@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1698: (2016-03-27 )
MRITGERIYLRPFQIIDANQKLAFHLANKAFFEGYSMERDDRFYTIEEQQSLISRLEDFAASDVEYYYGIFLNDTDELIGTINLFSILRESLQSAFIGYFLDKKHNGNGYATEAVQLIVDFGFDILGLHRIEAGVMPKNERSKQVLLKAGFHLEGLAVQNVRINGTWEDHQVLAIINPGD
Atome Classification :
(20 SA)
--.........10...-.-....20.----.......30........40........50.....---...60.........70........80........90.......-..-100........110.......120.......130.......140.......150.......160-.-......170.......180-------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MRITG
E
R
I
Y
L
R
P
F
Q
-
I
-IDANQ
K
L
----
A
F
H
L
A
N
K
A
F
FEGYSMERDD
R
F
Y
T
I
E
E
Q
Q
S
L
I
S
R
L
---
E
D
F
A
-ASD
V
E
Y
Y
Y
G
I
F
LN
D
T
D
E
L
I
G
T
I
N
L
F
S
I
L
R
E
-
S
L
Q
S
A
F
I
-
G
Y
-
F
-LDKKHNGNG
Y
A
T
E
A
V
Q
L
I
V
D
FG
F
D
I
L
G
L
H
R
IEAGVMPKNER
S
K
Q
V
L
L
KAGF
H
L
E
G
L
A
V
Q
N
V
R
-
I
-
N
G
TWED
H
Q
V
L
A
I
INPGD---------------------------------------------------------------------------------------------------------------------------
53
HHSearch
96.75
28%
-96
- C1 -
3IGR
2
?
A:
[4-182]
---
S
F
E
F
E
H
Y
Q
V
R
L
I
K
-
S
-
S
D
A
V
T
I
A
----
N
Y
F
M
R
N
R
H
H
L
A
P
W
E
P
K
R
S
H
A
F
F
T
P
E
G
W
K
Q
R
L
L
Q
L
---
V
E
L
H
-
K
H
N
L
A
F
Y
F
V
V
V
D
K
N
E
H
K
I
I
G
T
V
S
Y
S
N
I
T
R
F
-
P
F
H
A
G
H
V
-
G
Y
-
S
-
L
D
S
E
Y
Q
G
K
G
I
M
R
R
A
V
N
V
T
I
D
W
M
F
K
A
Q
N
L
H
R
I
M
A
A
Y
I
P
R
N
E
K
S
A
K
V
L
A
A
L
G
F
V
K
E
G
E
A
K
K
Y
L
Y
-
I
-
N
G
A
W
E
D
H
I
L
T
S
K
I
N
D
D
W
---------------------------------------------------------------------------------------------------------------------------
51
HHSearch
84.83
26%
-109
- C1 -
3FBU
1
?
A:
[1-168]
--
M
F
I
K
A
E
R
L
L
I
R
K
F
E
-
F
-
K
D
W
E
A
V
H
----
E
Y
T
S
D
-
S
D
V
-
M
K
Y
I
P
E
G
---
V
F
T
E
E
D
T
R
N
F
V
N
K
N
---
M
G
-------
A
K
N
F
P
V
I
L
I
G
E
N
I
L
V
G
H
I
V
F
H
K
Y
F
---
G
E
H
T
Y
E
I
-
G
W
-
V
-
F
N
P
K
Y
F
N
K
G
Y
A
S
E
A
A
Q
A
T
L
K
Y
G
F
K
E
M
K
L
H
R
I
I
A
T
C
Q
P
E
N
T
P
S
Y
R
V
M
E
K
I
G
M
R
R
E
G
Y
F
K
K
C
I
P
-
H
-
G
N
E
W
W
D
E
Y
Y
Y
A
I
L
E
E
E
----------------------------------------------------------------------------------------------------------------------------
72
Fugue
84.12
25%
-111
- C1 -
3FBU
1
?
A:
[1-168]
--
M
F
I
K
A
E
R
L
L
I
R
K
F
E
-
F
-
K
D
W
E
A
V
H
----
E
Y
T
S
D
S
D
V
M
-----
K
Y
I
P
E
G
V
F
T
E
E
D
T
R
N
F
V
N
K
N
---
M
G
A
-------
K
N
F
P
V
I
L
I
G
E
N
I
L
V
G
H
I
V
F
H
K
Y
F
G
E
---
H
T
Y
E
I
-
G
W
-
V
-
F
N
P
K
Y
F
N
K
G
Y
A
S
E
A
A
Q
A
T
L
K
Y
G
F
K
E
M
K
L
H
R
I
I
A
T
C
Q
P
E
N
T
P
S
Y
R
V
M
E
K
I
G
M
R
R
E
G
Y
F
K
K
C
I
P
-
H
-
G
N
E
W
W
D
E
Y
Y
Y
A
I
L
E
E
E
----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.48
31%
-94
- C1 -
3IGR
2
?
A:
[30-179]
-----------------------------------
N
R
H
H
L
A
P
W
E
P
K
R
S
H
A
F
F
T
P
E
G
W
K
Q
R
L
L
Q
L
---
V
E
L
H
-
K
H
N
L
A
F
Y
F
V
V
V
D
K
N
E
H
K
I
I
G
T
V
S
Y
S
N
I
T
R
F
-
P
F
H
A
G
H
V
-
G
Y
-
S
-
L
D
S
E
Y
Q
G
K
G
I
M
R
R
A
V
N
V
T
I
D
W
M
F
K
A
Q
N
L
H
R
I
M
A
A
Y
I
P
R
N
E
K
S
A
K
V
L
A
A
L
G
F
V
K
E
G
E
A
K
K
Y
L
Y
-
I
-
N
G
A
W
E
D
H
I
L
T
S
K
I
N
------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
80.16
22%
-93
- C1 -
2FCK
13
?
A:
[10-181]
----
I
V
T
Q
R
L
Q
L
R
L
I
T
-
A
-
D
E
A
E
E
L
V
----
Q
C
I
R
Q
S
Q
T
L
-
H
Q
W
V
D
W
-----
F
S
Q
Q
E
A
E
Q
F
I
Q
A
T
---
R
L
N
W
-
V
K
A
E
A
Y
G
F
G
V
F
E
R
Q
T
Q
T
L
V
G
M
V
A
I
N
E
F
Y
-
H
-
T
F
N
M
A
S
L
-
G
Y
-
W
-
I
G
D
R
Y
Q
R
Q
G
Y
G
K
E
A
L
T
A
L
I
L
F
C
F
E
R
L
E
L
T
R
L
E
I
V
C
D
P
E
N
V
P
S
Q
A
L
A
L
R
C
G
A
N
R
E
Q
L
A
P
N
R
F
L
-
Y
-
A
G
E
P
K
A
G
I
V
F
S
L
I
P
------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
76.39
25%
-93
- C1 -
2FSR
2
?
A:
[29-178]
---
T
L
R
T
E
R
L
T
L
R
P
L
A
-
M
-
A
D
F
P
A
Y
R
----
D
F
M
A
S
-
P
R
S
T
-
G
V
G
G
P
Y
-----
D
L
P
S
T
W
G
V
F
C
H
D
---
L
A
N
W
-
H
F
F
G
H
G
A
L
M
I
D
L
G
E
T
G
E
C
I
G
Q
I
G
I
N
H
G
P
---
L
F
P
E
K
E
L
-
G
W
-
L
-
L
Y
E
G
H
E
G
R
G
Y
A
A
E
A
A
V
A
L
R
D
W
A
F
E
T
L
N
L
P
T
L
V
S
Y
V
S
P
Q
N
R
K
S
A
A
V
A
E
R
I
G
G
T
L
D
P
L
A
P
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------
81
Fugue
72.48
23%
-84
- C1 -
4MI4
2
ATDA_VIBCH
A:
[26-195]
------
N
S
Q
L
T
L
R
A
L
E
----
R
G
D
L
R
F
----
I
H
N
L
N
N
N
R
N
I
M
S
Y
W
F
E
E
P
Y
------
E
S
F
D
E
L
E
E
L
---
Y
N
K
H
-
I
H
D
N
A
E
R
R
F
V
V
E
D
A
Q
K
N
L
I
G
L
V
E
L
I
E
I
N
Y
I
-
H
-
R
S
A
E
F
-
Q
I
-
I
-
I
A
P
E
H
Q
G
K
G
F
A
R
T
L
I
N
R
A
L
D
Y
S
F
T
I
L
N
L
H
K
I
Y
L
H
V
A
V
E
N
P
K
A
V
H
L
Y
E
E
C
G
F
V
E
E
G
H
L
V
E
E
F
F
-
I
-
N
G
R
Y
Q
D
V
K
R
M
Y
I
L
Q
S
K
Y
L
N
R------------------------------------------------------------------------------------------------------------------------
77
Fugue
72.28
23%
-79
- C1 -
4MHD
1
ATDA_VIBCH
A:
[26-195]
------
N
S
Q
L
T
L
R
A
L
E
----
R
G
D
L
R
F
----
I
H
N
L
N
N
N
R
N
I
M
S
Y
W
F
E
E
P
Y
------
E
S
F
D
E
L
E
E
L
---
Y
N
K
H
-
I
H
D
N
A
E
R
R
F
V
V
E
D
A
Q
K
N
L
I
G
L
V
E
L
I
E
I
N
Y
I
-
H
-
R
S
A
E
F
-
Q
I
-
I
-
I
A
P
E
H
Q
G
K
G
F
A
R
T
L
I
N
R
A
L
D
Y
S
F
T
I
L
N
L
H
K
I
Y
L
H
V
A
V
E
N
P
K
A
V
H
L
Y
E
E
C
G
F
V
E
E
G
H
L
V
E
E
F
F
-
I
-
N
G
R
Y
Q
D
V
K
R
M
Y
I
L
Q
S
K
Y
L
N
R------------------------------------------------------------------------------------------------------------------------
64
HHSearch
70.77
17%
-102
- C1 -
2VZY
3
Y802_MYCTU
A:
[11-190]
---
R
I
T
T
P
R
L
Q
L
Q
L
P
T
-
E
-
E
L
C
D
Q
L
I
D
T
I
L
E
----------------------
E
D
L
P
F
N
T
L
S
H
L
W
Q
Q
L
A
G
F
K
R
D
D
W
S
L
P
L
A
V
L
V
--
D
G
R
A
V
G
V
Q
A
L
S
S
K
D
F
P
-
I
T
R
Q
V
D
S
-
G
S
-
W
-
L
G
L
R
Y
Q
G
H
G
Y
G
T
E
M
R
A
A
V
L
Y
F
A
F
A
E
L
E
A
Q
V
A
T
S
R
S
F
V
D
N
P
A
S
I
A
V
S
R
R
N
G
Y
R
D
N
G
L
D
R
V
A
R
----
E
G
A
M
A
E
A
L
L
F
R
L
T
R
D
D
W
---------------------------------------------------------------------------------------------------------------------------
56
HHSearch
69.93
19%
-83
- C1 -
3PZJ
2
?
A:
[33-205]
---
A
I
R
G
E
A
V
S
L
Q
P
L
D
A
P
-
R
H
G
A
A
L
F
----
R
L
F
A
G
D
D
S
H
W
E
-
H
L
P
Y
G
--
P
F
E
D
E
D
A
F
I
T
W
L
A
L
T
---
V
A
----
Q
S
D
T
A
L
Y
V
V
C
A
K
D
S
D
Q
A
L
G
F
L
G
Y
R
Q
M
V
-
Q
-
A
H
G
A
I
E
I
-
G
H
-
V
N
F
S
P
A
L
R
R
T
R
L
A
T
E
A
V
F
L
L
L
K
T
A
F
E
-
L
G
Y
R
R
C
E
W
R
C
D
S
R
N
A
A
S
A
A
A
A
R
R
F
G
F
Q
F
E
G
T
L
R
Q
A
M
V
-
V
-
K
R
R
N
R
D
T
H
V
F
S
M
L
D
G
E
W
---------------------------------------------------------------------------------------------------------------------------
78
Fugue
69.68
17%
-91
- C1 -
2ZW5
1
?
A:
[9-301]
-T
A
H
L
R
T
A
R
L
E
L
T
P
L
D
-
P
-
A
A
D
A
R
H
L
----
H
H
A
Y
G
D
E
E
V
M
R
W
W
T
R
---
P
A
C
A
D
P
A
E
T
E
R
Y
L
T
S
C
---
A
A
-----
A
P
G
A
R
L
W
T
I
R
A
P
D
G
T
V
P
G
M
A
G
L
L
G
-----
G
T
D
V
P
G
L
-
T
W
-
L
-
L
R
R
D
S
W
G
H
G
Y
A
T
E
A
A
A
A
V
V
G
H
A
L
E
D
G
G
L
D
R
V
E
A
W
I
E
A
G
N
R
R
S
L
A
V
A
A
R
V
G
L
T
E
R
A
R
L
A
Q
H
Y
P
-
H
-
R
P
G
P
H
E
M
V
V
L
G
K
A
R
A
E
E
PLTTL
A
V
I
T
E
L
PVRD
V
A
A
T
L
R
L
V
E
A
A
L
GARTAFAIGDPPE
F
A
E
A
A
LTPWSA
G
P
R
F
R
L
A
A
V
P
GP
G
P
V
E
P
V
R
L
H
L
DAAGT
A
D
S
L
H
R
R
A
V
D
A
GARVDGP
P
V
R
R
PWG
R
S
E
F
V
I
T
L
PEG
H
E
L
T
V
S
A
PV
61
HHSearch
68.89
19%
-71
- C1 -
3TCV
-
?
A:
[17-192]
---
I
F
E
G
R
Y
V
R
L
E
P
L
N
-
A
Q
K
H
G
D
E
L
F
----
A
A
S
S
V
-
E
D
A
E
Q
R
F
T
W
L
F
E
T
P
P
A
T
R
A
E
F
E
P
W
L
D
K
A
---
S
----
K
S
D
D
P
L
F
F
A
V
I
D
K
A
S
G
K
V
A
G
R
Q
A
L
M
R
I
D
-
P
-
A
N
G
V
I
E
I
-
G
S
-
I
Y
W
G
P
L
I
S
R
R
P
A
A
T
E
A
Q
F
L
F
M
Q
Y
V
F
D
V
L
G
Y
R
R
Y
E
W
E
C
H
N
E
N
G
P
S
R
R
A
A
E
R
F
G
F
R
F
E
G
I
F
R
Q
H
M
V
-
V
-
K
G
R
N
R
D
T
A
W
F
S
V
L
D
S
E
W
---------------------------------------------------------------------------------------------------------------------------
57
HHSearch
68.38
22%
-102
- C1 -
3WR7
2
?
A:
[2-165]
--------
S
V
K
L
R
P
L
E
-
R
-
E
D
L
R
Y
V
H
----
Q
L
D
N
N
-
A
S
V
M
R
Y
W
F
E
E
P
Y
---
E
A
F
V
E
L
S
D
L
Y
D
K
H
---
I
H
----
D
Q
S
E
R
R
F
V
V
E
C
--
D
G
E
K
A
G
L
V
E
L
V
E
I
N
-
H
-
V
H
R
R
A
E
F
-
Q
I
-
I
-
I
S
P
E
Y
Q
G
K
G
L
A
T
R
A
A
K
L
A
M
D
Y
G
F
T
V
L
N
L
Y
K
L
Y
L
I
V
D
K
E
N
E
K
A
I
H
I
Y
R
K
L
G
F
S
V
E
G
E
L
M
H
E
F
F
-
I
-
N
G
Q
Y
R
N
A
I
R
M
C
I
F
Q
H
Q
Y
---------------------------------------------------------------------------------------------------------------------------
66
HHSearch
68.28
19%
-83
- C1 -
2ZW5
1
?
A:
[11-178]
---
H
L
R
T
A
R
L
E
L
T
P
L
D
-
P
A
A
D
A
R
H
L
H
----
H
A
Y
G
D
-
E
E
V
-
M
R
W
W
T
R
P
A
--
C
A
D
P
A
E
T
E
R
Y
L
T
S
C
---
A
A
----
A
P
G
A
R
L
W
T
I
R
A
P
-
D
G
T
V
P
G
M
A
G
L
L
G
G
-----
T
D
V
P
G
L
-
T
W
-
L
-
L
R
R
D
S
W
G
H
G
Y
A
T
E
A
A
A
A
V
V
G
H
A
L
E
D
G
G
L
D
R
V
E
A
W
I
E
A
G
N
R
R
S
L
A
V
A
A
R
V
G
L
T
E
R
A
R
L
A
Q
H
Y
P
-
H
-
R
P
G
P
H
E
M
V
V
L
G
K
A
R
A
E
E
---------------------------------------------------------------------------------------------------------------------------
62
HHSearch
67.37
22%
-101
- C1 -
3TTH
1
?
A:
[5-168]
-------
K
K
I
R
L
S
A
L
E
-
R
-
E
D
L
K
F
V
H
----
E
L
N
N
N
---
I
M
S
-
Y
W
F
E
E
P
--
Y
E
S
Y
R
E
L
E
D
L
H
I
K
H
---
I
----
H
D
Q
S
E
R
R
F
I
I
K
D
L
-
K
D
N
K
V
G
L
V
E
L
T
E
I
D
-
F
-
I
H
R
R
C
E
F
-
A
I
-
I
-
I
S
P
G
E
E
G
K
G
Y
A
T
E
A
T
D
L
T
V
E
Y
A
F
S
I
L
N
L
H
K
I
Y
L
L
V
D
E
D
N
P
A
A
L
H
I
Y
R
K
S
G
F
A
E
E
G
K
L
V
D
E
Y
Y
-
S
-
K
G
R
Y
R
T
A
I
R
M
Y
V
L
K
K
-----------------------------------------------------------------------------------------------------------------------------
65
HHSearch
64.21
20%
-80
- C1 -
1YRE
1
?
A:
[16-184]
---
T
L
Q
R
G
A
L
R
L
E
P
L
V
-
E
-
A
D
I
P
E
L
V
----
S
L
A
E
A
N
R
E
A
L
-
Q
Y
M
D
G
P
----
T
R
P
D
W
Y
R
Q
S
L
A
E
Q
--------
R
E
G
R
A
L
P
L
A
V
R
L
G
--
V
Q
L
V
G
T
T
R
F
A
E
F
L
-
P
-
A
L
P
A
C
E
I
-
G
W
T
W
-
L
D
Q
A
Q
H
G
S
G
L
N
R
M
I
K
Y
L
M
L
K
H
A
F
D
N
L
R
M
V
R
V
Q
L
S
T
A
A
S
N
L
R
A
Q
G
A
I
D
K
L
G
A
Q
R
E
G
V
L
R
N
H
R
R
L
A
-
G
G
R
L
D
D
T
F
V
Y
S
I
T
D
H
E
W
---------------------------------------------------------------------------------------------------------------------------
59
HHSearch
63.66
15%
-81
- C1 -
3OWC
5
ATSE2_PSEAE
A:
[13-180]
--------
E
L
Q
L
V
P
F
Q
-
L
-
G
H
F
P
I
L
Q
----
R
W
F
A
T
E
K
E
L
-
V
Q
W
A
G
P
A
L
R
H
P
L
S
L
E
Q
M
H
E
D
L
A
E
S
---
R
R
R
---
P
P
L
R
L
L
W
S
A
C
R
--
D
D
Q
V
I
G
H
C
Q
L
L
F
D
R
---
R
N
G
V
V
R
L
A
R
I
-
V
-
L
A
P
S
A
R
G
Q
G
L
G
L
P
M
L
E
A
L
L
A
E
A
F
A
D
A
D
I
E
R
V
E
L
N
V
Y
D
W
N
A
A
A
R
H
L
Y
R
R
A
G
F
R
E
E
G
L
R
R
S
A
T
R
-
V
-
G
R
E
R
W
N
V
V
L
M
G
L
L
R
Q
E
W
---------------------------------------------------------------------------------------------------------------------------
58
HHSearch
62.81
21%
-72
- C1 -
2Z10
-
?
A:
[7-176]
---
R
F
E
G
R
H
V
R
L
E
P
L
A
-
L
-
A
H
L
P
A
F
L
----
R
H
Y
-
D
-
P
E
V
-
Y
R
F
L
S
R
A
P
-
V
A
P
T
E
E
A
L
R
A
H
L
E
G
L
---
L
G
----
E
P
G
R
V
N
W
A
I
L
F
--
G
K
E
V
A
G
R
I
S
V
I
A
P
E
-
P
-
E
H
A
K
L
E
L
-
G
T
-
M
-
L
F
K
P
F
W
G
S
P
A
N
K
E
A
K
-
L
L
L
R
H
A
F
E
V
L
R
A
E
R
V
Q
F
K
V
D
L
R
N
E
R
S
Q
R
A
L
E
A
L
G
A
V
R
E
G
V
L
R
K
N
R
R
-
L
P
D
G
A
F
R
D
D
V
V
Y
S
V
L
K
E
E
W
---------------------------------------------------------------------------------------------------------------------------
75
Fugue
62.79
17%
-86
- C1 -
1YRE
2
?
A:
[13-195]
L
P
I
T
L
Q
R
G
A
L
R
L
E
P
L
V
-
E
-
A
D
I
P
E
L
V
----
S
L
A
E
A
N
R
E
A
L
---------
Q
Y
M
D
G
P
T
R
P
D
W
Y
R
Q
S
---
L
A
E
Q
-
R
E
G
--
R
A
L
P
L
A
V
R
L
G
V
Q
L
V
G
T
T
R
F
A
E
F
L
P
A
-
L
P
A
C
E
I
G
-
W
T
-
W
-
L
D
Q
A
Q
H
G
S
G
L
N
R
M
I
K
Y
L
M
L
K
H
A
F
D
N
L
R
M
V
R
V
Q
L
S
T
A
A
S
N
L
R
A
Q
G
A
I
D
K
L
G
A
Q
R
E
G
V
L
R
N
H
R
R
-
L
A
G
G
R
L
D
D
T
F
V
Y
S
I
T
D
H
E
W
P
Q
V
K
A
A
L
E
A
S
F----------------------------------------------------------------------------------------------------------------
68
HHSearch
61.86
19%
-84
- C1 -
2GE3
1
?
A:
[6-169]
-------
D
T
V
T
I
K
P
I
R
-
A
-
E
H
V
E
S
F
H
----
R
A
L
D
A
V
S
R
E
-
R
K
Y
L
S
F
L
E
--
A
P
P
L
E
A
V
R
A
F
V
L
D
M
---
I
E
----
N
-
D
H
P
Q
F
V
A
I
A
--
D
G
D
V
I
G
W
C
D
I
R
R
Q
D
R
A
T
R
A
H
C
G
T
L
-
G
M
-
G
-
I
L
P
A
Y
R
N
K
G
L
G
A
R
L
M
R
R
T
L
D
A
A
H
E
-
F
G
L
H
R
I
E
L
S
V
H
A
D
N
A
R
A
I
A
L
Y
E
K
I
G
F
A
H
E
G
R
A
R
D
A
V
S
-
I
-
D
G
H
Y
I
D
S
L
N
M
A
I
I
F
G
-----------------------------------------------------------------------------------------------------------------------------