@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1652: (2016-03-27 )
LKIYKALGWFFKENWKSYAFGVTILFTIALLQLVPPQIIGYTVDAVTNDSLTKDKLIKWMIILVVAAILAYGGRYVWRMLIFGSDNKLQRTLRLRLFEHFTKMSPFFFQRYRTGDLMAHATNDITAIQQVAGIGVLTLSDSVLTGGTVIATMAITIDWRLTLIALLPMPFMVLGSSILGKKLHDRFHGAQAAFSMLNDKTQESISGIKVTRTFGQEKEDIQDFAKQTKEVVQKNISVAKVDAMFDPMISIIVGVSFVLSLGFGAKFVVDGELTIGQVIAFSNYLFLLIWPMLAFGFLYNIIQRGNASYDRVQHLLAEKEDVLDQEGALDTVPVGDLQVTMDKFTYPDESEPVLADIHFNLKAGETLGIVGRTGSGKTSLLKLLMREYDTYEGKIAFANVKIQDYTVRALREAIGYVPQDQFLFSTTVRDNIRFGKPDAPQEEVTKIAKLVSVDEDILGFENGYDTIVGERGVSLSGGQKQRLAIARALIMNPELLILDDALSAVDAKTEEQILANLKENRSDKTTIISAHRLSSVEHANLIIVIDKGRIVERGTHMELMALDGWYAEMFREQQLEEALEEGGVADGSDE
Atome Classification :
(66 SA)
-----------------------------------------------------------------------------------------.........10........20.......----.30.........40.....-...-50-.-.-......60.-----.......70.-.......80........90.------...--....100.......110.......120.......--130.......140.-.-..--...150.....--....160.......170.......180.......190.......200.......210.......220.......230.......240.......250...---....260-....--...270.......280.......290.....---..300.......310.......--320.....----.--.330.-.......340....-..-.-350-........360.......370.......380.......390-..--.......400.......410.......420.......430..-..-.---.-.-440-.........450.......460.......470.......480.......490.......500.......---510.-...---...520.........530.......540.......550.......560--........570.......580-........--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------L
K
I
Y
K
A
L
G
W
F
F
K
E
NW
K
S
Y
A
F
G
V
T
I
L
F
T
I
----
A
L
-
L
Q
LVPPQ
I
I
G
Y
T
V
DAV-TND-SL-
T
-
K
-
D
K
L
I
K
W
M
I
I
-----
L
V
V
A
A
I
L
A
YG-G
R
Y
V
W
R
M
L
I
FGSD
N
K
L
Q
R
T
L
------
R
L
R
--
L
F
E
H
F
T
KM
S
P
F
F
F
Q
RYRTGD
L
M
AHAT
N
D
I
T
A
I
Q
Q
--
V
AG
I
G
V
L
T
LSDSVL-T-G
G
--
T
V
I
A
--
T
M
A
I
T
--
I
D
W
R
L
T
L
I
A
LLP
M
P
F
M
V
L
G
S
S
I
L
G
K
K
L
H
D
R
F
H
G
A
Q
A
A
F
S
M
LN
D
K
T
Q
E
SIS
G
I
K
V
T
RTFGQ
E
K
E
D
I
Q
D
F
A
K
Q
T
K
E
V
V
Q
KNISV
A
K
V
D
A
M
F
D
P
M
I
S
I
I
V
G
V
S
---
F
V
L
S
LGF-G
A
K
F
--
V
VDGE
L
T
I
G
Q
V
I
A
F
SN
Y
L
F
L
L
I
W
P
M
L
A
F
G
F
L
---
Y
N
I
I
QRGNA
S
Y
D
R
V
Q
H
L
L
A
E
K
E
--
D
VLDQEGA----L--DT-VP-VG
D
L
Q
V
T
M
DKFTYP-DE-S-E-
P
-
V
L
A
D
I
H
F
N
LKAG
E
T
L
G
I
VGRTGS
G
K
T
S
L
L
K
L
L
M
R
EYDTY---E
G
--
K
I
A
F
A
N
V
K
I
Q
D
Y
T
V
R
A
L
R
E
A
IGYVPQD
Q
F
L
F
S
T
TVRDNIRFG-KP-D---A-
P
-
Q
---
E
E
V
T
K
I
A
K
L
V
SV
D
E
D
I
LGFENGY
D
T
IVGERGVSLSGG
Q
K
Q
R
L
A
I
A
R
A
L
IMNP
E
L
L
I
LD
D
A
L
S
AVDA
K
T
E
---
E
Q
I
L
-
A
N
L
---
K
ENR--SDK
T
T
I
I
S
A
HRLSSVEHA
N
L
I
I
V
IDKG
R
I
VERGT
H
M
E
L
M
A-L--D
G
W
Y
A
E
M
F
R
E
Q
Q
L
E
E
A
L
E
EG--GVADGSDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
88.01
32%
-97
- C1 -
2HYD
3
Y1866_STAAM
B:
[8-578]
---------------------------------------------------------------------------------------------------
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
----
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
-
I
N
N
H
A
L
-
T
-
T
-
D
E
K
V
H
H
L
T
I
AIGIA
L
F
I
F
V
I
V
R
P
P
-
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
------
R
K
K
--
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
--
F
I
L
T
G
L
M
N
I
W
---
L
-
D
-
C
I
--
T
I
I
I
--
A
L
S
I
M
FF
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
---
P
I
I
V
I
G
V
-
G
A
Y
L
--
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
---
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
--
D
I
K
N
G
V
G
A
----
Q
--
P
I
E
I
K
-
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
-
E
-
A
-
P
-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
--
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
-
D
---
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
---
S
I
I
Q
-
E
A
L
---
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
-
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.99
32%
-97
- C1 -
2ONJ
4
Y1866_STAAM
B:
[8-578]
---------------------------------------------------------------------------------------------------
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
----
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
-
I
N
N
H
A
L
-
T
-
T
-
D
E
K
V
H
H
L
T
I
AIGIA
L
F
I
F
V
I
V
R
P
P
-
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
------
R
K
K
--
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
--
F
I
L
T
G
L
M
N
I
W
---
L
-
D
-
C
I
--
T
I
I
I
--
A
L
S
I
M
FF
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
---
P
I
I
V
I
G
V
-
G
A
Y
L
--
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
---
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
--
D
I
K
N
G
V
G
A
----
Q
--
P
I
E
I
K
-
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
-
E
-
A
-
P
-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
--
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
-
D
---
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
---
S
I
I
Q
-
E
A
L
---
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
-
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.72
32%
-97
- C1 -
2ONJ
4
Y1866_STAAM
A:
[8-578]
---------------------------------------------------------------------------------------------------
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
----
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
-
I
N
N
H
A
L
-
T
-
T
-
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
-
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
------
R
K
K
--
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
--
F
I
L
T
G
L
M
N
I
W
---
L
-
D
-
C
I
--
T
I
I
I
--
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
---
P
I
I
V
I
G
V
-
G
A
Y
L
--
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
---
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
--
D
I
K
N
G
V
G
A
----
Q
--
P
I
E
I
K
-
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
-
E
-
A
-
P
-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
--
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
-
D
---
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
---
S
I
I
Q
-
E
A
L
---
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
-
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.44
32%
-96
- C1 -
2HYD
3
Y1866_STAAM
A:
[8-578]
---------------------------------------------------------------------------------------------------
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
----
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
-
I
N
N
H
A
L
-
T
-
T
-
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
-
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
------
R
K
K
--
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
--
F
I
L
T
G
L
M
N
I
W
---
L
-
D
-
C
I
--
T
I
I
I
--
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
---
P
I
I
V
I
G
V
-
G
A
Y
L
--
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
---
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
--
D
I
K
N
G
V
G
A
----
Q
--
P
I
E
I
K
-
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
-
E
-
A
-
P
-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
--
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
-
D
---
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
---
S
I
I
Q
-
E
A
L
---
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
-
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.56
33%
-97
- C1 -
4Q4A
1
Y288_THEMA
B:
[33-590]
--------------------------------------------------------------------------------------------------------
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
-
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
-
F
V
P
-
R
--
R
-
F
-
D
L
L
P
R
Y
M
L
I
-----
L
--------
G
-
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
--
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
-
T
L
A
G
--
A
V
I
----
M
M
F
R
--
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
---
F
A
L
I
S
G
F
-
G
G
W
L
--
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
---
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
--
E
K
D
D
P
D
A
V
----
E
--
L
R
-
E
V
-
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-
K
-
K
-
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
--
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
-
D
---
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
---
K
S
I
Q
-
A
A
M
---
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
-
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.86
33%
-97
- C1 -
3QF4
1
Y288_THEMA
B:
[33-590]
--------------------------------------------------------------------------------------------------------
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
-
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
-
F
V
P
-
R
--
R
-
F
-
D
L
L
P
R
Y
M
L
I
-----
L
--------
G
-
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
--
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
-
T
L
A
G
--
A
V
I
----
M
M
F
R
--
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
---
F
A
L
I
S
G
F
-
G
G
W
L
--
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
---
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
--
E
K
D
D
P
D
A
V
----
E
--
L
R
-
E
V
-
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-
K
-
K
-
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
--
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
-
D
---
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
---
K
S
I
Q
-
A
A
M
---
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
-
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.20
33%
-93
- C1 -
4Q4H
-
Y288_THEMA
B:
[33-590]
--------------------------------------------------------------------------------------------------------
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
-
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
-
F
V
P
-
R
--
R
-
F
-
D
L
L
P
R
Y
M
L
I
-----
L
--------
G
-
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
--
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
-
T
L
A
G
--
A
V
I
----
M
M
F
R
--
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
---
F
A
L
I
S
G
F
-
G
G
W
L
--
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
---
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
--
E
K
D
D
P
D
A
V
----
E
--
L
R
-
E
V
-
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-
K
-
K
-
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
--
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
-
D
---
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
---
K
S
I
Q
-
A
A
M
---
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
-
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.52
32%
-94
- C1 -
4Q4J
-
Y288_THEMA
B:
[33-590]
--------------------------------------------------------------------------------------------------------
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
-
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
-
F
V
P
-
R
--
R
-
F
-
D
L
L
P
R
Y
M
L
I
-----
L
--------
G
-
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
--
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
-
T
L
A
G
--
A
V
I
----
M
M
F
R
--
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
---
F
A
L
I
S
G
F
-
G
G
W
L
--
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
---
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
--
E
K
D
D
P
D
A
V
----
E
--
L
R
-
E
V
-
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-
K
-
K
-
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
--
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
-
D
---
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
---
K
S
I
Q
-
A
A
M
---
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
-
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
79.56
27%
-88
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[6-572]
-------------------------------------------------------------------------------------------
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
----
S
V
-
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
-
Y
T
N
-
P
T
V
D
-
Y
S
D
N
L
T
R
L
C
L
G
-----
L
S
A
V
F
L
C
G
A
A
-
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
------
R
T
S
--
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
--
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
-
S
V
--
G
I
S
---
M
M
-
F
F
--
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
---
V
L
S
V
L
Y
K
-
G
G
L
L
--
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
---
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
--
K
L
P
F
N
E
G
V
----
I
L
-
N
E
-
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
P
E
-
V
-
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
--
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
PSS
V
-
T
-
A
---
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
---
Y
L
V
Q
-
E
A
L
---
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
-
K
P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
79.29
28%
-92
- C1 -
4AYX
7
ABCBA_HUMAN
A:
[9-574]
---------------------------------------------------------------------------------------------
K
L
L
G
L
A
Y
P
E
R
-
R
R
L
A
A
A
V
G
F
L
T
M
S
----
S
V
-
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
-
T
V
-
D
Y
S
-
D
N
L
T
R
L
C
L
G
-----
L
S
A
V
F
L
C
G
A
A
-
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
------
R
T
S
--
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
--
S
V
---
T
E
N
L
S
D
G
L
R
-
A
-
G
A
Q
A
S
V
G
I
--
S
M
M
F
F
--
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
----
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
--
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
---
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
--
K
L
P
F
N
E
G
V
----
I
L
N
E
K
-
S
F
-
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
-
P
-
E
V
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
--
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
-
S
VT
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
---
Y
L
V
Q
-
E
A
L
---
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
--
N
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
78.93
28%
-91
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[9-572]
---------------------------------------------------------------------------------------------
K
L
L
G
L
A
Y
P
E
R
-
R
R
L
A
A
A
V
G
F
L
T
M
S
----
S
V
-
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
-
T
V
-
D
Y
S
-
D
N
L
T
R
L
C
L
G
-----
L
S
A
V
F
L
C
G
A
A
-
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
------
R
T
S
--
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
--
S
V
---
T
E
N
L
S
D
G
L
R
-
A
-
G
A
Q
A
S
V
G
I
--
S
M
M
F
F
--
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
----
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
--
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
---
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
--
K
L
P
F
N
E
G
V
----
I
L
N
E
K
-
S
F
-
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
-
P
-
E
V
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
--
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
-
S
VT
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
---
Y
L
V
Q
-
E
A
L
---
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
78.62
28%
-83
- C1 -
3B60
2
MSBA_SALTY
A:
[12-581]
-------------------------------------------------------------------------------------------
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
----
A
A
-
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
-
F
G
K
-
T
D
R
S
-
V
---
L
L
W
M
P
L
V
-----
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
------
R
R
R
--
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
--
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
-
I
G
--
L
F
I
---
M
M
-
F
Y
--
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
---
L
A
F
V
L
Y
A
-
A
S
F
P
--
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
---
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
R
--------
V
I
-
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
-
G
R
-
E
-
V
-
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
--
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
---
Y
-
S
-
R
---
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
---
R
A
I
Q
-
A
A
L
---
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
-
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
78.26
28%
-93
- C1 -
4AYW
3
ABCBA_HUMAN
A:
[40-598]
---------------------------------------------------------------------------------------------
K
L
L
G
L
A
Y
P
E
R
-
R
R
L
A
A
A
V
G
F
L
T
M
S
----
S
V
-
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
-
T
V
-
D
Y
S
-
D
N
L
T
R
L
C
L
G
-----
L
S
A
V
F
L
C
G
A
A
-
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
------
R
T
S
--
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
--
S
V
---
T
E
N
L
S
D
G
L
R
-
A
-
G
A
Q
A
S
V
G
I
--
S
M
M
F
F
--
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
----
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
--
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
---
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
--
K
L
P
F
N
E
G
V
----
I
L
N
E
K
-
S
F
-
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
-
P
-
E
V
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
--
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
-
S
VT
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
---
Y
L
V
Q
-
E
A
L
---
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Fugue
77.99
27%
-83
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
-----------------------------------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
----
A
A
-
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
-
F
G
K
-
T
--
D
-
R
-
S
V
L
L
W
M
P
L
V
-----
V
I
G
L
M
I
L
R
G
I
-
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
------
R
R
R
--
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
--
S
S
S
G
A
L
I
T
V
V
R
E
G
A
-
S
-
I
I
--
G
L
F
I
--
M
M
F
Y
Y
---
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
---
L
A
F
V
L
Y
A
-
A
S
F
P
--
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
---
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
R
V
----
I
--
D
R
-
A
T
--
G
D
L
E
F
R
N
V
T
F
T
Y
P
-
G
R
-
E
-
V
-
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
--
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
-
Y
S
R
---
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
---
R
A
I
Q
-
A
A
L
---
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
-
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.65
28%
-89
- C1 -
4AYT
8
ABCBA_HUMAN
A:
[9-567]
---------------------------------------------------------------------------------------------
K
L
L
G
L
A
Y
P
E
R
-
R
R
L
A
A
A
V
G
F
L
T
M
S
----
S
V
-
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
-
T
V
-
D
Y
S
-
D
N
L
T
R
L
C
L
G
-----
L
S
A
V
F
L
C
G
A
A
-
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
------
R
T
S
--
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
--
S
V
---
T
E
N
L
S
D
G
L
R
-
A
-
G
A
Q
A
S
V
G
I
--
S
M
M
F
F
--
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
----
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
--
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
---
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
--
K
L
P
F
N
E
G
V
----
I
L
N
E
K
-
S
F
-
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
-
P
-
E
V
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
--
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
-
S
VT
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
---
Y
L
V
Q
-
E
A
L
---
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.96
32%
-95
- C1 -
4A82
-
Y1866_STAAM
A:
[8-578]
---------------------------------------------------------------------------------------------------
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
----
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
-
I
N
N
H
A
L
-
T
-
T
-
D
E
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
-
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
------
R
K
K
--
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
--
F
I
L
T
G
L
M
N
I
W
---
L
-
D
-
C
I
--
T
I
I
I
--
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
---
P
I
I
V
I
G
V
-
G
A
Y
L
--
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
---
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
--
D
I
K
N
G
V
G
A
----
Q
--
P
I
E
I
K
-
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
-
D
N
-
E
-
A
-
P
-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
--
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
-
D
---
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
---
S
I
I
Q
-
E
A
L
---
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
-
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
76.59
26%
-91
- C1 -
3WMG
5
?
A:
[29-598]
----------------------------------------------------------------------------------------------------------
I
V
I
G
F
I
A
S
I
L
E
----
G
A
-
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
-
T
K
S
-
K
S
-
Q
I
E
-
G
E
T
W
K
Y
S
V
G
-----
F
V
G
I
G
V
F
E
F
I
-
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
------
R
V
A
--
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
--
S
F
S
K
L
G
-
A
V
L
F
N
L
A
Q
C
-
V
V
--
G
I
I
---
V
A
-
F
I
--
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
---
Y
A
L
A
L
W
W
-
G
G
Q
L
--
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
---
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
--
Q
Y
R
R
P
D
P
G
A
E
V
V
T
--
Q
P
-
L
V
L
K
Q
G
I
V
F
E
N
V
H
F
R
Y
P
-
T
R
-
M
N
V
-
E
-
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
--
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
-
K
R
-
D
---
A
-
T
-
D
---
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
---
A
L
V
Q
-
E
A
L
---
D
R
M
M
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
-
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.93
31%
-78
- C1 -
3B60
2
MSBA_SALTY
A:
[59-579]
----------------------------------------------------------------------------------------------------------------------------------------------------
T
-
D
-
R
S
V
L
L
W
M
P
L
-----
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
------
R
R
R
--
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
---
E
Q
--
V
A
S
S
S
S
G
A
L
I
T
V
V
R
-
E
-
G
A
--
S
I
I
G
L
F
I
M
M
F
Y
--
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
---
L
A
F
V
L
-
Y
-
A
A
S
F
PS
V
M
D
-
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
---
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
R
V
----
I
--
D
R
-
A
--
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
-
G
R
-
E
-
V
-
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
--
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
-
R
---
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
---
R
A
I
Q
-
A
A
L
---
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
-
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
75.78
31%
-78
- C1 -
3B60
2
MSBA_SALTY
D:
[59-579]
----------------------------------------------------------------------------------------------------------------------------------------------------
T
-
D
-
R
S
V
L
L
W
M
P
L
-----
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
------
R
R
R
--
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
---
E
Q
--
V
A
S
S
S
S
G
A
L
I
T
V
V
R
-
E
-
G
A
--
S
I
I
G
LF
I
M
M
F
Y
--
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
---
L
A
F
V
L
-
Y
-
A
A
S
F
PS
V
M
D
-
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
---
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
--
E
K
D
E
G
K
R
V
----
I
--
D
R
-
A
--
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
-
G
R
-
E
-
V
-
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
--
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
-
R
---
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
---
R
A
I
Q
-
A
A
L
---
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
-
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Fugue
75.53
27%
-90
- C1 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
L
---------------
P
T
G
Q
N
Y
T
K
T
D
F
-
E
H
D
-
V
M
-
N
------
V
V
W
S
Y
A
-----
A
M
T
V
G
M
W
A
A
G
-
Q
I
T
V
T
C
Y
L
Y
V
A
--
E
Q
M
N
N
R
L
------
R
R
E
--
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
-
I
-
T
G
--
F
I
V
A
--
F
T
H
-----
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
---
F
A
L
A
F
Y
I
-
G
V
G
W
--
V
H
D
G
S
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
---
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
P
VI
D
S
S
S
K
A
G
R
----
K
--
D
M
-
K
I
-
K
G
D
I
T
V
E
N
V
H
F
T
Y
P
-
S
R
-
P
-
D
V
P
-
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
--
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
-
K
E
-
G
---
I
-
T
-
R
---
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
---
G
I
V
Q
-
Q
A
L
---
D
K
A
A
--
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
-
Q
--
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
G
E
R
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
109
HHSearch
55.10
41%
-86
- C1 -
2FF7
1
A:
[5-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
D
I
T
F
R
N
I
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
-
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
54.85
41%
-87
- C1 -
1XEF
3
D:
[8-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
54.81
41%
-89
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[14-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
54.75
41%
-94
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[8-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
54.27
41%
-89
- C1 -
2FGK
2
D:
[14-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
54.18
41%
-89
- C1 -
2FGJ
2
D:
[14-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
54.17
41%
-86
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[14-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
54.09
41%
-85
- C1 -
2FFA
2
A:
[14-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
54.05
41%
-89
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[8-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
53.81
34%
-92
* C1 *
3VX4
3
?
A:
[29-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
G
-
F
G
---
R
-
D
-
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
--
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
-
A
K
-
E
G--
T
-
S
-
Q
---
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
---
K
K
I
I
-
S
N
L
---
L
Q
M
---
T
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
-
K
--
Q
G
F
Y
Y
N
L
F
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
53.70
41%
-85
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[14-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
53.69
37%
-87
- C1 -
3VX4
3
?
D:
[28-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
-
F
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
G
F
-
G
-
R
-
D
-
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
IV
R
I
N
G
N
D
L
K
V
I
D
K
T
--
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
A
K
E
-
G
---
T
-
S
-
Q
---
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
---
K
K
I
I
-
S
N
L
---
L
Q
-
M
--
T
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
-
K
--
Q
G
F
Y
Y
N
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
53.64
41%
-89
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[14-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
53.59
41%
-89
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[8-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
53.57
41%
-88
- C1 -
2FF7
1
A:
[14-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
53.49
41%
-87
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[14-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
53.12
41%
-86
- C1 -
2FFB
1
A:
[14-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
52.88
37%
-90
- C1 -
3VX4
3
?
A:
[29-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
F
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
G
F
-
G
-
R
-
D
-
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
--
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
A
K
E
-
G
---
T
-
S
-
Q
---
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
---
K
K
I
I
-
S
N
L
---
L
Q
-
M
--
T
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
-
K
--
Q
G
F
Y
Y
N
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
52.81
41%
-86
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[14-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
52.55
41%
-86
- C1 -
2PMK
1
A:
[10-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
49.41
41%
-82
- C1 -
3B5J
1
A:
[10-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
R
Y
K
-
P
D
-
S
-
P
-
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
--
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
-
S
-
V
---
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
-
R
N
M
---
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
48.85
38%
-78
- C1 -
1JJ7
2
A:
[21-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
A
Y
P
-
N
R
-
P
-
D
-
V
L
V
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
--
Q
L
L
L
D
G
K
P
L
P
Q
Y
E
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
G
R
S
L
Q
E
N
I
A
Y
G
-
L
T
-
Q
---
K
-
P
T
M
---
E
E
I
T
A
A
A
V
K
S
G
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
-
Y
E
S
---
P
E
R
Y
--
S
R
S
V
L
L
I
T
Q
H
-
L
S
L
V
E
Q
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
-
K
--
K
G
C
Y
W
A
M
V
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
47.78
34%
-75
- C1 -
1MV5
3
LMRA_LACLA
A:
[2-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
D
-
D
S
---
E
-
Q
-
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
--
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
-
L
E
-
G
D--
Y
-
T
-
D
---
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
---
S
M
V
Q
-
K
A
L
---
D
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
-
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
45.85
35%
-79
- C1 -
1MV5
3
LMRA_LACLA
C:
[9-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
Y
--
D
D
-
S
-
E
-
Q
-
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
--
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
-
D
---
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
---
S
M
V
Q
-
K
A
L
---
D
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
-
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
45.36
35%
-73
- C1 -
1MV5
3
D:
[9-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
Y
--
D
D
-
S
-
E
-
Q
-
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
--
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
-
D
---
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
---
S
M
V
Q
-
K
A
L
---
D
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
-
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
45.28
35%
-76
- C1 -
1MV5
3
LMRA_LACLA
A:
[9-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
Y
--
D
D
-
S
-
E
-
Q
-
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
--
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
-
D
---
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
---
S
M
V
Q
-
K
A
L
---
D
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
-
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
43.35
36%
-69
- C1 -
2CBZ
2
A:
[11-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
W
A
-
R
S
-
D
-
P
-
P
-
T
L
N
G
I
T
F
S
I
P
E
G
A
L
V
A
V
V
G
Q
V
G
C
G
K
S
S
L
L
S
A
L
L
A
E
M
D
K
V
---
E
G
--
H
V
A
-------------
I
K
G
S
V
A
Y
V
P
Q
Q
A
W
I
Q
N
D
S
L
R
E
N
I
L
F
G
C
Q
L
-
E
---
E
-
P
-
Y
---
Y
R
S
V
I
Q
A
C
A
L
L
P
D
L
E
I
L
--
P
S
G
D
R
T
E
I
G
E
K
G
V
N
L
S
G
G
Q
K
Q
R
V
S
L
A
R
A
V
Y
S
N
A
D
I
Y
L
F
D
D
P
L
S
A
V
D
A
H
V
G
---
K
H
I
F
-
E
N
V
IGP
K
G
M
L
--
K
N
K
T
R
I
L
V
T
H
S
M
S
Y
L
P
Q
V
D
V
I
I
V
M
S
G
G
K
I
S
E
M
G
S
Y
Q
E
L
L
A
-
R
--
D
G
A
F
A
E
F
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
39.97
35%
-66
- C1 -
1MV5
2
LMRA_LACLA
B:
[9-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
Y
--
D
D
-
S
-
E
-
Q
-
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
--
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
-
D
---
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
---
S
M
V
Q
-
K
A
L
---
D
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
-
T
--
H
P
L
Y
A
K
Y
V
S
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
39.81
31%
-73
- C1 -
1Q3H
3
D:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
38.82
31%
-74
- C1 -
1R0Y
3
D:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
38.65
31%
-68
- C1 -
1R0Z
3
D:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
38.22
31%
-69
- C1 -
1R10
3
B:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
38.13
31%
-69
- C1 -
1Q3H
4
CFTR_MOUSE
A:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
37.91
31%
-71
- C1 -
1R0X
5
CFTR_MOUSE
A:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
37.70
31%
-65
- C1 -
1R0Z
3
CFTR_MOUSE
C:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
37.52
31%
-73
- C1 -
1R0X
4
D:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
37.38
31%
-69
- C1 -
1R0X
3
CFTR_MOUSE
C:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
37.18
31%
-65
- C1 -
1R0Z
4
CFTR_MOUSE
A:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
36.85
31%
-72
- C1 -
1Q3H
3
CFTR_MOUSE
C:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
36.67
31%
-70
- C1 -
1R10
5
CFTR_MOUSE
A:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
36.24
31%
-66
- C1 -
1Q3H
3
CFTR_MOUSE
B:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
36.23
31%
-69
- C1 -
1R0Y
2
CFTR_MOUSE
B:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
36.20
31%
-65
- C1 -
1R0Z
3
CFTR_MOUSE
B:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
36.09
31%
-65
- C1 -
1R0Y
2
CFTR_MOUSE
C:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
35.91
31%
-69
- C1 -
1R0X
3
CFTR_MOUSE
B:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
34.92
31%
-69
- C1 -
1R0Y
4
CFTR_MOUSE
A:
[52-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
--
I
I
K
H
S
G
-------------
R
V
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
I
F
G
--
V
-
S
---
Y
-
D
-
E
---
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
---
E
Q
V
F
E
S
C
V
---
C
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
S
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------