@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1598: (2016-03-26 )
MNIIDELEWRGAIYQQTDEEGLRKWVEEKQISLYCGIDPSGDSMHIGHLIPFMILRRFQNAGHRPIILVGGATGTIGDPSGKKEERKLQSMEQISKNVESLRVQLGKIFDFEGNSAASMVNNYDWTKDVSILDFLRDYGKEFNVNTMLSKDIVASRLEVGISFTEFAYQILQAMDFNHLYEFNDCRLQIGGSDQWGNITAGLDLIRKKQGENAKAFGLTIPLLTKADGTKFGKSEGGAIWLNPEKTTPYEFYQFWINTDDRDVVKYLKYFTFLTEAEIDELAKQVETEPHLRAAQKTLAAEMTKFVHSEEALEQALKISKALFSGDVKALTADEIEQGFKDVPTFVAEDSEANLVDWLVTLGIEPSKRQAREDVGNGAIYINGERQQDLEKIMDASDRIENKFTIVRRGKKKYFLVSYK
Atome Classification :
(30 SA)
.........10........20...----....----.30........40........50........60........70........80........90........100...-------....110--------.-.-.-----------.----------.--..--.--.120........130.......140.......150.....---.---.--160.........170.......180.......190.......200.......210--.------------.---------------......220.......230...-.-...240.......250.......----260.......270.......280.......290.......300.......310.......320..-...-..330.......340..-....---.350.......360.......370.......380.......390.......400.......410.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
I
I
D
E
L
E
WRG
A
I
YQQT
D
E
E
G
L
R
K
----
W
V
E
E----K
Q
I
S
L
Y
CGIDPSGDSM
H
I
G
H
L
I
P
F
M
I
L
R
R
F
QNAGHR
P
I
I
L
VGGATGTIGDPSG
K
K
E
E
R
K
L
Q
S
M
E
Q
I
S
K
N
V
E
S
L
R
V
Q
L-------
G
K
I
FD----------F-E-G-----------N----------
S
--
A
A
--
S
--
M
V-NNYDWTKD
V
S
I
L
D
F
L
R
D
Y
G
K
EFN
V
N
T
M
L
S
K
D
I
V
A
S
R
L
---
E
---V--G--I
S
F
T
E
F
A
Y
Q
I
L
Q
A
MDFNHLYEFND
C
R
L
Q
IGGSDQWG
N
I
T
A
G
L
D
L
I
R
K
KQGE---N------------A---------------
K
A
F
G
L
T
I
P
L
L
TKADGTKFGKSE-G-
G
A
I
W
LNPEKTT
P
Y
E
F
Y
Q
F
W
INTD----
D
R
D
V
V
K
Y
L
K
Y
F
T
F
L
T
E
A
E
I
D
E
L
A
K
Q
VETEP
H
L
R
A
A
Q
K
T
L
A
A
E
M
T
K
F
V
H
S
E
E
A
L
E
Q
A
L
K
I
S
K
A
L
FS-GDV-KAL
T
A
D
E
I
E
Q
G
F
K
DV
P
T
-
F
VAE---DSE
A
N
L
V
D
W
L
V
TLGIEP
S
K
R
Q
A
R
E
DVGN
G
A
I
Y
ING
E
R
Q
Q
D
L
E
K
I
M
D
A
S
D
R
IEN
K
F
T
I
V
RRGK
K
K
Y
F
L
V
SYK
96
HHSearch
94.52
43%
-95
- C4 -
2JAN
-
SYY_MYCTU
A:
[5-422]
--
I
L
D
E
L
S
W
R
G
L
I
A
Q
S
T
D
L
D
T
L
A
A
----
E
A
Q
R
----
G
P
M
T
V
Y
A
G
F
D
P
T
A
P
S
L
H
A
G
H
L
V
P
L
L
T
L
R
R
F
Q
R
A
G
H
R
P
I
V
L
A
G
G
A
T
G
M
I
G
D
P
R
D
-
V
G
E
R
S
L
N
E
A
D
T
V
A
E
W
T
E
R
I
R
G
Q
L
-------
E
R
F
V
D
----------
F
-
D
-
D
S----------
P
----------
M
--
G
A
--
I
--
V
E
-
N
N
L
E
W
T
G
S
L
S
A
I
E
F
L
R
D
I
G
K
H
F
S
V
N
V
M
L
A
R
D
T
I
R
R
R
L
---
A
G--
E
--
G
--
I
S
Y
T
E
F
S
Y
L
L
L
Q
A
N
D
Y
V
E
L
H
R
R
H
G
C
T
L
Q
I
G
G
A
D
Q
W
G
N
I
I
A
G
V
R
L
V
R
Q
K
L
G
-----------------
A
---------------
T
V
H
A
L
T
V
P
L
V
T
A
A
D
G
T
K
F
G
K
S
T
-
G
G
G
S
L
W
L
D
P
Q
M
T
S
P
Y
A
W
Y
Q
Y
F
V
N
T
A
----
D
A
D
V
I
R
Y
L
R
W
F
T
F
L
S
A
D
E
L
A
E
L
E
Q
A
T
A
Q
R
P
Q
Q
R
A
A
Q
R
R
L
A
S
E
L
T
V
L
V
H
G
E
A
A
T
A
A
V
E
H
A
S
R
A
L
F
G
-
R
G
E
L
A
R
L
D
E
A
T
L
A
A
A
L
R
E
T
T
V
A
E
L
K
P
---
G
S
P
D
G
I
V
D
L
L
V
A
S
G
L
S
A
S
K
G
A
A
R
R
T
I
H
E
G
G
V
S
V
N
N
I
R
V
D
N
E
E
W
V
P
Q
S
S
D
F
L
H
G
R
W
L
V
L
R
R
G
K
R
S
I
A
G
V
E
R
-
12
PsiBlast_PDB
92.96
44%
-88
- C4 -
2JAN
-
SYY_MYCTU
A:
[5-416]
--
I
L
D
E
L
S
W
R
G
L
I
A
Q
S
T
D
L
D
T
L
A
A
----
E
A
Q
R
----
G
P
M
T
V
Y
A
G
F
D
P
T
A
P
S
L
H
A
G
H
L
V
P
L
L
T
L
R
R
F
Q
R
A
G
H
R
P
I
V
L
A
G
G
A
T
G
M
I
G
D
P
R
-
D
V
G
E
R
S
L
N
E
A
D
T
V
A
E
W
T
E
R
I
R
G
Q
L
-------
E
R
F
V
D
----------
F
-
D
-
D
-----------
S
----------
P
--
M
G
--
A
--
I
V
E
N
N
L
E
W
T
G
S
L
S
A
I
E
F
L
R
D
I
G
K
H
F
S
V
N
V
M
L
A
R
D
T
I
R
R
R
L
---
A
---
G
E-
G
--
I
S
Y
T
E
F
S
Y
L
L
L
Q
A
N
D
Y
V
E
L
H
R
R
H
G
C
T
L
Q
I
G
G
A
D
Q
W
G
N
I
I
A
G
V
R
L
V
R
Q
K
L
G
A
---
T
------------
V
---------------
H
A
--
L
T
V
P
L
V
T
A
A
D
G
T
K
F
G
K
S
T
G
G
-
G
S
L
W
L
D
P
Q
M
T
S
P
Y
A
W
Y
Q
Y
F
V
N
T
A
----
D
A
D
V
I
R
Y
L
R
W
F
T
F
L
S
A
D
E
L
A
E
L
E
Q
A
T
A
Q
R
P
Q
Q
R
A
A
Q
R
R
L
A
S
E
L
T
V
L
V
H
G
E
A
A
T
A
A
V
E
H
A
S
R
A
L
F
G
R
G
E
L
-
A
R
L
D
E
A
T
L
A
A
A
L
R
E
--
T
-
T
V
A
E
L
K
P
G
S
P
D
G
I
V
D
L
L
V
A
S
G
L
S
A
S
K
G
A
A
R
R
T
I
H
E
G
G
V
S
V
N
N
I
R
V
D
N
E
E
W
V
P
Q
S
S
D
F
L
H
G
R
W
L
V
L
R
R
G
K
R
S
-------
10
PsiBlast_PDB
89.30
62%
-88
- C4 -
1TYB
1
SYY_GEOSE
E:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
----
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
G
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
-------
G
R
F
L
D
----------
F
-
E
-
A
-----------
D
G---------
N
--
P
A
--
K
--
I
K
-
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
K
T
K
G
---------------------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
-
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
----
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
----------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.96
62%
-90
- C4 -
1TYA
1
SYY_GEOSE
E:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
----
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
A
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
-------
G
R
F
L
D
----------
F
-
E
-
A
-----------
D
G---------
N
--
P
A
--
K
--
I
K
-
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
K
T
K
G
---------------------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
-
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
----
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
----------------------------------------------------------------------------------------------------------
95
HHSearch
88.95
63%
-88
* C4 *
2TS1
-
SYY_GEOSE
A:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
----
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
-------
G
R
F
L
D
----------
F
-
E
-
A
D----------
G
----------
N
--
P
A
--
K
--
I
K
-
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
K
T
K
G
---------------------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
-
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
----
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
----------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
88.91
62%
-90
- C4 -
1TYD
1
SYY_GEOSE
E:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
----
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
S
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
-------
G
R
F
L
D
----------
F
-
E
-
A
-----------
D
G---------
N
--
P
A
--
K
--
I
K
-
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
K
T
K
G
---------------------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
-
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
----
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
----------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.79
62%
-90
- C4 -
3TS1
1
SYY_GEOSE
A:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
----
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
-------
G
R
F
L
D
----------
F
-
E
-
A
-----------
D
G---------
N
--
P
A
--
K
--
I
K
-
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
K
T
K
G
---------------------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
-
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
----
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
----------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.45
62%
-89
- C4 -
1TYC
-
SYY_GEOSE
A:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
----
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
P
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
-------
G
R
F
L
D
----------
F
-
E
-
A
-----------
D
G---------
N
--
P
A
--
K
--
I
K
-
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
K
T
K
G
---------------------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
-
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
----
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
----------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.42
62%
-88
- C4 -
2TS1
-
SYY_GEOSE
A:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
----
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
-------
G
R
F
L
D
----------
F
-
E
-
A
-----------
D
G---------
N
--
P
A
--
K
--
I
K
-
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
K
T
K
G
---------------------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
-
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
----
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
----------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.41
59%
-91
- C4 -
1JIL
1
SYY_STAAE
A:
[5-324]
--
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
D
E
Q
G
I
E
D
----
L
L
N
K
----
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
S
G
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
-------
H
N
I
F
E
----------
F
-
G
-
T
-----------
D
----------
H
--
G
A
--
V
--
L
V
-
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
---
E
---
H
--
G
--
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
R
M
Y
G
Q
----------------
T
---------------
D
A
Y
G
L
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
-
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
S
----
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
Q
A
L
F
------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
87.58
61%
-87
- C4 -
4TS1
1
SYY_GEOSE
A:
[1-319]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
----
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
-------
G
R
F
L
D
----------
F
-
E
-
A
-----------
D
G---------
N
--
P
A
--
K
--
I
K
-
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
K
T
K
G
---------------------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
-
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
----
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
Y
A
----------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.38
61%
-89
- C4 -
4TS1
1
SYY_GEOSE
B:
[1-313]
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
----
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
-------
G
R
F
L
D
----------
F
-
E
-
A
-----------
D
G---------
N
--
P
A
--
K
--
I
K
-
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
---
T
--
G
--
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
K
T
K
G
---------------------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
-
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
----
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.51
59%
-91
- C4 -
1JIJ
1
SYY_STAAE
A:
[5-320]
--
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
D
E
Q
G
I
E
D
----
L
L
N
K
----
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
S
G
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
-------
H
N
I
F
E
----------
F
-
G
-
T
-----------
D
----------
H
--
G
A
--
V
--
L
V
-
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
---
E
---
H
--
G
--
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
R
M
Y
G
Q
----------------
T
---------------
D
A
Y
G
L
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
-
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
S
----
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
----------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.88
59%
-82
- C4 -
1JIK
1
SYY_STAAE
A:
[5-320]
--
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
D
E
Q
G
I
E
D
----
L
L
N
K
----
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
S
G
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
-------
H
N
I
F
E
----------
F
-
G
-
T
-----------
D
----------
H
--
G
A
--
V
--
L
V
-
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
---
E
---
H
--
G
--
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
R
M
Y
G
Q
----------------
T
---------------
D
A
Y
G
L
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
-
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
S
----
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
----------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.65
59%
-87
- C4 -
1JII
1
SYY_STAAE
A:
[5-320]
--
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
D
E
Q
G
I
E
D
----
L
L
N
K
----
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
S
G
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
-------
H
N
I
F
E
----------
F
-
G
-
T
-----------
D
----------
H
--
G
A
--
V
--
L
V
-
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
---
E
---
H
--
G
--
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
R
M
Y
G
Q
----------------
T
---------------
D
A
Y
G
L
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
-
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
S
----
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
----------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
84.46
51%
-85
- C4 -
1X8X
2
SYY_ECOLI
A:
[5-320]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
----
G
P
I
A
L
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
-------
A
P
F
L
D
----------
F
-
D
C
G
-----------
E
----------
N
--
S
A
--
I
--
A
A
-
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
RE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
R
L
H
-----
Q
------------
N
---------------
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
-
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
----
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
--------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.25
51%
-89
- C4 -
1VBM
3
SYY_ECOLI
B:
[1-316]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
----
G
P
I
A
L
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
-------
A
P
F
L
D
----------
F
-
D
C
G
-----------
E
----------
N
--
S
A
--
I
--
A
A
-
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
NRE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
R
L
H
-----
Q
------------
N
---------------
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
-
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
----
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
--------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
84.25
51%
-85
- C4 -
1WQ4
1
SYY_ECOLI
A:
[4-319]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
----
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
-------
A
P
F
L
D
----------
F
-
D
C
G
-----------
E
----------
N
--
S
A
--
I
--
A
A
-
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
RE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
R
L
H
-----
Q
------------
N
---------------
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
-
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
----
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
--------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
84.21
51%
-85
- C4 -
2YXN
1
SYY_ECOLI
A:
[5-320]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
----
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
-------
A
P
F
L
D
----------
F
-
D
C
G
-----------
E
----------
N
--
S
A
--
I
--
A
A
-
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
RE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
R
L
H
-----
Q
------------
N
---------------
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
-
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
----
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
--------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
84.21
51%
-85
- C4 -
1WQ3
1
SYY_ECOLI
A:
[5-320]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
----
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
-------
A
P
F
L
D
----------
F
-
D
C
G
-----------
E
----------
N
--
S
A
--
I
--
A
A
-
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
RE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
R
L
H
-----
Q
------------
N
---------------
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
-
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
----
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
--------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
83.94
51%
-89
- C4 -
1VBN
1
SYY_ECOLI
A:
[1-316]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
----
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
-------
A
P
F
L
D
----------
F
-
D
C
G
-----------
E
----------
N
--
S
A
--
I
--
A
A
-
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
RE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
R
L
H
-----
Q
------------
N
---------------
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
-
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
----
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
--------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
83.80
51%
-87
- C4 -
1VBM
3
SYY_ECOLI
A:
[1-316]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
----
G
P
I
A
L
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
-------
A
P
F
L
D
----------
F
-
D
C
G
-----------
E
----------
N
--
S
A
--
I
--
A
A
-
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
NRE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
R
L
H
-----
Q
------------
N
---------------
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
-
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
----
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
--------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.40
51%
-87
- C4 -
1VBN
1
SYY_ECOLI
B:
[1-316]
-
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
----
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
-------
A
P
F
L
D
----------
F
-
D
C
G
-----------
E
----------
N
--
S
A
--
I
--
A
A
-
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
NRE
D
---
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
R
L
H
-----
Q
------------
N
---------------
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
-
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
----
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
--------------------------------------------------------------------------------------------------------------
100
HHSearch
80.60
48%
-84
- C4 -
2YXN
1
SYY_ECOLI
A:
[4-322]
S
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
----
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
-------
A
P
F
------------
L
-
D
-
F
D----------
C
----------
G
EN
S
A
--
I
--
A
A
-
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
---
N
RED
Q
--
G
--
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
R
L
H
Q
-----------------
N
---------------
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
-
G
A
V
W
L
-
D
---
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
TA
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
------------------------------------------------------------------------------------------------------------
99
HHSearch
79.11
41%
-89
- C4 -
2PID
1
SYYM_HUMAN
A:
[10-346]
-
G
L
L
A
A
Q
K
A
R
G
L
F
K
D
F
F
P
E
T
G
T
K
I
ELPE
L
F
-------
P
Q
T
I
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
----------
L
E
A
----------
L
-
A
-
A
N
----------
H
Q
Q
LFTDGRSW
G
--
S
F
--
T
--
V
L
-
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
---
K
SP-
E
--
G
--
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
K
L
T
G
-----------------
E
---------------
D
V
F
G
I
T
V
P
L
I
T
---------------
A
V
W
L
N
R
D
K
T
S
P
F
E
L
Y
Q
F
F
V
R
Q
P
----
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
74.99
43%
-93
- C4 -
2PID
1
SYYM_HUMAN
B:
[48-346]
---------------------------------------
T
I
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
N
H
Q
Q
L
F
T
------------
D
-
G
-----------
R
----------
S
--
W
G
--
S
F
T
V
L
-
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
---
K
---
S
PE
G
--
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
K
L
T
G
E
---
D
------------
V
-----------------
F
G
I
T
V
P
L
I
T
---------------
A
V
W
L
N
R
D
K
T
S
P
F
E
L
Y
Q
F
F
V
R
Q
P
----
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
74.83
43%
-90
- C4 -
2PID
1
SYYM_HUMAN
A:
[48-346]
---------------------------------------
T
I
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
N
H
Q
Q
L
F
T
------------
D
-
G
-----------
R
----------
S
--
W
G
--
S
F
T
V
L
-
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
---
K
---
S
PE
G
--
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
K
L
T
G
E
---
D
------------
V
-----------------
F
G
I
T
V
P
L
I
T
---------------
A
V
W
L
N
R
D
K
T
S
P
F
E
L
Y
Q
F
F
V
R
Q
P
----
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-------------------------------------------------------------------------------------------------------
98
HHSearch
74.37
34%
-83
- C4 -
1Y42
1
SYYM_NEUCR
X:
[35-388]
-
N
T
W
D
L
F
E
E
R
G
Y
V
K
D
T
A
G
T
K
E
H
I
A
E---
L
M
R
T
----
R
R
I
G
A
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
T
G
-----------
D
A
T
M
N
M
T
K
I
H
Y
Q
L
-------
K
K
L
W
E
----------
N
V
D
-
T
QMRARGYEADW
A
----------
R
--
K
R
--
G
--
I
V
-
N
N
N
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
---
T
QG-
D
--
G
--
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
A
A
R
E
S
EPD
P
QERKYVTPKTAL
D
---------------
E
C
V
G
F
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
S
A
-
G
-
N
A
I
W
L
D
P
Y
Q
T
S
V
F
D
F
Y
G
Y
F
V
R
R
S
----
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
M
E
E
H
I
K
D
P
S
K
R
V
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
T
-
G
---------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.19
32%
-81
- C4 -
4OJM
1
SYYM_NEUCR
X:
[35-390]
-
N
T
W
D
L
F
E
E
R
G
Y
V
---
K
D
T
A
G
T
K
E
----
H
I
A
E
LMRT
R
R
I
G
A
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
T
G
--------
S
S
S
D
A
T
M
N
M
T
K
I
H
Y
Q
L
-------
K
K
L
W
E
NVDTQMRARG
Y
-
E
-
A
-----------
D
----------
W
--
A
R
KR
G
--
I
V
-
N
N
N
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
---
T
---
Q
--
G
DG
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
A
A
R
E
S
---
E
------------
P
DPQERKYVTPKTALD
E
C
V
G
F
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
S
A
-
G
-
N
A
I
W
L
D
P
Y
Q
T
S
V
F
D
F
Y
G
Y
F
V
R
R
S
----
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
M
E
E
H
I
K
D
P
S
K
R
V
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
T
-
G
Q
M
-------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
72.19
32%
-81
- C4 -
1Y42
1
SYYM_NEUCR
X:
[35-388]
-
N
T
W
D
L
F
E
E
R
G
Y
V
---
K
D
T
A
G
T
K
E
----
H
I
A
E
LMRT
R
R
I
G
A
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
T
G
-----------
D
A
T
M
N
M
T
K
I
H
Y
Q
L
-------
K
K
L
W
E
NVDTQMRARG
Y
-
E
-
A
-----------
D
----------
W
--
A
R
KR
G
--
I
V
-
N
N
N
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
---
T
---
Q
--
G
DG
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
A
A
R
E
S
---
E
------------
P
DPQERKYVTPKTALD
E
C
V
G
F
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
S
A
-
G
-
N
A
I
W
L
D
P
Y
Q
T
S
V
F
D
F
Y
G
Y
F
V
R
R
S
----
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
M
E
E
H
I
K
D
P
S
K
R
V
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
T
-
G
---------------------------------------------------------------------------------------------------