@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1664: (2016-03-27 )
LAKNRHLFTSESVSDGHPDKIADQISDAILDAIISKDPDARVACETTVTTGLVLVAGEITTSVYVDIPKIVRDTIKEIGYTRAKYGFDAETCAVLTAIDEQSPDIAQGVDEALESRSGNEIDAAIEAIGAGDQGLMFGFATDETEELMPLPIFLAHGLARKLTELRKTNKLDYLRPDAKTQVTVEYDEFNQPVRIDTIVVSTQHHPDITQEQIAKDLHTYLFPEVIDASFLDEDTKYFINPTGRFVIGGPLGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSGAYAARYVAKNIVAAGLAKKVEVQVAYAIGVARPVSISIDTYGTSDYSEQELIDGVNALFDLRPAGIIHMLDLRRPIYRQTAAFGHFGRSDLDLPWERTDKAEALKKLIVK
Atome Classification :
(28 SA)
.........10........20........30........40........50........60..---......70........80........90........100.......110--.......120.......130.......140.......150.......160.....---..170.......180.......---190-.---........200.......210.-.......220.....---..230.----.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330..--.....340.......350.......360.......370.......380.......390.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LAKNR
H
L
FTSESVSDGH
P
D
K
I
A
D
Q
I
S
D
A
I
L
D
A
I
ISKDPDA
R
V
A
C
E
T
TVT
T
G
L
V
L
V
A
G
E
I
T
T
S
V
---
Y
VD
I
P
K
I
V
R
D
T
I
K
E
IGYTRAKYGFD
A
E
T
C
A
V
L
T
AIDEQS
P
D
I
A
Q
G
V
D
E
A
--
L
E
SRSGN
E
I
D
A
A
I
E
A
IGAGDQ
G
L
M
F
G
FATDETEELMP
L
P
I
F
L
A
H
G
L
A
R
K
L
T
E
L
R
K---TNKL
D
Y
LRPDA
K
T
Q
V
T
V
E
Y
DEF---N---Q---
P
V
R
I
D
T
I
V
V
STQHHPDI
T
Q
-
E
Q
-
I
A
K
D
L
H
T
Y
L
F
P
E
V
I
D
---
A
S
FL-D----EDT
K
Y
F
INPTG
R
F
V
I
GGPLGDAGLTG
R
K
I
I
V
DTYGGYARHGGGAFSGKDPTKVDRSG
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
GLA
K
K
V
E
V
Q
V
A
Y
A
IGVA
R
P
V
S
I
S
I
D
TYGTSD--Y
S
E
Q
E
L
I
D
G
V
N
A
L
FDLRPA
G
I
I
H
M
L
DLR
R
P
I
Y
R
Q
T
A
AFGHFGRSDLDLPWERT
D
K
A
E
A
L
K
K
L
IVK
50
HHSearch
97.79
63%
-79
- C4 -
1P7L
8
METK_ECOLI
A:
[1-381]
---
A
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
-------------
D
P
L
E
Q
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
----
G
---
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
-
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
----
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
-
21
PsiBlast_CBE
96.79
61%
-78
- C4 -
1RG9
9
METK_ECOLI
D:
[2-377]
----
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
DP
L
E
Q
-------------
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
----
G
---
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
-
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
----
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
22
PsiBlast_CBE
96.44
61%
-78
- C4 -
1RG9
9
METK_ECOLI
C:
[2-377]
----
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
DP
L
E
Q
-------------
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
----
G
---
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
-
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
----
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
3
PsiBlast_PDB
96.33
61%
-78
- C4 -
1RG9
8
METK_ECOLI
A:
[2-377]
----
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
DP
L
E
Q
-------------
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
----
G
---
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
-
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
----
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
25
PsiBlast_CBE
96.25
61%
-77
- C4 -
1P7L
9
METK_ECOLI
C:
[2-377]
----
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
DP
L
E
Q
-------------
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
----
G
---
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
-
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
----
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
2
PsiBlast_PDB
96.22
61%
-78
- C4 -
1P7L
8
METK_ECOLI
A:
[2-377]
----
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
DP
L
E
Q
-------------
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
----
G
---
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
-
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
----
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
24
PsiBlast_CBE
96.16
61%
-78
- C4 -
1P7L
8
METK_ECOLI
D:
[2-377]
----
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
DP
L
E
Q
-------------
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
----
G
---
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
-
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
----
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
23
PsiBlast_CBE
95.88
61%
-77
- C4 -
1RG9
8
METK_ECOLI
B:
[2-377]
----
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
DP
L
E
Q
-------------
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
----
G
---
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
-
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
----
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
49
HHSearch
95.82
60%
-78
- C4 -
2P02
2
METK2_HUMAN
A:
[17-395]
---
G
T
F
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
H
L
D
--
R
----------
N
E
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
RG
A
V
---
L
---
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
-
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
V
P
K
K
L
K
--------
26
PsiBlast_CBE
95.79
61%
-78
- C4 -
1P7L
8
METK_ECOLI
B:
[2-377]
----
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
D
R
A
DP
L
E
Q
-------------
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
----
G
---
K
---
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
-
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
----
S
A
T
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
-----
14
PsiBlast_PDB
95.32
59%
-80
- C4 -
2P02
2
METK2_HUMAN
A:
[20-389]
------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
------------
H
L
D
R
N
E
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
---
R
---
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
-
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
--------------
43
PsiBlast_CBE
95.12
59%
-82
- C4 -
4NDN
9
METK2_HUMAN
B:
[19-388]
------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
------------
H
L
D
R
N
E
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
---
R
---
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
-
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
--------------
38
PsiBlast_CBE
95.10
59%
-82
- C4 -
4KTT
6
METK2_HUMAN
D:
[20-389]
------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
------------
H
L
D
R
N
E
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
---
R
---
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
-
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
--------------
40
PsiBlast_CBE
94.75
59%
-80
- C4 -
4KTT
14
METK2_HUMAN
B:
[20-389]
------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
------------
H
L
D
R
N
E
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
---
R
---
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
-
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
--------------
35
PsiBlast_CBE
94.60
59%
-82
- C4 -
4KTV
8
METK2_HUMAN
D:
[20-389]
------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
------------
H
L
D
R
N
E
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
---
R
---
G
AVL
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
-
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
--------------
41
PsiBlast_CBE
94.58
59%
-82
- C4 -
4NDN
6
METK2_HUMAN
D:
[19-388]
------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
------------
H
L
D
R
N
E
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
---
R
---
G
AVL
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
-
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
--------------
37
PsiBlast_CBE
93.78
59%
-83
- C4 -
4KTV
7
METK2_HUMAN
B:
[20-389]
------
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
------------
H
L
D
R
N
E
E
D
I
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
---
R
---
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
-
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
--------------
7
PsiBlast_PDB
93.50
60%
-82
- C4 -
2OBV
6
METK1_HUMAN
A:
[8-377]
------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
V
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
C
V
------------
H
L
D
R
N
E
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
I
L
A
H
K
L
N
A
R
M
A
D
L
R
R
---
S
G
L
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
---
N
---
G
A
V
I
P
V
R
I
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
E
-
M
R
R
A
L
K
E
Q
V
I
R
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
V
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
Q
--
K
T
E
R
E
L
L
D
V
V
H
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
--------------
28
PsiBlast_CBE
92.75
57%
-81
- C4 -
3S82
5
METK_MYCA1
B:
[6-407]
-
S
E
K
G
R
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
-----------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
---
N
G
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
E
D
----
D
---
V
---
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
-
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
---
D
L
A
H
-
D
TLDT
S
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--
31
PsiBlast_CBE
92.73
59%
-84
- C4 -
1O9T
8
METK1_RAT
A:
[20-389]
------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
------------------------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
---
N
---
G
A
V
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
A
-
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
--------------
8
PsiBlast_PDB
92.68
59%
-86
- C4 -
1QM4
9
METK1_RAT
A:
[20-389]
------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
------------------------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
---
N
---
G
A
V
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
A
-
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
--------------
48
HHSearch
92.51
58%
-82
- C4 -
3S82
5
METK_MYCA1
A:
[9-407]
----
G
R
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
-----------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
---
N
G
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
E
D
----
D
---
V
---
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
E
N
T
-
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
A
H
D
T
L
D
T
----
S
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--
9
PsiBlast_PDB
92.46
59%
-85
- C4 -
1O90
8
METK1_RAT
A:
[20-389]
------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
------------------------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
---
N
---
G
A
V
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
A
-
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
--------------
10
PsiBlast_PDB
92.40
59%
-84
- C4 -
1O92
9
METK1_RAT
A:
[20-389]
------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
------------------------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
---
N
---
G
A
V
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
A
-
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
--------------
18
PsiBlast_PDB
92.30
50%
-76
- C4 -
4ODJ
4
?
A:
[30-409]
----
Q
F
L
F
S
S
E
S
V
C
S
G
H
P
D
K
L
C
D
Q
I
S
D
A
I
L
D
A
C
L
E
Q
D
P
E
S
F
V
A
C
E
T
C
T
K
T
G
F
I
M
V
F
G
E
I
T
T
K
A
---
N
V
N
Y
E
R
V
V
R
E
T
V
K
E
I
G
Y
D
S
E
E
K
G
L
D
Y
K
T
M
D
V
I
I
K
L
E
Q
Q
S
N
Q
I
A
G
C
V
------------
H
V
D
K
N
V
E
D
I
G
A
G
D
Q
G
M
M
F
G
Y
A
T
N
E
T
K
E
L
M
P
L
T
H
V
L
A
T
S
I
T
R
E
L
D
Y
I
R
M
KGV
S
S
R
V
G
W
L
R
P
D
G
K
A
Q
V
T
V
E
Y
N
C
K
---
H
---
G
V
L
I
P
K
R
I
H
T
I
L
V
S
V
Q
H
D
E
N
I
E
N
-
E
E
-
I
R
E
F
V
L
E
N
V
I
K
K
V
C
P
---
S
D
L
M
-
D
----
K
E
T
R
I
L
I
N
P
S
G
R
F
T
I
G
G
P
A
A
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
A
T
K
V
D
R
S
G
A
Y
M
A
R
L
V
A
K
S
I
V
F
S
G
L
C
S
R
C
L
V
Q
V
S
Y
G
I
G
I
A
R
P
L
S
L
Y
I
N
T
F
G
T
A
K
DG
Y
N
D
T
K
L
L
E
I
V
N
K
V
F
D
F
R
P
G
I
L
I
K
Q
L
N
L
K
S
P
I
F
K
K
T
S
S
G
G
H
F
G
R
S
E
K
E
F
L
W
E
K
-------------
11
PsiBlast_PDB
92.17
59%
-84
- C4 -
1O93
8
METK1_RAT
A:
[20-389]
------
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
------------------------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
---
N
---
G
A
V
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
A
-
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
S
--
E
F
P
W
E
--------------
5
PsiBlast_PDB
91.72
57%
-81
- C4 -
3S82
5
METK_MYCA1
A:
[9-407]
----
G
R
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
-----------------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
---
N
G
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
E
D
----
D
---
V
---
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
-
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
---
D
L
A
H
-
D
TLDT
S
S
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--
64
Fugue
55.66
55%
-104
* C4 *
1QM4
4
METK1_RAT
A:
[129-251]
----------------------------------------------------------------------------------------------------------------------------------
E
D
V
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
---
N
G
A
V
I
---
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
A
-
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
----
E
D
T
I
Y
H
L
Q
P
S
G
R
F
------------------------------------------------------------------------------------------------------------------------------------------------------------