@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1646: (2016-03-27 )
MKFLHTADLHLGKIVSGVSMLAEQEYILTQITQIAEEEQVDALILAGDLYDRAVPPADAVKVLNDILVKWNVELGIPIFAISGNHDSAERLAFGSQWYESSKLYMKGKCTSQFDGIPFMDAEVWLVPYHEPAIIRQAFADNSIRSFEDAMQAVTKQIRSKWDTSKAQILVGHAFVSGGIPSDSERQLAIGNVDRVSTDCFDGFTYTALGHLHHPHAIRHPSIFYSGSPLKYSFSEANDHKSVRIVELEGKELISVTERFLTPKHDMRIISGTLAELTENLVENPDDFFQVNLMDEGALIDPMGKLRQFYPNILHLERKKQTLKETQDSFEEIMKKDDLELFGQFFEHVNGTELTETQKQKLADVFEQARKEDAE
Atome Classification :
(20 SA)
---.........10....----..-.----.20.....-----...30........40.......-.-50.-....----...60........70........80........90-------....--.-...100........110----......-----------.------.--120.......130--.-......------.140....-...150.......160......-------..170.....-----..180..----.....190.......200.--........210.....-..---220-........230-----------------....---------------.----..----240---........250---..--.......260........270-----.--.......280--.-.-----......290.....-..300.......310......-----.320.--.---..-.-..-330.......340.......350.......360.-......370..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MK
F
L
H
TAD
L
H
L
G
K
I
V
----
S
G
-
V
----
S
M
L
A
E
Q
E
Y
-----
I
L
T
Q
I
T
Q
I
A
E
E
EQV
D
A
L
I
L
AG
D
-
L
-YDR-AVP
P
----
A
D
A
V
K
V
L
N
D
I
L
V
K
W
N
V
E
LG
I
P
I
F
A
I
SGNHD
S
A
E
R
L
-------
A
FG
S
--
Q
-WYESS-
K
L
Y
M
KGKCTS-----QFDGIP-----------F------M--DA
E
V
W
L
V
PYH
E
P
---
A
-
I
I
R
Q
A
F------ADN
S
I
R
S
F
-
E
D
A
M
Q
A
V
T
K
Q
I
R
S
KW-DTSK
A
Q
-------
I
L
V
G
H
A
F
VSG-----GIPSDSE----R
Q
L
AIGNVDRVSTDCF--D--G
F
T
Y
T
A
LGHLHHPHAI-RH---P
S
--
I
F
YSGSP
L
K
Y
S-----------------FSEA---------------N----DH----
K
S
----
V
R
I
V
E
LE
G
K
-----
E
L
--
I
S
V
T
E
R
FLT-PKH
D
M
R
I
I
S
G
------
T
--
L
A
E
L
T
E
N
L
V---E-N-----PD
D
F
F
Q
V
N
LMDEGA-LID
P
M
G
K
L
R
Q
F
Y
P
N
I
L
H
L
E
R
K
-----
K
Q
T
L
K
--
E
---
T
Q
-
D
-
S
F
-
E
E
I
M
K
K
D
D
L
E
L
F
G
Q
F
F
E
HVNGTEL
T
E
T
Q
K
Q
K
L
A
D
-
V
F
E
Q
A
R
KEDAE-
21
HHSearch
82.70
23%
-85
* C1 *
3THO
6
RAD50_THEMA
B:
[1-377]
---
M
K
I
L
H
T
S
D
W
H
L
G
V
T
S
----
W
T
-
S
SRPV
D
R
R
E
E
L
K
K
-----
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
-
L
-
L
H
S
R
N
N
P
S
----
V
V
A
L
H
D
L
L
D
Y
L
K
R
M
M
R
--
T
A
P
V
V
V
L
P
G
N
Q
D
W
K
G
L
K
-------
L
F
G
N
--
F
V
T
S
I
S
S
-
D
I
T
F
V
M
S
F
E
-------
P
V
D
V
E
-----------
A
KRG---
Q
--
K
V
R
I
L
P
F
P
Y
P
D
E
---
S
-----
K
N
------
E
G
D
F
R
F
F
L
-
E
S
R
L
N
K
L
Y
E
---
E
A
L
-
K
K
E
D
F
A
-------
I
F
M
G
H
F
T
V
E
G
-----
L
A
G
--------------
R
E
I
I
I
N
R
A
L
I
--
P
S-
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
-
Q
K
Q--
P
L
--
T
I
Y
P
G
S
L
I
R
I
D
-----------------
F
G
E
E
---------------
A
----
D
E
----
K
G
----
A
V
F
V
E
L
K
R
G
E----
P
P
---
R
Y
E
R
I
D
A
S
-
P
L
-
P
L
K
T
L
Y
Y
KKID
T
S
A
--
L
K
S
I
R
D
S
C
R
---
N
-------
F
P
G
Y
V
R
V
V
Y
E
E
D
S
G
I
L
P
D
L
M
G
E
I
----
D
N
L
V
K
I
E
R
K
-----
S
R
R
E
I
E
E
V
L--
R
E
S
P
E
E
F
K
E
E
L
D
K
L
D
Y
F
E
L
F
K
E
Y
L
K
K
R
--
E
E
N
H
E
K
L
L
K
I
L
D
E
-
L
L
D
E
V
K
K
S
----
5
PsiBlast_PDB
81.27
25%
-71
- C1 -
3QG5
1
?
C:
[2-379]
----
K
I
L
H
T
S
D
W
H
L
G
V
T
S
WTSS
R
P
-
V
----
D
R
R
E
E
L
K
K
-----
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
-
L
L
H
S
R
-
N
N
P
S
----
V
V
A
L
H
D
L
L
D
Y
L
K
R
--
M
M
R
T
A
P
V
V
V
L
P
G
N
H
D
W
K
G
L
K
-------
L
F
G
N
--
F
-
V
T
S
I
S
-
S
D
I
T
F
V
M
S
F
E
-----
P
V
D
V
E
A
-----------
K
------
R
--
G
Q
K
V
R
I
L
P
F
P
Y
P
DE-------
N
E
------
G
D
--
F
R
F
F
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
E
-
D
F
A
----------
I
F
M
G
H
F
T
V
E
-----------
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
---------------
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
Q
---
P
L
--
T
I
Y
P
G
S
L
I
R
I
D
-----------------
F
G
E
E
---------------
A
----
D
E
----
K
G
----
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
--
I
D
A
S
P
L
P
L
K
-
T
L
Y
Y
K
K
I
D
T
S
------
A
--
L
K
S
I
R
D
F
C
R
---
N
-
F
-----
P
G
Y
V
R
V
V
Y
E
E
D
S
G
I
-
L
P
D
L
M
G
E
I
----
D
N
L
V
K
I
E
R
K
S
R
REI
E
E
V
L
R
--
E
---
S
P
-
E
-
E
F
-
K
E
E
L
--
D
K
L
D
Y
F
E
L
F
K
E
Y
L
K
K
R
E
E
N
H
E
K
L
L
K
I
L
D
E
L
L
D
E
V
K
K
S
E
A
--
4
PsiBlast_PDB
79.18
26%
-68
- C1 -
3THO
6
RAD50_THEMA
B:
[1-377]
---
M
K
I
L
H
T
S
D
W
H
L
G
V
T
S
WTSS
R
P
-
V
----
D
R
R
E
E
L
K
K
-----
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
-
L
L
H
S
R
-
N
N
P
S
----
V
V
A
L
H
D
L
L
D
Y
L
K
R
--
M
M
R
T
A
P
V
V
V
L
P
G
N
Q
D
W
K
G
L
K
-------
L
F
G
N
--
F
-
V
T
S
I
S
-
S
D
I
T
F
V
M
S
F
E
-----
P
V
D
V
E
A
-----------
K
------
R
--
G
Q
K
V
R
I
L
P
F
P
Y
P
DES-----
K
N
E
------
G
D
--
F
R
F
F
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
E
-
D
F
A
----------
I
F
M
G
H
F
T
V
E
G
LAG-------
R
E
IIIN
R
A
L
I
P
S
V
V
D
---------------
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
Q
---
P
L
--
T
I
Y
P
G
S
L
I
R
I
D
-----------------
F
G
E
E
---------------
A
----
D
E
----
K
G
----
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
--
I
D
A
S
P
L
P
L
K
-
T
L
Y
Y
K
K
I
D
T
S
------
A
--
L
K
S
I
R
D
S
C
R
---
N
-
F
-----
P
G
Y
V
R
V
V
Y
E
E
D
S
G
I
-
L
P
D
L
M
G
E
I
----
D
N
L
V
K
I
E
R
K
SR
R
E
I
E
E
V
L
R
--
E
---
S
P
-
E
-
E
F
-
K
E
E
L
--
D
K
L
D
Y
F
E
L
F
K
E
Y
L
K
K
R
E
E
N
H
E
K
L
L
K
I
L
D
E
L
L
D
E
V
K
K
S
----
2
PsiBlast_PDB
76.55
29%
-82
- C1 -
4M0V
3
?
A:
[15-312]
---
M
R
I
L
H
T
S
D
W
H
L
G
Q
N
F
----
Y
S
-
K
----
S
R
E
A
E
H
Q
A
-----
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
-
V
-
F
D
T
-
G
S
P
P
----
S
Y
A
R
T
L
Y
N
R
F
V
V
N
L
Q
-
Q
T
G
C
H
L
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
S
R
D
I
M
A
F
L
N
--
T
-
T
V
V
A
S
-
A
G
H
A
P
-
Q
I
L
P
-----
R
R
D
G
T
P
---------------------
G
A
V
L
C
P
I
P
F
L
R
P
---
R
D
I
I
T
S
Q
------------
E
K
Q
-
Q
H
L
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
K
L
R
GDQP
L
P
I
I
A
T
G
H
L
T
T
V
G
-----
A
S
K
S
D
A
V
----
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
--
P
--
P
A
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
M
---
E
H
--
V
R
Y
C
G
S
P
I
P
L
S
-----------------
F
D
E
C
---------------
G
----
K
S
----
K
Y
----
V
H
L
V
T
F
S
N
G
-----
K
L
--
E
S
V
E
N
L
N
V
P
-
V
T
Q
P
M
A
V
L
K
G
------
D
--
L
A
S
I
T
A
Q
L
-----------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.13
29%
-78
- C1 -
4LU9
2
?
C:
[15-313]
---
M
R
I
L
H
T
S
D
W
H
L
G
Q
N
F
----
Y
S
-
K
----
S
R
E
A
E
H
Q
A
-----
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
-
V
-
F
D
T
-
G
S
P
P
----
S
Y
A
R
T
L
Y
N
R
F
V
V
N
L
Q
-
Q
T
G
C
H
L
V
V
L
A
G
N
H
D
S
V
A
T
L
N
ES
R
D
I
M
A
F
L
N
--
T
-
T
V
V
A
S
-
A
G
H
A
P
-
Q
I
L
P
-----
R
R
D
G
T
P
---------------------
G
A
V
L
C
P
I
P
F
L
R
P
---
R
D
I
I
T
S
Q
A
------
G
L
N
G
I
E
K
Q
-
Q
H
L
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
K
L
R
GDQP
L
P
I
I
A
T
G
H
L
T
T
V
G
-----
A
S
K
S
D
A
V
----
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
--
P
--
P
A
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
M
---
E
H
--
V
R
Y
C
G
S
P
I
P
L
S
-----------------
F
D
E
C
---------------
G
----
K
S
----
K
Y
----
V
H
L
V
T
F
S
N
G
-----
K
L
--
E
S
V
E
N
L
N
V
P
-
V
T
Q
P
M
A
V
L
K
G
------
D
--
L
A
S
I
T
A
Q
L
-----------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.86
29%
-81
- C1 -
4LTY
1
?
C:
[15-314]
---
M
R
I
L
H
T
S
D
W
H
L
G
Q
N
F
----
Y
S
-
K
----
S
R
E
A
E
H
Q
A
-----
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
-
V
-
F
D
T
-
G
S
P
P
----
S
Y
A
R
T
L
Y
N
R
F
V
V
N
L
Q
-
Q
T
G
C
H
L
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
S
R
D
I
M
A
F
L
N
--
T
-
T
V
V
A
S
-
A
G
H
A
P
-
Q
I
L
P
-----
R
R
D
G
T
P
---------------------
G
A
V
L
C
P
I
P
F
L
R
P
---
R
D
I
I
T
S
Q
------------
E
K
Q
-
Q
H
L
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
K
L
R
GDQP
L
P
I
I
A
T
G
H
L
T
T
V
G
-----
A
S
K
S
D
A
V
----
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
--
P
--
P
A
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
M
---
E
H
--
V
R
Y
C
G
S
P
I
P
L
S
-----------------
F
D
E
C
---------------
G
----
K
S
----
K
Y
----
V
H
L
V
T
F
S
N
G
-----
K
L
--
E
S
V
E
N
L
N
V
P
-
V
T
Q
P
M
A
V
L
K
G
------
D
--
L
A
S
I
T
A
Q
L
-----------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.88
26%
-71
- C1 -
3THN
5
?
A:
[1-319]
---
M
K
I
L
H
T
S
D
W
H
L
G
V
T
S
WTS
S
R
P
-
V
----
D
R
R
E
E
L
K
K
-----
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
-
H
S
R
-
N
N
P
S
----
V
V
A
L
H
D
L
L
D
Y
L
K
R
--
M
M
R
T
A
P
V
V
V
L
P
G
N
Q
D
W
K
G
L
K
-------
L
F
G
N
--
F
-
V
T
S
I
S
-
S
D
I
T
F
V
M
S
F
E
-----
P
V
D
V
E
A
-----------
K
------
R
--
G
Q
K
V
R
I
L
P
F
P
Y
P
D
E
S
E
-
A
L
R
K
N
E
------
G
D
--
F
R
F
F
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
E
-
D
F
A
----------
I
F
M
G
H
F
T
V
E
G
LAGYA----
G
R
E
IIIN
R
A
L
I
P
S
V
V
D
---------------
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
Q
---
P
L
--
T
I
Y
P
G
S
L
I
R
I
D
-----------------
F
G
E
E
---------------
A
----
D
E
----
K
G
----
A
V
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
--
I
D
A
S
P
L
P
L
K
-
T
L
Y
Y
K
K
I
D
T
S
------
A
--
L
K
S
I
R
D
S
C
R
---
N
-
F
-----
P
G
Y
V
R
V
V
Y
E
E
D
S
---
L
P
D
L
M
G
E
I
D
----
N
L
V
K
I
E
R
------------------------------------------------------------------------
11
PsiBlast_PDB
73.50
27%
-84
- C1 -
4NZV
2
?
A:
[19-270]
---
L
K
I
L
H
T
S
D
W
H
L
G
V
T
S
WTSS
R
P
-
V
----
D
R
R
E
E
L
K
K
-----
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
-
H
S
R
-
N
N
P
S
----
V
V
A
L
H
D
L
L
D
Y
L
K
R
--
M
M
R
T
A
P
V
V
V
L
P
G
N
H
D
W
K
G
L
K
-------
L
F
G
N
--
F
-
V
T
S
I
S
-
S
D
I
T
F
V
M
S
F
E
-----
P
V
D
V
E
A
-----------
K
------
R
--
G
Q
K
V
R
I
L
P
F
P
Y
P
DES
E
-
A
L
R
K
N
E
------
G
D
--
F
R
F
F
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
E
-
D
F
A
----------
I
F
M
G
H
F
T
V
E
G
LAGYA
G
I
E
Q
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
---------------
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
Q
---
P
L
--
T
I
Y
P
G
S
L
I
R
I
D
-----------------
F
G
E
E
---------------
A
----
D
E
----
K
G
----
A
V
F
V
E
L
K
R
G
-----
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.27
27%
-83
- C1 -
4O5G
3
?
A:
[19-270]
---
L
K
I
L
H
T
S
D
W
H
L
G
V
T
S
WTSS
R
P
-
V
----
D
R
R
E
E
L
K
K
-----
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
-
H
S
R
-
N
N
P
S
----
V
V
A
L
H
D
L
L
D
Y
L
K
R
--
M
M
R
T
A
P
V
V
V
L
P
G
N
H
D
W
K
G
L
K
-------
L
F
G
N
--
F
-
V
T
S
I
S
-
S
D
I
T
F
V
M
S
F
E
-----
P
V
D
V
E
A
-----------
K
------
R
--
G
Q
K
V
R
I
L
P
F
P
Y
P
D
E
S
E
-
A
L
R
K
N
E
------
G
D
--
F
R
F
F
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
E
-
D
F
A
----------
I
F
M
G
H
F
T
V
E
G
LAGYA
G
I
E
Q
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
---------------
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
Q
---
P
L
--
T
I
Y
P
G
S
L
I
R
I
D
-----------------
F
G
E
E
---------------
A
----
D
E
----
K
G
----
A
V
F
V
E
L
K
R
G
-----
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.21
27%
-84
- C1 -
4O4K
3
?
A:
[19-270]
---
L
K
I
L
H
T
S
D
W
H
L
G
V
T
S
WTSS
R
P
-
V
----
D
R
R
E
E
L
K
K
-----
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
-
H
S
R
-
N
N
P
S
----
V
V
A
L
H
D
L
L
D
Y
L
K
R
--
M
M
R
T
A
P
V
V
V
L
P
G
N
H
D
W
K
G
L
K
-------
L
F
G
N
--
F
-
V
T
S
I
S
-
S
D
I
T
F
V
M
S
F
E
-----
P
V
D
V
E
A
-----------
K
------
R
--
G
Q
K
V
R
I
L
P
F
P
Y
P
DES
E
-
A
L
R
K
N
E
------
G
D
--
F
R
F
F
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
E
-
D
F
A
----------
I
F
M
G
H
F
T
V
E
G
LAGYA
G
I
E
Q
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
---------------
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
Q
---
P
L
--
T
I
Y
P
G
S
L
I
R
I
D
-----------------
F
G
E
E
---------------
A
----
D
E
----
K
G
----
A
V
F
V
E
L
K
R
G
-----
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
71.34
22%
-79
- C1 -
1II7
6
MRE11_PYRFU
A:
[1-322]
---
M
K
F
A
H
L
A
D
I
H
L
G
Y
E
Q
----
F
H
K
P
----
Q
R
E
E
E
F
A
E
-----
A
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
-
L
-
F
H
S
-
S
R
P
S
----
P
G
T
L
K
K
A
I
A
L
L
Q
I
P
K
E
-
H
S
I
P
V
F
A
I
E
G
N
H
D
R
T
Q
R
G
-------
P
S
V
L
--
N
-
L
L
E
D
F
G
L
V
Y
V
I
G
M
R
K
E
K
V
E
N
E
Y
L
T
S
E
R
L
GNG
E
Y
L
V
K
G
V
Y
------
K
--
D
L
E
I
H
G
M
K
Y
M
S
S
---
A
-
W
F
-----------------------
E
A
N
K
E
I
L
K
R
L
F
-
R
P
T
D
N
A
-------
I
L
M
L
H
Q
G
V
R
E
-----
V
S
E
A
R
G
E
----
D
------
Y
F
E
I
G
L
G
D
L
P-
E
--
G
Y
L
Y
Y
A
L
G
H
I
H
K
R
Y
E
T
-
S
Y
SG-
S
P
--
V
V
Y
P
G
S
L
E
R
W
D
-----------------
F
G
D
Y
E
V
R
Y
E
W
DGI
K
F
K
E
R
Y
G
----
V
N
----
K
G
----
F
Y
I
V
E
D
F
------------
K
P
R
F
V
E
I
K
-
V
R
-
P
F
I
D
V
K
I
------
K
G
S
E
E
E
I
R
K
A
I
K
R
L
I
P
L
I
P----
K
N
A
Y
V
R
L
N
I
G
W
R
K
P
---
F
D
L
T
E
I
K
E
L
L
N
-------------------------------------------------------------------------------
12
PsiBlast_PDB
70.74
27%
-81
- C1 -
4O43
4
?
A:
[19-270]
---
L
K
I
L
H
T
S
D
W
H
L
G
V
T
S
WTSS
R
P
-
V
----
D
R
R
E
E
L
K
K
-----
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
-
H
S
R
-
N
N
P
S
----
V
V
A
L
H
D
L
L
D
Y
L
K
R
--
M
M
R
T
A
P
V
V
V
L
P
G
N
H
D
W
K
G
L
K
-------
L
F
G
N
--
F
-
V
T
S
I
S
-
S
D
I
T
F
V
M
S
F
E
-----
P
V
D
V
E
A
-----------
K
------
R
--
G
Q
K
V
R
I
L
P
F
P
Y
P
DES
E
-
A
L
R
K
N
E
------
G
D
--
F
R
F
F
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
E
-
D
F
A
----------
I
F
M
G
H
F
T
V
E
G
LAGYA
G
I
E
Q
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
---------------
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
Q
---
P
L
--
T
I
Y
P
G
S
L
I
R
I
D
-----------------
F
G
E
E
---------------
A
----
D
E
----
K
G
----
A
V
F
V
E
L
K
R
G
-----
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.70
27%
-82
- C1 -
4O24
4
?
A:
[18-269]
---
L
K
I
L
H
T
S
D
W
H
L
G
V
T
S
WTSS
R
P
-
V
----
D
R
R
E
E
L
K
K
-----
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
-
H
S
R
-
N
N
P
S
----
V
V
A
L
H
D
L
L
D
Y
L
K
R
--
M
M
R
T
A
P
V
V
V
L
P
G
N
H
D
W
K
G
L
K
-------
L
F
G
N
--
F
-
V
T
S
I
S
-
S
D
I
T
F
V
M
S
F
E
-----
P
V
D
V
E
A
-----------
K
------
R
--
G
Q
K
V
R
I
L
P
F
P
Y
P
DES
E
-
A
L
R
K
N
E
------
G
D
--
F
R
F
F
L
E
S
R
L
N
K
L
Y
E
E
A
L
K
K
E
-
D
F
A
----------
I
F
M
G
H
F
T
V
E
G
LAGYA
G
I
E
Q
G
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
---------------
Y
A
A
L
G
H
I
H
S
F
R
E
I
Q
K
Q
---
P
L
--
T
I
Y
P
G
S
L
I
R
I
D
-----------------
F
G
E
E
---------------
A
----
D
E
----
K
G
----
A
V
F
V
E
L
K
R
G
-----
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
66.37
18%
-68
- C1 -
3AV0
4
MRE11_METJA
A:
[18-386]
G
S
H
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
----
Y
N
-
L
----
D
D
R
E
K
D
I
Y
D
----
S
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
-
L
-
F
N
D
-
L
R
P
P
----
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
E
N
-
N
I
K
V
Y
I
V
A
G
N
H
E
M
P
R
R
L
-------
G
--------
E
E
S
P
-
L
A
L
L
K
D
Y
V
K
I
----------------------
L
------
D
--
G
K
D
V
I
N
V
N
G
E
E
I
---
F
-
I
C
G
T
Y
Y
------
H
K
---
K
S
K
-
R
E
E
M
L
D
K
L
K
N
F
E
S
E
A
-
K
N
Y
K
K
K
-------
I
L
M
L
H
----
Q
-----
G
I
N
P
Y
I
P
----
L
D
Y
E
L
E
H
F
D
L
--------
P
--
K
F
S
Y
Y
A
L
G
H
I
H
K
R
I
L
E
-
R
F
ND-
G
I
--
L
A
Y
S
G
S
T
E
I
I
Y
-----------------
R
N
E
Y
---------------
E
----
D
Y
----
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
-----
D
L
--
D
I
S
D
I
E
K
I
D
I
E
C
R
E
F
V
E
V
N
I
------
K
--
D
K
K
S
F
N
E
A
V
---
N
-
K
I
ERCK
N
K
P
V
V
F
G
K
I
K
R
E
F
K
-
P
W
F
D
T
L
K
D
K
I
L
I
N
K
A
I
I
V
D
D
E
-----
F
I
D
M
P
--
D
NVD
I
E
-
S
-
L
N
-
I
K
E
L
L
V
D
Y
A
N
R
Q
G
I
D
G
D
L
V
L
S
L
Y
K
A
L
L
N
N
E
N
W
K
E
-
L
L
D
E
Y
Y
N
T
K
F
R
G
23
HHSearch
65.53
22%
-91
- C1 -
3AV0
4
MRE11_METJA
A:
[21-274]
---
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
----
Y
N
L
D
----
D
R
E
K
D
I
Y
D
-----
S
F
K
L
C
I
K
K
I
L
E
I
K
P
D
V
V
L
H
S
G
D
-
L
-
F
N
D
-
L
R
P
P
----
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
E
-
N
N
I
K
V
Y
I
V
A
G
N
H
E
M
P
R
R
L
-------
G
E
E
S
P
L
A
-
L
L
-
K
D
-
Y
V
K
I
L
D
G
K
---------
D
V
I
N
-----------
V
------
N
G
E
E
I
F
I
C
G
T
Y
Y
H
K
K
---
S
-
K
R
-------------------
E
E
M
L
D
K
L
K
N
F
E
S
E
-
A
-
K
N
Y
K
K
K
-------
I
L
M
L
H
Q
G
I
N
P
-----
Y
I
P
L
D
--------------
Y
E
L
E
H
F
D
L
--
P
--
K
F
S
Y
Y
A
L
G
H
I
H
K
R
I
L
E
-
R
F
ND-
G
I
--
L
A
Y
S
G
S
T
E
I
I
Y
-----------------
R
N
E
Y
---------------
E
D
Y
K
K
E
G
----
K
G
----
F
Y
L
V
D
F
S
G
N
-----
D
L
DI
S
D
I
E
K
I
D
I
E
-
C
R
-
E
F
V
E
V
N
I
----------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
64.34
25%
-90
- C1 -
3AV0
4
MRE11_METJA
A:
[21-254]
---
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
----
Y
N
-
L
----
D
D
R
E
K
D
I
Y
D
S
F
K
L
C
I
K
K
I
L
E
I
----
K
P
D
V
V
L
H
S
G
D
-
L
-
F
N
D
-
L
R
P
P
----
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
-
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
M
P
R
R
L
-------
G
---------
E
E
S
-
P
L
A
L
L
K
D
Y
V
K
-----
I
L
D
G
------------------------
K
D
V
I
N
V
N
G
E
E
I
---
F
-
I
C
G
T
Y
Y
------
H
K
K
S
K
R
----
E
E
M
L
D
K
L
K
N
F
E
S
E
A
-
K
N
Y
K
K
K
-------
I
L
M
L
H
Q
G
I
N
P
-----
Y
I
P
L
D
Y
E
----------------
L
E
H
F
--
D
LP
K
F
S
Y
Y
A
L
G
H
I
H
K
R
I
L
E
-
R
F
---
N
D
G
I
L
A
Y
S
G
S
T
E
I
I
Y
-----------------
R
N
E
Y
---------------
E
----
D
Y
K
K
E
G
K
G
----
F
Y
L
V
D
F
S
G
N
-----
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.33
25%
-89
- C1 -
4TUI
-
MRE11_METJA
C:
[5-238]
---
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
----
Y
N
-
L
----
D
D
R
E
K
D
I
Y
D
S
F
K
L
C
I
K
K
I
L
E
I
----
K
P
D
V
V
L
H
S
G
D
-
L
-
F
N
D
-
L
R
P
P
----
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
-
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
M
P
R
R
L
-------
G
---------
E
E
S
-
P
L
A
L
L
K
D
Y
V
K
-----
I
L
D
G
------------------------
K
D
V
I
N
V
N
G
E
E
I
---
F
-
I
C
G
T
Y
Y
------
H
K
K
S
K
R
----
E
E
M
L
D
K
L
K
N
F
E
S
E
A
-
K
N
Y
K
K
K
-------
I
L
M
L
H
Q
G
I
N
P
-----
Y
I
P
L
D
Y
E
----------------
L
E
H
F
--
D
LP
K
F
S
Y
Y
A
L
G
H
I
H
K
R
I
L
E
-
R
F
---
N
D
G
I
L
A
Y
S
G
S
T
E
I
I
Y
-----------------
R
N
E
Y
---------------
E
----
D
Y
----
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
-----
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.08
25%
-91
- C1 -
4TUG
2
MRE11_METJA
C:
[5-238]
---
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
----
Y
N
-
L
----
D
D
R
E
K
D
I
Y
D
S
F
K
L
C
I
K
K
I
L
E
I
----
K
P
D
V
V
L
H
S
G
D
-
L
-
F
N
D
-
L
R
P
P
----
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
-
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
M
P
R
R
L
-------
G
---------
E
E
S
-
P
L
A
L
L
K
D
Y
V
K
-----
I
L
D
G
------------------------
K
D
V
I
N
V
N
G
E
E
I
---
F
-
I
C
G
T
Y
Y
------
H
K
K
S
K
R
----
E
E
M
L
D
K
L
K
N
F
E
S
E
A
-
K
N
Y
K
K
K
-------
I
L
M
L
H
Q
G
I
N
P
-----
Y
I
P
L
D
Y
E
----------------
L
E
H
F
--
D
LP
K
F
S
Y
Y
A
L
G
H
I
H
K
R
I
L
E
-
R
F
---
N
D
G
I
L
A
Y
S
G
S
T
E
I
I
Y
-----------------
R
N
E
Y
---------------
E
----
D
Y
----
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
-----
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
59.04
25%
-83
- C1 -
3AUZ
3
MRE11_METJA
A:
[21-254]
---
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
----
Y
N
-
L
----
D
D
R
E
K
D
I
Y
D
S
F
K
L
C
I
K
K
I
L
E
I
----
K
P
D
V
V
L
H
S
G
D
-
L
-
F
N
D
-
L
R
P
P
----
V
K
A
L
R
I
A
M
Q
A
F
K
K
L
H
-
E
N
N
I
K
V
Y
I
V
A
G
N
H
E
M
P
R
R
L
-------
G
---------
E
E
S
-
P
L
A
L
L
K
D
Y
V
K
-----
I
L
D
G
------------------------
K
D
V
I
N
V
N
G
E
E
I
---
F
-
I
C
G
T
Y
Y
------
H
K
K
S
K
R
----
E
E
M
L
D
K
L
K
N
F
E
S
E
A
-
K
N
Y
K
K
K
-------
I
L
M
L
H
Q
G
I
N
P
-----
Y
I
P
L
D
Y
E
----------------
L
E
H
F
--
D
L
P
K
F
S
Y
Y
A
L
G
H
I
H
K
R
I
L
E
-
R
F
---
N
D
G
I
L
A
Y
S
G
S
T
E
I
I
Y
-----------------
R
N
E
Y
---------------
E
----
D
Y
K
K
E
G
K
G
----
F
Y
L
V
D
F
S
G
N
-----
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
58.74
15%
-80
- C1 -
1UTE
4
PPA5_PIG
A:
[7-292]
---
L
R
F
V
A
V
G
D
W
G
G
V
P
N
A
----
P
F
-------
H
T
A
R
E
M
A
-----
N
A
K
A
I
A
T
T
V
K
T
L
G
A
D
F
I
L
S
L
G
D
-
N
-
F
Y
F
-
T
G
V
H
DAKD
K
R
F
Q
E
T
F
E
D
V
F
S
D
P
S
L
-
R
N
V
P
W
H
V
L
A
G
N
H
D
H
L
G
N
V
-------
S
A
Q
I
--
A
-
Y
S
K
I
S
-
K
R
W
N
F
P
S
--------
P
Y
Y
R
L
R
-----------
F
K
IPRSN
V
--
S
V
A
I
F
M
L
D
T
V
T
L
---
C
-
G
N
S
D
D
F
VSQQPE
R
P
R
N
L
A
L
A
-
R
T
Q
L
A
W
I
K
K
Q
L
A
A
---
A
K
E
D
Y
V
-------
L
V
A
G
H
Y
P
V
W
S
-----
I
A
E
H
G
P
T
----
H
C
--
L
--
V
K
Q
L
-
L
P
L
L
T
T
H
--
K
V
T
A
Y
L
C
G
H
D
H
N
L
Q
Y
L
-
Q
D
ENG
L
G
--
F
V
L
S
G
A
G
N
F
M
D
PSKKHLRKVPNGYLRFH
F
G
A
E
---------------
N
----
S
L
----
G
G
----
F
A
Y
V
E
I
T
P
K
-----
E
M
---
S
V
T
Y
I
E
A
S
-
G
-------------------------------------------------------------------------------------------------------------------------------------------------