@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1689: (2016-03-27 )
MRKMKRLTWDETKITAFQEALVSWYEANKRVLPWRENTEPYRIWVSEIMLQQTKVDTVIPYFNRFMTQFPTMESFVNADEADILKAWEGLGYYSRVRNLQTAMKQVMADFSGEVPTDLTTILSLKGVGPYTAGAILSIAYNQAEPAVDGNVMRVIARVLEIGEDIMKASTRKIFEEVLYQLIDKKNPAAFNQGLMEIGALVCTPTKPMCMLCPLQPFCEAHKNGVETNYPVKIKKVKMKTKELLSIIVISEDGKIAIEKRPENGLLANMWQFPTIEISKKENDEVAKLQFLHNYGLEVLLEDEPIAHIKHVFSHLVWKMDIRVAKLQSAIPNENWYFATEEEMKRLAFPVPYQKMWQAWKDFKGE
Atome Classification :
(23 SA)
.........10........20......-..30.-........--------40........50........60........70........80........90........100.......110.......120..-.....130.......140.......150.......160.......170.......180.......----190.......200.......210.......220.......230.......240.......250.......260.......270.......280...-....290.......300.......310.......320.......-330..-..-...340.......350.......360...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRKMKRLTWD
E
T
K
I
T
A
F
Q
E
A
L
V
S
W
Y
EA-N
K
R
-V-LPWRENTE--------P
Y
R
I
W
V
S
E
I
M
L
Q
QTKV
D
T
V
I
P
Y
F
N
R
F
M
T
QFP
T
M
E
S
F
VNA
D
E
A
D
I
L
K
A
W
EGL
G
Y
Y
S
R
V
R
N
L
Q
T
A
M
K
Q
V
M
A
D
FSGEVP
T
D
L
T
T
I
LSL-KGVGPYTA
G
A
I
L
S
I
A
YNQAEPAVD
G
N
V
M
R
V
I
A
R
V
L
E
I
G
E
D
I
M
K
A
S
T
R
K
I
F
E
E
V
L
Y
Q
L
IDKKN
P
A
A
----
F
N
Q
G
L
M
E
I
G
A
L
VCTPTK
P
M
C
M
LCP
L
Q
P
F
C
E
A
H
KNGVETNY
P
V
K
I
K
K
V
K
M
K
T
K
E
L
L
S
I
I
V
ISED
G
K
I
A
I
E
KRPENGLLANMWQFP
T
I
E
ISKKEND
E
V
-
A
K
L
Q
F
L
H
NYG
L
E
V
L
LEDEP
I
A
H
I
K
H
V
F
S
H
L
V
W
K
MDI
R
V
A
K
L
Q
S
A-IPNE
N
-
W
Y
-FA
T
E
E
E
M
K
RLAFPV
P
Y
Q
K
M
W
Q
A
W
K
DFKGE
36
HHSearch
96.18
47%
-109
* C4 *
3FSP
4
?
A:
[11-361]
-----------
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
-
L
P
W
R
K
D
R
D
--------
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
-
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
----
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
-
G
A
D
G
K
E
K
L
E
Q
M
V
G
E
Q
Y
G
L
Q
V
E
L
T
E
-
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
E
P
-
Y
R
-
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
---
4
PsiBlast_PDB
96.16
48%
-109
- C4 -
3FSP
4
?
A:
[16-361]
----------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
-
L
P
W
R
K
D
R
D
--------
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
-
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
----
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
-
L
E
Q
M
V
G
E
Q
Y
G
L
Q
V
E
L
-
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
-
G
P
V
E
E
-
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
---
6
PsiBlast_PDB
95.21
48%
-109
- C4 -
4YPR
5
?
A:
[16-361]
----------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
-
L
P
W
R
K
D
R
D
--------
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
-
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
----
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
-
L
E
Q
M
V
G
E
Q
Y
G
L
Q
V
E
L
-
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
-
G
P
V
E
E
-
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
---
7
PsiBlast_PDB
94.50
48%
-110
- C4 -
1RRS
4
?
A:
[16-361]
----------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
-
L
P
W
R
K
D
R
D
--------
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
-
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
----
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
---
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
-
L
E
Q
M
V
----
G
L
Q
V
E
L
-
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
-
G
P
V
E
E
-
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
---
3
PsiBlast_PDB
94.34
48%
-111
- C4 -
4YPH
4
?
A:
[16-361]
----------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
-
L
P
W
R
K
D
R
D
--------
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
-
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
----
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
-
L
E
Q
M
V
----
G
L
Q
V
E
L
-
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
-
G
P
V
E
E
-
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
---
2
PsiBlast_PDB
93.79
48%
-109
- C4 -
4YOQ
5
?
A:
[16-361]
----------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
-
L
P
W
R
K
D
R
D
--------
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
-
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
----
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
-
L
E
Q
M
V
----
G
L
Q
V
E
L
-
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
-
G
P
V
E
E
-
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
---
59
Fugue
93.42
46%
-100
- C4 -
1RRQ
4
?
A:
[12-362]
------------
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
-
L
P
W
R
K
D
R
D
--------
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
-
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
----
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
----
M
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
-
L
E
Q
M
V
G
L
Q
V
E
L
T
-----
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
-
G
P
V
E
E
P
Y
R
-
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
--
8
PsiBlast_PDB
93.18
48%
-111
- C4 -
1VRL
5
?
A:
[16-361]
----------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
-
L
P
W
R
K
D
R
D
--------
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
-
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
----
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
--
D
G
K
E
K
-
L
E
Q
M
V
----
G
L
Q
V
E
L
-
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
-
G
P
V
E
E
-
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
---
5
PsiBlast_PDB
92.93
48%
-105
- C4 -
1RRQ
4
?
A:
[16-361]
----------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
-
L
P
W
R
K
D
R
D
--------
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
-
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
----
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
-
L
E
Q
M
V
----
G
L
Q
V
E
L
-
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
-
G
P
V
E
E
-
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
---
21
PsiBlast_CBE
92.49
48%
-103
- C4 -
4YPR
3
?
B:
[16-361]
----------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
-
L
P
W
R
K
D
R
D
--------
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
-
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
----
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
-
L
E
Q
M
V
G
-----
Q
V
E
L
-
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
-
G
P
V
E
E
-
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
---
1
PsiBlast_PDB
92.06
48%
-106
- C4 -
3G0Q
4
?
A:
[5-350]
----------------
F
Q
R
D
L
L
D
W
F
A
R
-
E
R
R
-
D
-
L
P
W
R
K
D
R
D
--------
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
L
-
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
----
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
G
A
D
G
K
E
K
-
L
E
Q
M
V
----
G
L
Q
V
E
L
-
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
-
G
P
V
E
E
-
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
---
10
PsiBlast_PDB
77.12
42%
-108
- C4 -
1KG5
6
MUTY_ECOLI
A:
[2-225]
------------
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
-
L
P
W
Q
I
D
K
T
--------
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
-
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
Q
R
V
L
A
R
C
Y
A
V
S
----
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
76.79
42%
-109
- C4 -
1KG2
6
MUTY_ECOLI
A:
[2-224]
------------
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
-
Y
G
R
K
T
-
L
P
W
Q
I
D
K
T
--------
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
-
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
----
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
---------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
76.64
41%
-105
- C4 -
1MUD
4
MUTY_ECOLI
A:
[2-225]
------------
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
-
L
P
W
Q
I
D
K
T
--------
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
-
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
----
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.59
43%
-112
- C4 -
3N5N
2
MUTYH_HUMAN
Y:
[11-237]
---------
D
V
A
E
V
T
A
F
R
G
S
L
L
S
W
Y
D
Q
-
E
K
R
-
D
-
L
P
W
R
R
R
A
E
DEMDLDRR
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
V
R
A
I
G
A
D
P
S
S
T
L
V
S
Q
Q
L
W
G
L
A
Q
Q
L
V
D
P
A
R
P
G
D
----
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
--------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.52
42%
-107
- C4 -
1KG4
4
MUTY_ECOLI
A:
[2-224]
------------
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
-
L
P
W
Q
I
D
K
T
--------
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
-
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
S
----
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
---------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
76.42
42%
-108
- C4 -
1MUY
4
MUTY_ECOLI
A:
[2-225]
------------
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
-
L
P
W
Q
I
D
K
T
--------
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
-
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
----
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.37
42%
-105
- C4 -
1KG6
8
MUTY_ECOLI
A:
[2-224]
------------
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
-
L
P
W
Q
I
D
K
T
--------
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
-
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
R
R
V
L
A
R
C
Y
A
V
S
----
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
---------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.31
42%
-104
- C4 -
1WEG
4
MUTY_ECOLI
A:
[2-225]
------------
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
-
L
P
W
Q
I
D
K
T
--------
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
-
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
S
----
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
76.18
42%
-106
- C4 -
1KG3
7
MUTY_ECOLI
A:
[2-224]
------------
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
-
L
P
W
Q
I
D
K
T
--------
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
-
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
----
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
---------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
75.70
41%
-105
- C4 -
1MUN
7
MUTY_ECOLI
A:
[2-225]
------------
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
-
L
P
W
Q
I
D
K
T
--------
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
-
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
----
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
75.08
41%
-102
- C4 -
1KQJ
5
MUTY_ECOLI
A:
[2-225]
------------
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
-
T
-
L
P
W
Q
I
D
K
T
--------
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
-
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
----
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
H
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
--------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
73.74
42%
-103
- C4 -
1WEI
5
MUTY_ECOLI
A:
[2-224]
------------
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
-
Y
G
R
-
A
T
L
P
W
Q
I
D
K
T
--------
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
L
-
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
-
Y
A
V
S
----
G
W
P
G
K
K
E
V
E
N
K
L
W
-
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
-
C
T
R
S
K
P
K
C
-
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
---------------------------------------------------------------------------------------------------------------------------------------