@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1591: (2016-03-26 )
MKVSIIGATGYGGLELIRLLHQHSSVDIATLHSFSAQAETLATFYPHLKDLAVSPLEKINPTEIIEKSDTVFIATPSGIAKDIALPYVDAGLNVIDLSGDFRLKDRQLYEKWYGKSAAPTEYIGKAEYGLAEFREKKETTFIANPGCYATATLLGLAPLATNKLIDPTSIIVDAKSGISGAGKVPSASTHFTETNENMTLYKMNSHQHIPEIMQQLTKWDESIPAIQFSTSLIPITRGIFTTIYVKPKNPITQKELHKLYESTYDNAPFVRIQPENVYPTVKQVTASNYCDIGLAYNEKTNVITIVSVIDNLVKGAAGQAIQNLNIMANFAESDGLRFIPVYP
Atome Classification :
(20 SA)
.........10........20....-----....30..---..-...----.40........50------........60.-.-.--......70........80..--......90........100.......110.......120.......130-.---.--.--.-.-----------..140.........150.......160......-.-170........180.......190.......200..-.-....210.......220---------.......230.......240.......250.......260.....----------..270--....----.--..280-......--.290..-.....300.......310.......320.......330.......340.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
V
S
I
I
GATGY
G
G
L
E
L
I
R
L
L
H
Q
HSS-----V
D
I
A
T
L
HS---FS-
A
Q
A
----
E
T
L
A
T
F
Y
P
H
L
K
D
L
------AVSPLEKI
N
-
P
-
T
-
E
--IIEKS
D
T
V
F
I
ATPSG
I
A
K
DI--A
L
P
Y
V
DAG
L
N
V
I
DLSGD
F
R
L
K
D
R
Q
L
Y
E
K
W
YGKSAAP
T
E
Y
IG
K
A
EY
G
L
A
E
-
F
---
R
--E--K-K-----------E
T
T
--
F
IANPG
C
Y
A
T
A
T
L
LGLAPLATNKLIDP
T
-
S
-
I
-
I
V
DAKSGISGAGKVPSAST
H
F
TETNE
N
M
T
L
Y
KMN-S-H
Q
H
I
P
E
I
M
Q
Q
L
T
K
W
DES---------IP
A
I
Q
FSTS
L
I
P
ITRG
I
F
T
T
I
Y
V
KPKNPI
T
Q
K
E
L
H
K
L
Y
E
S
TYDNA----------
P
F
V
R
I--QPEN----V--Y
P
T
V
K
-
Q
VTASN--
Y
C
D
I
G
L
-
A
YNEKT
N
V
I
T
I
V
S
V
I
D
N
L
V
KGAAG
Q
A
I
Q
N
L
N
I
M
A
N
FAESDG
L
R
F
I
PVYP
21
PsiBlast_CBE
92.17
35%
-92
- C3 -
2I3G
2
ARGC_MYCTU
B:
[11-352]
-
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
GR
L
R
I
G
A
L
T
A
---
A
T
-
S
A
G
----
S
T
L
G
E
H
H
P
H
L
T
P
L
------
A
H
R
V
V
E
----
P
-
T
-
E
AA
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
--
A
Q
Q
L
S
P
E
T
L
-
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
S
-----
H
A
G
S
W
P
Y
G
L
P
E
-
L
PG
A
R
--
D
--
Q
L
R
-----------
G
T
R
--
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
D
L
I
E
P
--
A
-
V
-
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
-
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
---------
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
R
T
R
S
P
L
S
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
E
----------
P
F
I
Y
L
--
M
P
E
G
----
Q
--
L
P
R
T
G
-
A
V
I
G
S
N
--
A
A
H
I
A
V
-
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
7
PsiBlast_PDB
91.55
35%
-92
- C3 -
2I3G
2
ARGC_MYCTU
A:
[11-352]
-
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
GR
L
R
I
G
A
L
T
A
---
A
T
-
S
A
G
----
S
T
L
G
E
H
H
P
H
L
T
P
L
------
A
H
R
V
V
E
----
P
-
T
-
E
AA
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
--
A
Q
Q
L
S
P
E
T
L
-
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
S
-----
H
A
G
S
W
P
Y
G
L
P
E
-
L
PG
A
R
--
D
--
Q
L
R
-----------
G
T
R
--
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
D
L
I
E
P
--
A
-
V
-
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
-
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
---------
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
R
T
R
S
P
L
S
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
E
----------
P
F
I
Y
L
--
M
P
E
G
----
Q
--
L
P
R
T
G
-
A
V
I
G
S
N
--
A
A
H
I
A
V
-
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
23
PsiBlast_CBE
91.30
35%
-92
- C3 -
2I3A
1
ARGC_MYCTU
C:
[11-352]
-
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
GR
L
R
I
G
A
L
T
A
---
A
T
-
S
A
G
----
S
T
L
G
E
H
H
P
H
L
T
P
L
------
A
H
R
V
V
E
----
P
-
T
-
E
AA
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
--
A
Q
Q
L
S
P
E
T
L
-
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
S
-----
H
A
G
S
W
P
Y
G
L
P
E
-
L
PG
A
R
--
D
--
Q
L
R
-----------
G
T
R
--
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
D
L
I
E
P
--
A
-
V
-
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
-
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
---------
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
R
T
R
S
P
L
S
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
E
----------
P
F
I
Y
L
--
M
P
E
G
----
Q
--
L
P
R
T
G
-
A
V
I
G
S
N
--
A
A
H
I
A
V
-
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
24
PsiBlast_CBE
91.08
35%
-90
- C3 -
2I3A
1
ARGC_MYCTU
B:
[11-352]
-
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
GR
L
R
I
G
A
L
T
A
---
A
T
-
S
A
G
----
S
T
L
G
E
H
H
P
H
L
T
P
L
------
A
H
R
V
V
E
----
P
-
T
-
E
AA
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
--
A
Q
Q
L
S
P
E
T
L
-
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
S
-----
H
A
G
S
W
P
Y
G
L
P
E
-
L
PG
A
R
--
D
--
Q
L
R
-----------
G
T
R
--
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
D
L
I
E
P
--
A
-
V
-
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
-
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
---------
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
R
T
R
S
P
L
S
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
E
----------
P
F
I
Y
L
--
M
P
E
G
----
Q
--
L
P
R
T
G
-
A
V
I
G
S
N
--
A
A
H
I
A
V
-
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
10
PsiBlast_PDB
90.14
35%
-88
- C3 -
2NQT
-
ARGC_MYCTU
A:
[11-352]
-
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
GR
L
R
I
G
A
L
T
A
---
A
T
-
S
A
G
----
S
T
L
G
E
H
H
P
H
L
T
P
L
------
A
H
R
V
V
E
----
P
-
T
-
E
AA
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
--
A
Q
Q
L
S
P
E
T
L
-
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
S
-----
H
A
G
S
W
P
Y
G
L
P
E
-
L
PG
A
R
--
D
--
Q
L
R
-----------
G
T
R
--
R
I
A
V
P
G
-
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
D
L
I
E
P
--
A
-
V
-
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
-
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
---------
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
R
T
R
S
P
L
S
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
E
----------
P
F
I
Y
L
--
M
P
E
G
----
Q
--
L
P
R
T
G
-
A
V
I
G
S
N
--
A
A
H
I
A
V
-
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
22
PsiBlast_CBE
89.97
35%
-87
- C3 -
2I3A
1
ARGC_MYCTU
D:
[11-352]
-
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
YADGR
L
R
I
G
A
L
T
A
---
A
T
-
S
A
G
----
S
T
L
G
E
H
H
P
H
L
T
P
L
------
A
H
R
V
V
E
----
P
-
T
-
E
AA
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
--
A
Q
Q
L
S
P
E
T
L
-
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
S
-----
H
A
G
S
W
P
Y
G
L
P
E
-
L
PGA
R
--
D
--
Q
L
R
-----------
G
T
R
--
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
D
L
I
E
P
--
A
-
V
-
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
-
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
---------
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
R
T
R
S
P
L
S
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
E
----------
P
F
I
Y
L
--
M
P
E
G
----
Q
--
L
P
R
T
G
-
A
V
I
G
S
N
--
A
A
H
I
A
V
-
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
5
PsiBlast_PDB
89.69
35%
-98
- C3 -
2G17
10
ARGC_SALTY
A:
[9-336]
----
I
V
G
A
S
G
Y
A
G
A
E
L
V
S
Y
V
N
R
H
P
H
-----
M
T
I
T
A
L
-
T
---
V
S
-
A
Q
S
NDAG
K
L
I
S
D
L
H
P
Q
L
K
G
I
------
V
D
L
P
L
Q
P
M
S
-
D
-
V
R
D
--
F
S
A
D
V
D
V
V
F
L
A
T
A
H
E
V
S
H
D
L
--
A
P
Q
F
L
Q
A
G
C
V
V
F
D
L
S
G
A
F
R
V
N
D
R
A
F
Y
E
K
Y
Y
G
F
T
H
Q
Y
P
E
L
L
E
Q
A
V
Y
G
L
A
E
-
W
---
N
--
V
--
D
-
K
-----------
L
N
T
AN
L
I
A
V
P
G
C
Y
P
T
A
A
Q
L
S
L
K
P
L
I
D
G
G
L
L
D
L
T
-
Q
-
W
P
V
I
N
A
T
S
G
V
S
G
A
G
R
K
A
A
I
S
N
S
F
C
E
V
--
S
L
Q
P
Y
G
V
F
-
T
-
H
R
H
Q
P
E
I
A
V
H
L
G
A
---------------
E
V
I
F
T
P
H
L
G
N
F
P
R
G
I
L
E
T
I
T
C
R
L
K
A
G
V
T
H
A
Q
V
A
D
V
L
Q
K
A
Y
G
D
K
----------
P
L
V
R
L
--
Y
D
K
G
----
V
---
P
A
L
K
-
N
V
V
G
L
P
--
F
C
D
I
G
F
-
A
V
Q
G
E
H
--
L
I
V
V
A
T
E
D
N
L
L
K
G
A
A
A
Q
A
V
Q
C
A
N
I
R
F
G
F
A
E
T
Q
S
L
-------
32
HHSearch
89.67
35%
-80
- C3 -
2NQT
-
ARGC_MYCTU
A:
[10-352]
T
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
GR
L
R
I
G
A
L
T
A
---
A
T
-
S
A
G
----
S
T
L
G
E
H
H
P
H
L
T
P
L
-------
A
H
R
V
V
E
P
T
-
E
-
A
-
A
--
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
--
A
Q
Q
L
S
-
P
E
T
L
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
S
H
A
-----
G
S
W
P
Y
G
L
P
E
-
L
---
P
G
A
R
D
Q
L
-
R
-----------
G
T
R
--
R
I
A
V
P
G
-
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
D
L
I
--
E
P
A
-
V
-
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
G
V
-
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
---------
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
R
T
R
S
P
--
L
S
Q
L
R
A
A
Y
E
K
A
Y
H
A
E
----------
P
F
I
Y
L
--
M
P
E
G
----
Q
--
L
P
R
T
G
-
A
V
I
G
S
N
--
A
A
H
I
A
V
-
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
3
PsiBlast_PDB
89.53
35%
-96
- C3 -
2Q49
-
ARGC_ARATH
A:
[17-359]
I
R
I
G
L
L
G
A
S
G
Y
T
G
A
E
I
V
R
L
L
A
N
H
P
H
-----
F
Q
V
T
L
M
T
A
---
D
R
-
K
A
G
----
Q
S
M
E
S
V
F
P
H
L
R
A
Q
------
K
L
P
T
L
V
S
V
K
-
D
-
A
-
D
--
F
-
S
T
V
D
A
V
F
C
C
L
P
H
G
T
T
Q
E
I
---
I
K
E
L
P
T
A
L
K
I
V
D
L
S
A
D
F
R
L
R
N
I
A
E
Y
E
E
W
Y
G
Q
P
H
K
A
V
E
L
Q
K
E
V
V
Y
G
L
T
E
I
L
---
R
--
E
--
D
I
K
-----------
K
A
R
--
L
V
A
N
P
G
C
Y
P
T
T
I
Q
L
P
L
V
P
L
L
K
A
N
L
I
K
H
E
-
N
-
I
-
I
I
D
A
K
S
G
V
S
G
A
G
R
G
A
K
E
A
N
L
Y
S
E
I
A
E
G
I
S
S
Y
G
V
T
-
R
-
H
R
H
V
P
E
I
E
Q
G
L
S
D
V
A
Q
S
---------
K
V
T
V
S
F
T
P
H
L
M
P
M
I
R
G
M
Q
S
T
I
Y
V
E
M
A
P
G
V
R
T
E
D
L
H
Q
Q
L
K
T
S
Y
E
D
E
----------
E
F
V
K
V
--
L
D
E
G
----
V
--
V
P
R
T
H
-
N
V
R
G
S
N
--
Y
C
H
M
S
V
-
F
P
D
R
I
P
G
R
A
I
I
I
S
V
I
D
N
L
V
K
G
A
S
G
Q
A
L
Q
N
L
N
I
M
L
G
Y
P
E
T
T
G
L
L
H
Q
P
L
F
P
6
PsiBlast_PDB
88.81
35%
-88
- C3 -
2I3A
1
ARGC_MYCTU
A:
[11-352]
-
K
V
A
V
A
G
A
S
G
Y
A
G
G
E
I
L
R
L
L
L
G
H
P
A
Y
A
D
GR
L
R
I
G
A
L
T
A
---
A
T
-
S
A
G
----
S
T
L
G
E
H
H
P
H
L
T
P
L
------
A
H
R
V
V
E
----
P
-
T
-
E
AA
V
L
G
G
H
D
A
V
F
L
A
L
P
H
G
H
S
A
V
L
--
A
Q
Q
L
S
P
E
T
L
-
I
I
D
C
G
A
D
F
R
L
T
D
A
A
V
W
E
R
F
Y
G
S
S
-----
H
A
G
S
W
P
Y
G
L
P
E
-
L
PG
A
R
--
D
--
Q
L
R
-----------
G
T
R
--
R
I
A
V
P
G
C
Y
P
T
A
A
L
L
A
L
F
P
A
L
A
A
D
L
I
E
P
--
A
-
V
-
T
V
V
A
V
S
G
T
S
G
A
G
R
A
A
T
T
D
L
L
G
A
E
V
I
G
S
A
R
A
Y
N
I
A
-
G
V
H
R
H
T
P
E
I
A
Q
G
L
R
A
V
T
D
R
---------
D
V
S
V
S
F
T
P
V
L
I
P
A
S
R
G
I
L
A
T
C
T
A
R
T
R
S
P
L
S
Q
--
L
R
A
A
Y
E
K
A
Y
H
A
E
----------
P
F
I
Y
L
--
M
P
E
G
----
Q
--
L
P
R
T
G
-
A
V
I
G
S
N
--
A
A
H
I
A
V
-
A
V
D
E
D
A
Q
T
F
V
A
I
A
A
I
D
N
L
V
K
G
T
A
G
A
A
V
Q
S
M
N
L
A
L
G
W
P
E
T
D
G
L
S
V
V
G
V
A
P
2
PsiBlast_PDB
88.60
35%
-96
- C3 -
1XYG
-
ARGC_ARATH
A:
[17-359]
I
R
I
G
L
L
G
A
S
G
Y
T
G
A
E
I
V
R
L
L
A
N
H
P
H
-----
F
Q
V
T
L
M
T
A
---
D
R
-
K
A
G
----
Q
S
M
E
S
V
F
P
H
L
R
A
Q
------
K
L
P
T
L
V
S
V
K
-
D
-
A
-
D
--
F
-
S
T
V
D
A
V
F
C
C
L
P
H
G
T
T
Q
E
I
---
I
K
E
L
P
T
A
L
K
I
V
D
L
S
A
D
F
R
L
R
N
I
A
E
Y
E
E
W
Y
G
Q
P
H
K
A
V
E
L
Q
K
E
V
V
Y
G
L
T
E
I
L
---
R
--
E
--
D
I
K
-----------
K
A
R
--
L
V
A
N
P
G
C
Y
P
T
T
I
Q
L
P
L
V
P
L
L
K
A
N
L
I
K
H
E
-
N
-
I
-
I
I
D
A
K
S
G
V
S
G
A
G
R
G
A
K
E
A
N
L
Y
S
E
I
A
E
G
I
S
S
Y
G
V
T
-
R
-
H
R
H
V
P
E
I
E
Q
G
L
S
D
V
A
Q
S
---------
K
V
T
V
S
F
T
P
H
L
M
P
M
I
R
G
M
Q
S
T
I
Y
V
E
M
A
P
G
V
R
T
E
D
L
H
Q
Q
L
K
T
S
Y
E
D
E
----------
E
F
V
K
V
--
L
D
E
G
----
V
--
V
P
R
T
H
-
N
V
R
G
S
N
--
Y
C
H
M
S
V
-
F
P
D
R
I
P
G
R
A
I
I
I
S
V
I
D
N
L
V
K
G
A
S
G
Q
A
L
Q
N
L
N
I
M
L
G
Y
P
E
T
T
G
L
L
H
Q
P
L
F
P
34
HHSearch
87.82
36%
-98
- C3 -
3DR3
3
ARGC_SHIFL
A:
[5-337]
L
N
T
L
I
V
G
A
S
G
Y
A
G
A
E
L
V
T
Y
V
N
R
H
P
H
-----
M
N
I
T
A
L
T
V
S
AQ
S
N
-
D
A
G
----
K
L
I
S
D
L
H
P
Q
L
K
G
I
------
V
E
L
P
L
Q
P
M
S
D
I
-
S
-
E
--
F
S
P
G
V
D
V
V
F
L
A
T
A
H
E
V
S
H
D
L
--
A
P
Q
F
L
E
A
G
C
V
V
F
D
L
S
G
A
F
R
V
N
D
A
T
F
Y
E
K
Y
Y
G
F
T
H
Q
Y
P
E
L
L
E
Q
A
A
Y
G
L
A
E
-
W
---
C
--
G
NK
L
-
K
-----------
E
A
N
--
L
I
A
V
P
G
C
Y
P
T
A
A
Q
L
A
L
K
P
L
I
D
A
D
L
L
D
L
N
-
Q
W
P
-
V
I
N
A
T
S
G
V
S
G
A
G
R
K
A
A
I
S
N
S
F
C
E
--
V
S
L
Q
P
Y
G
V
F
-
T
-
H
R
H
Q
P
E
I
A
T
H
L
G
A
---------------
D
V
I
F
T
P
H
L
G
N
F
P
R
G
I
L
E
T
I
T
C
R
L
K
S
G
V
T
Q
A
Q
V
A
Q
A
L
Q
Q
A
Y
A
H
K
----------
P
L
V
R
L
--
Y
D
K
-----
G
--
V
P
A
L
K
-
N
V
V
G
L
P
--
F
C
D
I
G
F
A
V
Q
---
G
E
H
L
I
I
V
A
T
E
D
N
L
L
K
G
A
A
A
Q
A
V
Q
C
A
N
I
R
F
G
Y
A
E
T
Q
S
L
I
------
8
PsiBlast_PDB
87.68
35%
-98
- C3 -
3DR3
3
ARGC_SHIFL
A:
[9-336]
----
I
V
G
A
S
G
Y
A
G
A
E
L
V
T
Y
V
N
R
H
P
H
-----
M
N
I
T
A
L
-
T
---
V
S
-
A
Q
S
NDAG
K
L
I
S
D
L
H
P
Q
L
K
G
I
------
V
E
L
P
L
Q
P
M
S
-
D
I
S
-
E
--
F
S
P
G
V
D
V
V
F
L
A
T
A
H
E
V
S
H
D
L
--
A
P
Q
F
L
E
A
G
C
V
V
F
D
L
S
G
A
F
R
V
N
D
A
T
F
Y
E
K
Y
Y
G
F
T
H
Q
Y
P
E
L
L
E
Q
A
A
Y
G
L
A
E
-
W
CG-
N
--
K
--
L
-
K
-----------
E
A
N
--
L
I
A
V
P
G
C
Y
P
T
A
A
Q
L
A
L
K
P
L
I
D
A
D
L
L
D
L
N
-
Q
-
W
P
V
I
N
A
T
S
G
V
S
G
A
G
R
K
A
A
I
S
N
S
F
C
E
V
--
S
L
Q
P
Y
G
V
F
-
T
-
H
R
H
Q
P
E
I
A
T
H
L
G
A
---------------
D
V
I
F
T
P
H
L
G
N
F
P
R
G
I
L
E
T
I
T
C
R
L
K
S
G
V
T
Q
A
Q
V
A
Q
A
L
Q
Q
A
Y
A
H
K
----------
P
L
V
R
L
--
Y
D
K
G
----
V
---
P
A
L
K
-
N
V
V
G
L
P
--
F
C
D
I
G
F
-
A
V
Q
G
E
H
--
L
I
I
V
A
T
E
D
N
L
L
K
G
A
A
A
Q
A
V
Q
C
A
N
I
R
F
G
Y
A
E
T
Q
S
L
-------
9
PsiBlast_PDB
87.35
32%
-93
- C3 -
2OZP
9
?
A:
[7-345]
--
L
S
I
V
G
A
S
G
Y
A
G
G
E
F
L
R
L
A
L
S
H
P
Y
-----
L
E
V
K
Q
V
T
S
---
R
R
-
F
A
G
----
E
P
V
H
F
V
H
P
N
L
R
G
R
------
T
N
L
---
K
F
V
-
P
-
P
-
E
--
K
L
E
P
A
D
I
L
V
L
A
L
P
H
G
V
F
A
R
E
--
F
D
R
Y
S
A
L
A
P
V
L
V
D
L
S
A
D
F
R
L
K
D
P
E
L
Y
R
R
Y
Y
G
E
H
P
R
P
-
D
L
L
G
R
F
V
Y
A
V
P
E
L
Y
---
R
--
E
--
A
L
K
-----------
G
A
D
--
W
I
A
G
A
G
C
N
A
T
A
T
L
L
G
L
Y
P
L
L
K
A
G
V
L
K
P
T
-
P
-
I
-
F
V
T
L
L
I
S
T
S
A
G
G
A
E
A
S
P
A
S
H
H
P
E
R
A
G
S
I
R
V
Y
K
P
T
-
G
-
H
R
H
T
A
E
V
V
E
N
L
P
----
G
---------
R
P
E
V
H
L
T
A
I
A
T
D
R
V
R
G
I
L
M
T
A
Q
C
F
V
Q
D
G
W
S
E
R
D
V
W
Q
A
Y
R
E
A
Y
A
G
E
----------
P
F
I
R
L
VK
Q
K
K
G
----
V
HR
Y
P
D
P
R
-
F
V
Q
G
T
N
--
Y
A
D
I
G
F
-
E
L
E
E
D
T
G
R
L
V
V
M
T
A
I
D
N
L
V
K
G
T
A
G
H
A
L
Q
A
L
N
V
R
M
G
W
P
E
T
L
G
L
D
F
P
G
L
H
P
31
HHSearch
87.25
35%
-93
- C3 -
1XYG
-
ARGC_ARATH
A:
[17-359]
I
R
I
G
L
L
G
A
S
G
Y
T
G
A
E
I
V
R
L
L
A
N
H
P
H
-----
F
Q
V
T
L
M
T
A
---
D
R
-
K
A
G
----
Q
S
M
E
S
V
F
P
H
L
R
A
Q
------
K
L
P
T
L
V
S
V
K
---
D
-
A
--
D
F
S
T
V
D
A
V
F
C
C
L
P
H
G
T
T
Q
E
I
--
I
K
E
L
P
-
T
A
L
K
I
V
D
L
S
A
D
F
R
L
R
N
I
A
E
Y
E
E
W
Y
G
Q
P
H
K
A
V
E
L
Q
K
E
V
V
Y
G
L
T
E
-
I
---
L
--
R
E
D
I
-
K
-----------
K
A
R
--
L
V
A
N
P
G
C
Y
P
T
T
I
Q
L
P
L
V
P
L
L
K
A
N
L
I
K
H
E
-
N
-
I
-
I
I
D
A
K
S
G
V
S
G
A
G
R
G
A
K
E
A
N
L
Y
S
E
I
A
E
G
I
S
S
Y
G
V
T
-
R
-
H
R
H
V
P
E
I
E
Q
G
L
S
D
V
A
Q
S
---------
K
V
T
V
S
F
T
P
H
L
M
P
M
I
R
G
M
Q
S
T
I
Y
V
E
M
A
P
G
V
R
T
E
D
L
H
Q
Q
L
K
T
S
Y
E
D
E
----------
E
F
V
K
V
--
L
D
E
G
----
V
--
V
P
R
T
H
-
N
V
R
G
S
N
--
Y
C
H
M
S
V
-
F
P
D
R
I
P
G
R
A
I
I
I
S
V
I
D
N
L
V
K
G
A
S
G
Q
A
L
Q
N
L
N
I
M
L
G
Y
P
E
T
T
G
L
L
H
Q
P
L
F
P
33
HHSearch
87.01
32%
-88
- C3 -
2OZP
9
?
A:
[5-345]
K
T
L
S
I
V
G
A
S
G
Y
A
G
G
E
F
L
R
L
A
L
S
H
P
Y
-----
L
E
V
K
Q
V
T
S
---
R
R
-
F
A
G
----
E
P
V
H
F
V
H
P
N
L
R
G
R
------
T
N
L
K
F
V
P
P
------
E
--
K
L
E
P
A
D
I
L
V
L
A
L
P
H
G
V
F
A
R
E
--
F
D
R
Y
S
A
L
A
P
V
L
V
D
L
S
A
D
F
R
L
K
D
P
E
L
Y
R
R
Y
Y
G
E
-
H
P
R
P
D
L
L
G
R
F
V
Y
A
V
P
E
-
L
---
Y
--
R
E
A
L
-
K
-----------
G
A
D
--
W
I
A
G
A
G
C
N
A
T
A
T
L
L
G
L
Y
P
L
L
K
A
G
V
L
K
P
T
-
P
-
I
-
F
V
T
L
L
I
S
T
S
A
G
G
A
E
A
S
P
A
S
H
H
P
E
R
A
G
S
I
R
V
Y
K
P
T
-
G
-
H
R
H
T
A
E
V
V
E
N
L
P
G
-------------
R
P
E
V
H
L
T
A
I
A
T
D
R
V
R
G
I
L
M
T
A
Q
C
F
V
Q
D
G
W
S
E
R
D
V
W
Q
A
Y
R
E
A
Y
A
G
E
----------
P
F
I
R
L
--
V
K
Q
K
KGVH
R
--
Y
P
D
P
R
-
F
V
Q
G
T
N
--
Y
A
D
I
G
F
-
E
L
E
E
D
T
G
R
L
V
V
M
T
A
I
D
N
L
V
K
G
T
A
G
H
A
L
Q
A
L
N
V
R
M
G
W
P
E
T
L
G
L
D
F
P
G
L
H
P
30
HHSearch
79.37
42%
-52
- C3 -
1VKN
-
ARGC_THEMA
A:
[2-339]
I
R
A
G
I
I
G
A
T
G
Y
T
G
L
E
L
V
R
L
L
K
N
H
P
E
-----
A
K
I
T
Y
L
S
S
---
R
T
-
Y
A
G
----
K
K
L
E
E
I
F
P
S
T
L
E
--------
N
S
I
L
S
E
F
D
-
P
-
E
-
K
--
V
S
K
N
C
D
V
L
F
T
A
L
P
A
G
A
S
Y
D
L
--
V
R
E
L
--
K
G
V
K
I
I
D
L
G
A
D
F
R
F
D
D
P
G
V
Y
R
E
W
Y
G
K
E
L
S
G
Y
E
N
I
-
K
R
V
Y
G
L
P
E
-
L
---
H
--
R
E
E
I
-
K
-----------
N
A
Q
--
V
V
G
N
P
G
C
Y
P
T
S
V
I
L
A
L
A
P
A
L
K
H
N
L
V
D
P
E
-
T
-
I
-
L
V
D
A
K
S
G
V
S
G
A
G
R
K
E
K
V
D
Y
L
F
S
E
V
N
E
S
L
R
P
Y
N
V
A
-
K
-
H
R
H
V
P
E
M
E
Q
E
L
G
K
I
S
G
K
---------
K
V
N
V
V
F
T
P
H
L
V
P
M
T
R
G
I
L
S
T
I
Y
V
K
T
D
K
--
S
L
E
E
I
H
E
A
Y
L
E
F
Y
K
N
E
----------
P
F
V
H
V
--
L
P
M
G
----
I
--
Y
P
S
T
K
-
W
C
Y
G
S
N
--
H
V
F
I
G
M
Q
M
E
E
R
-
T
N
T
L
I
L
M
S
A
I
D
N
L
V
K
G
A
S
G
Q
A
V
Q
N
M
N
I
M
F
G
L
D
E
T
K
G
L
E
F
T
P
I
Y
P
1
PsiBlast_PDB
77.75
41%
-53
- C3 -
1VKN
-
ARGC_THEMA
A:
[2-339]
I
R
A
G
I
I
G
A
T
G
Y
T
G
L
E
L
V
R
L
L
K
N
H
P
E
-----
A
K
I
T
Y
L
S
S
---
R
T
-
Y
A
G
----
K
K
L
E
E
I
F
P
--
S
T
L
------
E
N
S
I
L
S
E
F
D
-
P
-
E
-
K
--
V
S
K
N
C
D
V
L
F
T
A
L
P
A
G
A
S
Y
D
L
--
V
R
E
L
--
K
G
V
K
I
I
D
L
G
A
D
F
R
F
D
D
P
G
V
Y
R
E
W
Y
G
K
E
L
S
G
Y
E
N
I
-
K
R
V
Y
G
L
P
E
-
L
H
R
-
E
--
E
--
I
-
K
-----------
N
A
Q
--
V
V
G
N
P
G
C
Y
P
T
S
V
I
L
A
L
A
P
A
L
K
H
N
L
V
D
P
E
-
T
-
I
-
L
V
D
A
K
S
G
V
S
G
A
G
R
K
E
K
V
D
Y
L
F
S
E
V
N
E
S
L
R
P
Y
N
V
A
-
K
-
H
R
H
V
P
E
M
E
Q
E
L
G
K
I
S
G
K
---------
K
V
N
V
V
F
T
P
H
L
V
P
M
T
R
G
I
L
S
T
I
Y
V
K
T
D
K
S
L
--
E
E
I
H
E
A
Y
L
E
F
Y
K
N
E
----------
P
F
V
H
V
--
L
P
M
G
----
I
--
Y
P
S
T
K
-
W
C
Y
G
S
N
--
H
V
F
I
G
M
-
Q
M
E
E
R
T
N
T
L
I
L
M
S
A
I
D
N
L
V
K
G
A
S
G
Q
A
V
Q
N
M
N
I
M
F
G
L
D
E
T
K
G
L
E
F
T
P
I
Y
P
4
PsiBlast_PDB
73.27
36%
-42
- C3 -
2CVO
-
ARGC_ORYSJ
A:
[73-415]
V
R
I
A
V
L
G
A
S
G
Y
T
G
A
E
I
V
R
L
L
A
N
H
P
Q
-----
F
R
I
K
V
M
T
A
---
D
R
-
K
A
G
----
E
Q
F
G
S
V
F
P
H
L
I
T
Q
------
D
L
P
N
L
V
A
V
K
-
D
-
A
-
D
--
F
-
S
N
V
D
A
V
F
C
C
L
P
H
G
T
T
Q
E
I
I
K
G
L
P
---
Q
E
L
K
I
V
D
L
S
A
D
F
R
L
R
D
I
N
E
Y
A
E
W
Y
G
H
S
H
R
A
P
E
L
Q
Q
E
A
V
Y
G
L
T
E
-
V
L
R
-
N
--
E
--
I
-
R
-----------
N
A
R
--
L
V
A
N
P
G
C
Y
P
T
S
I
Q
L
P
L
V
P
L
I
K
A
K
L
I
K
V
S
-
N
-
I
-
I
I
D
A
K
S
G
V
S
G
A
G
R
G
A
K
E
A
N
L
Y
T
E
I
A
E
G
I
H
A
Y
G
I
K
-
G
-
H
R
H
V
P
E
I
E
Q
G
L
S
E
A
A
E
S
---------
K
V
T
I
S
F
T
P
N
L
I
C
M
K
R
G
M
Q
S
T
M
F
V
E
M
A
P
G
V
T
A
N
D
L
Y
Q
H
L
K
S
T
Y
E
G
E
----------
E
F
V
K
L
--
L
N
G
S
----
S
--
V
P
H
T
R
-
H
V
V
G
S
N
--
Y
C
F
M
N
V
-
F
E
D
R
I
P
G
R
A
I
I
I
S
V
I
D
N
L
V
K
G
A
S
G
Q
A
V
Q
N
L
N
L
M
M
G
L
P
E
N
T
G
L
Q
Y
Q
P
L
F
P
43
HHSearch
70.88
23%
-82
- C3 -
2EP5
-
?
A:
[5-347]
I
K
V
S
L
L
G
S
T
G
M
V
G
Q
K
M
V
K
M
L
A
K
H
P
Y
-----
L
E
L
V
K
V
S
A
---
S
P
S
K
I
G
----
K
K
Y
K
D
A
V
K
W
I
E
Q
G
DIPEEV
Q
D
L
P
I
V
S
T
N
---
Y
-
E
--
D
H
K
D
V
D
V
V
L
S
A
L
P
N
E
L
A
E
S
I
--
E
L
E
L
V
K
N
G
K
I
V
V
S
N
A
S
P
F
R
M
D
P
D
-------------------
V
P
L
I
N
P
E
-
I
---
N
--
W
EH
L
-
E
LLKF
Q
K
E
R
K
GW
K
G
I
--
L
V
K
N
P
N
C
T
A
A
I
M
S
M
P
I
K
P
L
I
E
I
A
T
K
--
S
-
K
-
I
-
I
I
T
T
L
Q
A
V
S
G
A
G
Y
N
G
I
---
S
F
M
A
I
E
G
N
I
I
P
Y
I
K
G
-----
E
E
D
K
I
A
K
E
L
T
K
L
N
G
K
L
E
NNQIIPA
N
L
D
S
T
V
T
S
I
R
V
P
T
R
V
G
H
M
G
V
I
N
I
V
T
N
E
R
I
N
I
E
E
I
K
K
T
L
K
N
F
K
S
L
P
Q
Q
K
NLPTAPK
Q
P
I
I
V
--
R
D
E
E
----
D
--
R
P
Q
P
I
I
D
V
N
A
E
S
GM
A
V
T
V
G
R
I
R
H
E
--
N
N
V
L
R
L
V
V
L
G
D
N
L
V
R
G
A
A
G
I
T
I
L
T
V
E
V
M
K
E
L
-------------