@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1722: (2016-03-28 )
MTESNIPSFWAEKWQEHGYETPTEIQSAMYQPIKDGADVLAVSPTGTGKTVAYALPTLEKIEAIPKTQWLVLAPSHELVMQITEVIRSWLPSDDLTVISLIGGANVKRQIEKLKKKPQIIVASPGRALELIKQKKIKMHEIKTITLDECDQLLRQENFKSTLEIVESAVRDRQLTLVSATKLENPDMFFAQTENTPVMLEVTAKPEELTNVEHLYMDVESRDKATLLRRISHIKDMRGLVFVKDKPRMEILLEKLHYDKVKAAGIHGEIRKEKRKKYLDDFKKGTLTYLIVTDVAARGLDIEDLPYVIHYDLAASEKEYTHRSGRTGRMGKSGTVITFANPREIRTLKQYLTIHNLKGKQVRFYQGKLLDGAVPENKIAKKASRPPKQVQKSKKDDGKKPFRKDKPTGAAGGRKEKPTNSAKPTRNKPNKFNKKPNNFKKS
Atome Classification :
(35 SA)
.........10........20........30......-...40........50........60------.-.-.-------------------.----------..----------..--------70........80........90.-.......100.......110.-......120.......-130.......--140.......150...-....160.-------.....----.-170----........180-------.----........190.......200..-.....--210.......220.--.--.....230.-.--...-...240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTESN
I
P
S
F
W
A
E
K
W
Q
EHGYE
T
P
T
E
I
Q
S
A
M
Y
-
Q
P
IKDG-A
D
V
L
A
VSPTGTG
K
T
V
A
Y
ALP
T
L
E
K
I
------
E
-A-I-------------------P----------KT----------
Q
W
--------
L
V
LAP
S
H
E
L
V
M
Q
I
T
E
V
I
R
S
WLPS-DD
L
T
V
I
S
L
IGG
A
N
V
K
R
Q
I
E
K
L
-KKKP
Q
I
I
V
ASP
G
R
A
L
E
-
L
I
K
Q
KK
I
K
M
H
--
E
I
K
T
I
T
L
D
E
C
D
Q
L
L
R
Q
-
E
N
F
K
S
T
L
E
-------
I
V
E
S
A
----V-R-D----R
Q
L
T
L
V
S
A
T---------K----LENP
D
M
F
F
A
QTENT
P
V
M
L
E
V
TAK-
P
E
ELT--
N
V
E
H
L
Y
MDVESR
D
K
--
A
--
T
L
L
R
R
I
-
S
H
-
I
--
K
DM-R
G
L
V
F
VKDK
P
R
M
E
I
L
L
E
K
L
H
Y
D
KVKAAGI
H
G
E
I
R
K
E
K
R
K
K
Y
L
D
D
FKKG
T
L
T
Y
L
I
V
T
D
V
AARGLDIEDL
P
Y
V
I
H
YDLAASE
K
E
YTHRSGRTGRMGKSG
T
V
I
T
FA
N
P
R
E
I
R
T
L
K
Q
Y
L
T
I
HNLKG
K
Q
V
R
F
YQGKLLDGAVP
E
N
K
I
A
K
KASR
P
P
K
Q
V
Q
K
SKKDDGKKPFRKDKPTGAAGGRKEKPTNSAKPTRNKPNKFNKKPNNFKKS
77
HHSearch
91.95
31%
-85
- C7 -
2I4I
1
DDX3X_HUMAN
A:
[18-396]
-
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
-
P
I
I
K
E
K
-
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
------
Y
-
S
-
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
Q
----------
Y
P
----------
I
S
--------
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
-
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
-
G
F
E
P
Q
I
R
R
-------
I
V
E
Q
D
TMPP
K
-
G
-
V
----
R
H
T
M
M
F
S
A
T
---------
F
----
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-----
T
S
E
--
N
I
T
Q
K
V
V
W
V
E
E
S
D
K
--
R
--
S
F
L
L
D
L
-
L
N
-
A
TG
K
D
S
-
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
I
N
I
T
K
D
L
L
D
L
L
V
--------------------------------------------------------------------------------------
18
PsiBlast_PDB
87.99
31%
-93
- C7 -
2I4I
1
DDX3X_HUMAN
A:
[35-394]
------------------
Y
T
R
P
T
P
V
Q
K
H
A
I
-
P
I
I
K
E
K
-
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
DGPG
E
-
A
-
L
-------------------
R
A
M
K
E
NGRYGR
R
K
----------
Q
Y
P
I
S
-----
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
-
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
-
G
F
E
P
Q
I
R
R
-------
I
V
E
Q
D
----
T
-
M
-
P
PKGV
R
H
T
M
M
F
S
A
T
---------
F
----
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-----
T
S
E
--
N
I
T
Q
K
V
V
W
V
E
E
S
D
K
--
R
--
S
F
L
L
D
L
-
L
N
-
A
TG
K
D
S
-
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
I
N
I
T
K
D
L
L
D
L
----------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.76
32%
-92
- C7 -
4KBG
4
?
B:
[14-348]
-----------
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
-
P
L
A
L
E
G
-
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
APSQ--
E
-
R
-
G
-------------------
R
----------
K
P
----------
R
A
--------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
---
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
--
G
F
E
E
E
V
E
-------
A
L
L
S
A
----
T
P
P
-
S
----
R
Q
T
L
L
F
S
A
T
---------
L
----
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
---
D
E
P
V
--
T
Y
E
E
E
A
V
P
A
P
V
R
G
R
--
L
--
E
V
L
S
D
L
-
L
Y
-
V
--
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
R
R
------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
86.78
32%
-97
- C7 -
4KBF
1
?
B:
[14-348]
-----------
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
-
P
L
A
L
E
G
-
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
APSQ--
E
-
R
-
G
-------------------
R
----------
K
P
----------
R
A
--------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
---
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
--
G
F
E
E
E
V
E
-------
A
L
L
S
A
----
T
P
P
-
S
----
R
Q
T
L
L
F
S
A
T
---------
L
----
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
---
D
E
P
V
--
T
Y
E
E
E
A
V
P
A
P
V
R
G
R
--
L
--
E
V
L
S
D
L
-
L
Y
-
V
--
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
R
R
------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.16
32%
-87
- C7 -
4KBF
2
?
A:
[14-348]
-----------
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
-
P
L
A
L
E
G
-
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
APSQ--
E
-
R
-
G
-------------------
R
----------
K
P
----------
R
A
--------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
---
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
--
G
F
E
E
E
V
E
-------
A
L
L
S
A
----
T
P
P
-
S
----
R
Q
T
L
L
F
S
A
T
---------
L
----
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
---
D
E
P
V
--
T
Y
E
E
E
A
V
P
A
P
V
R
G
R
--
L
--
E
V
L
S
D
L
-
L
Y
-
V
--
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
R
R
------------------------------------------------------------------------------------------------
76
HHSearch
85.45
30%
-81
- C7 -
1HV8
5
H669_METJA
A:
[8-360]
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
-
P
L
F
L
N
D
E
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
L
V
------
N
-
E
-
N
-------------------
N
----------
G
I
----------
E
A
--------
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
G
N
-
K
N
L
K
I
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
-
A
-
L
K
N
A
N
I
V
V
G
T
P
G
R
I
L
D
-
H
I
N
R
G
T
L
N
L
K
--
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
N
M
-
G
F
I
K
D
V
E
K
-------
I
L
N
A
C
----
N
-
K
-
D
----
K
R
I
L
L
F
S
A
T
---------
M
----
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
K
A
K
-----
I
N
A
--
N
I
E
Q
S
Y
V
E
V
N
E
N
E
R
--
F
--
E
A
L
C
R
L
-
L
K
-
N
--
K
E
F
-
Y
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
E
Y
K
K
L
R
Y
I
E
R
A
M
K
L
K
------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.09
31%
-88
- C7 -
1HV8
5
H669_METJA
A:
[8-351]
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
D
E
-
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
L
V
------
N
-
E
-
N
-------------------
N
----------
G
I
----------
E
A
--------
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
G
N
-
K
N
L
K
I
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
A
L
-
K
N
-
A
N
I
V
V
G
T
P
G
R
I
L
D
-
H
I
N
R
G
T
L
N
L
K
--
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
N
M
-
G
F
I
K
D
V
E
K
-------
I
L
N
A
C
----
N
-
K
-
D
----
K
R
I
L
L
F
S
A
T
MP
R
E
I
L
N
L
A
K
----
K
Y
M
G
D
Y
S
F
-----------
I
K
A
K
-
I
N
--
A
--
N
I
E
Q
S
Y
V
E
V
N
E
N
E
R
--
F
--
E
A
L
C
R
L
-
L
K
-
N
--
K
E
F
-
Y
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
E
Y
K
K
L
R
---------------------------------------------------------------------------------------------
70
HHSearch
85.05
26%
-82
- C7 -
1S2M
-
DHH1_YEAST
A:
[48-410]
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
-
P
V
A
I
T
G
-
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
------
K
-
P
-
K
L------------------
N
----------
K
I
----------
Q
A
--------
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
-
C
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
-
L
A
S
R
K
V
A
D
L
S
--
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
-
D
F
K
T
I
I
E
Q
-------
I
L
S
F
L
----
P
-
P
-
T
----
H
Q
S
L
L
F
S
A
T
---------
F
----
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
M
E
E
--
L
T
L
K
--
G
I
T
Q
Y
Y
A
F
V
E
E
R
Q
K
--
L
--
H
C
L
N
T
L
-
F
S
-
K
L-
Q
I
N
-
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
A
I
P
-------------------------------------------------------------------------------
17
PsiBlast_PDB
84.91
31%
-75
- C7 -
4PXA
5
DDX3X_HUMAN
A:
[85-444]
------------------
Y
T
R
P
T
P
V
Q
K
H
A
I
-
P
I
I
K
E
K
-
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
DGPG
E
-
A
-
L
-------------------
R
A
M
K
E
NGRYGR
R
K
----------
Q
Y
P
I
S
-----
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
-
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
V
M
-
G
F
E
P
Q
I
R
R
-------
I
V
E
Q
D
----
T
-
M
-
P
PKGV
R
H
T
M
M
F
S
A
T
---------
F
----
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
-
G
S
T
S
E
--
N
I
T
Q
K
V
V
W
V
E
E
S
D
K
--
R
--
S
F
L
L
D
L
-
L
N
-
A
TG
K
D
S
-
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
N
I
N
I
T
K
D
L
L
D
L
----------------------------------------------------------------------------------------
16
PsiBlast_PDB
84.86
30%
-94
- C7 -
1S2M
-
DHH1_YEAST
A:
[63-388]
---------------
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
-
P
V
A
I
T
G
-
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
------
K
P
K
-
L
-------------------
N
----------
K
I
----------
Q
A
--------
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
-
C
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
-
L
A
S
R
K
V
A
D
L
S
--
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
-
D
-
F
K
T
I
I
E
-------
Q
I
L
S
F
----
L
-
P
P
T
----
H
Q
S
L
L
F
S
A
T
---------
F
----
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
M
----
E
E
L
T
LK
G
I
T
Q
Y
Y
A
F
V
E
E
R
Q
K
--
L
--
H
C
L
N
T
L
F
S
K
-
L
--
Q
I
N
-
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
-----------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
84.52
30%
-93
- C7 -
4BRU
-
DHH1_YEAST
A:
[18-343]
---------------
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
-
P
V
A
I
T
G
-
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
------
K
P
K
-
L
-------------------
N
----------
K
I
----------
Q
A
--------
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
-
C
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
-
L
A
S
R
K
V
A
D
L
S
--
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
-
D
-
F
K
T
I
I
E
-------
Q
I
L
S
F
----
L
-
P
P
T
----
H
Q
S
L
L
F
S
A
T
---------
F
----
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
M
----
E
E
L
T
LK
G
I
T
Q
Y
Y
A
F
V
E
E
R
Q
K
--
L
--
H
C
L
N
T
L
F
S
K
-
L
--
Q
I
N
-
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
-----------------------------------------------------------------------------------------------------
73
HHSearch
84.50
27%
-91
- C7 -
1XTI
4
DX39B_HUMAN
A:
[10-357]
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
-
P
Q
A
I
L
G
-
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
------
E
-
P
-
V
T------------------
G
----------
Q
V
----------
S
V
--------
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
P
N
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
K
K
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
-
L
A
R
N
K
S
L
N
L
K
--
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
D
M
R
R
D
V
Q
E
-------
I
F
R
M
T
----
P
-
H
-
E
----
K
Q
V
M
M
F
S
A
T
---------
L
----
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
E
T
K
L
T
L
H
--
G
L
Q
Q
Y
Y
V
K
L
K
D
N
E
K
--
N
--
R
K
L
F
D
L
-
L
D
V
L
--
E
F
N
-
Q
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
D
S
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
S
D
E
---------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
84.03
30%
-94
- C7 -
4BRW
2
DHH1_YEAST
A:
[18-343]
---------------
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
-
P
V
A
I
T
G
-
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
------
K
P
K
-
L
-------------------
N
----------
K
I
----------
Q
A
--------
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
-
C
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
-
L
A
S
R
K
V
A
D
L
S
--
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
-
D
-
F
K
T
I
I
E
-------
Q
I
L
S
F
----
L
-
P
P
T
----
H
Q
S
L
L
F
S
A
T
---------
F
----
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
M
----
E
E
L
T
LK
G
I
T
Q
Y
Y
A
F
V
E
E
R
Q
K
--
L
--
H
C
L
N
T
L
F
S
K
-
L
--
Q
I
N
-
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
-----------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.73
29%
-96
- C7 -
2J0S
3
IF4A3_HUMAN
A:
[55-389]
----------------
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
-
K
Q
I
I
K
G
-
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
------
D
-
I
Q
V
-------------------
R
----------
E
T
----------
Q
A
--------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
-
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
-
G
F
K
E
Q
I
Y
D
-------
V
Y
R
Y
L
----
P
-
P
-
A
----
T
Q
V
V
L
I
S
A
T
---------
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
----
P
I
R
I
L
V
K
R
D
-
E
L
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
--
K
F
D
T
L
C
D
L
Y
-
D
T
-
L
--
T
I
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
---------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.59
29%
-95
- C7 -
3EX7
4
IF4A3_HUMAN
C:
[56-390]
----------------
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
-
K
Q
I
I
K
G
-
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
------
D
-
I
Q
V
-------------------
R
----------
E
T
----------
Q
A
--------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
-
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
-
G
F
K
E
Q
I
Y
D
-------
V
Y
R
Y
L
----
P
-
P
-
A
----
T
Q
V
V
L
I
S
A
T
---------
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
----
P
I
R
I
L
V
K
R
D
-
E
L
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
--
K
F
D
T
L
C
D
L
Y
-
D
T
-
L
--
T
I
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
---------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.49
29%
-96
- C7 -
2HYI
3
IF4A3_HUMAN
C:
[56-390]
----------------
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
-
K
Q
I
I
K
G
-
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
------
D
-
I
Q
V
-------------------
R
----------
E
T
----------
Q
A
--------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
-
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
-
G
F
K
E
Q
I
Y
D
-------
V
Y
R
Y
L
----
P
-
P
-
A
----
T
Q
V
V
L
I
S
A
T
---------
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
----
P
I
R
I
L
V
K
R
D
-
E
L
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
--
K
F
D
T
L
C
D
L
Y
-
D
T
-
L
--
T
I
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
---------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.17
29%
-91
- C7 -
2J0Q
3
IF4A3_HUMAN
A:
[55-389]
----------------
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
-
K
Q
I
I
K
G
-
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
------
D
-
I
Q
V
-------------------
R
----------
E
T
----------
Q
A
--------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
-
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
-
G
F
K
E
Q
I
Y
D
-------
V
Y
R
Y
L
----
P
-
P
-
A
----
T
Q
V
V
L
I
S
A
T
---------
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
----
P
I
R
I
L
V
K
R
D
-
E
L
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
--
K
F
D
T
L
C
D
L
Y
-
D
T
-
L
--
T
I
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
---------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.10
29%
-93
- C7 -
2XB2
4
IF4A3_HUMAN
A:
[56-390]
----------------
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
-
K
Q
I
I
K
G
-
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
------
D
-
I
Q
V
-------------------
R
----------
E
T
----------
Q
A
--------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
-
M
N
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
R
S
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
-
G
F
K
E
Q
I
Y
D
-------
V
Y
R
Y
L
----
P
-
P
-
A
----
T
Q
V
V
L
I
S
A
T
---------
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
----
P
I
R
I
L
V
K
R
D
-
E
L
T
L
E
--
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
--
K
F
D
T
L
C
D
L
Y
-
D
T
-
L
--
T
I
T
-
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
R
I
L
R
---------------------------------------------------------------------------------------------
12
PsiBlast_PDB
82.64
29%
-77
- C7 -
4D26
4
?
A:
[55-404]
---
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
-
P
I
I
M
S
G
-
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
------
L
-
Q
-
D
-------------------
P
----------
K
D
L
I
S
E
NG
C
A
Q
P
Q
V
--------
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
-
S
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
N
R
V
S
F
G
--
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
--
G
F
M
P
S
I
E
K
M
M
L
HPT
M
V
E
T
T
--------
K
----
R
Q
T
L
M
F
S
A
T
---------
F
----
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
-
G
G
A
S
T
--
D
V
E
Q
I
F
I
E
V
T
K
Y
E
K
--
R
--
N
S
L
K
Q
L
-
I
E
-
E
--
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
-------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.43
29%
-78
- C7 -
4D25
4
?
A:
[55-404]
---
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
-
P
I
I
M
S
G
-
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
------
L
-
Q
-
D
-------------------
P
----------
K
D
L
I
S
E
NG
C
A
Q
P
Q
V
--------
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
-
S
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
N
R
V
S
F
G
--
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
--
G
F
M
P
S
I
E
K
M
M
L
HPT
M
V
E
T
T
--------
K
----
R
Q
T
L
M
F
S
A
T
---------
F
----
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
-
G
G
A
S
T
--
D
V
E
Q
I
F
I
E
V
T
K
Y
E
K
--
R
--
N
S
L
K
Q
L
-
I
E
-
E
--
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
-------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
80.78
30%
-96
- C7 -
2VSO
1
IF4A_YEAST
A:
[40-374]
----------------
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
-
M
P
I
I
E
G
-
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
------
D
T
S
-
V
-------------------
K
----------
A
P
----------
Q
A
--------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
-
M
D
I
K
V
H
A
C
I
G
----------
L
-
R
D
-
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
R
R
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
S
-
G
F
K
E
Q
I
Y
Q
-------
I
F
T
L
L
----
P
-
P
-
T
----
T
Q
V
V
L
L
S
A
T
---------
M
----
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
-
E
L
T
L
E
--
G
I
K
Q
F
Y
V
N
V
E
E
E
E
Y
K
Y
E
--
C
L
T
D
L
Y
-
D
S
-
I
--
S
V
T
-
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
--------------------------------------------------------------------------------------------
20
PsiBlast_PDB
80.67
30%
-93
- C7 -
2VSX
1
IF4A_YEAST
A:
[40-374]
----------------
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
-
M
P
I
I
E
G
-
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
------
D
T
S
-
V
-------------------
K
----------
A
P
----------
Q
A
--------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
-
M
D
I
K
V
H
A
C
I
G
----------
L
-
R
D
-
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
R
R
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
S
-
G
F
K
E
Q
I
Y
Q
-------
I
F
T
L
L
----
P
-
P
-
T
----
T
Q
V
V
L
L
S
A
T
---------
M
----
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
-
E
L
T
L
E
--
G
I
K
Q
F
Y
V
N
V
E
E
E
E
Y
K
Y
E
--
C
L
T
D
L
Y
-
D
S
-
I
--
S
V
T
-
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
V
G
A
M
R
E
--------------------------------------------------------------------------------------------
31
PsiBlast_CBE
63.02
35%
-97
- C7 -
2GXS
4
?
B:
[14-184]
-----------
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
-
P
L
A
L
E
G
-
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
APSQ--
E
-
R
-
G
-------------------
R
----------
K
P
----------
R
A
--------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
---
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
--
G
F
E
E
E
V
E
-------
A
L
L
S
A
----
T
P
P
-
S
----
R
Q
T
L
L
F
S
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
62.85
34%
-94
- C7 -
3NBF
2
?
A:
[14-184]
-----------
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
-
P
L
A
L
E
G
-
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
APSQ--
E
-
R
-
G
-------------------
R
----------
K
P
----------
R
A
--------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
---
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
--
G
F
E
E
E
V
E
-------
A
L
L
S
A
----
T
P
P
-
S
----
R
Q
T
L
L
F
S
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
62.81
35%
-96
- C7 -
2GXS
3
?
A:
[14-184]
-----------
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
-
P
L
A
L
E
G
-
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
APSQ--
E
-
R
-
G
-------------------
R
----------
K
P
----------
R
A
--------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
---
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
--
G
F
E
E
E
V
E
-------
A
L
L
S
A
----
T
P
P
-
S
----
R
Q
T
L
L
F
S
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
62.69
35%
-97
- C7 -
2GXQ
1
?
A:
[14-184]
-----------
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
-
P
L
A
L
E
G
-
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
APSQ--
E
-
R
-
G
-------------------
R
----------
K
P
----------
R
A
--------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
---
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
--
G
F
E
E
E
V
E
-------
A
L
L
S
A
----
T
P
P
-
S
----
R
Q
T
L
L
F
S
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
62.44
34%
-96
- C7 -
3NBF
2
?
B:
[14-184]
-----------
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
-
P
L
A
L
E
G
-
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
P
S
Q--
E
-
R
-
G
-------------------
R
----------
K
P
----------
R
A
--------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
---
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
--
G
F
E
E
E
V
E
-------
A
L
L
S
A
----
T
P
P
-
S
----
R
Q
T
L
L
F
S
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
62.15
34%
-98
- C7 -
3MWL
2
?
B:
[14-184]
-----------
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
-
P
L
A
L
E
G
-
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
APSQ--
E
-
R
-
G
-------------------
R
----------
K
P
----------
R
A
--------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
---
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
--
G
F
E
E
E
V
E
-------
A
L
L
S
A
----
T
P
P
-
S
----
R
Q
T
L
L
F
S
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
61.94
34%
-100
- C7 -
3NBF
3
?
C:
[14-184]
-----------
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
-
P
L
A
L
E
G
-
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
APSQ--
E
-
R
-
G
-------------------
R
----------
K
P
----------
R
A
--------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
---
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
--
G
F
E
E
E
V
E
-------
A
L
L
S
A
----
T
P
P
-
S
----
R
Q
T
L
L
F
S
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
61.45
34%
-95
- C7 -
3MWK
2
?
B:
[14-184]
-----------
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
-
P
L
A
L
E
G
-
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
APSQ--
E
-
R
-
G
-------------------
R
----------
K
P
----------
R
A
--------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
---
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
G
V
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
M
--
G
F
E
E
E
V
E
-------
A
L
L
S
A
----
T
P
P
-
S
----
R
Q
T
L
L
F
S
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
61.04
32%
-105
- C7 -
2PL3
5
DDX10_HUMAN
A:
[41-212]
--------------
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
-
G
L
A
L
Q
G
-
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
---------
E
-
A
-
L
-------------------
Y
----------
R
L
----------
Q
W
TSTDGLG
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
K
N
-
H
D
F
S
A
G
L
I
I
G
G
--
L
K
H
E
A
E
R
I
--
N
N
I
N
I
L
V
C
T
P
G
R
L
L
Q
-
H
M
D
E
-
T
V
S
F
H
AT
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
D
M
--
G
F
A
D
T
M
N
A
------
V
I
E
N
L
----
P
-
K
-
K
----
R
Q
T
L
L
F
S
A
T
---------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
58.12
32%
-73
- C7 -
3BER
4
DDX47_HUMAN
A:
[49-226]
----
G
V
T
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
-
P
L
A
L
Q
G
-
R
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
N
A
L
------
L
-
E
-
T
-------------------
P
----------
Q
R
----------
L
F
A
-------
L
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
F
E
A
L
G
S
S
-
I
G
V
Q
S
A
V
I
V
G
G
I
D
S
M
S
Q
S
L
A
L
-
A
K
K
P
H
I
I
I
A
T
P
G
R
L
I
D
H
L
E
N
T
K
G
F
N
L
R
--
A
L
K
Y
L
V
M
D
E
A
D
R
I
L
N
M
-
D
F
E
T
E
V
D
K
-------
I
L
K
V
I
----
P
-
R
-
D
----
R
K
T
F
L
F
S
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
53.45
33%
-97
- C7 -
4PX9
1
DDX3X_HUMAN
A:
[85-238]
------------------
Y
T
R
P
T
P
V
Q
K
H
A
I
-
P
I
I
K
E
K
-
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
GPG
E
-
A
-
L
-------------------
R
AMKENGRYG
R
R
K
----------
Q
Y
P
I
S
-----
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
-
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
52.97
33%
-96
- C7 -
4PX9
1
DDX3X_HUMAN
C:
[85-238]
------------------
Y
T
R
P
T
P
V
Q
K
H
A
I
-
P
I
I
K
E
K
-
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
YSDGPG
E
-
A
-
L
-------------------
R
AMKENGRYGR
R
K
----------
Q
Y
PIS-----
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
-
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
52.96
33%
-97
- C7 -
4PX9
1
DDX3X_HUMAN
B:
[85-238]
------------------
Y
T
R
P
T
P
V
Q
K
H
A
I
-
P
I
I
K
E
K
-
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
GPG
E
-
A
-
L
-------------------
R
AMKENGRYG
R
R
K
----------
Q
Y
P
I
S
-----
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
-
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
G
K
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------