@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1590: (2016-03-26 )
MELIKGNIASPKGFYADGKHAGLKRKRNDIGWIYSEVPANAAAVYTMNQMQAAPIFVTKDSFQSNAKLQAIIVNSGNANACTGNQGMLDALAMRAQTAEKLEIPLDSVAVASTGIIGDMLPMDKINAGIEMLEKQTGNAADFEEAILTTDTFQKQISFQTEIGGRKVTMSGVAKGSGMIHPNMATMLAFITTDAAIPAELLQKLLKIKVDKTFNQITVDGDTSTNDMVVVMANGCAENPMLQEGTADFAKFADMFQAVTEHLAKSIARDGEGATKLIEVQVNGATKTEDARMIAKKIVSSSLVKTAAFGGDGNWGRIICAIGYSGGRFAPDNITIKIGGIEILNHSSQTIYNQQALDAYLEEEHIIIEVDLHIGLESGTAWGCDLSYEYVKINACYRT
Atome Classification :
(20 SA)
.........10........20....-.-...30........40........50........60........70........80........90........100.......110.......120.......130...--..-..-140...---....150.......160.......170.......180.......190....-...200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320...--.--...330-........340.......350--.......----.360.-.......370.......380.......390......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELIKGNIASPKGFYADGKHAGLKR-K-RNDI
G
W
I
Y
SEVPAN
A
A
A
V
Y
T
MNQMQAA
P
I
F
V
TKDSFQSNA
K
L
Q
A
I
I
V
NSGNANACTGN
Q
G
M
L
D
A
L
A
M
R
A
QT
A
E
KLEIPL
D
S
V
A
V
ASTGIIGDML
P
M
D
K
I
N
A
G
I
E
M
L
E
K
Q--TG-
N
A
-
A
D
F
E
E
A
---
I
L
T
T
D
T
F
Q
K
Q
I
S
F
Q
TEIGG
R
K
V
T
M
S
GVAKGSGMIHP
N
M
A
T
M
L
A
F
ITTDAA
I
-
P
A
E
L
L
Q
K
L
L
K
I
K
VDKTF
N
Q
I
T
VDGDTSTN
D
M
V
V
V
MANGCAENP
M
L
QEG
T
A
D
F
A
K
F
A
D
M
F
Q
A
V
T
E
H
L
A
K
S
I
ARDGEG
A
T
K
L
I
E
V
Q
VNGATK
T
E
D
A
R
M
I
A
K
K
I
V
S
S
S
L
V
K
T
A
AFGGDGNW
G
R
I
I
C
A
I
GYSG--G--RFAPD--
N
I
T
I
K
IG
G
I
E
I
LNHSSQ
T
I
Y
---
N
Q
Q
A
L
D
A
----
Y
LE-E-E
H
I
I
I
E
V
D
L
H
I
G
LESGTAWGCD
L
S
Y
E
Y
V
K
I
N
A
C
YRT
19
PsiBlast_CBE
97.63
36%
-81
- C8 -
1VZ6
2
GNAT2_STRCL
B:
[8-390]
---------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
-
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
E
H
L
K
T
L
E
W
P
--
A
G
-
E
G
-
G
-
F
D
R
A
ARA
I
M
T
T
D
T
R
P
K
E
V
--
R
V
S
V
G
G
--
A
T
L
V
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
-
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
--
D
--
D
T
D
I
D
QE
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
----------
D
D
A
L
R
A
AVAE
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
40
HHSearch
97.31
35%
-78
- C8 -
1VZ6
2
GNAT2_STRCL
A:
[8-390]
---------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
A
D
-
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
E
H
L
K
T
L
E
W
P
--
A
G
E
G
G
F
D
R
A
A
R
A
---
I
M
T
T
D
T
R
P
K
E
V
R
V
S
V
G
----
G
A
T
L
V
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
-
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
G
E
V
-------
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
--
D
I
D
Q
E
--
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
------D
D
A
L
R
A
A
V
A
E
----
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
63
Fugue
97.25
35%
-78
- C8 -
1VZ6
2
GNAT2_STRCL
A:
[8-390]
---------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
D
G
-
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
A
D
G
-
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
E
H
L
K
T
L
E
W
P
AG
E
G
-
G
F
-
D
R
A
A
R
A
---
I
M
T
T
D
T
R
P
K
E
V
R
V
S
V
----
G
G
A
T
L
V
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
-
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
--
D
DT
D
I
D
Q
E
--
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
D
---
D
A
---
L
R
A
A
V
A
E
----
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
1
PsiBlast_PDB
97.22
36%
-81
- C8 -
1VZ6
2
GNAT2_STRCL
A:
[8-390]
---------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
-
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
E
H
L
K
T
L
E
W
P
--
A
G
-
E
G
-
G
-
F
D
R
A
A
R
A
I
M
T
T
D
T
R
P
K
E
V
--
R
V
S
V
G
G
--
A
T
L
V
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
-
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
--
D
--
D
T
D
I
D
QE
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
----------
D
D
A
L
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
18
PsiBlast_CBE
97.15
36%
-82
- C8 -
1VZ7
1
GNAT2_STRCL
B:
[8-390]
---------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
-
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
E
H
L
K
T
L
E
W
P
--
A
G
-
E
G
-
G
-
F
D
R
A
A
R
A
I
M
T
T
D
T
R
P
K
E
V
--
R
V
S
V
G
G
--
A
T
L
V
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
-
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
--
D
--
D
T
D
I
D
Q
E
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
----------
D
D
A
L
R
A
AVAE
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
2
PsiBlast_PDB
96.38
36%
-80
- C8 -
1VZ7
1
GNAT2_STRCL
A:
[8-390]
---------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
-
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
E
H
L
K
T
L
E
W
P
--
A
G
-
E
G
-
G
-
F
D
R
A
A
R
A
I
M
T
T
D
T
R
P
K
E
V
--
R
V
S
V
G
G
--
A
T
L
V
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
-
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
--
D
--
D
T
D
I
D
QE
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
----------
D
D
A
L
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
4
PsiBlast_PDB
95.32
35%
-82
- C8 -
1VZ8
3
GNAT2_STRCL
A:
[8-390]
---------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
-
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
E
H
L
K
T
L
E
W
P
--
A
G
-
E
G
-
G
-
F
D
R
A
A
R
A
I
M
T
T
D
T
R
P
K
E
V
--
R
V
S
V
G
G
--
A
T
L
V
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
-
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
--
D
--
D
T
D
I
D
QE
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
----------
D
D
A
L
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
16
PsiBlast_CBE
95.19
36%
-79
- C8 -
1VZ7
1
GNAT2_STRCL
D:
[8-390]
---------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
--
P
A
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
-
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
L
G
L
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
E
H
L
K
T
L
E
W
P
--
A
G
-
E
G
-
G
-
F
D
R
A
ARA
I
M
T
T
D
T
R
P
K
E
V
--
R
V
S
V
G
G
--
A
T
L
V
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
-
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
--
D
--
D
T
D
I
D
QE
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
----------
D
D
A
L
R
A
AVAE
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
17
PsiBlast_CBE
90.72
36%
-81
- C8 -
1VZ7
1
GNAT2_STRCL
C:
[8-390]
---------
T
P
R
G
F
V
V
H
T
A
P
V
G
L
A
D
-
D
G
R
D
D
F
T
V
L
A
S
T
A
--
T
V
S
A
V
F
T
R
S
R
F
A
G
P
S
V
V
L
C
R
E
A
V
-
A
D
G
Q
A
R
G
V
V
V
L
A
R
N
A
N
V
A
T
G
L
E
G
E
E
N
A
R
E
V
R
E
A
V
A
R
A
---
P
E
G
E
M
L
I
A
S
T
G
V
I
G
R
Q
Y
P
M
E
S
I
R
E
H
L
K
T
L
E
W
------------
D
R
A
ARA
I
M
T
T
D
T
R
P
K
E
V
--
R
V
-------
T
L
V
G
I
A
K
G
V
G
M
L
E
P
D
M
A
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
-
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
--
D
--
D
T
D
I
D
Q
E
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
----------
D
D
A
L
R
A
A
VAE
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
41
HHSearch
80.71
57%
-103
- C8 -
1VRA
7
?
B:
[1-213]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
S
F
V
T
T
D
A
N
I
-
D
H
G
H
L
Q
G
A
L
S
A
I
T
N
E
T
F
N
R
I
T
V
D
G
D
T
S
T
N
D
M
V
V
V
M
A
S
G
L
A
E
N
E
T
L
T
P
E
H
P
D
W
A
N
F
Y
K
A
L
Q
L
A
C
E
D
L
A
K
Q
I
A
R
D
G
E
G
A
T
K
L
I
E
V
E
V
T
G
A
A
N
D
Q
E
A
G
M
V
A
K
Q
I
V
G
S
D
L
V
K
T
A
I
Y
G
A
D
A
N
W
G
R
I
I
C
A
I
G
Y
S
G
--
C
--
E
V
N
Q
E
--
T
I
D
I
A
I
G
P
I
V
T
L
K
Q
S
E
P
T
G
F
---
S
E
E
E
A
T
A
----
Y
L
K
E
A
-
D
P
V
K
I
S
V
N
L
H
I
G
N
G
T
G
K
A
W
G
C
D
L
T
Y
D
Y
V
R
I
N
A
G
Y
--
3
PsiBlast_PDB
80.15
55%
-105
- C8 -
1VRA
7
?
B:
[1-213]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
S
F
V
T
T
D
A
N
I
-
D
H
G
H
L
Q
G
A
L
S
A
I
T
N
E
T
F
N
R
I
T
V
D
G
D
T
S
T
N
D
M
V
V
V
M
A
S
G
L
A
E
N
E
T
L
T
P
E
H
P
D
W
A
N
F
Y
K
A
L
Q
L
A
C
E
D
L
A
K
Q
I
A
R
D
G
E
G
A
T
K
L
I
E
V
E
V
T
G
A
A
N
D
Q
E
A
G
M
V
A
K
Q
I
V
G
S
D
L
V
K
T
A
I
Y
G
A
D
A
N
W
G
R
I
I
C
A
I
G
Y
S
G
--
C
--
E
V
N
Q
E
--
T
I
D
I
A
I
G
P
I
V
T
L
K
Q
S
E
P
T
G
F
---
S
E
E
E
A
T
A
----
Y
L
K
-
E
A
D
P
V
K
I
S
V
N
L
H
I
G
N
G
T
G
K
A
W
G
C
D
L
T
Y
D
Y
V
R
I
N
A
G
Y
--
5
PsiBlast_PDB
71.08
39%
-100
- C8 -
2VZK
-
?
B:
[1-213]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
-
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
--
D
--
D
T
D
I
D
QE
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
K
A
R
G
D
Q
---
A
D
D
A
L
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
Y
T
T
42
HHSearch
69.50
38%
-105
- C8 -
2V4I
-
?
B:
[182-383]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
T
F
F
A
T
D
A
R
L
-
D
P
A
E
Q
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
G
E
V
-------
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
DD
T
--
D
I
D
Q
E
--
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
------D
D
A
L
R
A
A
V
A
E
----
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
6
PsiBlast_PDB
69.09
39%
-100
- C8 -
2YEP
1
?
F:
[1-212]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
-
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
--
D
--
D
T
D
I
D
QE
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
----------------AE--
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
Y
T
-
29
PsiBlast_CBE
68.67
34%
-97
- C8 -
3IT6
2
?
B:
[1-205]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
C
V
L
T
T
D
A
A
A
-
E
P
A
A
L
E
R
A
L
R
R
A
A
A
A
T
F
D
R
L
D
I
D
G
S
C
S
T
N
D
T
V
L
L
L
S
S
G
A
S
E
I
P
P
A
Q
------
A
D
L
D
E
A
V
L
R
V
C
D
D
L
C
A
Q
L
Q
A
D
A
E
G
V
T
K
R
V
T
V
T
V
T
G
A
A
T
E
D
D
A
L
V
A
A
R
Q
I
A
R
D
S
L
V
K
T
A
L
F
G
S
D
P
N
W
G
R
V
L
A
A
V
G
M
A
P
--
I
--
T
L
D
P
D
--
R
I
S
V
S
F
N
G
A
A
V
C
V
H
G
---
V
G
---
A
P
G
A
R
E
V
----
D
L
S
-
D
-
A
D
I
D
I
T
V
D
L
G
V
G
D
G
Q
A
R
I
R
T
T
D
L
S
H
A
Y
V
E
E
N
S
A
Y
S
S
43
HHSearch
68.50
57%
-39
- C8 -
1VRA
17
ARGJ_BACHD
A:
[23-208]
L
K
L
E
T
G
S
V
T
S
A
K
G
F
S
A
V
G
I
H
T
G
V
K
R
-
K
-
R
K
D
L
G
A
I
V
C
E
V
P
A
S
S
A
A
V
Y
T
L
N
K
V
Q
A
A
P
L
K
V
T
Q
E
S
I
A
V
E
G
K
L
Q
A
M
I
V
N
S
G
I
A
N
A
C
T
G
K
R
G
L
D
D
A
Y
T
M
R
A
V
G
A
E
T
F
H
I
P
E
H
Y
V
A
V
T
S
T
G
V
I
G
E
F
L
P
M
D
V
I
T
N
G
I
R
Q
L
K
P
E
--
A
T
I
E
G
A
H
A
F
N
E
A
---
I
L
T
T
D
T
V
E
K
H
T
C
Y
Q
T
I
V
N
G
K
T
V
T
V
G
G
V
A
K
G
S
G
M
I
H
P
N
M
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
68.44
34%
-102
- C8 -
3IT6
1
?
D:
[1-205]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
C
V
L
T
T
D
A
A
A
-
E
P
A
A
L
E
R
A
L
R
R
A
A
A
A
T
F
D
R
L
D
I
D
G
S
C
S
T
N
D
T
V
L
L
L
S
S
G
A
S
E
I
P
P
A
Q
------
A
D
L
D
E
A
V
L
R
V
C
D
D
L
C
A
Q
L
Q
A
D
A
E
G
V
T
K
R
V
T
V
T
V
T
G
A
A
T
E
D
D
A
L
V
A
A
R
Q
I
A
R
D
S
L
V
K
T
A
L
F
G
S
D
P
N
W
G
R
V
L
A
A
V
G
M
A
P
--
I
--
T
L
D
P
D
--
R
I
S
V
S
F
N
G
A
A
V
C
V
H
G
---
V
G
---
A
P
G
A
R
E
V
----
D
L
S
-
D
-
A
D
I
D
I
T
V
D
L
G
V
G
D
G
Q
A
R
I
R
T
T
D
L
S
H
A
Y
V
E
E
N
S
A
Y
S
S
7
PsiBlast_PDB
68.42
39%
-100
- C8 -
2V4I
-
?
B:
[182-383]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
T
F
F
A
T
D
A
R
L
D
P
A
E
Q
-
D
R
L
F
R
R
V
M
D
R
T
F
N
A
V
S
I
D
T
D
T
S
T
S
D
T
A
V
L
F
A
N
G
L
A
-------
G
E
V
D
A
G
E
F
E
E
A
L
H
T
A
A
L
A
L
V
K
D
I
A
S
D
G
E
G
A
A
K
L
I
E
V
Q
V
T
G
A
R
D
D
A
Q
A
K
R
V
G
K
T
V
V
N
S
P
L
V
K
T
A
V
H
G
C
D
P
N
W
G
R
V
A
M
A
I
G
K
C
S
--
D
--
D
T
D
I
D
QE
R
V
T
I
R
F
G
E
V
E
V
Y
P
P
----------
D
D
A
L
R
A
A
V
A
E
H
L
R
-
G
-
D
E
V
V
I
G
I
D
L
A
I
A
D
G
A
F
T
V
Y
G
C
D
L
T
E
G
Y
V
R
L
N
S
E
---
31
PsiBlast_CBE
67.98
34%
-102
- C8 -
3IT4
3
?
B:
[1-202]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
C
V
L
T
T
D
A
A
A
-
E
P
A
A
L
E
R
A
L
R
R
A
A
A
A
T
F
D
R
L
D
I
D
G
S
C
S
T
N
D
T
V
L
L
L
S
S
G
A
S
E
I
P
P
A
Q
------
A
D
L
D
E
A
V
L
R
V
C
D
D
L
C
A
Q
L
Q
A
D
A
E
G
V
T
K
R
V
T
V
T
V
T
G
A
A
T
E
D
D
A
L
V
A
A
R
Q
I
A
R
D
S
L
V
K
T
A
L
F
G
S
D
P
N
W
G
R
V
L
A
A
V
G
M
A
P
--
I
--
T
L
D
P
D
--
R
I
S
V
S
F
N
G
A
A
V
C
V
H
G
---
V
G
---
A
P
G
A
R
E
V
----
D
L
S
-
D
-
A
D
I
D
I
T
V
D
L
G
V
G
D
G
Q
A
R
I
R
T
T
D
L
S
H
A
Y
V
E
E
N
S
A
---
30
PsiBlast_CBE
67.21
34%
-93
- C8 -
3IT4
2
?
D:
[1-202]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
C
V
L
T
T
D
A
A
A
-
E
P
A
A
L
E
R
A
L
R
R
A
A
A
A
T
F
D
R
L
D
I
D
G
S
C
S
T
N
D
T
V
L
L
L
S
S
G
A
S
E
I
P
P
A
Q
------
A
D
L
D
E
A
V
L
R
V
C
D
D
L
C
A
Q
L
Q
A
D
A
E
G
V
T
K
R
V
T
V
T
V
T
G
A
A
T
E
D
D
A
L
V
A
A
R
Q
I
A
R
D
S
L
V
K
T
A
L
F
G
S
D
P
N
W
G
R
V
L
A
A
V
G
M
A
P
--
I
--
T
L
D
P
D
--
R
I
S
V
S
F
N
G
A
A
V
C
V
H
G
---
V
G
---
A
P
----
V
----
D
L
S
-
D
-
A
D
I
D
I
T
V
D
L
G
V
G
D
G
Q
A
R
I
R
T
T
D
L
S
H
A
Y
V
E
E
N
S
A
---