@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1672: (2016-03-27 )
MDMTNWLQKRVRLSPKETALVFEGKEETFEEISEAVERLAGKLFALGIRKDEMIALLGKNDRMTFLLIHALQQLGAVTLFLNNRLTKKEIAYQLANAEVKQVIVADTFEDKVGAGISYSELAETDYKEPELLETWDLSRTASIMYTSGTTGKPKGVIQTYENHWWSAVASVLNLGLTEKDSWLCAVPIFHISGLSIMMRSVIYGIPVYLEEHFDEEKITQLLESGKVSTISVVTSMLERLLKIHGGSYHPNVRTILLGGGPASKTVLEICKQRDIPLVQSFGMTETASQIVTLPPKDALNKIGSSGKALFPAEVKIADDGEILLKGPSITPGYLHNKKATEASFVDGWFKTGDIGYLDEEGFLFVVERRSDLIISGGENIYPTEIEHVIGEYVAVKEVAVIGQPDDKWGSVPVAFIVAEETFDEDELQLICQTNLASYKIPKQIIIVEKLPKTASGKIQRNKLKERHSK
Atome Classification :
(20 SA)
......-...10........20.--....--...30........40........50........60........70........80........90........100-----------....--------------.-------.---...110-----.----.------------------....-------------.----------..120.----...--..-.130.........140.........150.....--..160.......170---......--..180.......190..-.....200.--......210.......220.....--..230......--.240..---.--...--.--250........260-.......270.--...--...280.......290.-----......300.......310....-------------..---------.-----------320-------.......-..330.......340..-..-...350.......360.......370.......380.......390.......400.......410.......--420-..--......430....-.....440.......450.......460.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
M
T
N
W
-
L
Q
K
R
VRLSPK
E
T
A
L
V
F--EG
K
E
--
E
T
F
E
E
I
S
E
A
V
E
R
L
A
G
K
L
F
A
LGIRK
D
E
M
I
A
L
LGKND
R
M
T
F
L
L
I
H
A
L
Q
QL
G
A
V
T
L
F
LNNRL
T
K
K
E
I
A
Y
Q
L
ANA
E
V
K
-------------
Q
V
I
V
--------------A-------D---TF
E
D
-------K----V------------------GAGI-------------
S
----------
Y
S
E
L
AE----TDY--KE-P
E
--
L
L
E
T
WDLS
R
T
--
A
S
I
M
Y
TSGTTGKPK
G
V
I
--
Q
T
Y
E
N
H
W
W
S
A
V
A
S
V
----
L
NLGLT--EKD
S
W
L
C
A
V
P
I
FHIS
G
L
-
S
I
M
M
R
S
V
I
Y--GI
P
V
Y
L
E
E
HF
D
E
E
K
I
T
Q
L
L
E
SGKV--
S
T
I
S
V
V
T
S
M
L
E
--
R
L
L
K
I
H---G--GSY--H--P-N
V
R
T
I
L
LGGGP
A
-
S
K
T
V
L
E
I
C
K
QR--D
I
P
--
L
V
Q
SFGMTETAS
Q
I
V
TL-----P
P
K
D
A
L
N
K
IGSSG
K
A
L
F
P
A
E
V
K
I-------------AD---------D-----------
G
---------
E
I
L
L
KGP-SITP
G
Y
LHNKKATEASF-VD-GWFKTGDIGYLDEEG
F
L
F
V
V
ERRS
D
L
I
I
SGGENI
Y
P
T
E
I
E
H
V
I
G
E
Y
V
A
V
K
E
V
A
V
IGQPDDKWGSV
P
V
A
F
I
V
AE--E-T-F
D
--
E
D
E
L
Q
L
I
--
C
QTN-LASYKIP
K
Q
I
I
I
V
EKLPKTASGK
I
Q
R
N
K
L
K
E
R
HSK
22
PsiBlast_CBE
97.97
44%
-113
- C4 -
5BUQ
2
?
B:
[9-481]
----
N
W
-
L
M
Q
R
A
Q
L
T
P
E
R
I
A
L
I
Y
--
E
D
Q
T
--
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
-------------
F
L
L
T
--------------
D
-------
S
---
S
F
E
K
-------
K
EYEH
I
------------------
V
Q
T
I
-------------
D
----------
V
D
E
L
M
K
----
E
A
A
--
E
E
-
I
E
--
I
E
A
Y
M
Q
M
D
A
T
--
A
T
L
M
Y
T
S
----
K
P
K
G
V
Q
--
Q
T
F
G
N
H
Y
F
S
A
V
S
S
A
----
L
N
L
G
I
T
--
E
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
G
L
-
S
A
L
F
K
S
V
I
Y
--
G
M
T
V
V
L
H
Q
R
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
--
T
M
I
S
A
V
Q
T
M
L
A
--
S
L
L
E
-
E
---
T
--
N
R
C
--
P
--
E
-
S
I
R
C
I
L
L
G
G
G
P
A
-
P
L
P
L
L
E
E
C
R
E
K
--
G
F
P
--
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
-----
S
P
E
F
S
M
E
K
L
G
S
A
G
K
P
L
F
S
C
E
I
K
I
-------------
E
R
---------
D
-----------
G
Q
V
C
E
PYEH
G
E
I
M
V
K
G
P
-
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
-
Q
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
---
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
----
V
P
H
A
Y
L
V
L
H
--
K
-
P
-
V
S
--
A
G
E
L
T
D
Y
--
C
K
E
R
-
L
A
K
Y
K
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
----
2
PsiBlast_PDB
97.06
44%
-106
- C4 -
5BUS
3
?
A:
[9-481]
----
N
W
-
L
M
Q
R
A
Q
L
T
P
E
R
I
A
L
I
Y
--
E
D
Q
T
--
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
-------------
F
L
L
T
--------------
D
-------
S
---
S
F
E
K
-------
K
EYEH
I
------------------
V
Q
T
I
-------------
D
----------
V
D
E
L
M
K
----
E
A
A
--
E
E
-
I
E
--
I
E
A
Y
M
Q
M
D
A
T
--
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
--
Q
T
F
G
N
H
Y
F
S
A
V
S
S
A
----
L
N
L
G
I
T
--
E
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
G
L
-
S
A
L
F
K
S
V
I
Y
--
G
M
T
V
V
L
H
Q
R
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
--
T
M
I
S
A
V
Q
T
M
L
A
--
S
L
L
E
-
E
---
T
--
N
R
C
--
P
--
E
-
S
I
R
C
I
L
L
G
G
G
P
A
-
P
L
P
L
L
E
E
C
R
E
K
--
G
F
P
--
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
-----
S
P
E
F
S
M
E
K
L
G
S
A
G
K
P
L
F
S
C
E
I
K
I
-------------
E
R
---------
D
-----------
G
Q
V
C
E
P
Y
E
H
G
E
I
M
V
K
G
P
-
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
-
Q
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
K
--
K
V
P
H
A
Y
L
V
L
H
--
K
-
P
-
V
S
--
A
G
E
L
T
D
Y
--
C
K
E
R
-
L
A
K
Y
K
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
----
1
PsiBlast_PDB
95.96
44%
-105
- C4 -
5BUR
9
?
A:
[9-481]
----
N
W
-
L
M
Q
R
A
Q
L
T
P
E
R
I
A
L
I
Y
--
E
D
Q
T
--
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
-------------
F
L
L
T
--------------
D
-------
S
---
S
F
E
K
-------
K
EYEH
I
------------------
V
Q
T
I
-------------
D
----------
V
D
E
L
M
K
----
E
A
A
--
E
E
-
I
E
--
I
E
A
Y
M
Q
M
D
A
T
--
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
--
Q
T
F
G
N
H
Y
F
S
A
V
S
S
A
----
L
N
L
G
I
T
--
E
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
G
L
-
S
A
L
F
K
S
V
I
Y
--
G
M
T
V
V
L
H
Q
R
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
--
T
M
I
S
A
V
Q
T
M
L
A
--
S
L
L
E
-
E
---
T
--
N
R
C
--
P
--
E
-
S
I
R
C
I
L
L
G
G
G
P
A
-
P
L
P
L
L
E
E
C
R
E
K
--
G
F
P
--
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
-----
S
P
E
F
S
M
E
K
L
G
S
A
G
K
P
L
F
S
C
E
I
K
I
-------------
E
R
---------
D
-----------
G
Q
V
C
E
PY
E
H
G
E
I
M
V
K
G
P
-
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
-
Q
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
--
G
K
V
P
H
A
Y
L
V
L
H
--
K
-
P
-
V
S
--
A
G
E
L
T
D
Y
--
C
K
E
R
-
L
A
K
Y
K
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
----
28
HHSearch
82.09
33%
-88
- C4 -
3R44
2
FAC13_MYCTU
A:
[16-512]
K
N
I
G
W
M
-
L
R
Q
R
A
T
V
S
P
R
L
Q
A
Y
V
E
PS
T
D
V
R
--
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
-------------
V
V
I
Y
--------------
G
-------
A
---
P
S
A
P
-------
V
----
I
------------------
D
A
I
R
-------------
A
QADPPGTVT
D
W
I
G
A
D
S
L
A
E
R
L
R
S
A-
A
A
-
D
E
--
P
A
V
E
C
G
G
D
D
N
--
L
F
I
M
Y
T
S
---
G
H
P
K
G
V
V
--
H
T
H
E
S
V
H
S
A
A
S
S
W
A
----
S
T
I
D
V
R
--
Y
R
D
R
L
L
L
P
L
P
M
F
H
V
A
A
L
-
T
T
V
I
F
S
A
M
R
--
G
V
T
L
I
S
M
P
Q
F
D
A
T
K
V
W
S
L
I
V
E
E
R
V
--
C
I
G
G
A
V
P
A
I
L
N
--
F
M
R
Q
V
P
---
E
F
A
E
L
D
--
A
--
P
-
D
F
R
Y
F
I
T
G
G
A
P
M
-
P
E
A
L
I
K
I
Y
A
A
K
--
N
I
E
--
V
V
Q
G
Y
A
L
T
E
S
C
G
G
G
T
L
L
-----
L
S
E
D
A
L
R
K
A
G
S
A
G
R
A
T
M
F
T
D
V
A
V
-------------
R
G
DDGVIREHG
E
-----------
G
---------
E
V
V
I
K
S
D
-
I
L
L
K
E
Y
W
N
R
P
E
A
T
R
D
A
F
-
D
N
-
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
G
E
I
A
A
A
I
V
V
A
D
--
Q
N
E
-
V
S
--
E
Q
Q
I
V
E
Y
--
C
G
T
R
-
L
A
R
Y
K
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
-
21
PsiBlast_CBE
82.03
44%
-113
- C4 -
5BUS
4
?
B:
[9-388]
----
N
W
-
L
M
Q
R
A
Q
L
T
P
E
R
I
A
L
I
Y
--
E
D
Q
T
--
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
-------------
F
L
L
T
--------------
D
-------
S
---
S
F
E
K
-------
K
EYEH
I
------------------
V
Q
T
I
-------------
D
----------
V
D
E
L
M
K
----
E
A
A
--
E
E
-
I
E
--
I
E
A
Y
M
Q
M
D
A
T
--
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
--
Q
T
F
G
N
H
Y
F
S
A
V
S
S
A
----
L
N
L
G
I
T
--
E
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
G
L
-
S
A
L
F
K
S
V
I
Y
--
G
M
T
V
V
L
H
Q
R
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
--
T
M
I
S
A
V
Q
T
M
L
A
--
S
L
L
E
-
E
---
T
----
C
--
P
--
E
-
S
I
R
C
I
L
L
G
G
G
P
--
P
L
P
L
L
E
E
C
R
E
K
--
G
F
P
--
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
-----
S
P
E
F
S
M
E
K
L
G
S
A
G
K
P
L
F
S
C
E
I
K
I
-------------
E
R
---------
D
-----------
G
Q
V
C
E
P
YEH
G
E
I
M
V
K
G
P
-
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
-
Q
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
----------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.34
33%
-89
- C4 -
3R44
2
FAC13_MYCTU
A:
[15-512]
M
K
N
I
G
W
M
L
R
Q
R
A
T
V
S
P
R
L
Q
A
Y
V
E
--
P
S
T
D
V
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
-------------
V
V
I
Y
G
APS
A
P
V
I
D
A
I
R
A
Q
A
-------
D
PPG
T
V
T
D
-------
W
----
I
------------------
G
A
D
S
-------------
L
----------
A
E
R
L
R
S
----
A
A
A
--
D
E
-
P
A
--
V
E
C
G
G
D
--
D
N
--
L
F
I
M
Y
T
S
---
G
H
P
K
G
V
V
--
H
T
H
E
S
V
H
S
A
A
S
S
W
A
----
S
T
I
D
V
R
--
Y
R
D
R
L
L
L
P
L
P
M
F
H
V
A
A
L
-
T
T
V
I
F
S
A
M
R
--
G
V
T
L
I
S
M
P
Q
F
D
A
T
K
V
W
S
L
I
V
E
E
R
V
--
C
I
G
G
A
V
P
A
I
L
N
--
F
M
R
Q
V
P
---
E
--
F
A
E
LD
A
--
P
-
D
F
R
Y
F
I
T
G
G
A
P
M
-
P
E
A
L
I
K
I
Y
A
A
K
--
N
I
E
--
V
V
Q
G
Y
A
L
T
E
S
C
G
G
G
T
L
L
-----
L
S
E
D
A
L
R
K
A
G
S
A
G
R
A
T
M
F
T
D
V
A
V
-------------
R
G
---------
D
DGVIREHGE--
G
---------
E
V
V
I
K
S
D
-
I
L
L
K
E
Y
W
N
R
P
E
A
T
R
D
A
F
-
D
N
-
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
G
E
I
A
A
A
I
V
V
A
D
--
Q
-
N
E
V
S
--
E
Q
Q
I
V
E
Y
--
C
G
T
R
-
L
A
R
Y
K
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
-
31
HHSearch
81.11
35%
-99
- C4 -
3IPL
-
MENE_STAAN
A:
[1-477]
--
L
D
F
W
-
L
Y
K
Q
A
Q
Q
N
G
H
H
I
A
I
T
D
--
G
Q
E
S
--
Y
T
Y
Q
N
L
Y
C
E
A
S
L
L
A
K
R
L
K
A
Y
---
Q
Q
S
R
V
G
L
Y
I
D
N
S
I
Q
S
I
I
L
I
H
A
C
W
L
A
N
I
E
I
A
M
I
N
T
R
L
T
P
N
E
M
T
N
Q
M
R
S
I
D
V
Q
-------------
L
I
F
C
--------------
T
-------
L
---
P
L
E
L
-------
R
----
G
------------------
F
Q
I
V
-------------
S
----------
L
D
D
----------ES
P
S
-
N
I
--
L
N
T
S
F
N
L
D
D
I
--
A
S
I
M
F
T
S
G
T
T
G
P
Q
K
A
V
P
--
Q
T
F
R
N
H
Y
A
S
A
I
G
C
K
----
E
S
L
G
F
D
--
R
D
T
N
W
L
S
V
L
P
I
Y
H
I
S
G
L
-
S
V
L
L
R
A
V
I
E
--
G
F
T
V
R
I
V
D
K
F
N
A
E
Q
I
L
T
M
I
K
N
E
R
I
--
T
H
I
S
L
V
P
Q
T
L
N
--
W
L
M
Q
Q
G
---
L
---
H
E
--
P
--
Y
-
N
L
Q
K
I
L
L
G
G
A
K
L
-
S
A
T
M
I
E
T
A
L
Q
Y
--
N
L
P
--
I
Y
N
S
F
G
M
T
E
T
C
S
Q
F
L
T
A
-----
T
P
E
M
L
H
A
R
P
D
T
V
G
M
P
S
A
N
V
D
V
K
I
-------------
K
N
---------
P
NKEGH------
G
---------
E
L
M
I
K
G
A
-
N
V
M
N
G
Y
L
Y
P
T
D
L
T
G
T
-
F
-
E
N
-
G
Y
F
N
T
G
D
I
A
E
I
D
H
E
G
Y
V
M
I
Y
D
R
R
K
D
L
I
I
S
G
G
E
N
I
Y
P
Y
Q
I
E
T
V
A
K
Q
F
P
G
I
S
D
A
V
C
V
G
H
P
D
D
T
W
G
Q
V
P
K
L
Y
F
V
S
E
--
S
-
D
-
I
S
--
K
A
Q
L
I
A
Y
--
L
S
K
H
-
L
A
K
Y
K
V
P
K
H
F
E
K
V
D
T
L
P
------------------
3
PsiBlast_PDB
79.31
33%
-96
- C4 -
3IPL
-
MENE_STAAN
A:
[1-477]
--
L
D
F
W
-
L
Y
K
Q
A
Q
Q
N
G
H
H
I
A
I
T
D
--
G
Q
E
S
--
Y
T
Y
Q
N
L
Y
C
E
A
S
L
L
A
K
R
L
K
A
Y
---
Q
Q
S
R
V
G
L
Y
I
D
N
S
I
Q
S
I
I
L
I
H
A
C
W
L
A
N
I
E
I
A
M
I
N
T
R
L
T
P
N
E
M
T
N
Q
M
R
S
I
D
V
Q
L
I
F
C
T
L
P
L
E
L
R
GF
Q
I
V
S
--------------
L
-------
D
---
D
-----------------------------------------------------------------------------
E
S
-
P
S
NI
L
N
T
S
F
N
L
D
D
I
--
A
S
I
M
F
T
S
G
T
T
G
P
Q
K
A
V
P
--
Q
T
F
R
N
H
Y
A
S
A
I
G
C
K
----
E
S
L
G
F
D
--
R
D
T
N
W
L
S
V
L
P
I
Y
H
I
S
G
L
-
S
V
L
L
R
A
V
I
E
--
G
F
T
V
R
I
V
D
K
F
N
A
E
Q
I
L
T
M
I
K
N
E
R
I
--
T
H
I
S
L
V
P
Q
T
L
N
--
W
L
M
Q
-----
Q
--
G
L
H
--
E
--
P
Y
N
L
Q
K
I
L
L
G
G
A
K
L
-
S
A
T
M
I
E
T
A
L
Q
Y
--
N
L
P
--
I
Y
N
S
F
G
M
T
E
T
C
S
Q
F
L
T
A
-----
T
P
E
M
L
H
A
R
P
D
T
V
G
M
P
S
A
N
V
D
V
K
I
-------------
K
N
PNKEG----
H
-----------
G
---------
E
L
M
I
K
G
A
-
N
V
M
N
G
Y
L
Y
P
T
D
L
T
-
G
T
F
-
E
N
-
G
Y
F
N
T
G
D
I
A
E
I
D
H
E
G
Y
V
M
I
Y
D
R
R
K
D
L
I
I
S
G
G
E
N
I
Y
P
Y
Q
I
E
T
V
A
K
Q
F
P
G
I
S
D
A
V
C
V
G
H
P
D
D
T
W
G
Q
V
P
K
L
Y
F
V
S
E
--
S
-
D
-
I
S
--
K
A
Q
L
I
A
Y
--
L
S
K
H
-
L
A
K
Y
K
V
P
K
H
F
E
K
V
D
T
L
P
------------------
14
PsiBlast_PDB
78.20
28%
-98
- C4 -
3DLP
1
?
X:
[4-503]
--
V
N
E
M
-
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
PA
R
G
L
R
--
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
-------------
A
A
V
I
--------------
A
VGRQVAD
A
---
I
F
Q
S
-------
G
----
S
------------------
G
A
R
I
IFLGDLVRDGEPY
S
----------
Y
G
P
P
I
E
----
D
P
Q
--
R
E
-
P
----------
A
Q
P
--
A
F
I
F
Y
T
S
G
T
T
G
L
P
K
A
A
I
IP
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
----
V
G
L
R
H
G
--
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
V
L
V
A
A
L
A
LD
G
T
Y
V
V
V
E
E
-
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
--
T
S
L
F
A
T
P
T
H
L
D
--
A
L
A
A
A
A
AHA
G
--
S
S
L
--
K
L-
D
-
S
L
R
H
V
T
F
A
G
A
T
M
-
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
-----
Q
P
K
-----
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIGGGVDEIVAN
G
E
---------
E
-----------
G
---------
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
P
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
LG
E
-
T
-
L
S
--
A
D
A
L
D
T
F
--
C
R
S
S
E
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-
12
PsiBlast_PDB
77.95
28%
-96
- C4 -
3CW9
5
?
A:
[4-503]
--
V
N
E
M
-
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
PA
R
G
L
R
--
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
-------------
A
A
V
I
--------------
A
VGR
Q
V
A
D
A
---
I
F
Q
S
-------
G
----
S
------------------
G
A
R
I
I
F
LGDLVRDGEPY
S
----------
Y
G
P
P
I
E
----
D
P
Q
--
R
E
-
P
----------
A
Q
P
--
A
F
I
F
Y
T
S
G
T
T
G
L
P
K
A
A
I
I
P
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
----
V
G
L
R
H
G
--
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
V
L
V
A
A
L
A
L
D
G
T
Y
V
V
V
E
E
-
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
--
T
S
L
F
A
T
P
T
H
L
D
--
A
L
A
A
A
A
A
H
A
G
--
S
S
L
--
K
L-
D
-
S
L
R
H
V
T
F
A
G
A
T
M
-
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
G
E
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
-----
Q
P
K
-----
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
V
RIGGGVDEIVAN
G
E
---------
E
-----------
G
---------
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
LG
E
-
T
-
L
S
--
A
D
A
L
D
T
F
--
C
R
S
S
E
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-
13
PsiBlast_PDB
77.74
28%
-97
- C4 -
3CW8
5
?
X:
[4-502]
--
V
N
E
M
-
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
PA
R
G
L
R
--
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
-------------
A
A
V
I
--------------
A
VGRQVAD
A
---
I
F
Q
S
-------
G
----
S
------------------
G
A
R
I
IFLGDLVRDGEPY
S
----------
Y
G
P
P
I
E
----
D
P
Q
--
R
E
-
P
----------
A
Q
P
--
A
F
I
F
Y
T
S
G
T
T
G
L
P
K
A
A
I
IP
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
----
V
G
L
R
H
G
--
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
V
L
V
A
A
L
A
LD
G
T
Y
V
V
I
E
E
-
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
--
T
S
L
F
A
T
P
T
H
L
D
--
A
L
A
A
A
A
AHA
G
--
S
S
L
--
K
L-
D
-
S
L
R
H
V
T
F
A
G
A
T
M
-
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
-----
Q
P
K
-----
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIGGGVDEIVAN
G
E
---------
E
-----------
G
---------
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
E
A
T
A
E
K
L
-
Q
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
-
W
G
Q
S
V
T
A
C
V
V
P
R
LG
E
-
T
-
L
S
--
A
D
A
L
D
T
F
--
C
R
S
S
E
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
--
20
PsiBlast_PDB
77.27
29%
-88
- C4 -
3A9V
1
?
A:
[47-532]
--------------------------
G
D
V
--
Y
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
-------------
L
L
I
T
--------------
Q
-------
A
---
C
Y
Y
E
-------
K
----
V
K
D
F
A
R
E
S
D
V
K
V
M
C
VDSAP
D
G
C
L
-------------
H
----------
F
S
E
L
T
Q
----
A
D
E
--
N
E
A
P
Q
--
V
D
I
S
P
D
--
D
V
--
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
--
L
T
H
K
G
L
I
T
S
V
A
Q
Q
V
DGDN
P
N
L
Y
F
H
--
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
A
L
N
S
I
M
L
C
G
L
R
V
--
G
A
P
I
L
I
M
P
K
F
E
I
G
S
L
L
G
L
I
E
K
Y
K
V
--
S
I
A
P
V
V
P
P
V
M
M
--
S
I
A
K
S
P
---
D
--
L
D
K
--
H
DL
S
-
S
L
R
M
I
K
S
G
G
A
P
L
-
G
K
E
L
E
D
T
V
R
A
K
F
P
Q
A
R
--
L
G
Q
G
Y
G
M
T
E
A
G
P
V
L
A
M
C
LAFAK
E
P
F
D
I
--
K
P
G
A
C
G
T
V
V
R
N
A
E
M
K
I
-------------
V
D
---------
P
ETG
A
S
L
P
R
NQP
G
---------
E
I
C
I
R
G
D
-
Q
I
M
K
G
Y
L
N
D
P
E
A
T
S
R
T
I
D
K
E
-
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
--
E
-
K
-
S
Q
AT
E
D
E
I
K
Q
Y
--
I
S
K
Q
-
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
---
11
PsiBlast_PDB
76.72
28%
-100
- C4 -
1T5D
2
?
X:
[4-503]
--
V
N
E
M
-
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
PA
R
G
L
R
--
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
-------------
A
A
V
I
--------------
A
VGRQVAD
A
---
I
F
Q
S
-------
G
----
S
------------------
G
A
R
I
IFLGDLVRDGEPY
S
----------
Y
G
P
P
I
E
----
D
P
Q
--
R
E
-
P
----------
A
Q
P
--
A
F
I
F
Y
T
S
--
T
G
L
P
K
A
A
I
IP
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
----
V
G
L
R
H
G
--
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
V
L
V
A
A
L
A
LD
G
T
Y
V
V
V
E
E
-
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
--
T
S
L
F
A
T
P
T
H
L
D
--
A
L
A
A
A
A
AHA
G
--
S
S
L
--
K
L-
D
-
S
L
R
H
V
T
F
A
G
A
T
M
-
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
-----
Q
P
K
-----
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIGGGVDEIVAN
G
E
---------
E
-----------
G
---------
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
LG
E
-
T
-
L
S
--
A
D
A
L
D
T
F
--
C
R
S
S
E
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-
8
PsiBlast_PDB
76.64
28%
-98
- C4 -
2QW0
1
?
X:
[4-503]
--
V
N
E
M
-
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
PA
R
G
L
R
--
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
-------------
A
A
V
I
--------------
A
VQVAD--
A
---
I
F
Q
S
-------
G
----
S
------------------
G
A
R
I
IFLGDLVRDGEPY
S
----------
Y
G
P
P
I
E
----
D
P
Q
--
R
E
-
P
----------
A
Q
P
--
A
F
I
F
Y
T
S
---
G
L
P
K
A
A
I
IP
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
----
V
G
L
R
H
G
--
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
V
L
V
A
A
L
A
LD
G
T
Y
V
V
V
E
E
-
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
--
T
S
L
F
A
T
P
T
H
L
D
--
A
L
A
A
A
A
AHA
G
--
S
S
L
--
K
L-
D
-
S
L
R
H
V
T
F
A
G
A
T
M
-
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
A
Y
G
T
T
E
A
M
N
S
L
Y
M
R
-----
Q
P
K
-----
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIGGGVDEIVAN
G
E
---------
E
-----------
G
---------
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
LG
E
-
T
-
L
S
--
A
D
A
L
D
T
F
--
C
R
S
S
E
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-
19
PsiBlast_PDB
76.50
29%
-94
- C4 -
3A9U
-
?
A:
[47-532]
--------------------------
G
D
V
--
Y
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
-------------
L
L
I
T
--------------
Q
-------
A
---
C
Y
Y
E
-------
K
----
V
K
D
F
A
R
ED
V
K
V
M
C
VDSAP-
D
G
C
L
-------------
H
----------
F
S
E
L
T
Q
----
A
D
E
--
N
E
A
P
Q
--
V
D
I
S
P
D
--
D
V
--
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
--
L
T
H
K
G
L
I
T
S
V
A
Q
Q
V
DGDN
P
N
L
Y
F
H
--
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
A
L
N
S
I
M
L
C
G
L
R
V
--
G
A
P
I
L
I
M
P
K
F
E
I
G
S
L
L
G
L
I
E
K
Y
K
V
--
S
I
A
P
V
V
P
P
V
M
M
--
S
I
A
K
S
P
---
D
--
L
D
K
--
H
DL
S
-
S
L
R
M
I
K
S
--------
E
L
E
D
T
V
R
A
K
F
P
Q
A
R
--
L
G
Q
G
Y
G
M
T
E
A
G
P
V
L
A
M
C
LAFAK
E
P
F
D
I
--
K
P
G
A
C
G
T
V
V
R
N
A
E
M
K
I
-------------
V
D
---------
P
ETG
A
S
L
P
R
NQP
G
---------
E
I
C
I
R
G
D
-
Q
I
M
K
G
Y
L
N
D
P
E
A
T
S
R
T
I
D
K
E
-
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
F
V
V
K
S
--
E
-
K
-
S
Q
AT
E
D
E
I
K
Q
Y
--
I
S
K
Q
-
V
I
F
Y
K
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
---
9
PsiBlast_PDB
76.43
28%
-95
- C4 -
2QVX
1
?
X:
[4-502]
--
V
N
E
M
-
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
PA
R
G
L
R
--
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
-------------
A
A
V
I
--------------
A
VGRQVAD
A
---
I
F
Q
S
-------
G
----
S
------------------
G
A
R
I
IFLGDLVRDGEPY
S
----------
Y
G
P
P
I
E
----
D
P
Q
--
R
E
-
P
----------
A
Q
P
--
A
F
I
F
Y
T
S
--
T
G
L
P
K
A
A
I
IP
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
----
V
G
L
R
H
G
--
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
V
L
V
A
A
L
A
LD
G
T
Y
V
V
V
E
E
-
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
--
T
S
L
F
A
T
P
T
H
L
D
--
A
L
A
A
A
A
AHA
G
--
S
S
L
--
K
L-
D
-
S
L
R
H
V
T
F
A
G
A
T
M
-
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
G
Y
G
T
T
E
A
M
N
S
L
Y
M
R
-----
Q
P
K
-----
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIGGGVDEIVAN
G
E
---------
E
-----------
G
---------
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
LG
E
-
T
-
L
S
--
A
D
A
L
D
T
F
--
C
R
S
S
E
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
--
7
PsiBlast_PDB
76.32
28%
-98
- C4 -
2QVZ
1
?
X:
[4-503]
--
V
N
E
M
-
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
PA
R
G
L
R
--
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
-------------
A
A
V
I
--------------
A
VQVAD--
A
---
I
F
Q
S
-------
G
----
S
------------------
G
A
R
I
IFLGDLVRDGEPY
S
----------
Y
G
P
P
I
E
----
D
P
Q
--
R
E
-
P
----------
A
Q
P
--
A
F
I
F
Y
T
S
---
G
L
P
K
A
A
I
IP
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
----
V
G
L
R
H
G
--
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
V
L
V
A
A
L
A
LD
G
T
Y
V
V
V
E
E
-
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
--
T
S
L
F
A
T
P
T
H
L
D
--
A
L
A
A
A
A
AHA
G
--
S
S
L
--
K
L-
D
-
S
L
R
H
V
T
F
A
G
A
T
M
-
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
A
Y
G
T
T
E
A
M
N
S
L
Y
M
R
-----
Q
P
K
-----
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIGGGVDEIVAN
G
E
---------
E
-----------
G
---------
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
LG
E
-
T
-
L
S
--
A
D
A
L
D
T
F
--
C
R
S
S
E
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-
15
PsiBlast_PDB
75.44
29%
-91
- C4 -
4FUQ
7
?
A:
[26-498]
--------------------------
G
D
K
--
I
S
Y
A
E
L
V
A
R
A
G
R
V
A
N
V
L
V
A
R
G
L
Q
V
G
D
R
V
A
A
Q
T
E
K
S
V
E
A
L
V
L
Y
L
A
T
V
R
A
G
G
V
Y
L
P
L
N
T
A
Y
T
L
H
E
L
D
Y
F
I
T
D
A
E
P
K
-------------
I
V
V
C
--------------
D
-------
P
---
S
K
R
D
GI
A
A
I
A
A
K
----
V
------------------
G
A
T
V
E
T
L
G
PD-------
G
----------
R
G
S
L
T
D
----
A
A
A
--
G
A
-
S
E
--
A
F
A
T
I
D
R
G
A
D
DL
A
A
I
L
Y
T
S
--
T
G
R
S
K
G
A
M
--
L
S
H
D
N
L
A
S
N
S
L
T
L
V
----
D
Y
W
R
F
T
--
P
D
D
V
L
I
H
A
L
P
I
Y
H
T
H
G
L
-
F
V
A
S
N
V
T
L
F
A
R
G
S
M
I
F
L
P
K
-
F
D
P
D
K
I
L
D
L
M
A
R
A
T
V
L
M
G
V
P
T
F
Y
T
R
L
L
Q
SP
R
L
T
K
E
T
---
T
--
G
---------
H
M
R
L
F
I
S
G
S
A
P
L
L
A
D
T
H
R
E
W
S
A
K
T
--
G
H
A
--
V
L
E
R
Y
G
M
T
E
T
N
M
N
--
T
S
-----
N
P
Y
D
G
D
R
V
P
G
A
V
G
P
A
L
P
G
V
S
A
R
V
-------------
T
D
---------
P
ETGKELPRGDI
G
---------
M
I
E
V
K
G
P
-
N
V
F
K
G
Y
W
R
M
P
E
K
T
K
S
E
F
-
R
D
D
G
F
F
I
T
G
D
L
G
K
I
D
E
R
G
Y
V
H
I
L
G
R
G
K
D
L
V
I
T
G
G
F
N
V
Y
P
K
E
I
E
S
E
I
D
A
M
P
G
V
V
E
S
A
V
I
G
V
P
H
A
D
F
G
E
G
V
T
A
V
V
V
R
D
--
K
-
G
-
A
T
--
I
D
E
A
Q
V
L
H
G
L
D
G
Q
-
L
A
K
F
K
M
P
K
K
V
I
F
V
D
D
L
P
R
N
T
M
G
K
V
Q
K
N
V
L
R
E
T
Y
--
16
PsiBlast_PDB
75.30
29%
-98
- C4 -
1T5H
1
?
X:
[8-503]
-------
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
PA
R
G
L
R
--
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
-------------
A
A
V
I
--------------
A
VQVAD--
A
---
I
F
Q
S
-------
G
----
S
------------------
G
A
R
I
IFLGDLVRDGEPY
S
----------
Y
G
P
P
I
E
----
D
P
Q
--
R
E
-
P
----------
A
Q
P
--
A
F
I
F
Y
T
S
---
G
L
P
K
A
A
I
--
I
P
Q
R
A
A
E
S
R
V
L
F
M
S
----
T
Q
V
G
L
R
HG
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
V
L
V
A
A
L
A
LD
G
T
Y
V
V
V
E
E
-
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
--
T
S
L
F
A
T
P
T
H
L
D
--
A
L
A
A
A
A
AHA
G
--
S
S
L
--
K
L-
D
-
S
L
R
H
V
T
F
A
G
A
T
M
-
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
-----
Q
P
K
-----
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIGGGVDEIVAN
G
E
---------
E
-----------
G
---------
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
LG
E
-
T
-
L
S
--
A
D
A
L
D
T
F
--
C
R
S
S
E
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-
10
PsiBlast_PDB
74.92
28%
-95
- C4 -
2QVY
1
?
X:
[4-503]
--
V
N
E
M
-
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
PA
R
G
L
R
--
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
-------------
A
A
V
I
--------------
A
VQVAD--
A
---
I
F
Q
S
-------
G
----
S
------------------
G
A
R
I
IFLGDLVRDGEPY
S
----------
Y
G
P
P
I
E
----
D
P
Q
--
R
E
-
P
----------
A
Q
P
--
A
F
I
F
Y
T
S
--
T
G
L
P
K
A
A
I
IP
Q
R
A
A
E
S
R
V
L
F
M
S
T
Q
----
V
G
L
R
H
G
--
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
A
V
L
V
A
A
L
A
LD
G
T
Y
V
V
V
E
E
-
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
--
T
S
L
F
A
T
P
T
H
L
D
--
A
L
A
A
A
A
AHA
G
--
S
S
L
--
K
L-
D
-
S
L
R
H
V
T
F
A
G
A
T
M
-
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
G
Y
G
T
T
E
A
M
N
S
L
Y
M
R
-----
Q
P
K
-----
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIGGGVDEIVAN
G
E
---------
E
-----------
G
---------
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
LG
E
-
T
-
L
S
--
A
D
A
L
D
T
F
--
C
R
S
S
E
L
A
D
F
K
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-