@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1587: (2016-03-26 )
MTMYAKNNTSGKDMLSLLEWNKEELTDIIKLAVAMKTNPAHYSHILSGKILGMIFDKPSTRTRVSFEAGILQLGGQAIVMSSKELQIGRGEPIKDTAHVMSEYIDAIMIRTFSHEKVEELAYHAEIPIINGLTDLHHPCQALADLMTIYEWKDQLEGIKLAYIGDGNNVCHSLLLAGAMVGIDIRLAMPKGYEVDETILAKAENLAKQSGGKIFVTEDSKLAVTDADFIYTDVWTSMGQEDENAKRLADFGEKYQVNAELVSGAKPDYHFLHCLPAHREEEVTTEIIDGIHSVIYQQAGNRLHAQKALLAAILEAK
Atome Classification :
(39 SA)
.........10........20........30.----....---..--.40--.........50.----.......60........70........80........90........100.......110.......120.......130.......140.......150--..--....-----..160....-.-..170.......180.......190.......200.......210.......220.......230.......-240.-......250.......260.-.......270....-...280----------------.........290.......300.......310....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
M
Y
AKNNTS
G
K
D
M
L
S
L
L
EW
N
K
E
E
L
T
D
I
I
K
L
A
----
V
AMK---TN--
P
A
---
H
Y
S
H
I
LSG
K
I
L
G
----
M
I
FDKPST
R
T
R
V
S
FE
A
G
I
L
QLG
G
Q
A
I
V
M
SSK
E
L
QIGRGEPI
K
D
T
A
H
V
M
S
E
Y
I
D
A
I
M
I
R
TF
S
H
E
K
V
E
E
L
A
YHAEIPIIN
G
L
T
D
L
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
W
---
K
D
--QLE
G
-----
I
K
L
A
Y
IGD
G
-
N
-
N
V
C
H
S
L
L
L
A
G
A
M
V
G
I
D
I
R
LAMPKGYE
V
D
E
T
I
L
A
K
A
E
N
L
A
K
QSG
G
K
I
F
V
TED
S
K
L
A
V
TDA
D
F
I
Y
T
D
V
W
T
SMGQ-ED
E
N
-
A
K
R
L
A
DFGE
K
Y
Q
V
N
A
E
LV-S-GAKPD
Y
H
F
L
H
CLPA-H
R
E
E
------------------
E
V
T
T
E
I
I
D
G
I
H
S
V
I
Y
Q
QAGN
R
L
H
A
Q
K
A
L
L
A
A
I
LEAK
21
PsiBlast_CBE
96.18
60%
-119
- C4 -
4NF2
4
OTC_BACAN
C:
[36-334]
-----------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
---
K
N
--
K
Q
-----
E
P
L
L
Q
G
K
I
L
G
----
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
---
T
N
--
T
F
K
G
-----
I
K
L
A
Y
V
G
D
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
G
E
E
-
E
K
Y
--
T
L
F
Q
P
Y
Q
I
N
K
E
L
V
-
K
-
H
A
K
Q
T
Y
H
F
L
H
C
L
P
A
-
H
R
E
E
------------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
--
2
PsiBlast_PDB
96.17
60%
-120
- C4 -
4NF2
5
OTC_BACAN
A:
[36-334]
-----------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
---
K
N
--
K
Q
-----
E
P
L
L
Q
G
K
I
L
G
----
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
---
T
N
--
T
F
K
G
-----
I
K
L
A
Y
V
G
D
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
G
E
E
-
E
K
Y
--
T
L
F
Q
P
Y
Q
I
N
K
E
L
V
-
K
-
H
A
K
Q
T
Y
H
F
L
H
C
L
P
A
-
H
R
E
E
------------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
--
22
PsiBlast_CBE
96.08
60%
-120
- C4 -
4NF2
5
OTC_BACAN
B:
[36-334]
-----------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
---
K
N
--
K
Q
-----
E
P
L
L
Q
G
K
I
L
G
----
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
---
T
N
--
T
F
K
G
-----
I
K
L
A
Y
V
G
D
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
G
E
E
-
E
K
Y
--
T
L
F
Q
P
Y
Q
I
N
K
E
L
V
-
K
-
H
A
K
Q
T
Y
H
F
L
H
C
L
P
A
-
H
R
E
E
------------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
--
1
PsiBlast_PDB
93.24
60%
-123
- C4 -
4EP1
-
OTC_BACAN
A:
[12-310]
-----------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
---
K
N
--
K
Q
-----
E
P
L
L
Q
G
K
I
L
G
----
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
------
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
---
T
N
--
T
F
K
G
-----
I
K
L
A
Y
V
G
D
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
-------
G
E
E
-
E
K
Y
--
T
L
F
Q
P
Y
Q
I
N
K
E
L
V
-
K
-
H
A
K
Q
T
Y
H
F
L
H
C
L
P
A
-
H
R
E
E
------------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
--
3
PsiBlast_PDB
93.02
52%
-117
- C4 -
1PVV
2
OTC_PYRFU
A:
[6-310]
---------
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
I
W
Q
K
---
I
G
--
K
P
---
H
--
R
L
L
E
G
K
T
L
A
----
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
---
K
G
--
T
I
K
G
-----
V
K
V
V
Y
V
G
D
G
-
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
V
I
K
W
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
A
E
A
-
E
E
R
R
K
I
F
-
R
P
F
Q
V
N
K
D
L
V
-
K
-
H
A
K
P
D
Y
M
F
M
H
C
L
P
A
-
H
R
G
E
------------------
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
---
4
PsiBlast_PDB
91.06
52%
-114
- C4 -
1A1S
-
OTC_PYRFU
A:
[5-309]
---------
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
I
W
Q
K
---
I
G
--
K
P
---
H
--
R
L
L
E
G
K
T
L
A
----
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
---
K
G
--
T
I
K
G
-----
V
K
V
V
Y
V
G
D
G
-
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
V
I
K
W
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
A
E
A
-
E
E
R
R
K
I
F
-
R
P
F
Q
V
N
K
D
L
V
-
K
-
H
A
K
P
D
Y
M
F
M
H
C
L
P
A
-
H
R
G
E
------------------
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
---
89
HHSearch
90.69
52%
-106
- C4 -
1PVV
2
OTC_PYRFU
A:
[2-313]
-----
V
V
S
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
----
K
M
F
K
---
I
W
--
Q
K
I
G-
K
P
H
R
L
L
E
G
K
T
L
A
----
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
---
K
G
--
T
I
K
G
-----
V
K
V
V
Y
V
G
D
G
-
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
V
I
K
W
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
A
E
A
-
E
E
R
R
K
I
F
-
R
P
F
Q
V
N
K
D
L
V
-
K
-
H
A
K
P
D
Y
M
F
M
H
C
L
P
A
-
H
R
G
E
------------------
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
G
I
91
HHSearch
89.88
45%
-112
- C4 -
2I6U
5
OTC_MYCTU
A:
[2-306]
----------
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
--
P
V
---
S
R
R
P
L
Q
G
P
R
G
V
A
----
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
---
K
G
--
A
L
R
G
-----
L
R
L
S
Y
F
G
D
G
-
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
D
G
-
L
D
R
V
K
P
F
-
R
P
F
Q
L
N
S
R
L
L
-
A
-
L
A
D
S
D
A
I
V
L
H
C
L
P
A
-
H
R
G
D
------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
-
18
PsiBlast_PDB
87.82
38%
-116
- C4 -
4A8T
3
PTC_ENTFA
A:
[25-331]
-----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
E
A
-
I
K
--
N
G
---
Y
Y
P
Q
L
L
K
N
K
S
L
G
----
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
-
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
LPE
G
K
--
K
L
E
D
-----
C
K
V
V
F
V
G
D
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
-
D
-
R
A
G
A
N
C
K
F
M
H
C
L
P
A
-
T
R
G
E
------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
---
25
PsiBlast_CBE
87.51
46%
-119
- C4 -
2P2G
3
OTC_MYCTU
D:
[15-305]
-----------------------
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
--
P
V
---
S
R
R
P
L
Q
G
P
R
G
V
A
----
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
---
K
G
--
A
L
R
G
-----
L
R
L
S
Y
F
G
D
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
--------------
V
K
P
F
-
R
P
F
Q
L
N
S
R
L
L
-
A
-
L
A
D
S
D
A
I
V
L
H
C
L
P
A
-
H
R
G
D
------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
--
90
HHSearch
87.47
48%
-114
- C4 -
3GD5
-
OTC_GLOVI
A:
[10-313]
-------
T
R
F
R
P
D
L
L
S
L
D
D
L
D
E
A
Q
L
H
A
L
L
T
L
A
----
H
Q
L
K
---
R
G
--
E
-----
R
V
A
N
L
H
G
K
V
L
G
----
L
V
F
L
K
A
S
T
R
T
R
V
S
F
T
V
A
M
Y
Q
L
G
G
Q
V
I
D
L
----------
E
P
V
R
D
T
A
R
V
L
G
R
Y
V
D
G
L
A
I
R
T
F
A
Q
T
E
L
E
E
Y
A
H
Y
A
G
I
P
V
I
N
A
L
T
D
H
E
H
P
C
Q
V
V
A
D
L
L
T
I
R
E
N
---
F
G
--
R
L
A
G
-----
L
K
L
A
Y
V
G
D
G
-
N
-
N
V
A
H
S
L
L
L
G
C
A
K
V
G
M
S
I
A
V
A
T
P
E
G
F
T
P
D
P
A
V
S
A
R
A
S
E
I
A
G
R
T
G
A
E
V
Q
I
L
R
D
P
F
E
A
A
R
G
A
H
I
L
Y
T
D
V
W
T
-----------
H
R
L
Q
L
F
-
E
Q
Y
Q
I
N
A
A
L
L
-
N
-
C
A
A
A
E
A
I
V
L
H
C
L
P
A
-
H
R
G
E
------------------
E
I
T
D
E
V
M
E
G
P
R
S
R
I
W
D
E
A
E
N
R
L
H
A
Q
K
A
V
L
A
A
L
M
G
--
92
HHSearch
87.43
42%
-117
- C4 -
3TPF
1
OTC_CAMJE
A:
[2-304]
----------
M
K
H
F
L
T
L
R
D
F
S
K
E
E
I
L
S
L
V
N
H
A
----
S
E
L
K
---
K
E
--
P
------
K
K
L
L
Q
D
K
T
L
A
----
M
I
F
E
K
N
S
T
R
T
R
M
A
F
E
L
A
I
T
E
L
G
G
K
A
L
F
L
S
S
N
D
L
Q
L
S
R
G
E
P
V
K
D
T
A
R
V
I
G
A
M
V
D
F
V
M
M
R
V
N
K
H
E
T
L
L
E
F
A
R
Y
S
K
A
P
V
I
N
A
L
S
E
L
Y
H
P
T
Q
V
L
G
D
L
F
T
I
K
E
W
---
N
K
--
M
Q
N
G
I----
A
K
V
A
F
I
G
D
S
-
N
-
N
M
C
N
S
W
L
I
T
A
A
I
L
G
F
E
I
S
I
A
M
P
K
N
Y
K
I
S
P
E
I
W
E
F
A
M
K
Q
A
L
I
S
G
A
K
I
S
L
G
Y
D
K
F
E
A
L
K
D
K
D
V
V
I
T
D
T
W
V
S
M
G
E
-
E
N
E
K
-
E
R
K
I
K
E
F
-
E
G
F
M
I
D
E
K
A
M
-
S
-
V
A
N
K
D
A
I
L
L
H
C
L
P
A
-
Y
R
G
Y
------------------
E
V
S
E
E
I
F
E
K
H
A
D
V
I
F
E
E
A
R
N
R
L
Y
V
V
K
A
L
L
C
F
L
D
N
Q
R
67
PsiBlast_CBE
87.43
38%
-116
- C4 -
4AM8
5
PTC_ENTFA
B:
[3-309]
-----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
E
A
-
I
K
--
N
G
---
Y
Y
P
Q
L
L
K
N
K
S
L
G
----
M
I
F
Q
Q
S
S
T
G
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
-
Q
I
Q
L
G
-
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
LPE
G
K
--
K
L
E
D
-----
C
K
V
V
F
V
G
D
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
-
D
-
R
A
G
A
N
C
K
F
M
H
C
L
P
A
-
T
R
G
E
------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
---
26
PsiBlast_CBE
87.38
46%
-117
- C4 -
2P2G
5
OTC_MYCTU
C:
[15-305]
-----------------------
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
--
P
V
---
S
R
R
P
L
Q
G
P
R
G
V
A
----
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
---
K
G
--
A
L
R
G
-----
L
R
L
S
Y
F
G
D
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
-----------
R
V
K
P
F
-
R
P
F
Q
L
N
S
R
L
L
-
A
-
L
A
D
S
D
A
I
V
L
H
C
L
P
A
-
H
R
G
D
------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
--
28
PsiBlast_CBE
87.35
46%
-114
- C4 -
2I6U
5
OTC_MYCTU
C:
[15-305]
-----------------------
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
--
P
V
---
S
R
R
P
L
Q
G
P
R
G
V
A
----
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
---
K
G
--
A
L
R
G
-----
L
R
L
S
Y
F
G
D
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
D
G
-
L
D
R
V
K
P
F
-
R
P
F
Q
L
N
S
R
L
L
-
A
-
L
A
D
S
D
A
I
V
L
H
C
L
P
A
-
H
R
G
D
------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
--
66
PsiBlast_CBE
87.26
38%
-118
- C4 -
4AM8
5
PTC_ENTFA
C:
[3-309]
-----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
E
A
-
I
K
--
N
G
---
Y
Y
P
Q
L
L
K
N
K
S
L
G
----
M
I
F
Q
Q
S
S
T
G
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
----
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
LPE
G
K
--
K
L
E
D
-----
C
K
V
V
F
V
G
D
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
-
D
-
R
A
G
A
N
C
K
F
M
H
C
L
P
A
-
T
R
G
E
------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
---
7
PsiBlast_PDB
87.11
46%
-114
- C4 -
2I6U
5
OTC_MYCTU
A:
[15-305]
-----------------------
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
--
P
V
---
S
R
R
P
L
Q
G
P
R
G
V
A
----
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
---
K
G
--
A
L
R
G
-----
L
R
L
S
Y
F
G
D
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
D
G
-
L
D
R
V
K
P
F
-
R
P
F
Q
L
N
S
R
L
L
-
A
-
L
A
D
S
D
A
I
V
L
H
C
L
P
A
-
H
R
G
D
------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
--
35
PsiBlast_CBE
87.00
38%
-116
- C4 -
4A8P
4
PTC_ENTFA
B:
[3-309]
-----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
E
A
-
I
K
--
N
G
---
Y
Y
P
Q
L
L
K
N
K
S
L
G
----
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
LP-
G
K
--
K
L
E
D
-----
C
K
V
V
F
V
G
D
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
-
D
-
R
A
G
A
N
C
K
F
M
H
C
L
P
A
-
T
R
G
E
------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
---
20
PsiBlast_PDB
86.95
38%
-113
- C4 -
4A8P
3
PTC_ENTFA
A:
[3-309]
-----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
E
A
-
I
K
--
N
G
---
Y
Y
P
Q
L
L
K
N
K
S
L
G
----
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
LPE
G
K
--
K
L
E
D
-----
C
K
V
V
F
V
G
D
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
-
D
-
R
A
G
A
N
C
K
F
M
H
C
L
P
A
-
T
R
G
E
------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
---
29
PsiBlast_CBE
86.89
46%
-111
- C4 -
2I6U
5
OTC_MYCTU
B:
[15-305]
-----------------------
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
--
P
V
---
S
R
R
P
L
Q
G
P
R
G
V
A
----
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
---
K
G
--
A
L
R
G
-----
L
R
L
S
Y
F
G
D
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
D
G
-
L
D
R
V
K
P
F
-
R
P
F
Q
L
N
S
R
L
L
-
A
-
L
A
D
S
D
A
I
V
L
H
C
L
P
A
-
H
R
G
D
------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
--
30
PsiBlast_CBE
86.86
39%
-113
- C4 -
1FVO
1
OTC_HUMAN
B:
[6-309]
----------
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
FRI
K
Q
--
K
G
---
E
Y
L
P
L
L
Q
G
K
S
L
G
----
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
--
S
L
K
G
-----
L
T
L
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
-
Q
G
Y
Q
V
T
M
K
T
A
-
K
-
V
A
A
S
D
W
T
F
L
H
C
L
P
--
R
K
P
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
---
12
PsiBlast_PDB
86.56
39%
-109
- C4 -
1OTH
1
OTC_HUMAN
A:
[6-309]
----------
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
K
Q
--
K
G
---
E
Y
L
P
L
L
Q
G
K
S
L
G
----
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
--
S
L
K
G
-----
L
T
L
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
-
Q
G
Y
Q
V
T
M
K
T
A
-
K
-
V
A
A
S
D
W
T
F
L
H
C
L
P
--
R
K
P
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
---
13
PsiBlast_PDB
86.51
39%
-110
- C4 -
1C9Y
2
OTC_HUMAN
A:
[6-309]
----------
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
K
Q
--
K
G
---
E
Y
L
P
L
L
Q
G
K
S
L
G
----
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
--
S
L
K
G
-----
L
T
L
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
-
Q
G
Y
Q
V
T
M
K
T
A
-
K
-
V
A
A
S
D
W
T
F
L
H
C
L
P
--
R
K
P
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
---
14
PsiBlast_PDB
86.38
39%
-111
- C4 -
1EP9
1
OTC_HUMAN
A:
[6-309]
----------
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
K
Q
--
K
G
---
E
Y
L
P
L
L
Q
G
K
S
L
G
----
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
--
S
L
K
G
-----
L
T
L
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
-
Q
G
Y
Q
V
T
M
K
T
A
-
K
-
V
A
A
S
D
W
T
F
L
H
C
L
P
--
R
K
P
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
---
36
PsiBlast_CBE
86.14
38%
-111
- C4 -
4A8H
6
PTC_ENTFA
B:
[3-309]
-----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
EA-
I
K
--
N
G
---
Y
Y
P
Q
L
L
K
N
K
S
L
G
----
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
LPE
G
K
--
K
L
E
D
-----
C
K
V
V
F
V
G
D
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
-
D
-
R
A
G
A
N
C
K
F
M
H
C
L
P
A
-
T
R
G
E
------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
---
15
PsiBlast_PDB
86.00
39%
-109
- C4 -
1FVO
1
OTC_HUMAN
A:
[6-309]
----------
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
K
Q
--
K
G
---
E
Y
L
P
L
L
Q
G
K
S
L
G
----
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
--
S
L
K
G
-----
L
T
L
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
-
Q
G
Y
Q
V
T
M
K
T
A
-
K
-
V
A
A
S
D
W
T
F
L
H
C
L
P
--
R
K
P
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
---
94
HHSearch
85.75
40%
-105
- C4 -
1OTH
1
OTC_HUMAN
A:
[1-311]
-----
K
V
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
---
F
R
--
I
K
QKG
E
Y
L
P
L
L
Q
G
K
S
L
G
----
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
--
S
L
K
G
-----
L
T
L
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
E
K
-
K
K
R
L
Q
A
F
-
Q
G
Y
Q
V
T
M
K
T
A
-
K
-
V
A
A
S
D
W
T
F
L
H
C
L
P
R
-
K
P
-
E
------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-
19
PsiBlast_PDB
85.38
38%
-111
- C4 -
4A8H
6
PTC_ENTFA
A:
[3-309]
-----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
E
A
-
I
K
--
N
G
---
Y
Y
P
Q
L
L
K
N
K
S
L
G
----
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
LPE
G
K
--
K
L
E
D
-----
C
K
V
V
F
V
G
D
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
-
D
-
R
A
G
A
N
C
K
F
M
H
C
L
P
A
-
T
R
G
E
------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
---
56
PsiBlast_CBE
84.10
38%
-110
- C4 -
4JHX
3
OTC_VIBVU
A:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
----
A
---
K
Y
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
Q
GK
A
L
A
D
-----
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
-
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
58
PsiBlast_CBE
83.73
38%
-110
- C4 -
4JFR
3
OTC_VIBVU
B:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
----
A
---
K
Y
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
Q
GK
A
L
A
D
-----
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
-
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
83
PsiBlast_CBE
82.97
38%
-112
- C4 -
1DUV
3
OTC1_ECOLI
G:
[6-331]
-----------
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
----
A
K
L
K
---
A
D
KK
S
G
---
K
E
E
A
K
L
T
G
K
N
I
A
----
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
--------
H
L
P
G
KAFNE
M
T
L
V
Y
A
G
D
A
R
N
-
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
K
E
K
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
-
Q
L
T
G
N
P
E
V
K
F
L
H
C
L
P
A
-
F
H
D
D
QTTLGKKMAEEFGLHGGM
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
51
PsiBlast_CBE
82.90
38%
-108
- C4 -
4JQO
6
OTC_VIBVU
C:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
----
A
---
K
Y
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
Q
GK
A
L
A
D
-----
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
-
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
81
PsiBlast_CBE
82.89
38%
-110
- C4 -
1DUV
2
OTC1_ECOLI
I:
[6-331]
-----------
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
----
A
K
L
K
---
A
D
KK
S
G
---
K
E
E
A
K
L
T
G
K
N
I
A
----
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
--------
H
L
P
G
KAFNE
M
T
L
V
Y
A
G
D
A
R
N
-
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
K
E
K
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
-
Q
L
T
G
N
P
E
V
K
F
L
H
C
L
P
A
-
F
H
D
D
QTTLGKKMAEEFGLHGGM
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
59
PsiBlast_CBE
82.77
38%
-109
- C4 -
4JFR
2
OTC_VIBVU
A:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
----
A
---
K
Y
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
Q
GK
A
L
A
D
-----
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
-
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
53
PsiBlast_CBE
82.40
38%
-109
- C4 -
4JQO
8
OTC_VIBVU
A:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
----
A
---
K
Y
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
Q
GK
A
L
A
D
-----
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
-
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
62
PsiBlast_CBE
82.26
38%
-109
- C4 -
4H31
14
OTC_VIBVU
A:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
----
A
---
K
Y
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
Q
GK
A
L
A
D
-----
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
-
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
61
PsiBlast_CBE
82.20
38%
-107
- C4 -
4H31
12
OTC_VIBVU
B:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
----
A
---
K
Y
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
Q
GK
A
L
A
D
-----
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
-
W
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
GMKGL--
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
82
PsiBlast_CBE
82.03
38%
-110
- C4 -
1DUV
2
OTC1_ECOLI
H:
[6-331]
-----------
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
----
A
K
L
K
---
A
D
KK
S
G
---
K
E
E
A
K
L
T
G
K
N
I
A
----
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
--------
H
L
P
G
KAFNE
M
T
L
V
Y
A
G
D
A
R
N
-
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
K
E
K
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
-
Q
L
T
G
N
P
E
V
K
F
L
H
C
L
P
A
-
F
H
D
D
QTTLGKKMAEEFGLHGGM
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
---
52
PsiBlast_CBE
81.74
38%
-108
- C4 -
4JQO
6
OTC_VIBVU
B:
[28-356]
-------
N
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
----
A
---
K
Y
A
G
T
E
Q
K
K
L
L
G
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
Q
GK
A
L
A
D
-----
I
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GMKGL--
E
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H
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---