@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1564: (2016-03-26 )
MPEMPEVENVRATLQELVPGKKIDQVIVRVPKMIVSTPPDEFVHMLVGQEIEGVRRRGKFLLFDLTNCTILSHLRMEGKFRLMDENEEVSKHTHIIFHFEDHTELRFLDVRKFGTMEVTNKYGEGETRSIKKLGPEPLTQAFTLTDFATGVKKTSRAIKTALLDQKLVAGVGNIYADEICFEAKVRPERAANSLSDKEIKRIFKATKSIMTEAVALGGSTVRTYVNSQGKLGQYQNKLKVYGKTDEPCVVCGTPIEKIKLNGRGTHFCPNCQK
Atome Classification :
(66 SA)
.........10........20.......-.30....-....40--........50........60....-..-..70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......--250........260.......270.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPEMP
E
V
E
N
V
R
A
T
L
Q
E
LVPG
K
K
I
D
Q
V
I
V
-RV
P
K
M
I
V-ST
P
P
D
E
--
F
V
H
M
L
V
G
Q
E
I
E
G
V
R
RRG
K
F
L
L
F
DL-TN-C
T
I
L
S
H
LRME
G
K
F
R
L
MDENEEVSKH
T
H
I
I
F
H
FEDHT
E
L
R
F
L
D
V
R
KFG
T
M
E
V
TNKYGEGE
T
R
S
I
K
KLGP
E
P
L
T
Q
A
F
T
L
T
D
F
A
T
G
V
K
K
T
S
R
A
I
K
T
A
L
L
D
Q
K
L
V
A
G
V
G
NI
Y
A
D
E
I
C
FEAKV
R
P
E
R
AANSL
S
D
K
E
I
K
R
I
F
K
A
T
K
S
I
M
T
E
A
V
ALG
G
S
T
V
R
T
Y
V
NSQGK
L
G
Q
Y
Q
N
K
L
KVYGKTDE
P
C
V
--
V
C-GTP
I
E
K
I
K
LNGRGTHFCPNCQK
95
Fugue
84.69
47%
-77
* C11 *
1L1Z
3
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
I
I
R
H
P
R
D
S
E
A
--
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
--
D
R
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
----------
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
3
PsiBlast_PDB
84.51
49%
-76
- C11 -
1L2B
4
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
---------
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
2
PsiBlast_PDB
84.49
49%
-77
- C11 -
1L1Z
3
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
----------
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
12
PsiBlast_PDB
84.11
48%
-70
- C11 -
2F5S
3
?
A:
[2-274]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
7
PsiBlast_PDB
83.82
48%
-71
- C11 -
1R2Z
3
?
A:
[2-274]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
24
PsiBlast_CBE
83.76
48%
-84
- C11 -
3GPP
3
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
17
PsiBlast_PDB
83.75
48%
-70
- C11 -
3JR5
4
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
C
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
18
PsiBlast_PDB
83.70
48%
-72
- C11 -
3GPY
3
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
1
PsiBlast_PDB
83.37
49%
-79
- C11 -
1L1T
3
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
--------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
19
PsiBlast_PDB
83.20
48%
-71
- C11 -
3GQ4
4
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
26
PsiBlast_CBE
83.08
48%
-83
- C11 -
3SAT
4
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
A
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
13
PsiBlast_PDB
83.05
48%
-85
- C11 -
3SAR
7
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
--------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
6
PsiBlast_PDB
82.93
48%
-71
- C11 -
1R2Y
3
?
A:
[2-274]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
25
PsiBlast_CBE
82.86
48%
-87
- C11 -
3SAW
3
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
A
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
4
PsiBlast_PDB
82.85
49%
-77
- C11 -
1L2C
3
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
--------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
11
PsiBlast_PDB
82.60
48%
-67
- C11 -
2F5Q
3
?
A:
[2-274]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
V
R
T
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
10
PsiBlast_PDB
82.47
48%
-80
- C11 -
2F5P
3
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
-------------------
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
15
PsiBlast_PDB
82.43
48%
-87
- C11 -
3SAV
3
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
23
PsiBlast_CBE
82.30
48%
-86
- C11 -
3GQ5
5
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
21
PsiBlast_CBE
82.30
48%
-87
- C11 -
3SBJ
3
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
8
PsiBlast_PDB
82.26
48%
-84
- C11 -
2F5N
5
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
14
PsiBlast_PDB
82.23
48%
-86
- C11 -
3SAU
3
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
----------------------
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
16
PsiBlast_PDB
82.13
48%
-76
- C11 -
3JR4
3
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
C
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
T
----------
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
5
PsiBlast_PDB
82.10
49%
-78
- C11 -
1L2D
3
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
G
G
S
--------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
9
PsiBlast_PDB
81.94
48%
-83
- C11 -
2F5O
4
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
27
PsiBlast_CBE
81.87
48%
-84
- C11 -
3SAS
3
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
A
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
--------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
20
PsiBlast_PDB
81.86
48%
-85
- C11 -
3GP1
3
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
30
PsiBlast_CBE
81.68
47%
-86
- C11 -
3U6Q
3
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
---------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
22
PsiBlast_CBE
81.67
48%
-84
- C11 -
4G4N
3
?
A:
[1-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
E
D
V
R
I
-
F
W
P
N
-
I
I
-
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
R
-
D
A
L
I
S
H
L
R
A
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
V
M
K
--------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
K
--
R
C
-
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
36
PsiBlast_CBE
81.65
47%
-85