@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1641: (2016-03-27 )
MTNWKEKARASFQLNDKTYHYYKLKTLEEDKLTNIEKLPYSVRVLLESVLRQADGRVIKDSHVEDLAHWSKDGNEGEVPFKPARVILQDFTGVPAVVDLASLRKAMADLGGDPEKINPEIPVDLVVDHSVQVDSYANPEALKINMELEFKRNMERYQFLNWAQKAFDNYRAVPPATGIVHQVNLEYLANVVIANEVADGEFVAFPDSLVGTDSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPIPEVIGVKLLGALPNGATATDFALKVTQVLREQKVVGKFVEFYGPGVATLPLADRATVANMAPEYGATCGFFPVDKEALNYLKLTGRDKEQIELVEAYLEANDLFFTPEKVEPNYTQTVEIDLSAIEPNLAGPKRPQDLIPLSKMKETFRESITAKAGNQGFGLDKSALDKEVTVTFGNGDQSTMKTGSVAIAAITSCTNTSNPYVMLSAGLVAKKAVEKGLEVPKFVKTSLAPGSKVVTGYLEKAGLLPYLEKLGFDLVGYGCTTCIGNSGPLKEEIEEAIQDSDLLVSAVLSGNRNFEGRIHALVKANFLASPPLVVAYALAGTTNVDMLTEPIGRGNNGEEVFLDDIWPSSEEVKALVEETVTPELFREQYAHVFDENEAWNAIETTEDALYKWDENSTYIANPPFFDNLAKEAGKVEALSGLRIIGKFGDSVTTDHISPAGAIGKDTPAGKFLQEQGVAIRDFNSYGSRRGHHDVMMRGTFANIRIKNQIAPGTEGGYTTYWPTGEVMSIYDASRKYIENNTGLVILAGDDYGMGSSRDWAAKGTNLLGIKTVIAKSYERIHRSNLVMMGVLPLQFQPGEDAETLGLTGSESLQVEIGEDVAPRDLVKVTATREDGSSITFDALARFDSEVEIDYYRHGGILPMVLRGKLK
Atome Classification :
(20 SA)
.........10........20......-..30........40........50........60........70.-...-.-...80........90........100.......110.......120.......130.......140.......150---........160.....--.--.170.......180.......190.......200....-..-.210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350....--.....360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550....-....560.......570.......580.......590.----......600.......610.......620.......630....-....640.......650.......660.......670.......680.......690.......700.......710.......720.......730........740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840...-....850.......860.......870.......880.......890.......900
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
N
W
K
E
K
A
R
A
S
F
Q
LND
K
T
Y
H
Y
Y
K
L
K
TL-EEDKLT
N
I
E
KL
P
Y
S
V
R
V
L
L
E
S
V
L
R
QAD
G
R
V
I
K
D
S
H
V
E
D
L
A
H
WSKD-GNE-G-EVP
F
K
P
A
R
V
I
L
Q
DFTG
V
P
A
V
V
D
L
A
S
L
R
K
A
M
A
DLGGDPEKINPEI
P
V
D
L
V
VDHSVQVDSYANP
E
A
L
K
I
N
M
E
L
E
FKR----N
M
E
R
Y
Q
F
L
N
W
A
Q
K
A
F
D--N--YRAVPPATG
I
V
H
Q
V
N
L
E
Y
L
A
N
V
V
I
A
NEVADG
E
F
V
AFP
D
-
S
L-VGTDSH
T
T
M
I
N
G
I
G
V
L
GWGVGGIEAEAGMLGQPSYFP
I
P
E
V
I
G
V
K
L
L
GALPNGAT
A
T
D
F
A
L
K
V
T
Q
V
L
R
E
Q
K
V
V
G
K
F
V
E
F
YGPGVATLPLAD
R
A
T
V
A
NMAPEYGATCGFFPV
D
K
E
A
L
N
Y
L
KLTGR
D
K
E
Q
I
E
L
V
E
A
Y
L
EANDLF--FTPE--KVEPNY
T
Q
T
V
E
I
D
L
S
AIEPNLAGPKR
P
Q
DLI
P
L
S
K
M
K
E
T
F
R
E
S
I
T
AKAGNQGFGL
D
K
S
ALD
K
E
V
T
V
T
FGNGDQSTMKTG
S
V
A
I
A
A
I
TSCTNTSN
P
Y
V
M
L
S
A
G
L
V
A
K
K
A
V
E
KGLEV
P
K
F
V
K
T
SLAPG
S
K
V
V
T
G
Y
L
E
KAG
L
L
P
Y
L
E
K
LGF
D
L
VGYG
C
T
TCIGNSGP
L
K
E
E
I
E
E
A
IQD
S
D
L
L
V
S
A
V
LSGNRNFE
G
R
I
H
A
L
-
V
K
AN-FLASPP
L
V
V
A
Y
A
LAGTTN
V
D
M
L
TEPIGRGNNG
E
E
V
F
L
D----DIWP
S
S
E
E
V
K
A
L
V
E
ETV
T
P
E
L
F
R
E
Q
Y
A
H
V
FDENEAWN-AIETT-
E
D
A
L
Y
KWDENS
T
Y
IAN
P
P
F
F
D
N
L
A
K
EAGKVEALSG
L
R
I
I
GKFGDSVTTDHISPAGAIGKDTPA
G
K
F
L
Q
EQG
V
A
I
RD
F
N
S
YGSRRGHH
D
V
M
M
RG
T
F
-
A
N
I
R
I
K
NQIAPGTEGG
Y
T
T
YWPTG
E
V
M
S
I
Y
D
A
S
R
K
Y
IENNT
G
L
V
I
L
AGDDYGMGSSRDWAAKGT
N
L
L
G
I
K
T
V
I
A
K
S
Y
E
R
I
H
RSN
L
V
M
M
GVL
P
L
QFQPGEDAETLGLTGS
E
S
L
Q
V
E
-IGEDVAPR
D
L
V
K
V
T
A
TREDGSSI
T
F
D
A
L
A
RFDSE
V
E
I
D
Y
Y
RHGGI
L
P
M
V
LRGKLK
21
PsiBlast_CBE
98.75
52%
-79
- C3 -
2B3Y
4
ACOC_HUMAN
B:
[20-888]
--------------------
F
F
N
L
N
K
L
-
E
D
S
R
Y
G
---
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
-
Q
H
K
-
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
----
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
--
N
--
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
---
D
G
Y
Y
--
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
RD
F
N
D
P
--
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
D
H
K
T
F
I
Y
D
N
-
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
----
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
-
A
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
-
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
-
I
P
E
N
L
K
P
Q
--
M
K
V
Q
V
K
L
D
T
G
K
--
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
K
2
PsiBlast_PDB
98.24
52%
-79
- C3 -
2B3Y
4
ACOC_HUMAN
A:
[20-888]
--------------------
F
F
N
L
N
K
L
-
E
D
S
R
Y
G
---
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
-
Q
H
K
-
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
----
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
--
N
--
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
---
D
G
Y
Y
--
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
RD
F
N
D
P
--
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
D
H
K
T
F
I
Y
D
N
-
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
----
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
-
A
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
-
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
-
I
P
E
N
L
K
P
Q
--
M
K
V
Q
V
K
L
D
T
G
K
--
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
K
1
PsiBlast_PDB
98.21
52%
-80
- C3 -
2B3X
3
ACOC_HUMAN
A:
[20-888]
--------------------
F
F
N
L
N
K
L
-
E
D
S
R
Y
G
---
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
-
Q
H
K
-
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
----
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
--
N
--
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
---
D
G
Y
Y
--
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
RD
F
N
D
P
--
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
D
H
K
T
F
I
Y
D
N
-
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
----
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
-
A
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
-
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
-
I
P
E
N
L
K
P
Q
--
M
K
V
Q
V
K
L
D
T
G
K
--
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
K
24
HHSearch
98.15
52%
-77
- C3 -
2B3Y
4
ACOC_HUMAN
A:
[3-888]
---
P
F
A
H
L
A
E
P
L
D
P
V
Q
P
G
K
K
F
F
N
L
N
K
L
-
E
D
---
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
-
I
-
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
----
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
--
N
--
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
-----
G
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
--
R
D
F
N
DP
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
E
-
H
H
N
D
H
K
T
F
I
Y
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
----
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
-
A
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
-
A
N
I
R
L
L
N
R
F
L
N
-
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
-
I
P
E
N
L
K
P
Q
M
K
V
Q
V
K
L
--
D
T
G
--
K
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
K
3
PsiBlast_PDB
93.60
52%
-88
- C3 -
3SNP
-
ACOC_RABIT
A:
[34-889]
-------------------------------------
R
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
K
F
L
V
K
K
E
D
I
E
N
I
L
N
W
N
V
T
-
Q
H
M
-
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
H
S
------------------
E
F
E
R
----
N
R
E
R
F
E
F
L
K
W
G
S
K
A
F
R
--
N
--
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
---
D
G
Y
Y
--
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
Q
I
R
K
Y
L
Q
A
V
G
M
F
RD
Y
S
D
P
--
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
D
H
H
N
D
H
K
T
F
I
Y
-
N
D
S
E
F
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
------------
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
----
D
I
W
P
T
R
E
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
S
W
----------
K
L
Y
L
W
N
P
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
I
M
A
R
G
T
F
-
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
S
L
G
L
T
G
R
E
R
Y
T
I
I
-
I
P
E
N
L
T
P
R
M
H
V
Q
V
K
L
D
----
T
G
K
T
F
Q
A
V
I
R
F
D
T
D
V
E
L
T
Y
F
H
N
G
G
I
L
N
Y
M
I
R
K
M
A
K
4
PsiBlast_PDB
93.10
52%
-89
- C3 -
3SN2
-
ACOC_RABIT
A:
[34-889]
-------------------------------------
R
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
K
F
L
V
K
K
E
D
I
E
N
I
L
N
W
N
V
T
-
Q
H
M
-
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
---------------------
F
E
R
----
N
R
E
R
F
E
F
L
K
W
G
S
K
A
F
R
--
N
--
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
---
D
G
Y
Y
--
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
Q
I
R
K
Y
L
Q
A
V
G
M
F
RD
Y
S
D
P
--
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
D
H
H
N
D
H
K
T
F
I
Y
-
N
D
S
E
F
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
------------
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
-
T
R
A
N
-
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
----
D
I
W
P
T
R
E
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
S
---------
S
D
K
L
Y
L
W
N
P
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
I
M
A
R
G
T
F
-
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
S
L
G
L
T
G
R
E
R
Y
T
I
I
-
I
P
E
N
L
T
P
R
M
H
V
Q
V
K
L
D
----
T
G
K
T
F
Q
A
V
I
R
F
D
T
D
V
E
L
T
Y
F
H
N
G
G
I
L
N
Y
M
I
R
K
M
A
K
11
PsiBlast_PDB
70.36
27%
-56
- C3 -
1B0J
2
ACON_PIG
A:
[46-745]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
--
V
G
F
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
P
--
G
C
--
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
8
PsiBlast_PDB
70.29
27%
-56
- C3 -
1C97
3
ACON_BOVIN
A:
[45-744]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
--
V
G
F
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
P
--
G
C
--
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
10
PsiBlast_PDB
70.11
27%
-54
- C3 -
1C96
3
ACON_BOVIN
A:
[45-744]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
--
V
G
F
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
P
--
G
C
--
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
----
A
--
P
D
A
D
E
---
L
P
R
A
E
F
D
P
G
--
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
A
V
S
P
T
-
S
Q
R
L
Q
-------------
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
14
PsiBlast_PDB
69.96
26%
-55
- C3 -
1FGH
2
ACON_BOVIN
A:
[46-745]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
--
V
G
F
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
S
--
G
C
--
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
12
PsiBlast_PDB
69.79
27%
-56
- C3 -
1B0M
2
ACON_PIG
A:
[45-744]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
--
V
G
F
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
P
--
G
C
--
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
Q
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
7
PsiBlast_PDB
69.71
27%
-56
- C3 -
7ACN
2
ACON_PIG
A:
[46-745]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
--
V
G
F
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
P
--
G
C
--
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
25
HHSearch
69.64
28%
-54
- C3 -
1C96
3
ACON_BOVIN
A:
[14-752]
-----------------
Y
I
R
Y
D
L
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
N
------
Q
E
I
----------
E
R
G
K
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
-------
G
-
L
P
K
V
A
V
P
S
---
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
---
G
--
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
---------------
Y
A
Y
P
G
V
L
L
-
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
I
-
A
N
L
A
D
E
F
K
D
--
H
L
V
---
P
D
----
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
---------------------------
K
E
G
W
-----
P
L
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
------
K
-
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
------
L
E
A
P
D
A
D
E
L
P
R
A
E
F
---------------
D
P
G
Q
D
T
Y
Q
-
H
P
P
K
D
S
S
G
Q
R
V
A
V
S
P
T
S
Q
R
L
Q
L
L
E
P
F
D
K
W
-----
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
-------------
L
I
-
G
A
I
N
I
E
N
R
K
A
-----
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
--
K
I
H
P
V
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
-
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
-
17
PsiBlast_PDB
69.50
26%
-56
- C3 -
1AMJ
3
ACON_BOVIN
A:
[46-745]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
--
V
G
F
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
S
--
G
C
--
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
13
PsiBlast_PDB
69.50
26%
-56
- C3 -
1ACO
2
ACON_BOVIN
A:
[46-745]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
--
V
G
F
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
S
--
G
C
--
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
9
PsiBlast_PDB
69.50
27%
-55
- C3 -
1B0K
3
ACON_PIG
A:
[45-744]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
--
V
G
F
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
P
--
G
C
--
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
15
PsiBlast_PDB
69.39
26%
-56
- C3 -
8ACN
2
ACON_BOVIN
A:
[46-745]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
--
V
G
F
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
S
--
G
C
--
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
19
PsiBlast_PDB
69.36
26%
-56
- C3 -
1NIT
2
ACON_BOVIN
A:
[46-745]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
V
G
F
--
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
S
--
G
C
--
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
R
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
16
PsiBlast_PDB
69.31
26%
-56
- C3 -
1AMI
2
ACON_BOVIN
A:
[46-745]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
--
V
G
F
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
S
--
G
C
--
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------
18
PsiBlast_PDB
68.99
26%
-55
- C3 -
1NIS
2
ACON_BOVIN
A:
[46-745]
--------------------------------------------------------------
H
L
D
D
P
A
N
Q
E
I
E
-
R
G
K
-
T
-
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
---------
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
G
V
G
F
--
W
R
---
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
---------------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
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L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
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L
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V
K
G
G
T
G
A
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V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
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C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
----
A
D
I
A
N
L
A
D
E
F
K
D
H
L
--
V
P
D
S
--
G
C
--
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
--------
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
--
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
-
P
E
T
H
A
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V
T
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P
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V
T
A
L
A
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A
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K
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N
P
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-
T
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G
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K
F
K
L
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A
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D
A
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A
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Q
D
T
Y
Q
H
P
P
K
D
S
S
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Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-
L
L
E
P
F
-
D
----
K
W
D
-------------------
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
------
P
W
L
K
F
-----------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
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Y
G
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G
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G
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A
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K
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A
R
I
H
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T
N
L
K
K
Q
G
L
L
P
L
T
F
--
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
-
G
L
K
D
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
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T
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L
L
N
H
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F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
---------