@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1588: (2016-03-26 )
MKHVFPTYKRFPIDLVNGTGTVVTDKNGKTYLDFTSGIAVCNLGHCPTNVAEAVQQQLGNIWHTSNLYECALQDSVAELIADGKERLVFFCNSGTESNEAALKLARKYTGKEKIITFEKSFHGRTFGSMSATGQAKIHQGFGELVPGFTYVPYNDIEAFRAEIDENTAAVMLEVIQAEGGVIPANAAFLLEVQLLCKKMGALLIIDEVQTGLGRTGTLYGFEQIGLDPDIFTLAKGLGNGLPIGAMVGKSDLISAFGPGSHGSTFGGNKLALAAAKEILLTMKQTGFLEEVNAKADYFRNLLEANLEVLDNVSDIRGGGFLIGIELENAAEPVITELRDKGLLILTAGTNVLRILPPLTVSYAEIDQAIYLLKSVLENQLIGSEEG
Atome Classification :
(49 SA)
.........10....--....20........30........40........50....---....60----.....-----...--.70..----......80.----.-.---.....90........100.....--.--------.-----110----..------.......120.......130....---.-----..140........-----150.--------------......-160---.-.-------------.....170.-......180.......190.......200.......210.......220.......230.......240-........250..-....-.260--.........270--.........280.......290.......300.....-..310.......320....----.----.--.----------330-.--.....-.-------------------------.340....----...350........360..-.....370-.......380....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKHVFPTYKRF
P
I
D
L
--VNGT
G
T
V
V
TDKNG
K
T
Y
L
D
FTS
G
I
A
V
CNLGHCP
T
N
V
A
E
A
V
Q
---
Q
Q
L
GN-----IWHTS-----
N
L
Y
--
E
C
A
L
Q
----
D
S
V
A
E
L
I
AD----G-K---
E
R
L
V
F
F
CNSGTE
S
N
E
A
A
L
K
L
A
R
K
--Y--------T-----G------KE------
K
I
I
T
F
EKSFHGRTFGSMSATG
Q
A
K
---
I
-----
H
Q
G
F
-
G
E
LVPG
F
T
-----YVPY--------------
N
D
I
E
A
F
-
R
A
E---I-D-------------E
N
T
A
A
V
M
L
E
-
V
I
QAEG
G
V
IPA
N
A
A
F
L
L
E
V
Q
L
L
C
K
KMG
A
L
L
I
I
D
E
V
Q
T
GLGRTGTLY
G
F
E
QIGLD
P
D
I
F
T
L
A
K
GLGNG-L-PIGAMVGK
S
D
L
I
S
-AFGP-GS----HGSTFGGN
K
L
----
A
L
A
A
A
K
E
I
L
L
T
M
K
QTG
F
L
E
E
VN
A
K
A
D
Y
F
R
N
L
L
E
A
N
L
E
-
V
L
D
N
V
S
DIRG
G
G
F
L
I
G
I
E
L----E----N--A----------A
E
--
P
--
V
I
T
E
L-R-------------------------DK
G
L
L
I
L
T----AGT
N
-
V
L
R
ILPPLT
V
S
Y
A
E
-
I
D
Q
A
I
Y
L
L
-
K
S
V
L
E
N
QLIGSEEG
2
PsiBlast_PDB
96.32
45%
-104
- C1 -
2E54
5
ARGD_THEMA
A:
[2-383]
--
Y
L
M
N
T
Y
S
R
F
P
A
T
F
--
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
S
H
P
R
L
V
E
A
I
K
---
D
Q
A
E
K
-----
L
I
H
C
S
-----
N
L
F
--
W
N
R
P
Q
----
M
E
L
A
E
L
L
S
K
N
T
F
G
G
-
K
------
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
--
Y
--------
G
-----
K
------
K
K
SEKKY-
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
---
Y
-----
Q
K
P
F
-
E
P
L
V
P
G
F
E
-----
Y
F
E
F
--------------
N
N
V
E
D
L
-
R
R
K
---
M
-
S
-------------
E
D
V
C
A
V
F
L
E
-
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
-
P
I
G
A
V
I
-
V
N
E
R
A
N
-
V
L
E
P
-
G
D
----
H
G
T
T
F
G
G
N
P
L
----
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
-
E
Y
D
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
RE--
E
----
V
--
S
----------
N
R
--
E
--
V
A
T
K
C
-
F
-------------------------
E
N
K
L
L
V
V
P
----
A
G
N
N
-
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
-
I
D
L
A
V
E
T
L
-
K
K
V
L
Q
---------
3
PsiBlast_PDB
95.88
45%
-109
- C1 -
2ORD
14
ARGD_THEMA
A:
[18-395]
------
T
Y
S
R
F
P
A
T
F
--
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
S
H
P
R
L
V
E
A
I
K
---
D
Q
A
E
K
-----
L
I
H
C
S
-----
N
L
F
--
W
N
R
P
Q
----
M
E
L
A
E
L
L
S
K
N
T
FG
G
-
K
------
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
--
Y
--------
G
-----
K
------
K
K
SEKKY-
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
---
Y
-----
Q
K
P
F
-
E
P
L
V
P
G
F
E
-----
Y
F
E
F
--------------
N
N
V
E
D
L
-
R
R
K
---
M
-
S
-------------
E
D
V
C
A
V
F
L
E
-
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
-
P
I
G
A
V
I
-
V
N
E
R
A
N
-
V
L
E
P
-
G
D
----
H
G
T
T
F
G
G
N
P
L
----
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
-
E
Y
D
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
R
E--
E
----
V
--
S
----------
N
R
--
E
--
V
A
T
K
C
-
F
-------------------------
E
N
K
L
L
V
V
P
----
A
G
N
N
-
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
-
I
D
L
A
V
E
T
L
-
K
K
V
L
Q
---------
21
PsiBlast_CBE
95.34
45%
-109
- C1 -
2EH6
2
ARGD_AQUAE
B:
[2-375]
--
Y
L
M
N
N
Y
A
R
L
P
V
K
F
--
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
A
Y
P
K
L
T
E
A
L
K
---
E
Q
V
E
K
-----
L
L
H
V
S
-----
N
L
Y
--
E
N
P
W
Q
----
E
E
L
A
H
K
L
V
K
HF--
W
-
T
---
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
--
Y
WRDKG---
K
-----
N
------
K
W
------
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
---
F
-----
H
K
G
F
-
E
P
L
V
P
G
F
S
-----
Y
A
K
L
--------------
N
D
I
D
S
V
-
Y
K
L
---
L
-
D
-------------
E
E
T
A
G
I
I
I
E
-
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
-
P
I
G
A
I
L
A
R
E
E
V
A
Q
-
S
F
T
P
-
G
S
----
H
G
S
T
F
G
G
N
P
L
----
A
C
R
A
G
T
V
V
V
D
E
V
E
K
--
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
L
------
G
K
G
K
V
K
G
R
G
L
M
L
G
L
E
L
----
E
----
R
--
E
----------
C
K
--
D
--
Y
V
L
K
A
-
L
-------------------------
E
K
G
L
L
I
N
C
----
T
A
G
K
-
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
-
I
D
R
A
I
S
V
L
-
R
E
I
L
----------
1
PsiBlast_PDB
94.90
45%
-110
- C1 -
2EH6
2
ARGD_AQUAE
A:
[2-375]
--
Y
L
M
N
N
Y
A
R
L
P
V
K
F
--
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
A
Y
P
K
L
T
E
A
L
K
---
E
Q
V
E
K
-----
L
L
H
V
S
-----
N
L
Y
--
E
N
P
W
Q
----
E
E
L
A
H
K
L
V
K
H
F--
W
-
T
---
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
--
Y
W
R
D
K
G---
K
-----
N
------
K
W
------
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
---
F
-----
H
K
G
F
-
E
P
L
V
P
G
F
S
-----
Y
A
K
L
--------------
N
D
I
D
S
V
-
Y
K
L
---
L
-
D
-------------
E
E
T
A
G
I
I
I
E
-
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
-
P
I
G
A
I
L
A
R
E
E
V
A
Q
-
S
F
T
P
-
G
S
----
H
G
S
T
F
G
G
N
P
L
----
A
C
R
A
G
T
V
V
V
D
E
V
E
K
--
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
L
------
G
K
G
K
V
K
G
R
G
L
M
L
G
L
E
L
----
E
----
R
--
E
----------
C
K
--
D
--
Y
V
L
K
A
-
L
-------------------------
E
K
G
L
L
I
N
C
----
T
A
G
K
-
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
-
I
D
R
A
I
S
V
L
-
R
E
I
L
----------
106
HHSearch
93.30
46%
-105
- C1 -
2ORD
14
ARGD_THEMA
A:
[17-396]
-----
N
T
Y
S
R
F
P
A
T
F
--
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
S
H
P
R
L
V
E
A
I
K
---
D
Q
A
E
K
-----
L
I
H
C
S
-----
N
L
F
--
W
N
R
P
Q
----
M
E
L
A
E
L
L
S
K
----
N
-
T
F--
G
G
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
--
Y
--------
G
-----
K
K
K
SEK-
K
Y
------
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
---
Y
-----
Q
K
P
F
-
E
P
L
V
P
G
F
E
-----
Y
F
E
F
--------------
N
N
V
E
D
L
-
R
R
K
---
M
-
S
-------------
E
D
V
C
A
V
F
L
E
-
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
-
P
I
G
A
V
I
V
N
E
R
A
-
N
-
V
L
E
P
-
G
D
----
H
G
T
T
F
G
G
N
P
L
----
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
-
E
Y
D
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
----
R
----
E
EV
S
----------
N
R
--
E
--
V
A
T
K
C
-
F
-------------------------
E
N
K
L
L
V
V
P
----
A
G
N
N
-
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
-
I
D
L
A
V
E
T
L
-
K
K
V
L
Q
G
--------
121
HHSearch
90.64
45%
-104
- C1 -
2EH6
2
ARGD_AQUAE
A:
[5-374]
-----
N
N
Y
A
R
L
P
V
K
F
--
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
A
Y
P
K
L
T
E
A
L
K
---
E
Q
V
E
K
-----
L
L
H
V
S
-----
N
L
Y
--
E
N
P
W
Q
----
E
E
L
A
H
K
L
V
K
----
H
F
W
T
--
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
--
Y
--------
W
R
D
K
GK
N
------
K
W
------
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
---
F
-----
H
K
G
F
-
E
P
L
V
P
G
F
S
-----
Y
A
K
L
--------------
N
D
I
D
S
V
-
Y
K
L
---
L
-
D
-------------
E
E
T
A
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
-
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
-
P
I
G
A
I
L
A
R
E
E
V
A
Q
-
S
F
T
P
-
G
S
----
H
G
S
T
F
G
G
N
P
L
----
A
C
R
A
G
T
V
V
V
D
E
V
E
--
K
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
L
G
---
K
G
K
---
V
K
G
R
G
L
M
L
G
L
E
L
----
E
----
R
--
E
----------
C
K
--
D
--
Y
V
L
K
A
-
L
-------------------------
E
K
G
L
L
I
N
C
----
T
A
G
K
-
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
-
I
D
R
A
I
S
V
L
-
R
E
I
-----------
105
HHSearch
87.46
39%
-102
- C1 -
3NX3
3
ARGD_CAMJE
A:
[10-394]
--
H
I
I
P
T
Y
K
R
F
D
I
V
L
--
E
K
G
Q
G
V
Y
L
F
D
D
K
A
K
K
Y
L
D
F
S
S
G
I
G
V
C
A
L
G
Y
N
H
A
K
F
N
A
K
I
K
---
A
Q
V
D
K
-----
L
L
H
T
S
-----
N
L
Y
--
Y
N
E
N
I
----
A
A
A
A
K
N
L
A
K
----
A
-
S
A--
L
E
R
V
F
F
T
N
S
G
T
E
S
I
E
G
A
M
K
T
A
R
K
--
Y
--------
A
F
N
K
GV
K
------
G
G
------
Q
F
I
A
F
K
H
S
F
H
G
R
T
L
G
A
L
S
L
T
A
N
E
K
---
Y
-----
Q
K
P
F
-
K
P
L
I
S
G
V
K
-----
F
A
K
Y
--------------
N
D
I
S
S
V
-
E
K
L
---
V
-
N
-------------
E
K
T
C
A
I
I
L
E
-
S
V
Q
G
E
G
G
I
N
P
A
N
K
D
F
Y
K
A
L
R
K
L
C
D
E
K
D
I
L
L
I
A
D
E
I
Q
C
G
M
G
R
S
G
K
F
F
A
Y
E
H
A
Q
I
L
P
D
I
M
T
S
A
K
A
L
G
C
G
-
L
-
S
V
G
A
F
V
I
N
Q
K
V
A
S
-
N
S
L
E
A
G
D
----
H
G
S
T
Y
G
G
N
P
L
----
V
C
A
G
V
N
A
V
F
E
I
F
K
E
E
K
I
L
E
N
V
N
K
L
T
P
Y
L
E
Q
S
L
D
E
L
I
N
-
E
F
D
F
C
K
K
R
K
G
L
G
F
M
Q
G
L
S
L
----
D
----
K
SV
K
----------
V
A
--
K
--
V
I
Q
K
C
-
Q
-------------------------
E
N
A
L
L
L
I
S
----
C
G
E
N
-
D
L
R
F
L
P
P
L
I
L
Q
K
E
H
-
I
D
E
M
S
E
K
L
-
R
K
A
L
K
S
--------
40
PsiBlast_CBE
83.08
38%
-103
- C1 -
1VEF
2
ARGD_THET8
B:
[24-394]
-------
Y
N
K
H
D
L
L
I
--
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
---
R
Q
A
E
T
-----
L
M
A
M
P
-----
Q
T
L
--
P
T
P
M
R
GEFY
R
T
L
T
A
I
L
P
P
----
E
-
L
---
N
R
-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--
H
--------
T
-----
G
------
R
K
------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
---
Y
-----
R
E
P
F
-
L
P
L
V
E
P
V
E
-----
F
I
P
Y
--------------
N
D
V
E
A
L
-
K
R
A
---
V
-
D
-------------
E
E
T
A
A
V
I
L
E
-
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
-
S
M
P
K
-
G
G
----
H
G
T
T
F
G
G
N
P
L
----
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
---
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
----
E
--
K
----------
A
A
--
P
--
Y
I
A
R
L
E
K
-------------------------
E
H
R
V
L
A
L
Q
----
A
G
P
T
-
V
I
R
F
L
P
P
L
V
I
E
K
E
D
-
L
E
R
V
V
E
A
V
-
R
A
V
L
----------
19
PsiBlast_PDB
82.71
38%
-96
- C1 -
3NX3
3
ARGD_CAMJE
A:
[10-394]
--
H
I
I
P
T
Y
K
R
F
D
I
V
L
--
E
K
G
Q
G
V
Y
L
F
D
D
K
A
K
K
Y
L
D
F
S
S
G
I
G
V
C
A
L
G
Y
N
H
A
K
F
N
A
K
I
K
---
A
Q
V
D
K
-----
L
L
H
T
S
-----
N
L
Y
YN
E
N
I
A
A
----
A
A
K
N
L
A
K
A
S
----
A
-
L
---
E
R
-
V
F
F
T
N
S
G
T
E
S
I
E
G
A
M
K
T
A
R
K
--
Y
--------
A
-----
F
------
N
K
GVKG
G
-
Q
F
I
A
F
K
H
S
F
H
G
R
T
L
G
A
L
S
L
T
A
N
E
K
---
Y
-----
Q
K
P
F
-
K
P
L
I
S
G
V
K
-----
F
A
K
Y
--------------
N
D
I
S
S
V
-
E
K
L
---
V
-
N
-------------
E
K
T
C
A
I
I
L
E
-
S
V
Q
G
E
G
G
I
N
P
A
N
K
D
F
Y
K
A
L
R
K
L
C
D
E
K
D
I
L
L
I
A
D
E
I
Q
C
G
M
G
R
S
G
K
F
F
A
Y
E
H
A
Q
I
L
P
D
I
M
T
S
A
K
A
L
G
C
G
-
L
-
S
V
G
A
F
V
I
N
Q
K
V
A
S
N
S
L
E
A
-
G
D
----
H
G
S
T
Y
G
G
N
P
L
----
V
C
A
G
V
N
A
V
F
E
I
F
K
E
E
K
I
L
E
N
V
N
K
L
T
P
Y
L
E
Q
S
L
D
E
L
I
N
-
E
F
D
F
C
K
K
R
K
G
L
G
F
M
Q
G
L
S
L
----
D
----
K
--
S
----------
V
K
V
A
K
--
V
I
Q
K
C
-
Q
-------------------------
E
N
A
L
L
L
I
S
----
C
G
E
N
-
D
L
R
F
L
P
P
L
I
L
Q
K
E
H
-
I
D
E
M
S
E
K
L
-
R
K
A
L
K
S
--------
16
PsiBlast_PDB
82.69
38%
-102
- C1 -
1VEF
2
ARGD_THET8
A:
[24-394]
-------
Y
N
K
H
D
L
L
I
--
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
---
R
Q
A
E
T
-----
L
M
A
M
P
-----
Q
T
L
--
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
----
E
-
L
---
N
R
-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--
H
--------
T
-----
G
------
R
K
------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
---
Y
-----
R
E
P
F
-
L
P
L
V
E
P
V
E
-----
F
I
P
Y
--------------
N
D
V
E
A
L
-
K
R
A
---
V
-
D
-------------
E
E
T
A
A
V
I
L
E
-
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
-
S
M
P
K
-
G
G
----
H
G
T
T
F
G
G
N
P
L
----
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
---
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
----
E
--
K
----------
A
A
--
P
--
Y
I
A
R
L
E
K
-------------------------
E
H
R
V
L
A
L
Q
----
A
G
P
T
-
V
I
R
F
L
P
P
L
V
I
E
K
E
D
-
L
E
R
V
V
E
A
V
-
R
A
V
L
----------
38
PsiBlast_CBE
82.35
38%
-99
- C1 -
1WKH
2
ARGD_THET8
B:
[24-394]
-------
Y
N
K
H
D
L
L
I
--
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
---
R
Q
A
E
T
-----
L
M
A
M
P
-----
Q
T
L
--
P
T
P
M
R
GEFY
R
T
L
T
A
I
L
P
P
----
E
-
L
---
N
R
-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--
H
--------
T
-----
G
------
R
K
------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
---
Y
-----
R
E
P
F
-
L
P
L
V
E
P
V
E
-----
F
I
P
Y
--------------
N
D
V
E
A
L
-
K
R
A
---
V
-
D
-------------
E
E
T
A
A
V
I
L
E
-
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
-
S
M
P
K
-
G
G
----
H
G
T
T
F
G
G
N
P
L
----
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
---
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
----
E
--
K
----------
A
A
--
P
--
Y
I
A
R
L
E
K
-------------------------
E
H
R
V
L
A
L
Q
----
A
G
P
T
-
V
I
R
F
L
P
P
L
V
I
E
K
E
D
-
L
E
R
V
V
E
A
V
-
R
A
V
L
----------
103
HHSearch
82.23
39%
-102
* C1 *
1VEF
2
ARGD_THET8
A:
[24-394]
-------
Y
N
K
H
D
L
L
I
--
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
---
R
Q
A
E
T
-----
L
M
A
M
P
-----
Q
T
L
--
P
T
P
M
R
----
G
E
F
Y
R
T
L
T
A
----
I
-
L
PPE
L
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--
H
--------
T
-----
G
------
R
K
------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
---
Y
-----
R
E
P
F
-
L
P
L
V
E
P
V
E
-----
F
I
P
Y
--------------
N
D
V
E
A
L
-
K
R
A
---
V
-
D
-------------
E
E
T
A
A
V
I
L
E
-
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
-
S
M
P
K
-
G
G
----
H
G
T
T
F
G
G
N
P
L
----
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
---
S
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
----
E
--
K
----------
A
A
--
P
--
Y
I
A
R
L
-
E
K
------------------------
E
H
R
V
L
A
L
Q
----
A
G
P
T
-
V
I
R
F
L
P
P
L
V
I
E
K
E
D
-
L
E
R
V
V
E
A
V
-
R
A
V
L
----------
18
PsiBlast_PDB
82.04
38%
-101
- C1 -
1WKH
2
ARGD_THET8
A:
[24-394]
-------
Y
N
K
H
D
L
L
I
--
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
---
R
Q
A
E
T
-----
L
M
A
M
P
-----
Q
T
L
--
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
----
E
-
L
---
N
R
-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--
H
--------
T
-----
G
------
R
K
------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
---
Y
-----
R
E
P
F
-
L
P
L
V
E
P
V
E
-----
F
I
P
Y
--------------
N
D
V
E
A
L
-
K
R
A
---
V
-
D
-------------
E
E
T
A
A
V
I
L
E
-
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
-
S
M
P
K
-
G
G
----
H
G
T
T
F
G
G
N
P
L
----
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
---
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
----
E
--
K
----------
A
A
--
P
--
Y
I
A
R
L
E
K
-------------------------
E
H
R
V
L
A
L
Q
----
A
G
P
T
-
V
I
R
F
L
P
P
L
V
I
E
K
E
D
-
L
E
R
V
V
E
A
V
-
R
A
V
L
----------
17
PsiBlast_PDB
81.13
38%
-103
- C1 -
1WKG
2
ARGD_THET8
A:
[24-394]
-------
Y
N
K
H
D
L
L
I
--
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
---
R
Q
A
E
T
-----
L
M
A
M
P
-----
Q
T
L
--
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
----
E
-
L
---
N
R
-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--
H
--------
T
-----
G
------
R
K
------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
---
Y
-----
R
E
P
F
-
L
P
L
V
E
P
V
E
-----
F
I
P
Y
--------------
N
D
V
E
A
L
-
K
R
A
---
V
-
D
-------------
E
E
T
A
A
V
I
L
E
-
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
-
S
M
P
K
-
G
G
----
H
G
T
T
F
G
G
N
P
L
----
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
---
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
----
E
--
K
----------
A
A
--
P
--
Y
I
A
R
L
E
K
-------------------------
E
H
R
V
L
A
L
Q
----
A
G
P
T
-
V
I
R
F
L
P
P
L
V
I
E
K
E
D
-
L
E
R
V
V
E
A
V
-
R
A
V
L
----------
32
PsiBlast_CBE
79.96
40%
-86
- C1 -
4ADC
2
ASTC_ECOLI
D:
[14-399]
---
M
I
P
V
Y
A
P
A
P
F
I
P
--
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
A
H
P
E
L
R
E
A
L
N
---
E
Q
A
S
K
-----
F
W
H
T
G
-----
N
G
Y
TN
E
P
V
L
R
----
L
A
K
K
L
I
D
A
T
----
F
-
A
---
D
R
-
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
--
F
AHDRYG--
S
-----
H
------
K
S
------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
---
Y
-----
S
Q
D
F
-
A
P
L
P
A
D
I
R
-----
H
A
A
Y
--------------
N
D
I
N
S
A
-
S
A
L
---
I
-
D
-------------
D
S
T
C
A
V
I
V
E
-
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
-
V
M
T
V
-
G
T
----
H
G
T
T
Y
G
G
N
P
L
----
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
-
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
----
N
ADYA
G
--
Q
----------
A
K
--
Q
--
I
S
Q
E
A
-
A
-------------------------
K
A
G
V
M
V
L
I
----
A
G
G
N
-
V
V
R
F
A
P
A
L
N
V
S
E
E
E
-
V
T
T
G
L
D
R
F
-
A
A
A
C
E
H
--------
74
PsiBlast_CBE
79.89
33%
-103
- C1 -
4ZLV
6
?
B:
[43-433]
-
Q
Y
V
C
Q
N
Y
A
P
V
P
V
V
I
--
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
---
R
Q
A
E
R
-----
L
T
L
T
L
-----
R
A
F
--
G
N
D
V
T
----
G
P
A
C
R
F
M
A
E
MF--
G
-
Y
---
D
R
-
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
WA
Y
--------
E
-----
V
------
K
E
IPPDSA
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
---
C
-----
Y
N
N
F
-
G
P
F
T
P
G
F
E
-----
L
I
D
Y
--------------
D
D
V
G
A
L
-
E
E
A
---
L
K
D
-------------
P
N
V
A
A
F
F
V
E
-
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
-
V
L
K
P
-
G
T
----
H
G
S
T
F
G
G
N
P
L
----
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
K
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S---
D
--
A
----------
I
D
--
P
ND
V
V
M
K
L
-
K
-------------------------
E
N
G
I
L
S
K
P
----
T
R
G
R
-
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
I
-
K
S
F
L
----------
12
PsiBlast_PDB
79.81
40%
-87
- C1 -
4ADB
4
ASTC_ECOLI
A:
[14-399]
---
M
I
P
V
Y
A
P
A
P
F
I
P
--
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
A
H
P
E
L
R
E
A
L
N
---
E
Q
A
S
K
-----
F
W
H
T
G
-----
N
G
Y
TN
E
P
V
L
R
----
L
A
K
K
L
I
D
A
T
----
F
-
A
---
D
R
-
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
--
F
A
H
D
R
YG--
S
-----
H
------
K
S
------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
---
Y
-----
S
Q
D
F
-
A
P
L
P
A
D
I
R
-----
H
A
A
Y
--------------
N
D
I
N
S
A
-
S
A
L
---
I
-
D
-------------
D
S
T
C
A
V
I
V
E
-
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
-
V
M
T
V
-
G
T
----
H
G
T
T
Y
G
G
N
P
L
----
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
-
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
----
N
ADYA
G
--
Q
----------
A
K
--
Q
--
I
S
Q
E
A
-
A
-------------------------
K
A
G
V
M
V
L
I
----
A
G
G
N
-
V
V
R
F
A
P
A
L
N
V
S
E
E
E
-
V
T
T
G
L
D
R
F
-
A
A
A
C
E
H
--------
80
PsiBlast_CBE
79.69
33%
-104
- C1 -
2BYJ
2
OAT_HUMAN
A:
[55-436]
-------
Y
H
P
L
P
V
A
L
--
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
-----
L
T
L
T
S
-----
R
A
F
--
Y
N
N
V
L
----
G
E
Y
E
E
Y
I
T
K
L
---
F
-
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--
W
G
Y
TVKGIQ
K
-----
Y
------
K
A
------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
---
S
-----
Y
D
G
F
-
G
P
F
M
P
G
F
D
-----
I
I
P
Y
--------------
N
D
L
P
A
L
E
R
A
L
---
Q
-
D
-------------
P
N
V
A
A
F
M
V
E
-
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
-
T
I
K
P
-
G
E
----
H
G
S
T
Y
G
G
N
P
L
----
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
---
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
----
E
--
T
KDWD------
A
W
--
K
--
V
C
L
R
L
-
R
-------------------------
D
N
G
L
L
A
K
P
----
T
H
G
D
-
I
I
R
F
A
P
P
L
V
I
K
E
D
E
-
L
R
E
S
I
E
I
I
-
N
K
T
I
----------
90
PsiBlast_CBE
79.42
33%
-106
- C1 -
1GBN
2
OAT_HUMAN
A:
[18-399]
-------
Y
H
P
L
P
V
A
L
--
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
-----
L
T
L
T
S
-----
R
A
F
--
Y
N
N
V
L
----
G
E
Y
E
E
Y
I
T
K
L
---
F
-
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--
W
G
Y
TVKGIQ
K
-----
Y
------
K
A
------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
---
S
-----
Y
D
G
F
-
G
P
F
M
P
G
F
D
-----
I
I
P
Y
--------------
N
D
L
P
A
L
E
R
A
L
---
Q
-
D
-------------
P
N
V
A
A
F
M
V
E
-
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
-
T
I
K
P
-
G
E
----
H
G
S
T
Y
G
G
N
P
L
----
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
---
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
----
E
--
T
KDWD------
A
W
--
K
--
V
C
L
R
L
-
R
-------------------------
D
N
G
L
L
A
K
P
----
T
H
G
D
-
I
I
R
F
A
P
P
L
V
I
K
E
D
E
-
L
R
E
S
I
E
I
I
-
N
K
T
I
----------
34
PsiBlast_CBE
79.26
40%
-88
- C1 -
4ADC
4
ASTC_ECOLI
B:
[14-399]
---
M
I
P
V
Y
A
P
A
P
F
I
P
--
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
A
H
P
E
L
R
E
A
L
N
---
E
Q
A
S
K
-----
F
W
H
T
G
-----
N
G
Y
TN
E
P
V
L
R
----
L
A
K
K
L
I
D
A
T
----
F
-
A
---
D
R
-
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
--
F
AHDRYG--
S
-----
H
------
K
S
------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
---
Y
-----
S
Q
D
F
-
A
P
L
P
A
D
I
R
-----
H
A
A
Y
--------------
N
D
I
N
S
A
-
S
A
L
---
I
-
D
-------------
D
S
T
C
A
V
I
V
E
-
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
-
V
M
T
V
-
G
T
----
H
G
T
T
Y
G
G
N
P
L
----
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
-
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
----
N
ADYA
G
--
Q
----------
A
K
--
Q
--
I
S
Q
E
A
-
A
-------------------------
K
A
G
V
M
V
L
I
----
A
G
G
N
-
V
V
R
F
A
P
A
L
N
V
S
E
E
E
-
V
T
T
G
L
D
R
F
-
A
A
A
C
E
H
--------
39
PsiBlast_CBE
79.01
38%
-98
- C1 -
1WKG
2
ARGD_THET8
B:
[24-394]
-------
Y
N
K
H
D
L
L
I
--
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
---
R
Q
A
E
T
-----
L
M
A
M
P
-----
Q
T
L
--
P
T
P
M
R
GEFY
R
T
L
T
A
I
L
P
P
----
E
-
L
---
N
R
-
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
--
H
--------
T
-----
G
------
R
K
------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
---
Y
-----
R
E
P
F
-
L
P
L
V
E
P
V
E
-----
F
I
P
Y
--------------
N
D
V
E
A
L
-
K
R
A
---
V
-
D
-------------
E
E
T
A
A
V
I
L
E
-
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
-
S
M
P
K
-
G
G
----
H
G
T
T
F
G
G
N
P
L
----
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
---
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
----
K
----
E
--
K
----------
A
A
--
P
--
Y
I
A
R
L
E
K
-------------------------
E
H
R
V
L
A
L
Q
----
A
G
P
T
-
V
I
R
F
L
P
P
L
V
I
E
K
E
D
-
L
E
R
V
V
E
A
V
-
R
A
V
L
----------
94
PsiBlast_CBE
78.88
33%
-105
- C1 -
1OAT
1
OAT_HUMAN
C:
[55-436]
-------
Y
H
P
L
P
V
A
L
--
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
-----
L
T
L
T
S
-----
R
A
F
--
Y
N
N
V
L
----
G
E
Y
E
E
Y
I
T
K
L---
F
-
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--
W
GYTVKGIQ
K
-----
Y
------
K
A
------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
---
S
-----
Y
D
G
F
-
G
P
F
M
P
G
F
D
-----
I
I
P
Y
--------------
N
D
L
P
A
L
E
R
A
L
---
Q
-
D
-------------
P
N
V
A
A
F
M
V
E
-
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
-
T
I
K
P
-
G
E
----
H
G
S
T
Y
G
G
N
P
L
----
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
---
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
----
E
--
T
KDWD------
A
W
--
K
--
V
C
L
R
L
-
R
-------------------------
D
N
G
L
L
A
K
P
----
T
H
G
D
-
I
I
R
F
A
P
P
L
V
I
K
E
D
E
-
L
R
E
S
I
E
I
I
-
N
K
T
I
----------
79
PsiBlast_CBE
78.60
33%
-104
- C1 -
2BYJ
2
OAT_HUMAN
B:
[55-436]
-------
Y
H
P
L
P
V
A
L
--
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
-----
L
T
L
T
S
-----
R
A
F
--
Y
N
N
V
L
----
G
E
Y
E
E
Y
I
T
K
L---
F
-
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--
W
GYTVKGIQ
K
-----
Y
------
K
A
------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
---
S
-----
Y
D
G
F
-
G
P
F
M
P
G
F
D
-----
I
I
P
Y
--------------
N
D
L
P
A
L
E
R
A
L
---
Q
-
D
-------------
P
N
V
A
A
F
M
V
E
-
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
-
T
I
K
P
-
G
E
----
H
G
S
T
Y
G
G
N
P
L
----
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
---
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
----
E
--
T
KDWD------
A
W
--
K
--
V
C
L
R
L
-
R
-------------------------
D
N
G
L
L
A
K
P
----
T
H
G
D
-
I
I
R
F
A
P
P
L
V
I
K
E
D
E
-
L
R
E
S
I
E
I
I
-
N
K
T
I
----------
78
PsiBlast_CBE
78.42
33%
-104
- C1 -
2BYJ
1
OAT_HUMAN
C:
[55-436]
-------
Y
H
P
L
P
V
A
L
--
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
-----
L
T
L
T
S
-----
R
A
F
--
Y
N
N
V
L
----
G
E
Y
E
E
Y
I
T
K
L---
F
-
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--
W
GYTVKGIQ
K
-----
Y
------
K
A
------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
---
S
-----
Y
D
G
F
-
G
P
F
M
P
G
F
D
-----
I
I
P
Y
--------------
N
D
L
P
A
L
E
R
A
L
---
Q
-
D
-------------
P
N
V
A
A
F
M
V
E
-
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
-
T
I
K
P
-
G
E
----
H
G
S
T
Y
G
G
N
P
L
----
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
---
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
----
E
--
T
KDWD------
A
W
--
K
--
V
C
L
R
L
-
R
-------------------------
D
N
G
L
L
A
K
P
----
T
H
G
D
-
I
I
R
F
A
P
P
L
V
I
K
E
D
E
-
L
R
E
S
I
E
I
I
-
N
K
T
I
----------
75
PsiBlast_CBE
78.29
33%
-101
- C1 -
4ZLV
5
?
A:
[43-433]
-
Q
Y
V
C
Q
N
Y
A
P
V
P
V
V
I
--
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
---
R
Q
A
E
R
-----
L
T
L
T
L
-----
R
A
F
--
G
N
D
V
T
----
G
P
A
C
R
F
M
A
E
M
F
--
G
-
Y
---
D
R
-
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
--------
E
-----
V
------
K
E
IPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
---
C
-----
Y
N
N
F
-
G
P
F
T
P
G
F
E
-----
L
I
D
Y
--------------
D
D
V
G
A
L
-
E
E
A
---
L
K
D
-------------
P
N
V
A
A
F
F
V
E
-
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
-
V
L
K
P
-
G
T
----
H
G
S
T
F
G
G
N
P
L
----
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
K
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S---
D
--
A
----------
I
D
--
P
N
D
V
V
M
K
L
-
K
-------------------------
E
N
G
I
L
S
K
P
----
T
R
G
R
-
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
I
-
K
S
F
L
----------
93
PsiBlast_CBE
78.21
33%
-104
- C1 -
2OAT
2
OAT_HUMAN
A:
[55-436]
-------
Y
H
P
L
P
V
A
L
--
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
-----
L
T
L
T
S
-----
R
A
F
--
Y
N
N
V
L
----
G
E
Y
E
E
Y
I
T
K
L
---
F
-
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--
W
G
Y
TVKGIQ
K
-----
Y
------
K
A
------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
---
S
-----
Y
D
G
F
-
G
P
F
M
P
G
F
D
-----
I
I
P
Y
--------------
N
D
L
P
A
L
E
R
A
L
---
Q
-
D
-------------
P
N
V
A
A
F
M
V
E
-
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
-
T
I
K
P
-
G
E
----
H
G
S
T
Y
G
G
N
P
L
----
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
---
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
----
E
--
T
KDWD------
A
W
--
K
--
V
C
L
R
L
-
R
-------------------------
D
N
G
L
L
A
K
P
----
T
H
G
D
-
I
I
R
F
A
P
P
L
V
I
K
E
D
E
-
L
R
E
S
I
E
I
I
-
N
K
T
I
----------
73
PsiBlast_CBE
78.14
33%
-101
- C1 -
4ZWM
12
?
A:
[43-433]
-
Q
Y
V
C
Q
N
Y
A
-
V
P
V
V
I
--
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
---
R
Q
A
E
R
-----
L
T
L
T
L
-----
R
A
F
--
G
N
D
V
T
----
G
P
A
C
R
F
M
A
E
M
F
--
G
-
Y
---
D
R
-
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
--------
E
-----
V
------
K
E
IPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
---
C
-----
Y
N
N
F
-
G
P
F
T
P
G
F
E
-----
L
I
D
Y
--------------
D
D
V
G
A
L
-
E
E
A
---
L
K
D
-------------
P
N
V
A
A
F
F
V
E
-
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
-
V
L
K
P
-
G
T
----
H
G
S
T
F
G
G
N
P
L
----
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
K
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S---
D
--
A
----------
I
D
--
P
N
D
V
V
M
K
L
-
K
-------------------------
E
N
G
I
L
S
K
P
----
T
R
G
R
-
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
I
-
K
S
F
L
----------
72
PsiBlast_CBE
78.11
33%
-99
- C1 -
4ZWM
10
?
B:
[43-433]
-
Q
Y
V
C
Q
N
Y
A
-
V
P
V
V
I
--
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
---
R
Q
A
E
R
-----
L
T
L
T
L
-----
R
A
F
--
G
N
D
V
T
----
G
P
A
C
R
F
M
A
E
M
F
--
G
-
Y
---
D
R
-
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
--------
E
-----
V
------
K
E
IPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
---
C
-----
Y
N
N
F
-
G
P
F
T
P
G
F
E
-----
L
I
D
Y
--------------
D
D
V
G
A
L
-
E
E
A
---
L
K
D
-------------
P
N
V
A
A
F
F
V
E
-
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
-
V
L
K
P
-
G
T
----
H
G
S
T
F
G
G
N
P
L
----
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
K
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S---
D
--
A
----------
I
D
--
P
N
D
V
V
M
K
L
-
K
-------------------------
E
N
G
I
L
S
K
P
----
T
R
G
R
-
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
I
-
K
S
F
L
----------
96
PsiBlast_CBE
77.62
33%
-105
- C1 -
1OAT
2
OAT_HUMAN
A:
[55-436]
-------
Y
H
P
L
P
V
A
L
--
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
-----
L
T
L
T
S
-----
R
A
F
--
Y
N
N
V
L
----
G
E
Y
E
E
Y
I
T
K
L
---
F
-
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--
W
G
Y
TVKGIQ
K
-----
Y
------
K
A
------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
---
S
-----
Y
D
G
F
-
G
P
F
M
P
G
F
D
-----
I
I
P
Y
--------------
N
D
L
P
A
L
E
R
A
L
---
Q
-
D
-------------
P
N
V
A
A
F
M
V
E
-
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
-
T
I
K
P
-
G
E
----
H
G
S
T
Y
G
G
N
P
L
----
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
---
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
----
E
--
T
KDWD------
A
W
--
K
--
V
C
L
R
L
-
R
-------------------------
D
N
G
L
L
A
K
P
----
T
H
G
D
-
I
I
R
F
A
P
P
L
V
I
K
E
D
E
-
L
R
E
S
I
E
I
I
-
N
K
T
I
----------
95
PsiBlast_CBE
77.49
33%
-103
- C1 -
1OAT
2
OAT_HUMAN
B:
[55-436]
-------
Y
H
P
L
P
V
A
L
--
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
-----
L
T
L
T
S
-----
R
A
F
--
Y
N
N
V
L
----
G
E
Y
E
E
Y
I
T
K
L---
F
-
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--
W
GYTVKGIQ
K
-----
Y
------
K
A
------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
---
S
-----
Y
D
G
F
-
G
P
F
M
P
G
F
D
-----
I
I
P
Y
--------------
N
D
L
P
A
L
E
R
A
L
---
Q
-
D
-------------
P
N
V
A
A
F
M
V
E
-
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
-
T
I
K
P
-
G
E
----
H
G
S
T
Y
G
G
N
P
L
----
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
---
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
----
E
--
T
KDWD------
A
W
--
K
--
V
C
L
R
L
-
R
-------------------------
D
N
G
L
L
A
K
P
----
T
H
G
D
-
I
I
R
F
A
P
P
L
V
I
K
E
D
E
-
L
R
E
S
I
E
I
I
-
N
K
T
I
----------
70
PsiBlast_CBE
77.13
33%
-100
- C1 -
4NOG
6
?
B:
[28-418]
-
Q
Y
V
C
Q
N
Y
A
P
V
P
V
V
I
--
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
---
R
Q
A
E
R
-----
L
T
L
T
L
-----
R
A
F
--
G
N
D
V
T
----
G
P
A
C
R
F
M
A
E
M
F
--
G
-
Y
---
D
R
-
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
--------
E
-----
V
------
K
E
IPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
---
C
-----
Y
N
N
F
-
G
P
F
T
P
G
F
E
-----
L
I
D
Y
--------------
D
D
V
G
A
L
-
E
E
A
---
L
K
D
-------------
P
N
V
A
A
F
F
V
E
-
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
-
V
L
K
P
-
G
T
----
H
G
S
T
F
G
G
N
P
L
----
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
K
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S---
D
--
A
----------
I
D
--
P
N
D
V
V
M
K
L
-
K
-------------------------
E
N
G
I
L
S
K
P
----
T
R
G
R
-
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
I
-
K
S
F
L
----------
99
PsiBlast_CBE
76.71
33%
-104
- C1 -
2BYL
2
OAT_HUMAN
A:
[58-437]
----------
L
P
V
A
L
--
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
-----
L
T
L
T
S
-----
R
A
F
--
Y
N
N
V
L
----
G
E
Y
E
E
Y
I
T
K
L
---
F
-
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--
W
G
Y
TVKGIQ
K
-----
Y
------
K
A
------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
---
S
-----
Y
D
G
F
-
G
P
F
M
P
G
F
D
-----
I
I
P
Y
--------------
N
D
L
P
A
L
E
R
A
L
---
Q
-
D
-------------
P
N
V
A
A
F
M
V
E
-
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
-
T
I
K
P
-
G
E
----
H
F
S
T
Y
G
G
N
P
L
----
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
---
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
----
E
--
T
KDWD------
A
W
--
K
--
V
C
L
R
L
-
R
-------------------------
D
N
G
L
L
A
K
P
----
T
H
G
D
-
I
I
R
F
A
P
P
L
V
I
K
E
D
E
-
L
R
E
S
I
E
I
I
N
K
T
I
L
----------
28
PsiBlast_CBE
76.51
41%
-84
- C1 -
4JEY
13
ARGD_SALTY
B:
[33-408]
----
L
P
V
Y
A
P
A
D
F
I
P
--
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
---
S
Q
G
E
T
-----
L
W
H
T
S
-----
N
V
F
TN
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
----
F
-
A
---
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
--
Y
--------
A
-----
C
V
R
HSPF
K
T
------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
---
Y
-----
S
D
G
F
-
G
P
K
P
A
D
I
I
-----
H
V
P
F
--------------
N
D
L
H
A
V
-
K
A
V
---
M
-
D
-------------
D
H
T
C
A
V
V
V
E
-
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
-
A
F
H
V
-
G
S
----
H
G
S
T
Y
G
G
N
P
L
----
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
-
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
----
G
--
R
----------
A
R
--
D
--
F
L
Y
A
G
-
A
-------------------------
E
A
G
V
M
V
L
N
----
A
G
A
D
-
V
M
R
F
A
P
S
L
V
V
E
E
A
D
-
I
H
E
G
M
------------------
97
PsiBlast_CBE
76.43
33%
-106
- C1 -
2BYL
1
OAT_HUMAN
C:
[58-437]
----------
L
P
V
A
L
--
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
-----
L
T
L
T
S
-----
R
A
F
--
Y
N
N
V
L
----
G
E
Y
E
E
Y
I
T
K
L---
F
-
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--
W
GYTVKGIQ
K
-----
Y
------
K
A
------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
---
S
-----
Y
D
G
F
-
G
P
F
M
P
G
F
D
-----
I
I
P
Y
--------------
N
D
L
P
A
L
E
R
A
L
---
Q
-
D
-------------
P
N
V
A
A
F
M
V
E
-
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
-
T
I
K
P
-
G
E
----
H
F
S
T
Y
G
G
N
P
L
----
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
---
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
----
E
--
T
KDWD------
A
W
--
K
--
V
C
L
R
L
-
R
-------------------------
D
N
G
L
L
A
K
P
----
T
H
G
D
-
I
I
R
F
A
P
P
L
V
I
K
E
D
E
-
L
R
E
S
I
E
I
I
N
K
T
I
L
----------
71
PsiBlast_CBE
76.24
33%
-101
- C1 -
4NOG
3
?
A:
[28-418]
-
Q
Y
V
C
Q
N
Y
A
P
V
P
V
V
I
--
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
C
H
P
R
V
I
A
A
L
C
---
R
Q
A
E
R
-----
L
T
L
T
L
-----
R
A
F
--
G
N
D
V
T
----
G
P
A
C
R
F
M
A
E
M
F
--
G
-
Y
---
D
R
-
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
Y
--------
E
-----
V
------
K
E
IPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
---
C
-----
Y
N
N
F
-
G
P
F
T
P
G
F
E
-----
L
I
D
Y
--------------
D
D
V
G
A
L
-
E
E
A
---
L
K
D
-------------
P
N
V
A
A
F
F
V
E
-
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
-
V
L
K
P
-
G
T
----
H
G
S
T
F
G
G
N
P
L
----
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
Y
G
K
V
P
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
----
D
S---
D
--
A
----------
I
D
--
P
N
D
V
V
M
K
L
-
K
-------------------------
E
N
G
I
L
S
K
P
----
T
R
G
R
-
V
M
R
F
I
P
P
L
V
I
T
D
E
E
H
R
D
A
T
T
R
I
I
-
K
S
F
L
----------
22
PsiBlast_CBE
75.99
42%
-83
- C1 -
4JEW
13
ARGD_SALTY
B:
[32-408]
---
I
L
P
V
Y
A
P
A
D
F
I
P
--
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
---
S
Q
G
E
T
-----
L
W
H
T
S
-----
N
V
F
TN
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
----
F
-
A
---
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
--
Y
--------
A
-----
C
V
R
HSPF
K
T
------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
---
Y
-----
S
D
G
F
-
G
P
K
P
A
D
I
I
-----
H
V
P
F
--------------
N
D
L
H
A
V
-
K
A
V
---
M
-
D
-------------
D
H
T
C
A
V
V
V
E
-
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
-
A
F
H
V
-
G
S
----
H
G
S
T
Y
G
G
N
P
L
----
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
-
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
----
G
--
R
----------
A
R
--
D
--
F
L
Y
A
G
-
A
-------------------------
E
A
G
V
M
V
L
N
----
A
G
A
D
-
V
M
R
F
A
P
S
L
V
V
E
E
A
D
-
I
H
E
G
M
------------------
98
PsiBlast_CBE
75.69
33%
-103
- C1 -
2BYL
2
OAT_HUMAN
B:
[58-437]
----------
L
P
V
A
L
--
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
C
H
P
K
I
V
N
A
L
K
---
S
Q
V
D
K
-----
L
T
L
T
S
-----
R
A
F
--
Y
N
N
V
L
----
G
E
Y
E
E
Y
I
T
K
L---
F
-
N
---
Y
H
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
--
W
GYTVKGIQ
K
-----
Y
------
K
A
------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
---
S
-----
Y
D
G
F
-
G
P
F
M
P
G
F
D
-----
I
I
P
Y
--------------
N
D
L
P
A
L
E
R
A
L
---
Q
-
D
-------------
P
N
V
A
A
F
M
V
E
-
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
-
T
I
K
P
-
G
E
----
H
F
S
T
Y
G
G
N
P
L
----
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
---
D
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
----
K
----
E
--
T
KDWD------
A
W
--
K
--
V
C
L
R
L
-
R
-------------------------
D
N
G
L
L
A
K
P
----
T
H
G
D
-
I
I
R
F
A
P
P
L
V
I
K
E
D
E
-
L
R
E
S
I
E
I
I
N
K
T
I
L
----------
24
PsiBlast_CBE
75.31
42%
-83
- C1 -
2PB0
5
ARGD_SALTY
B:
[33-408]
----
L
P
V
Y
A
P
A
D
F
I
P
--
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
---
S
Q
G
E
T
-----
L
W
H
T
S
-----
N
V
F
TN
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
----
F
-
A
---
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
--
Y
--------
A
-----
C
V
R
HSPF
K
T
------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
---
Y
-----
S
D
G
F
-
G
P
K
P
A
D
I
I
-----
H
V
P
F
--------------
N
D
L
H
A
V
-
K
A
V
---
M
-
D
-------------
D
H
T
C
A
V
V
V
E
-
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
-
A
F
H
V
-
G
S
----
H
G
S
T
Y
G
G
N
P
L
----
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
-
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
----
G
--
R
----------
A
R
--
D
--
F
L
Y
A
G
-
A
-------------------------
E
A
G
V
M
V
L
N
----
A
G
A
D
-
V
M
R
F
A
P
S
L
V
V
E
E
A
D
-
I
H
E
G
M
------------------
10
PsiBlast_PDB
74.74
41%
-87
- C1 -
4JEZ
14
ARGD_SALTY
A:
[39-408]
----------
A
D
F
I
P
--
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
---
S
Q
G
E
T
-----
L
W
H
T
S
-----
R
V
F
TN
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
----
F
-
A
---
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
--
Y
--------
A
-----
C
V
R
HSPF
K
T
------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
---
Y
-----
S
D
G
F
-
G
P
K
P
A
D
I
I
-----
H
V
P
F
--------------
N
D
L
H
A
V
-
K
A
V
---
M
-
D
-------------
D
H
T
C
A
V
V
V
E
-
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
-
A
F
----------
G
S
T
Y
G
G
N
P
L
----
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
-
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
----
G
--
R
----------
A
R
--
D
--
F
L
Y
A
G
-
A
-------------------------
E
A
G
V
M
V
L
N
----
A
G
A
D
-
V
M
R
F
A
P
S
L
V
V
E
E
A
D
-
I
H
E
G
M
------------------
23
PsiBlast_CBE
74.49
42%
-83
- C1 -
2PB2
5
ARGD_SALTY
B:
[33-408]
----
L
P
V
Y
A
P
A
D
F
I
P
--
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
---
S
Q
G
E
T
-----
L
W
H
T
S
-----
N
V
F
TN
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
----
F
-
A
---
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
--
Y
--------
A
-----
C
V
R
HSPF
K
T
------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
---
Y
-----
S
D
G
F
-
G
P
K
P
A
D
I
I
-----
H
V
P
F
--------------
N
D
L
H
A
V
-
K
A
V
---
M
-
D
-------------
D
H
T
C
A
V
V
V
E
-
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
-
A
F
-----------
S
T
Y
G
G
N
P
L
----
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
-
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
----
G
--
R
----------
A
R
--
D
--
F
L
Y
A
G
-
A
-------------------------
E
A
G
V
M
V
L
N
----
A
G
A
D
-
V
M
R
F
A
P
S
L
V
V
E
E
A
D
-
I
H
E
G
M
------------------
9
PsiBlast_PDB
74.43
41%
-86
- C1 -
4JF1
9
ARGD_SALTY
A:
[32-408]
---
I
L
P
V
Y
A
P
A
D
F
I
P
--
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
---
S
Q
G
E
T
-----
L
W
H
T
S
-----
N
V
F
TN
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
----
F
-
A
---
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
--
Y
--------
A
-----
C
V
R
HSPF
K
T
------
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
---
Y
-----
S
D
G
F
-
G
P
K
P
A
D
I
I
-----
H
V
P
F
--------------
N
D
L
H
A
V
-
K
A
V
---
M
-
D
-------------
D
H
T
C
A
V
V
V
E
-
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
-
A
F
-----------
S
T
Y
G
G
N
P
L
----
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
-
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
----
G
--
R
----------
A
R
--
D
--
F
L
Y
A
G
-
A
-------------------------
E
A
G
V
M
V
L
N
----
A
G
A
D
-
V
M
R
F
A
P
S
L
V
V
E
E
A
D
-
I
H
E
G
M
------------------
25
PsiBlast_CBE
74.31
42%
-86
- C1 -
4JEX
17
ARGD_SALTY
B:
[38-408]
-----------
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
---
S
Q
G
E
T
-----
L
W
H
T
S
-----
N
V
F
TN
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
----
F
-
A
---
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
--
Y
--------
A
-----
C
V
R
HSPF
K
T
------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
---
Y
-----
S
D
G
F
-
G
P
K
P
A
D
I
I
-----
H
V
P
F
--------------
N
D
L
H
A
V
-
K
A
V
---
M
-
D
-------------
D
H
T
C
A
V
V
V
E
-
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
-
A
F
----------
G
S
T
Y
G
G
N
P
L
----
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
-
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
----
G
--
R
----------
A
R
--
D
--
F
L
Y
A
G
-
A
-------------------------
E
A
G
V
M
V
L
N
----
A
G
A
D
-
V
M
R
F
A
P
S
L
V
V
E
E
A
D
-
I
H
E
G
M
------------------
26
PsiBlast_CBE
74.30
41%
-82
- C1 -
4JF1
9
ARGD_SALTY
B:
[33-408]
----
L
P
V
Y
A
P
A
D
F
I
P
--
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
---
S
Q
G
E
T
-----
L
W
H
T
S
-----
N
V
F
TN
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
----
F
-
A
---
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
--
Y
--------
A
-----
C
V
R
HSPF
K
T
------
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
---
Y
-----
S
D
G
F
-
G
P
K
P
A
D
I
I
-----
H
V
P
F
--------------
N
D
L
H
A
V
-
K
A
V
---
M
-
D
-------------
D
H
T
C
A
V
V
V
E
-
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
-
A
F
H
V
-
G
S
----
H
G
S
T
Y
G
G
N
P
L
----
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
-
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
----
G
--
R
----------
A
R
--
D
--
F
L
Y
A
G
-
A
-------------------------
E
A
G
V
M
V
L
N
----
A
G
A
D
-
V
M
R
F
A
P
S
L
V
V
E
E
A
D
-
I
H
E
G
M
------------------
8
PsiBlast_PDB
73.53
42%
-86
- C1 -
4JEX
17
ARGD_SALTY
A:
[39-408]
------------
A
D
F
IP
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
---
S
Q
G
E
T
-----
L
W
H
T
S
-----
N
V
F
TN
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
----
F
-
A
---
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
--
Y
--------
A
-----
C
V
R
HSPF
K
T
------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
---
Y
-----
S
D
G
F
-
G
P
K
P
A
D
I
I
-----
H
V
P
F
--------------
N
D
L
H
A
V
-
K
A
V
---
M
-
D
-------------
D
H
T
C
A
V
V
V
E
-
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
-
A
F
----------
G
S
T
Y
G
G
N
P
L
----
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
-
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
----
G
--
R
----------
A
R
--
D
--
F
L
Y
A
G
-
A
-------------------------
E
A
G
V
M
V
L
N
----
A
G
A
D
-
V
M
R
F
A
P
S
L
V
V
E
E
A
D
-
I
H
E
G
M
------------------
27
PsiBlast_CBE
72.76
41%
-83
- C1 -
4JEZ
13
ARGD_SALTY
B:
[33-408]
----
L
P
V
Y
A
P
A
D
F
I
P
--
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
---
S
Q
G
E
T
-----
L
W
H
T
S
-----
R
V
F
TN
E
P
A
L
R
----
L
G
R
K
L
I
D
A
T
----
F
-
A
---
E
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
--
Y
--------
A
-----
C
V
R
HSPF
K
T
------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
---
Y
-----
S
D
G
F
-
G
P
K
P
A
D
I
I
-----
H
V
P
F
--------------
N
D
L
H
A
V
-
K
A
V
---
M
-
D
-------------
D
H
T
C
A
V
V
V
E
-
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
-
A
F
----------
G
S
T
Y
G
G
N
P
L
----
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
-
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
PKY
K
----
G
--
R
----------
A
R
--
D
--
F
L
Y
A
G
-
A
-------------------------
E
A
G
V
M
V
L
N
----
A
G
A
D
-
V
M
R
F
A
P
S
L
V
V
E
E
A
D
-
I
H
E
G
M
------------------
49
PsiBlast_CBE
67.14
35%
-97
- C1 -
2EO5
3
?
A:
[24-416]
----------
F
P
L
V
I
--
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
-
W
P
S
H
-
P
E
V
I
K
I
G
I
E
Q
M
Q
K
-----
L
A
H
A
A
ANDFY
N
I
P
--
Q
L
E
L
A
----
K
K
L
V
T
Y
S
P
G
----
N
-
F
---
Q
K
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
-
K
--
N
--------
T
-----
G
------
R
K
------
Y
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
S
K
A
---
V
-----
Q
R
S
I
V
G
P
F
M
P
G
V
I
-----
H
V
P
Y
PNPYRNPWHINGYE
N
P
S
E
L
V
-
N
R
V
---
I
-
E
F
I
E
DYIFVNLVPP
E
E
V
A
G
I
F
F
E
-
P
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
-
P
I
G
A
T
I
F
R
K
D
L
---
D
F
K
-----------
T
F
G
G
N
A
L
----
A
C
A
I
G
S
K
V
I
D
I
V
K
D
--
L
L
P
H
V
N
E
I
G
K
I
F
A
E
E
L
Q
G
L
A
D
-------
D
V
R
G
I
G
L
A
W
G
L
E
Y
NE--
K
----
K
--
V
----------
R
D
--
R
--
I
I
G
E
S
-
F
-------------------------
K
R
G
L
L
L
L
P
----
A
G
R
S
-
A
I
R
V
I
P
P
L
V
I
S
E
E
E
-
A
K
Q
G
L
D
I
L
-
K
K
V
I
K
---------
76
PsiBlast_CBE
66.74
34%
-91
- C1 -
4PPM
3
?
B:
[421-846]
------------------
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
N
P
Q
P
V
V
N
A
L
K
---
N
Y
L
D
A
QGPNF
I
Q
Y
I
S
-----
I
P
E
--
Q
T
A
K
L
----
A
E
V
L
C
R
L
A
P
----
G
-
N
---
M
G
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
--
S
--------
T
-----
G
------
K
P
------
G
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
R
D
K
---
H
-----
R
R
Y
F
-
T
P
L
L
D
A
M
V
-----
E
V
P
F
--------------
G
D
L
A
A
L
-
R
E
A
---
L
-
N
R------------
E
D
V
G
A
L
M
I
E
-
P
I
Q
G
E
G
G
V
H
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
-
L
I
P
I
G
A
T
L
C
R
A
D
L
W
Q
K
A
Y
G
T
-
A
D
RFLV
H
S
S
T
Y
G
G
G
N
L
ASVV
A
L
S
A
L
R
E
I
-
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
---
Y
F
K
Q
A
L
S
E
I
A
A
-
R
Y
P
F
V
S
E
V
R
G
R
G
L
M
L
G
I
Q
F
----
D
--------WHTTWKFL--
P
D
--
P
--
V
Q
A
H
L
-
R
AAMDRMEQALGEMFCMKFVTKLCQD
H
K
I
L
T
F
I
T
----
A
N
S
S
T
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
-
I
D
R
F
V
G
A
F
-
A
T
V
C
E
---------
77
PsiBlast_CBE
64.11
34%
-90
- C1 -
4PPM
3
?
A:
[421-846]
------------------
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
N
P
Q
P
V
V
N
A
L
K
---
N
Y
L
D
A
QGPNF
I
Q
Y
I
S
-----
I
P
E
--
Q
T
A
K
L
----
A
E
V
L
C
R
L
A
P
----
G
-
N
---
M
G
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
--
S
--------
T
-----
G
------
K
P
------
G
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
R
D
K
---
H
-----
R
R
Y
F
-
T
P
L
L
D
A
M
V
-----
E
V
P
F
--------------
G
D
L
A
A
L
-
R
E
A
---
L
-
N
R------------
E
D
V
G
A
L
M
I
E
-
P
I
Q
G
E
G
G
V
H
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
-
L
I
P
I
G
A
T
L
C
R
A
D
L
W
Q
K
A
Y
G
T
-
A
D
RFLV
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
-
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
---
Y
F
K
Q
A
L
S
E
I
A
A
-
R
Y
P
F
V
S
E
V
R
G
R
G
L
M
L
G
I
Q
F
----
D
----
Q
--
A
H
T
T
W
K
F
L---
P
D
--
P
--
V
Q
A
H
L
-
R
A
A
M
D
R
M
E
Q
A
L
G
E
M
F
C
M
K
F
V
T
K
L
C
Q
D
H
K
I
L
T
F
I
T
----
A
N
S
S
T
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
-
I
D
R
F
V
G
A
F
-
A
T
V
C
E
---------
120
HHSearch
58.94
31%
-83
- C1 -
1ZOD
4
DGDA_BURCE
A:
[25-432]
----------
E
P
M
I
I
--
E
R
A
K
G
S
F
V
Y
D
A
D
G
R
A
I
L
D
F
T
S
G
Q
M
S
A
V
L
G
H
C
H
P
E
I
V
S
V
I
G
---
E
Y
A
G
K
-----
L
D
H
L
F
-----
S
E
M
--
L
S
R
P
V
----
V
D
L
A
T
R
L
A
N
----
I
T
P
PG-
L
D
R
A
L
L
L
S
T
G
A
E
S
N
E
A
A
I
R
M
A
K
L
--
V
--------
T
-----
G
------
K
Y
------
E
I
V
G
F
A
Q
S
W
H
G
M
T
G
A
A
A
S
A
T
Y
S
A
G
RKG
V
GPAAV
G
S
F
A
-
I
P
A
P
F
T
Y
R
PRFER
N
G
A
Y
--------------
D
Y
L
A
E
L
-
D
Y
A
F
D
L
I
-
D
R
Q
SS---------
G
N
L
A
A
F
I
A
E
-
P
I
L
S
S
G
G
I
I
E
L
P
D
G
Y
M
A
A
L
K
R
K
C
E
A
R
G
M
L
L
I
L
D
E
A
Q
T
G
V
G
R
T
G
T
M
F
A
C
Q
R
D
G
V
T
P
D
I
L
T
L
S
K
T
L
G
A
G
-
L
-
P
L
A
A
I
V
T
S
A
A
I
E
E
-
R
A
H
E
-
L
G
Y
L
--
F
Y
T
T
H
V
S
D
P
L
----
P
A
A
V
G
L
R
V
L
D
V
V
Q
R
D
G
L
V
A
R
A
N
V
M
G
D
R
L
R
R
G
L
L
D
L
M
E
-
R
F
D
C
I
G
D
V
R
G
R
G
L
L
L
G
V
E
I
----
V
----
K
--
D
RRTKEPADG
L
G
A
--
K
--
I
T
R
E
C
-
M
-------------------------
N
L
G
L
S
M
N
I
V
Q
L
P
G
M
G
G
-
V
F
R
I
A
P
P
L
T
V
S
E
D
E
-
I
D
L
G
L
S
L
L
-
G
Q
A
I
E
R
A
-------