@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1633: (2016-03-27 )
MRKMKKMDADTLTAILAFQRLSGTGKSLLEGAAKDAEAGRYSIIAINPVHEIKVYQHDYYIDGTHQVVADPLKEIELFIEKAREDELELPLDSGAIGYVGYDVIALYEDLGEIPVETRDIPDIRFYVYESFVIMDHQAEELILVQDNCYSGRSEADLDKALESMLTELTTPKKDEHKAVHVPKMSYKSNYTKDEYMGLVKKAKTYIQEGDFFQIVLSQRLEADFTVKPFDYYRKLRLLNPSPYLYFIDFGDTVLIGSSPESLIKTKGRTVITNPIAGTRRRGATKQEDELLASELLSDEKELAEHRMLVDLGRNDIGKIAETGSVHVPVYLTIERYRFLMHLVSVVEGTLKTGLTAIDALRSTLPAGTVSGAPKIRAMERIYEWENVKRGPYAGAVGYLTKNGDSDFALSIRTMVLHNGKAYVQAGAGIVYDSDPESEYLETLQKAKALLEVGE
Atome Classification :
(23 SA)
---.........10...-.....20-..--.--...-..30........40........50........60-.---.---.----.---------------------------------------.---...70.......-----.80---..--.---.-....-.90...-------------------------------------......100.......110......----------------.120.......130.......140.......--150---------.-....-...160-----.........170........-180.......190.......200......---.210.......220..--.--....230.......240.......-250----..-.......260....--.--.--...270.......280..------...------..290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450..-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MR
K
M
K
KM
D
A
D
T
L
T
A
-
I
L
A
F
Q
R
L-SG--T--
G
K
S
-
L
L
E
GAAKDAEAG
R
Y
S
I
I
A
INP
V
H
E
I
K
V
Y
Q
H
D
Y
Y
I-D---G---
T
----
H
---------------------------------------
Q
---
V
V
A
D
P
L
K
E
I
E
L
F
-----
I
E
----
K
A--R---E-DELE-LP-LDS-------------------------------------GA
I
G
Y
V
G
Y
D
V
I
A
L
Y
E
D
L
GEIPVETR----------------DIP
D
I
R
F
Y
V
Y
E
S
F
V
I
MDHQA
E
E
L
I
L
VQDNCY--SG----------R-S
E
A
D
-
L
D
K
A
-------
L
E
S
M
L
T
E
LTT-PKKDEHKAV-HVPKMSYKSNY
T
K
D
E
Y
M
G
L
V
K
K
A
K
T
Y
IQE---G
D
F
F
Q
I
V
L
S
QRLEADF--T--V
K
P
F
D
Y
Y
R
K
L
RLLNPS
P
Y
L
Y
F
I
DF-G------
D
T
-
V
L
IGSS
P
E
--
S
L
I
K--T--K--G
R
T
V
I
TNPIAGTRRRGAT------
K
Q
E
------
D
E
L
L
A
S
E
L
LS
D
E
K
E
L
A
E
H
R
M
L
V
DLGR
N
D
I
G
K
IAETG
S
V
H
V
P
V
Y
L
T
I
E
R
Y
R
F
L
M
H
L
V
S
V
V
E
G
T
L
K
T
G
L
T
A
I
D
A
L
R
STLPAGTVSGA
P
K
I
R
A
M
E
R
I
Y
E
W
ENVKRGPYAGA
V
G
Y
L
TKNGDS
D
F
A
L
S
I
R
T
M
V
LHNG
K
A
Y
V
Q
AG
A
G
I
V
YDSDP
E
S
E
Y
L
E
T
L
Q
K
A
K
A
L
L
EVGE-----
1
PsiBlast_PDB
97.93
38%
-80
- C3 -
5CWA
6
?
A:
[30-500]
-------
R
K
V
L
A
D
S
E
T
P
-
L
S
A
Y
R
K
L
-
A
A
--
N
RP
G
T
F
-
L
L
E
S
A
E
N
G
R
S
W
S
R
W
S
F
I
G
A
G
A
P
T
A
L
T
V
R
E
G
Q
A
V
W
-
L
---
G
---
A
VPKD
A
---------------------------------------
P
---
T
G
G
D
P
L
R
A
L
Q
V
T
-----
L
E
L
L
AT
A
D
----------
P
G
-
L
P
P
L
S
G
-------------------------------------
G
M
V
G
F
F
A
Y
D
M
V
R
R
L
E
R
L
P
E
R
A
V
D
D
L
----------------
C
L
P
D
M
L
L
L
L
A
T
D
V
A
A
V
D
H
H
E
G
T
I
T
L
I
A
N
A
V
N
--
W
N
----------
G
-
T
D
E
R
-
V
D
W
A
Y
D
D
A
V
A
R
L
D
V
M
T
A
A
L
G
Q
-
P
L
P
S
T
V
A
T
F
-
S
R
P
E
P
R
H
R
A
Q
R
T
V
E
E
Y
G
A
I
V
E
Y
L
V
D
Q
I
A
A
---
G
E
A
F
Q
V
V
P
S
Q
R
F
E
M
D
T
--
D
--
V
D
P
I
D
V
Y
R
I
L
R
V
T
N
P
S
P
Y
M
Y
L
L
Q
V
-
P
N
SDGAV
D
F
-
S
I
V
G
S
S
P
E
--
A
L
V
T
--
V
--
H
--
E
G
W
A
T
T
H
P
I
A
G
T
R
W
R
G
R
T
------
D
D
E
------
D
V
L
L
E
K
E
L
L
A
D
D
K
E
R
A
E
H
L
M
L
V
D
L
G
R
N
D
L
G
R
V
C
T
P
G
T
V
R
V
E
D
Y
S
H
I
E
R
Y
S
H
V
M
H
L
V
S
T
V
T
G
K
L
G
E
G
R
T
A
L
D
A
V
T
A
C
F
P
A
G
T
L
S
G
A
P
K
V
R
A
M
E
L
I
E
E
V
E
K
T
R
R
G
L
Y
G
G
V
V
G
Y
L
D
F
A
G
N
A
D
F
A
I
A
I
R
T
A
L
M
R
N
G
T
A
Y
V
Q
A
G
G
G
V
V
A
D
S
N
G
S
Y
E
Y
N
E
A
R
N
K
A
R
A
V
L
N
--------
46
HHSearch
93.96
35%
-62
- C3 -
1I1Q
1
TRPE_SALTY
A:
[11-511]
------
L
T
C
D
A
A
Y
R
E
N
P
-
T
A
L
F
H
Q
V
-
C
G
DR
P
--
A
T
L
-
L
L
E
S
A
D
I
D
S
K
D
D
L
K
S
L
L
L
V
D
S
A
L
R
I
T
A
L
G
D
T
V
T
I
Q
A
---
L
S
D
N
G
----
A
S
L
L
P
L
L
D
T
A
LPAG
V
E
N
D
V
L
PA
G
R
V
L
R
F
P
P
V
S
PLLD
E
N
A
R
L
---
C
S
L
S
V
F
D
A
F
R
L
L
-----
Q
G
----
V
V
--
N
I
--
P
T
Q
E
R
E
-
A
M
-
F
F
G
----------------------------------------
G
L
F
A
Y
D
L
V
A
G
F
E
A
L
P
H
L
-
E
A
G
N
----------------
N
C
P
D
Y
C
F
Y
L
A
E
T
L
M
V
I
D
H
Q
K
K
S
T
R
I
Q
A
S
L
F
T
--
A
S
----------
D
R
E
K
Q
R
-
L
N
A
R
-------
L
A
Y
L
S
Q
Q
L
T
Q
-
P
A
P
P
--
L
P
V
T
P
V
P
D
M
R
C
E
C
N
Q
S
D
D
A
F
G
A
V
V
R
Q
L
Q
K
A
I
R
A
---
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
--
P
---
S
P
L
A
A
Y
Y
V
L
K
K
S
N
P
S
P
Y
M
F
F
M
Q
D
-
N
------
D
F
-
T
L
F
G
A
S
P
E
--
S
S
L
K
--
Y
--
D
AA
S
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
ADGTLD
R
D
L
------
D
S
R
I
E
L
D
M
R
T
D
H
K
E
L
S
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
T
P
G
S
R
Y
V
A
D
L
T
K
V
D
R
Y
S
Y
V
M
H
L
V
S
R
V
V
G
E
L
R
H
D
L
D
A
L
H
A
Y
R
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
D
A
E
G
Q
R
R
G
S
Y
G
G
A
V
G
Y
F
T
A
H
G
D
L
D
T
C
I
V
I
R
S
A
L
V
E
N
G
I
A
T
V
Q
A
G
A
G
I
V
L
D
S
V
P
Q
S
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
I
A
-----
58
Fugue
92.69
33%
-65
- C3 -
1I1Q
1
TRPE_SALTY
A:
[5-516]
K
P
T
L
E
L
L
T
C
D
A
A
Y
R
E
N
P
-
T
A
L
F
H
Q
V
-
C
G
--
D
RP
A
T
L
-
L
L
E
S
A
D
I
D
S
K
D
D
L
K
S
L
L
L
V
D
S
A
L
R
I
T
A
L
G
D
T
V
T
I
-
Q
---
A
---
L
----
S
---------------------------------------
D
---
N
G
A
S
L
L
P
L
L
D
T
A
LPAG
V
E
N
----
D
V
--
L
---
P
-
A
G
R
V
-
L
R
-
F
P
P
V
S
PLLD
E
N
A
R
L
C
SLSVFD
A
F
R
L
L
Q
G
V
V
N
I
P
TQEREA
M
F
F
G
G
L
F
A
Y
D
L
V
A
G
F
E
A
L
P
H
L
E
-
A
G
N
----------------
N
C
P
D
Y
C
F
Y
L
A
E
T
L
M
V
I
D
H
Q
K
K
S
T
R
I
Q
A
S
L
F
T
--
A
S
----------
D
-
R
E
K
Q
-
R
L
N
A
-------
R
L
A
Y
L
S
Q
Q
L
T
-
Q
P
A
P
P
L
P
V
T
-
P
V
P
D
M
R
C
E
C
N
Q
S
D
D
A
F
G
A
V
V
R
Q
L
Q
K
A
I
R
A
---
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
--
P
---
S
P
L
A
A
Y
Y
V
L
K
K
S
N
P
S
P
Y
M
F
F
M
Q
D
-
N
------
D
F
-
T
L
F
G
A
S
P
E
--
S
S
L
K
--
Y
D
A
A
--
S
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
ADGTLD
R
D
L
------
D
S
R
I
E
L
D
M
R
T
D
H
K
E
L
S
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
T
P
G
S
R
Y
V
A
D
L
T
K
V
D
R
Y
S
Y
V
M
H
L
V
S
R
V
V
G
E
L
R
H
D
L
D
A
L
H
A
Y
R
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
D
A
E
G
Q
R
R
G
S
Y
G
G
A
V
G
Y
F
T
A
H
G
D
L
D
T
C
I
V
I
R
S
A
L
V
E
N
G
I
A
T
V
Q
A
G
A
G
I
V
L
D
S
V
P
Q
S
E
A
D
E
T
R
N
K
A
R
A
V
L
R
A
I
A
T
A
H
HA
44
HHSearch
91.49
32%
-73
- C3 -
1K0E
2
PABB_ECOLI
A:
[10-452]
--------
T
L
L
W
R
Q
-
D
A
A
E
F
Y
F
S
R
L
-
S
H
L-
P
--
W
A
M
-
L
L
H
S
G
Y
A
D
H
P
Y
S
R
F
D
I
V
V
A
E
P
I
C
T
L
T
T
F
G
K
E
T
V
V
S
E
---
S
E
K
-
R
----
T
---------------------------------------
T
---
T
T
D
D
P
L
Q
V
L
Q
Q
V
-----
L
D
----
R
A
--
D
IR-
P
T
H
N
E
D
-
L
P
-
F
Q
G
-------------------------------------
G
A
L
G
L
F
G
Y
D
L
G
R
R
F
E
S
L
P
E
I
A
E
Q
D
I
----------------
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
N
D
V
--
N
A
----------
R
-----------------
R
A
W
L
E
S
Q
Q
F
S
-
P
-----
Q
E
D
-
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
---
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
--
S
--
G
D
E
W
Q
A
F
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
-
E
------
Q
G
-
A
I
L
S
L
S
P
E
--
R
F
I
L
--
C
--
D
--
N
S
E
I
Q
T
R
P
I
K
G
T
L
P
R
--------------------------
A
N
S
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
V
E
P
F
P
A
V
H
H
L
V
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
Q
L
E
-----
61
Fugue
91.45
31%
-68
- C3 -
1K0E
2
PABB_ECOLI
A:
[3-453]
-TL
S
P
A
V
I
T
L
L
W
R
Q
D
A
A
-
E
F
Y
F
S
R
L
S
H
L
--
P
--
W
A
M
-
L
L
H
S
G
Y
A
D
H
P
Y
S
R
F
D
I
V
V
A
E
P
I
C
T
L
T
T
F
G
K
E
T
V
V
-
S
E
SE
K
---
R
----
T
---------------------------------------
T
---
T
T
D
D
P
L
Q
V
L
Q
Q
V
-----
L
D
----
R
A
--
D
IRP
T
-
H
N
E
D
-
L
P
-
F
Q
G
-------------------------------------
G
A
L
G
L
F
G
Y
D
L
G
R
R
F
E
S
L
P
E
I
A
E
Q
D
I
----------------
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
N
---------------------
D
-
V
N
A
R
-------
R
A
W
L
E
S
Q
Q
F
S
-
P
Q
E
D
F
T
L
------
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
---
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
--
S
--
G
D
E
W
Q
A
F
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
-
E
------
Q
G
-
A
I
L
S
L
S
P
E
--
R
F
I
L
--
C
--
D
--
N
S
E
I
Q
T
R
P
I
K
G
T
L
P
R
A
--------------------------
N
S
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
V
E
P
F
P
A
V
H
H
L
V
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
Q
L
E
K----
3
PsiBlast_PDB
89.82
31%
-71
- C3 -
1K0E
2
PABB_ECOLI
A:
[22-449]
---------------------
F
S
R
L
-
S
H
--
L
--
P
W
A
M
L
L
H
S
G
Y
A
D
H
P
Y
S
R
F
D
I
V
V
A
E
P
I
C
T
L
T
T
F
G
K
E
T
V
V
-
S
---
E
---
S
----
E
---------------------------------------
K
R
T
T
T
T
D
D
P
L
Q
V
L
Q
Q
V
-----
L
D
----
R
A
DI
R
---
P
-
T
H
N
E
D
L
P
-
F
Q
G
-------------------------------------
G
A
L
G
L
F
G
Y
D
L
G
R
R
F
E
S
L
P
E
I
A
E
Q
D
I
----------------
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
N
---------------------
D
-
V
N
A
R
-------
R
A
W
L
E
S
Q
Q
F
S
-
P
Q
E
D
------
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
---
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
--
S
--
G
D
E
W
Q
A
F
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
-
E
------
Q
G
-
A
I
L
S
L
S
P
E
--
R
F
I
L
--
C
--
D
--
N
S
E
I
Q
T
R
P
I
K
G
T
L
P
R
--------------------------
A
N
S
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
V
E
P
F
P
A
V
H
H
L
V
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
--------
21
PsiBlast_CBE
86.97
31%
-73
- C3 -
1K0G
2
PABB_ECOLI
B:
[22-449]
---------------------
F
S
R
L
-
S
H
--
L
--
P
W
A
M
L
L
H
S
G
Y
A
D
H
P
Y
S
R
F
D
I
V
V
A
E
P
I
C
T
L
T
T
F
G
K
E
T
V
V
-
S
---
E
---
S
----
E
---------------------------------------
K
R
T
T
T
T
D
D
P
L
Q
V
L
Q
Q
V
-----
L
D
----
R
A
DI
R
---
P
-
T
H
N
E
D
L
P
-
F
Q
G
-------------------------------------
G
A
L
G
L
F
G
Y
D
L
G
R
R
F
E
S
L
P
E
I
A
E
Q
D
I
----------------
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
N
---------------------
D
-
V
N
A
R
-------
R
A
W
L
E
S
Q
Q
F
S
-
P
Q
E
D
------
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
---
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
--
S
--
G
D
E
W
Q
A
F
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
-
E
------
Q
G
-
A
I
L
S
L
S
P
E
--
R
F
I
L
--
C
--
D
--
N
S
E
I
Q
T
R
P
I
K
G
-------------------------------------
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
-----------
L
V
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
--------
5
PsiBlast_PDB
86.57
38%
-75
- C3 -
1I7Q
4
TRPE_SERMA
A:
[147-506]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
F
A
Y
D
L
V
A
G
F
E
N
L
P
A
L
R
Q
D
Q
R
-----------------
C
P
D
F
C
F
Y
L
A
E
T
L
L
V
L
D
H
Q
R
G
S
A
R
L
-
Q
A
S
V
F
--
S
E
----------
Q
A
S
E
A
Q
R
L
Q
H
R
-------
L
E
Q
L
Q
A
E
L
Q
Q
--
P
P
Q
P
I
P
H
Q
-
K
L
E
N
M
Q
L
S
C
N
Q
S
D
E
E
Y
G
A
V
V
S
E
L
Q
E
A
I
R
Q
---
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
--
P
--
A
-
P
L
G
P
Y
Q
T
L
K
D
N
N
P
S
P
Y
M
F
F
M
Q
D
-
D
------
D
F
-
T
L
F
G
A
S
P
E
--
S
A
L
K
Y
D
A
--
G
--
N
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
------
A
D
G
SLD
L
D
L
D
S
R
I
E
L
E
M
R
T
D
H
K
E
L
A
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
Q
A
G
S
R
Y
V
A
D
L
T
K
V
D
R
Y
S
F
V
M
H
L
V
S
R
V
V
G
T
L
R
A
D
L
D
V
L
H
A
Y
Q
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
A
L
R
S
T
R
R
G
S
Y
G
G
R
V
G
Y
F
T
A
V
R
N
L
D
T
C
I
V
I
R
S
A
Y
V
E
D
G
H
R
T
V
Q
A
G
A
G
V
V
Q
D
S
I
P
E
R
E
A
D
E
T
R
N
K
A
R
A
V
L
---------
24
PsiBlast_CBE
86.51
38%
-76
- C3 -
1I7Q
4
TRPE_SERMA
C:
[147-506]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
F
A
Y
D
L
V
A
G
F
E
N
L
P
A
L
R
Q
D
Q
R
-----------------
C
P
D
F
C
F
Y
L
A
E
T
L
L
V
L
D
H
Q
R
G
S
A
R
L
-
Q
A
S
V
F
--
S
E
----------
Q
A
S
E
A
Q
R
L
Q
H
R
-------
L
E
Q
L
Q
A
E
L
Q
Q
--
P
P
Q
P
I
P
H
Q
-
K
L
E
N
M
Q
L
S
C
N
Q
S
D
E
E
Y
G
A
V
V
S
E
L
Q
E
A
I
R
Q
---
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
--
P
--
A
-
P
L
G
P
Y
Q
T
L
K
D
N
N
P
S
P
Y
M
F
F
M
Q
D
-
D
------
D
F
-
T
L
F
G
A
S
P
E
--
S
A
L
K
YD
A
--
G
--
N
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
------
A
D
G
SLDLDL
D
S
R
I
E
L
E
M
R
T
D
H
K
E
L
A
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
Q
A
G
S
R
Y
V
A
D
L
T
K
V
D
R
Y
S
F
V
M
H
L
V
S
R
V
V
G
T
L
R
A
D
L
D
V
L
H
A
Y
Q
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
A
L
R
S
T
R
R
G
S
Y
G
G
R
V
G
Y
F
T
A
V
R
N
L
D
T
C
I
V
I
R
S
A
Y
V
E
D
G
H
R
T
V
Q
A
G
A
G
V
V
Q
D
S
I
P
E
R
E
A
D
E
T
R
N
K
A
R
A
V
L
---------
22
PsiBlast_CBE
86.36
31%
-75
- C3 -
1K0E
1
PABB_ECOLI
B:
[22-449]
---------------------
F
S
R
L
-
S
H
--
L
--
P
W
A
M
L
L
H
S
G
Y
A
D
H
P
Y
S
R
F
D
I
V
V
A
E
P
I
C
T
L
T
T
F
G
K
E
T
V
V
-
S
---
E
---
S
----
E
---------------------------------------
K
R
T
T
T
T
D
D
P
L
Q
V
L
Q
Q
V
-----
L
D
----
R
A
DI
R
---
P
-
T
H
N
E
D
L
P
-
F
Q
G
-------------------------------------
G
A
L
G
L
F
G
Y
D
L
G
R
R
F
E
S
L
P
E
I
A
E
Q
D
I
----------------
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
N
---------------------
D
-
V
N
A
R
-------
R
A
W
L
E
S
Q
Q
F
S
-
P
Q
E
D
------
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
---
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
--
S
--
G
D
E
W
Q
A
F
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
-
E
------
Q
G
-
A
I
L
S
L
S
P
E
--
R
F
I
L
--
C
--
D
--
N
S
E
I
Q
T
R
-------------------------------------
A
K
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
--------------
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
--------
6
PsiBlast_PDB
86.08
38%
-75
- C3 -
1I7S
1
TRPE_SERMA
A:
[147-506]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
F
A
Y
D
L
V
A
G
F
E
N
L
P
A
L
R
Q
D
Q
R
-----------------
C
P
D
F
C
F
Y
L
A
E
T
L
L
V
L
D
H
Q
R
G
S
A
R
L
-
Q
A
S
V
F
--
S
E
----------
Q
A
S
E
A
Q
R
L
Q
H
R
-------
L
E
Q
L
Q
A
E
L
Q
Q
--
P
P
Q
P
I
P
H
Q
-
K
L
E
N
M
Q
L
S
C
N
Q
S
D
E
E
Y
G
A
V
V
S
E
L
Q
E
A
I
R
Q
---
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
--
P
--
A
-
P
L
G
P
Y
Q
T
L
K
D
N
N
P
S
P
Y
M
F
F
M
Q
D
-
D
------
D
F
-
T
L
F
G
A
S
P
E
--
S
A
L
K
Y
D
A
--
G
--
N
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
------
A
D
G
SLD
L
D
L
D
S
R
I
E
L
E
M
R
T
D
H
K
E
L
A
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
Q
A
G
S
R
Y
V
A
D
L
T
K
V
D
R
Y
S
F
V
M
H
L
V
S
R
V
V
G
T
L
R
A
D
L
D
V
L
H
A
Y
Q
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
A
L
R
S
T
R
R
G
S
Y
G
G
R
V
G
Y
F
T
A
V
R
N
L
D
T
C
I
V
I
R
S
A
Y
V
E
D
G
H
R
T
V
Q
A
G
A
G
V
V
Q
D
S
I
P
E
R
E
A
D
E
T
R
N
K
A
R
A
V
L
---------
2
PsiBlast_PDB
85.80
39%
-71
- C3 -
1I1Q
1
TRPE_SALTY
A:
[148-507]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
F
A
Y
D
L
V
A
G
F
E
A
L
P
H
L
E
A
G
N
-----------------
N
C
P
D
Y
C
F
Y
L
A
E
T
L
M
V
I
D
H
Q
K
K
S
-
T
R
I
Q
A
S
L
F
TA
S
D
----------
R
-
E
K
Q
R
-
L
N
A
R
-------
L
A
Y
L
S
Q
Q
L
T
Q
-
P
A
P
-
P
L
P
V
T
-
P
V
P
D
M
R
C
E
C
N
Q
S
D
D
A
F
G
A
V
V
R
Q
L
Q
K
A
I
R
A
---
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
---
C
--
P
S
P
L
A
A
Y
Y
V
L
K
K
S
N
P
S
P
Y
M
F
F
M
Q
D
-
N
------
D
F
-
T
L
F
G
A
S
P
E
--
S
S
L
K
Y
D
A
--
A
--
S
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
ADGTLD
R
D
L
------
D
S
R
I
E
L
D
M
R
T
D
H
K
E
L
S
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
T
P
G
S
R
Y
V
A
D
L
T
K
V
D
R
Y
S
Y
V
M
H
L
V
S
R
V
V
G
E
L
R
H
D
L
D
A
L
H
A
Y
R
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
D
A
E
G
Q
R
R
G
S
Y
G
G
A
V
G
Y
F
T
A
H
G
D
L
D
T
C
I
V
I
R
S
A
L
V
E
N
G
I
A
T
V
Q
A
G
A
G
I
V
L
D
S
V
P
Q
S
E
A
D
E
T
R
N
K
A
R
A
V
L
---------
4
PsiBlast_PDB
85.48
31%
-69
- C3 -
1K0G
2
PABB_ECOLI
A:
[22-449]
---------------------
F
S
R
L
-
S
H
--
L
--
P
W
A
M
L
L
H
S
G
Y
A
D
H
P
Y
S
R
F
D
I
V
V
A
E
P
I
C
T
L
T
T
F
G
K
E
T
V
V
-
S
---
E
---
S
----
E
---------------------------------------
K
R
T
T
T
T
D
D
P
L
Q
V
L
Q
Q
V
-----
L
D
----
R
A
DI
R
---
P
-
T
H
N
E
D
L
P
-
F
Q
G
-------------------------------------
G
A
L
G
L
F
G
Y
D
L
G
R
R
F
E
S
L
P
E
I
A
E
Q
D
I
----------------
V
L
P
D
M
A
V
G
I
Y
D
W
A
L
I
V
D
H
Q
R
H
T
V
S
L
L
S
H
N
---------------------
D
-
V
N
A
R
-------
R
A
W
L
E
S
Q
Q
F
S
-
P
Q
E
D
------
F
T
L
T
S
D
W
Q
S
N
M
T
R
E
Q
Y
G
E
K
F
R
Q
V
Q
E
Y
L
H
S
---
G
D
C
Y
Q
V
N
L
A
Q
R
F
H
A
T
Y
--
S
--
G
D
E
W
Q
A
F
L
Q
L
N
Q
A
N
R
A
P
F
S
A
F
L
R
L
-
E
------
Q
G
-
A
I
L
S
L
S
P
E
--
R
F
I
L
--
C
--
D
--
N
S
E
I
Q
T
R
P
I
K
------------------------------------
D
R
A
E
N
L
M
I
V
D
L
M
R
N
D
I
G
R
V
A
V
A
G
S
V
K
V
P
E
L
F
V
---------
L
V
S
T
I
T
A
Q
L
P
E
Q
L
H
A
S
D
L
L
R
A
A
F
P
G
G
S
I
T
G
A
P
K
V
R
A
M
E
I
I
D
E
L
E
P
Q
R
R
N
A
W
C
G
S
I
G
Y
L
S
F
C
G
N
M
D
T
S
I
T
I
R
T
L
T
A
I
N
G
Q
I
F
C
S
A
G
G
G
I
V
A
D
S
Q
E
E
A
E
Y
Q
E
T
F
D
K
V
N
R
I
L
K
--------
23
PsiBlast_CBE
84.45
38%
-74
- C3 -
1I7S
1
TRPE_SERMA
C:
[147-506]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
F
A
Y
D
L
V
A
G
F
E
N
L
P
A
L
R
Q
D
Q
R
-----------------
C
P
D
F
C
F
Y
L
A
E
T
L
L
V
L
D
H
Q
R
G
S
A
R
L
-
Q
A
S
V
F
--
S
E
----------
Q
A
S
E
A
Q
R
L
Q
H
R
-------
L
E
Q
L
Q
A
E
L
Q
Q
--
P
P
Q
P
I
P
H
Q
-
K
L
E
N
M
Q
L
S
C
N
Q
S
D
E
E
Y
G
A
V
V
S
E
L
Q
E
A
I
R
Q
---
G
E
I
F
Q
V
V
P
S
R
R
F
S
L
P
C
--
P
--
A
-
P
L
G
P
Y
Q
T
L
K
D
N
N
P
S
P
Y
M
F
F
M
Q
D
-
D
------
D
F
-
T
L
F
G
A
S
P
E
--
S
A
L
K
YD
A
--
G
--
N
R
Q
I
E
I
Y
P
I
A
G
T
R
P
R
G
R
R
------
A
D
G
SLDLDL
D
S
R
I
E
L
E
M
R
T
D
H
K
E
L
A
E
H
L
M
L
V
D
L
A
R
N
D
L
A
R
I
C
Q
A
G
S
R
Y
V
A
D
L
T
K
V
D
R
Y
S
F
V
M
H
L
V
S
R
V
V
G
T
L
R
A
D
L
D
V
L
H
A
Y
Q
A
C
M
N
M
G
T
L
S
G
A
P
K
V
R
A
M
Q
L
I
A
A
L
R
S
T
R
R
G
S
Y
G
G
R
V
G
Y
F
T
A
V
R
N
L
D
T
C
I
V
I
R
S
A
Y
V
E
D
G
H
R
T
V
Q
A
G
A
G
V
V
Q
D
S
I
P
E
R
E
A
D
E
T
R
N
K
A
R
A
V
L
---------
45
HHSearch
75.24
38%
-84
- C- -
1QDL
-
TRPE_SULSO
A:
[2-419]
------
E
V
H
P
I
S
E
F
A
S
P
-
F
E
V
F
K
C
I
-
E
R
D
F
K
--
V
A
G
-
L
L
E
S
I
G
------
R
Y
S
V
I
A
W
S
T
N
G
Y
L
K
I
------------------------------------------------------------------
H
D
D
P
V
N
I
L
N
G
Y
-----
L
K
----
D
L
--
K
---
L
-
A
D
I
P
-
G
L
-
F
K
G
-------------------------------------
G
M
I
G
Y
I
S
Y
D
A
V
R
F
W
E
K
I
R
D
L
K
P
A
A
E
----------------
D
W
P
Y
A
E
F
F
T
P
D
N
I
I
I
Y
D
H
N
E
G
K
V
Y
V
N
A
D
L
S
S
--
V
G
------------------------------
G
----
C
G
D
-
I
-------
G
-
E
F
K
V
S
F
Y
D
E
S
L
N
K
N
S
Y
E
R
I
V
S
E
S
L
E
Y
I
R
S
---
G
Y
I
F
Q
V
V
L
S
R
F
Y
R
Y
I
F
--
S
--
G
D
P
L
R
I
Y
Y
N
L
R
R
I
N
P
S
P
Y
M
F
Y
L
K
F
-
D
------
E
K
-
Y
L
I
G
S
S
P
E
--
L
L
F
R
--
V
--
Q
--
D
N
I
V
E
T
Y
P
I
A
G
T
R
P
R
G
A
D
------
Q
E
E
------
D
L
K
L
E
L
E
L
M
N
S
E
K
D
K
A
E
H
L
M
L
V
D
L
A
R
N
D
L
G
K
V
C
V
P
G
T
V
K
V
P
E
L
M
Y
V
E
K
Y
S
H
V
Q
H
I
V
S
K
V
I
G
T
L
K
K
K
Y
N
A
L
N
V
L
S
A
T
F
P
A
G
T
V
S
G
A
P
K
P
M
A
M
N
I
I
E
T
L
E
E
Y
K
R
G
P
Y
A
G
A
V
G
F
I
S
A
D
G
N
A
E
F
A
I
A
I
R
T
A
F
L
N
K
E
L
L
R
I
H
A
G
A
G
I
V
Y
D
S
N
P
E
S
E
Y
F
E
T
E
H
K
L
K
A
L
K
T
A
I
G
-----
65
Fugue
73.89
22%
-52
- C3 -
3BZM
1
MENF_ECOLI
A:
[1-429]
---
M
Q
S
L
T
T
A
L
E
N
L
L
R
H
-
L
--------------------
S
Q
E
I
P
A
T
P
G
I
R
V
I
D
I
P
F
P
L
-------------------------------------------------------------------------
K
D
A
F
D
A
L
S
W
L
-----
A
S
----
Q
Q
--
T
---
Y
-
P
Q
F
Y
-
W
Q
-
Q
R
N
-------------------------------------
G
D
E
E
A
V
V
L
G
A
I
T
R
F
T
S
L
D
Q
A
Q
R
F
L
R
Q
H
PEHAD
L
R
I
W
G
L
N
A
F
D
P
S
Q
G
N
L
L
L
P
R
L
E
W
R
R
C
G
G
K
A
T
L
R
L
T
L
F
S
-------------------
E
S
S
-
L
Q
H
D
-------
A
I
Q
A
K
E
F
I
A
T
L
V
S
I
K
P
L
P
G
L
-
H
L
T
T
T
R
E
Q
H
W
P
D
K
T
G
W
T
Q
L
I
E
L
A
T
K
T
I
A
E
---
G
E
L
D
K
V
V
L
A
R
A
T
D
L
H
F
--
A
SP
V
N
A
A
A
M
M
A
A
S
R
R
L
N
L
N
C
Y
H
F
Y
M
A
F
D
G
------
E
N
-
A
F
L
G
S
S
P
E
--
R
L
W
R
--
R
--
R
--
D
K
A
L
R
T
E
A
L
A
G
T
V
A
N
N
P
D
------
D
K
Q
------
A
Q
Q
L
G
E
W
L
M
A
D
D
K
N
Q
R
E
N
M
L
V
V
E
D
I
C
Q
R
L
Q
A
D
T
Q
T
L
D
V
L
P
P
---
Q
V
L
R
L
R
K
V
Q
H
L
R
R
C
I
W
T
S
L
N
K
A
-
D
D
V
I
C
L
H
Q
L
Q
P
T
A
A
V
A
G
L
P
R
D
L
A
R
Q
F
I
A
R
H
E
P
F
T
R
E
W
Y
A
G
S
A
G
Y
L
S
-
L
Q
Q
S
E
F
C
V
S
L
R
S
A
K
I
S
G
N
V
V
R
L
Y
A
G
A
G
I
V
R
G
S
D
P
E
Q
E
W
Q
E
I
D
N
K
A
A
G
L
R
T
L
L
Q
-----
62
Fugue
72.73
22%
-50
- C3 -
2EUA
1
MENF_ECOLI
A:
[2-429]
----------------------
Q
S
L
-
T
T
--
A
--
L
E
N
-
L
L
R
H
L
S
Q
E
I
P
A
T
P
G
I
R
V
I
D
I
P
F
P
L
----------------------------------------------------------------------
K
D
A
F
D
A
L
S
W
L
-----
A
S
----
Q
Q
--
T
---
Y
-
P
Q
F
Y
-
W
Q
-
Q
R
N
-------------------------------------
G
D
E
E
A
V
V
L
G
A
I
T
R
F
T
S
L
D
Q
A
Q
R
F
L
R
----------------
Q
H
P
E
H
A
D
L
R
I
W
G
L
N
A
F
D
P
S
Q
G
N
L
L
L
P
R
L
E
W
R
--
R
C
GG
K
A
T
L
R
L
T
L
F
-
S
E
S
S
-
L
Q
H
D
-------
A
I
Q
A
K
E
F
I
A
T
L
V
S
I
K
P
L
P
G
L
-
H
L
T
T
T
R
E
Q
H
W
P
D
K
T
G
W
T
Q
L
I
E
L
A
T
K
T
I
A
E
---
G
E
L
D
K
V
V
L
A
R
A
T
D
L
H
F
--
A
SP
V
N
A
A
A
M
M
A
A
S
R
R
L
N
L
N
C
Y
H
F
Y
M
A
F
D
G
------
E
N
-
A
F
L
G
S
S
P
E
--
R
L
W
R
--
R
--
R
--
D
K
A
L
R
T
E
A
L
A
G
T
V
A
N
N
P
D
------
D
K
Q
------
A
Q
Q
L
G
E
W
L
M
A
D
D
K
N
Q
R
E
N
M
L
V
V
E
D
I
C
Q
R
L
Q
A
D
T
Q
T
L
D
V
L
P
P
---
Q
V
L
R
L
R
K
V
Q
H
L
R
R
C
I
W
T
S
L
N
K
A
-
D
D
V
I
C
L
H
Q
L
Q
P
T
A
A
V
A
G
L
P
R
D
L
A
R
Q
F
I
A
R
H
E
P
F
T
R
E
W
Y
A
G
S
A
G
Y
L
S
-
L
Q
Q
S
E
F
C
V
S
L
R
S
A
K
I
S
G
N
V
V
R
L
Y
A
G
A
G
I
V
R
G
S
D
P
E
Q
E
W
Q
E
I
D
N
K
A
A
G
L
R
T
L
L
Q
-----
43
PsiBlast_CBE
72.16
32%
-45
- C3 -
3LOG
4
MBTI_MYCTU
B:
[178-444]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
--
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
-
G
------
G
I
-
R
A
L
G
Y
S
P
E
LV
T
A
V
R
--
A
--
D
--
G
-
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
------
P
A
I
------
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
----------
66
Fugue
71.43
21%
-65
- C3 -
3HWO
3
ENTC_ECOLI
A:
[16-394]
------
M
A
T
L
A
P
N
R
F
F
F
-
M
S
P
Y
R
S
F
-
T
T
--
S
--
G
C
F
----------------------------
A
R
F
D
E
P
A
-
V
---
N
---
G
----
D
---------------------------------------
S
---
P
D
S
P
F
Q
Q
K
L
A
A
L
-----
F
A
----
D
A
--
K
---
A
-
Q
G
I
K
-
N
P
-
V
M
V
-------------------------------------
G
A
I
P
F
-------------------
D
----------------
P
R
Q
P
S
S
L
Y
I
P
E
S
W
Q
S
F
S
R
Q
E
K
Q
A
S
A
R
R
F
T
---------------------------------------------------
R
S
Q
-
S
L
N
V
V
E
R
Q
A
I
P
E
Q
T
T
F
E
Q
M
V
A
R
A
A
A
L
T
A
T
---
P
Q
V
D
K
V
V
L
S
R
L
I
D
I
T
T
DA
A
--
I
D
S
G
V
L
L
E
R
L
I
A
Q
N
P
V
S
Y
N
F
H
V
P
L
-
A
------
D
G
G
V
L
L
G
A
S
P
E
--
L
L
L
R
--
K
--
D
--
G
E
R
F
S
S
I
P
L
A
G
S
A
R
R
Q
P
D
------
E
V
L
------
D
R
E
A
G
N
R
L
L
A
S
E
K
D
R
H
E
H
E
L
V
T
Q
A
M
K
E
V
L
R
E
R
S
S
E
L
H
V
--
P
S
S
P
Q
L
I
T
T
P
T
L
W
H
L
A
T
P
F
E
G
K
A
N
S
Q
E
N
A
L
T
L
A
C
L
L
H
P
T
P
A
L
S
G
F
P
H
Q
A
A
T
Q
V
I
A
E
L
E
P
F
D
R
E
L
F
G
G
I
V
G
W
C
D
S
E
G
N
G
E
W
V
V
T
I
R
C
A
K
L
R
E
N
Q
V
R
L
F
A
G
A
G
I
V
P
A
S
S
P
L
G
E
W
R
E
T
G
V
K
L
S
T
M
L
N
V
F
G
LH---
36
PsiBlast_CBE
70.34
32%
-47
- C3 -
2G5F
3
MBTI_MYCTU
C:
[176-442]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
IAA
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
--
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
-
G
------
G
I
-
R
A
L
G
Y
S
P
E
LV
T
A
V
R
--
A
--
D
--
G
-
V
V
I
T
E
P
L
A
G
T
R
A
L
G
R
G
------
P
A
I
------
D
R
L
A
R
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
R
G
S
V
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
----------
7
PsiBlast_PDB
69.71
40%
-67
- C3 -
4GRH
4
?
A:
[198-450]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
R
V
I
E
Y
L
R
A
---
G
D
V
F
Q
V
N
L
S
R
R
W
N
A
Q
F
--
A
AP
V
S
P
Q
A
L
Y
A
Q
L
R
R
A
N
P
A
P
F
A
G
L
F
S
A
-
H
------
G
R
-
H
V
V
S
S
S
P
E
--
R
L
V
S
--
V
--
H
--
A
G
H
A
Q
T
R
P
I
A
G
T
R
P
R
-
F
E
------
G
D
D
-------------------
E
R
A
E
H
V
M
L
I
D
L
E
R
N
D
L
G
R
I
C
L
P
G
T
V
V
V
D
E
L
M
T
V
E
S
Y
A
H
V
H
H
I
V
S
N
V
S
G
H
L
R
P
E
V
T
P
G
E
V
I
A
A
T
F
P
G
G
T
I
T
G
C
P
K
V
R
C
M
Q
I
I
S
E
L
E
Q
V
P
R
G
A
Y
T
G
A
F
G
W
L
N
R
D
G
D
L
D
L
N
I
L
I
R
T
A
E
V
D
G
H
E
V
S
F
R
T
G
A
G
I
V
V
D
S
D
P
D
K
E
L
D
E
T
R
A
K
A
R
G
L
L
---------
34
PsiBlast_CBE
68.11
32%
-49
- C3 -
3RV6
4
MBTI_MYCTU
B:
[176-442]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
--
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
-
G
------
G
I
-
R
A
L
G
Y
S
P
E
L
V
T
A
V
R
--
A
--
D
--
G
-
V
V
I
T
E
P
L
A
G
-------------------------------
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
E
----
Q
H
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
----------
12
PsiBlast_PDB
67.53
32%
-42
- C3 -
3RV6
3
MBTI_MYCTU
A:
[176-442]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
D
V
S
D
D
P
S
G
F
R
R
R
V
A
V
A
V
D
E
I
A
A
G
R
Y
H
K
V
I
L
S
R
C
V
E
V
P
F
--
A
--
I
D
F
P
L
T
Y
R
L
G
R
R
H
N
T
P
V
R
S
F
L
L
Q
L
-
G
------
G
I
-
R
A
L
G
Y
S
P
E
LV
T
A
V
R
--
A
--
D
--
G
-
V
V
I
T
E
P
L
A
G
T
R
A
------------------------
D
D
L
E
S
N
S
K
E
I
V
E
H
A
I
S
V
R
S
S
L
E
E
I
T
D
I
A
E
P
G
S
A
A
V
I
D
F
M
T
V
R
-------
L
G
S
T
I
R
A
R
L
D
P
S
S
D
R
M
A
A
L
E
A
L
F
P
A
V
T
A
S
G
I
P
K
A
A
G
V
E
A
I
F
R
L
D
E
C
P
R
G
L
Y
S
G
A
V
V
M
L
S
A
D
G
G
L
D
A
A
L
T
L
R
A
A
Y
Q
V
G
G
R
T
W
L
R
A
G
A
G
I
I
E
E
S
E
P
E
R
E
F
E
E
T
C
E
K
L
S
T
L
----------