PDB
93.81
47%
-103
- C5 -
1B4K
3
HEM2_PSEAE
A:
[12-335]
----
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
T-
P
---
V
E
--
K
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
A
L
D
P
F
T
T
H
G
Q
D
G
I
L
-
D
-
D
D
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
I
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
D
A
V
G
S
A
S
N
L
GK
G
--
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
-
F
-
R
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
-
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
72
Fugue
93.79
47%
-105
- C5 -
1B4K
3
HEM2_PSEAE
A:
[10-335]
-
Y
P
Y
-
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
TP
V
---
E
K
--
K
S
L
D
-
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
A
L
D
P
F
T
T
H
G
Q
D
G
I
L
D
D
-
D
-
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
I
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
D
A
V
G
S
A
S
N
L
--
G
KG
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
F
R
--
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
A
E
-
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
8
PsiBlast_PDB
93.65
47%
-105
- C5 -
1W5O
4
HEM2_PSEAE
A:
[12-335]
----
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
T-
P
---
V
E
--
K
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
C
L
C
P
F
T
T
H
G
Q
C
G
I
L
-
D
-
D
D
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
D
A
V
G
S
A
S
N
L
GK
G
--
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
-
F
-
R
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
-
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
22
PsiBlast_CBE
93.36
52%
-104
- C5 -
1W1Z
2
HEM2_CHLP8
B:
[24-327]
------------------
N
L
V
-
Q
E
N
T
L
T
V
N
D
L
V
F
P
L
F
V
M
P
G
T
N
A
V
E
E
V
S
S
M
P
G
S
F
R
F
T
I
D
R
A
V
E
E
C
K
E
L
Y
D
L
G
I
Q
G
I
D
L
F
G
---
I
--
P
---
E
Q
--
K
T
E
D
-
G
S
E
A
Y
N
D
N
G
I
L
Q
Q
A
I
R
A
I
K
K
A
V
P
E
L
C
I
M
T
D
V
A
L
D
P
F
T
P
F
G
H
D
G
L
V
-
K
-
D
-
G
I
I
L
N
D
E
T
V
E
V
L
Q
K
M
A
V
S
H
A
E
A
G
A
D
F
V
S
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
D
E
T
D
H
-
S
-
D
-
V
G
I
L
S
Y
A
A
K
Y
A
S
S
F
Y
G
P
F
R
D
A
L
H
S
A
P
Q
F
--
G
--
D
K
S
T
Y
Q
M
N
P
A
N
T
E
E
A
M
K
E
V
E
L
D
I
V
E
G
A
D
I
V
M
V
K
P
G
L
A
Y
L
D
I
V
W
R
T
K
E
-
R
-
F
-
D
V
P
V
A
I
Y
H
V
S
G
E
Y
A
M
V
K
A
A
A
A
K
G
W
I
D
E
D
R
V
M
M
E
S
L
L
C
M
K
R
A
G
A
D
I
I
F
T
Y
Y
A
K
E
A
A
K
K
L
--
5
PsiBlast_PDB
93.36
51%
-100
- C5 -
1L6Y
6
HEM2_ECOLI
A:
[6-318]
------
R
P
R
R
L
R
K
S
P
A
L
R
A
M
F
-
E
E
T
T
L
S
L
N
D
L
V
L
P
I
F
V
E
E
E
I
D
D
Y
K
A
V
E
A
M
P
G
V
M
R
I
P
E
K
H
L
A
R
E
I
E
R
I
A
N
A
G
I
R
S
V
M
T
F
G
---
I
--
S
---
H
H
--
T
D
E
T
-
G
S
D
A
W
R
E
D
G
L
V
A
R
M
S
R
I
C
K
Q
T
V
P
E
M
I
V
M
S
D
T
C
F
C
E
Y
T
S
H
G
H
C
G
V
L
-
C
-
E
-
H
G
V
D
N
D
A
T
L
E
N
L
G
K
Q
A
V
V
A
A
A
A
G
A
D
F
I
A
P
S
A
A
M
D
G
Q
V
Q
A
I
R
Q
A
L
D
A
A
G
F
-
K
-
D
-
T
A
I
M
S
Y
S
T
K
F
A
S
S
F
Y
G
P
F
R
E
A
A
G
S
A
L
K
---
G
--
D
R
K
S
Y
Q
M
N
P
M
N
R
R
E
A
I
R
E
S
L
L
D
E
A
Q
G
A
D
C
L
M
V
K
P
A
G
A
Y
L
D
I
V
R
E
L
R
E
-
R
-
T
-
E
L
P
I
G
A
Y
Q
V
S
G
E
Y
A
M
I
K
F
A
A
L
A
G
A
I
D
E
E
K
V
V
L
E
S
L
G
S
I
K
R
A
G
A
D
L
I
F
S
Y
F
A
L
D
L
A
E
----
2
PsiBlast_PDB
93.18
52%
-105
- C5 -
2C1H
2
HEM2_CHLP8
A:
[24-327]
------------------
N
L
V
-
Q
E
N
T
L
T
V
N
D
L
V
F
P
L
F
V
M
P
G
T
N
A
V
E
E
V
S
S
M
P
G
S
F
R
F
T
I
D
R
A
V
E
E
C
K
E
L
Y
D
L
G
I
Q
G
I
D
L
F
G
---
I
--
P
---
E
Q
--
K
T
E
D
-
G
S
E
A
Y
N
D
N
G
I
L
Q
Q
A
I
R
A
I
K
K
A
V
P
E
L
C
I
M
T
D
V
A
L
D
P
F
T
P
F
G
H
D
G
L
V
-
K
-
D
-
G
I
I
L
N
D
E
T
V
E
V
L
Q
K
M
A
V
S
H
A
E
A
G
A
D
F
V
S
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
D
E
T
D
H
-
S
-
D
-
V
G
I
L
S
Y
A
A
K
Y
A
S
S
F
Y
G
P
F
R
D
A
L
H
S
A
P
Q
F
--
G
--
D
K
S
T
Y
Q
M
N
P
A
N
T
E
E
A
M
K
E
V
E
L
D
I
V
E
G
A
D
I
V
M
V
K
P
G
L
A
Y
L
D
I
V
W
R
T
K
E
-
R
-
F
-
D
V
P
V
A
I
Y
H
V
S
G
E
Y
A
M
V
K
A
A
A
A
K
G
W
I
D
E
D
R
V
M
M
E
S
L
L
C
M
K
R
A
G
A
D
I
I
F
T
Y
Y
A
K
E
A
A
K
K
L
--
14
PsiBlast_PDB
93.16
46%
-104
- C5 -
1GZG
5
HEM2_PSEAE
A:
[12-335]
----
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
T-
P
---
V
E
--
K
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
A
L
D
P
F
T
T
H
G
Q
N
G
I
L
-
D
-
D
D
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
D
A
V
G
S
A
S
N
L
GK
G
--
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
-
F
-
R
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
-
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
21
PsiBlast_CBE
93.00
52%
-104
- C5 -
2C1H
2
HEM2_CHLP8
B:
[24-327]
------------------
N
L
V
-
Q
E
N
T
L
T
V
N
D
L
V
F
P
L
F
V
M
P
G
T
N
A
V
E
E
V
S
S
M
P
G
S
F
R
F
T
I
D
R
A
V
E
E
C
K
E
L
Y
D
L
G
I
Q
G
I
D
L
F
G
---
I
--
P
---
E
Q
--
K
T
E
D
-
G
S
E
A
Y
N
D
N
G
I
L
Q
Q
A
I
R
A
I
K
K
A
V
P
E
L
C
I
M
T
D
V
A
L
D
P
F
T
P
F
G
H
D
G
L
V
-
K
-
D
-
G
I
I
L
N
D
E
T
V
E
V
L
Q
K
M
A
V
S
H
A
E
A
G
A
D
F
V
S
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
D
E
T
D
H
-
S
-
D
-
V
G
I
L
S
Y
A
A
K
Y
A
S
S
F
Y
G
P
F
R
D
A
L
H
S
A
P
Q
F
--
G
--
D
K
S
T
Y
Q
M
N
P
A
N
T
E
E
A
M
K
E
V
E
L
D
I
V
E
G
A
D
I
V
M
V
K
P
G
L
A
Y
L
D
I
V
W
R
T
K
E
-
R
-
F
-
D
V
P
V
A
I
Y
H
V
S
G
E
Y
A
M
V
K
A
A
A
A
K
G
W
I
D
E
D
R
V
M
M
E
S
L
L
C
M
K
R
A
G
A
D
I
I
F
T
Y
Y
A
K
E
A
A
K
K
L
--
26
PsiBlast_CBE
92.95
47%
-107
- C5 -
1W5O
4
HEM2_PSEAE
B:
[12-335]
----
Y
T
R
L
R
R
N
R
R
D
D
F
S
R
R
L
V
-
R
E
N
V
L
T
V
D
D
L
I
L
P
V
F
V
L
D
G
V
N
Q
R
E
S
I
P
S
M
P
G
V
E
R
L
S
I
D
Q
L
L
I
E
A
E
E
W
V
A
L
G
I
P
A
L
A
L
F
P
---
V
T-
P
---
V
E
--
K
K
S
L
D
A
A
E
A
Y
N
P
E
G
I
A
Q
R
A
T
R
A
L
R
E
R
F
P
E
L
G
I
I
T
D
V
C
L
C
P
F
T
T
H
G
Q
C
G
I
L
-
D
-
D
D
G
Y
V
L
N
D
V
S
I
D
V
L
V
R
Q
A
L
S
H
A
E
A
G
A
Q
V
V
A
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
E
S
A
G
H
-
T
-
N
-
V
R
V
M
A
Y
S
A
K
Y
A
S
A
Y
Y
G
P
F
R
D
A
V
G
S
---------
N
K
A
T
Y
Q
M
D
P
A
N
S
D
E
A
L
H
E
V
A
A
D
L
A
E
G
A
D
M
V
M
V
K
P
G
M
P
Y
L
D
I
V
R
R
V
K
D
-
E
-
F
-
R
A
P
T
F
V
Y
Q
V
S
G
E
Y
A
M
H
M
G
A
I
Q
N
G
W
L
-
A
E
S
V
I
L
E
S
L
T
A
F
K
R
A
G
A
D
G
I
L
T
Y
F
A
K
Q
A
A
E
Q
L
R
R
1
PsiBlast_PDB
92.28
52%
-106
- C5 -
1W1Z
2
HEM2_CHLP8
A:
[24-327]
------------------
N
L
V
-
Q
E
N
T
L
T
V
N
D
L
V
F
P
L
F
V
M
P
G
T
N
A
V
E
E
V
S
S
M
P
G
S
F
R
F
T
I
D
R
A
V
E
E
C
K
E
L
Y
D
L
G
I
Q
G
I
D
L
F
G
---
I
--
P
---
E
Q
--
K
T
E
D
-
G
S
E
A
Y
N
D
N
G
I
L
Q
Q
A
I
R
A
I
K
K
A
V
P
E
L
C
I
M
T
D
V
A
L
D
P
F
T
P
F
G
H
D
G
L
V
-
K
-
D
-
G
I
I
L
N
D
E
T
V
E
V
L
Q
K
M
A
V
S
H
A
E
A
G
A
D
F
V
S
P
S
D
M
M
D
G
R
I
G
A
I
R
E
A
L
D
E
T
D
H
-
S
-
D
-
V
G
I
L
S
Y
A
A
K
Y
A
S
S
F
Y
G
P
F
R
D
A
L
H
S
A
P
Q
F
--
G
--
D
K
S
T
Y
Q
M
N
P
A
N
T
E
E
A
M
K
E
V
E
L
D
I
V
E
G
A
D
I
V
M
V
K
P
G
L
A
Y
L
D
I
V
W
R
T
K
E
-
R
-
F
-
D
V
P
V
A
I
Y
H
V
S
G
E
Y
A
M
V
K
A
A
A
A
K
G
W
I
D
E
D
R
V
M
M
E
S
L
L
C
M
K
R
A
G
A
D
I
I
F
T
Y
Y
A
K
E
A
A
K
K
L
--
3
PsiBlast_PDB
92.04
51%
-96
- C5 -
1B4E
10
HEM2_ECOLI
A:
[6-318]
------
R
P
R
R
L
R
K
S
P
A
L
R
A
M
F
-
E
E
T
T
L
S
L
N
D
L
V
L
P
I
F
V
E
E
E
I
D
D
Y
K
A
V
E
A
M
P
G
V
M
R
I
P
E
K
H
L
A
R
E
I
E
R
I
A
N
A
G
I
R
S
V
M
T
F
G
---
I
--
S
---
H
H
--
T
D
E
T
-
G
S
D
A
W
R
E
D
G
L
V
A
R
M
S
R
I
C
K
Q
T
V
P
E
M
I
V
M
S
D
T
C
F
C
E
Y
T
S
H
G
H
C
G
V
L
-
K
-
E
-
H
G
V
D
N
D
A
T
L
E
N
L
G
K
Q
A
V
V
A
A
A
A
G
A
D
F
I
A
P
S
A
A
M
D
G
Q
V
Q
A
I
R
Q
A
L
D
A
A
G
F
-
K
-
D
-
T
A
I
M
S
Y
S
T
K
F
A
S
S
F
Y
G
P
F
R
E
A
A
G
S
A
L
K
---
G
--
D
R
K
S
Y
Q
M
N
P
M
N
R
R
E
A
I
R
E
S
L
L
D
E
A
Q
G
A
D
C
L
M
V
K
P
A
G
A
Y
L
D
I
V
R
E
L
R
E
-
R
-
T
-
E
L
P
I
G
A
Y
Q
V
S
G
E
Y
A
M
I
K
F
A
A
L
A
G
A
I
D
E
E
K
V
V
L
E
S
L
G
S
I
K
R
A
G
A
D
L
I
F
S
Y
F
A
L
D
L
A
E
----