@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1679: (2016-03-27 )
VAKEYAQDTAVIKASLGIDKETGALNTPIHLSSTFHQHDFDNYHAYDYARSGNPTREKVEQAIAELEGGTNGFAFASGMAAVSAALFTLSKGDHFIIAKDVYGGTFRLVEQVLPRFGITHTFVDTTNIDEVAKAFQANTKLVYLETPSNPLLHVTDIRTVAKLAKANGCYTFVDNTFLTPLIQKPLELGADLVIHSATKFLGGHSDILAGLIVTNNPNLAEAVYFLQNSTGGVLGVQDSWLLLRGLKTLSVRMKAGTETAEKIALFLNAEPDVVAVHYPGLPSHAGYDIQVEQATSGGAVLSFDLGSEEAVRELVTHLELPVFSVSLGAVESILSYPAKMSHAAVPEEERLAQGITPGLLRFSAGLEDAEDLIADLKQALSFIKKGSVAK
Atome Classification :
(28 SA)
.........10.......------.20........30........40--------.--------..-----------.....50........60........70........80.......-.90-........100.......110....-...120....-...130.......140.......150.......160..-..-.-..170.......180-.......190.......200.......-210........220-----.-.--------------------------..--..--..230.......240.......250.......260.......270.......280.......290..-.....300...-...-.310.......320.....---..330.......340.......350.......360.......370.......380.......390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
VA
K
E
YAQD
T
A
V
I
K
A
SLGI------DKETGALNT
P
I
H
LSSTFHQHDFD--------N--------YH-----------AYDYARSGNP
T
R
E
K
V
E
Q
A
I
A
E
LEGGTNG
F
A
F
A
S
G
M
A
A
V
S
A
A
L
F
T-LSK-GD
H
F
I
I
A
K
DVYG
G
T
F
R
L
V
E
Q
V
L
P
RF-G
I
T
H
T
FVDTT-
N
I
D
E
V
A
K
A
F
QAN
T
K
L
V
Y
L
ETPSN
P
L
L
H
V
T
D
I
R
T
V
A
K
L
A-KA-N-G
C
Y
T
FVD
N
T
F
L
T
P
L
I
-
Q
K
P
L
E
LGA
D
L
V
I
H
S
A
T
K
FLGG
H
S
D
I
L
A
-
G
L
-
I
VTNNP
N
L
A
E
------
A
-
V
--------------------------
Y
F
--
L
Q--NSTG
G
V
LGVQ
D
S
W
L
L
L
RGLK
T
L
S
V
R
MKAGTE
T
A
E
K
I
A
L
F
L
NAEP
D
V
V
A
V
HYPGLPSHA
G
Y
D
I
Q
V
E
QA-TSG
G
A
V
L
S
F
DL-G
S
E
-
E
A
V
R
E
L
V
T
H
LEL
P
V
F
S
V
S
L
---
G
A
V
E
S
I
L
SY
P
A
KMSHAAV
P
E
E
E
R
L
A
QGIT
P
G
L
L
R
F
SAGLE
D
A
E
D
L
I
A
D
L
K
Q
A
L
S
F
I
KKGSVAK
1
PsiBlast_PDB
87.68
49%
-98
- C1 -
4L0O
2
METB_HELPY
H:
[5-379]
--------
T
K
L
I
H
G
G
I
S
E
------
D
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
---------------------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
V
F
S
L
-
L
Q
S
-
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
-
V
T
T
N
N
E
A
L
A
Q
------
E
-
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
-
K
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
---
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-------
10
PsiBlast_PDB
86.99
42%
-98
- C1 -
3JWA
6
?
A:
[5-393]
--
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
------
D
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
---
V
F
D
--------
S
--------
A
E
Q
G
A
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
-
I
V
G
K
Q
E
F
I
D
Q
------
A
-
R
--------------------------
F
V
G-
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
---
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
----------
26
PsiBlast_CBE
86.79
49%
-100
- C1 -
4L0O
2
METB_HELPY
C:
[5-379]
--------
T
K
L
I
H
G
G
I
S
E
------
D
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
G
------------------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
V
F
S
L
-
L
Q
S
-
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
-
V
T
T
N
N
E
A
L
A
Q
------
E
-
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
-
K
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
---
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
----------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-------
11
PsiBlast_PDB
86.79
42%
-98
- C1 -
3JWB
4
?
A:
[5-393]
--
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
------
D
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
---
V
F
D
--------
S
--------
A
E
Q
G
A
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
-
I
V
G
K
Q
E
F
I
D
Q
------
A
-
R
--------------------------
F
V
G-
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
---
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
----------
7
PsiBlast_PDB
86.63
42%
-98
- C1 -
4HF8
5
?
A:
[5-393]
--
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
------
D
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
---
V
F
D
--------
S
--------
A
E
Q
G
A
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
-
I
V
G
K
Q
E
F
I
D
Q
------
A
-
R
--------------------------
F
V
G-
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
---
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
----------
3
PsiBlast_PDB
86.54
42%
-99
- C1 -
4OMA
6
?
A:
[4-393]
-
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
------
D
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
---
V
F
D
--------
S
--------
A
E
Q
G
A
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
-
I
V
G
K
Q
E
F
I
D
Q
------
A
-
R
--------------------------
F
V
G-
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
---
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
----------
9
PsiBlast_PDB
86.31
41%
-98
- C1 -
3JW9
2
?
A:
[4-393]
-
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
------
D
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
---
V
F
D
--------
S
--------
A
E
Q
G
A
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
-
I
V
G
K
Q
E
F
I
D
Q
------
A
-
R
--------------------------
F
V
G-
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
---
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
----------
37
PsiBlast_CBE
85.57
42%
-96
- C1 -
1E5E
6
?
B:
[10-392]
--------
T
A
C
I
H
A
N
P
Q
K
------
D
-
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
---
V
F
D
--------
N
--------
C
Q
QGGNRFAGQES
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
-
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
-
I
C
-
G
K
A
D
L
L
Q
------
Q
-
I
--------------------------
R
M
VG
I
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
-
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
---
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
----------
24
PsiBlast_CBE
85.56
49%
-98
- C1 -
4L0O
1
METB_HELPY
G:
[5-379]
--------
T
K
L
I
H
G
G
I
S
E
------
D
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
G
-------------------------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
V
F
S
L
-
L
Q
S
-
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
-
V
T
T
N
N
E
A
L
A
Q
------
E
-
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
-
K
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
---
G
G
V
E
S
L
V
G
I
P
A
F
M
T
----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-------
22
PsiBlast_CBE
85.45
49%
-102
- C1 -
4L0O
2
METB_HELPY
M:
[5-379]
--------
T
K
L
I
H
G
G
I
S
E
------
D
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
G
------------------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
V
F
S
L
-
L
Q
S
-
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
-
V
T
T
N
N
E
A
L
A
Q
------
E
-
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
-
K
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
---
G
G
V
E
S
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-------
12
PsiBlast_PDB
85.08
42%
-100
- C1 -
2RFV
1
?
A:
[5-393]
--
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
------
D
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
---
V
F
D
--------
S
--------
A
E
Q
G
A
A
R
F-----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
-
I
V
G
K
Q
E
F
I
D
Q
------
A
-
R
--------------------------
F
V
G-
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
---
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
----------
118
HHSearch
84.77
42%
-101
- C1 -
2RFV
1
?
A:
[5-397]
--
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
------
D
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
--------
Q
G
A
A
R
F----------------
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
-
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
R
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
-
D
V
I
G
G
I
-
I
V
G
K
Q
-
E
F
I
D
------
Q
-
A
--------------------------
R
F
VG
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
-
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
---
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
------
23
PsiBlast_CBE
84.67
49%
-97
- C1 -
4L0O
1
METB_HELPY
K:
[5-379]
--------
T
K
L
I
H
G
G
I
S
E
------
D
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
G
--------
R
--------
H
------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
V
F
S
L
-
L
Q
S
-
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
-
V
T
T
N
N
E
A
L
A
Q
------
E
-
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
-
K
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
---
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-------
18
PsiBlast_PDB
84.43
42%
-94
- C1 -
1E5F
6
?
A:
[10-392]
--------
T
A
C
I
H
A
N
P
Q
K
------
D
-
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
---
V
F
D
--------
N
--------
C
Q
Q
G
G
N
R
F
A
GQ
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
-
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
-
I
C
-
G
K
A
D
L
L
Q
------
Q
-
I
--------------------------
R
M
VG
I
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
-
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
---
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
----------
36
PsiBlast_CBE
84.36
42%
-96
- C1 -
1E5F
5
?
B:
[10-392]
--------
T
A
C
I
H
A
N
P
Q
K
------
D
-
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
---
V
F
D
--------
N
--------
C
Q
QGGNRFAGQES
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
-
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
-
I
C
-
G
K
A
D
L
L
Q
------
Q
-
I
--------------------------
R
M
VG
I
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
-
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
---
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
----------
25
PsiBlast_CBE
84.28
49%
-100
- C1 -
4L0O
2
METB_HELPY
E:
[5-379]
--------
T
K
L
I
H
G
G
I
S
E
------
D
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
G
-------------------------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
V
F
S
L
-
L
Q
S
-
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
-
V
T
T
N
N
E
A
L
A
Q
------
E
-
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
-
K
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
---
G
G
V
E
S
L
V
G
I
P
A
F
M
-----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-------
21
PsiBlast_CBE
84.09
49%
-100
- C1 -
4L0O
2
METB_HELPY
O:
[5-379]
--------
T
K
L
I
H
G
G
I
S
E
------
D
A
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
G
--------
R
--------
H
K
-----------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
A
V
F
S
L
-
L
Q
S
-
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
-
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
-
V
T
T
N
N
E
A
L
A
Q
------
E
-
I
--------------------------
A
F
--
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
-
R
G
F
S
G
M
L
S
F
T
L
-
K
N
D
-
S
E
A
V
A
F
V
E
S
L
K
L
F
I
L
G
E
S
L
---
G
G
V
E
S
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-------
17
PsiBlast_PDB
83.94
42%
-94
- C1 -
1E5E
5
?
A:
[10-392]
--------
T
A
C
I
H
A
N
P
Q
K
------
D
-
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
---
V
F
D
--------
N
--------
C
Q
Q
G
G
N
R
F
A
GQ
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
-
H
S
-
Q
E
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
-
I
C
-
G
K
A
D
L
L
Q
------
Q
-
I
--------------------------
R
M
VG
I
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
-
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
---
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
----------
65
PsiBlast_CBE
83.06
42%
-101
- C1 -
1PG8
5
MEGL_PSEPU
C:
[59-394]
--------------------------------------------------------------------------------
Y
S
R
I
S
N
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
G
E
A
G
L
A
L
A
S
G
M
G
A
I
T
S
T
L
W
T
-
L
L
R
P
G
D
E
V
L
L
G
N
T
L
Y
G
C
T
F
A
F
L
H
H
G
I
G
E
F
-
G
V
K
L
R
H
V
D
M
A
-
D
L
Q
A
L
E
A
A
M
T
P
A
T
R
V
I
Y
F
E
S
P
A
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
-
R
K
-
H
-
G
A
T
V
V
V
D
N
T
Y
C
T
P
Y
L
-
Q
R
P
L
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
G
H
G
D
I
T
A
-
G
I
-
V
V
G
S
Q
-
A
L
V
D
------
R
-
I
--------------------------
R
L
QG
L
K
--
D
M
T
G
A
V
L
S
P
H
D
A
A
L
L
M
R
G
I
K
T
L
N
L
R
M
D
R
H
C
A
N
A
Q
V
L
A
E
F
L
A
R
Q
P
Q
V
E
L
I
H
Y
P
G
L
A
S
F
P
Q
Y
T
L
A
R
Q
Q
M
-
S
Q
P
G
G
M
I
A
F
E
L
K
G
G
I
-
G
A
G
R
R
F
M
N
A
L
Q
L
F
S
R
A
V
S
L
---
G
D
A
E
S
L
A
Q
H
P
A
S
M
T
H
S
S
Y
T
P
E
E
R
A
H
Y
G
I
S
E
G
L
V
R
L
S
V
G
L
E
D
I
D
D
L
L
A
D
V
Q
Q
A
L
----------
29
PsiBlast_CBE
82.99
45%
-94
- C1 -
4IY7
5
?
D:
[14-393]
---------
A
L
S
L
A
T
L
A
I
HGGQSP
D
P
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
G
--------
E
--------
H
Q
-----------
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
V
M
E
L
-
L
D
A
-
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
-
R
K
-
H
-
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
N
A
E
L
A
E
------
Q
-
M
--------------------------
A
F
--
L
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
-
S
G
F
G
G
I
V
S
I
V
L
K
G
G
F
-
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
---
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
----------
8
PsiBlast_PDB
82.83
42%
-99
- C1 -
3MKJ
1
?
A:
[5-393]
--
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
------
D
P
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
---
V
F
D
--------
S
--------
A
E
Q
G
A
A
R
F-----------
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
-
I
V
G
K
Q
E
F
I
D
Q
------
A
-
R
--------------------------
F
V
G-
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
-
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
-
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
---
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
----------
115
HHSearch
81.43
42%
-91
- C1 -
1E5E
5
?
A:
[4-397]
--
E
R
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
------
D
-
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
--------
E
S
-----------
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
-
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
-
H
S
Q
E
-
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
-
I
C
G
K
A
-
D
L
L
Q
------
Q
-
I
--------------------------
R
M
--
V
G
IK
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
-
R
M
Y
G
S
M
I
T
F
I
L
-
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
---
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
R
-----
89
PsiBlast_CBE
81.15
40%
-110
- C1 -
1PFF
17
?
A:
[3-330]
-------------------------------------------------------------------------------------------
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
V
W
T
F
L
K
A
-
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
-
G
V
E
V
D
F
I
D
M
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
Q
-
K
-
D
I
L
V
I
V
D
N
T
F
A
S
P
I
L
-
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
-
V
C
S
R
A
D
I
I
A
K
------
V
K
S
--------------------------
Q
G
--
I
K
--
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
M
-
K
M
F
G
S
M
I
A
F
D
V
-
D
G
L
-
E
K
A
K
K
V
L
D
N
C
H
V
V
S
L
A
V
S
L
---
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V
-------
125
HHSearch
80.67
40%
-107
* C1 *
1PFF
18
?
A:
[2-330]
------------------------------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
V
W
T
F
L
K
A
-
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
-
G
V
E
V
D
F
I
D
M
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
-
R
K
Q
K
-
D
I
L
V
I
V
D
N
T
F
A
S
P
I
L
-
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
-
V
C
S
R
A
-
D
I
I
A
------
K
-
V
--------------------------
K
S
--
Q
G
IK
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
M
-
K
M
F
G
S
M
I
A
F
D
V
-
D
G
L
-
E
K
A
K
K
V
L
D
---
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V
-------
28
PsiBlast_CBE
79.41
45%
-102
- C1 -
1IBJ
3
METC_ARATH
C:
[103-459]
-----------------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
I
--------
E
--------
N
G
-----------
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
V
T
H
L
-
I
K
N
-
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
-
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
-
H
A
-
Q
-
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
-
L
A
V
K
G
E
K
L
A
K
------
E
-
V
--------------------------
Y
F
--
L
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
-
G
S
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
---
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
----------
113
HHSearch
78.68
44%
-98
- C1 -
1IBJ
4
METC_ARATH
A:
[85-462]
----
A
S
V
S
T
L
L
V
N
L
D
N
K
F
------
D
-
P
F
D
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
I
--------
E
--------
N
G
-----------
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
V
T
H
L
-
I
K
N
-
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
-
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
-
H
A
-
Q
-
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
-
L
A
V
K
G
E
K
L
A
K
------
E
-
V
--------------------------
Y
F
--
L
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
-
G
S
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
---
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
-------
2
PsiBlast_PDB
78.38
45%
-102
- C1 -
1IBJ
4
METC_ARATH
A:
[103-459]
-----------------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
I
--------
E
--------
N
G
-----------
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
V
T
H
L
-
I
K
N
-
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
-
G
V
V
V
K
R
V
N
T
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
-
H
A
-
Q
-
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
-
L
A
V
K
G
E
K
L
A
K
------
E
-
V
--------------------------
Y
F
--
L
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
-
K
G
A
G
S
V
F
S
F
I
T
-
G
S
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
---
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
----------
120
HHSearch
64.91
33%
-86
- C1 -
2CTZ
1
?
A:
[2-421]
-----
R
F
E
T
L
Q
L
H
A
G
Y
E
P
------
E
P
T
T
L
S
R
Q
V
P
I
Y
P
T
T
S
Y
V
F
K
S
P
E
--------
H
A
A
N
L
F
A
LK
E
F
-----------
G
N
I
Y
S
R
I
M
N
P
T
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
T
A
S
G
H
A
A
Q
F
L
A
L
T
T
L
A
Q
A
-
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
L
-
G
I
E
V
R
F
T
S
R
E
E
R
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
L
A
Q
A
A
-
R
E
-
K
-
G
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
G
H
G
A
V
I
A
-
G
A
-
I
V
D
G
G
-
N
F
P
W
EGGRYP
L
-
L
TEPQPGYHGLRLTEAFGEL
A
F
I
V
K
A
R
V
D
--
G
L
--
R
D
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
H
H
P
H
H
D
R
A
Q
K
Y
F
K
G
K
P
G
A
V
L
T
F
G
L
-
K
G
G
Y
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
---
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
A
---------