@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1680: (2016-03-27 )
MAKLKQETIAAQIGNRKCERTGAVNMPVYFSTAYQHADLGVSTGYDYTRTGNPTRDALQEALAELENGTHAFATSSGMSAIQLVFQLFKTGEHIISSQDLYGGTFRYFEQFGAQYQIGFSYWDGAEIADLEKLIRPETKAIFIETPTNPLMQETDIATVAKWAHAHDLLVIVDNTFYTPVLQQPLSLGADIVIHSATKYLGGHNDVLAGAVIVKEEKLGKFFFDQLNATGTVLSPFDSWLLIRGLKTLVLRVRQHQANAQKIAAFLEEHKLVEEVRYPGRGGMISFFIRDAALVSPLLKELELFTFAESLGGVESLITYPTTQTHADIPVELRNSYGLTDKLLRISVGIEASEDLIADLSKALDAVLEEVSARG
Atome Classification :
(34 SA)
.........10........-20........------30.--..-....--.40-------.--------.------.......50........60........70........80.-.-...-...90........100.......110....-...120..--.-....130.......140.......150.......160...-.-.-..170.......180-.......190.......200......-.210...--....220----..--------------------------...--.--...230.......240.......250.......260.......270.....----------------.----------------.-----------------280--------------.--........---290.-...-.-...300.......---310.......320.......330.......340.......350.......360.......370..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAK
L
K
Q
E
T
I
A
A
Q
IGNRKCE-RTGAVNM
P
V
Y
------
F
S
T--AY-QHAD--LG--------V--------S------TGYDYTRTGNP
T
R
D
A
L
Q
E
A
L
A
E
L
ENG
T
H
A
FATSS
G
M
S
A
I
Q
-
L
-
V
F
Q
-
L
F
KT
G
E
H
I
ISSQDLY
G
G
T
F
R
Y
F
E
Q
FGA
Q
Y
Q
-
I
G
F
SYWDG--
A
-
E
I
A
D
L
E
K
L
IRPET
K
A
I
F
I
ETPTNPLMQET
D
I
A
T
V
A
K
W
AHA-
H
-
D
-
L
L
V
I
VDNTFY
T
P
V
L
Q
-
Q
P
L
SLGA
D
I
V
I
H
S
A
T
K
YLGGHND
V
L
A
-
G
A
V
I
V
K
E
--
E
K
L
G
K
------
F
F
--------------------------
F
D
Q--L--NATGTVLS
P
F
D
S
W
L
L
I
R
G
L
K
T
L
V
L
R
V
R
Q
HQA
N
A
Q
K
I
A
A
F
L
E
E
H
K
L
V
E
E
VRY----------------P----------------G-----------------R----------------G--
G
M
I
S
F
F
I
R
---
D
A
-
A
-
L
V
S
-
P
-
L
L
K
E
L
E
L
F
T
F
A
E
S
---LG
G
V
E
S
L
ITYPTTQTHADI
P
V
E
LRNSYGL
T
D
K
L
L
R
I
S
VGIE
A
S
E
D
L
I
A
D
L
S
K
A
L
D
A
V
L
E
E
V
SARG
29
PsiBlast_CBE
91.56
45%
-97
- C1 -
4IY7
4
?
C:
[15-393]
---
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
------
A
T
S
--
T
Y
-
A
Q
S
S
--
P
G
--------
E
--------
H
------
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
-
H
-
G
-
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
NA
E
L
A
E
Q
------
M
A
--------------------------
F
L
Q
-----
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
----------------
P
----------------
G
-----------------
L
ASHPQHVLAKRQMSGF
G
--
G
I
V
S
I
V
L
K
GGF
D
A
-
A
---
K
-
R
-
F
C
E
K
T
E
L
F
T
L
A
E
S
---
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-----------
2
PsiBlast_PDB
91.09
45%
-95
- C1 -
4IY7
8
?
A:
[15-393]
---
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
------
A
T
S
--
T
Y
-
A
Q
S
S
--
P
G
--------
E
--------
H
------
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
-
H
-
G
-
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
N
A
E
L
A
E
Q
------
M
A
--------------------------
F
L
Q
-----
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
----------------
P
----------------
G
-----------------
L
ASHPQ
H
V
L
A
K
R
Q
M
SGF
G
--
G
I
V
S
I
V
L
K
GG
F
D
A
-
A
---
K
-
R
-
F
C
E
K
T
E
L
F
T
L
A
E
S
---
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-----------
30
PsiBlast_CBE
90.99
45%
-96
- C1 -
4IY7
6
?
B:
[15-393]
---
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
------
A
T
S
--
T
Y
-
A
Q
S
S
--
P
G
--------
E
--------
H
------
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
-
H
-
G
-
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
NA
E
L
A
E
Q
------
M
A
--------------------------
F
L
Q
-----
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
----------------
P
----------------
G
-----------------
L
ASHPQHVLAKRQMSGF
G
--
G
I
V
S
I
V
L
K
GGF
D
A
-
A
---
K
-
R
-
F
C
E
K
T
E
L
F
T
L
A
E
S
---
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-----------
28
PsiBlast_CBE
90.79
45%
-95
- C1 -
4IY7
5
?
D:
[15-393]
---
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
------
A
T
S
--
T
Y
-
A
Q
S
S
--
P
G
--------
E
--------
H
------
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
-
H
-
G
-
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
NA
E
L
A
E
Q
------
M
A
--------------------------
F
L
Q
-----
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
----------------
P
----------------
G
-----------------
L
ASHPQHVLAKRQMSGF
G
--
G
I
V
S
I
V
L
K
GGF
D
A
-
A
---
K
-
R
-
F
C
E
K
T
E
L
F
T
L
A
E
S
---
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-----------
3
PsiBlast_PDB
90.65
45%
-96
- C1 -
4IYO
8
?
A:
[15-393]
---
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
------
A
T
S
--
T
Y
-
A
Q
S
S
--
P
G
--------
E
--------
H
------
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
V
I
A
R
K
-
H
-
G
-
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
-
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
G
D
N
A
E
L
A
E
Q
------
M
A
--------------------------
F
L
Q
-----
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
----------------
P
----------------
G
-----------------
L
ASHPQ
H
V
L
A
K
R
Q
M
SGF
G
--
G
I
V
S
I
V
L
K
GG
F
D
A
-
A
---
K
-
R
-
F
C
E
K
T
E
L
F
T
L
A
E
S
---
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-----------
119
HHSearch
90.48
44%
-98
- C1 -
3QHX
4
?
A:
[16-391]
---
A
G
L
A
T
R
A
I
H
S
G
Y
R
P
D
P
-
A
T
G
A
V
N
A
P
I
Y
------
A
S
S
--
T
F
-
A
Q
D
G
--
V
G
G-------
L
--------
R
------
G
G
Y
E
Y
A
R
T
G
N
P
T
R
T
A
L
E
A
A
L
A
A
V
E
D
A
A
F
G
R
A
F
S
S
G
M
A
A
A
D
C
A
-
L
R
A
-
M
L
R
P
G
D
H
V
V
I
P
D
D
A
Y
G
G
T
F
R
L
I
D
K
V
F
--
T
G
-
W
N
V
E
Y
T
P
V
AL
A
-
D
L
D
A
V
R
A
A
I
R
P
T
T
R
L
I
W
V
E
T
P
T
N
P
L
L
S
I
A
D
I
A
G
I
A
Q
L
G
A
D
-
S
-
S
-
A
K
V
L
V
D
N
T
F
A
S
P
A
L
Q
-
Q
P
L
S
L
G
A
D
V
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
-
G
A
L
V
T
N
D
--
E
E
L
D
Q
------
S
F
--------------------------
A
F
L
--
Q
--
N
G
A
G
A
V
P
G
P
F
D
A
Y
L
T
M
R
G
L
K
T
L
V
L
R
M
Q
R
H
S
E
N
A
A
A
V
A
E
F
L
A
E
H
P
A
I
S
T
V
L
Y
----------------
P
----------------
G
LPSHP
G
H
A
V
A
A
R
QMRG-
F
----------------
G
--
G
M
V
S
V
R
M
R
---
A
G
-
R
T
A
A
E
-
Q
-
L
C
A
K
T
N
I
F
I
L
A
E
S
---
L
G
S
V
E
S
L
I
E
H
P
S
A
M
T
H
A
S
T
A
G
S
---
Q
L
E
V
P
D
D
L
V
R
L
S
V
G
I
E
D
V
A
D
L
L
D
D
L
K
Q
A
L
-----------
19
PsiBlast_PDB
90.35
41%
-100
- C1 -
3QHX
4
?
A:
[20-391]
-------
T
R
A
I
H
S
G
Y
R
P
D
P
-
A
T
G
A
V
N
A
P
I
Y
------
A
S
S
--
T
F
A
Q
D
G
V
--
G
G
--------
L
--------
R
------
G
G
Y
E
Y
A
R
T
G
N
P
T
R
T
A
L
E
A
A
L
A
A
V
E
D
A
A
F
G
R
A
F
S
S
G
M
A
A
A
D
-
C
-
A
L
R
A
M
L
R
P
G
D
H
V
V
I
P
D
D
A
Y
G
G
T
F
R
L
I
D
K
V
F
T
G
W
N
-
V
E
Y
T
P
V
A
L
--
A
-
D
L
D
A
V
R
A
A
I
R
P
T
T
R
L
I
W
V
E
T
P
T
N
P
L
L
S
I
A
D
I
A
G
I
A
Q
L
G
A
D
-
S
-
S
-
A
K
V
L
V
D
N
T
F
A
S
P
A
L
Q
-
Q
P
L
S
L
G
A
D
V
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
-
G
A
L
V
T
N
D
--
E
E
L
D
Q
------
S
F
--------------------------
A
F
L
--
Q
--
N
G
A
G
A
V
P
G
P
F
D
A
Y
L
T
M
R
G
L
K
T
L
V
L
R
M
Q
R
H
S
E
N
A
A
A
V
A
E
F
L
A
E
H
P
A
I
S
T
V
L
Y
----------------
P
----------------
G
-----------------
L
PSHP
G
H
A
V
A
A
R
QMRGF
G
--
G
M
V
S
V
R
M
R
---
A
G
-
R
-
T
A
A
-
E
Q
L
C
A
K
T
N
I
F
I
L
A
E
S
---
L
G
S
V
E
S
L
I
E
H
P
S
A
M
T
H
A
S
T
---
A
G
S
Q
L
E
V
P
D
D
L
V
R
L
S
V
G
I
E
D
V
A
D
L
L
D
D
L
K
Q
A
L
-----------
1
PsiBlast_PDB
90.11
47%
-107
- C1 -
4L0O
2
METB_HELPY
H:
[18-379]
---------------------
T
G
A
V
S
V
P
I
Y
------
Q
T
S
--
T
Y
-
R
Q
D
------------------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
-
L
S
C
T
I
I
D
T
--
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
-
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
--
E
A
L
A
Q
EI----
A
F
--------------------------
F
Q
------
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
----------------
P
----------------
G
LPTHPNYELAKKQM---
R
----------------
G
FS
G
M
L
S
F
T
L
K
---
N
D
-
S
-
E
A
V
-
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
---
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--------
26
PsiBlast_CBE
89.95
47%
-107
- C1 -
4L0O
2
METB_HELPY
C:
[18-379]
---------------------
T
G
A
V
S
V
P
I
Y
------
Q
T
S
--
T
Y
-
R
Q
D
A
--
I
G
-------------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
-
L
S
C
T
I
I
D
T
--
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
-
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
--
E
A
L
A
Q
E
I
----
A
F
--------------------------
F
Q
------
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
----------------
P
----------------
G
LPT
H
P
N
Y
E
L
A
KKQM---
R
----------------
G
F
S
G
M
L
S
F
T
L
K
---
N
D
-
S
-
E
A
V
-
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
---
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
H
----------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--------
115
HHSearch
88.79
40%
-107
- C1 -
2RFV
1
?
A:
[5-397]
-
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
------
Q
T
S
--
T
F
-
V
F
D
S
--
A
E
--------
Q
G
A
A
R
F-----------
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
-
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
-
I
N
V
R
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
-
D
V
I
G
G
I
I
V
G
K
---
Q
E
F
I
D
------
Q
A
--------------------------
R
F
V
GL
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
GLSSHP
Q
Y
E
L
G
Q
R
Q
MS
L
-----------------
P
----------------
G
--
G
I
I
S
F
E
I
A
---
G
G
L
E
-
A
G
R
-
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
---
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
-------
112
HHSearch
88.72
43%
-101
- C1 -
3COG
5
CGL_HUMAN
A:
[16-400]
--
F
Q
H
F
A
T
Q
A
I
H
V
G
Q
D
P
E
Q
W
T
S
R
A
V
V
P
P
I
S
------
L
S
T
--
T
F
-
K
Q
--------------------------------------
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
-
T
-
I
T
H
-
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
F
G
-
L
K
I
S
F
V
D
C
--
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
C
A
H
I
V
H
K
-
H
G
D
-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
Q
-
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
-
G
L
V
S
V
N
C
--
E
S
L
H
N
------
R
L
--------------------------
R
F
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
----------------
P
GLPSHPQ
H
E
L
V
K
R
Q
C
T
G
-----------------
C
----------------
T
--
G
M
V
T
F
Y
I
K
---
G
T
L
Q
-
H
A
E
-
I
-
F
L
K
N
L
K
L
F
T
L
A
E
S
---
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
P
------
20
PsiBlast_PDB
88.62
41%
-100
- C1 -
3QI6
5
?
A:
[20-391]
-------
T
R
A
I
H
S
G
Y
R
P
D
P
-
A
T
G
A
V
N
A
P
I
Y
------
A
S
S
--
T
F
A
Q
D
G
V
--
G
G
--------
L
--------
R
------
G
G
Y
E
Y
A
R
T
G
N
P
T
R
T
A
L
E
A
A
L
A
A
V
E
D
A
A
F
G
R
A
F
S
S
G
M
A
A
A
D
-
C
-
A
L
R
A
M
L
R
P
G
D
H
V
V
I
P
D
D
A
Y
G
G
T
F
R
L
I
D
K
V
F
T
G
W
N
-
V
E
Y
T
P
V
A
L
--
A
-
D
L
D
A
V
R
A
A
I
R
P
T
T
R
L
I
W
V
E
T
P
T
N
P
L
L
S
I
A
D
I
A
G
I
A
Q
L
G
A
D
-
S
-
S
-
A
K
V
L
V
D
N
T
F
A
S
P
A
L
Q
-
Q
P
L
S
L
G
A
D
V
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
-
G
A
L
V
T
N
D
--
E
E
L
D
Q
------
S
F
--------------------------
A
F
L
--
Q
--
N
G
A
G
A
V
P
G
P
F
D
A
Y
L
T
M
R
G
L
K
T
L
V
L
R
M
Q
R
H
S
E
N
A
A
A
V
A
E
F
L
A
E
H
P
A
I
S
T
V
L
Y
----------------
P
----------------
G
-----------------
L
PSHP
G
H
A
V
A
A
R
QMRGF
G
--
G
M
V
S
V
R
M
R
---
A
G
-
R
-
T
A
A
-
E
Q
L
C
A
K
T
N
I
F
I
L
A
E
S
---
L
G
S
V
E
S
L
I
E
H
P
S
A
M
T
H
--
T
---
A
G
S
Q
L
E
V
P
D
D
L
V
R
L
S
V
G
I
E
D
V
A
D
L
L
D
D
L
K
Q
A
L
-----------
21
PsiBlast_CBE
88.54
47%
-106
- C1 -
4L0O
2
METB_HELPY
O:
[18-379]
---------------------
T
G
A
V
S
V
P
I
Y
------
Q
T
S
--
T
Y
-
R
Q
D
A
--
I
G
--------
R
--------
H
------
K
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
-
L
S
C
T
I
I
D
T
--
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
-
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
--
E
A
L
A
Q
EI----
A
F
--------------------------
F
Q
------
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
----------------
P
----------------
G
LPTHPNYELAKKQM---
R
----------------
G
FS
G
M
L
S
F
T
L
K
---
N
D
-
S
-
E
A
V
-
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
---
L
G
G
V
E
S
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--------
27
PsiBlast_CBE
88.04
47%
-107
- C1 -
4L0O
2
METB_HELPY
A:
[18-379]
---------------------
T
G
A
V
S
V
P
I
Y
------
Q
T
S
--
T
Y
-
R
Q
D
A
--
I
G
--------
R
--------
H
------
K
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
-
L
S
C
T
I
I
D
T
--
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
-
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
--
E
A
L
A
Q
E
I
----
A
F
--------------------------
F
Q
------
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
----------------
P
----------------
G
LPTHPN
Y
E
L
A
K
K
Q
M---
R
----------------
G
FS
G
M
L
S
F
T
L
K
---
N
D
-
S
-
E
A
V
-
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
---
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
----------------
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--------
24
PsiBlast_CBE
88.01
47%
-106
- C1 -
4L0O
1
METB_HELPY
G:
[18-379]
---------------------
T
G
A
V
S
V
P
I
Y
------
Q
T
S
--
T
Y
-
R
Q
D
A
--
I
G
--------------------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
-
L
S
C
T
I
I
D
T
--
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
-
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
--
E
A
L
A
Q
EI----
A
F
--------------------------
F
Q
------
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
----------------
P
----------------
G
LPTHPNYELAKKQM---
R
----------------
G
FS
G
M
L
S
F
T
L
K
---
N
D
-
S
-
E
A
V
-
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
---
L
G
G
V
E
S
L
V
G
I
P
A
F
M
T
----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--------
22
PsiBlast_CBE
87.59
47%
-107
- C1 -
4L0O
2
METB_HELPY
M:
[18-379]
---------------------
T
G
A
V
S
V
P
I
Y
------
Q
T
S
--
T
Y
-
R
Q
D
A
--
I
G
-------------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
-
L
S
C
T
I
I
D
T
--
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
-
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
--
E
A
L
A
Q
EI----
A
F
--------------------------
F
Q
------
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
----------------
P
----------------
G
LPTHPNYELAKKQM---
R
----------------
G
FS
G
M
L
S
F
T
L
K
---
N
D
-
S
-
E
A
V
-
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
---
L
G
G
V
E
S
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--------
113
HHSearch
87.54
40%
-104
- C1 -
1E5E
5
?
A:
[5-397]
--
R
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
-
D
-
Q
F
G
A
A
I
P
P
I
Y
------
Q
T
S
--
T
F
-
V
F
D
N
--
C
Q
Q
G
G
N
R
F
A
G
Q
--------
E
------
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
-
I
Q
V
D
F
I
N
T
--
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q
E
-
G
-
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
-
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
A
---
D
L
L
Q
------
Q
I
--------------------------
R
M
V
--
G
IK
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
----------------
P
GFEDHEG
H
D
I
A
K
K
Q
M
R
M
-----------------
Y
----------------
G
--
S
M
I
T
F
I
L
K
---
S
G
F
E
-
G
A
K
-
K
-
L
L
D
N
L
K
L
I
T
L
A
V
S
---
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
R
------
25
PsiBlast_CBE
87.25
47%
-106
- C1 -
4L0O
2
METB_HELPY
E:
[18-379]
---------------------
T
G
A
V
S
V
P
I
Y
------
Q
T
S
--
T
Y
-
R
Q
D
A
--
I
G
--------------------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
-
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
G
-
L
S
C
T
I
I
D
T
--
S
-
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
C
A
S
V
A
K
D
-
H
-
G
-
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
-
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
G
H
S
D
V
V
A
-
G
L
V
T
T
N
N
--
E
A
L
A
Q
EI----
A
F
--------------------------
F
Q
------
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
----------------
P
----------------
G
LPTHPNYELAKKQM---
R
----------------
G
FS
G
M
L
S
F
T
L
K
---
N
D
-
S
-
E
A
V
-
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
---
L
G
G
V
E
S
L
V
G
I
P
A
F
M
-----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
--------
5
PsiBlast_PDB
86.95
41%
-107
- C1 -
1IBJ
4
METC_ARATH
A:
[103-459]
-----------------------
A
M
S
T
P
L
Y
------
Q
T
A
--
T
F
-
K
Q
P
S
--
A
I
--------
E
--------
N
------
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
-
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
G
-
V
V
V
K
R
V
N
T
--
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
A
-
Q
-
G
-
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
-
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
V
K
G
--
E
K
L
A
K
------
E
V
--------------------------
Y
F
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
AGLPDHPG
H
H
L
H
F
S
Q
A
K
----------------
G
-----------------
A
----------------
G
--
S
V
F
S
F
I
T
G
---
S
V
-
A
-
L
S
K
-
H
-
L
V
E
T
T
K
Y
F
S
I
A
V
S
---
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
-----------
116
HHSearch
86.83
41%
-102
- C1 -
1IBJ
4
METC_ARATH
A:
[85-461]
---
A
S
V
S
T
L
L
V
N
L
D
N
K
F
-
D
-
P
F
D
A
M
S
T
P
L
Y
------
Q
T
A
--
T
F
-
K
Q
P
S
--
A
I
--------
E
--------
N
------
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
V
-
T
-
H
-
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
G
-
V
V
V
K
R
V
N
T
--
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
A
-
Q
-
G
-
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
-
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
V
K
G
--
E
K
L
A
K
------
E
V
--------------------------
Y
F
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
----------------
A
GLPDHPG
H
H
L
H
F
S
Q
A
K
G
-----------------
A
----------------
G
--
S
V
F
S
F
I
T
G
---
S
V
-
A
-
L
S
K
-
H
-
L
V
E
T
T
K
Y
F
S
I
A
V
S
---
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
----
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
-----
6
PsiBlast_PDB
86.70
40%
-102
- C1 -
4OMA
6
?
A:
[17-393]
-------------
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
------
Q
T
S
T
F
V
F
-
D
S
A
E
--
Q
G
--------
A
--------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
-
I
N
V
S
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
--
E
F
I
D
Q
------
A
R
--------------------------
F
V
G
--
L
K-
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
----------------
G
LSSHPQ
Y
E
L
G
Q
R
Q
M
SL-
P
----------------
G
--
G
I
I
S
F
E
I
A
---
G
G
-
L
-
E
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
---
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-----------
42
PsiBlast_CBE
86.37
39%
-103
- C1 -
1E5E
6
?
B:
[16-396]
--------------
N
P
Q
K
D
-
Q
F
G
A
A
I
P
P
I
Y
QTSTFV
F
D
N
--
C
Q
-
Q
G
G
N
RF
A
G
--------
Q
--------
E
------
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
-
I
Q
V
D
F
I
N
T
--
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
-
E
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
-
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
A
--
D
L
L
Q
Q
------
I
R
--------------------------
M
V
G
--
I
K-
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
----------------
P
----------------
G
FEDHEGHDIAKKQMRM-
Y
----------------
G
--
S
M
I
T
F
I
L
K
---
S
G
F
E
-
G
A
K
-
K
-
L
L
D
N
L
K
L
I
T
L
A
V
S
---
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
-------
18
PsiBlast_PDB
85.68
39%
-102
- C1 -
1E5F
6
?
A:
[16-396]
--------------
N
P
Q
K
D
-
Q
F
G
A
A
I
P
P
I
Y
QTS
T
F
V
F
D
N
--
C
Q
-
Q
G
G
N
R
F
A
G
--------
Q
--------
E
------
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
-
I
Q
V
D
F
I
N
T
--
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
-
E
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
-
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
A
--
D
L
L
Q
Q
------
I
R
--------------------------
M
V
G
--
I
K-
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
----------------
P
----------------
G
FEDHEG
H
D
I
A
K
K
Q
M
RM-
Y
----------------
G
--
S
M
I
T
F
I
L
K
---
S
G
F
E
-
G
A
K
-
K
-
L
L
D
N
L
K
L
I
T
L
A
V
S
---
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
-------
9
PsiBlast_PDB
85.67
40%
-100
- C1 -
4HF8
5
?
A:
[17-393]
-------------
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
------
Q
T
S
T
F
V
F
-
D
S
A
E
--
Q
G
--------
A
--------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
-
I
N
V
R
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
--
E
F
I
D
Q
------
A
R
--------------------------
F
V
G
--
L
K-
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
----------------
G
LSSHPQ
Y
E
L
G
Q
R
QMSL-
P
----------------
G
--
G
I
I
S
F
E
I
A
---
G
G
-
L
-
E
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
---
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-----------
10
PsiBlast_PDB
85.52
40%
-101
- C1 -
3JWA
6
?
A:
[17-393]
-------------
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
------
Q
T
S
T
F
V
F
-
D
S
A
E
--
Q
G
--------
A
--------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
-
I
N
V
S
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
--
E
F
I
D
Q
------
A
R
--------------------------
F
V
G
--
L
K-
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
----------------
G
LSSHP
Q
Y
E
L
G
Q
R
Q
MSL-
P
----------------
G
--
G
I
I
S
F
E
I
A
---
G
G
-
L
-
E
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
---
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-----------
11
PsiBlast_PDB
85.43
40%
-100
- C1 -
3JWB
4
?
A:
[17-393]
-------------
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
------
Q
T
S
T
F
V
F
-
D
S
A
E
--
Q
G
--------
A
--------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
-
I
N
V
S
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
--
E
F
I
D
Q
------
A
R
--------------------------
F
V
G
--
L
K-
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
----------------
G
LSSHP
Q
Y
E
L
G
Q
R
Q
MSL-
P
----------------
G
--
G
I
I
S
F
E
I
A
---
G
G
-
L
-
E
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
---
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-----------
41
PsiBlast_CBE
84.74
39%
-105
- C1 -
1E5F
5
?
B:
[16-396]
--------------
N
P
Q
K
D
-
Q
F
G
A
A
I
P
P
I
Y
QTSTFV
F
D
N
--
C
Q
-
Q
G
G
N
RF
A
G
--------
Q
--------
E
------
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
-
I
Q
V
D
F
I
N
T
--
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
-
E
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
-
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
A
--
D
L
L
Q
Q
------
I
R
--------------------------
M
V
G
--
I
K-
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
----------------
P
----------------
G
FEDHEGHDIAKKQMRM-
Y
----------------
G
--
S
M
I
T
F
I
L
K
---
S
G
F
E
-
G
A
K
-
K
-
L
L
D
N
L
K
L
I
T
L
A
V
S
---
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
-------
31
PsiBlast_CBE
84.54
41%
-105
- C1 -
1IBJ
3
METC_ARATH
C:
[103-459]
-----------------------
A
M
S
T
P
L
Y
------
Q
T
A
--
T
F
-
K
Q
P
S
--
A
I
--------
E
--------
N
------
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
-
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
G
-
V
V
V
K
R
V
N
T
--
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
A
-
Q
-
G
-
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
-
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
V
K
G
--
E
K
L
A
K
------
E
V
--------------------------
Y
F
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
AGLPDHPGHHLHFSQA
K
----------------
G
-----------------
A
----------------
G
--
S
V
F
S
F
I
T
G
---
S
V
-
A
-
L
S
K
-
H
-
L
V
E
T
T
K
Y
F
S
I
A
V
S
---
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
-----------
12
PsiBlast_PDB
83.95
40%
-102
- C1 -
3JW9
2
?
A:
[17-393]
-------------
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
------
Q
T
S
T
F
V
F
-
D
S
A
E
--
Q
G
--------
A
--------
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
-
I
N
V
S
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
--
E
F
I
D
Q
------
A
R
--------------------------
F
V
G
--
L
K-
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
----------------
G
LSSHP
Q
Y
E
L
G
Q
R
Q
MSL-
P
----------------
G
--
G
I
I
S
F
E
I
A
---
G
G
-
L
-
E
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
---
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-----------
17
PsiBlast_PDB
82.94
39%
-102
- C1 -
1E5E
5
?
A:
[16-396]
--------------
N
P
Q
K
D
-
Q
F
G
A
A
I
P
P
I
Y
QTS
T
F
V
F
D
N
--
C
Q
-
Q
G
G
N
R
F
A
G
--------
Q
--------
E
------
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
-
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
-
I
Q
V
D
F
I
N
T
--
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
-
Q
-
E
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
-
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
A
--
D
L
L
Q
Q
------
I
R
--------------------------
M
V
G
--
I
K-
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
----------------
P
----------------
G
FEDHEG
H
D
I
A
K
K
Q
M
RM-
Y
----------------
G
--
S
M
I
T
F
I
L
K
---
S
G
F
E
-
G
A
K
-
K
-
L
L
D
N
L
K
L
I
T
L
A
V
S
---
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
-------
8
PsiBlast_PDB
82.16
40%
-102
- C1 -
3MKJ
1
?
A:
[17-393]
-------------
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
------
Q
T
S
T
F
V
F
-
D
S
A
E
--
Q
G
--------
A
--------
A
R
F-----------
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
-
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
-
I
N
V
S
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
-
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
-
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
I
I
V
G
K
Q
--
E
F
I
D
Q
------
A
R
--------------------------
F
V
G
--
L
K-
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
----------------
P
----------------
G
LSS
H
P
Q
Y
E
L
G
Q
RQMSL-
P
----------------
G
--
G
I
I
S
F
E
I
A
---
G
G
-
L
-
E
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
---
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-----------
44
PsiBlast_CBE
81.35
42%
-109
- C1 -
1PFF
18
?
A:
[2-331]
------------------------------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
-
A
S
V
W
T
-
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
G
-
V
E
V
D
F
I
D
M
--
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
-
Q
K
D
-
I
L
V
I
V
D
N
T
F
A
S
P
I
L
T
-
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
V
C
S
R
A
--
D
I
I
A
K
------
V
K
--------------------------
S
Q
G
--
I
K-
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
----------------
P
----------------
G
-----------------
L
PDHPG
H
E
I
A
K
K
Q
MKMF
G
--
S
M
I
A
F
D
V
D
---
G
L
-
E
-
K
A
K
-
K
-
V
L
D
N
C
H
V
V
S
L
A
V
S
---
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V
L
-------
125
HHSearch
80.27
44%
-107
* C1 *
1PFF
18
?
A:
[2-329]
------------------------------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
-
V
W
T
-
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
G
-
V
E
V
D
F
I
D
M
--
A
-
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
A
V
K
Q
A
R
K
Q
K
-
D
-
I
L
V
I
V
D
N
T
F
A
S
P
I
L
T
-
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
V
C
S
R
A
---
D
I
I
A
------
K
V
--------------------------
K
S
Q
--
G
IK
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
----------------
P
----------------
G
LPDHPG
H
E
I
A
K
K
Q
MKM-
F
----------------
G
--
S
M
I
A
F
D
V
D
---
G
L
-
E
-
K
A
K
-
K
----
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
---------
122
HHSearch
71.82
31%
-95
- C1 -
2CTZ
1
?
A:
[2-421]
----
R
F
E
T
L
Q
L
H
A
G
Y
E
P
E
P
-
T
T
L
S
R
Q
V
P
I
Y
------
P
T
T
--
S
Y
-
V
F
K
S
--
P
E
--------
H
A
A
N
L
F
A
LK
E
------
F
G
N
I
Y
S
R
I
M
N
P
T
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
T
A
S
G
H
A
A
Q
F
L
A
-
L
T
T
-
L
A
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
L
G
-
I
E
V
R
F
T
S
R
--
E
E
R
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
L
A
Q
A
A
R
E
-
K
-
G
-
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
G
H
G
A
-
V
I
-
A
G
A
I
V
D
G
--
G
N
F
P
W
EGGRYP
L
L
TEPQPGYHGLRLTEAFGEL
A
F
I
V
K
A
R
V
D
G
--
L
--
R
D
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
----------------
P
----------------
G
LPHHPH
H
D
R
A
Q
K
Y
FKGK
P
----------------
G
--
A
V
L
T
F
G
L
K
---
G
G
Y
E
-
A
A
K
-
R
-
F
I
S
R
L
K
L
I
S
H
L
A
N
---
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
Q
A
G
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
A
----------